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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Principles and practices of antimicrobial stewardship programs in Korea | This review addresses the escalating challenge posed by antibiotic resistance, highlighting its profound impact on global public health, including increased mortality rates and healthcare expenditures. The review focuses on the need to adopt the One Health approach to effectively manage antibiotic usage across human, animal, and environmental domains. Antimicrobial stewardship programs (ASPs) are considered as comprehensive strategies that encompass both core and supplementary initiatives aimed at enhancing prudent antibiotic use. The 2021 "Guidelines on Implementing ASP in Korea" introduced such strategies, with a strong emphasis on fostering multidisciplinary and collaborative efforts. Furthermore, the "Core Elements for Implementing ASPs in Korean General Hospitals," established in 2022, provide a structured framework for ASPs, delineating leadership responsibilities, the composition of interdisciplinary ASP teams, a range of interventions, and continuous monitoring and reporting mechanisms. In addition, this review examines patient-centric campaigns such as "Speak Up, Get Smart" and emphasizes the pivotal role of a multidisciplinary approach and international cooperation in addressing the multifaceted challenges associated with antibiotic resistance. | Kwon, Ki Tae; Kim, Shin-Woo | Kyungpook Natl Univ, Sch Med, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea | Kim, Hanjin/KYP-2633-2024; Kim, Ik-Sang/J-5425-2012 | 9733850500; 8710731500 | ksw2kms@knu.ac.kr; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 39 | 3 | SCIE | MEDICINE, GENERAL & INTERNAL | 2024 | 2.4 | 23.3 | 0 | 2025-05-07 | 0 | 1 | Antimicrobial stewardship; Microbial drug resistance; Core elements of ASP; Strategies of ASPs; One health | INFECTIOUS-DISEASES SOCIETY; HEALTH-CARE EPIDEMIOLOGY; ANTIBIOTIC USE; GUIDELINES; RESISTANCE; AMERICA | Antimicrobial stewardship; Core elements of ASP; Microbial drug resistance; One health; Strategies of ASPs | Animals; Anti-Bacterial Agents; Antimicrobial Stewardship; Drug Resistance, Bacterial; Humans; One Health; Practice Patterns, Physicians'; Republic of Korea; antibiotic agent; antiinfective agent; antibiotic resistance; antimicrobial stewardship; bacterial infection; clinical practice; collaborative care team; drug use; general hospital; global health; health care cost; health care planning; health program; human; international cooperation; Korea; Korean (people); leadership; monitoring; mortality rate; nonhuman; One Health; practice guideline; public health; public health campaign; Review; unnecessary prescribing; animal; antibiotic resistance; clinical practice; One Health; organization and management; South Korea | English | 2024 | 2024-05 | 10.3904/kjim.2023.482 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Quality of Life of Young Gastric Cancer Survivors: An Interpretation in the Context of Our Society | Background and Objectives: This retrospective case-control study aimed to investigate the quality of life (QoL) of young gastric cancer survivors and determine what should be pursued to obtain the best QoL for them after surgery. Materials and Methods: Patients with stage I gastric cancer who underwent distal subtotal gastrectomy were included. The European Organization for Research and Treatment of Cancer Quality of Life questionnaires were used to assess QoL. The QoL outcomes of younger (age 30-49 years, n = 76) and older (age 50-69 years, n = 232) groups were compared preoperatively, 3 months, and 1 year postoperatively. Results: There was no statistically significant difference in the preoperative QoL except for the physical functioning scale, which favored the younger group (p = 0.020). This difference remained significant throughout the postoperative periods (3 months, p = 0.002; 1 year, p = 0.004). Better QoL was found for the younger group according to the body image scale (p = 0.031). However, it was limited to the 3-month postoperative assessment. Persistent QoL disadvantages for the younger group were revealed by the diarrhea scale at the 3-month (p = 0.007) and 1-year (p = 0.005) postoperative assessments. Conclusions: While young gastric cancer survivors enjoyed better QoL in physical functioning and body image, worse QoL was related to diarrhea after surgery. Despite ever-rising concerns about QoL deterioration in elderly patients in our aged society, young gastric cancer survivors also need QoL support. | Lee, Seung Soo | Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu 41566, South Korea; Kyungpook Natl Univ Hosp, Dept Surg, Daegu 41566, South Korea | 54400392100 | peterleess@knu.ac.kr; | MEDICINA-LITHUANIA | MEDICINA-LITHUANIA | 1010-660X | 1648-9144 | 60 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2024 | 2.4 | 23.3 | 0 | 2025-04-16 | 0 | 0 | competitive behavior; diarrhea; gastrectomy; quality of life; stomach neoplasm | TOTAL GASTRECTOMY; ELDERLY-PATIENTS; CONSTIPATION; INSTRUMENT; CARCINOMA; STOMACH; QLQ-C30 | competitive behavior; diarrhea; gastrectomy; quality of life; stomach neoplasm | Adult; Aged; Cancer Survivors; Case-Control Studies; Diarrhea; Gastrectomy; Humans; Middle Aged; Quality of Life; Retrospective Studies; Stomach Neoplasms; Surveys and Questionnaires; adult; aged; cancer survivor; case control study; diarrhea; gastrectomy; human; middle aged; procedures; quality of life; questionnaire; retrospective study; stomach tumor | English | 2024 | 2024-01 | 10.3390/medicina60010009 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Reduced risk of gastrointestinal bleeding associated with eupatilin in aspirin plus acid suppressant users: nationwide population-based study | Background/Aims: Mucoprotective agents, such as eupatilin, are often prescribed to prevent gastrointestinal (GI) bleeding in addition to an acid suppressant despite the absence of a large-scale study. We evaluated the additional effect of eupatilin on the prevention of GI bleeding in both the upper and lower GI tract in concomitant aspirin and acid suppressant users using the nationwide database of national claims data from the Korean National Health Insurance Service (NHIS). Methods: An aspirin cohort was constructed using the NHIS claims data from 2013 to 2020. Patients who manifested with hematemesis, melena, or hematochezia were considered to have GI bleeding. A Cox proportional hazards regression model was used to determine the risk factors for GI bleeding associated with the concomitant use of GI drugs and other covariates among aspirin users. Results: Overall, a total of 432,208 aspirin users were included. The concurrent use of an acid suppressant and