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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Tunability of the self-assemblies of porous polygon-like zinc cobaltite architectures using mixed solvents for high-performance supercapacitors | The specific morphology and unique properties of functional materials attracts researchers to explore their applicability in diverse applications. The formation mechanism of the solvent-dependent controlled morphologies of two different self-assemblies of ZnCo2O4 microstructures has been demonstrated. Polygon-like shapes are formed by the self-assemblies of porous nanoparticles, while polygons formed via a similar self-assembly process by nanosheets instead of nanoparticles. The physicochemical properties such as the structure, surface properties and morphologies of both samples were studied and compared. The electrochemical properties of the supercapacitor based on ZnCo2O4 microstructures were investigated using cyclic voltammetry, charge-discharge characteristics, and impedance spectroscopy methods. The cyclic stability of the synthesized electrode over 4000 cycles was studied. A comparison of the electrochemical studies showed the enhanced performance of the polygons with a porous structure (areal capacitance of 24.4 mF cm(-2) at 50 mu A cm(-2)) when compared to its counterpart (areal capacitance of 20.1 mF cm(-2) at 50 mu A cm(-2)). | Gedi, Sreedevi; Manne, Ravi; Manjula, G.; Reddy, L. Veeranjaneya; Reddy, C. Parthasaradhi; Marraiki, Najat; Kim, Woo Kyoung; Mallikarjuna, K.; Reddy, M. Siva Pratap | Yeungnam Univ, Sch Chem Engn, Gyongsan 38541, Gyeongbuk, South Korea; Chemtex Environm Lab, Port Arthur, TX USA; Sri Venkateswara Coll Engn, Dept Phys, Tirupati 517520, Andhra Pradesh, India; Yogi Vemana Univ, Dept Microbiol, Kadapa 516005, Andhra Pradesh, India; Vel Tech Rangarajan Dr Sagunthala R&D Inst Sci &, Dept Phys, Chennai, Tamil Nadu, India; King Saudi Univ, Coll Sci, Dept Bot & Microbiol, POB 2455, Riyadh 11451, Saudi Arabia; Siddharth Inst Engn & Technol, Dept Phys, Puttur 517528, India; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea | Lebaka, Reddy/E-7347-2016; Gangarapu, Manjula/JSK-4986-2023; Koduru, Mallikarjuna/H-9902-2013; C, Parthasaradhi Reddy/AAT-6078-2020; REDDY, C. PARTHASARADHI/AAT-6078-2020; Manne, Ravi/AAN-3408-2021 | 56524575900; 57221720115; 59087077100; 9037435100; 56540048800; 34168158100; 56367339200; 44861376300; 6504345678 | wkim@ynu.ac.kr;mallikar999@gmail.com;dr.mspreddy@gmail.com; | JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS | J PHYS CHEM SOLIDS | 0022-3697 | 1879-2553 | 163 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;PHYSICS, CONDENSED MATTER | 2022 | 4 | 33.6 | 0.53 | 2025-06-25 | 5 | 7 | Solvent-variation; Zinc cobaltite; Polygons; Porous structures; Supercapacitors | OXIDE COMPOSITE; TRANSITION; STORAGE; MICROSPHERES; NANOSHEETS; FILM | Polygons; Porous structures; Solvent-variation; Supercapacitors; Zinc cobaltite | Capacitance; Cobalt compounds; Cyclic voltammetry; Electric discharges; Electrochemical impedance spectroscopy; Functional materials; Geometry; Microstructure; Morphology; Nanoparticles; Physicochemical properties; Porosity; Self assembly; Spectroscopic analysis; Supercapacitor; Zinc; Zinc compounds; Diverse applications; Formation mechanism; Mixed solvent; Performance; Polygon; Porous structures; Property; Solvent-variation; Tunabilities; Zinc cobaltite; Solvents | English | 2022 | 2022-04 | 10.1016/j.jpcs.2022.110587 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Problematic smartphone use and functional somatic symptoms among adolescents: Mediating roles of depressive symptoms and peer relationships by gender | This study explored the relationship between problematic smartphone use and depressive symptoms, peer relationships, and functional somatic symptoms with a representative sample of Korean male and female adolescents using serial multiple mediation models. The results identified the mediating effect of depressive symptoms and peer relationships for males in the association between problematic smartphone use and FSS. The serial mediating effect of the two mediators was also verified in the model for males. However, in the model for females, only depressive symptoms mediated the relationship between problematic smartphone use and FSS. The findings suggest that parents and professionals should assess adolescents with problematic smartphone use for the risk of FSS when depressive symptoms develop. Schools should also provide programs to build positive peer relationships to reduce FSS. | Bae, Eun Jung; Kim, Da Eun; Sagong, Hae; Yoon, Ju Young | Seoul Natl Univ, Coll Nursing, Seoul, South Korea; Kyungpook Natl Univ, Res Inst Nursing Sci, Coll Nursing, Daegu, South Korea; Auburn Univ, Sch Nursing, Auburn, AL USA; Seoul Natl Univ, Res Inst Nursing Sci, Seoul, South Korea; Seoul Natl Univ, Coll Nursing, Ctr Human Caring Nurse Leaders Future Brain Korea, Seoul, South Korea; Seoul Natl Univ, Coll Nursing, 103 Daehak Ro, Seoul 03080, South Korea | Bae, Eun Jung/CAH-8258-2022 | 57194637835; 57197746076; 57201527227; 55363051400 | yoon26@snu.ac.kr; | ARCHIVES OF PSYCHIATRIC NURSING | ARCH PSYCHIAT NURS | 0883-9417 | 1532-8228 | 40 | SCIE;SSCI | NURSING;PSYCHIATRY | 2022 | 2.3 | 33.7 | 0.94 | 2025-06-25 | 5 | 6 | Problematic smartphone use; Functional somatic symptoms; Adolescents; School health | RISK-FACTORS; ANXIETY; ADDICTION; CONSEQUENCES; ASSOCIATIONS; PERSISTENCE; PAIN | Adolescents; Functional somatic symptoms; Problematic smartphone use; School health | English | 2022 | 2022-10 | 10.1016/j.apnu.2022.04.003 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Performance Measurements of Photodiodes for X-Ray Detection | The X-ray free-electron laser (XFEL) at the Pohang Accelerator Laboratory (PAL), Pohang, South Korea, provides X-ray energies of up to 15 keV depending on the experimental purpose. Silicon-based devices have been used as diagnostic devices and detectors for X-rays in experimental stations. Considering recent domestic and international circumstances, developing silicon-based detectors in-house is necessary. We developed a silicon p-intrinsic-n (PIN) photodiode (PD) for X-ray detection, and its performance was investigated and compared with that of a commercial PD used in the PAL-XFEL. The PD was designed to be 1 