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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | Meeting Abstract | Extensive mosaicism by somatic L1 retrotransposition in normal human cells | Ju, Young Seok; Nam, Changhyun; Youk, Jeongwhan; Kim, Jeongyeon; Lim, Joonoh; Park, Jungwoo; Oh, Sooa; Lee, Hyunjung; Park, Jiwon; Jeong, Seungyong; Lee, Dongsung; Oh, Jiwon; Han, Jinju; Lee, Junehawk; Kwon, Hyunwoo; Kim, Minjung | Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Daejeon, South Korea; Genome Insight Inc, San Diego, CA USA; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Korea Inst Sci & Technol Informat KISTI, Daejeon, South Korea; Seoul Natl Univ, Dept Surg, Coll Med, Seoul, South Korea; Univ Seoul, Dept Life Sci, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Anat, Daegu, South Korea; Yonsei Univ, Dept Anat, Coll Med, Seoul, South Korea; Korea Univ, Dept Nucl Med, Coll Med, Seoul, South Korea | Ju, Young/E-1324-2012; Han, Jinju/D-9091-2017 | CANCER SCIENCE | CANCER SCI | 1347-9032 | 1349-7006 | 114 | SCIE | ONCOLOGY | 2023 | 4.5 | 24.1 | 0 | English | 2023 | 2023-02 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Article | Favorable Effect of High-Density Lipoprotein Cholesterol on Gastric Cancer Mortality by Sex and Treatment Modality | Studies on the effects of high-density lipoprotein cholesterol (HDL-C) on gastric cancer mortality are few, and the results are inconsistent. In this study, we investigated the effects of HDL-C on gastric cancer mortality and conducted sub-group analysis by sex and treatment modality. Newly diagnosed patients with gastric cancer (n = 22,468) who underwent gastric cancer screening between January 2011 and December 2013 were included and followed up until 2018. A validation cohort (n = 3379) that had newly diagnosed gastric cancer from 2005 to 2013 at a university hospital, was followed up until 2017. HDL-C was inversely related with mortality; adjusted hazard ratio (aHR) 0.90 (95% confidence interval [CI], 0.83-0.98) for HDL-C of 40-49 mg/dL, 0.86 (0.79-0.93) for HDL-C of 50-59 mg/dL, 0.82 (0.74-0.90) for HDL-C of 60-69 mg/dL, and 0.78 (0.69-0.87) for HDL-C = 70 mg/dL compared to HDL-C < 40 mg/dL. In the validation cohort, HDL-C was also inversely associated with mortality; aHR 0.81 (0.65-0.99) for HDL-C of 40-49 mg/dL, 0.64 (0.50-0.82) for HDL-C of 50-59 mg/dL, and 0.46 (0.34-0.62) for HDL-C = 60 mg/dL compared to HDL-C < 40 mg/dL. The two cohorts demonstrated that higher HDL-C was associated with a low risk of mortality in both sexes. In validation cohort, this association was observed in both gastrectomy and endoscopic resection (p for trend < 0.001) as more remarkable in endoscopic resection group. In this study, we explored that an increased HDL-C reduced mortality in both sexes and curative resection group. | Nam, Su Youn; Jeon, Seong Woo; Jo, Junwoo; Kwon, Oh Kyoung | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Surg, Daegu 41944, South Korea | ; Jeon, Seongwoo/AAU-4618-2020 | 55617028500; 9733636500; 57210425017; 26536109900 | swjeon@knu.ac.kr; | CANCERS | CANCERS | 2072-6694 | 15 | 9 | SCIE | ONCOLOGY | 2023 | 4.5 | 24.1 | 0.45 | 2025-06-25 | 3 | 3 | gastric cancer; mortality; high-density lipoprotein cholesterol; sex; treatment modality | BODY-MASS INDEX; SURVIVAL; PROGRAM; COHORT; RISK | gastric cancer; high-density lipoprotein cholesterol; mortality; sex; treatment modality | high density lipoprotein cholesterol; adult; aged; Article; body mass; cancer mortality; cancer screening; cerebrovascular disease; cohort analysis; diabetes mellitus; dyslipidemia; endometrium cancer; endoscopic submucosal dissection; endoscopic surgery; endoscopy; female; follow up; gastrectomy; glucose blood level; human; hyperlipidemia; hypertension; hysterectomy; major clinical study; male; mortality risk; overall survival; questionnaire; sensitivity analysis; stomach cancer | English | 2023 | 2023-04-25 | 10.3390/cancers15092463 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Histone modification in Saccharomyces cerevisiae: A review of the current status | The budding yeast Saccharomyces cerevisiae is a well-characterized and popular model system for in-vestigating histone modifications and the inheritance of chromatin states. The data obtained from this model organism have provided essential and critical information for understanding the complexity of epigenetic interactions and regulation in eukaryotes. Recent advances in biotechnology have facilitated the detection and quantitation of protein post-translational modification (PTM), including acetylation, me-thylation, phosphorylation, ubiquitylation, sumoylation, and acylation, and led to the identification of several novel modification sites in histones. Determining the cellular function of these new histone markers is essential for understanding epigenetic mechanisms and their impact on various biological processes. In this review, we describe recent advances and current views on histone modifications and their effects on chromatin dynamics in S. cerevisiae.