eupatilin (hazard ratio [HR] = 0.85, p = 0.016, vs. acid suppressant only) was a statistically significant preventive factor for GI bleeding. Moreover, a more than 3-month duration (HR = 0.88, p = 0.030) of acid suppressant and eupatilin prescription (vs. acid suppressant only) was a statistically significant preventive factor for GI bleeding. Conclusions: Eupatilin administration for >= 3 months showed additional preventive effect on GI bleeding in concomitant aspirin and acid suppressant users. Thus, cotreatment with eupatilin with a duration of 3 months or longer is recommended for reducing GI bleeding among aspirin plus acid suppressant users. | Lee, Hyun Seok; Nam, Ji Hyung; Oh, Dong Jun; Moon, Yeo Rae; Lim, Yun Jeong | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Dongguk Univ, Coll Med, Dept Internal Med, Ilsan Hosp, Goyang, South Korea; KakaoHealthcare Corp, Data Platform Div, Seongnam, South Korea; Dongguk Univ, Ilsan Hosp, Coll Med, Div Gastroenterol,Dept Internal Med, 27 Dongguk Ro, Goyang 10326, South Korea | LIM, Yun Jeong/KVY-6446-2024 | 36647886100; 42361607200; 57203029221; 58918183700; 56501161800 | drlimyj@gmail.com; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 39 | 2 | SCIE | MEDICINE, GENERAL & INTERNAL | 2024 | 2.4 | 23.3 | 0.49 | 2025-05-07 | 3 | 2 | Aspirin; Artemisia; Anti-ulcer agents; Gastrointestinal hemorrhage | LOW-DOSE ASPIRIN; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; DOUBLE-BLIND; PREVENTION; DA-9601; ULCER; MISOPROSTOL; INFECTION; DISEASE; DAMAGE | Anti-ulcer agents; Artemisia; Aspirin; Gastrointestinal hemorrhage | Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Flavonoids; Gastrointestinal Agents; Gastrointestinal Hemorrhage; Humans; Risk Factors; acetylsalicylic acid; eupatilin; flavonoid; unclassified drug; acetylsalicylic acid; eupatilin; flavonoid; gastrointestinal agent; nonsteroid antiinflammatory agent; aged; Article; cohort analysis; disease association; female; gastrointestinal hemorrhage; hematemesis; hematochezia; human; major clinical study; male; melena; prescription; risk factor; risk reduction; treatment duration; gastrointestinal hemorrhage | English | 2024 | 2024-03 | 10.3904/kjim.2023.324 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Self-screening questionnaire for perianal fistulizing disease in patients with Crohn's disease | Background/Aims: A poor prognostic factor for Crohn's disease (CD) includes perianal fistulizing disease, including perianal fistula and/or perianal abscess. Currently, a tool to assess perianal symptoms in patients with CD remains nonexistent. This study aimed to develop a perianal fistulizing disease self-screening questionnaire for patients with CD. Methods: This prospective pilot study was conducted at three tertiary referral centers between January 2019 and May 2020. We formulated questions on perianal symptoms, including tenesmus, anal discharge, bleeding, pain, and heat. A 4-point Likert scale was used to rate each question. Patients with CD completed a questionnaire and underwent pelvic magnetic resonance imaging (MRI). Results: Overall, 93 patients were enrolled, with 51 (54.8%) diagnosed with perianal fistulizing disease, as determined by pelvic MRI. The Spearman correlation findings demonstrated that anal pain (p = 0.450, p < 0.001) and anal discharge (p = 0.556, p < 0.001) were the symptoms that most significantly correlated with perianal disease. For anal pain and discharge, the area under the receiver operating characteristic curve of the scores was significantly higher than that of the combined score for all five symptoms (0.855 vs. 0.794, DeLong's test p = 0.04). For the two symptoms combined, the sensitivity, specificity, and positive predictive and negative predictive values were 88.2, 73.8, 80.4, and 83.8%, respectively, with 81.7% accuracy for detecting perianal fistulizing disease. Conclusions: This study indicates that simple questions regarding anal pain and discharge can help accurately identify the presence of perianal fistulizing disease in patients with CD. | Kweon, O. Seong; Kang, Ben; Lee, Yoo Jin; Kim, Eun Soo; Kim, Sung Kook; Lee, Hyun Seok; Chung, Yun Jin; Kim, Kyeong Ok; Jang, Byung Ik | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Gastroenterol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Keimyung Univ, Dept Internal Med, Div Gastroenterol, Sch Med, Daegu, South Korea; Yeungnam Univ, Coll Med, Dept Internal Med, Div Gastroenterol, Daegu, South Korea | 康, 奔/JMQ-0812-2023; Lee, Yoojin/AAB-9799-2022; Kwak, Sang Gyu/AAG-4341-2021; Kim, Sang/J-5398-2012 | 58553046300; 57194823199; 55531365900; 57203086704; 34770060400; 36647886100; 57199411938; 53363798100; 22953491400 | dandy813@hanmail.net; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 39 | 3 | SCIE | MEDICINE, GENERAL & INTERNAL | 2024 | 2.4 | 23.3 | 0 | 2025-05-07 | 0 | 0 | Perianal fistulizing Crohn's disease; Perianal disease; Screening tool | INFLAMMATORY-BOWEL-DISEASE; INFLIXIMAB; CONSENSUS; THERAPY; TRIAL; INDEX; ECCO | Perianal disease; Perianal fistulizing Crohn’s disease; Screening tool | Adult; Crohn Disease; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Pilot Projects; Predictive Value of Tests; Prospective Studies; Rectal Fistula; Reproducibility of Results; Surveys and Questionnaires; Young Adult; C reactive protein; adult; anal pain; anus disease; anus fistula; Article; bleeding; controlled study; Crohn disease; disease activity; disease course; disease duration; female; Harvey Bradshaw Index; human; human cell; leukocyte count; Likert scale; major clinical study; male; nuclear magnetic resonance imaging; pain; pilot study; predictive value; prospective study; self evaluation; sensitivity and specificity; tenesmus; tertiary care center; clinical trial; complication; diagnostic imaging; middle aged; multicenter study; nuclear magnetic resonance imaging; predictive value; questionnaire; rectum fistula; reproducibility; young adult | English | 2024 | 2024-05 | 10.3904/kjim.2023.410 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The combined use of anti-peptic agents is associated with an increased risk of osteoporotic fracture: a nationwide case-control study | Background/Aims: Long-term use of acid suppressants such as proton pump inhibitors (PPIs) and histamine 2 receptor antagonist (H2RA) has been associated with the risk of osteoporotic fracture. Acid suppressants and muco-protective agents (MPAs) are often used together as anti -ulcer agents. We evaluated the association between the risk of osteoporotic fracture and the combined use of these anti -peptic agents. Methods: A population -based case -control study was conducted by analyzing the Korean National Health Insurance Data from 2014 to 2020. Patients who had been prescribed anti -peptic agents, such