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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Reduced-Intensity Conditioning with Busulfan and Fludarabine for Allogeneic Hematopoietic Stem Cell Transplantation in Acute Lymphoblastic Leukemia | Purpose: Allogeneic hematopoietic stem cell transplantation (HSCT) with optimal conditioning has helped better long-term survival in acute lymphoblastic leukemia (ALL). This study investigated the efficacy and safety of reduced-intensity conditioning (RIC) with busulfan and fludarabine in adult ALL patients unfit for myeloablation. Materials and Methods: Records of 78 patients who underwent HSCT with RIC consisting of 3.2 mg/kg/day of busulfan for 2 or 3 days and 30 mg/m(2)/day of fludarabine for 5 or 6 days were analyzed. Results: The median age at diagnosis was 49 years. Over a median follow-up of 22 months, 2-year estimates of relapse-free survival (RFS) and overall survival were 57.4% and 68.7%, respectively. Multivariate analysis showed a trend of improved RFS in patients with chronic graft-versus-host disease (GVHD) (hazard ratio, 0.53; 95% confidence interval, 0.26-1.08; p=0.080). The cumulative incidences of relapse and non-relapse mortality were 42.9% and 19.6%, respectively and one case of central nervous system relapse was noted. No hepatic veno-occlusive disease was reported. Grade II-IV acute GVHD and any grade chronic GVHD occurred in 21.1% and 41.7%, respectively. Conclusion: RIC with busulfan and fludarabine is an effective and safe conditioning regimen for adult ALL patients unfit for myeloablation. | Lee, Seung-Shin; Jung, Sung-Hoon; Do, Young Rok; Kim, Dae Sik; Lee, Ji Hyun; Park, Han-Seung; Moon, Joon Ho; Yi, Jun Ho; Park, Yong; Koh, Youngil; Yhim, Ho-Young; Choi, Yunsuk; Mun, Yeung-Chul; Lee, Won-Sik; Lee, Seok; Yang, Deok-Hwan | Wonkwang Univ Hosp, Dept Hematol & Oncol, Iksan, South Korea; Chonnam Natl Univ, Dept Hematol Oncol, Hwasun Hosp, 322 Seoyang Ro, Hwasun 58128, South Korea; Keimyung Univ, Dongsan Med Ctr, Dept Hematol Oncol, Sch Med, Daegu, South Korea; Korea Univ, Guro Hosp, Dept Internal Med, Div Hematol Oncol,Sch Med, Seoul, South Korea; Dong A Univ, Dong A Med Ctr, Dept Hematol Oncol, Coll Med, Busan, South Korea; Univ Ulsan, Asan Med Ctr, Dept Hematol, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Hematol & Oncol, Daegu, South Korea; Chung Ang Univ, Dept Med, Div Hematol Oncol, Seoul, South Korea; Korea Univ, Anam Hosp, Dept Internal Med, Div Hematol Oncol,Sch Med, Seoul, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Dept Internal Med, Med Sch, Jeonju, South Korea; Univ Ulsan, Ulsan Univ Hosp, Dept Hematol & Oncol, Coll Med, Ulsan, South Korea; Ewha Womans Univ, Sch Med, Dept Hematol & Oncol, Seoul, South Korea; Inje Univ, Dept Hematol & Oncol, Busan Paik Hosp, Busan, South Korea; Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Dept Hematol,Catholic Hematol Hosp, Seoul, South Korea; Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Leukemia Res Inst, Seoul, South Korea | Kim, Dae Sik/HTT-1263-2023; LEE, SOOYEON/KAM-6204-2024; Yi, Jun Ho/GXZ-8144-2022; Lee, Jong-Seok/J-5603-2012 | 55773608600; 55511978300; 8960168300; 55742979100; 56813113800; 56175730000; 56568642700; 24339940900; 7405373234; 56450114900; 35785270600; 35200292800; 7003363716; 55556573100; 27169807700; 8701758000 | drydh1685@hotmail.com; | YONSEI MEDICAL JOURNAL | YONSEI MED J | 0513-5796 | 1976-2437 | 61 | 6 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.759 | 36.2 | 0.16 | 2025-06-25 | 2 | 2 | Fludarabine; busulfan; lymphoblastic leukemia; stem cell transplantation; transplantation conditioning | DISEASE; ADULTS; RISK | Busulfan; Lymphoblastic leukemia; Stem cell transplantation; Transplantation conditioning; Fludarabine | Acute Disease; Adolescent; Adult; Aged; Busulfan; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Kaplan-Meier Estimate; Middle Aged; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proportional Hazards Models; Recurrence; Transplantation Conditioning; Transplantation, Homologous; Vidarabine; Young Adult; busulfan; cyclosporine; fludarabine; granulocyte colony stimulating factor; histone lysine methyltransferase 2a; HLA antigen class 1; lactate dehydrogenase; methotrexate; methyltransferase; pre B cell leukemia transcription factor 1; tacrolimus; thymocyte antibody; transcription factor E2A; unclassified drug; busulfan; fludarabine; vidarabine; acute lymphoblastic leukemia; adult; allogeneic hematopoietic stem cell transplantation; Article; bacteremia; blood cell count; candidiasis; cerebrospinal fluid cytology; Clostridium difficile infection; cytogenetics; cytomegalovirus infection; engraftment syndrome; female; follow up; graft versus host reaction; hemorrhagic cystitis; herpes zoster; human; immunosuppressive treatment; low drug dose; lung mycosis; major clinical study; male; mortality rate; nuclear magnetic resonance imaging; outcome assessment; overall survival; Philadelphia 1 chromosome; recurrence free survival; reduced intensity conditioning; vein occlusion; acute disease; acute lymphoblastic leukemia; adolescent; adverse event; aged; allotransplantation; graft versus host reaction; hematopoietic stem cell transplantation; Kaplan Meier method; middle aged; multivariate analysis; proportional hazards model; recurrent disease; transplantation conditioning; young adult | English | 2020 | 2020-06 | 10.3349/ymj.2020.61.6.452 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Successful Sirolimus Treatment for Korean Patients with Activated Phosphoinositide 3-kinase δ Syndrome 1: the First Case Series in Korea | Activated phosphoinositide 3-kinase delta syndrome (APDS)1 is caused by gain-of-function mutations in PIK3CD, which encodes the catalytic p110 delta subunit of phosphoinositide 3 kinase. We describe three patients with APDS1, the first thereof in Korea. 