cm x 1 cm in size, and it used the junction side for signal readout and the ohmic side for X-ray entrance. Considering the absorption length of 12-keV X-rays suitable for crystallography, a 500-mu m-thick silicon wafer with a high resistivity was used for PD fabrication. It has a guard ring, an n+ edge field shaper, and an antireflection coating (ARC) and is available in four different types based on the metal structure of the junction and ohmic sides. We present here the electrical characteristics of the PDs. The depletion voltage at which the bulk of the PD is fully depleted was determined to be 119.7 +/- 8.2 V from bulk capacitance measurements, and the operation voltage of the PD was set to 200 V. PDs with leakage currents less than 30 nA/cm(2) at the operation voltage were chosen for performance measurements. The signal-to-noise ratio (SNR) with a Sr-90 radioactive source corresponding to the minimum ionizing particle (MIP) and the quantum efficiency (QE) for wavelengths of 300-1000 nm were measured. Beam tests were conducted at the PAL-XFEL using 600-, 900-, and 1200-eV X-rays where the responses to ultrahigh brightness and ultrashort X-ray pulses were checked. The energy resolutions were measured using gamma-ray radioactive sources, Am-241 (59.5 keV), and Ba-133 (31.0 and 81.0 keV). The differences in performance among the PD types are presented herein in terms of the electrical characteristics, SNR, QE, response to X-ray pulses, and energy resolutions. The results of the fabricated PDs were also compared with those of a commercial PD. | Baek, Jongmin; Hwang, Sunmin; Hyun, Hyojung; Jang, Hoyoung; Kim, Jinyong; Kim, Seonghan; Lee, Seungcheol; Park, Hwanbae | Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Pohang Accelerator Lab, XFEL Beamline Div, Pohang 37673, South Korea | Kim, Yong-Tae/HQZ-0240-2023 | 57787573100; 57196317950; 35233487300; 59475359100; 57208867729; 57213778407; 57257924100; 35086680500 | jongmin6301@knu.ac.lcr;hwangsm@postech.ac.kr;hjhyun@postech.ac.kr;h.jang@postech.ac.kr;wlsdyd0710@postech.ac.kr;kimsh80@postech.ac.kr;seungchu19111@knu.ac.kr;sunshine@knu.ac.kr; | IEEE TRANSACTIONS ON NUCLEAR SCIENCE | IEEE T NUCL SCI | 0018-9499 | 1558-1578 | 69 | 8 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;NUCLEAR SCIENCE & TECHNOLOGY | 2022 | 1.8 | 33.8 | 0.18 | 2025-06-25 | 2 | 2 | Energy resolution; fabrication; p-intrinsic-n (PIN) photodiode (PD); Pohang Accelerator Laboratory X-ray Free-Electron Laser (PAL-XFEL); quantum efficiency (QE); signal-to-noise ratio (SNR); X-ray | FREE-ELECTRON LASER; SILICON; HARD; RADIATION; RESPONSES; DESIGN | Energy resolution; fabrication; p-intrinsic-n (PIN) photodiode (PD); Pohang Accelerator Laboratory X-ray Free-Electron Laser (PAL-XFEL); quantum efficiency (QE); signal-to-noise ratio (SNR); X-ray | Cadmium telluride; Capacitance; Electrons; Fabrication; Free electron lasers; Gamma rays; Laser beams; Leakage currents; Photodiodes; Silicon detectors; Silicon wafers; X ray detectors; Commercial photodiodes; Energy resolutions; Measurement by laser beam; Performance; Performance measurements; PIN photodiode; Pohang accelerator laboratory-X-ray free electron laser; X-ray detections; X-ray energies; X-ray free electron lasers; Signal to noise ratio | English | 2022 | 2022-08 | 10.1109/tns.2022.3186481 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Treatment of gouty arthritis is associated with restoring the gut microbiota and promoting the production of short-chain fatty acids | Introduction Although factors initiating the inflammatory response to monosodium urate crystals have been identified, the role of the gut microbiota and their metabolites on gout remains unknown. This study aimed to investigate the changes in both gut microbiota and short-chain fatty acids (SCFAs) according to inflammatory states of gout in the same patients. Methods This study enrolled 20 patients with gout in the acute state who had active joints and were followed up until the recovery state with no active joints. Blood and fecal samples were simultaneously collected within 3 days for each disease state. The stool microbiome was analyzed using 16S rRNA sequencing, and serum SCFAs were measured by gas chromatography-mass spectrometry. Differences in the gut microbiome and serum SCFAs were compared between the acute and recovery states. Results Beta diversity of the microbiome was significantly different between the acute and recovery states in terms of weighted UniFrac distance. In the recovery state, Prevotellaceae (p = 0.006) and the genus Prevotella (p = 0.009) were significantly enriched, whereas Enterobacteriaceae (p = 0.019) and its derivative genus Shigella (p = 0.023) were significantly decreased compared to the acute state. Similarly, the levels of acetate were dramatically increased in the recovery state compared to the acute state (p < 0.010). The levels of propionate and butyrate tended to increase but without statistical significance. Conclusion Substantial alterations of bacterial composition with the promotion of SCFA formation (especially acetate) were found after treatment in patients with gouty arthritis. | Park, Han-Ki; Lee, Sang Jin | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Seoul Natl Univ, Dept Mol Med & Biopharmaceut Sci, Grad Sch Convergence Sci & Technol, Seoul, South Korea; Seoul Natl Univ, Coll Med, Med Res Inst, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med Rheumatol, 130 Dongdeok Ro, Daegu 41944, South Korea | Park, Han-Ki/AAY-3102-2020 | 57218664064; 57192516055 | dream1331@knu.ac.kr; | ARTHRITIS RESEARCH & THERAPY | ARTHRITIS RES THER | 1478-6354 | 1478-6362 | 24 | 1 | SCIE | RHEUMATOLOGY | 2022 | 4.9 | 33.8 | 2.05 | 2025-06-25 | 23 | 21 | Gouty arthritis; Gut microbiota; Short-chain fatty acids | INTERLEUKIN-1-BETA; INFLAMMATION; SIGNATURE; LINKING | Gouty arthritis; Gut microbiota; Short-chain fatty acids | Arthritis, Gouty; Fatty Acids, Volatile; Feces; Gastrointestinal Microbiome; Humans; RNA, Ribosomal, 16S; butyric acid; short chain fatty acid; RNA 16S; volatile fatty acid; acute disease; adult; Article; blood sampling; clinical article; controlled study; Enterobacteriaceae; feces culture; female; follow up; genus; gout; human; inflammation; intestine flora; male; microbiome; middle aged; nonhuman; Prevotellaceae; species composition; species