as PPI, H2RA, or MPA, were included. Considering the incidence of osteoporotic fractures, the case group (n = 14,704) and control group (n = 58,816) were classified by 1:4 matching based on age and sex. Results: The use of all types of anti -peptic agents was associated with an increased risk of osteoporotic fractures (PPI: hazard ratio [HR], 1.31; H2RA: HR, 1.44; and MPA: HR, 1.33; all p < 0.001). Compared to PPI alone, the combined use of "PPI and H2RA" (HR, 1.58; p = 0.010) as well as "PPI, H2RA, and MPA" (HR, 1.71; p = 0.001) was associated with an increased risk of osteoporotic fracture. However, compared with PPI alone, "MPA and PPI or H2RA" was not associated with an increased risk of osteoporotic fracture. Conclusions: This study found that the combined use of "PPI and H2RA" was associated with a higher risk of osteoporotic fractures. In cases where deemed necessary, the physicians may initially consider prescribing the combination use of MPA. | Oh, Dong Jun; Nam, Ji Hyung; Lee, Hyun Seok; Moon, Yeo Rae; Lim, Yun Jeong | Dongguk Univ, Ilsan Hosp, Dept Internal Med, 27 Dongguk Ro, Goyang 10326, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; KakaoHealthcare Corp, Data Platform Div, Seongnam, South Korea | LIM, Yun Jeong/KVY-6446-2024 | 57203029221; 42361607200; 36647886100; 58918183700; 56501161800 | drlimyj@gmail.com; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 39 | 2 | SCIE | MEDICINE, GENERAL & INTERNAL | 2024 | 2.4 | 23.3 | 0.49 | 2025-05-07 | 1 | 1 | Anti-ulcer agents; Proton pump inhibitor; Histamine H2 antagonists; Osteoporotic fracture | EPIDEMIOLOGY; PREVENTION; DIAGNOSIS | Anti-ulcer agents; Histamine H2 antagonists; Osteoporotic fracture; Proton pump inhibitor | Anti-Ulcer Agents; Case-Control Studies; Histamine H2 Antagonists; Humans; Osteoporotic Fractures; Proton Pump Inhibitors; alginic acid; antiulcer agent; cimetidine; dexlansoprazole; ecabet; esomeprazole; eupatilin; famotidine; histamine H2 receptor antagonist; ilaprazole; irsogladine maleate; lafutidine; lansoprazole; misoprostol; muco protective agent; nizatidine; omeprazole; pantoprazole; proton pump inhibitor; rabeprazole; ranitidine; rebamipide; roxatidine; teprenone; troxipide; unclassified drug; antiulcer agent; histamine H2 receptor antagonist; proton pump inhibitor; adult; age distribution; aged; Article; case control study; cohort analysis; controlled study; drug safety; female; fragility fracture; high risk patient; human; incidence; major clinical study; male; middle aged; national health insurance; prescription; risk factor; sex ratio; South Korea; very elderly; fragility fracture | English | 2024 | 2024-03 | 10.3904/kjim.2023.326 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Tight junction protein changes in irritable bowel syndrome: the relation of age and disease severity | Background/Aims: The etiology of irritable bowel syndrome (IBS) is associated with intestinal mucosal barrier damage. However, changes in the tight junction (TJ) proteins in IBS have not been fully elucidated. This study aimed to evaluate TJ protein changes in IBS patients and the relationship between aging and disease severity. Methods: Thirty-six patients with IBS fulfilling the Rome IV criteria and twenty-four controls were included. To evaluate the change of TJ in the colonic mucosa, quantitative reverse transcription polymerase chain reaction, western blot, and immunohistochemistry (IHC) were performed, respectively. Results: The entire IBS group (n = 36) exhibited decreased levels of claudin-1 and-2 mRNA compared to the control group (n = 24), with statistical significance (p < 0.05). Additionally, in western blot analyses, both claudin-1 and ZO-1 levels were significantly reduced in the IBS group compared to the control group (n = 24) (p < 0.05). IHC analysis further revealed that ZO-1 expression was significantly lower in the IBS group than in the control group (p < 0.001). This trend of reduced ZO-1 expression was also observed in the moderate-to-severe IBS subgroup (p < 0.001). Significantly, ZO-1 expression was notably lower in both the young- (p = 0.036) and old-aged (p = 0.039) IBS groups compared to their respective age-matched control groups. Subtype analysis indicated a more pronounced decrease in ZO-1 expression with advancing age. Conclusions: ZO-1 expression was especially decreased in the aged IBS group. These results suggest that ZO-1 might be the prominent TJ protein causing IBS in the aging population. | Kim, Sang Un; Choi, Ji A.; Han, Man-Hoon; Choi, Jin Young; Park, Ji Hye; Kim, Moon Sik; Kwon, Yong Hwan | Kyungpook Natl Univ Hosp, Dept Internal Med, 807 Hoguk Ro, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea | 57061064900; 59412269200; 57194067936; 57210752356; 57250156800; 57195918515; 55775556800 | tear9754006@yahoo.co.kr; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 39 | 6 | SCIE | MEDICINE, GENERAL & INTERNAL | 2024 | 2.4 | 23.3 | 0 | 2025-05-07 | 0 | 0 | Irritable bowel syndrome; Tight junction; Aging; Colon | BARRIER FUNCTION; EXPRESSION; DIARRHEA; PERMEABILITY; DYSFUNCTION; DISORDERS; CLAUDIN-2; SYMPTOMS; OCCLUDIN; IBS | Aging; Colon; Irritable bowel syndrome; Tight junction | Adult; Age Factors; Aged; Case-Control Studies; Claudin-1; Claudin-2; Claudins; Colon; Female; Humans; Immunohistochemistry; Intestinal Mucosa; Irritable Bowel Syndrome; Male; Middle Aged; RNA, Messenger; Severity of Illness Index; Tight Junctions; Young Adult; Zonula Occludens-1 Protein; claudin 1; claudin 2; messenger RNA; protein ZO1; tight junction protein; claudin; claudin 1; claudin 2; CLDN1 protein, human; CLDN2 protein, human; messenger RNA; protein ZO1; TJP1 protein, human; adult; age distribution; aged; aging; Article; clinical article; colon mucosa; controlled study; disease severity; female; human; human tissue; immunohistochemistry; irritable colon; male; pathophysiology; protein expression; real time reverse transcription polymerase chain reaction; risk factor; Western blotting; age; case control study; colon; genetics; intestine mucosa; irritable colon; metabolism; middle aged; pathology; severity of illness index; tight junction; young adult | English | 2024 | 2024-11 | 10.3904/kjim.2024.097 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Understanding of Depressive Symptomatology across Major Depressive Disorder and Bipolar Disorder: A Network Analysis | Background and Objectives: Depressive symptoms are prominent in both major depressive disorder (MDD) and bipolar disorder (BD). However, comparative research on the network structure of depressive symptoms in these two diagnostic groups has been limited. This study aims to compare the network structure of depressive symptoms in MDD and BD, providing a deeper understanding of the depressive symptomatology of