1 herein, we investigated clinical manifestations of APDS1 and collected data on the efficacy and safety profile of sirolimus, a mammalian target of rapamycin inhibitor and pathway-specific targeted medicine. The same heterozygous PIK3CD mutation was detected in all three patients (E1021K). After genetic diagnosis, all patients received sirolimus and experienced an excellent response, induding amelioration of lymphoproliferation and improvement of nodular mucosal lymphoid hyperplasia in the gastrointestinal tract. The median trough level of sirolimus was 5.5 ng/mL (range, 2.8-7.5) at a dose of 2.6-3.6 mg/m(2). Two patients who needed high-dose, short-interval, inununoglobulin-replacement treatment (IGRT) had a reduced requirement for IGRT after initiating sirolimus, and the dosing interval was extended from 2 and 3 weeks to 4 weeks. The IgG trough level after sirolimus treatment (median, 594 mg/dL; range, 332-799 mg/dL) was significantly higher than that before sirolimus treatment (median, 290 mg/dL; range, 163-346 mg/dL) (p<0.001). One episode of elevated serum creatinine with a surge of sirolimus (Patient 2) and episodes of neutropenia and oral stomatitis (Patient 1) were observed. We diagnosed the first three patients with APDS1 in Korea. Low-dose sirolimus may alleviate clinical manifestations thereof, induding hypogammaglobulinemia. | Kang, Ji-Man; Kim, Su Kyung; Kim, Dongsub; Choi, Sae Rom; Lirn, Yeon Jung; Kim, Soon Ki; Park, Byung-Kiu; Park, Weon Seo; Kang, Eun-Suk; Ko, Young Hyeh; Choe, Yon Ho; Lee, Ji Won; Kim, Yae-Jean | Yonsei Univ, Severance Childrens Hosp, Dept Pediat, Coll Med, Seoul, South Korea; Yonsei Univ, Inst Immunol & Immunol Dis, Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Pediat, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Pediat, Daegu, South Korea; Chungnam Natl Univ, Coll Med, Dept Pediat, Daejeon, South Korea; Inha Univ, Dept Pediat, Med Ctr, Incheon, South Korea; Natl Canc Ctr, Ctr Pediat Canc, Goyang, South Korea; Natl Canc Ctr, Dept Pathol, Goyang, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Lab Med & Genet, Sch Med, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Pathol, Sch Med, Seoul, South Korea | ; LEE, Ji/C-2295-2009; Kim, Sang-Ha/ACC-9085-2022 | 56587136500; 57216988653; 57205248455; 57203744913; 23972945200; 55190025100; 35300225600; 7402229237; 20234715300; 16646069600; 21333712100; 57217265353; 7410198066 | yaejeankim@skku.edu; | YONSEI MEDICAL JOURNAL | YONSEI MED J | 0513-5796 | 1976-2437 | 61 | 6 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.759 | 36.2 | 0.48 | 2025-06-25 | 16 | 15 | Activated phosphoinositide 3-kinase delta syndromel; sirolimus; Korea | Korea; Sirolimus; Activated phosphoinositide 3-kinase delta syndrome1 | Adolescent; Child, Preschool; Class I Phosphatidylinositol 3-Kinases; Female; Humans; Male; Primary Immunodeficiency Diseases; Republic of Korea; Sirolimus; Treatment Outcome; creatinine; immunoglobulin A; immunoglobulin G; phosphatidylinositol 3 kinase; rapamycin; phosphatidylinositol 4,5 bisphosphate 3 kinase; rapamycin; activated phosphoinositide 3 kinase delta syndrome 1; activated phosphoinositide 3 kinase delta syndrome 1; adolescent; Article; bronchiectasis; case report; child; clinical article; common variable immunodeficiency; computer assisted tomography; Cytomegalovirus; cytopenia; drug efficacy; drug safety; female; gain of function mutation; hepatomegaly; human; immune deficiency; immunoglobulin A deficiency; immunotherapy; lung infiltrate; lymphadenopathy; lymphoid hyperplasia; male; neutropenia; osteomyelitis; positron emission tomography; preschool child; rectum hemorrhage; Sanger sequencing; splenomegaly; stomatitis; tonsillitis; drug therapy; immunology; pathology; South Korea; treatment outcome | English | 2020 | 2020-06 | 10.3349/ymj.2020.61.6.542 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Survival Trend of HIV/AIDS Patients Starting Antiretroviral Therapy in South Korea between 2001 and 2015 | Purpose: In the recent antiretroviral therapy (ART) era, a large proportion of Korean patients with human immunodeficiency virus (HIV) infection were shown to have low CD4 cell counts at diagnosis and during ART initiation. We investigated the survival trends in patients living with HIV/acquired immunodeficiency syndrome (AIDS) in Korea who started ART in the 2000s, and evaluated the risk factors for mortality to elucidate the association between survival and low CD4 cell counts at ART initiation. Materials and Methods: Patients with HIV infection who were aged >18 years and had started ART between 2001 and 2015 in the Korean HIV/AIDS cohort study were enrolled. We compared the clinical characteristics, mortality, and causes of death among the enrolled subjects based on the time of ART initiation. Cox regression analysis was used to estimate the adjusted hazard ratios of mortality based on the time of ART initiation. Results: Among the 2474 patients enrolled, 105 (4.24%) died during the follow-up period of 9568 patient-years. Although CD4 cell counts at the time of ART initiation significantly increased from 161 [interquartile range (IQR), 73.5-303] in 2001-2003 to 273 (IQR, 108-399) in 2013-2015 (p40 years [adjusted hazard ratio, 3.71; 95% confidence interval (CI), 2.35-5.84] and low CD4 counts (<100 cells/mm(3): adjusted hazard ratio, 2.99; 95% CI, 1.44-6.23) were significant risk factors for mortality. Conclusion: Despite excellent HIV care available in the recent ART era, the survival of patients with HIV/AIDS undergoing ART did not improve between 2001 and 2015 in Korea. | Kim, Yong Chan; Ahn, Jin Young; Kim, Hyo Youl; Song, Joon Young; Park, Dae Won; Kim, Min Ja; Choi, Hee-Jung; Kim, Shin Woo; Kee, Mee-Kyung; Han, Myung Guk; Yoo, Myeongsu; Kim, Soo Min; Choi, Yunsu; Choi, Bo Youl; Kim, Sang Il; Choi, Jun Yong | Yonsei Univ, Gangnam Severance Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea; Yonsei Univ, AIDS Res Inst, Coll Med, Seoul, South Korea; Yonsei Univ, Dept Internal Med, Wonju Coll Med, Wonju, South Korea; Korea Univ, Dept Internal Med, Div Infect Dis, Coll Med, Seoul, South Korea; Ewha Womans Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Korea Natl Inst Hlth, Ctr Infect Dis Res, Div Viral