diversity; chemistry; feces; genetics; gout; metabolism; microbiology | English | 2022 | 2022-02-19 | 10.1186/s13075-022-02742-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | A Collagen Hydrolysate Containing Tripeptides Ameliorates Sarcopenia in Middle-Aged Mice | Collagen peptide (CP) and collagen tripeptide (CTP) are supplementary health foods that exhibit several biological effects. However, the effects of collagen on age-associated sarcopenia and its underlying mechanisms are unclear. C57BL/6J mice (n = 24, 12 months old) were divided into three dietary groups and administered AIN93G (aging control, AC; JA BIO, Suwon, Korea), AIN93G plus 0.2% CP, and AING93G plus 0.2% CTP supplement for 12 weeks. The results indicated that the CP and CTP supplements significantly increased the weight of the quadriceps tibialis anterior and gastrocnemius muscles and reduced body fat. A morphological analysis revealed that the spaces within the muscle cells were tight with attenuated fibrosis following CP and CTP supplementation. Immunohistochemistry was applied and a Western blot analysis was performed to determine the underlying mechanisms. The CTP supplement increased the expression of IGF-1, PI3K/AKT, and mTOR, whereas the CP supplement increased the expression of IGF-1 and AMPK in the gastrocnemius of aging mice. CP and CTP ameliorate age-associated sarcopenia through different mechanisms. | Kim, Ji-Eun; Kwon, Eun-Young; Han, Youngji | Kyungpook Natl Univ, Dept Food Sci & Nutr, 1370 San Kyuk Dong Puk Ku, Daegu 41566, South Korea; Kyungpook Natl Univ, Ctr Food & Nutr Genom Res, 1370 San Kyuk Dong Puk Ku, Daegu 41566, South Korea; Kyungpook Natl Univ, Ctr Beautiful Aging, 1370 San Kyuk Dong Puk Ku, Daegu 41566, South Korea | 57339905700; 15765422500; 57206914262 | ths01035@naver.com;eykwon@knu.ac.kr;youngjihan@knu.ac.kr; | MOLECULES | MOLECULES | 1420-3049 | 27 | 9 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 4.6 | 33.9 | 1.25 | 2025-06-25 | 12 | 13 | collagen hydrolysate; collagen tripeptide; aging; sarcopenia; muscle loss | MUSCLE FAT INFILTRATION; BODY-COMPOSITION; PEPTIDE SUPPLEMENTATION; CARDIOVASCULAR-DISEASE; OBESITY; SKIN; MYOSTATIN; ATROGIN-1; STRENGTH; GLUCOSE | Aging; Collagen hydrolysate; Collagen tripeptide; Muscle loss; Sarcopenia | Aging; Animals; Collagen; Cytidine Triphosphate; Insulin-Like Growth Factor I; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Peptides; Phosphatidylinositol 3-Kinases; Sarcopenia; collagen; cytidine triphosphate; peptide; phosphatidylinositol 3 kinase; somatomedin C; aging; animal; C57BL mouse; metabolism; mouse; sarcopenia; skeletal muscle | English | 2022 | 2022-05 | 10.3390/molecules27092718 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Anti-Inflammatory, Antioxidative, and Nitric Oxide-Scavenging Activities of a Quercetin Nanosuspension with Polyethylene Glycol in LPS-Induced RAW 264.7 Macrophages | Quercetin (Qu) is a dietary antioxidant and a member of flavonoids in the plant polyphenol family. Qu has a high ability to scavenge reactive oxygen species (ROS) and reactive nitrogen species (RNS) molecules; hence, exhibiting beneficial effects in preventing obesity, diabetes, cancer, cardiovascular diseases, and inflammation. However, quercetin has low bioavailability due to poor water solubility, low absorption, and rapid excretion from the body. To address these issues, the usage of Qu nanosuspensions can improve physical stability, solubility, and pharmacokinetics. Therefore, we developed a Qu and polyethylene glycol nanosuspension (Qu-PEG NS) and confirmed its interaction by Fourier transform infrared analysis. Qu-PEG NS did not show cytotoxicity to HaCaT and RAW 264.7 cells. Furthermore, Qu-PEG NS effectively reduced the nitrogen oxide (NO) production in lipopolysaccharide (LPS)-induced inflammatory RAW 264.7 cells. Additionally, Qu-PEG NS effectively lowered the levels of COX-2, NF-kappa B p65, and IL-1 beta in the LPS-induced inflammatory RAW 264.7 cells. Specifically, Qu-PEG NS exhibited anti-inflammatory properties by scavenging the ROS and RNS and mediated the inhibition of NF-kappa B signaling pathways. In addition, Qu-PEG NS had a high antioxidant effect and antibacterial activity against Escherichia coli and Bacillus cereus. Therefore, the developed novel nanosuspension showed comparable antioxidant, anti-inflammatory, and antibacterial functions and may also improve solubility and physical stability compared to raw quercetin. | Kang, Sang Gu; Lee, Gi Baek; Vinayagam, Ramachandran; Do, Geum Sook; Oh, Se Yong; Yang, Su Jin; Kwon, Jun Bum; Singh, Mahendra | Yeungnam Univ, Inst Biotechnol Life & Appl Sci, Dept Biotechnol, Gyongsan 38541, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Dept Biol, Daegu 41566, South Korea; Nova M Healthcare Co Ltd, 16-53,Jisiksaneop 4-Ro, Gyongsan 38408, South Korea | ; Vinayagam, Ramachandran/AAX-9725-2020 | 55855825800; 57959426000; 57197140894; 57201113384; 57959426100; 59642095000; 57959648300; 57908535400 | kangsg@ynu.ac.kr;m.singh2685@gmail.com; | MOLECULES | MOLECULES | 1420-3049 | 27 | 21 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 4.6 | 33.9 | 2.51 | 2025-06-25 | 26 | 26 | quercetin; nanosuspension; antioxidant properties; flavonoids; LPS-induced inflammation; NO-scavenging activity | IN-VITRO; ALZHEIMERS-DISEASE; INFLAMMATION; INHIBITION; SOLUBILITY; EXTRACT; ENHANCEMENT; DISPERSIONS; DERIVATIVES; MECHANISMS | antioxidant properties; flavonoids; LPS-induced inflammation; nanosuspension; NO-scavenging activity; quercetin | Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antioxidants; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Nitric Oxide; Polyethylene Glycols; Quercetin; RAW 264.7 Cells; Reactive Oxygen Species; antiinfective agent; antiinflammatory agent; antioxidant; immunoglobulin enhancer binding protein; lipopolysaccharide; macrogol; nitric oxide; quercetin; reactive oxygen metabolite; animal; macrophage; metabolism; mouse; RAW 264.7 cell line | English | 2022 | 2022-11 | 10.3390/molecules27217432 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Biological Potentials and Phytochemical Constituents of Raw and Roasted Nigella arvensis and Nigella sativa | Nigella species are widely used to cure various ailments. Their health benefits, particularly from the seed oils, could be attributed to the presence of a variety of bioactive