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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Evolutionary History of Mitochondrial Genomes in Discoba, Including the Extreme Halophile Pleurostomum flabellatum (Heterolobosea) | Data from Discoba (Heterolobosea, Euglenozoa, Tsukubamonadida, and Jakobida) are essential to understand the evolution of mitochondrial genomes (mitogenomes), because this clade includes the most primitive-looking mitogenomes known, as well some extremely divergent genome information systems. Heterolobosea encompassesmore than 150 described species, many of themfrom extreme habitats, but only six heteroloboseanmitogenomeshave beenfully sequencedtodate. Herewe complete themitogenome of the heterolobosean Pleurostomum flabellatum, which is extremely halophilic and reportedly also lacks classicalmitochondrial cristae, hinting at reduction or loss of respiratory function. The mitogenome of P. flabellatum maps as a 57,829-bp-long circular molecule, including 40 coding sequences (19 tRNA, two rRNA, and 19 orfs). The gene content and gene arrangement are similar to Naegleria gruberi and Naegleria fowleri, the closest relativeswith sequencedmitogenomes. The P. flabellatummitogenome contains genes that encode components of the electron transport chain similar to those of Naegleria mitogenomes. Homology searches against a draft nuclear genome showed that P. flabellatum has two homologs of the highly conserved Mic60 subunit of the MICOS complex, and likely lostMic19 andMic10. However, electronmicroscopy showednocristae structures. We infer that P. flabellatum, which originates from high salinity (313 parts per thousand) water where the dissolved oxygen concentration is low, possesses a mitochondrion capable of aerobic respiration, but with reduced development of cristae structure reflecting limited use of this aerobic capacity (e.g., microaerophily). | Ettahi, Khaoula; Lhee, Duckhyun; Sung, Ji Yeon; Simpson, Alastair G. B.; Park, Jong Soo; Yoon, Hwan Su | Sungkyunkwan Univ, Dept Biol Sci, Suwon, South Korea; Kyungpook Natl Univ, Sch Earth Syst Sci, Kyungpook Inst Oceanog, Dept Oceanog, Daegu, South Korea; Dalhousie Univ, Dept Biol, Halifax, NS, Canada; Dalhousie Univ, Ctr Comparat Genom & Evolutionary Bioinformat, Halifax, NS, Canada; Kyungpook Natl Univ, Res Inst Dok Do & Ulleung Do Isl, Daegu, South Korea | Park, Jong/AAJ-3576-2020; Yoon, Hwan Su/A-2974-2013 | 57221838250; 57193491958; 57222309614; 7402780491; 23486274100; 35239094800 | jongsoopark@knu.ac.kr;hsyoon2011@skku.edu; | GENOME BIOLOGY AND EVOLUTION | GENOME BIOL EVOL | 1759-6653 | 13 | 2 | SCIE | EVOLUTIONARY BIOLOGY;GENETICS & HEREDITY | 2021 | 4.065 | 32.4 | 0.57 | 2025-07-30 | 4 | 6 | Pleurostomum flabellatum; Heterolobosea; Naegleria with cristae; MICOS complex; microaerophily | GENE CONTENT; N. SP.; BASE-COMPOSITION; DNA; REPLICATION; DIVERSITY; EXCAVATA; ORIGIN; SELECTION; PROTISTS | Heterolobosea; MICOS complex; microaerophily; Naegleria with cristae; Pleurostomum flabellatum | Electron Transport; Eukaryota; Evolution, Molecular; Genes; Genome, Mitochondrial; Mitochondria; Mitochondrial Proteins; Phylogeny; mitochondrial protein; classification; electron transport; eukaryote; gene; genetics; mitochondrial genome; mitochondrion; molecular evolution; phylogeny; ultrastructure | English | 2021 | 2021-02 | 10.1093/gbe/evaa241 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | How do the influencing factors of health-related quality of life of the injured patient differ according to activity limitations? | Purpose This study aimed to ascertain the general characteristics of injured patients and use the Andersen Model to identify factors affecting health-related quality of life (QOL) in injured patients with or without activity limitations. Methods We used data of 1602 injured patients from 2014 to 2017 from the population-based Korea National Health and Nutrition Examination Survey, South Korea. QOL was measured using the EQ-5D-3L, and activity limitations were analyzed alongside predisposing factors (gender, age, education level, and marital status), enabling factors (basic living security, health insurance type, private insurance status, household