Dis Res, Cheongju, South Korea; Hanyang Univ, Inst Hlth & Soc, Seoul, South Korea; Hanyang Univ, Dept Prevent Med, Coll Med, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Div Infect Dis,Dept Internal Med, Seoul, South Korea | Choi, Jah/AAA-4835-2022; Kim, Yong-Tae/HQZ-0240-2023; Kim, Sun/G-3451-2013; Kim, Ji Hwan/JKJ-3785-2023; Choi, Yunsu/AAH-1260-2021; Kim, Sooyeon/AAA-8521-2022; Kim, Sara/F-2951-2013 | 36486497700; 55241325500; 56819456800; 57214400146; 55724785200; 35278323100; 57217262202; 8710731500; 8212011900; 47161240000; 57211186635; 57194701617; 57195931031; 55663343300; 56941143600; 57791298700 | seran@yuhs.ac; | YONSEI MEDICAL JOURNAL | YONSEI MED J | 0513-5796 | 1976-2437 | 61 | 8 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.759 | 36.2 | 0.08 | 2025-06-25 | 7 | 5 | Anti-retroviral agents; HIV; Republic of Korea; survival | LATE DIAGNOSIS; HIV-INFECTION; LIFE EXPECTANCY; AIDS; DEATH; COHORT; IMPACT; MORTALITY; DISEASE; PEOPLE | HIV; Republic of Korea; Survival; Anti-retroviral agents | Acquired Immunodeficiency Syndrome; Adult; Antiretroviral Therapy, Highly Active; Cause of Death; CD4 Lymphocyte Count; Cohort Studies; Female; Humans; Male; Middle Aged; Proportional Hazards Models; Republic of Korea; Risk Factors; Survival Analysis; antiretrovirus agent; acquired immune deficiency syndrome; acute kidney failure; adult; antiretroviral therapy; Article; cardiovascular disease; cause of death; CD4 lymphocyte count; cohort analysis; drug combination; female; follow up; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; infection; leiomyomatosis; liver disease; major clinical study; male; malignant neoplasm; middle aged; monotherapy; mortality; mortality rate; patient care; patient compliance; proportional hazards model; questionnaire; respiratory tract disease; retrospective study; risk factor; South Korea; survival; virus load; Western blotting; acquired immune deficiency syndrome; epidemiology; highly active antiretroviral therapy; survival analysis | English | 2020 | 2020-08 | 10.3349/ymj.2020.61.8.705 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Use of Darunavir-Cobicistat as a Treatment Option for Critically Ill Patients with SARS-CoV-2 Infection | We retrospectively reviewed patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections who were admitted to an intensive care unit in Daegu, South Korea. The outcomes of patients who did (cases) or did not (controls) receive darunavir-cobicistat (800-150 mg) therapy were compared. Fourteen patients received darunavir-cobicistat treatment, and 96 received other antiviral therapy (controls). Overall, the darunavir-cobicistat group comprised patients with milder illness, and the crude mortality rate of all patients in the darunavir-cobicistat group was lower than that in the controls [odds ratio (OR) 0.20, 95% confidence interval (CI) 0.04-0.89, p.0.034 After 1:2 propensity-score matching, there were 14 patients in the darunavir-cobicistet group, and 28 patients in the controls. In propensity score-matched analysis, the darunavir-cobicistat group had lower mortality than the controls (OR 0.07, 95% CI 0.01-0.52, p=0.009). In conclusion, darunavir-cobicistat therapy was found to be associated with a significant survival benefit in critically ill patients with SARS-CoV-2 infection. | Kim, Eun Jin; Choi, Sun Ha; Park, Jae Seok; Kwon, Yong Shik; Lee, Jaehee; Kim, Yeonjae; Lee, Shin Yup; Choi, Eun Young | Daegu Catholic Univ, Div Pulm & Crit Care Med, Med Ctr, Daegu, South Korea; Kyungpook Natl Univ, Div Pulm & Crit Care Med, Chilgok Hosp, Daegu, South Korea; Keimyung Univ, Dongsan Hosp, Dept Internal Med, Div Pulmonol,Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Daegu Fatima Hosp, Div Pulm & Crit Care Med, Daegu, South Korea; Yeungnam Univ, Div Pulm & Crit Care Med, Med Ctr, 170 Hyeonchung Ro, Daegu 42415, South Korea | Lee, Yoojin/AAB-9799-2022; Kim, Eun Jin/L-6480-2018; Lee, Jaehee/S-1697-2018; Kim, Eun/AAS-6706-2020; Choi, Sun Ha/HPD-7234-2023 | 55927957400; 57199723585; 8866846500; 57203804743; 13805476000; 56066688300; 49863712700; 57190418295 | letact@yu.ac.kr; | YONSEI MEDICAL JOURNAL | YONSEI MED J | 0513-5796 | 1976-2437 | 61 | 9 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.759 | 36.2 | 0.64 | 2025-06-25 | 10 | 11 | Coronavirus disease 2019; severe acute respiratory syndrome coronavirus 2; darunavir-cobicistat | Coronavirus disease 2019; Darunavir-cobicistat; Severe acute respiratory syndrome coronavirus 2 | Adult; Anti-HIV Agents; Betacoronavirus; Case-Control Studies; Cobicistat; Coronavirus Infections; Critical Illness; Darunavir; Female; HIV Protease Inhibitors; Humans; Intensive Care Units; Male; Middle Aged; Pandemics; Pneumonia, Viral; Republic of Korea; Retrospective Studies; Severity of Illness Index; Treatment Outcome; cobicistat plus darunavir; anti human immunodeficiency virus agent; cobicistat; darunavir; Human immunodeficiency virus proteinase inhibitor; adult; adult respiratory distress syndrome; aged; antiretroviral therapy; antiviral therapy; APACHE; Article; artificial ventilation; case control study; controlled study; coronavirus disease 2019; critically ill patient; female; hospitalization; human; intensive care unit; major clinical study; male; mortality rate; propensity score; real time reverse transcription polymerase chain reaction; retrospective study; risk factor; Sequential Organ Failure Assessment Score; Severe acute respiratory syndrome coronavirus 2; Betacoronavirus; Coronavirus infection; critical illness; epidemiology; middle aged; mortality; pandemic; severity of illness index; South Korea; treatment outcome; virus pneumonia | English | 2020 | 2020-09 | 10.3349/ymj.2020.61.9.826 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Fluoroscopic images-based aiming and targeting system with two line lasers for insertion guidance of interlocking screw | Purpose Minimally invasive surgery is widely used for managing fractures; however, it is difficult to determine the exact screwing position of intramedullary nails