components. Roasting is a critical process that has historically been used to facilitate oil extraction and enhance flavor; it may also alter the chemical composition and biological properties of the Nigella seed. The aim of this study was to investigate the effect of the roasting process on the composition of the bioactive components and the biological activities of Nigella arvensis and Nigella sativa seed extracts. Our preliminary study showed that seeds roasted at 50 degrees C exhibited potent antimicrobial activities; therefore, this temperature was selected for roasting Nigella seeds. For extraction, raw and roasted seed samples were macerated in methanol. The antimicrobial activities against Streptococcus agalactiae, Streptococcus epidermidis, Streptococcus pyogenes, Candida albicans, Escherichia coli, Enterobacter aerogenes, Klebsiella pneumoniae, and Klebsiella oxytoca were determined by measuring the diameter of the zone of inhibition. The cell viability of extracts was tested in a colon carcinoma cell line, HCT-116, by using a microculture tetrazolium technique (MTT) assay. Amino acids were extracted and quantified using an automatic amino acid analyzer. Then, gas chromatography-mass spectrometry (GC-MS) analysis was performed to identify the chemical constituents and fatty acids. As a result, the extracts of raw and roasted seeds in both Nigella species showed strong inhibition against Klebsiella oxytoca, and the raw seed extract of N. arvensis demonstrated moderate inhibition against S. pyogenes. The findings of the MTT assay indicated that all the extracts significantly decreased cancer cell viability. Moreover, N. sativa species possessed higher contents of the measured amino acids, except tyrosine, cystine, and methionine. The GC-MS analysis of extracts showed the presence of 22 and 13 compounds in raw and roasted N. arvensis, respectively, and 9 and 11 compounds in raw and roasted N. sativa, respectively. However, heat treatment decreased the detectable components to 13 compounds in roasted N. arvensis and increased them in roasted N. sativa. These findings indicate that N. arvensis and N. sativa could be potential sources of anticancer and antimicrobials, where the bioactive compounds play a pivotal role as functional components. | Alshwyeh, Hussah Abdullah; Aldosary, Sahar Khamees; Ilowefah, Muna Abdulsalam; Shahzad, Raheem; Shehzad, Adeeb; Bilal, Saqib; Lee, In-Jung; Al Mater, Jannah Ahmed; Al-Shakhoari, Fatima Najf; Alqahtani, Waad Abdulrahman; Kamal, Nurkhalida; Mediani, Ahmed | Imam Abdulrahman Bin Faisal Univ, Dept Biol, Coll Sci, Dammam 314411982, Saudi Arabia; Sabha Univ, Fac Engn & Technol, Dept Food Technol, Sabha, Libya; Univ Haripur, Dept Hort, Haripur 22620, Khyber Pakhtunk, Pakistan; Natl Univ Sci & Technol, Sch Mech & Mfg Engn, Dept Biomed Sci, Bolan Rd,H-12, Islamabad 44000, Pakistan; Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa 616, Oman; Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea; Univ Kebangsaan Malaysia, Inst Syst Biol, Bangi 43600, Selangor, Malaysia | ; Shahzad, Raheem/AAG-8370-2019; Mediani, Ahmed/AAP-4700-2020; Lee, In-Jung/GLS-0432-2022; Kamal, Nurkhalida/AAT-5239-2020; Aldosary, Sahar/AAD-1243-2020; Shehzad, Adeeb/HHN-4847-2022 | 57216437664; 57094187500; 55796412400; 56454250900; 36162526700; 57031617400; 16425830900; 57415787900; 57416176300; 57415664000; 57104858100; 55375944000 | medianiahmed47@gmail.com;skdosary@iau.edu.sa;stardream-17@hotmail.com;shakhoarifn@hotmail.com;waadalqahtani97@gmail.com;mona.milad2005@gmail.com;raheem.shahzad@uoh.edu.pk;adeeb.shahzad@gmail.com;saqib043@yahoo.com;ijlee@knu.ac.kr;nurkhalida.kamal@ukm.edu.my;haalshuyeh@iau.edu.sa; | MOLECULES | MOLECULES | 1420-3049 | 27 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 4.6 | 33.9 | 1.16 | 2025-06-25 | 10 | 12 | Nigella arvensis; Nigella sativa; antimicrobial activity; MTT; methanol extract; GC-MS | L. | Antimicrobial activity; GC–MS; Methanol extract; MTT; Nigella arvensis; Nigella sativa | Amino Acids; Anti-Infective Agents; Bacteria; Cell Survival; Cooking; Fatty Acids; Food Handling; Gas Chromatography-Mass Spectrometry; Nigella; Phytochemicals; Plant Extracts; Seeds; amino acid; antiinfective agent; fatty acid; phytochemical; plant extract; bacterium; cell survival; chemistry; cooking; drug effect; food handling; isolation and purification; mass fragmentography; Nigella; plant seed; procedures | English | 2022 | 2022-01 | 10.3390/molecules27020550 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Deep Learning and Structure-Based Virtual Screening for Drug Discovery against NEK7: A Novel Target for the Treatment of Cancer | NIMA-related kinase7 (NEK7) plays a multifunctional role in cell division and NLRP3 inflammasone activation. A typical expression or any mutation in the genetic makeup of NEK7 leads to the development of cancer malignancies and fatal inflammatory disease, i.e., breast cancer, non-small cell lung cancer, gout, rheumatoid arthritis, and liver cirrhosis. Therefore, NEK7 is a promising target for drug development against various cancer malignancies. The combination of drug repurposing and structure-based virtual screening of large libraries of compounds has dramatically improved the development of anticancer drugs. The current study focused on the virtual screening of 1200 benzene sulphonamide derivatives retrieved from the PubChem database by selecting and docking validation of the crystal structure of NEK7 protein (PDB ID: 2WQN). The compounds library was subjected to virtual screening using Auto Dock Vina. The binding energies of screened compounds were compared to standard Dabrafenib. In particular, compound 762 exhibited excellent binding energy of -42.67 kJ/mol, better than Dabrafenib (-33.89 kJ/mol). Selected drug candidates showed a reactive profile that was comparable to standard Dabrafenib. To characterize the stability of protein-ligand complexes, molecular dynamic simulations were performed, providing insight into the molecular interactions. The NEK7-Dabrafenib complex showed stability throughout the simulated trajectory. In addition, binding affinities, pIC50, and ADMET profiles of drug candidates were predicted using deep learning models. Deep learning models predicted the binding affinity of compound 762 best among all derivatives, which supports the findings of virtual screening. These