income, and living with family), need factors (number of chronic diseases, subjective health status, and unmet medical needs), and health behaviors (smoking status, alcohol consumption, physical activity, and health screening). Data were analyzed using homogeneity testing, t tests, and logistic and multiple regression. Results The mean EQ-5D index was 0.8 with activity limitations and 0.9 without activity limitations. In mobility domain, patients without activity limitations showed significant effects of age, education level, number of chronic diseases, subjective health status, and unmet medical needs on mobility, whereas patients with activity limitations only showed a significant effect of age. In self-care domain, age, household income, and number of chronic diseases showed significant factors on patients without activity limitations, but there was no significant factor associated with activity limitations. Among the factors affecting usual activities, gender was found to have a significant effect only on patients with activity limitations, and subjective health status was found to have a significant effect regardless of activity limitations. Among the factors affecting pain/discomfort, living with family only affected pain/discomfort in patients with activity limitations. Among the factors affecting anxiety/depression, gender and alcohol consumption had significant effects only on patients with activity limitations. Conclusion Factors affecting the QOL of injured patients differed depending on whether patients had activity limitations. Therefore, when assessing injured patients, it may be necessary to ascertain the extent of activity limitations, and medical institutions and local communities need when implementing education and interventions to improve their QOL. | Lee, Eunmi; Kim, Yujeong | Hoseo Univ, Dept Nursing, 20,Hoseo Ro,79Beon Gil, Asan 31499, Chungcheongnam, South Korea; Kyungpook Natl Univ, Res Inst Nursing Sci, Coll Nursing, 680 Gukchabosangro, Daegu 41944, South Korea | ; Lee, Eunmi/AAS-2561-2020 | 57202264064; 57200941945 | cybericu@naver.com; | QUALITY OF LIFE RESEARCH | QUAL LIFE RES | 0962-9343 | 1573-2649 | 30 | 4 | SCIE;SSCI | HEALTH CARE SCIENCES & SERVICES;HEALTH POLICY & SERVICES;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2021 | 3.44 | 32.4 | 0.2 | 2025-07-30 | 3 | 3 | Injury; Trauma; Activity limitations; Andersen model; Quality of life | SPINAL-CORD-INJURY; DEPRESSION; CARE; VALIDATION; CAREGIVERS; PEOPLE; ADULTS; EQ-5D | Activity limitations; Andersen model; Injury; Quality of life; Trauma | Aged; Cross-Sectional Studies; Female; Health Status; Humans; Male; Quality of Life; Republic of Korea; Retrospective Studies; Wounds and Injuries; ADL disability; adult; age; aged; alcohol consumption; anxiety; Article; chronic disease; controlled study; cross-sectional study; depression; educational status; European Quality of Life 5 Dimensions 3 Level questionnaire; European Quality of Life 5 Dimensions questionnaire; family; female; gender; health behavior; health status; health survey; household income; human; injury; major clinical study; male; mass screening; medicaid; pain; patient mobility; physical activity; priority journal; private health insurance; public health insurance; quality of life; retrospective study; self care; smoking; South Korea; unmet medical need; health status; injury; psychology; quality of life | English | 2021 | 2021-04 | 10.1007/s11136-020-02708-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The Spt7 subunit of the SAGA complex is required for the regulation of lifespan in both dividing and nondividing yeast cells | Spt7 belongs to the suppressor of Ty (SPT) module of the Spt-Ada-Gcn5-acetyltransferase (SAGA) complex and is known as the yeast ortholog of human STAF65 gamma. Spt7 lacks intrinsic enzymatic activity but is responsible for the integrity and proper assembly of the SAGA complex. Here, we determined the role of the SAGA Spt7 subunit in cellular aging. We found that Spt7 was indispensable for a normal lifespan in both dividing and nondividing yeast cells. In the quiescent state of cells, Spt7 was required for the control of overall mRNA levels. In