inserted into bone. To address this problem, we developed the aiming and targeting system by laser (ATLAS) using two line lasers to mark the position of the surgical tool directly on the skin. Methods ATLAS consists of a laser module, controller, personal computer, and display device. The laser module is fixed to the intensifier side of the C-arm. Calibration with dedicated markers is required prior to using the system. After calibration, the laser modules can mark the selected point on a fluoroscopic image acquired with the C-arm as the intersection of the two line lasers on the skin. Results To verify the effectiveness of ATLAS, marking accuracy was measured. The average control error of the device itself was 0.57 mm. In the experimental setting using C-arm fluoroscopy, the accuracy was within 1.5 mm at 23 of the 25 measurement points and within 3 mm at the remaining two points. Conclusion ATLAS shows the corresponding points in real space with respect to fluoroscopic images using cross-points of lasers. The proposed method is clinically useful to aid the insertion of interlocking screws in minimally invasive surgeries for bone fractures. We believe that ATLAS enables more accurate marking through C-arm fluoroscopy and is more convenient, and it can thus be applied in various orthopedic surgeries. | Yu, Jihun; Song, Hoseob; Park, Chul-woo; Park, Ilhyung; Joung, Sanghyun | Kyungpook Natl Univ, Med Device & Robot Inst Pk MDRIP, Global Plaza 1006,80 Daehak Ro, Daegu, South Korea; WECAN Solut Inc, 71,Yulhadong Ro 8 Gil, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Orthoped Surg, 680 Gukchaebosang Ro, Daegu, South Korea | 57216926626; 57216924457; 23995581000; 35076285100; 14628748500 | shjoung@mdrip.knu.ac.kr; | INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY | INT J COMPUT ASS RAD | 1861-6410 | 1861-6429 | 15 | 6 | SCIE | ENGINEERING, BIOMEDICAL;RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING;SURGERY | 2020 | 2.924 | 36.3 | 0.08 | 2025-06-25 | 4 | 2 | Laser guidance; Minimally invasive surgery; C-arm fluoroscopy; Radiation exposure; Intramedullary nail | DISTAL LOCKING; INTRAMEDULLARY NAILS; NAVIGATION | C-arm fluoroscopy; Intramedullary nail; Laser guidance; Minimally invasive surgery; Radiation exposure | Fluoroscopy; Fracture Fixation, Intramedullary; Fractures, Bone; Humans; Lasers; Minimally Invasive Surgical Procedures; Surgery, Computer-Assisted; Article; fluoroscopy; image analysis; priority journal; computer assisted surgery; fluoroscopy; fracture; human; intramedullary nailing; laser; minimally invasive surgery; procedures | English | 2020 | 2020-06 | 10.1007/s11548-020-02196-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Generative approach for data augmentation for deep learning-based bone surface segmentation from ultrasound images | Purpose Precise localization of cystic bone lesions is crucial for osteolytic bone tumor surgery. Recently, there is a move toward ultrasound imaging over plain radiographs (X-rays) for intra-operative navigation due to the radiation-free and cost-effectiveness of the modality. In this process, the intra-operative bone model reconstructed from the segmented ultrasound image is registered with the pre-operative bone model. Deep learning approaches have recently shown remarkable success in bone surface segmentation from ultrasound images. However, to train deep learning models effectively with limited dataset size, data augmentation is essential. This study investigates the applicability of the generative approach for data augmentation as well as identifies standard data augmentation approaches for bone surface segmentation from ultrasound images. Methods The generative approach we used in our work is based on Pix2Pix image-to-image translation network. We have proposed a multiple-snapshot approach, which mitigates the uni-modal deterministic output issue in the Pix2Pix network without using any complex architecture and training process. We also identified standard data augmentation approaches necessary for ultrasound bone surface segmentation through experiments. Results We have evaluated our networks using 800 ultrasound images from trained regions (humerus bone) and 1200 ultrasound images from untrained regions (tibia and femur bones) using four different augmentation approaches. The results show that the generative augmentation approach has a positive impact on accuracy in both trained (+ 4.88%) and untrained regions (+ 25.84%) compared to using only standard augmentations. Moreover, compared to standard augmentation approaches, the addition of the generative augmentation approach also showed a similar trend in both trained (+ 8.74%) and untrained (+ 11.55%) regions. Conclusion Generative approaches are very beneficial for data augmentation, where limited dataset size is prevalent, such as ultrasound bone segmentation. The proposed multiple-snapshot Pix2Pix approach has the potential to generate multimodal images, which enlarges the dataset considerably. | Zama, Asaduz; Park, Sang Hyun; Bang, Hyunhee; Park, Chul-woo; Park, Ilhyung; Joung, Sanghyun | Kyungpook Natl Univ, MDRIP, Daegu, South Korea; Daegu Gyungbuk Inst Sci & Technol, Robot Engn, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Orthoped, Daegu, South Korea | 57703073600; 57188954175; 57216785452; 23995581000; 35076285100; 14628748500 | shjoung@mdrip.knu.ac.kr; | INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY | INT J COMPUT ASS RAD | 1861-6410 | 1861-6429 | 15 | 6 | SCIE | ENGINEERING, BIOMEDICAL;RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING;SURGERY | 2020 | 2.924 | 36.3 | 1.73 | 2025-06-25 | 28 | 34 | Ultrasound bone segmentation; Deep learning; GAN; Pix2Pix; Augmentation; Osteolytic bone tumor surgery; Cystic bone lesion | Augmentation; Cystic bone lesion; Deep learning; GAN; Osteolytic bone tumor surgery; Pix2Pix; Ultrasound bone segmentation | Bone Neoplasms; Deep Learning; Femur; Humans; Humerus; Image Processing, Computer-Assisted; Tibia; Ultrasonography; Article; automation; bone