(c) 2023 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY license (http://creative-commons.org/licenses/by/4.0/). | Chou, Kwon Young; Lee, Jun-Yeong; Kim, Kee-Beom; Kim, Eunjeong; Lee, Hyun-Shik; Ryu, Hong-Yeoul | Kyungpook Natl Univ, Coll Natl Sci, Sch Life Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Natl Sci, Sch Life Sci, BK21 Plus KNU Creat Biores Grp, Daegu 41566, South Korea | Kim, Kee-Beom/AFL-8804-2022 | 58136893700; 56428518900; 58136893800; 56892981600; 16316010200; 55889917800 | rhr4757@knu.ac.kr; | COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL | COMPUT STRUCT BIOTEC | 2001-0370 | 21 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2023 | 4.5 | 24.1 | 1.55 | 2025-06-25 | 13 | 12 | Histone acetylation; Histone methylation; Histone phosphorylation; Histone ubiquitylation; Histone sumoylation; Histone acylation | CHROMATIN-REMODELING COMPLEX; H3 VARIANT CSE4; H2B UBIQUITYLATION; DEACETYLASE COMPLEX; GENE-EXPRESSION; TRANSCRIPTIONAL ACTIVATION; LYSINE SUCCINYLATION; ARGININE METHYLATION; DIVERSE FUNCTIONS; UBIQUITIN LIGASE | Histone acetylation; Histone acylation; Histone methylation; Histone phosphorylation; Histone sumoylation; Histone ubiquitylation | Acetylation; Alkylation; Chromosomes; Methylation; Phosphorylation; Yeast; core protein; histone; Acylations; Histone acetylation; Histone acylation; Histone methylation; Histone modification; Histone phosphorylation; Histone sumoylation; Histone ubiquitylation; Sumoylation; Ubiquitylation; acylation; cell function; chromatin; histone acetylation; histone methylation; histone modification; histone phosphorylation; histone ubiquitination; nonhuman; protein processing; Saccharomyces cerevisiae; Short Survey; sumoylation; yeast cell; Acylation | English | 2023 | 2023 | 10.1016/j.csbj.2023.02.037 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Inverse Propensity Score-Weighted Analysis of Entecavir and Tenofovir Disoproxil Fumarate in Patients with Chronic Hepatitis B: A Large-Scale Multicenter Study | Tenofovir disoproxil fumarate (TDF) is reportedly superior or at least comparable to entecavir (ETV) in preventing hepatocellular carcinoma (HCC) among chronic hepatitis B (CHB) patients; however, it remains controversial. This study aimed to conduct comprehensive comparisons between the two antivirals. CHB patients initially treated with ETV or TDF between 2012 and 2015 at 20 referral centers in Korea were included. The primary outcome was the cumulative incidence of HCC. The secondary outcomes included death or liver transplantation, liver-related outcome, extrahepatic malignancy, development of cirrhosis, decompensation events, complete virologic response (CVR), seroconversion rate, and safety. Baseline characteristics were balanced using the inverse probability of treatment weighting (IPTW). Overall, 4210 patients were enrolled: 1019 received ETV and 3191 received TDF. During the median follow-ups of 5.6 and 5.5 years, 86 and 232 cases of HCC were confirmed in the ETV and TDF groups, respectively. There was no difference in HCC incidence between the groups both before (p = 0.36) and after IPTW was applied (p = 0.81). Although the incidence of extrahepatic malignancy was significantly higher in the ETV group than in the TDF group before weighting (p = 0.02), no difference was confirmed after IPTW (p = 0.29). The cumulative incidence rates of death or liver transplantation, liver-related outcome, new cirrhosis development, and decompensation events were also comparable in the crude population (p = 0.24-0.91) and in the IPTW-adjusted population (p = 0.39-0.80). Both groups exhibited similar rates of CVR (ETV vs. TDF: 95.1% vs. 95.8%, p = 0.38), and negative conversion of hepatitis B e antigen (41.6% vs. 37.2%, p = 0.09) or surface antigen (2.8% vs. 1.9%, p = 0.10). Compared to the ETV group, more patients in the TDF group changed initial antivirals due to side effects, including decreased kidney function (n = 17), hypophosphatemia (n = 20), and osteoporosis (n = 18). In this large-scale multicenter study, ETV and TDF demonstrated comparable effectiveness across a broad range of outcomes in patients with treatment-naive CHB during similar follow-up periods. | Kim, Jihye; Hur, Moon Haeng; Kim, Seung Up; Kim, Jin-Wook; Sinn, Dong Hyun; Lee, Hyun Woong; Kim, Moon Young; Cheong, Jae Youn; Jung, Yong Jin; Lee, Han Ah; Jin, Young-Joo; Yoon, Jun Sik; Park, Sung-Jae; Lee, Chang Hun; Kim, In Hee; Lee, June Sung; Cho, Young Youn; Kim, Hyung Joon; Park, Soo Young; Seo, Yeon Seok; Oh, Hyunwoo; Jun, Dae Won; Kim, Mi Na; Chang, Young; Jang, Jae Young; Hwang, Sang Youn; Kim, Yoon Jun | Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Coll Med, Seongnam 13620, South Korea; Seoul Natl Univ, Liver Res Inst, Dept Internal Med, Coll Med, Seoul 03080, South Korea; Yonsei Univ, Severance Hosp, Coll Med, Dept Internal Med, Seoul 03722, South Korea; Yonsei Univ, Severance Hosp, Coll Med, Yonsei Liver Ctr, Seoul 03722, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Internal Med, Sch Med, Seoul 06351, South Korea; Yonsei Univ, Gangnam Severance Hosp, Dept Internal Med, Coll Med, Seoul 06273, South Korea; Yonsei Univ, Dept Internal Med, Wonju Coll Med, Wonju 26426, South Korea; Ajou Univ, Dept Gastroenterol, Sch Med, Suwon 16499, South Korea; Seoul Natl Univ, Dept Internal Med, Seoul Metropolitan Govt, Boramae Med Ctr, Seoul 07061, South Korea; Ewha Womans Univ, Dept Internal Med, Coll Med, Seoul 07985, South Korea; Inha Univ, Inha Univ Hosp, Dept Internal Med, Sch Med, Incheon 22332, South Korea; Inje Univ, Dept Gastroenterol & Hepatol, Busan Paik Hosp, Busan 47392, South Korea; Jeonbuk Natl Univ Hosp, Dept Internal Med, Jeonju 54907, South Korea; Inje Univ, Dept Internal Med, Ilsan Paik Hosp, Goyang 10380, South Korea; Chung Ang Univ, Dept Internal Med, Coll Med, Seoul 06973, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Korea Univ, Coll Med, Dept Internal Med, Anam Hosp, Seoul 02841, South Korea; Eulji Univ, Uijeongbu Eulji Med Ctr, Dept Internal Med, Sch Med, Uijongbu 11759, South Korea; Hanyang Univ, Hanyang Univ Hosp, Dept Internal Med, Coll Med, Seoul 04763, South Korea; CHA Univ, CHA Bundang