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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Potential for antioxidant and antihyperglycemic activities of four everbearing strawberry cultivars | 'Goha', 'Gangha', 'Gwanha', and 'Yeolha' are newly-developed Korean everbearing strawberry (Fragaria ananassa Duch.) cultivars. Bioactive phytochemicals play a crucial role in the prevention of cancer, cardiovascular, neurodegenerative, and metabolic diseases. We examined the free radical scavenging activity and alpha-glucosidase inhibitory activity in these four cultivars and a junebearing cultivar 'Seolhyang' for comparison. 'Gwanha' showed the strongest 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2 '-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radical scavenging activities, and 'Gwanha' and 'Goha' had the most potent alpha-glucosidase inhibitory activity. Total anthocyanin content (TAC) was the highest in 'Gwanha'. The major anthocyanin components of everbearing strawberry were determined to be pelargonidin-3-O-glucoside (Pg3G), pelargonidin-3-O-rutinoside, and cyanidin-3-O-glucoside (C3G). A correlation study between activity and components revealed that TAC was highly correlated with antioxidant and antihyperglycemic activities, and in principal component analysis, C3G is highly correlated with antioxidant activity and Pg3G is highly correlated with the antihyperglycemic effect of everbearing strawberries. Among the four everbearing strawberry cultivars, 'Gwanha' and 'Goha' are rich sources of pelargonidin showing strong alpha-glucosidase inhibitory activity and are promising dietary sources to prevent diabetes. | Park, Mi Jin; Ryu, Da Hye; Cho, Jwa Yeong; Lee, Dong Gyu; Lee, Jong Nam; Kang, Young-Hwa | Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Hort Sci, Daegu, South Korea; Natl Inst Crop Sci, Highland Agr Res Ctr, Pyeongchang, South Korea | 56319353100; 57204860688; 57204858003; 57216412573; 56651301300; 56423929300 | kkkyhyh@hanmail.net; | HORTICULTURE ENVIRONMENT AND BIOTECHNOLOGY | HORTIC ENVIRON BIOTE | 2211-3452 | 2211-3460 | 61 | 3 | SCIE | HORTICULTURE | 2020 | 1.842 | 36.5 | 0.5 | 2025-06-25 | 7 | 8 | Antihyperglycemic activity; Antioxidant; Anthocyanins; Everbearing strawberry; Pelargonidin | ALPHA-GLUCOSIDASE; ANTHOCYANIN PIGMENTS; HEALTH-BENEFITS; AQUEOUS EXTRACT; PHENOLIC-ACIDS; COMPONENTS; FRUITS; PCA | Anthocyanins; Antihyperglycemic activity; Antioxidant; Everbearing strawberry; Pelargonidin | English | 2020 | 2020-06 | 10.1007/s13580-020-00240-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Waterlogging tolerance in apple trees grafted on rootstocks from G, CG, and M series | This study was performed to evaluate the waterlogging tolerance of Cornell-Geneva (G11, G202, G214, G935, CG4814, and CG5087), M26, and M9 apple rootstocks. After grafting 'Fuji' scions on each type of rootstock, grafted trees were planted in 17-L pots and grown in a greenhouse under well-irrigated conditions. Sixteen weeks after planting, grown trees were divided into two groups: one group was drip-irrigated daily with 2 L of water (control treatment, CT), and the other group was waterlogged by repeating flooding and drainage at 1- to 3-day intervals for 4 weeks (waterlogging treatment, WT). After the cessation of flooding, trees were irrigated as in CT for 18 days. Trees grafted on G202, G214, and M9 had markedly lower leaf water potential than CT trees on the 27th day of flooding; predawn leaf water potential was - 1.26 to - 1.45 MPa in WT trees and - 0.30 to - 0.32 MPa in CT trees, and midday leaf water potential was - 2.85 to - 3.03 MPa in WT trees and - 1.83 to - 1.87 MPa in CT trees. This difference persisted until the 18th day after the cessation of flooding. The net photosynthetic rate and stomatal conductance of trees grafted on these rootstocks were also extremely low in WT trees, and they did not recover to the corresponding levels in CT trees until the 18th day after the cessation of flooding. Among WT trees, the height, trunk cross-sectional area, and dry weight of G202, G214, and M9 trees were markedly lower than those of trees grafted on other rootstocks, whereas CG4814 trees showed the least reduction in these parameters. The defoliation percentages of G202, G214, and M9 trees were 22%, 23%, and 35%, respectively, in WT trees, whereas trees grafted on other rootstocks had 4 to 9% defoliation. Thus, G202 and G214 trees showed similar sensitivity levels as M9 trees, whereas CG4814 trees were more resistant to flooding than M26 trees, and G11, G935, and CG5087 trees showed a waterlogging tolerance comparable to M26 trees. | Choi, Byeong-Ho; Bhusal, Narayan; Jeong, Woo-Tae; Park, In-Hee; Han, Su-Gon; Yoon, Tae-Myung | Kyungpook Natl Univ, Dept Hort Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Apple Res Inst, Daegu 41566, South Korea | Bhusal, Narayan/AAE-9086-2019 | 57212379669; 57199327486; 57217307960; 57217313022; 57199650006; 50263701700 | tmyoon@knu.ac.kr; | HORTICULTURE ENVIRONMENT AND BIOTECHNOLOGY | HORTIC ENVIRON BIOTE | 2211-3452 | 2211-3460 | 61 | 4 | SCIE | HORTICULTURE | 2020 | 1.842 | 36.5 | 0.23 | 2025-06-25 | 6 | 7 | Flooding; Geneva apple rootstocks; Irrigation; Malus domestica; Water potential | GROWTH; SEEDLINGS; ROOT; PERFORMANCE; ETHYLENE | Flooding; Geneva apple rootstocks; Irrigation; Malus domestica; Water potential | English | 2020 | 2020-08 | 10.1007/s13580-020-00258-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Pharmacokinetics, tissue residues, and ex vivo