each disorder. Materials and Methods: The Zung Self-Rating Depressive Scale, a 20-item questionnaire, was administered to assess the depressive symptoms in individuals with MDD (n = 322) and BD (n = 516). A network analysis was conducted using exploratory graph analysis (EGA), and the network structure was analyzed using regularized partial correlation models. To validate the dimensionality of the Zung SDS, principal component analysis (PCA) was adopted. Centrality measures of the depressive symptoms within each group were assessed, followed by a network comparison test between the two groups. Results: In both diagnostic groups, the network analysis revealed four distinct categories, aligning closely with the PCA results. "Depressed affect" emerged as the most central symptom in both MDD and BD. Furthermore, non-core symptoms, "Personal devaluation" in MDD and "Confusion" in BD, displayed strong centrality. The network comparison test did not reveal significant differences in the network structure between MDD and BD. Conclusions: The absence of significant differences in the network structures between MDD and BD suggests that the underlying mechanisms of depressive symptoms may be similar across these disorders. The identified central symptoms, including "Depressed affect", in both disorders and the distinct non-core symptoms in each highlight the complexity of the depressive symptomatology. Future research should focus on validating these symptoms as therapeutic targets and incorporate various methodologies, including non-metric dimension reduction techniques or canonical analysis. | Lee, Hyukjun; Jang, Junwoo; Kang, Hyo Shin; Lee, Jakyung; Lee, Daseul; Yu, Hyeona; Ha, Tae Hyon; Park, Jungkyu; Myung, Woojae | Seoul Natl Univ, Bundang Hosp, Dept Neuropsychiat, Seongnam 13620, South Korea; Kyungpook Natl Univ, Dept Psychol, Daegu 41566, South Korea; Seoul Natl Univ, Dept Psychiat, Coll Med, Seoul 03080, South Korea | ; Ha, Tae/U-5558-2019; Myung, Woojae/AAD-3016-2021 | 58749939700; 58846141500; 57219595147; 57972918600; 57973764300; 57910913300; 7203014550; 56206565000; 37099034100 | lhj4071@gmail.com;julian6312@gmail.com;hyoshin.kang@knu.ac.kr;jklee96@ewhain.net;dasulee627@gmail.com;hkhkh9274@gmail.com;hatti@snu.ac.kr;jkp@knu.ac.kr;wmyung@snu.ac.kr; | MEDICINA-LITHUANIA | MEDICINA-LITHUANIA | 1010-660X | 1648-9144 | 60 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2024 | 2.4 | 23.3 | 0.94 | 2025-04-16 | 2 | 2 | bipolar disorder; data analysis; depression; major depressive disorder; mood disorders | BORDERLINE PERSONALITY-DISORDER; SYMPTOMS; UNIPOLAR; COMORBIDITY; PSYCHOPATHOLOGY; ASSOCIATION; IMPAIRMENT; PREVALENCE; RECURRENCE; MORTALITY | bipolar disorder; data analysis; depression; major depressive disorder; mood disorders | Bipolar Disorder; Confusion; Depressive Disorder, Major; Humans; Principal Component Analysis; bipolar disorder; complication; confusion; human; major depression; principal component analysis | English | 2024 | 2024-01 | 10.3390/medicina60010032 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Urolithiasis in Kidney Transplant Patients: A Multicenter KSER Research Series | Background and Objectives: Urolithiasis occurrence is uncommon in kidney transplantation patients, though it has serious implications, including acute kidney injury in the transplanted kidney. This study investigates the leading causes of urolithiasis in kidney transplantation patients, the diagnostic process, and the outcomes of multimodal management. Materials and Methods: Data collection spanned from January 1997 to December 2021, involving kidney transplantation patients with urolithiasis from the database of the Korean Society of Endourology and Robotics (KSER) research committee. Analysis encompassed factors triggering urolithiasis, the diagnostic process, stone attributes, treatment methods, and outcomes. Results: Our analysis included 58 kidney transplantation patients with urolithiasis from eight medical centers. Of these patients, 37 were male and 4 had previous urolithiasis diagnoses. The mean age was 59.09 +/- 10.70 years, with a mean duration from kidney transplantation to diagnosis of 76.26 +/- 183.14 months. The most frequent method of stone detection was through asymptomatic routine check-ups (54.7%). Among the 58 patients, 51 underwent stone treatment. Notably, 95.3% of patients with ureter stones received treatment, a significantly higher rate than the 66.7% of patients with renal stones (p = 0.010). Success rates showed no significant differences between renal (70%) and ureter stone (78.0%) groups (p = 0.881). Conclusions: Urolithiasis in transplanted kidneys constitutes an acute condition requiring emergency intervention. Endo-urological interventions are effective for kidney transplantation patients with urolithiasis. To ensure prevention and early detection, diligent follow-up and routine imaging tests are necessary. | Shim, Kang Hee; Choi, Kwi Bok; Kim, Woong Bin; Yang, Seung Woo; Kim, Do Kyung; Choo, Min Soo; Chung, Doo Yong; Jung, Hae Do; Lee, Sin Woo; Kim, Bum Soo; Jeon, Seung Hyun; Kang, Seok Ho; Paick, Sunghyun; Lee, Joo Yong | Ajou Univ, Sch Med, Dept Urol, Suwon 16499, South Korea; Natl Police Hosp, Dept Urol, Seoul 05715, South Korea; Soonchunhyang Univ, Bucheon Hosp, Dept Urol, Bucheon 14584, South Korea; Chungnam Natl Univ, Coll Med, Dept Urol, Daejeon 35015, South Korea; U Well Urol Clin, Dept Urol, Daejeon 35233, South Korea; Soonchunhyang Univ, Coll Med, Soonchunhyang Univ Hosp, Dept Urol, Seoul 04401, South Korea; Seoul Natl Univ, Seoul Metropolitan Govt, Boramae Med Ctr, Dept Urol, Seoul 07061, South Korea; Inha Univ, Coll Med, Dept Urol, Incheon 22212, South Korea; Inje Univ, Ilsan Paik Hosp, Coll Med, Dept Urol, Goyang 10380, South Korea; Seoul Med Ctr, Dept Urol, Seoul 02053, South Korea; Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu 41944, South Korea; Kyung Hee Univ, Sch Med, Dept Urol, Seoul 02447, South Korea; Korea Univ, Coll Med, Dept Urol, Seoul 02841, South Korea; Konkuk Univ, Sch Med, Dept Urol, Seoul 05030, South Korea; Yonsei Univ, Coll Med, Severance Hosp, Urol Sci Inst,Dept Urol, Seoul 03722, South Korea; Yonsei Univ, Inst Convergence Sci, Ctr Evidence Based Med, Seoul 03722, South Korea | Jeon, Seung Hyun/AFN-3212-2022; Kim, Soo-Yeon/ADR-9663-2022; Lee, Joo Yong/ADE-2110-2022 | 56369937900; 58846563100; 54389391800; 36166130500; 57201678355; 37074378700; 57210889520; 56387960800; 55898016000; 57202817150; 7203005251; 7405684686; 6507407846; 55205621500 | jenius85@hanmail.net;acala0905@gmail.com;woongbins@schmc.ac.kr;white0941@hanmail.net;dokyung@schmc.ac.kr;mschoo@snu.ac.kr;dychung@inha.ac.kr;haedojung@paik.ac.kr;icinoo0923@naver.com;urokbs@knu.ac.kr;juro@khu.ac.kr;mdksh@korea.ac.kr;drsilent@kuh.ac.kr;joouro@yuhs.ac; | MEDICINA-LITHUANIA | MEDICINA-LITHUANIA | 1010-660X | 1648-9144 | 60 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2024 | 2.4 | 23.3 | 0.94 | 2025-04-16 | 1 | 1 | acute renal injury; renal transplantation; urolithiasis | STONE COMPOSITION; MANAGEMENT; LITHIASIS; LASERS; FLUID | acute renal injury; renal transplantation; urolithiasis | Aged; Asian People; Female; Humans; Kidney; Kidney Calculi; Kidney Transplantation; Male; Middle Aged; Urolithiasis; aged; Asian; clinical trial; female; human; kidney; kidney transplantation; male; middle aged; multicenter study; nephrolithiasis; urolithiasis | English | 2024 | 2024-01 | 10.3390/medicina60010132 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | A lipase from Lacticaseibacillus rhamnosus IDCC 3201 with thermostability and pH resistance for use as a detergent additive | Lipases are important biocatalysts and ubiquitous in plants, animals, and microorganisms. The high growth rates of microorganisms with low production costs have enabled the wide application of microbial lipases in detergent, food, and cosmetic industries. Herein, a novel lipase from Lacticaseibacillus rhamnosus IDCC 3201 (Lac-Rh) was isolated and its activity analyzed under a range of reaction conditions to evaluate its potential industrial application. The isolated Lac-Rh showed a molecular weight of 24 kDa and a maximum activity of 3438.5 +/- 1.8 U/mg protein at 60 degrees C and pH 8. Additionally, Lac-Rh retained activity in alkaline conditions and in 10% v/v concentrations of organic solvents, including glycerol and acetone. Interestingly, after pre-incubation in the presence of multiple commercial detergents, Lac-Rh maintained over 80% of its activity and the stains from cotton were successfully removed under a simulated laundry setting. Overall, the purified lipase from L. rhamnosus IDCC 3201 has potential for use as a detergent in industrial applications. | Kang, Mi Dan; Choi, Go Eun; Jang, Jeong Hwa; Hong, Sung-Chul; Park, Hee-Soo; Kim, Dong Hyun; Kim, Won Chan; Murphy, Natasha P.; Jung, Young Hoon | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kunsan Natl Univ, Dept Food Sci & Biotechnol, Gunsan 54150, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Dept Integrat Biol, Daegu 41566, South Korea; Natl Renewable Energy Lab, Renewable Resources & Enabling Sci Ctr, Golden, CO 80401 USA | Kim, Dong Hyun/LDT-2672-2024; Jung, Young Hoon/F-1703-2013; Park, Hee-Soo/AAC-6422-2019; Jung, Young/F-1703-2013; KIM, WON/AAJ-4506-2020; Hong, Sung-Chul/ABA-5643-2021 | 57311023600; 59162107400; 57208244041; 58612005000; 15751448400; 55574224522; 55492085000; 58961519100; 55550063700 | Natasha.murphy@nrel.gov;younghoonjung@knu.ac.kr; | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | APPL MICROBIOL BIOT | 0175-7598 | 1432-0614 | 108 | 1 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 4.3 | 23.4 | 0.46 | 2025-05-07 | 1 | 1 | Lipase; Recombinant enzyme; Detergent additive; Thermostability; pH resistance | LICHENIFORMIS NCU CS-5; BACILLUS-LICHENIFORMIS; ORGANIC-SOLVENT; ALKALINE LIPASE; BIOCHEMICAL-CHARACTERIZATION; LIPOLYTIC ENZYMES; TOLERANT LIPASE; PURIFICATION; ESTERASE; CLASSIFICATION | Detergent additive; Lipase; pH resistance; Recombinant enzyme; Thermostability | Bacterial Proteins; Detergents; Enzyme Stability; Hydrogen-Ion Concentration; Lacticaseibacillus rhamnosus; Lipase; Molecular Weight; Temperature; Acetone; Additives; Alkalinity; Cleaning; Lipases; Purification; Soaps (detergents); Stability; acetone; agar; detergent; dimethyl sulfoxide; glycerol; metal ion; methanol; organic solvent; recombinant enzyme; solvent; triacylglycerol lipase; bacterial protein; triacylglycerol lipase; Cosmetic industry; Detergent additive; Detergent industry; Food industries; High growth-rate; Microbial lipase; pH resistance; Production cost; Reaction conditions; Recombinant enzymes; additive; bacterium; cotton; detergent; enzyme activity; pH; protein; alkalinity; amino acid sequence; Article; bacterial strain; bacterium isolate; concentration (parameter); controlled study; enzymatic hydrolysis; enzyme activity; enzyme purification; enzyme specificity; enzyme stability; Escherichia coli; Lactobacillus rhamnosus; molecular weight; nonhuman; pH; protein secondary structure; temperature; thermostability; chemistry; enzyme stability; enzymology; genetics; metabolism; pH; Microorganisms | English | 2024 | 2024-12 | 10.1007/s00253-024-13185-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Cultured fecal microbial community and its impact as fecal microbiota transplantation treatment in mice gut inflammation | The fecal microbiome is identical to the gut microbial communities and provides an easy access to the gut microbiome. Therefore, fecal microbial transplantation (FMT) strategies have been used to alter dysbiotic gut microbiomes with healthy fecal microbiota, successfully alleviating various metabolic disorders, such as obesity, type 2 diabetes, and inflammatory bowel disease (IBD). However, the success of FMT treatment is donor-dependent and variations in gut microbes cannot be avoided. This problem may be overcome by using a cultured fecal microbiome. In this study, a human fecal microbiome was cultured using five different media; growth in brain heart infusion (BHI) media resulted in the highest microbial community cell count. The microbiome (16S rRNA) data demonstrated that the cultured microbial communities were similar to that of the original fecal sample. Therefore, the BHI-cultured fecal microbiome was selected for cultured FMT (cFMT). Furthermore, a dextran sodium sulfate (DSS)-induced mice-IBD model was used to confirm the impact of cFMT. Results showed that cFMT effectively alleviated IBD-associated symptoms, including improved gut permeability, restoration of the inflamed gut epithelium, decreased expression of pro-inflammatory cytokines (IFN-gamma, TNF-alpha, IL-1, IL-6, IL-12, and IL-17), and increased expression of anti-inflammatory cytokines (IL-4 and IL-10). Thus, study's findings suggest that cFMT can be a potential alternative to nFMT.Key points center dot In vitro fecal microbial communities were grown in a batch culture using five different media.center dot Fecal microbial transplantation was performed on DSS-treated mice using cultured and normal fecal microbes.center dot Cultured fecal microbes effectively alleviated IBD-associated symptoms.Key points center dot In vitro fecal microbial communities were grown in a batch culture using five different media.center dot Fecal microbial transplantation was performed on DSS-treated mice using cultured and normal fecal microbes.center dot Cultured fecal microbes effectively alleviated IBD-associated symptoms.Key points center dot In vitro fecal microbial communities were grown in a batch culture using