Med Ctr, Dept Internal Med, Seongnam 13496, South Korea; Soonchunhyang Univ, Dept Internal Med, Coll Med, Seoul Hosp, Seoul 04401, South Korea; Dongnam Inst Radiol & Med Sci, Dept Internal Med, Busan 46033, South Korea; Dongnam Inst Radiol & Med Sci, Gastrointestinal Canc Ctr, Busan 46033, South Korea | ; Kim, Sun/L-4239-2013; Kim, Ju/AAV-3029-2020; Kim, Eun Young/JCE-3602-2023; Kim, Yoon/G-6633-2015; Kim, Yong Won/AAA-2134-2022; LEE, HYUN/ABC-6119-2021; Sinn, Dong/JAC-4247-2023; Kim, Jin-Wook/J-5442-2012; Jun, Dae Won/O-4529-2017; Lee, Chang Hun/LHA-3105-2024; Kim, Yoon/J-2746-2012 | 57236802400; 57356094400; 54933821200; 56564054500; 23493891100; 57349302900; 55545239100; 7004933299; 56865094300; 57190980926; 37093233300; 57195953972; 24176295000; 57203056004; 7404143744; 8429951900; 55850994200; 57206212081; 57191674344; 35234912400; 57193555659; 8662222500; 57202910894; 57077241600; 57221679776; 55466667900; 25947520600 | yoonjun@snu.ac.kr; | CANCERS | CANCERS | 2072-6694 | 15 | 11 | SCIE | ONCOLOGY | 2023 | 4.5 | 24.1 | 0.3 | 2025-06-25 | 1 | 2 | entecavir; tenofovir; liver cancer; extrahepatic malignancy; virologic response | HEPATOCELLULAR-CARCINOMA; RISK; ALAFENAMIDE | entecavir; extrahepatic malignancy; liver cancer; tenofovir; virologic response | alanine aminotransferase; alpha fetoprotein; antivirus agent; aspartate aminotransferase; bilirubin; creatinine; entecavir; hepatitis B surface antigen; hepatitis B(e) antigen; interferon; tenofovir disoproxil; adult; Article; autoimmune hepatitis; Child Pugh score; chronic hepatitis B; coinfection; computer assisted tomography; diabetes mellitus; echography; estimated glomerular filtration rate; female; follow up; gene mutation; glomerulus filtration rate; hepatic encephalopathy; hepatitis C; human; hypertension; hypophosphatemia; kidney function; liver cell carcinoma; liver cirrhosis; major clinical study; male; mortality rate; multicenter study; osteoporosis; outcome assessment; phosphate blood level; platelet count; propensity score; prothrombin time; risk factor; seroconversion | English | 2023 | 2023-05-26 | 10.3390/cancers15112936 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Prevalence and Characteristics of Human Papillomavirus Infection in Oropharyngeal Squamous Cell Papilloma | Simple Summary Studies on human papillomavirus (HPV) infection in oropharyngeal squamous papilloma (OPSP) are lacking, although HPV is a critical oncogenic virus for the development of oropharyngeal cancer. This study evaluated the prevalence and characteristics of HPV infection in OPSP and showed a 14.5% overall prevalence. High-risk HPV accounts for 75% of all HPV infections, with HPV16 being the most prevalent genotype, accounting for 58.3% of all HPV infections. There was a trend toward a higher prevalence of high-risk HPV infection in patients with OPSP aged <= 45 years, never-smokers, and those with multifocal diseases, which corresponded with the clinicodemographic profiles of HPV-associated oropharyngeal cancer. These findings could enhance our understanding of HPV infection in OPSP and could be used as valuable epidemiological data for the management of HPV-associated OPSP. Studies on human papillomavirus (HPV) infection in oropharyngeal squamous papilloma (OPSP) are lacking, although HPV infection has been recognized as the primary cause of oropharyngeal cancer for several decades. This study aimed to evaluate the prevalence and characteristics of HPV infections in patients with OPSP. We retrospectively enrolled patients with histologically confirmed OPSP in whom the presence of HPV infections and p16 expression were evaluated. The results of HPV infection in OPSP were analyzed according to the clinicodemographic profiles. Of the 83 patients included in this study, HPV test results were positive in 12 patients, with an overall prevalence of 14.5%. HPV genotypes involved low-risk and high-risk HPV types in three (3.6%) and nine (10.8%) patients, respectively. The most prevalent genotype was HPV16, accounting for 58.3% of all HPV infections. None of the OPSPs showed p16 IHC positivity. There were trends toward a higher prevalence of high-risk HPV infection in patients with OPSP aged <= 45 years, never-smokers, and those with multifocal diseases. These findings could enhance our understanding of HPV infection in OPSP and be used as valuable epidemiological data for the management of HPV-associated OPSP and regarding the possible efficacy of HPV vaccinations in OPSP. | Ahn, Dongbin; Kwak, Ji-Hye; Lee, Gil-Joon; Sohn, Jin-Ho | Kyungpook Natl Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Daegu 41944, South Korea | 44761055400; 57393330600; 57193082568; 55165818100 | godlikeu@naver.com; | CANCERS | CANCERS | 2072-6694 | 15 | 3 | SCIE | ONCOLOGY | 2023 | 4.5 | 24.1 | 0.3 | 2025-06-25 | 3 | 2 | squamous papilloma; human papillomavirus; prevalence; genotype | ORAL HUMAN-PAPILLOMAVIRUS; SINONASAL PAPILLOMAS; HEAD; CANCER; EPIDEMIOLOGY; MUCOSAL; LESIONS | genotype; human papillomavirus; prevalence; squamous papilloma | protein p16; adult; Article; clinical feature; cohort analysis; demographics; disease association; female; genotype; high risk population; histopathology; human; Human papillomavirus type 16; human tissue; low risk population; major clinical study; male; never smoker; nonhuman; oropharyngeal squamous cell papilloma; oropharynx tumor; papilloma; papillomavirus infection; prevalence; protein expression; retrospective study; Wart virus | English | 2023 | 2023-02 | 10.3390/cancers15030810 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Meeting Abstract | Suppression of the canonical TGF-β signaling via SMAD3/4 renders EGFR-mutant lung adenocarcinoma resistant to EGFR-TKIs | Bae, Eunjin; Yoon, Jeonghwan; Nagafuchi, Yasuo; Makino, Yojiro; Tamura, Atsumi; Lee, Inkyu; Han, Jinsoo; Ju, Jihyun; Sukeda, Aoi; Nagao, Toshitaka; Kato, Mitsuyasu; Fujio, Keishi; Kuroda, Masahiko; Ohira, Tatsuo; Ikeda, Norihiko; Mamura, Mizuko | Tokyo Med Univ, Dept Mol Pathol, Tokyo, Japan; Kyungpook Natl Univ Hosp, Biomed Res Inst, Daegu, South Korea; Univ Tsukuba, Grad Sch Comprehens Human Sci, Dept Expt Pathol, Tsukuba, Ibaraki, Japan; Univ Tsukuba, Fac Med, Tsukuba, Japan; Konkuk Univ, Coll Vet Med, Lab Anim Med, Seoul, South Korea; Tokyo Med Univ, Dept Surg, Tokyo, Japan; Catholic Univ, Seoul St Mary Hosp, Dept Rheumatol, Seoul, South Korea; Tokyo Med Univ, Dept Anat Pathol, Tokyo, Japan; Univ Tokyo, Grad Sch Med, Dept Allergy & Rheumatol, Tokyo, Japan | Nagafuchi, Yasuo/Y-9083-2019; Lee, Inkyu/F-1656-2019 | CANCER SCIENCE | CANCER SCI | 1347-9032 | 1349-7006 | 114 | SCIE | ONCOLOGY | 2023 | 4.5 | 24.1 | 0 | English | 2023 | 2023-02 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Editorial Material | A novel strategy employing the flavonoid fisetin to halt the progression of renal fibrosis in obstructive nephropathy | Kwon, Tae-Hwan | Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, 680 Gukchaebosang Ro, Daegu 41944, South Korea | Kwon, Tae-Hwan/ABA-1981-2020 | 7202206089 | thkwon@knu.ac.kr; | KIDNEY RESEARCH AND CLINICAL PRACTICE | KIDNEY RES CLIN PRAC | 2211-9132 | 2211-9140 | 42 | 3 | SCIE | UROLOGY & NEPHROLOGY | 2023 | 2.9 | 24.2 | 1.82 | 2025-06-25 | 2 | 3 | anthocyanin; chalcone derivative; cisplatin; creatinine; endothelin 1; fisetin; glucagon like peptide 1; mitogen activated protein kinase; mycotoxin; reactive oxygen metabolite; small interfering RNA; stromal cell derived factor 1; transforming growth factor beta; animal experiment; animal model; apoptosis; cell differentiation; creatinine blood level; diabetic nephropathy; Editorial; end stage renal disease; epithelial mesenchymal transition; estimated glomerular filtration rate; female; glomerulonephritis; glomerulus filtration rate; immune response; inflammation; intracellular signaling; kidney disease; kidney fibrosis; macrophage; metabolic acidosis; mouse; nephrosclerosis; nephrotoxicity; nonhuman; oxidative stress; prevalence; rat; renal protection; renin angiotensin aldosterone system; structure activity relation; tissue perfusion; tumor associated leukocyte; tumor growth; ureter obstruction | English | 2023 | 2023-05 | 10.23876/j.krcp.23.095 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Review | Autophagy and regulation of aquaporins in the kidneys | Aquaporins (AQPs) are water channel proteins that facilitate the transport of water molecules across cell membranes. To date, seven AQPs have been found to be expressed in mammal kidneys. The cellular localization and regulation of the transport properties of AQPs in the kidney have been widely investigated. Autophagy is known as a highly conserved lysosomal pathway, which degrades cytoplasmic components. Through basal autophagy, kidney cells maintain their functions and structure. As a part of the adaptive responses of the kidney, autophagy may be altered in response to stress conditions. Recent studies revealed that autophagic degradation of AQP2 in the kidney collecting ducts leads to impaired urine concentration in animal models with polyuria. Therefore, the modulation of autophagy could be a therapeutic approach to treat water balance disorders. However, as autophagy is either protective or deleterious, it is crucial to establish an optimal condition and therapeutic window where autophagy induction or inhibition could yield beneficial effects. Further studies are needed to understand both the regulation of autophagy and the interaction between AQPs and autophagy in the kidneys in renal diseases, including nephrogenic diabetes insipidus. | Guo, Xiangdong; Kong, Yonglun; Kwon, Tae-Hwan; Li, Chunling; Wang, Weidong | Sun Yat Sen Univ, Zhongshan Sch Med, Dept Pathophysiol, 74 Zhongshan Rd 2, Guangzhou 510080, Guangdong, Peoples R China; Sun Yat Sen Univ, Zhongshan Sch Med, Dept Physiol, Guangzhou, Peoples R China; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu, South Korea | ; Kwon, Tae-Hwan/ABA-1981-2020 | 57226423962; 57195964179; 7202206089; 7501681643; 57190885389 | wangwd6@mail.sysu.edu.cn; | KIDNEY RESEARCH AND CLINICAL PRACTICE | KIDNEY RES CLIN PRAC | 2211-9132 | 2211-9140 | 42 | 6 | SCIE | UROLOGY & NEPHROLOGY | 2023 | 2.9 | 24.2 | 0.22 | 2025-06-25 | 2 | 2 | Aquaporins; Autophagy; Nephrogenic diabetes insipidus; Urine concentration defect | INDUCED DOWN-REGULATION; NEPHROGENIC DIABETES-INSIPIDUS; ENDOPLASMIC-RETICULUM STRESS; MEDULLARY COLLECTING DUCT; WATER CHANNEL EXPRESSION; RENAL AQUAPORINS; AQP2 EXPRESSION; RAT; LITHIUM; PHOSPHORYLATION | Aquaporins; Autophagy; Nephrogenic diabetes insipidus; Urine concentration defect | aquaporin; aquaporin 1; aquaporin 2; aquaporin 3; aquaporin 4; chloroquine; glycogen synthase kinase 3beta; phosphatidylinositol 3 kinase; reactive oxygen metabolite; sequestosome 1; serine threonine protein kinase ULK1; vasopressin; antibody labeling; autophagosome; autophagy (cellular); cell junction; cell proliferation; cell survival; cellular distribution; down regulation; endoplasmic reticulum; hypercalcemia; hypokalemia; kidney disease; light chain; lysosome; mass spectrometry; microautophagy; mortality rate; nephrogenic diabetes insipidus; nonhuman; oxidative stress; polydipsia; polyuria; protein expression; protein