pharmacodynamics of tylosin against Mycoplasma anatis in ducks | The pharmacokinetics of tylosin were investigated in 3 groups of ducks (n = 6). They received a single dose of tylosin (50 mg/kg) by intravenous (IV), intramuscular (IM), and oral administrations, respectively. Plasma samples were collected at various time points to 24 hr post-administration to evaluate tylosin concentration over time. Additionally, tylosin residues in tissues and its withdrawal time were assessed using 30 ducks which received tylosin orally (50 mg/kg) once daily for 5 consecutive days. After IV administration, the volume of distribution, elimination half-life, area under the plasma concentration-time curve, and the total body clearance were 7.07 +/- 1.98 L/kg, 2.04 hr, 19.47 mu g hr/ml, and 2.82 L hr(-1) kg(-1), respectively. After IM and oral administrations, the maximum plasma concentrations were 3.70 and 2.75 mu g/ml achieved at 1 and 2 hr, and the bioavailability was 93.95% and 75.77%, respectively. The calculated withdrawal periods of tylosin were 13, 8, and 5 days for kidney, liver, and muscle, respectively. For the pharmacodynamic profile, the minimum inhibitory concentration for tylosin against M. anatis strain 1,340 was 1 mu g/ml. The calculated optimal oral dose of tylosin against M. anatis in ducks based on the ex vivo pharmacokinetic/pharmacodynamic modeling was 61 mg kg(-1) day(-1). | Elazab, Sara T.; Elshater, Nahla S.; Hashem, Yousreya H.; Park, Seung-Chun; Hsu, Wafter H. | Mansoura Univ, Fac Vet Med, Dept Pharmacol, Mansoura, Egypt; Anim Hlth Res Inst, Reference Lab Vet Qual Control Poultry Prod, Giza, Egypt; Anim Hlth Res Inst, Mycoplasma Res Dept, Giza, Egypt; Kyungpook Natl Univ, Coll Vet Med, Lab Vet Pharmacokinet & Pharmacodynam, Daegu, South Korea; Iowa State Univ, Coll Vet Med, Dept Biomed Sci, Ames, IA 50011 USA | Elazab, Sara/L-8955-2018; Park, Seung-Chun/AAV-3388-2021 | 57195244229; 57211744199; 57209322857; 7501832396; 7402002883 | whsu@iastate.edu; | JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS | J VET PHARMACOL THER | 0140-7783 | 1365-2885 | 43 | 1 | SCIE | PHARMACOLOGY & PHARMACY;VETERINARY SCIENCES | 2020 | 1.786 | 36.6 | 0.82 | 2025-06-25 | 8 | 7 | ex vivo pharmacodynamics; high-performance liquid chromatography; pharmacokinetics; Tylosin; withdrawal time | DISPOSITION KINETICS; DEPLETION; TARTRATE; BIOAVAILABILITY; ANTIBIOTICS; CHICKENS; GROWTH; MILK; COWS | ex vivo pharmacodynamics; high-performance liquid chromatography; pharmacokinetics; Tylosin; withdrawal time | Animals; Anti-Bacterial Agents; Area Under Curve; Drug Residues; Ducks; Half-Life; Microbial Sensitivity Tests; Mycoplasma; Mycoplasma Infections; Tylosin; tylosin; antiinfective agent; drug residue; tylosin; absorption half-life; animal experiment; animal tissue; antimicrobial activity; area under the curve; Article; Cairina moschata; controlled study; drug bioavailability; drug blood level; drug clearance; drug distribution; drug tissue level; elimination half-life; ex vivo study; female; first order rate constant; male; maximum plasma concentration; mean absorption time; mean residence time; minimum inhibitory concentration; Mycoplasma; Mycoplasma anatis; nonhuman; plasma concentration-time curve; plasma protein binding; priority journal; single drug dose; time to maximum plasma concentration; volume of distribution; animal; drug effect; duck; half life time; microbial sensitivity test; microbiology; Mycoplasma; mycoplasmosis; veterinary medicine | English | 2020 | 2020-01 | 10.1111/jvp.12819 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | A novel sphingosylphosphorylcholine and sphingosine-1-phosphate receptor 1 antagonist, KRO-105714, for alleviating atopic dermatitis | Background Atopic dermatitis (eczema) is a type of inflammation of the skin, which presents with itchy, red, swollen, and cracked skin. The high global incidence of atopic dermatitis makes it one of the major skin diseases threatening public health. Sphingosylphosphorylcholine (SPC) and sphingosine-1-phosphate (S1P) act as pro-inflammatory mediators, as an angiogenesis factor and a mitogen in skin fibroblasts, respectively, both of which are important biological responses to atopic dermatitis. The SPC level is known to be elevated in atopic dermatitis, resulting from abnormal expression of sphingomyelin (SM) deacylase, accompanied by a deficiency in ceramide. Also, S1P and its receptor, sphingosine-1-phosphate receptor 1 (S1P1) are important targets in treating atopic dermatitis. Results In this study, we found a novel antagonist of SPC and S1P1, KRO-105714, by screening 10,000 compounds. To screen the compounds, we used an SPC-induced cell proliferation assay based on a high-throughput screening (HTS) system and a human S1P1 protein-based [S-35]-GTP gamma S binding assay. In addition, we confirmed the inhibitory effects of KRO-105714 on atopic dermatitis through related cell-based assays, including a tube formation assay, a cell migration assay, and an ELISA assay on inflammatory cytokines. Finally, we confirmed that KRO-105714 alleviates atopic dermatitis symptoms in a series of mouse models. Conclusions Taken together, our data suggest that SPC and S1P1 antagonist KRO-105714 has the potential to alleviate atopic dermatitis. | Yoon, Sae-Bom; Lee, Chang Hoon; Kim, Hyun Young; Jeong, Daeyoung; Jeon, Moon Kook; Cho, Sun-A; Kim, Kwangmi; Lee, Taeho; Yang, Jung Yoon; Gong, Young-Dae; Cho, Heeyeong | Korea Res Inst Chem Technol, Drug Discovery Platform Res Ctr, Therapeut & Biotechnol Div, 141 Gajeong Ro, Daejeon 34114, South Korea; Seoul Natl Univ, Coll Vet Med, BK21PLUS Program Creat Vet Sci Res, Dept Lab Anim Med,Res Inst Vet Sci, Seoul 08826, South Korea; Danguk Univ, Coll Pharm, 119 Dandae Ro, Cheonan 31116, Chungnam, South Korea; Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Daegu 702701, South Korea; Dongguk Univ, Sci Coll, Innovat Drug Lib Res Ctr, Seoul 100715, South Korea; Korea Univ Sci & Technol, Med Chem & Pharmacol, Daejeon, South Korea | ; Cho, Kwang/J-5661-2012 | 57216992334; 57219136939; 59052034500; 10439859900; 9437313900; 36119856800; 35083677600; 57204032003; 57194946980; 7402475311; 9736605300 | ydgong@dongguk.edu;hycho@krict.re.kr; | JOURNAL OF INFLAMMATION-LONDON | J INFLAMM-LOND | 1476-9255 | 17 | 1 | SCIE | IMMUNOLOGY | 2020 | 4.981 | 36.7 | 0.4 | 2025-06-25 | 7 | 9 | Sphingosylphosphorylcholine; Sphingosine-1-phosphate receptor 1; Antagonist; Anti-inflammatory; Atopic dermatitis; High-throughput screening | MONOCYTE CHEMOATTRACTANT PROTEIN-1; RETRACTED ARTICLE. SEE; PLASMINOGEN-ACTIVATOR; EXPRESSION; CELLS; SPHINGOMYELIN; LIGAND; G2A; INVOLVEMENT; INDUCTION | Antagonist; Anti-inflammatory; Atopic dermatitis; High-Throughput screening; Sphingosine-1-phosphate receptor 1; Sphingosylphosphorylcholine | dermatological agent; kro 105714; unclassified drug; animal cell; animal experiment; animal model; animal tissue; Article; atopic dermatitis; Bagg albino mouse; cell migration assay; cell proliferation assay; clinical effectiveness; controlled study; cytokine production; dose response; drug effect; drug efficacy; drug mechanism; drug structure; embryo; enzyme linked immunosorbent assay; GTPgammaS binding assay; high throughput screening; human; human cell; Institute for Cancer Research mouse; male; mouse; nonhuman; treatment outcome | English | 2020 | 2020-05-29 | 10.1186/s12950-020-00244-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Noninvasive in vivo cell tracking using molecular imaging: A useful tool for developing mesenchymal stem cell-based cancer treatment | Mounting evidence has emphasized the potential of cell therapies in treating various diseases by restoring damaged tissues or replacing defective cells in the body. Cell therapies have become a strong therapeutic modality by applying noninvasive in vivo molecular imaging for examining complex cellular processes, understanding pathophysiological mechanisms of diseases, and evaluating the kinetics/dynamics of cell therapies. In particular, mesenchymal stem cells (MSCs) have shown promise in recent years as drug carriers for cancer treatment. They can also be labeled with different probes and tracked in vivo to assess the in vivo effect of administered cells, and to optimize therapy. The exact role of MSCs in oncologic diseases is not clear as MSCs have been shown to be involved in tumor progression and inhibition, and the exact interactions between MSCs and specific cancer microenvironments are not clear. In this review, a multitude of labeling approaches, imaging modalities, and the merits/demerits of each strategy are outlined. In addition, specific examples of the use of MSCs and in vivo imaging in cancer therapy are provided. Finally, present limitations and future outlooks in terms of the translation of different imaging approaches in clinics are discussed. | Rajendran, Ramya Lakshmi; Jogalekar, Manasi Pandurang; Gangadaran, Prakash; Ahn, Byeong-Cheol | Kyungpook Natl Univ, Dept Nucl Med, Daegu 41944, South Korea; Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 Plus KNU Biomed Convergence Program, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Nucl Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea | Rajendran, Ramya/AAV-6338-2021; Gangadaran, Prakash/AAV-3102-2021; Jogalekar, Manasi/AAG-6925-2020 | 57195318729; 57194462336; 54393130400; 7202791511 | abc2000@knu.ac.kr; | WORLD JOURNAL OF STEM CELLS | WORLD J STEM CELLS | 1948-0210 | 12 | 12 | SCIE | CELL & TISSUE ENGINEERING;CELL BIOLOGY | 2020 | 5.326 | 36.7 | 0.6 | 2025-06-25 | 10 | 11 | Cell therapy; Mesenchymal stem cells; In vivo molecular imaging; Drug delivery; Superparamagnetic iron oxide | GENE-EXPRESSION; REPORTER GENE; STROMAL CELLS; QUANTUM DOTS; ISCHEMIC CARDIOMYOPATHY; DRUG-DELIVERY; TUMOR-GROWTH; TRANSPLANTATION; THERAPY; VITRO | Cell therapy; Drug delivery; In vivo molecular imaging; Mesenchymal stem cells; Superparamagnetic iron oxide | superparamagnetic iron oxide; Article; bioluminescence; cancer therapy; cell therapy; cell tracking; drug delivery system; fluorescence imaging; human; in vivo study; mesenchymal stem cell; mesenchymal stem cell transplantation; molecular imaging; multimodal imaging; non invasive procedure; nuclear magnetic resonance imaging; positron emission tomography | English | 2020 | 2020-12-26 | 10.4252/wjsc.v12.i12.1492 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Treatment of synthetic textile dye effluent using hybrid adsorptive ultrafiltration mixed matrix membranes | Textile industries are facing critical issues in dyes disposal and water reclamation. In this regards, emerging adsorptive membranes have shown tremendous potential for the removal of contaminants from wastewaters. As-prepared iron doped TiO2 nanotubes (FeTNT) and silver doped TiO2 nanotubes (AgTNT) are embedded in polyethersulfone (PES) matrix for adsorptive removal of rhodamine B dye from textile wastewater. SEM and EDX revealed that Fe and Ag were attached on the FeTNT and AgTNT nanocomposites respectively. Mixed matrix membranes (MMMs) morphological analysis revealed a spongy structure with less macrovoid formation. The addition of hydrophilic TNT enhanced the surface free energy and water permeability of the resulting MMMs. For rhodamine B batch adsorption, pH 2 was found to be optimum for maximum removal efficiency using MMMs incorporated with 0.4 wt% FeTNT. Sips isotherm and second order Lagregren model are good correlation with rhodamine B adsorption data of pristine PES and functionalized PES MMMs. A maximum rhodamine B removal efficiency of 97% was observed in FeTNTePES MMMs at the transmembrane pressure (TMP) of 200 kPa. The influence of sodium sulfate on rhodamine B removal was also studied for continuous filtration system. The findings of this study indicated that FeTNT MMMs is an effective adsorptive membrane for dye wastewater reclamation at low TMP. (C) 2020 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved. | Thuyavan, Y. Lukka; Arthanareeswaran, G.; Ismail, A. F.; Goh, P. S.; Shankar, M., V; Reddy, N. Lakshmana | Natl Inst Technol, Dept Chem Engn, Membrane Res Lab, Tiruchirappalli 620015, Tamil Nadu, India; Univ Teknol Malaysia, Adv Membrane Technol Res Ctr AMTEC, Skudai 81310, Johor, Malaysia; Yogi Vemana Univ, Dept Mat Sci & Nanotechnol, Nanocatalysis & Solar Fuels Res Lab, Kadapa 516005, Andhra Pradesh, India; Kyungpook Natl Univ, Sch Nano & Mat Sci & Engn, 2559 Gyeongsang Daero, Sangju, Gyeongbuk, South Korea | Arthanareeswaran, Gangasalam/M-3798-2019; Venkatakrishnan, Shankar/AAC-1460-2019; Nagappagari, Lakshmana Reddy/K-2238-2019; N, Dr. Lakshmana Reddy/K-2238-2019; Arthanareeswaran, Dr. Gangasalam/L-6341-2013; Yogarathinam, Lukka/AEP-3788-2022; Muthukonds Venkatakrishnan, Shankar/AAC-1460-2019 | lukkathuyavan@gmail.com;arthanaree10@yahoo.com;afauzi@utm.my; | CHEMICAL ENGINEERING RESEARCH & DESIGN | CHEM ENG RES DES | 0263-8762 | 1744-3563 | 159 | SCIE | ENGINEERING, CHEMICAL | 2020 | 3.739 | 36.7 | 20 | Mixed matrix membrane; TiO2 nanotubes; Rhodamine B; Adsorption; Continuous filtration | RHODAMINE-B; NANOFILTRATION MEMBRANES; COMPOSITE MEMBRANE; HYDROGEN-PRODUCTION; TIO2 NANOPARTICLES; AQUEOUS-SOLUTION; METAL-OXIDES; WASTE-WATER; REMOVAL; SIZE | English | 2020 | 2020-07 | 10.1016/j.cherd.7070.04.005 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Assessment of biomass potentials of microalgal communities in open pond raceways using mass cultivation | Metagenome studies have provided us with insights into the complex interactions of microorganisms with their environments and hosts. Few studies have focused on microalgae-associated metagenomes, and no study has addressed aquatic microalgae and their bacterial communities in open pond raceways (OPRs). This study explored the possibility of using microalgal biomasses from OPRs for biodiesel and biofertilizer production. The fatty acid profiles of the biomasses and the physical and chemical properties of derived fuels were evaluated. In addition, the phenotype-based environmental adaptation ability of soybean plants was assessed. The growth rate, biomass, and lipid productivity of microalgae were also examined during mass cultivation from April to November 2017. Metagenomics analysis using MiSeq identified similar to 127 eukaryotic phylotypes following mass cultivation with (OPR 1) or without (OPR 3) a semitransparent film. Of these, similar to 80 phylotypes were found in both OPRs, while 23 and 24 phylotypes were identified in OPRs 1 and 3, respectively. The phylotypes belonged to various genera, such as Desmodesmus, Pseudopediastrum, Tetradesmus, and Chlorella, of which, the dominant microalgal species was Desmodesmus sp. On average, OPRs 1 and 3 produced similar to 8.6 and 9.9 g m(-2) d(-1) (0.307 and 0.309 DW L-1) of total biomass, respectively, of which 14.0 and 13.3 wt% respectively, was lipid content. Fatty add profiling revealed that total saturated fatty acids (mainly C16:0) of biodiesel obtained from the microalgal biomasses in OPRs 1 and 3 were 34.93% and 32.85%, respectively; total monounsaturated fatty adds (C16:1 and C18:1) were 32.40% and 31.64%, respectively; and polyunsaturated fatty adds (including C18:3) were 32.68% and 35.50%, respectively. Fuel properties determined by empirical equations were within the limits of biodiesel standards ASTM D6751 and EN 14214. Culture solutions with or without microalgal biomasses enhanced the environmental adaptation ability of soybean plants, increasing their seed production. Therefore, microalgal biomass produced through mass cultivation is excellent feedstock for producing high-quality biodiesel and biofertilizer. | Jo, Seung-Woo; Do, Jeong-Mi; Na, Ho; Hong, Ji Won; Kim, Il-Sup; Yoon, Ho-Sung | Kyungpook Natl Univ, Dept Energy Sci, Daegu, South Korea; Kyungpook Natl Univ, Dept Biol, Daegu, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 Plus KNU Creat BioRes Grp, Daegu, South Korea; Kyungpook Natl Univ, Dept Hydrogen & Renewable Energy, Daegu, South Korea; Kyungpook Natl Univ, Adv Bioresource Res Ctr, Daegu, South Korea | 56018962600; 57208562245; 57211975842; 57201579963; 55477678200; 7402990205 | 92kis@hanmail.net;hsy@knu.ac.kr; | PEERJ | PEERJ | 2167-8359 | 8 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 2.984 | 36.8 | 1.12 | 2025-06-25 | 18 | 21 | Mass cultivation; MiSeq; Microalgal community; Biodiesel; Biofertilizer | WASTE-WATER TREATMENT; LIPID-ACCUMULATION; GREEN MICROALGA; ORGANIC-CARBON; BIODIESEL; GROWTH; FUEL; PRODUCTIVITY; DIVERSITY; STRAINS | Biodiesel; Biofertilizer; Mass cultivation; Microalgal