findings suggest that top hits can serve as potential inhibitors of NEK7. Moreover, it is recommended to explore the inhibitory potential of identified hits compounds through in-vitro and in-vivo approaches. | Aziz, Mubashir; Ejaz, Syeda Abida; Zargar, Seema; Akhtar, Naveed; Aborode, Abdullahi Tunde; Wani, Tanveer A.; Batiha, Gaber El-Saber; Siddique, Farhan; Alqarni, Mohammed; Akintola, Ashraf Akintayo | Islamia Univ Bahawalpur, Fac Pharm, Dept Pharmaceut Chem, Bahawalpur 63100, Pakistan; King Saud Univ, Coll Sci, Dept Biochem, POB 22452, Riyadh 11451, Saudi Arabia; Islamia Univ Bahawalpur, Fac Pharm, Dept Pharmaceut, Bahawalpur 63100, Pakistan; Mississippi State Univ, Dept Chem, Starkville, MS 39759 USA; King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, POB 2457, Riyadh 11451, Saudi Arabia; Damanhour Univ, Fac Vet Med, Dept Pharmacol & Therapeut, Damanhour 22511, Albeheira, Egypt; Linkoping Univ, Dept Sci & Technol, Lab Organ Elect, SE-60174 Norrkoping, Sweden; Royal Inst Med Sci RIMS, Dept Pharm, Multan 60000, Pakistan; Taif Univ, Coll Pharm, Dept Pharmaceut Chem, POB 11099, Taif 21944, Saudi Arabia; Kyungpook Natl Univ, Dept Biomed Convergence Sci & Technol, Daegu 41566, South Korea | Aziz, Mubashir/JCO-8359-2023; Zargar, Seema/AAW-9151-2021; Ejaz, Syeda Abida/GLR-2543-2022; Abdullahi, Aborode/AAL-6793-2021; Alqarni, Mohammed Z./ISA-1854-2023; Siddique, Farhan/AFJ-2815-2022; Akintola, Ashraf/KZU-7081-2024; Wani, Tanveer/AAX-3859-2021 | 57385052700; 55521133400; 55459461900; 15055469300; 57916532700; 59678934500; 57200946172; 57203261588; 57221053161; 57218618629 | mubashirali035@gmail.com;abida.ejaz@iub.edu.pk;szargar@ksu.edu.pk;naveed.akhtar@iub.edu.pk;abdullahiaborodet@gmail.com;twani@ksu.edu.sa;gaberbatiha@gmail.com;drfarhansiddique@gmail.com;m.alqarni@tu.edu.sa;ashraf.akintola@gmail.com; | MOLECULES | MOLECULES | 1420-3049 | 27 | 13 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 4.6 | 33.9 | 4.05 | 2025-06-25 | 38 | 42 | NEK7; virtual screening; DFTs; deep learning; molecular dynamics; drug design; drug repurposing; structural-based; cancer | MOLECULAR DOCKING; THERAPY TARGET; DYNAMICS; INHIBITORS; IDENTIFICATION; SULFONAMIDES; ANTICANCER; DESIGN; TRIMETHOPRIM | cancer; deep learning; DFTs; drug design; drug repurposing; molecular dynamics; NEK7; structural-based; virtual screening | Carcinoma, Non-Small-Cell Lung; Deep Learning; Drug Discovery; Early Detection of Cancer; Humans; Lung Neoplasms; Molecular Docking Simulation; Molecular Dynamics Simulation; NIMA-Related Kinases; NEK7 protein, human; NIMA related kinase; drug development; early cancer diagnosis; human; lung tumor; molecular docking; molecular dynamics; non small cell lung cancer | English | 2022 | 2022-07 | 10.3390/molecules27134098 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Evaluation of Toxicity and Efficacy of Inotodiol as an Anti-Inflammatory Agent Using Animal Model | Chaga mushroom (Inonotus obliquus) comprises polyphenolic compounds, triterpenoids, polysaccharides, and sterols. Among the triterpenoid components, inotodiol has been broadly examined because of its various biological activities. The purpose of this study is to examine inotodiol from a safety point of view and to present the potential possibilities of inotodiol for medical usage. From chaga mushroom extract, crude inotodiol (INO20) and pure inotodiol (INO95) were produced. Mice were treated with either INO20 or INO95 once daily using oral administration for repeated dose toxicity evaluation. Serum biochemistry parameters were analyzed, and the level of pro-inflammatory cytokines in the serum was quantified. In parallel, the effect of inotodiol on food allergic symptoms was investigated. Repeated administration of inotodiol did not show any mortality or abnormalities in organs. In food allergy studies, the symptoms of diarrhea were ameliorated by administration with INO95 and INO20. Furthermore, the level of MCPT-1 decreased by treatment with inotodiol. In this study, we demonstrated for the first time that inotodiol does not cause any detrimental effect by showing anti-allergic activities in vivo by inhibiting mast cell function. Our data highlight the potential to use inotodiol as an immune modulator for diseases related to inflammation. | Thi Minh Nguyet Nguyen; Ban, So-Young; Park, Kyu-Been; Lee, Chang-Kyu; Lee, Seoung-Woo; Lee, Young-Jin; Baek, Su-Min; Park, Jin-Kyu; My Tuyen Thi Nguyen; Kim, Jaehan; Park, Jihyun; Park, Jong-Tae | CARBOEXPERT Inc, Daejeon 34134, Peoples R China; Chungnam Natl Univ, Dept Food Sci & Technol, Daejeon 34134, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Pathol, Daegu 41566, South Korea; Chungnam Natl Univ, Dept Food & Nutr, Daejeon 34134, South Korea | 59938571400; 57436211000; 57200322471; 57327443600; 57218827581; 57491815500; 57207938426; 35213723500; 57208529478; 7601374503; 57829264300; 57033057200 | nguyet@carboexpert.com;syban@carboexpert.com;kbpark@carboexpert.com;cklee@carboexpert.com;pyrk2000@gmail.com;bnm3448123@naver.com;suminbaek@naver.com;jinkyu820@knu.ac.kr;mytuyen108@gmail.com;jaykim@cnu.ac.kr;jane.park7434@gmail.com;jtpark@cnu.ac.kr; | MOLECULES | MOLECULES | 1420-3049 | 27 | 15 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 4.6 | 33.9 | 1.54 | 2025-06-25 | 16 | 16 | inotodiol; toxicity; inflammation; allergy; mast cell | INONOTUS-OBLIQUUS; FOOD ALLERGY; EXTRACT; MUSHROOM; INFLAMMATION; CELLS | allergy; inflammation; inotodiol; mast cell; toxicity | Animals; Anti-Inflammatory Agents; Disease Models, Animal; Inonotus; Lanosterol; Mice; Triterpenes; antiinflammatory agent; inotodiol; lanosterol; triterpene; animal; disease model; Inonotus; mouse | English | 2022 | 2022-08 | 10.3390/molecules27154704 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Finite element model updating of composite with adhesive jointed structure under built-up internal stress | Highly complex engineering structures such as the body-in-white of a car consist of hundreds of different parts that are assembled using various types of joints such as welded and adhesive joints. The finite element method has been used extensively in various engineering fields to predict and analyze the dynamic behavior of assembled structures. However, despite the use of well-characterized individual subcomponent models, the predicted results frequently differ from measured results. This