phosphorylation; proteomics; Review; RNA sequencing; signal transduction; ubiquitination; water absorption | English | 2023 | 2023-11 | 10.23876/j.krcp.22.247 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Effect of donor-recipient size mismatch on long-term graft survival in pediatric kidney transplantation: a multicenter cohort study | Background: Donor-recipient size mismatching is commonly occurs in pediatric kidney transplantation (KT). However, its effect on graft survival remains unknown. This study aimed to determine the effect of donor-recipient size mismatch on the long-term survival rate of transplant kidneys in pediatric KT. Methods: A total of 241 pediatric patients who received KT were enrolled. The medical records of all patients were retrospectively re-viewed, and the correlation between donor-recipient size mismatch and graft function and long-term graft outcome was analyzed ac-cording to donor-recipient size mismatch. Results: Recipients and donors' mean body weight at the time of KT were 34.31 +/- 16.85 and 56.53 +/- 16.73 kg, respectively. The mean follow-up duration was 96.49 +/- 52.98 months. A significant positive correlation was observed between donor-recipient body weight ratio (DRBWR) or donor-recipient body surface area ratio (DRBSR) and graft function until 1 year after KT. However, this cor-relation could not be confirmed at the last follow-up. The results of long-term survival analysis using Fine and Gray's subdistribution hazard model showed no significant difference of the survival rate of the transplant kidney according to DRBWR or DRBSR. Conclusion: Donor-recipient size mismatch in pediatric KT is not an important factor in determining the long-term prognosis of trans-plant kidneys. | Park, Min Ji; Baek, Hee Sun; Song, Ji Yeon; Choi, Naye; Ahn, Yo Han; Kang, Hee Gyung; Cho, Min Hyun | Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Yeungnam Univ, Coll Med, Dept Pediat, Daegu, South Korea; Pusan Natl Univ, Sch Med, Pusan Natl Univ Childrens Hosp, Dept Pediat, Yangsan, South Korea; Seoul Natl Univ, Coll Med, Dept Pediat, Seoul Natl Univ Childrens Hosp, Seoul, South Korea; Seoul Natl Univ, Med Res Ctr, Kidney Res Inst, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Pediat, 130 Dongdeok Ro, Daegu 41944, South Korea | ; CHOI, NAYE/KCL-4467-2024 | 57425372600; 56689379700; 57204058871; 57210441897; 57219957477; 7404071546; 7401727726 | chomh@knu.ac.kr; | KIDNEY RESEARCH AND CLINICAL PRACTICE | KIDNEY RES CLIN PRAC | 2211-9132 | 2211-9140 | 42 | 6 | SCIE | UROLOGY & NEPHROLOGY | 2023 | 2.9 | 24.2 | 0 | 2025-06-25 | 0 | 0 | Donor; Kidney transplantation; Pediatrics; Recipient | RENAL-TRANSPLANTATION; KOREAN CHILDREN; OUTCOMES; WEIGHT; INFANTS; GROWTH; LENGTH; VOLUME | Donor; Kidney transplantation; Pediatrics; Recipient | azathioprine; cyclosporine; methylprednisolone; mycophenolate mofetil; prednisolone; tacrolimus; Article; body mass; body surface; body weight; child; chronic kidney failure; cohort analysis; cold; delayed graft function; dialysis; donor recipient size mismatch; estimated glomerular filtration rate; female; focal glomerulosclerosis; follow up; glomerulus filtration rate; graft failure; graft recipient; graft survival; hospital readmission; hospitalization; human; ischemia time; kidney function; kidney graft; kidney transplantation; living donor; long term survival; major clinical study; male; medical record review; multicenter study; pediatric kidney transplantation; preschool child; retrospective study; survival analysis; survival rate; ultrafiltration | English | 2023 | 2023-11 | 10.23876/j.krcp.23.170 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Evaluating the Safety and effectivenesS in adult KorEaN patients treated with Tolvaptan for management of autosomal domInAnt poLycystic kidney disease (ESSENTIAL): short-term outcomes during the titration period | Background: Tolvaptan reduces height-adjusted total kidney volume (htTKV) and renal function decline in autosomal dominant poly -cystic kidney disease (ADPKD). This study was aimed at investigating the efficacy and safety of tolvaptan in Korean patients with ADP-KD during the titration period.Methods: This study is a multicenter, single-arm, open-label phase 4 study. We enrolled 108 patients with ADPKD (age, 19-50 years) with an estimated glomerular filtration rate (eGFR) of >30 mL/min/1.73 m2 and factors defined as indicative of rapid disease progres-sion. After tolvaptan titration, we evaluated efficacy and side effects and assessed factors associated with the effects.Results: After titration for 4 weeks, eGFR and htTKV decreased by 6.4 +/- 7.9 mL/min/1.73 m2 and 16 +/- 45 mL/m, respectively. No se-rious adverse drug reactions were observed during the titration period. The greatest eGFR decline was observed in the first week, with a starting tolvaptan dose of 45 mg. Multivariate linear regression for htTKV decline showed that the greater the change in urine osmo-lality (Uosm), the greater the decrease in htTKV (beta, 0.436; p = 0.009) in the 1D group stratified by the Mayo Clinic image classification. Higher baseline eGFR was related to a higher htTKV reduction rate in the 1E group (beta, -0.642; p = 0.009).Conclusion: We observed short-term effects and safety during the tolvaptan titration period. The decline of htTKV can be predicted as a short-term effect of tolvaptan by observing Uosm changes from baseline to end of titration in 1D and baseline eGFR in 1E groups. | Huh, Hyuk; Kim, Yong Soo; Chung, Wookyung; Kim, Yong Lim; Kim, Yaerim; Han, Seungyeup; Jung, Yeonsoon; Na, Ki Young; Lee, Kyu Beck; Oh, Yun