five different media.center dot Fecal microbial transplantation was performed on DSS-treated mice using cultured and normal fecal microbes.center dot Cultured fecal microbes effectively alleviated IBD-associated symptoms. | Singh, Vineet; Choi, Seung-Dae; Mahra, Kanika; Son, Hyunwoo; Lee, Hoyul; Lee, Yu-Jeong; Kim, Eun Soo; Shin, Jae-Ho | Kyungpook Natl Univ, Dept Appl Biosci, Daegu, South Korea; Microbalance Co Ltd, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Aging & Metab, Daegu, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea | Singh, Vineet/ABC-7000-2021; Son, Hyunwoo/ABC-5701-2020 | 57211642447; 57215651369; 58998079500; 57218872919; 58017533900; 57189520824; 57203086704; 57224125922 | jhshin@knu.ac.kr; | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | APPL MICROBIOL BIOT | 0175-7598 | 1432-0614 | 108 | 1 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 4.3 | 23.4 | 0.46 | 2025-05-07 | 2 | 2 | Fecal microbiome; Cultured fecal microbes; Fecal microbial transplantation; Gut inflammation; Microbial therapeutics | PROINFLAMMATORY CYTOKINES; BOWEL-DISEASE; COLITIS | Cultured fecal microbes; Fecal microbial transplantation; Fecal microbiome; Gut inflammation; Microbial therapeutics | Animals; Bacteria; Culture Media; Cytokines; Dextran Sulfate; Disease Models, Animal; Fecal Microbiota Transplantation; Feces; Gastrointestinal Microbiome; Humans; Inflammatory Bowel Diseases; Male; Mice; Mice, Inbred C57BL; RNA, Ribosomal, 16S; dextran sulfate; gamma interferon; gamma1b interferon; genomic DNA; interleukin 1; interleukin 10; interleukin 12; interleukin 17; interleukin 4; interleukin 6; messenger RNA; RNA 16S; tumor necrosis factor; cytokine; RNA 16S; Cultured fecal microbe; Fecal microbial transplantation; Fecal microbiome; Gut inflammation; Inflammatory bowel disease; Microbial communities; Microbial therapeutic; Microbials; Microbiome; brain; disease prevalence; fecal coliform; microbial community; RNA; rodent; transplantation; animal cell; animal experiment; animal model; animal tissue; Article; bacterial microbiome; bacterium culture; brain; brain heart infusion; controlled study; fecal microbiota transplantation; feces analysis; feces microflora; heart; human; inflammatory bowel disease; infusion; microbial community; mouse; nonhuman; small intestine epithelium; animal; bacterium; C57BL mouse; chemistry; classification; culture medium; disease model; feces; genetics; inflammatory bowel disease; intestine flora; isolation and purification; male; metabolism; microbiology; procedures; therapy; Macroinvertebrates | English | 2024 | 2024-12 | 10.1007/s00253-024-13295-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Inhibition of Granule Cell Dispersion and Seizure Development by Astrocyte Elevated Gene-1 in a Mouse Model of Temporal Lobe Epilepsy | Although granule cell dispersion (GCD) in the hippocampus is known to be an important feature associated with epileptic seizures in temporal lobe epilepsy (TLE), the endogenous molecules that regulate GCD are largely unknown. In the present study, we have examined whether there is any change in AEG-1 expression in the hippocampus of a kainic acid (KA)-induced mouse model of TLE. In addition, we have investigated whether the modulation of astrocyte elevated gene-1 (AEG-1) expression in the dentate gyrus (DG) by intracranial injection of adeno-associated virus 1 (AAV1) influences pathological phenotypes such as GCD formation and seizure susceptibility in a KA-treated mouse. We have identified that the protein expression of AEG-1 is upregulated in the DG of a KA-induced mouse model of TLE. We further demonstrated that AEG-1 upregulation by AAV1 delivery in the DG-induced anticonvulsant activities such as the delay of seizure onset and inhibition of spontaneous recurrent seizures (SRS) through GCD suppression in the mouse model of TLE, while the inhibition of AEG-1 expression increased susceptibility to seizures. The present observations suggest that AEG-1 is a potent regulator of GCD formation and seizure development associated with TLE, and the significant induction of AEG-1 in the DG may have therapeutic potential against epilepsy. | Leem, Eunju; Kim, Sehwan; Sharma, Chanchal; Nam, Youngpyo; Kim, Tae Yeon; Shin, Minsang; Lee, Seok-Geun; Kim, Jaekwang; Kim, Sang Ryong | Kyungpook Natl Univ, Sch Life Sci, FOUR KNU Creat Biores Grp BK21, Daegu 41566, South Korea; Korea Brain Res Inst, Dementia Res Grp, Daegu 41062, South Korea; Daegu Gyeongbuk Med Innovat Fdn K MEDI Hub, New Drug Dev Ctr, Efficacy Evaluat Dept, Daegu 41061, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Microbiol, Daegu 41944, South Korea; Kyung Hee Univ, Dept Biomed Sci & Technol, Seoul 02447, South Korea; Kyung Hee Univ, BioNanocomposite Res Ctr, Seoul 02447, South Korea | ; Lee, Seok-Geun/B-3408-2011 | 56019011900; 57193232250; 57193577728; 55143100300; 57218127454; 7401536650; 57368561500; 57201935123; 56486163800 | leem@kmedihub.re.kr;arputa@knu.ac.kr;chanchalmrt@gmail.com;blackpyo2@knu.ac.kr;taetaey@hanmail.net;shinms@knu.ac.kr;seokgeun@khu.ac.kr;kim_jaekwang@kbri.re.kr;srk75@knu.ac.kr; | BIOMOLECULES | BIOMOLECULES | 2218-273X | 14 | 3 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2024 | 4.8 | 23.4 | 0.39 | 2025-05-07 | 1 | 1 | adeno-associated virus 1; adeno-associated viral vector; astrocyte elevated gene-1; gene therapy; granule cell dispersion; hippocampus; kainic acid; mammalian target of rapamycin complex 1; seizure; temporal lobe epilepsy | RAPID SUBTRACTION HYBRIDIZATION; SIGNALING PATHWAY; MAMMALIAN TARGET; DENTATE GYRUS; NEURONS; REELIN; TRANSDUCTION; EXPRESSION; RAPAMYCIN; CLONING | adeno-associated viral vector; adeno-associated virus 1; astrocyte elevated gene-1; gene therapy; granule cell dispersion; hippocampus; kainic acid; mammalian target of rapamycin complex 1; seizure; temporal lobe epilepsy | Animals; Astrocytes; Dentate Gyrus; Epilepsy; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Mice; Seizures; anticonvulsive agent; beta actin; glial fibrillary acidic protein; hemagglutinin; hydroxymethylglutaryl coenzyme A reductase kinase kinase; initiation factor 4E binding protein 1; kainic acid; ketamine; mammalian target of rapamycin complex 1; pilocarpine; protein p70; sequestosome 1; xylazine; kainic acid; Adeno associated virus 1; animal cell; animal experiment; animal model; animal tissue; Article; cell granule; confocal microscopy; controlled study; dentate gyrus; dispersion; fluorescence microscopy; forelimb; gene expression; gene overexpression; gene silencing; hippocampus; immunofluorescence assay; immunohistochemistry; intracranial drug administration; light chain; male; MAPK signaling; mouse; nerve cell inhibition; Nissl staining; nonhuman; pathology; phenotype; Pi3K/Akt signaling; protein expression; seizure; seizure