is believed to be because of the invalid assumptions of the joint model such as the material properties and other uncertainties associated with the assembly. This study investigated the use of a model updating method (MSC Nastran SOL 200) to identify the invalid assumptions and uncertainties in adhesive jointed composite structures and to minimize the difference between predicted and measured results. Results revealed that the stresses built-up in a structure during the assembly process are permanently retained in the structure after the adhesive is completely cured and that they cause a local stress stiffening effect, which is believed to affect the resonance frequencies of the structure. Introducing the effect of the stresses as an updating parameter in the model updating process increases the prediction accuracy. | Ahmad Basri, Ahmad Burhani; Chae, Dong Wook; Lee, Hyeongill | Kyungpook Natl Univ, Sch Automot Engn, 2559 Gyeongsang Daero, Sangju 37224, Gyeongsangbuk D, South Korea; Kyungpook Natl Univ, Dept Text Engn, Sangju, South Korea | Ahmad Basri, Ahmad Burhani/AAX-5302-2021 | 57217176021; 7006246752; 8261483800 | hilee@knu.ac.kr; | JOURNAL OF VIBRATION AND CONTROL | J VIB CONTROL | 1077-5463 | 1741-2986 | 28 | 11-12 | SCIE | ACOUSTICS;ENGINEERING, MECHANICAL;MECHANICS | 2022 | 2.8 | 33.9 | 0.42 | 2025-06-25 | 3 | 5 | Model updating; axial stress; finite element method; adhesive joint; modal analysis; composite | SELECTION; DYNAMICS | adhesive joint; axial stress; composite; finite element method; modal analysis; Model updating | Adhesive joints; Adhesives; Finite element method; Sols; Assembled structures; Assembly process; Complex engineering; Dynamic behaviors; Engineering fields; Finite-element model updating; Prediction accuracy; Resonance frequencies; Composite structures | English | 2022 | 2022-06 | 10.1177/1077546321993580 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Hepatoprotective Potential of Malaysian Medicinal Plants: A Review on Phytochemicals, Oxidative Stress, and Antioxidant Mechanisms | Hepatotoxicity is a major global public health concern. Despite advances in modern medicine, the demerits of chemically prepared drugs outweigh their merits. In addition, the treatment of liver diseases based on modern medical principles has been found to produce several undesired side effects. Therefore, the exploration of medicinal plants has gained worldwide attention for treating various diseases, including liver diseases, owing to their potential efficacy and cost effectiveness.Several plants, including Andrographis paniculata, Bauhinia purpurea, Commelina nudiflora, Dillenia suffruticosa, Elaeis guineensis, Lygodium microphyllum, and Nephrolepis biserrata, have been reported with hepatoprotection. Moreover, these plants have been shown to play a vital role in ameliorating cellular damage because they contain several phytochemicals, including alkaloids, saponins, flavonoids, tannins, terpenoids, steroids, polyphenols, and diterpenoid lactones. The following antioxidant, anti-inflammatory, immunomodulatory, and hepatoprotective compounds have been found in these plants: andrographolide, rosmarinic acid, phenol, eugenol, 9,12-octadecadienoic, n-hexadecanoic acid, dihydroxy dimethoxy flavone, sitosterol, demethoxycurcumin, quercetin, linoleic acid, stigmasterol, kojic acid, indole-2-one, alpha-terpinol, linalool, kaempferol, catechin, ellagic acid, and oleanolic acid. This paper aimed to provide an in-depth review of in vivo studies on Malaysian medicinal plants possessing hepatoprotective properties, phytochemical ingredients, and antioxidant mechanisms, with an emphasis on the species proven particularly useful for treating hepatic disorders. | Venmathi Maran, Balu Alagar; Iqbal, Mohammad; Gangadaran, Prakash; Ahn, Byeong-Cheol; Rao, Pasupuleti Visweswara; Shah, Muhammad Dawood | Univ Malaysia Sabah, Borneo Marine Res Inst, Kota Kinabalu 88400, Sabah, Malaysia; Univ Malaysia Sabah, Biotechnol Res Inst, Kota Kinabalu 88400, Sabah, Malaysia; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Univ Malaysia Sabah, Fac Med & Hlth Sci, Dept Biomed Sci & Therapeut, Kota Kinabalu 88400, Sabah, Malaysia; Abdurrab Univ, Fac Med & Hlth Sci, Dept Biochem, Pekanbaru 28292, Riau, Indonesia; Reva Univ, Ctr Int Collaborat & Res, Rukmini Knowledge Pk, Bangalore 560064, Karnataka, India | Gangadaran, Prakash/AAV-3102-2021; Venmathi Maran, Balu Alagar/G-5163-2014; PASUPULETI, VISWESWARA/A-7429-2013; PASUPULETI, VISWESWARA RAO/A-7429-2013 | 58789989400; 57201935041; 54393130400; 7202791511; 55904825600; 36444264400 | bavmaran@ums.edu.my;miqbal@ums.edu.my;prakashg@knu.ac.kr;abc2000@knu.ac.kr;pvrao@ums.edu.my;dawoodshah@ums.edu.my; | MOLECULES | MOLECULES | 1420-3049 | 27 | 5 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 4.6 | 33.9 | 1.52 | 2025-06-25 | 31 | 42 | medicinal plants; oxidative stress; phytochemicals; hepatoprotective; carbon tetrachloride | INDUCED LIVER-INJURY; CARBON-TETRACHLORIDE; ANDROGRAPHIS-PANICULATA; HEPATIC DAMAGE; NATURAL ANTIOXIDANTS; INFLAMMATORY MARKERS; CYMBOPOGON-CITRATUS; METHANOL EXTRACT; ESSENTIAL OIL; LEAF EXTRACT | Carbon tetrachloride; Hepatoprotective; Medicinal plants; Oxidative stress; Phytochemicals | Antioxidants; Oxidative Stress; Phytochemicals; Plant Extracts; Plants, Medicinal; antioxidant; phytochemical; plant extract; chemistry; medicinal plant; metabolism; oxidative stress | English | 2022 | 2022-03 | 10.3390/molecules27051533 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Identification of New Non-BBB Permeable Tryptophan Hydroxylase Inhibitors for Treating Obesity and Fatty Liver Disease | Serotonin (5-hydroxytryptophan) is a hormone that regulates emotions in the central nervous system. However, serotonin in the peripheral system is associated with obesity and fatty liver disease. Because serotonin cannot cross the blood-brain barrier (BBB), we focused on identifying new tryptophan hydroxylase type I (TPH1) inhibitors that act only in peripheral tissues for treating obesity and fatty liver disease without affecting the central nervous system. Structural optimization inspired by para-chlorophenylalanine (pCPA) resulted in the identification of a series of oxyphenylalanine and heterocyclic phenylalanine derivatives as TPH1 inhibitors. Among these compounds, compound 18i with an IC50 value of 37 nM