microarchitecture; bone surface density; contrast enhancement; controlled study; deep learning; echography; female; human; human experiment; image segmentation; male; normal human; peroperative care; priority journal; radiation attenuation; bone tumor; diagnostic imaging; echography; femur; humerus; image processing; procedures; tibia | English | 2020 | 2020-06 | 10.1007/s11548-020-02192-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Estimation of gamma-rays, and fast and the thermal neutrons attenuation characteristics for bismuth tellurite and bismuth boro-tellurite glass systems | Gamma-rays and fast and thermal neutron attenuation features of (Bi2O3)(x)-(TeO2)((100-x)) (where x = 5, 8, 10, 12, and 15 mol%) and [(TeO2)(0.7)-(B2O3)(0.3)]((1-x))-(Bi2O3)(x) (where x = 0.05, 0.10, 0,15, 0.20, 0.25, and 0.3 mol%) glass systems have been explored and compared. For all samples, mass attenuation coefficients (mu/rho) are estimated within 0.015-15 MeV photon energy range by MCNP5 simulation code and correlated with WinXCom results, which showed a satisfactory agreement between computed mu/rho values by these both methods. Additionally, effective atomic number (Z(eff)), effective electron density (N-eff), half-value layer (HVL), tenth-value layer (TVL), mean free path (MFP), total atomic cross-section (sigma(a)), and total electronic cross-section (sigma(e)) are calculated by utilizing mu/rho values. The mu/rho, Z(eff), and N-eff are energy dependent and have higher values at the lowest energy and smaller values at higher energies. Moreover, using the G-P fitting method as a function of penetration depth (up to 40 mfp) and incident photon energy (0.015-15 MeV range), exposure buildup factors (EBFs) and energy absorption buildup factors (EABFs) are evaluated. Both 85TeO(2)-15Bi(2)O(3) (mol%) and 49TeO(2)-21B(2)O(3)-30Bi(2)O(3) (mol%) samples, by possessing higher values of Z(eff), exhibit minimum EBF and EABF values. Highest mu/rho, Z(eff) values and lowest HVL, TVL, MFP values of 49TeO(2)-21B(2)O(3)-30Bi(2)O(3) (mol%) sample indicated its better gamma-ray absorption capability among all selected glasses. Further, macroscopic effective removal cross-section for fast neutrons (sigma(R)), coherent scattering cross-section (sigma(cs)), incoherent scattering cross-section (sigma(ics)), absorption cross-section (sigma(A)), and total cross-section (sigma(T)) values for thermal neutron attenuation have been computed. Among all samples, 49TeO(2)-21B(2)O(3)-30Bi(2)O(3) (mol%) glass possesses a better sigma(R) value for fast neutron attenuation, while the largest 'sigma(T)' value of 66.5TeO(2)-28.5B(2)O(3)-5Bi(2)O(3) (mol%) sample suggests its good thermal neutron absorption efficiency. | Lakshminarayana, G.; Kebaili, Imen; Dong, M. G.; Al-Buriahi, M. S.; Dahshan, A.; Kityk, I., V; Lee, Dong-Eun; Yoon, Jonghun; Park, Taejoon | Kyungpook Natl Univ, Intelligent Construct Automat Ctr, 80 Daehak Ro, Daegu 41566, South Korea; King Khalid Univ, Fac Sci, Dept Phys, POB 9004, Abha, Saudi Arabia; Univ Sfax, Fac Sci Sfax, Dept Phys, Grp Phys Mat Luminescents,Lab Phys Appl, BP 1171, Sfax 3018, Tunisia; Northeastern Univ, Dept Resource & Environm, Shenyang 110819, Peoples R China; Sakarya Univ, Dept Phys, Sakarya, Turkey; Port Said Univ, Fac Sci, Dept Phys, Port Said, Egypt; Czestochowa Tech Univ, Fac Elect Engn, Inst Optoelect & Measuring Syst, 17 Armii Krajowej Str, PL-42200 Czestochowa, Poland; Kyungpook Natl Univ, Sch Architecture & Civil Engn, 80 Daehak Ro, Daegu 41566, South Korea; Hanyang Univ, Dept Mech Engn, 55 Hanyangdaehak Ro, Ansan 15588, Gyeonggi Do, South Korea; Hanyang Univ, Dept Robot Engn, 55 Hanyangdaehak Ro, Ansan 15588, Gyeonggi Do, South Korea | DONG, Mengge/AEN-2933-2022; Kebaili, Imen/AIC-9446-2022; Al-Buriahi, M.S./HKW-2385-2023; Kityk, Andriy/B-8351-2008; Dahshan, Alaa/AHE-5362-2022; Gandham, Lakshminarayana/AAU-6162-2020 | 57194637883; 37107670200; 56082379700; 57191693608; 6602133954; 7102138516; 56605563300; 56449838900; 55717001200 | gandham@knu.ac.kr;dolee@knu.ac.kr;yooncsmd@gmail.com;taejoon@hanyang.ac.kr; | JOURNAL OF MATERIALS SCIENCE | J MATER SCI | 0022-2461 | 1573-4803 | 55 | 14 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2020 | 4.22 | 36.4 | 4.53 | 2025-06-25 | 76 | 81 | RADIATION SHIELDING PROPERTIES; BORATE GLASSES; LEAD BORATE; FEATURES; PHOTON; OXIDE; PROGRAM; BARIUM | Atoms; Bismuth compounds; Coherent scattering; Glass; Incoherent scattering; Neutrons; Photons; Tellurium compounds; Absorption cross sections; Attenuation characteristics; Effective electron densities; Electronic cross sections; Energy absorption buildup factors; Incoherent scattering cross sections; Mass attenuation coefficients; Scattering cross section; Gamma rays | English | 2020 | 2020-05 | 10.1007/s10853-020-04446-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Graphene oxide-embedded chitosan/gelatin hydrogel particles for the adsorptions of multiple heavy metal ions | Spherical-shaped graphene oxide-embedded chitosan/gelatin hydrogel particles (CGGO) were prepared by using inverse suspension method from biopolymers chitosan and gelatin with graphene oxide for the adsorption of heavy metal ions (HM). The prepared CGGO particles were characterized by various physicochemical techniques such as field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy analysis, X-ray diffraction, and Fourier transform infrared spectrometry. HM-Pb(II), Cd(II), Hg(II), and Cr(III) adsorption experiments using CGGO showed 55% removal efficiency of Hg(II) in the single metal system. However, in the multiple metal ion system, all metal ions showed removal efficiency > 70%. This suggests that the prepared hydrogel particles can be effectively used for the removal of HM. The preparation method also paves the way for the large-scale production of hydrogel particles as HM adsorbents. | Perumal, Suguna; Atchudan, Raji; Yoon, Dong Ho; Joo, Jin; Cheong, In Woo | Kyungpook Natl Univ, Sch Engn, Dept Appl Chem, Daehak Ro 80, Daegu 41566, South Korea; Yeungnam Univ, Sch Chem Engn, Gyongsan 