community; MiSeq | arachidonic acid; behenic acid; biodiesel; carbon; fatty acid; growth factor; hydrogen; icosapentaenoic acid; iodine; linolenic acid; monounsaturated fatty acid; myristic acid; nitrogen; oleic acid; palmitic acid; palmitoleic acid; phosphorus; polyunsaturated fatty acid; saturated fatty acid; algal cell culture; amoeboaphelidium; Article; biodiversity; biomass; Chlamydomonadales; Chlorella; coelastrum; colorimetry; Cryptophyta; cyanobacterium; Desmodesmus; dinoflagellate; growth rate; heterocypris; lipid fingerprinting; mass fragmentography; metagenome; microalga; microbial community; nonhuman; open pond raceway; phenotype; pond; pseudodifflugia; pseudopediastrum; saponification; soybean; tetradesmus; thermogravimetry | English | 2020 | 2020-07-16 | 10.7717/peerj.9418 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | Effect of a Nationwide Real-Time Drug Utilization Review System on Duplicated Nonsteroidal Antiinflammatory Drug Prescriptions in Korea | Objective Since January 2013, a nationwide drug utilization review (DUR) system for therapeutic duplication (TD) of nonsteroidal antiinflammatory drugs (NSAIDs) has been implemented in Korea. Our objective was to perform an interrupted time series study to assess changes in the pattern of NSAIDs use in knee osteoarthritis patients after implementation of the regulations. Methods We compared the prescribing patterns in 2012 and 2013 by means of an interrupted time series study, using the Health Insurance Review and Assessment Service database. TD was defined as use of concurrent NSAIDs either on the same or on different prescriptions for >3 days in a patient. Level change and trend change (with 95% confidence intervals [95% CIs]), and absolute and relative changes in the proportion of TDs, were estimated using segmented regression models. Multivariable logistic regression models were used to explore patient and provider characteristics associated with the TDs. Results Approximately 2.5 million patients were prescribed NSAIDs in both 2012 and 2013. The proportion of TDs before and after introduction of the DUR system was 7.4% and 5.6%, respectively. Overall, an absolute reduction of 89% and a relative reduction of 30% in TDs were observed. In the postregulation period, older patients, medical aid subscribers (odds ratio [OR] 1.87 [95% CI 1.84, 1.90]), and veterans (OR 3.28 [95% CI 3.10, 3.46]) were most likely to receive NSAID TDs. Conclusion The prescription of NSAID TDs decreased with the introduction of the nationwide DUR system. Continuous adherence to the DUR regulations and safety monitoring are needed, especially with the elderly, medical aid subscribers, and veterans. | Jung, Sun-Young; Jang, Eun Jin; Choi, Seongmi; Im, Seul Gi; Kim, Dalho; Cho, Soo-Kyung; Kim, Hyoungyoung; Sung, Yoon-Kyoung | Chung Ang Univ, Seoul, South Korea; Andong Natl Univ, Andong, South Korea; Natl Hlth Insurance Serv, Wonju, South Korea; Kyungpook Natl Univ, Daegu, South Korea; Hanyang Univ Hosp Rheumat Dis, Seoul, South Korea | 57207445502; 37861741600; 57211676692; 57201022006; 57198636658; 35185890800; 57202108695; 15754508900 | sungyk@hanyang.ac.kr; | ARTHRITIS CARE & RESEARCH | ARTHRIT CARE RES | 2151-464X | 2151-4658 | 72 | 10 | SCIE | RHEUMATOLOGY | 2020 | 4.794 | 36.8 | 0.56 | 2025-06-25 | 7 | 7 | RISK; MANAGEMENT; INJURY | Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Drug Utilization Review; Female; Humans; Interrupted Time Series Analysis; Male; Middle Aged; Osteoarthritis, Knee; Prescriptions; nonsteroid antiinflammatory agent; nonsteroid antiinflammatory agent; adult; aged; Article; cerebrovascular disease; Charlson Comorbidity Index; chronic lung disease; comorbidity; congestive heart failure; diabetes mellitus; drug database; drug monitoring; drug safety; drug utilization review; female; health care personnel; health insurance; heart infarction; human; hypertension; kidney disease; knee osteoarthritis; Korea; liver disease; major clinical study; male; middle aged; peptic ulcer; peripheral vascular disease; prescription; prevalence; rheumatic disease; very elderly; veteran; epidemiology; knee osteoarthritis; prescription | English | 2020 | 2020-10 | 10.1002/acr.24054 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Intelligent Reflecting Surface: Joint Optimal Training Sequence and Refection Pattern | We investigate channel estimation for an intelligent reflecting surface (IRS) aided wireless communication system with a multi-antenna access point (AP), an multi-element IRS, and a set of multiple users, each with a single antenna. Our goal is to minimize mean square error (MSE) of estimating the channels of direct and cascaded links from the AP to each user via the IRS elements by jointly optimizing the training sequence of the AP and reflection pattern of the IRS. To solve this challenging problem, we first find the joint optimal structure and reflection pattern for the training sequence, and then, we convert the problem into a convex form to design the optimal training sequence efficiently. To reduce the computational complexity, we also propose a suboptimal training sequence in closed form. Numerical results show that the proposed scheme outperforms baseline schemes. | Kang, Jae-Mo | Kyungpook Natl Univ, Dept Artificial Intelligence, Daegu 41566, South Korea | 56024930400 | jmkang@knu.ac.kr; | IEEE COMMUNICATIONS LETTERS | IEEE COMMUN LETT | 1089-7798 | 1558-2558 | 24 | 8 | SCIE | TELECOMMUNICATIONS | 2020 | 3.436 | 36.8 | 2.21 | 2025-06-25 | 42 | 48 | Training; Channel