was the most active in vitro. Additionally, compound 18i showed good liver microsomal stability and did not significantly inhibit CYP and Herg. Furthermore, this TPH1 inhibitor was able to actively interact with the peripheral system without penetrating the BBB. Compound 18i and its prodrug reduced body weight gain in mammals and decreased in vivo fat accumulation. | Pagire, Suvarna H.; Pagire, Haushabhau S.; Park, Kun-Young; Bae, Eun Jung; Kim, Kwang-eun; Kim, Minhee; Yoon, Jihyeon; Parameswaran, Saravanan; Choi, Jun-Ho; Park, Sungmi; Jeon, Jae-Han; Song, Jin Sook; Bae, Myung Ae; Lee, In-Kyu; Kim, Hail; Suh, Jae Myoung; Ahn, Jin Hee | Gwangju Inst Sci & Technol, Dept Chem, Gwangju 61005, South Korea; JD Biosci, 208 Beon Gil, Gwangju 61005, South Korea; Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Daejeon 34141, South Korea; Korea Adv Inst Sci & Technol, Biomed Sci & Engn Interdisciplinary Program, Daejeon 34141, South Korea; JSS Acad Higher Educ & Res JSS AHER, Sch Life Sci, Dept Biotechnol & Bioinformat, Mysuru 570015, India; Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet, Daegu 41404, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu 41404, South Korea; Korea Res Inst Chem Technol, Bio & Drug Discovery Div, Daejeon 34141, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea | ; Parameswaran, Saravanan/F-3189-2011; Suh, Jae/B-3268-2015; Kim, Hail/C-5608-2018; Ahn, Jin/C-6122-2019; Suh, Jae Myoung/B-3268-2015; Lee, In-Kyu/AAR-6374-2021; P, Saravanan/F-3189-2011 | 56716279400; 55599893000; 57214823513; 57200112023; 58390060300; 57723465700; 57216544129; 29167545800; 56395639200; 56252420000; 36910340400; 57211755720; 7005711682; 36071537600; 7410126420; 36799636000; 56714432600 | shpagire@gist.ac.kr;hspagire@gist.ac.kr;pky1171@kaist.ac.kr;helloimej@gist.ac.kr;werd2000@snu.ac.kr;kmh0724@gist.ac.kr;yjh1@jdbiosci.com;dr.p.saravanan.bi@gmail.com;junhochoi@gist.ac.kr;smpark93@gmail.com;ggoloo@hanmail.net;jssong@krict.re.kr;mbae@krict.re.kr;leei@knu.ac.kr;hailkim@kaist.edu;jmsuh@kaist.ac.kr;jhahn@gist.ac.kr; | MOLECULES | MOLECULES | 1420-3049 | 27 | 11 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 4.6 | 33.9 | 0.77 | 2025-06-25 | 8 | 8 | tryptophan hydroxylase inhibitor; obesity; fatty liver; treatment | PERIPHERAL SEROTONIN; BRAIN; PREDICTION | fatty liver; obesity; treatment; tryptophan hydroxylase inhibitor | Animals; Blood-Brain Barrier; Liver Diseases; Mammals; Obesity; Serotonin; Tryptophan Hydroxylase; serotonin; tryptophan hydroxylase; animal; blood brain barrier; liver disease; mammal; metabolism; obesity | English | 2022 | 2022-06 | 10.3390/molecules27113417 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Identification of p-Coumaric Acid and Ethyl p-Coumarate as the Main Phenolic Components of Hemp (Cannabis sativa L.) Roots | Hemp (Cannabis sativa L.) contains a variety of secondary metabolites, including cannabinoids, such as psychoactive (-)-trans-Delta(9)-tetrahydrocannabinol. The present study was conducted to identify the major phenolic components contained in hemp root, which has been relatively under-researched compared to other parts of hemp. The aqueous ethanol extract of hemp roots was fractionated into methylene chloride (MC), ethyl acetate (EA), and water (WT) fractions, and high-performance liquid chromatography with photodiode array detection (HPLC-DAD) analysis was performed. The main ultraviolet (UV)-absorbing phenolic compound contained in the EA fraction was identified as p-coumaric acid by comparing the retention time and UV absorption spectrum with a standard. Silica gel column chromatography was performed to isolate a hydrophobic derivative of p-coumaric acid contained in the MC fraction. Nuclear magnetic resonance (NMR) analysis identified the isolated compound as ethyl p-coumarate. For comparative purposes, ethyl p-coumarate was also chemically synthesized by the esterification reaction of p-coumaric acid. The content of p-coumaric acid and ethyl p-coumarate in the total extract of hemp root was estimated to be 2.61 mg g(-1) and 6.47 mg g(-1), respectively, by HPLC-DAD analysis. These values correspond to 84 mg Kg(-1) dry root and 216 mg Kg(-1) dry root, respectively. In conclusion, this study identified p-coumaric acid and ethyl p-coumarate as the main phenolic compounds contained in the hemp roots. | Oh, Chang Min; Choi, Joon Yong; Bae, In Ah; Kim, Hong Taek; Hong, Seong Su; Noah, Jay Kyun; Boo, Yong Chool | Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Grad Sch, BK21 Plus KNU Biomed Convergence Program, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Gyeonggido Business & Sci Accelerator GBSA, Bioctr, 147 Gwanggyo Ro, Suwon 16229, South Korea; Jayhempkorea, 211-13 Hyoja Ro, Sangju Si 37142, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, 680 Gukchaebosang Ro, Daegu 41944, South Korea | 57644549900; 57576409100; 57575559300; 57680052500; 35074089600; 57678515700; 6602899130 | ckdals9669@naver.com;halo134679@naver.com;sksnadlv@naver.com;aopp654@naver.com;bestgene@gbsa.or.kr;jayk.noah@jayhempkorea.com;ycboo@knu.ac.kr; | MOLECULES | MOLECULES | 1420-3049 | 27 | 9 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 4.6 | 33.9 | 0.96 | 2025-06-25 | 10 | 10 | hemp root; Cannabis sativa; p-coumaric acid; ethyl p-coumarate; phenolic compounds | ANTIOXIDANT ACTIVITY; INFLORESCENCES; KERATINOCYTES; MELANOGENESIS; CONSTITUENT; LEAVES | Cannabis sativa; ethyl p-coumarate; hemp root; p-coumaric acid; phenolic compounds | Cannabinoids; Cannabis; Chromatography, High Pressure Liquid; Coumaric Acids; Phenols; Plant Extracts; cannabinoid; cannabis; coumaric acid; p-coumaric acid; phenol derivative; plant extract; chemistry; high performance liquid chromatography; procedures | English | 2022 | 2022-05 | 10.3390/molecules27092781 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | In Vitro and In Vivo Protective Effects of Lentil (Lens culinaris) Extract against Oxidative Stress-Induced Hepatotoxicity | Excessive oxidative stress plays a role in hepatotoxicity and the pathogenesis of hepatic diseases. In our previous study, the phenolic extract of beluga lentil (BLE) showed the most potent in vitro antioxidant activity among extracts of four common varieties of lentils; thus, we hypothesized that BLE might protect liver cells against oxidative stress-induced cytotoxicity. BLE was evaluated for its