38541, South Korea; Kuk Il Paper Mfg Co Ltd, R&D Ctr, Baekok Daero 563, Yongin 17128, South Korea | perumal, suguna/N-9075-2017; RAJI, ATCHUDAN/C-9904-2017 | 56673798900; 26648054700; 57205212303; 57189617034; 7006733373 | joojin@knu.ac.kr;inwoo@knu.ac.kr; | JOURNAL OF MATERIALS SCIENCE | J MATER SCI | 0022-2461 | 1573-4803 | 55 | 22 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2020 | 4.22 | 36.4 | 2.32 | 2025-06-25 | 45 | 50 | EFFICIENT REMOVAL; WASTE-WATER; CD(II); HG(II) | Cadmium Compounds; Chitosan; Chromium Compounds; Heavy Metals; Lead Compounds; Scanning Electron Microscopy; Biopolymers; Cadmium compounds; Chitosan; Chromium compounds; Energy dispersive spectroscopy; Field emission microscopes; Fourier transform infrared spectroscopy; Graphene; Heavy metals; Hydrogels; Inverse problems; Lead compounds; Metal ions; Scanning electron microscopy; Suspensions (fluids); Adsorption experiment; Energy dispersive x-ray spectroscopy analysis; Field emission scanning electron microscopy; Fourier transform infrared spectrometry; Large scale productions; Physicochemical techniques; Removal efficiencies; Suspension methods; Mercury compounds | English | 2020 | 2020-08 | 10.1007/s10853-020-04651-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Computation of Molecular Electron Affinities Using an Ensemble Density Functional Theory Method | The computation of electron attachment energies (electron affinities) was implemented in connection with an ensemble density functional theory method, the state-interaction state-averaged spin-restricted ensemble-referenced Kohn-Sham (SI-SA-REKS or SSR) method. With the use of the extended Koopmans' theorem, the electron affinities and the respective Dyson orbitals are obtained directly for the neutral molecule, thus avoiding the necessity to compute the ionized system. Together with the EKT-SSR (extended Koopmans' theorem-SSR) method for ionization potentials, which was developed earlier, EKT-SSR for electron affinities completes the implementation of the EKT-SSR formalism, which can now be used for obtaining electron detachment as well as the electron attachment energies of molecules in the ground and excited electronic states. The extended EKT-SSR method was tested in the calculation of several closed-shell molecules. For the molecules in the ground states, the EKT-SSR energies of Dyson's orbitals are virtually identical to the energies of the unoccupied orbitals in the usual single-reference spin-restricted Kohn-Sham calculations. For the molecules in the excited states, EKT-SSR predicts an increase of the most positive electron affinity by approximately the amount of the vertical excitation energy. The electron affinities of a number of diradicals were calculated with EKT-SSR and compared with the available experimental data. With the use of a standard density functional (BH&HLYP), the EKT-SSR electron affinities deviate on average by ca. 0.2 eV from the experimental data. It is expected that the agreement with the experiment can be improved by designing density functionals parametrized for ionization energies. | Filatov, Michael; Lee, Seunghoon; Nakata, Hiroya; Choi, Cheol Ho | Kyungpook Natl Univ, Dept Chem, Daegu 702701, South Korea; CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA; R&D Ctr Kagoshima, Kagoshima 8994312, Japan | ; Nakata, Hiroya/V-3205-2018; Choi, Cheol Ho/AAA-4705-2020; Lee, Seunghoon/AAB-4846-2021 | 7005134246; 57194591254; 55305767500; 7402958948 | mike.filatov@gmail.com;cheolho.choi@gmail.com; | JOURNAL OF PHYSICAL CHEMISTRY A | J PHYS CHEM A | 1089-5639 | 1520-5215 | 124 | 38 | SCIE | CHEMISTRY, PHYSICAL;PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | 2020 | 2.781 | 36.5 | 0.81 | 2025-06-25 | 15 | 15 | RESOLVED PHOTOELECTRON-SPECTROSCOPY; REFERENCED KOHN-SHAM; FRACTIONALLY OCCUPIED STATES; IONIZATION-POTENTIALS; KOOPMANS THEOREM; EXCITED-STATES; M-BENZYNE; MOUNTAINEERING STRATEGY; PROPAGATOR THEORY; WAVE-FUNCTIONS | Computation theory; Density functional theory; Electrons; Ground state; Ionization potential; Molecules; Density functional theory methods; Density functionals; Electron attachment; Electron detachments; Excited electronic state; Kohn-Sham calculations; Neutral molecules; Vertical excitation energy; article; density functional theory; excitation; ionization; Electron affinity | English | 2020 | 2020-09-24 | 10.1021/acs.jpca.0c06976 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Development of evaluation methods and determination of hardness variation with leaf order and tissue type of Kimchi cabbage during summer harvest | The texture of Kimchi cabbage was investigated by determining the hardness variation of midribs by leaf order and midrib position and analyzing the hardness characteristic by probe type. The objective of this research was the development of assessment methods for hardness of Kimchi cabbages in cropping types of summer season production. The hardness of the midrib of Kimchi cabbage leaves varied depending on the degree of development of the internal and external epidermis and the vascular tissues. The midrib hardness of Kimchi cabbage leaves did not differ significantly among cultivation types and tended to be lower toward the inner leaf. Using the Volodkevich bite jaws probe or blade set probe to measure the cutting force proved to be a suitable approach for examining the texture characteristic of Kimchi cabbage. The peak force of hardness in volodkevich bite jaw probe test the smallest distance and the second and third peak force intervals distance showed shortest among all the tested probes. In addition, hardness force tests with inside and outside results pattern was similar. When measuring the cutting force of midrib by these probes, it is preferable to measure from the outer epidermis to the inner epidermis of the leaf midrib, at 40-50 mm from the leaf stalk, on the 2nd to 6th outer leaves of Kimchi cabbage head formation. | Kim, Ki-Deog; Suh, Jong-Taek; Lee, Jong-Nam; Yoo, Dong-Lim; Nam, Jung-Hwan; Sohn, Hwang-Bae; Hong, Su-Young; Kim, Yul-Ho; Kim, Su-Jeong; Hong, Soon-Choon; Kim, Sung