estimation; Wireless communication; Mean square error methods; Computational complexity; Hardware; Signal to noise ratio; Channel estimation; intelligent reflecting surface (IRS); reflection pattern; training design; wireless communication | WIRELESS NETWORK; DESIGN | Channel estimation; intelligent reflecting surface (IRS); reflection pattern; training design; wireless communication | Antennas; Mean square error; Structural optimization; Access points; Intelligent reflecting surface; Optimal training sequences; Reflecting surface; Reflection patterns; Surface joints; Training design; Training sequences; Wireless communication system; Wireless communications; Channel estimation | English | 2020 | 2020-08 | 10.1109/lcomm.2020.2991178 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Nuclear security system effectiveness assessment using bounded analysis approach: a case study of different adversary scenarios | A security issue on nuclear facilities will give a significant effect on national security, economy, public health, or the combination among them. The evaluation of physical security effectiveness is done by considering it as a probability that the system will defeat an adversary at a particular time. This research examined the effectiveness of Physical Protection Systems (PPS) of a nuclear research reactor in Indonesia, as a role model facility. Three possible adversary scenarios were assessed. Estimation of Adversary Sequence Interruption model was implemented to assess the physical security system. The estimation of the effectiveness of physical-cybersecurity combination was done by Bounding Analysis Approach. The effectiveness of security system with cyber system working properly was assessed and compared with the system receiving cyber attacked. The results showed that the system effectiveness is high (0.839, 0.949, and 0.837, respectively). The results showed that the assessment method is effective to examine whether a security element is working effectively or not in such facility. This work will be useful as base guidelines for nuclear regulatory body and licensee for the application and evaluation of PPS and provision of countermeasure strategies in RSG GAS, and for further benefit, it can be used by nuclear facilities. | Syuryavin, Ahmad Ciptadi; Lee, Sang Hoon; Syam, Nur Syamsi | Kyungpook Natl Univ, Sch Energy Engn, Engn Bldg 7,Room 214,Daehak Ro 80, Daegu 41566, South Korea; Badan Pengawas Tenaga Nuklir Nucl Energy Regulato, Jakarta, Indonesia; Radiat Sci Res Inst RSRI, Daegu, South Korea | 57215836325; 56812964000; 57202036781 | a.ciptadi@bapeten.go.id; | JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY | J NUCL SCI TECHNOL | 0022-3131 | 1881-1248 | 57 | 9 | SCIE | NUCLEAR SCIENCE & TECHNOLOGY | 2020 | 1.599 | 36.8 | 0.18 | 2025-06-25 | 2 | 3 | Physical protection system; EASI; BAA; nuclear security | BAA; EASI; nuclear security; Physical protection system | Nuclear energy; Security systems; Bounding analysis; Countermeasure strategies; Nuclear facilities; Nuclear research reactor; Physical protection systems; Physical security systems; Regulatory bodies; System effectiveness; National security | English | 2020 | 2020-09-01 | 10.1080/00223131.2020.1771229 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Reinforcement Learning Based Adaptive Resource Allocation for Wireless Powered Communication Systems | Wireless powered communication (WPC) is one of the promising techniques for future energy-constrained wireless networks. In this letter, we consider a WPC system composed of a hybrid access point and an energy harvesting node (EHN). In this system, we propose a reinforcement learning based adaptive resource allocation scheme that dynamically assigns the channel resources to minimize the outage probability of information transfer while satisfying the average power constraint at the EHN, which is formulated as a constrained Markov decision process (MDP) problem. To solve this challenging problem, we first transform the originally formulated problem into its equivalent unconstrained MDP with multi-objective. Then, to find the resource allocation policy, we propose a novel Q-learning algorithm. Numerical results demonstrate the superior performance and effectiveness of the proposed scheme. | Kang, Jae-Mo | Kyungpook Natl Univ, Dept Artificial Intelligence, Daegu 41566, South Korea | 56024930400 | jmkang@knu.ac.kr; | IEEE COMMUNICATIONS LETTERS | IEEE COMMUN LETT | 1089-7798 | 1558-2558 | 24 | 8 | SCIE | TELECOMMUNICATIONS | 2020 | 3.436 | 36.8 | 0.95 | 2025-06-25 | 15 | 18 | Fading channels; Resource management; Probability; Power system reliability; Batteries; Learning (artificial intelligence); Adaptive systems; Energy harvesting; Q-learning; reinforcement learning; resource allocation; wireless powered communication | OPTIMIZATION | Energy harvesting; Q-learning; reinforcement learning; resource allocation; wireless powered communication | Constraint satisfaction problems; Energy harvesting; Learning algorithms; Learning systems; Markov processes; Resource allocation; Adaptive resource allocations; Constrained Markov decision process; Formulated problems; Information transfers; Numerical results; Outage probability; Q-learning algorithms; Resource allocation policy; Reinforcement learning | English | 2020 | 2020-08 | 10.1109/lcomm.2020.2988817 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Exploring the relationship between geomagnetic activity and human heart rate variability | Purpose Both geomagnetic