protective effects against oxidative stress-induced hepatotoxicity in AML12 mouse hepatocytes and BALB/c mice. H2O2 treatment caused a marked decrease in cell viability; however, pretreatment with BLE (25-100 mu g/mL) for 24 h significantly preserved the viability of H2O2-treated cells up to about 50% at 100 mu g/mL. As expected, BLE dramatically reduced intracellular reactive oxygen species (ROS) levels in a dose-dependent manner in H2O2-treated cells. Further mechanistic studies demonstrated that BLE reduced cellular ROS levels, partly by increasing expression of antioxidant genes. Furthermore, pretreatment with BLE (400 mg/kg) for 2 weeks significantly reduced serum levels of alanine transaminase and triglyceride by about 49% and 40%, respectively, and increased the expression and activity of glutathione peroxidase in CCl4-treated BALB/c mice. These results suggest that BLE protects liver cells against oxidative stress, partly by inducing cellular antioxidant system; thus, it represents a potential source of nutraceuticals with hepatoprotective effects. | Jung, Yeon-Seop; Lee, So-Hee; Chun, So Young; Kim, Dae Hwan; Jang, Byung Ik; Han, Man-Hoon; Lee, Syng-Ook | Keimyung Univ, Dept Food Sci & Technol, Daegu 42601, South Korea; Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, Daegu 41061, South Korea; Kyungpook Natl Univ Hosp, Biomed Res Inst, Daegu 41404, South Korea; Yeungnam Univ Med Ctr, Dept Lab Anim Res Support Team, Daegu 42415, South Korea; Yeungnam Univ, Dept Internal Med, Coll Med, Daegu 42415, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu 41404, South Korea | ; Lee, Jae-Sung/A-5236-2015; Kim, Jihyun/F-6940-2013 | 55363749400; 57196076317; 8688166900; 55897992900; 22953491400; 57194067936; 12796984400 | jys86170@dgmif.re.kr;jy16162727@naver.co;soyachun99@naver.com;ikorando5@hanmail.net;jbi@med.yu.ac.kr;one-many@hanmail.net;synglee@kmu.ac.kr; | MOLECULES | MOLECULES | 1420-3049 | 27 | 1 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2022 | 4.6 | 33.9 | 1.06 | 2025-06-25 | 11 | 11 | lentil; hepatoprotective effect; oxidative stress; Nrf2 | ANTIOXIDANT | Hepatoprotective effect; Lentil; Nrf2; Oxidative stress | Animals; Antioxidants; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hepatocytes; Hydrogen Peroxide; Lens Plant; Liver; Mice; Oxidative Stress; Plant Extracts; Protective Agents; Reactive Oxygen Species; antioxidant; hydrogen peroxide; plant extract; protective agent; reactive oxygen metabolite; animal; cell line; cell survival; chemistry; disease model; drug effect; lentil; liver; liver cell; metabolism; mouse; oxidative stress; pathology; toxic hepatitis | English | 2022 | 2022-01 | 10.3390/molecules27010059 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Indole propionic acid induced Ca²⁺-dependent apoptosis in Candida albicans | Indole propionic acid (IPA) which majorly influences the modulation of cellular respiration is a metabolite generated by gut microbiota. The antimicrobial effects of IPA have not been previously demonstrated. Therefore, this study focused on investigating the antimicrobial activity of IPA. Initially, antifungal activity of IPA against Candida albicans was observed, accompanied by variations in mitochondrial respiration indicating modulation of NAD(+)/NADH ratios. Consumption of O-2 contributes to the respiratory regulation and triggered by Ca2+ overloading. After treatment with IPA, the cells were monitored, and Ca2+ increases leading to membrane depolarization and reactive oxygen species (ROS) accumulation in mitochondria were noted. Depolarization of mitochondria membrane induced release of proapoptotic proteins in mitochondria. Oxidative stress exerted by ROS contributed to glutathione depletion and oxidation of glutathione (GSH). Fragmentation of DNA is a characteristic event leading to apoptosis and accompanies major hallmarks of apoptosis including phosphatidylserine exposure and metacaspase activation. In addition, phosphatidylserine exposure and metacaspase activation were detected in the cell treated with IPA. In conclusion, IPA triggered apoptosis in C. albicans under the influence of Ca2+. | Han, Giyeol; Lee, Dong Gun | Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea | Lee, Dong-Gun/IWD-9833-2023 | 57363202000; 55668060900 | dglee222@knu.ac.kr; | IUBMB LIFE | IUBMB LIFE | 1521-6543 | 1521-6551 | 74 | 3 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CELL BIOLOGY | 2022 | 4.6 | 33.9 | 0.65 | 2025-06-25 | 8 | 7 | apoptosis; calcium; Candida albicans; indole propionic acid; reactive oxygen species | MITOCHONDRIAL PERMEABILITY TRANSITION; CYTOCHROME-C; CELL-DEATH; CALCIUM; PHOSPHATIDYLSERINE; PATHOGENICITY; RESPIRATION; RESISTANCE; ASSAY; ROS | apoptosis; calcium; Candida albicans; indole propionic acid; reactive oxygen species | Antifungal Agents; Apoptosis; Candida albicans; Glutathione; Indoles; Membrane Potential, Mitochondrial; Phosphatidylserines; Propionates; Reactive Oxygen Species; 2 propanol; adenosine triphosphate; alcohol dehydrogenase; calcineurin inhibitor; calcium; calcium channel blocking agent; calcium ion; cyclosporine; cytochrome c; glutathione; glycerol 3 phosphate dehydrogenase (NAD); hydrogen peroxide; indolepropionic acid; mitochondrial DNA; mitochondrial permeability transition pore; nicotinamide adenine dinucleotide; phosphatidylserine; propionic acid; reactive oxygen metabolite; reduced nicotinamide adenine dinucleotide; ruthenium; antifungal agent; indole derivative; phosphatidylserine; propionic acid derivative; antifungal activity; antimicrobial activity; apoptosis; Article; Aspergillus flavus; calcium homeostasis; Candida albicans; Candida parapsilosis; cell respiration; cell survival; controlled study; depolarization; DNA fragmentation; electrochemical analysis; enzyme linked immunosorbent assay; flow cytometry; glycolysis; intestine flora; Malassezia furfur; membrane depolarization; metabolite; minimum inhibitory concentration; mitochondrial membrane potential; mitochondrial permeability; mitochondrial respiration; mitochondrion; MTT assay; nonhuman; oxidative stress; respiration control; Saccharomyces cerevisiae; Trichophyton rubrum; Trichosporon beigelii; TUNEL assay; apoptosis; metabolism | English | 2022 | 2022-03 | 10.1002/iub.2579 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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