susceptibility; temporal lobe epilepsy; therapeutic index; tonic clonic seizure; type 1 astrocyte; upregulation; Western blotting; animal; astrocyte; epilepsy; genetics; metabolism; seizure; temporal lobe epilepsy | English | 2024 | 2024-03 | 10.3390/biom14030380 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Interaction Between Nitric Oxide and Silicon on Leghaemoglobin and S-Nitrosothiol Levels in Soybean Nodules | Nitrogen fixation in legume nodules is crucial for plant growth and development. Therefore, this study aims to investigate the effects of nitric oxide [S-nitrosoglutathione (GSNO)] and silicon [sodium metasilicate (Si)], both individually and in combination, on soybean growth, nodule formation, leghaemoglobin (Lb) synthesis, and potential post-translational modifications. At the V1 stage, soybean plants were treated for 2 weeks with 150 mu M GSNO, and Si at concentrations of 1 mM, 2 mM, and 4 mM. The results showed that NO and Si enhance the nodulation process by increasing phenylalanine ammonia-lyase activity and Nod factors (NIP2-1), attracting rhizobia and accelerating nodule formation. This leads to a greater number and larger diameter of nodules. Individually, NO and Si support the synthesis of Lb and leghaemoglobin protein (Lba) expression, ferric leghaemoglobin reductases (FLbRs), and S-nitrosoglutathione reductase (GSNOR). However, when used in combination, NO and Si inhibit these processes, leading to elevated levels of S-nitrosothiols in the roots and nodules. This combined inhibition may potentially induce post-translational modifications in FLbRs, pivotal for the reduction of Lb3+ to Lb2+. These findings underscore the critical role of NO and Si in the nodulation process and provide insight into their combined effects on this essential plant function. | Lee, Da-Sol; Das, Ashim Kumar; Methela, Nusrat Jahan; Yun, Byung-Wook | Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Appl Biosci, Daegu 41566, South Korea | ; Das, Ashim Kumar/ABB-6751-2020 | 57222624235; 57211473983; 57880065700; 8245123600 | giftanna@naver.com;ashim@knu.ac.kr;methela.ag@nstu.edu.bd;bwyun@knu.ac.kr; | BIOMOLECULES | BIOMOLECULES | 2218-273X | 14 | 11 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2024 | 4.8 | 23.4 | 0 | 2025-05-07 | 0 | 0 | ferric leghaemoglobin reductases; leghaemoglobin; nitric oxide; nodule formation; silicon; soybean plants | FERRIC LEGHEMOGLOBIN; NITROGEN-FIXATION; LEGUME; ROOT; GENE; PERCEPTION; NITRATE; BIOSYNTHESIS; HEMOGLOBIN; EXPRESSION | ferric leghaemoglobin reductases; leghaemoglobin; nitric oxide; nodule formation; silicon; soybean plants | Glycine max; Leghemoglobin; Nitric Oxide; Plant Proteins; Root Nodules, Plant; S-Nitrosoglutathione; S-Nitrosothiols; Silicon; ferric leghaemoglobin reductase; leghemoglobin; nitric oxide; oxidoreductase; phenylalanine ammonia lyase; s nitrosoglutathione; s nitrosoglutathione reductase 1; s nitrosothiol; silicon; unclassified drug; plant protein; s nitrosoglutathione; silicon; Article; chlorophyll content; concentration (parameter); down regulation; enzyme activity; gene expression; gene expression profiling; hemoglobin synthesis; molecular interaction; nitrogen fixation; nodulation; nonhuman; plant growth; protein expression; protein processing; real time polymerase chain reaction; Rhizobiaceae; root length; S-nitrosylation; shoot length; soybean; upregulation; drug effect; metabolism | English | 2024 | 2024-11 | 10.3390/biom14111417 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Is Hemopexin a Nephrotoxin or a Marker of Kidney Injury in Renal Ischemia-Reperfusion? | Destabilization of heme proteins is recognized to play a role in acute kidney injury (AKI). Hemopexin (Hpx), known for its role in binding heme, mitigates free heme toxicity. Despite this, the potential adverse effects of Hpx deposition in kidney tissues and its impact on kidney function are not fully understood. Deferoxamine (DFO) chelates iron released from heme and mitigates associated kidney damage. Therefore, this study aimed to evaluate whether Hpx contributes to kidney injury in an ischemia-reperfusion injury (IRI) induced AKI model and to investigate if DFO could alleviate this damage. Mice were categorized into five groups: Sham-Vehicle, Sham-Hpx, IRI-Vehicle, IRI-Hpx, and IRI-Hpx-DFO. Decline in kidney function was observed exclusively in the IRI group, independent of Hpx injection. Serum Hpx levels remained comparable across all groups, and administration of Hpx did not alter serum Hpx levels or kidney function after 24 hours. Although increased Hpx deposition in kidneys was noted in both the IRI and Hpx groups, this accumulation did not correlate with impaired kidney function. Additionally, DFO did not exhibit a protective effect against kidney injury. In summary, Hpx does not directly induce kidney injury and cannot be considered a biomarker for kidney damage caused by IRI. | Jeon, You Hyun; Oh, Eun-Joo; Oh, Se-Hyun; Lim, Jeong-Hoon; Jung, Hee-Yeon; Choi, Ji-Young; Cho, Jang-Hee; Park, Sun-Hee; Kim, Yong-Lim; Kim, Chan-Duck | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Div Nephrol,Dept Internal Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu 41944, South Korea | Kim, Yong-Lim/AGK-3172-2022; Cho, Jang-hee/ABD-3534-2020; Park, Sun-Hee/LMN-0033-2024; Jung, Hee-Yeon/AFB-8578-2022; Lim, Jeong-Hoon/ABE-6003-2020 | 57820096000; 35783223700; 56053033900; 55360244300; 57196396467; 7501393222; 7403536291; 7501831741; 55633533600; 8558530700 | bon2bon@naver.com;oej1124@naver.com;sehyun.oh@knu.ac.kr;jh-lim@knu.ac.kr;hy-jung@knu.ac.kr;jyss1002@hanmail.net;jh-cho@knu.ac.kr;sh-park@knu.ac.kr;ylkim@knu.ac.kr;drcdkim@knu.ac.kr; | BIOMOLECULES | BIOMOLECULES | 2218-273X | 14 | 12 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2024 | 4.8 | 23.4 | 0 | 2025-05-07 | 0 | 0 | acute kidney injury; biomarker; hemopexin; ischemia-reperfusion injury | HEME OXYGENASE; INDUCTION; DISEASE; PROTEIN; RHABDOMYOLYSIS; TOXICITY; THERAPY; IRON | acute kidney injury; biomarker; hemopexin; ischemia-reperfusion injury | Acute Kidney Injury; Animals; Biomarkers; Deferoxamine; Disease Models, Animal; Hemopexin; Kidney; Male; Mice; Mice, Inbred C57BL; Reperfusion Injury; deferoxamine; hemopexin; isoflurane; Nephrotoxin; toxin; unclassified drug; biological marker; deferoxamine; acute kidney failure; animal experiment; animal tissue; apoptosis; Article; cell viability assay; controlled study; disease severity; enzyme linked immunosorbent assay; glomerulus filtration rate; kidney function; kidney injury; kidney tissue; male; microaneurysm; mouse; nonhuman; oxidative stress; protein expression; renal ischemia reperfusion injury; Western blotting; animal; blood; C57BL mouse; disease model; drug effect; drug therapy; kidney; metabolism; reperfusion