Kyeom | RDA, Natl Inst Crop Sci, Highland Agr Res Inst, Pyeongchang 25342, South Korea; Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Hort Sci, Daegu 41566, South Korea | Kim, Jung/JAO-0332-2023; Kim, Sung Kyeom/AAD-9230-2019 | 56651226400; 56806158100; 56651301300; 56651748300; 8526985700; 56651720700; 57204646237; 37084899500; 57197724006; 57189064097; 50262290200 | skkim76@knu.ac.kr; | HORTICULTURE ENVIRONMENT AND BIOTECHNOLOGY | HORTIC ENVIRON BIOTE | 2211-3452 | 2211-3460 | 61 | 5 | SCIE | HORTICULTURE | 2020 | 1.842 | 36.5 | 0.2 | 2025-06-25 | 4 | 4 | Cutting force; Force-distance curve; Highland; Midrib thickness; Texture | Cutting force; Force–distance curve; Highland; Midrib thickness; Texture | English | 2020 | 2020-10 | 10.1007/s13580-020-00266-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Diboron- and Diaza-Doped Anthracenes and Phenanthrenes: Their Electronic Structures for Being Singlet Fission Chromophores | We used quantum chemistry methods at the levels of mixed-reference spin-flip time-dependent density functional theory and multireference perturbation theory to study diboronand diaza-doped anthracenes and phenanthrenes. This class of structures recently surged as potential singlet fission chromophores. We studied electronic structures of their excited states and clarified the reasons why they satisfy or fail to satisfy the energy criteria for singlet fission chromophores. Many studied structures have their S-1 states not dominated by HOMO -> LUMO excitation, so they cannot be described using the conventional two site model. This is attributed to frontier orbital energy shifts induced by the doping and different charge-transfer energies in different one-electron singlet excitations or, in other words, different polarizations of hole and/or particle orbitals in their S-1 and T-1 states. There is a mirror relation between the orbital energy shifts induced by diboron- and diaza-dopings, which together with alternant hydrocarbon pairings of occupied and unoccupied orbitals, leads to more mirror relations between the excited states of the two types of doped structures. | Pradhan, Ekadashi; Lee, Seunghoon; Choi, Cheol Ho; Zeng, Tao | York Univ, Dept Chem, Toronto, ON M3J 1P3, Canada; CALTECH, Div Chem & Chem Eng, Pasadena, CA 91125 USA; Kyungpook Natl Univ, Dept Chem, Daegu 702701, South Korea | ; Lee, Seunghoon/AAB-4846-2021; Choi, Cheol Ho/AAA-4705-2020; Zeng, Tao/D-1284-2017 | 36718038700; 57194591254; 7402958948; 55357898600 | tzeng@yorku.ca; | JOURNAL OF PHYSICAL CHEMISTRY A | J PHYS CHEM A | 1089-5639 | 1520-5215 | 124 | 40 | SCIE | CHEMISTRY, PHYSICAL;PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | 2020 | 2.781 | 36.5 | 1.47 | 2025-06-25 | 33 | 33 | DEGENERATE PERTURBATION-THEORY; DIRADICAL-CHARACTER; MOLECULAR DESIGN; EFFICIENT IMPLEMENTATION; THIN-FILM; STATES; PENTACENE; HYDROCARBONS; SPECTROSCOPY; MECHANISM | Anthracene; Charge transfer; Density functional theory; Electronic structure; Excited states; Mirrors; Perturbation techniques; Quantum chemistry; Singlet fission; Charge transfer energy; Doped structures; Energy criterion; Frontier orbital energies; Multi reference; Orbital energy; Perturbation theory; Quantum chemistry methods; Chromophores | English | 2020 | 2020-10-08 | 10.1021/acs.jpca.0c06915 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Correction | Foliar application of biostimulants affects physiological responses and improves heat stress tolerance in Kimchi cabbage (vol 60, pg 841, 2020) | The original version of this article unfortunately contained a mistake. | Lee, Hee Ju; Lee, Jin Hyoung; Lee, Sang Gyu; An, Sewoong; Lee, Hee Su; Choi, Chang Keun; Kim, Sung Kyeom | Natl Inst Hort & Herbal Sci, Vegetable Res Div, Wonju 55365, South Korea; Natl Inst Agr Sci, Div Smartfarm Dev, Jeonju 54875, South Korea; Kyungpook Natl Univ, Dept Hort Sci, Daegu 41556, South Korea | ; Kim, Sung Kyeom/AAD-9230-2019 | 59106640900; 48461594400; 50262307100; 57211403160; 51863925300; 59623419400; 50262290200 | skkim76@knu.ac.kr; | HORTICULTURE ENVIRONMENT AND BIOTECHNOLOGY | HORTIC ENVIRON BIOTE | 2211-3452 | 2211-3460 | 61 | 1 | SCIE | HORTICULTURE | 2020 | 1.842 | 36.5 | 11.34 | 2025-06-25 | 3 | 7 | English | 2020 | 2020-02 | 10.1007/s13580-019-00199-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Investigation of the morphological and cytogenetic variations of an intraspecific Asiatic lily hybrid using 5S and 18S rDNA probes | This study aimed to determine the morphological and cytogenetic differences in an intraspecific Asiatic F(1)Lilium hybrid. The results indicated that leaf color and shape, flower morphology including color, spot size on petal, and filament color in the F-1 hybrid showed significant variations as compared to parents, while days to flowering were similar to those of the parents. Moreover, stem height, leaf number, and leaf width showed distinct variations. Interestingly, the intraspecific F-1 progeny obtained from Asiatic lily parents showed higher pollen viability. In addition, FISH results revealed significant variation in the number of 18S rDNA and 5S rDNA loci identified in both parents and the F-1 progeny. The female (2n = 4x = 48) parent had 12 loci of 18S rDNA, whereas the male (2n = 2x = 24) parent and the F-1 (2n = 3x = 36) had 8 and 11 loci of 18S rDNA, respectively. Moreover, the F-1 progeny had 9 loci of 5S rDNA compared with the 7 and 4 loci identified in the female and male parents, respectively. All 5S rDNA signals were observed on the long arm in both the female parent and the F-1; however, one 5S rDNA signal was observed on the short arm in the male parent. Therefore, this study demonstrated that the distribution of ribosomal DNA was greatly different in the F-1 progeny than that of parents. | Islam, Md Mazharul; Yesmin, Reshma; Jung, Min-Jung; Kim, Hong-Yul; Kim, Chang-Kil; Lim, Ki-Byung | Kyungpook Natl Univ, Dept Hort Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea | Islam, Md