Kyu; Park, Hyeong Cheon; Han, Seung Hyeok; Yoo, Tae Hyun; Kim, Yeong Hoon; Kim, Soo Wan; Lee, Kang Wook; Park, Hayne Cho; Kim, Sung Gyun; Kim, Hyunsuk; Lee, Chang Hwa; Bae, Kyongtae T.; Oh, Kook Hwan; Ahn, Curie; Ryu, Hyun Jin; Kim, Yong Chul | Seoul Natl Univ Hosp, Dept Internal Med, 101 Daehak Ro, Seoul 03080, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Dept Internal Med, Seoul, South Korea; Gachon Univ, Dept Internal Med, Gil Med Ctr, Inchon, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Keimyung Univ, Dept Internal Med, Dongsan Hosp, Daegu, South Korea; Kosin Univ, Dept Internal Med, Gospel Hosp, Busan, South Korea; Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; Kangbuk Samsung Hosp, Dept Internal Med, Seoul, South Korea; SMG SNU Boramae Med Ctr, Dept Internal Med, Seoul, South Korea; Gangnam Severance Hosp, Dept Internal Med, Seoul, South Korea; Severance Hosp, Dept Internal Med, Seoul, South Korea; Inje Univ, Dept Internal Med, Busan Paik Hosp, Busan, South Korea; Chonnam Natl Univ, Dept Internal Med, Med Sch, Gwangju, South Korea; Chungnam Natl Univ Hosp, Dept Internal Med, Daejeon, South Korea; Hallym Univ, Dept Internal Med, Kangnam Sacred Heart Hosp, Seoul, South Korea; Hallym Univ, Dept Internal Med, Sacred Heart Hosp, Anyang, South Korea; Hallym Univ, Dept Internal Med, Chuncheon Sacred Heart Hosp, Chunchon, South Korea; Hanyang Univ Seoul Hosp, Dept Internal Med, Seoul, South Korea; Univ Hong Kong, Sch Clin Med, Dept Diagnost Radiol, Hong Kong, Peoples R China; Natl Med Ctr, Dept Internal Med, Seoul, South Korea | ; Kim, Soo-Yeon/ADR-9663-2022; Han, Seung/K-4559-2018; Oh, Yun/J-5542-2012; Na, Ki/J-5456-2012; Kim, Honghyok/LDF-5356-2024; Oh, Kook-Hwan/MDS-5373-2025; Han, Seung Seok/HGD-2825-2022; Kim, Nan/T-8627-2019; Kim, Yong-Lim/AGK-3172-2022; Kim, Sang/J-5399-2012; Kim, Tae-Hee/AAN-9079-2021; Kim, Hyun-Jung/ABA-3655-2021; Han, Seung Hyeok/K-4559-2018 | 56124383900; 57225107409; 56963220900; 55633533600; 57202790600; 24281360600; 35242305100; 35238267600; 57951151600; 15019793000; 58835435400; 18233343300; 7101746143; 7410196419; 56108124300; 7501514537; 34771965700; 34770030300; 57194217507; 55770260300; 7102682002; 7402728369; 59056618600; 56029712400; 57026583000 | hdutopia@gmail.com;imyongkim@gmail.com; | KIDNEY RESEARCH AND CLINICAL PRACTICE | KIDNEY RES CLIN PRAC | 2211-9132 | 2211-9140 | 42 | 2 | SCIE | UROLOGY & NEPHROLOGY | 2023 | 2.9 | 24.2 | 0.51 | 2025-06-25 | 2 | 2 | Clinical trial phase IV; Polycystic kidney autosomal dominant; Tolvaptan | VOLUME; ADPKD | Clinical trial phase IV; Polycystic kidney autosomal dominant; Tolvaptan | alanine aminotransferase; aspartate aminotransferase; bilirubin; polycystin 1; tolvaptan; adult; Article; body mass; colorimetry; creatinine blood level; diastolic blood pressure; disease exacerbation; drug efficacy; drug therapy; drug withdrawal; dyslipidemia; echography; estimated glomerular filtration rate; female; human; hypertension; hypertransaminasemia; kidney function; kidney polycystic disease; Korean (people); liver toxicity; major clinical study; male; multicenter study; nocturia; nuclear magnetic resonance; pain severity; patient-reported outcome; phase 4 clinical trial; polyuria; short term outcome; short term survival; sodium blood level; systolic blood pressure; titrimetry; urinary urgency; urine osmolality | English | 2023 | 2023-03 | 10.23876/j.krcp.22.024 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Shortening of primary cilia length is associated with urine concentration in the kidneys | Background: The primary cilium, a microtubule-based cellular organelle present in certain kidney cells, functions as a mechano-sen-sor to monitor fluid flow in addition to various other biological functions. In kidneys, the primary cilia protrude into the tubular lumen and are directly exposed to pro-urine flow and components. However, their effects on urine concentration remain to be defined. Here, we investigated the association between primary cilia and urine concentration. Methods: Mice either had free access to water (normal water intake, NWI) or were not allowed access to water (water deprivation, WD). Some mice received tubastatin, an inhibitor of histone deacetylase 6 (HDAC6), which regulates the acetylation of & alpha;-tubulin, a core protein of microtubules. Results: WD decreased urine output and increased urine osmolality, concomitant with apical plasma membrane localization of aqua-porin 2 (AQP2) in the kidney. After WD, compared with after NWI, the lengths of primary cilia in renal tubular epithelial cells were shortened and HDAC6 activity increased. WD induced deacetylation of & alpha;-tubulin without altering & alpha;-tubulin levels in the kidney. Tubas-tatin prevented the shortening of cilia through increasing HDAC6 activity and consequently increasing acetylated & alpha;-tubulin expression. Furthermore, tubastatin prevented the WD-induced reduction of urine output, urine osmolality increase, and apical plasma mem-brane localization of AQP2. Conclusions: WD shortens primary cilia length through HDAC6 activation and & alpha;-tubulin deacetylation, while HDAC6 inhibition blocks the WD-induced changes in cilia length and urine output. This suggests that cilia length alterations are involved, at least in part, in the regulation of body water balance and urine concentration. | Kong, Min Jung; Han, Sang Jun; Seu, Sung Young; Han, Ki-Hwan; Lipschutz, Joshua H.; Park, Kwon Moo | Kyungpook Natl Univ, Cardiovasc Res Inst, Sch Med, Dept Anat,Plus BK21, Daegu, South Korea; Pukyong Natl Univ, Coll Fisheries Sci, Dept Biotechnol, Busan, South