injury | English | 2024 | 2024-12 | 10.3390/biom14121522 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Recent developments in the synthesis of tetraethylenepentamine-based nanocomposites to eliminate heavy metal pollutants from wastewater through adsorption | This article talks about how to make and use nanocomposites with a tetraethylenepentamine (TEPA-NCs) core for adsorption purposes to get heavy metals (HMs) out of polluted water. The present review critically discusses the synthesis methods, structural characteristics, and functional properties of newly developed TEPA-NCs, together with mechanisms associated with the adsorption of different types of HMs. The high adsorption capacity for various metal ions is due to the presence of functional groups on the surface of TEPA-NCs. The adsorbents show great potential for reuse since they can be reused for several consecutive cycles while maintaining high removal. Isothermal studies confirm that adsorption is favored at pH close to neutrality. The interactions are mostly physical in nature. The isothermal studies mostly corresponded to the Langmuir model, while the kinetic studies corresponded to the pseudo-second-order model. As future recommendations, it is important to analyze the costs of manufacturing these materials. | El Messaoudi, Noureddine; Miyah, Youssef; Georgin, Jordana; Wasilewska, Malgorzata; Felisardo, Raul Jose Alves; Moukadiri, Houda; Manzar, Mohammad Saood; Aryee, Aaron Albert; Knani, Salah; Rahman, Md. Mahmudur | Ibn Zohr Univ, Fac Sci, Lab Appl Chem & Environm, Agadir 80000, Morocco; Univ Sidi Mohamed Ben Abdellah, Higher Sch Technol, Lab Mat Proc Catalysis & Environm, Fes, Morocco; Minist Hlth & Social Protect, Higher Inst Nursing Profess & Hlth Tech, Fes, Morocco; Univ Costa, Dept Civil & Environm, CUC, Calle 58 55-66, Barranquilla, Atlantico, Colombia; Maria Curie Sklodowska Univ Lublin, Fac Chem, Inst Chem Sci, Dept Phys Chem, Maria Curie Sklodowska Sq 3, PL-20031 Lublin, Poland; Univ Tiradentes, Grad Program Proc Engn, 300 Murilo Dantas Ave, BR-49032490 Aracaju, SE, Brazil; Arizona State Univ, Sch Sustainable Engn & Built Environm, Tempe, AZ 85287 USA; Mohammed VI Polytech Univ UM6P, High Inst Biol & Paramed Sci, Fac Med Sci FMS, ISSB P, Benguerir, Morocco; Imam Abdulrahman Bin Faisal Univ, Coll Engn, Dept Environm Engn, Dammam, Saudi Arabia; Kyungpook Natl Univ, Coll Engn, Environm Remediat Engn Lab, Daegu, South Korea; Northern Border Univ, Coll Sci, Dept Phys, Ar Ar, Saudi Arabia; Bangladesh Council Sci & Ind Res BCSIR, Dhaka, Bangladesh | Georgin, Jordana/X-8378-2019; Knani, Salah/KLZ-9572-2024; georgin, jordana/X-8378-2019; Rahman, Mahmudur/AAY-6502-2021; Felisardo, Raul/AAD-3374-2021; Miyah, Youssef/GPC-5225-2022; manzar, saood/T-7480-2018 | 56465946700; 56418488400; 56974226900; 57103781000; 57219696872; 58671073700; 57192993469; 57208484034; 37059284800; 57468792200 | noureddine.elmessaoudi@edu.uiz.ac.ma;youssef.miyah@gmail.com; | BIORESOURCE TECHNOLOGY REPORTS | BIORESOUR TECH REP | 2589-014X | 28 | ESCI | ENERGY & FUELS;ENVIRONMENTAL SCIENCES;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 4.3 | 23.4 | 2.87 | 2025-05-07 | 23 | 28 | Adsorption; Regeneration and reusability; Environmental impacts; Electrostatic interactions; Kinetic and isothermal studies; TEPA-based nanocomposites | ACTIVATED CARBON; AQUEOUS-SOLUTION; GRAPHENE OXIDE; TERNARY NANOCOMPOSITE; CHEMICAL-MODIFICATION; FACILE PREPARATION; ION REMOVAL; CHITOSAN; ADSORBENT; COMPOSITE | Adsorption; Electrostatic interactions; Environmental impacts; Kinetic and isothermal studies; Regeneration and reusability; TEPA-based nanocomposites | Cleaner production; Heavy metals; Nanoclay; Reusability; Characteristic properties; Heavy metal pollutants; Kinetic and isothermal study; Polluted water; Regeneration and reusability; Structural characteristics; Structural-functional; Synthesis method; TEPA-based nanocomposite; Tetraethylenepentamine | English | 2024 | 2024-12 | 10.1016/j.biteb.2024.101982 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effect of demethylation of acetone-soluble softwood kraft lignin on adhesion of lignin-phenol-formaldehyde resins | Owing to the increasing interest in sustainability and bio-based materials, softwood kraft lignin (SKL) was acetone-fractionated to reduce its heterogeneity and then demethylated to substitute phenol in lignin-phenol-formaldehyde (LPF) resins to be used as bio-based wood adhesives. This study investigated the effect of the demethylation of acetone-soluble SKL (AS-SKL) on the adhesion of LPF resins, where phenol was partially replaced with acetone-soluble demethylated kraft lignin (AS-DKL). Characterization of SKL, AS-KL, and AS-DKL using gel permeation chromatography (GPC), FTIR, and 31P NMR spectroscopy showed that the demethylation was successfully performed; the molecular weight (MW) and the number of methoxy groups decreased, and the number of -OH groups increased. The MW, chemical reactions, and curing behavior of LPF resins synthesized with different AS-DKL levels (10, 20, 30, and 50 wt%) were also characterized. With the increase in AS-DKL content, the viscosity and MW of the resin increased, whereas the gelation time decreased. LPF resins with 10% AS-DKL showed the highest tensile shear strength and lowest peak curing temperature. These results suggest that 10% is an optimal AS-DKL level in LPF resins for plywood bonding and that demethylation is an effective way of utilizing SKL. | Kim, Minjeong; Park, Byung-Dae | Kyungpook Natl Univ, Dept Wood & Paper Sci, Daegu, South Korea | Park, Byung-Dae/ABB-1934-2020 | 57215818497; 7402834820 | byungdae@knu.ac.kr; | JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY | J ADHES SCI TECHNOL | 0169-4243 | 1568-5616 | 38 | 10 | SCIE | ENGINEERING, CHEMICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;MECHANICS | 2024 | 3.7 | 23.7 | 0 | 2025-04-16 | 1 | 1 | Softwood kraft lignin; acetone fractionation; demethylation; lignin-phenol-formaldehyde resins; adhesion | REPLACEMENT | acetone fractionation; adhesion; demethylation; lignin–phenol–formaldehyde resins; Softwood kraft lignin | Acetone; Adhesives; Chemical Bonds; Curing; Formaldehyde; Gel Permeation Chromatography; Acetone; Adhesives; Chemical bonds; Curing; Formaldehyde; Fourier transform infrared spectroscopy; Gel permeation chromatography; Gelation; Lignin; Nuclear magnetic resonance spectroscopy; Phenols; Acetone fractionation; Bio-based; Bio-based materials; Demethylation; FTIR; Gel-permeation chromatography; Kraft lignin; Lignin phenol formaldehyde resin; Softwood kraft lignins; Wood adhesives; Adhesion | English | 2024 | 2024-05-18 | 10.1080/01694243.2023.2273618 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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