mitotically active cells, deletion of the SPT module had little effect on the recombination rate within heterochromatic ribosomal DNA (rDNA) loci, but loss of Spt7 profoundly elevated the plasmid-based DNA recombination frequency. Consistently, loss of Spt7 increased spontaneous Rad52 foci by approximately two-fold upon entry into S phase. These results provide evidence that Spt7 contributes to the regulation of the normal replicative lifespan (RLS) and chronological lifespan (CLS), possibly by controlling the DNA recombination rate and overall mRNA expression. We propose that the regulation of SAGA complex integrity by Spt7 might be involved in the conserved regulatory pathway for lifespan regulation in eukaryotes. | Lim, Suji; Ahn, Hyojeong; Duan, Ruxin; Liu, Yan; Ryu, Hong-Yeoul; Ahn, Seong Hoon | Hanyang Univ, Coll Sci & Convergence Technol, Dept Mol & Life Sci, ERICA Campus, Ansan 15588, South Korea; Kyungpook Natl Univ, Coll Natl Sci, BK21 Plus KNU Creat BioRes Grp, Sch Life Sci, Daegu 41566, South Korea | 57222811485; 57222812588; 55901870500; 57263978200; 55889917800; 7401989611 | rhr4757@knu.ac.kr;hoon320@hanyang.ac.kr; | MECHANISMS OF AGEING AND DEVELOPMENT | MECH AGEING DEV | 0047-6374 | 1872-6216 | 196 | SCIE | CELL BIOLOGY;GERIATRICS & GERONTOLOGY | 2021 | 5.498 | 32.4 | 0.58 | 2025-07-30 | 8 | 8 | Spt7; SAGA; Lifespan; DNA recombination; Aging | SACCHAROMYCES-CEREVISIAE; GENE-EXPRESSION; RIBOSOMAL DNA; IN-VIVO; STATIONARY-PHASE; STAGA COMPLEX; HISTONE; TRANSCRIPTION; ACETYLATION; COACTIVATOR | Aging; DNA recombination; Lifespan; SAGA; Spt7 | Cell Cycle; Cellular Senescence; Gene Expression Regulation; Longevity; Rad52 DNA Repair and Recombination Protein; Recombination, Genetic; Recombinational DNA Repair; RNA, Messenger; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Trans-Activators; Transcription Factors; messenger RNA; plasmid DNA; protein Spt7; Rad52 protein; ribosome DNA; transcription factor SAGA; unclassified drug; messenger RNA; Rad52 protein; RAD52 protein, S cerevisiae; Saccharomyces cerevisiae protein; SAGA complex, S cerevisiae; SPT7 protein, S cerevisiae; transactivator protein; transcription factor; Article; cell aging; cell cycle S phase; cell survival; DNA recombination; gene locus; heterochromatin; mitosis; mRNA expression level; nonhuman; protein depletion; protein function; protein subunit; regulatory mechanism; yeast cell; cell cycle; gene expression regulation; genetic recombination; genetics; growth, development and aging; longevity; metabolism; physiology; recombination repair; Saccharomyces cerevisiae | English | 2021 | 2021-06 | 10.1016/j.mad.2021.111480 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Comprehensive molecular profiling to predict clinical outcomes in pancreatic cancer | Background: Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis among common cancers. The genomic landscape of PDAC is defined by four mutational pathways: kirsten rat sarcoma virus (KRAS), cellular tumor antigen p53 (TP53), cyclin dependent kinase inhibitor 2A (CDKN2A), and SMAD family member 4 (SMAD4). However, there is a paucity of data on the molecular features associated with clinical outcomes after surgery or chemotherapy. Methods: We performed comprehensive molecular characterization of tumor specimens from 83 patients with PDAC who received surgery, using whole-exome sequencing and ribonucleic acid sequencing on tumor and matched normal tissues derived from patients. We also systematically performed integrative analysis, combining genomic, transcriptomic, and clinical features to identify biomarkers and possible therapeutic targets. Results: KRAS (75%), TP53 (67%), CDKN2A (12%), SMAD4 (20%), and ring finger protein 43 (RNF43) (13%) were identified as significantly mutated genes. The tumor-specific transcriptome was classified into two clusters (tumor S1 and tumor S2), which resembled the Moffitt tumor classification. Tumor S1 displayed two distinct subclusters (S1-1 and S1-2). The transcriptome of tumor S1-1 overlapped with the exocrine-like (Collisson)/ADEX (Bailey) subtype, while tumor S1-2 mostly consisted of the classical (Collisson)/progenitor (Bailey) subtype. In the analysis of combinatorial