Korea; Ewha Womans Univ, Dept Anat, Sch Med, Seoul, South Korea; Med Univ South Carolina, Dept Med, Charleston, SC USA; Ralph H Johnson Vet Affairs Med Ctr, Dept Med, Charleston, SC USA; Kyungpook Natl Univ, Sch Med, Dept Anat, 680 Gukchaebosang Ro, Daegu 41944, South Korea | 57194730911; 57202122005; 57194267679; 14622504200; 6701696189; 8785448200 | kmpark@knu.ac.kr; | KIDNEY RESEARCH AND CLINICAL PRACTICE | KIDNEY RES CLIN PRAC | 2211-9132 | 2211-9140 | 42 | 3 | SCIE | UROLOGY & NEPHROLOGY | 2023 | 2.9 | 24.2 | 1.52 | 2025-06-25 | 6 | 6 | Primary cilia; Aquaporin 2; Histone deacetylase 6; Osmolality; Water deprivation | ISCHEMIA/REPERFUSION INJURY; HDAC6 ACTIVITY; FLOW; CELLS; MICROTUBULES; INHIBITION; DYNAMICS; FIBROSIS; TUBULIN; STRESS | Aquaporin 2; Histone deacetylase 6; Osmolality; Primary cilia; Water deprivation | alpha tubulin; aquaporin 2; beta actin; broxuridine; histone deacetylase 6; osmium tetraoxide; uvomorulin; animal experiment; animal model; Article; BrdU assay; cell proliferation; epithelium cell; immunofluorescence; kidney; kidney concentrating capacity; kidney tubule; male; microtubule; micturition; mouse; nonhuman; primary cilium; protein expression; urine biochemistry; urine osmolality; urine volume; water deprivation; Western blotting | English | 2023 | 2023-05 | 10.23876/j.krcp.22.274 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Editorial Material | The fate of nitrogen of ammonium phosphate fertilizers: A blind spot | Ammonium phosphate fertilizers are a common phosphorus (P) source for crops, namely monoammonium phosphate, diammonium phosphate, and ammonium polyphosphate. Despite containing appreciable nitrogen (N), ammonium phosphate fertilizers are generally considered P fertilizers. However, the approximately 8.5 million Mg N co-applied with P annually as ammonium phosphate fertilizers represents 8% of global N fertilizer input flux to agroecosystems. Despite this, a systematic review of the literature revealed only one direct assessment of N losses from ammonium phosphate fertilizers. An additional five studies reported NO3-N leaching and N2O-N emissions from soils fertilized with ammonium phosphates, but inadvertently as observations from failed or control treatments that are confounded (e.g., not accounting for non-fertilizer contributions to N losses). The magnitude and fate of N co-applied with P in ammonium phosphate fertilizers is a blind spot in agroecosystem N budgets and environmental footprints that necessitates quantification. | Margenot, Andrew J.; Lee, Jeonggu | Univ Illinois, Dept Crop Sci, Urbana, IL USA; Univ Illinois, Inst Sustainabil Energy & Environm, Agroecosystem Sustainabil Ctr, Urbana, IL USA; Kyungpook Natl Univ, Dept Appl Biosci, Daegu, South Korea; Univ Illinois, Dept Crop Sci, Urbana, IL 61801 USA | Margenot, Andrew/C-9869-2016; Lee, Jeonggu/LDG-2186-2024 | 56145435900; 57204356196 | margenot@illinois.edu; | AGRICULTURAL & ENVIRONMENTAL LETTERS | AGR ENV LETT | 2471-9625 | 8 | 2 | SCIE | AGRICULTURE, MULTIDISCIPLINARY;ENVIRONMENTAL SCIENCES | 2023 | 2.3 | 24.2 | 3.59 | 2025-06-25 | 6 | 6 | OXIDE EMISSIONS; N2O EMISSIONS; SOIL; NITRIFICATION; EFFICIENCY; CROP | English | 2023 | 2023-12 | 10.1002/ael2.20116 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Differences in facial soft tissue deviations in Class III patients with different types of mandibular asymmetry: A cone-beam computed tomography study | Objective: This study assessed the differences in soft tissue deviations of the nose, lips, and chin between different mandibular asymmetry types in Class III patients. Methods: Cone-beam computed tomography data from 90 Class III patients with moderate-to-severe facial asymmetry were investigated. The sample was divided into three groups based on the extent of mandibular rolling, yawing, and translation. Soft tissue landmarks on the nose, lips, and chin were investigated vertically, transversely, and anteroposteriorly. A paired t test was performed to compare variables between the deviated (Dv) and nondeviated (NDv) sides, and one-way analysis of variance with Tukey's post-hoc test was performed for intergroup comparisons. Pearson's correlation coefficient was calculated to assess the relationship between the soft and hard tissue deviations. Results: The roll-dominant group showed significantly greater differences in the vertical positions of the soft tissue landmarks between the Dv and NDv than other groups (P < 0.05), whereas the yaw-dominant group exhibited larger differences in the transverse and anteroposterior directions (P < 0.05). Moreover, transverse lip cant was correlated with the menton (Me) deviation and mandibular rolling in the roll-dominant group (P < 0.001); the angulation of the nasal bridge or philtrum was correlated with the Me deviation and mandibular yawing in the yaw-dominant group (P < 0.01). Conclusions: The three-dimensional deviations of facial soft tissue differed based on the mandibular asymmetry types in Class III patients with similar amounts of Me deviation. A precise understanding of soft tissue deviation in each asymmetry type would help achieve satisfactory facial esthetics. | Kim, Ho-Jin; Noh, Hyung-Kyu; Park, Hyo-Sang | Kyungpook Natl Univ, Sch Dent, Dept Orthodont, Daegu, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Orthodont, 2175 Dalgubeol Daero, Daegu 41940, South Korea | 57200084686; 57208229164; 55754836800 | parkhs@knu.ac.kr; | KOREAN JOURNAL OF ORTHODONTICS | KOREAN J ORTHOD | 2234-7518 | 2005-372X | 53 | 6 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2023 | 2.6 | 24.4 | 0.35 | 2025-06-25 | 2 | 1 | Cone-beam computed tomography; Facial asymmetry; Mandibular asymmetry type; Soft tissue deviation | 3-DIMENSIONAL ANALYSIS; ORTHOGNATHIC SURGERY; CLASSIFICATION; OSTEOTOMY; CONTOUR; CANT; HARD | Cone-beam computed tomography; Facial asymmetry; Mandibular asymmetry type; Soft tissue deviation | English | 2023 | 2023-11 | 10.4041/kjod23.106 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Differences in positions of cone-beam computed tomography landmarks in patients with skeletal Class III facial asymmetry according to midsagittal planes | Objective: This study aimed to clarify differences in the positions of cone-beam computed tomography (CBCT) landmarks according to different midsagittal planes (MSPs) in patients with skeletal Class III facial asymmetry. Methods: Pre-treatment CBCT data from 60 patients with skeletal Class III were used. The patients were classified into symmetric (menton deviations of 4 mm) groups. Six MSPs were established based on previous studies, and three-dimensional analyses were performed for the planes in both the groups. The measurement outcomes were compared statistically. Results: A statistically significant interaction (p < 0.01) was observed between MSPs and facial asymmetry. No significant differences were observed among MSPs in the symmetric group. However, significant differences in linear measurements were identified among MSPs in the asymmetric group. Specifically, the upper facial MSP revealed both maxillary and mandibular transverse asymmetries. On the other hand, anterior nasal spine (ANS)associated MSP could not identify maxillary asymmetry. Furthermore, the menton deviation was approximately 3 mm lower when estimated using the ANS-associated MSP than that using upper facial MSP. Conclusions: The choice of MSP can significantly affect treatment outcomes while diagnosing patients with asymmetry. Therefore, care should be taken when selecting MSP in clinical practice. | Noh, Hyung-Kyu; Kim, Ho-Jin; Park, Hyo-Sang | Kyungpook Natl Univ, Sch Dent, Dept Orthodont, 2175 Dalgubeol Daero, Daegu 41940, South Korea | 57208229164; 57200084686; 55754836800 | parkhs@knu.ac.kr; | KOREAN JOURNAL OF ORTHODONTICS | KOREAN J ORTHOD | 2234-7518 | 2005-372X | 53 | 4 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2023 | 2.6 | 24.4 | 1.06 | 2025-06-25 | 2 | 3 | Facial asymmetry; Midsagittal plane; Cone-beam computed tomography; Diagnosis | TRANSVERSE DENTAL COMPENSATION; 3-DIMENSIONAL ANALYSIS; DISCREPANCIES | Cone-beam computed tomography; Diagnosis; Facial asymmetry; Midsagittal plane | adult; article; clinical practice; cone beam computed tomography; controlled study; face asymmetry; female; human; major clinical study; male; mandible; maxilla; outcome assessment; spine | English | 2023 | 2023-07 | 10.4041/kjod23.015 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effects of 4-hexylresorcinol on facial skeletal development in growing rats: Considerations for diabetes | Objective: To investigate the long-term effects of 4-hexylresorcinol (4HR) on facial skeletal growth in growing male rats, with a focus on diabetic animal models. Methods: Forty male rats were used. Of them, type 1 diabetes mellitus was induced in 20 animals by administering 40 mg/kg streptozotocin (STZ), and they were assigned to either the STZ or 4HR-injected group (STZ/4HR group). The remaining 20 healthy rats were divided into control and 4HR groups. We administered 4HR subcutaneously at a weekly dose of 10 mg/kg until the rats were euthanized. At 16 weeks of age, whole blood was collected, and micro computed tomography of the skull and femur was performed. Results: All craniofacial linear measurements were smaller in the STZ group than in the control group. The mandibular molar width was significantly smaller in the 4HR group than in the control group (P = 0.031) but larger in the STZ/4HR group than in the STZ group (P = 0.011). Among the diabetic animals, the STZ/4HR group exhibited significantly greater cortical bone thickness, bone mineral density, and bone volume than the STZ group. Serum testosterone levels were also significantly higher in the STZ/4HR group than in the STZ group. Conclusions: 4HR administration may have divergent effects on mandibular growth and bone mass in healthy and diabetic rats. In the context of diabetes, 4HR appears to have beneficial effects, potentially through the modulation of mitochondrial respiration. | Jeong, Hannah; Kim, Jwa-Young; Che, Xiangguo; Choi, Je-Yong; Jang, Insan; Kim, Seong-Gon | Gangneung Wonju Natl Univ, Coll Dent, Dept Orthodont, 7 Jukheon Gil, Kangnung 25457, South Korea; Hallym Univ, Med Ctr, Dept Oral & Maxillofacial Surg, Kangnam Sacred Heart Hosp, Seoul, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Korea Mouse Phenotyping Ctr, Sch Med,Dept Biochem & Cell Biol, Daegu, South Korea; Gangneung Wonju Natl Univ, Coll Dent, Dept Oral & Maxillofacial Surg, Kangnung, South Korea | Kim, Sung-Soo/ABD-3771-2021; Choi, Je-Yong/AAR-7334-2021 | 58695429200; 35368445600; 54792660600; 7501391068; 26767897900; 27171913700 | insan@gwnu.ac.kr; | KOREAN JOURNAL OF ORTHODONTICS | KOREAN J ORTHOD | 2234-7518 | 2005-372X | 53 | 6 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2023 | 2.6 | 24.4 | 1.06 | 2025-06-25 | 2 | 3 | 4-hexylresorcinol; Micro-computed tomography; Diabetes mellitus; Testosterone | MITOCHONDRIAL DYNAMICS; GROWTH; TESTOSTERONE | 4-hexylresorcinol; Diabetes mellitus; Micro-computed tomography; Testosterone | English | 2023 | 2023-11 | 10.4041/kjod23.091 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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