and solar activity fluctuate over time and have been proposed to affect human physiology. Heart rate variability (HRV) has substantial health implications regarding the ability to adapt to stressors and has been shown to be altered in many cardiovascular and neurological disorders. Intriguingly, previous work found significant, strong correlations between HRV and geomagnetic/solar activity. The purpose of this study to replicate these findings. We simultaneously measured HRV during a 30-day period. Methods We recruited 20 healthy participants and measured their HRV for a 30-day period. We also collected geomagnetic and solar activity during this period for investigating their relationship with the HRV data. Results In agreement with previous work, we found several significant correlations between short-term HRV and geophysical time-series. However, after correction for autocorrelation, which is inherent in time-series, the only significant results were an increase in very low frequency during higher local geomagnetic activity and a geomagnetic anticipatory decrease in heart rate a day before the higher global geomagnetic activity. Both correlations were very low. The loss of most significant effects after this correction suggests that previous findings may be a result of autocorrelation. A further note of caution is required since our and the previous studies in the field do not correct for multiple comparisons given the exploratory analysis strategy. Conclusion We thus conclude that the effects of geomagnetic and solar activity are (if present) most likely of very small effect size and we question the validity of the previous studies given the methodological concerns we have uncovered with our work. | Mattoni, Matthew; Ahn, Sangtae; Frohlich, Carla; Frohlich, Flavio | Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA; Univ N Carolina, Carolina Ctr Neurostimulat, Chapel Hill, NC 27599 USA; Kyungpook Natl Univ, Sch Elect Engn, 41556, Daegu 41556, South Korea; North Carolina State Univ, Dept Phys, Raleigh, NC 27695 USA; Univ N Carolina, Dept Neurol, Chapel Hill, NC 27599 USA; Univ N Carolina, Dept Biomed Engn, Chapel Hill, NC 27599 USA; Univ N Carolina, Dept Cell Biol & Physiol, Chapel Hill, NC 27599 USA; Univ N Carolina, Neurosci Ctr, Chapel Hill, NC 27599 USA | ; Frohlich, Carla/C-4841-2012; Ahn, Sangtae/AFQ-7342-2022; Frohlich, Flavio/P-6429-2017 | 57216564402; 55468016100; 8281609700; 57204276548 | flavio_frohlich@med.unc.edu; | EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY | EUR J APPL PHYSIOL | 1439-6319 | 1439-6327 | 120 | 6 | SCIE | PHYSIOLOGY;SPORT SCIENCES | 2020 | 3.078 | 36.9 | 0.77 | 2025-06-25 | 9 | 10 | Heart rate variability; Geomagnetic activity; Solar activity | HUMAN HEALTH; FREQUENCY; SOLAR; SURROGATE | Geomagnetic activity; Heart rate variability; Solar activity | Adolescent; Adult; Female; Healthy Volunteers; Heart Rate; Humans; Longitudinal Studies; Magnetic Fields; Male; Solar Activity; Young Adult; adolescent; adult; female; heart rate; human; longitudinal study; magnetic field; male; normal human; physiology; solar energy; young adult | English | 2020 | 2020-06 | 10.1007/s00421-020-04369-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Letter | Letter to the Editor: Effect of fatty fish or nut consumption on concentrations of persistent organic pollutants in overweight or obese men and women: A randomized controlled clinical trial | Lee, Yu-Mi; Lee, Duk-Hee | Kyungpook Natl Univ, Sch Med, Dept Prevent Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Biomed Sci, BK21 Plus KNU Biomed Convergence Program, Daegu, South Korea | 57075191600; 57211851121 | lee_dh@knu.ac.kr; | NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | NUTR METAB CARDIOVAS | 0939-4753 | 1590-3729 | 30 | 5 | SCIE | CARDIAC & CARDIOVASCULAR SYSTEMS;ENDOCRINOLOGY & METABOLISM;NUTRITION & DIETETICS | 2020 | 4.222 | 36.9 | 0.17 | 2025-06-25 | 1 | 1 | ADIPOSE-TISSUE; CHEMICALS | Animals; Environmental Pollutants; Female; Humans; Male; Nuts; Obesity; Overweight; adipocyte; adipose tissue; body mass; carbohydrate diet; cardiometabolic risk; controlled study; fat intake; female; fish consumption; human; Letter; lipid composition; lipid diet; lipid storage; lipolysis; macronutrient; male; nut; obesity; physical activity; priority journal; protein diet; randomized controlled trial; risk factor; animal; obesity; pollutant | English | 2020 | 2020-05-07 | 10.1016/j.numecd.2020.01.015 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Computational Investigation on the Photophysical Properties of Halogenated Tetraphenyl BODIPY | The electronic structure, transition probabilities, and corresponding quantum yields of fluorescence in a family of dihalogen-tetraphenyl-aza-BODIPY were calculated at the Time-Dependent Density Functional and post-Hartree-Fock levels of theory. Excellent agreement between theoretical and experimental spectral-luminescent data was achieved with the HSE06 functional and the 6-311G* basis set. Because the fluorescence can be quenched through nonradiative intersystem spin crossing transitions from the lowest photoactive singlet state to triplet excited states, spin-orbit coupling matrix elements were calculated and applied along with Marcus-Levich-Jortner theory, leading to satisfactory agreement for the lifetimes in comparison with available experimental data. The anomalous dependence of the fluorescence efficiency on the atomic number of the halogen congeners was elucidated and shown to be due to an inversion