Mazharul/AFS-6460-2022; Islam, Mazharul/AFS-6460-2022 | 57219091958; 57216450296; 57216450075; 56941037200; 7409880701; 7403175915 | kblim@knu.ac.kr; | HORTICULTURE ENVIRONMENT AND BIOTECHNOLOGY | HORTIC ENVIRON BIOTE | 2211-3452 | 2211-3460 | 61 | 2 | SCIE | HORTICULTURE | 2020 | 1.842 | 36.5 | 0.89 | 2025-06-25 | 9 | 9 | F-1 progeny; FISH; Loci; Lilium; Morphology | IN-SITU HYBRIDIZATION; FISH KARYOTYPE ANALYSIS; LILIUM-RUBELLUM; F-1 HYBRIDS; LONGIFLORUM; SEQUENCES; GISH; POLYPLOIDIZATION; CHROMOSOMES | F<sub>1</sub> progeny; FISH; Lilium; Loci; Morphology | English | 2020 | 2020-04 | 10.1007/s13580-019-00216-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | mHealth Family Adaptation Intervention for Families of Young Children with Down Syndrome: A Feasibility Study | Purpose: The aim of this study was to explore the feasibility of using the mHealth Family Adaptation Intervention (FamilyAdapt-DS), with families of young children with Down syndrome (DS), and to assess the effect of participating in this mHealth intervention on family adaptation. Design and methods: A one-group pre-test post-test design was employed. Sixteen parents from eight families of young children with DS (under the age of three years) participated in this study between September 2015 and September 2016. A Wilcoxon signed rank test was used to identify the difference between the pre-test and post-test scores. Results: All parents perceived that the program was feasible to use and they were willing to recommend the intervention to other families. Improvements were noted between pre-test and post-test scores. For fathers, views of their child's daily life became more positive, their child's condition became more manageable, their problem-solving communication became more affirming and their family functioning scores improved. Mothers reported less difficulty managing their child's condition. Conclusions: These findings suggest that FamilyAdapt-DS is a feasible m-Health intervention for families of young children with DS; however, scaling up of this program with larger and more diverse samples is needed to test its effectiveness. Practice implications: Nurses and other healthcare providers may find it helpful to use therapeutic conversations and mHealth interventions such as the one described in this paper to tailor the care they provide to families of young children with DS. (C) 2019 Elsevier Inc. All rights reserved. | Choi, Hyunkyung; Van Riper, Marcia | Kyungpook Natl Univ, Coll Nursing, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Nursing Sci, Daegu, South Korea; Univ North Carolina Chapel Hill, Sch Nursing, Chapel Hill, NC USA | Choi, Hyunkyung/AAB-4461-2022; Van Riper, Marcia/AAH-5409-2020 | 55619940700; 6603600339 | hchoi@knu.ac.kr; | JOURNAL OF PEDIATRIC NURSING-NURSING CARE OF CHILDREN & FAMILIES | J PEDIATR NURS | 0882-5963 | 50 | SCIE;SSCI | NURSING;PEDIATRICS | 2020 | 2.145 | 36.5 | 1.85 | 2025-06-25 | 13 | 14 | Adaptation; Down syndrome; Family; Mobile health; Nurse | MOTHERS; CARE; RESILIENCE; EXPERIENCE; MANAGEMENT; CAREGIVERS; LIFE | Adaptation; Down syndrome; Family; Mobile health; Nurse | Adaptation, Psychological; Adult; Child, Preschool; Down Syndrome; Fathers; Feasibility Studies; Female; Humans; Infant; Infant, Newborn; Male; Middle Aged; Mothers; Parents; Republic of Korea; Surveys and Questionnaires; Telemedicine; adult; child parent relation; coping behavior; Down syndrome; father; feasibility study; female; human; infant; male; middle aged; mother; newborn; preschool child; procedures; psychology; questionnaire; South Korea; telemedicine | English | 2020 | 2020 (JAN-FEB) | 10.1016/j.pedn.2019.03.010 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Review | Molecular cytogenetics and its application to major flowering ornamental crops | Cytogenetic research can provide valuable information regarding breeding, genetics, bioinformatics, genomics, and the taxonomy of plants. Every year, new varieties of flowering ornamental crops are being produced all over the world. In order to perform efficient breeding, chromosome studies are first conducted. The data obtained from these studies lead to a systematic and less costly crossbreeding. Various techniques, such as FISH (Fluorescent in situ Hybridization) and GISH (Genomic in situ Hybridization), have been used for cytogenetic studies. These methods are used for the identification of ploidy level, construction of an accurate karyotype, and evaluation of hybridity in ornamental crops. Major flowering ornamental crops are economically important for use as cut flowers or as potted plants all over the world and are highly valuable in cytogenetic research. In this article, we have summarized basic theories and principles employed in molecular cytogenetics, including its history in floriculture, and its application to the breeding of major flowering ornamental crops, such as lily, rose, orchid, and chrysanthemum. In addition, the key results of chromosome studies on the aforementioned flowering ornamental plants are also discussed. © 2019, Korean Society for Horticultural Science. | Hwang, Yoon-Jung; Cabahug, Raisa Aone; Mancia, Franklin Hinosa; Lim, Ki-Byung | Department of Chemistry Life Science, Sahmyook University, Seoul, 01795, South Korea, Chromosome Research Institute, Sahmyook University, Seoul, 01795, South Korea; Chromosome Research Institute, Sahmyook University, Seoul, 01795, South Korea; Department of Environmental Horticulture, Sahmyook University, Seoul, 01795, South Korea; Department of Horticultural Science, Kyungpook National University, Daegu, 41566, South Korea | 50061210800; 57211922965; 57076326300; 7403175915 | kblim@knu.ac.kr; | Horticulture Environment and Biotechnology | HORTIC ENVIRON BIOTE | 2211-3452 | 2211-3460 | 61 | 1 | SCIE | HORTICULTURE | 2020 | 1.842 | 36.5 | 0.1 | 2025-06-25 | 7 | Chromosome; Chrysanthemum; Cytogenetics; FISH; GISH; In situ hybridization | English | Final | 2020 | 10.1007/s13580-019-00198-6 | 바로가기 | 바로가기 | 바로가기 |
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