between the fluorescent and the nearest triplet states in the iodinated compounds. The high rate of fluorescence quenching by intersystem crossings and the probability of collisions in a solvent between oxygen molecules and the molecules studied show that these molecules can provide efficient triplet sensitization. The most preferable sites for such interactions were predicted using electrostatic potential mapping at the extreme positive and negative charge points. | Pomogaev, Vladimir; Chiodo, Sandro; Ruud, Kenneth; Kuznetsova, Rimma; Avramov, Pavel | Kyungpook Natl Univ, Coll Nat Sci, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Green Nano Mat Res Ctr, Daegu 41566, South Korea; Natl Res Tomsk State Univ, Tomsk 634050, Russia; Inst Charles Gerhardt Montpellier, CNRS ENSCM UM1 UM2, F-34296 Montpellier 5, France; Univ Tromso Arctic Univ Norway, Hylleraas Ctr Quantum Mol Sci, Dept Chem, N-9037 Tromso, Norway | Kuznetsova, Rimma/E-5291-2014; Pomogaev, Vladimir/E-5049-2014; Ruud, Kenneth/E-5947-2010 | 6603016010; 6603002152; 7005489962; 7006908731; 7004322420 | helperv@gmail.com;paul.veniaminovich@knu.ac.kr; | JOURNAL OF PHYSICAL CHEMISTRY C | J PHYS CHEM C | 1932-7447 | 1932-7455 | 124 | 20 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2020 | 4.126 | 37.0 | 0.37 | 2025-06-25 | 8 | 8 | SINGLET OXYGEN GENERATION; BASIS-SETS; EXCITED-STATES; SPECTROSCOPIC PROPERTIES; DENSITY FUNCTIONALS; BORON; ELEMENTS; DYES; AZA; APPROXIMATION | Atoms; Computation theory; Electronic structure; Excited states; Fluorescence; Halogen compounds; Molecules; Quenching; Spin orbit coupling; Computational investigation; Electrostatic potentials; Fluorescence efficiency; Inter-system crossings; Photophysical properties; Time-dependent density; Transition probabilities; Triplet sensitization; Density functional theory | English | 2020 | 2020-05-21 | 10.1021/acs.jpcc.0c01742 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Rapid Determination of Benzylpenicillin Resistance in Staphylococcus aureus Bacteraemia Model | Rapid determination of antimicrobial susceptibility/resistance is an important factor in selecting an appropriate antimicrobial treatment and eradicating infections promptly. Conventional antimicrobial susceptibility tests (ASTs) are very time consuming. Thus, we developed a liquid chromatography-mass spectrometry (LC-MS/MS) method for rapidly determining the resistance of Staphylococcus aureus to penicillin-G in an animal-infection model. This technique will be able to detect those resistant strains whose resistance mechanism specifically controlled by penicillinase. The resistance status of S. aureus against penicillin-G was determined by conventional AST. Cultured S. aureus cells were inoculated to chicken for developing bacteraemia. The solution of penicillin-G was intravenously administered (10 mg/kg b.w.) to chickens just after infection detection. Blood samples were collected at different intervals after drug administration. The concentration of active penicillin-G and its metabolites were determined from the bacteria-free blood supernatant by utilizing the LC-MS/MS method. Evidence of infection in chicken was observed within 5 h of bacterial inoculation. The penicillinase enzyme generated by S. aureus transforms the active penicillin-G to an inactive metabolite by hydrolysis, which is evident by the mass shift from 335.10600 to 353.11579 Da as quantified using liquid chromatography quadrupole time-of-flight mass spectrometry (LC/Q-TOF/MS). The signal intensity of inactive/hydrolysed penicillin-G is several-fold greater than that of the active penicillin-G in the blood sample of chicken infected with resistant strain and treated with penicillin-G. The antimicrobial resistance index (ARI) value of resistant S. aureus strain was more than 1, demonstrating the penicillin-G-resistance pattern of that strain. This method is able to determine the extent of beta-lactam antimicrobial resistance within 1.5 h from the patient's blood and is complementary with those existing AST methods which are usually practicing in the evaluation of beta-lactam antibiotic resistance. | Kang, JeongWoo; Hossain, Md Akil; Park, Hae-chul; Kim, Yong-sang; Park, Sung-won; Kim, Tae-Wan | APQA, Vet Drugs & Biol Div, Gimcheon Si, Gyeongsangbuk D, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Physiol, Daegu, South Korea | Kim, Young Dok/ABG-8986-2021; Hossain, Akil/AAY-7229-2020; Park, Sung-Won/AEL-2300-2022 | 57212201397; 55754133800; 57210463034; 57207443604; 55803248200; 57202769925 | hijach@korea.kr; | INFECTION AND DRUG RESISTANCE | INFECT DRUG RESIST | 1178-6973 | 13 | SCIE | INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY | 2020 | 4.003 | 37.1 | 0 | 2025-06-25 | 1 | 1 | beta-lactamase; spectrometry; antibacterial susceptibility test; chicken infection model; antibacterial resistance | MASS-SPECTROMETRY | Antibacterial resistance; Antibacterial susceptibility test; Chicken infection model; Spectrometry; β-lactamase | penicillin G; penicillinase; penicilloic acid; animal experiment; animal model; antibiotic resistance; antibiotic sensitivity; Article; bacterial cell; bacterial strain; blood sampling; chicken; controlled study; drug blood level; hydrolysis; inoculation; liquid chromatography-mass spectrometry; male; minimum inhibitory concentration; nonhuman; staphylococcal bacteremia; supernatant | English | 2020 | 2020 | 10.2147/idr.s243826 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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