gene alterations, concomitant mutations of KRAS with low-density lipoprotein receptor related protein 1B (LRP1B) were associated with significantly worse disease-free survival after surgery (p = 0.034). One patient (1.2%) was an ultrahypermutant with microsatellite instability. We also identified high protein kinase C lota (PRKCI) expression as an overlapping, poor prognostic marker between our dataset and the TCGA dataset. Conclusion: We identified potential prognostic biomarkers and therapeutic targets of patients with PDAC. Understanding these molecular aberrations that determine patient outcomes after surgery and chemotherapy has the potential to improve the treatment outcomes of PDAC patients. | Hong, Jung Yong; Cho, Hee Jin; Kim, Seung Tae; Park, Young Suk; Shin, Sang Hyun; Han, In Woong; Lee, Jeeyun; Heo, Jin Seok; Park, Joon Oh | Sungkyunkwan Univ, Sch Med, Dept Med, Samsung Med Ctr,Div Hematol Oncol, 81 Irwon Ro, Seoul 06351, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Surg, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Hematol Oncol,Dept Med, Seoul, South Korea; Samsung Med Ctr, Precis Med Res Inst, Innovat Therapeut Res Ctr, Seoul, South Korea; Kyungpook Natl Univ, Dept Biomed Convergence Sci & Technol, Daegu, South Korea | park, youngsuk/AAV-3491-2020; Park, Junsu/IQU-2241-2023 | jsheo@skku.edu;oncopark@skku.edu; | THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY | THER ADV MED ONCOL | 1758-8340 | 1758-8359 | 13 | SCIE | ONCOLOGY | 2021 | 5.485 | 32.5 | 11 | KRAS; landscape; LRP1B; pancreatic cancer; PRKCI | MULTIDRUG-RESISTANCE; GENE; SUBTYPES; GEMCITABINE; FOLFIRINOX; LANDSCAPE | English | 2021 | 2021-08 | 10.1177/17588359211038478 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Ramucirumab plus paclitaxel as second-line treatment in patients with advanced gastric or gastroesophageal junction adenocarcinoma: a nationwide real-world outcomes in Korea study (KCSG-ST19-16) | Background: Ramucirumab as monotherapy or in combination with paclitaxel is a second-line treatment option recommended for patients with locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma. However, real-world data from large study cohorts focused on ramucirumab plus paclitaxel in gastric cancer are limited. Methods: The study population comprised all patients with gastric or GEJ cancer who received ramucirumab plus paclitaxel in South Korea between 1 May 2018 and 31 December 2018. We included patients with advanced gastric or GEJ adenocarcinoma and disease progression after first-line platinum and fluoropyrimidine-containing combination chemotherapy. Results: In total, 1063 patients were included in the present study. The objective response rate and disease control rate were 15.1% and 57.7%, respectively. The median progression-free survival was 4.03months (95% confidence interval, 3.80-4.27) and the median overall survival was 10.03months (95% confidence interval, 9.33-10.73). Grade 3 or higher treatment-related adverse events with incidence of 5% were neutropenia (35.1%) and anemia (10.5%). Based on multivariable analysis, overall survival was negatively associated with Eastern Cooperative Oncology Group performance status 2, weight loss 10% in the previous 3months, GEJ of primary tumor, poor or unknown histologic grade, number of metastatic sites 3, presence of peritoneal metastasis, no prior gastrectomy, and time to second-line since first-line treatment <6months. Conclusion: Our large-scale, nationwide, real-world data analysis of an unselected real-world population adds evidence for the efficacy and safety of second-line ramucirumab plus paclitaxel in patients with locally advanced unresectable or metastatic gastric or GEJ adenocarcinoma. | Han, Hye Sook; Kim, Bum Jun; Jee, Hee-Jung; Ryu, Min-Hee; Park, Se Hoon; Rha, Sun Young; Kim, Jong Gwang; Bae, Woo Kyun; Lee, Keun-Wook; Oh, Do-Youn; Kim, In-Ho; Sym, Sun Jin; Oh, So Yeon; Kim, Hyeong Su; Byun, Ji-Hye; Kim, Dong Sook; Suh, Young Ju; An, Hyonggin; Zang, Dae Young | Hallym Univ, Dept Internal Med, Hallym Univ Sacred Heart Hosp, Coll Med, 22 Gwanpyeong Ro 170 Beongil Dongan Gu, Anyang Si 14068, Gyeonggi Do, South Korea; Chungbuk Natl Univ, Chungbuk Natl Univ Hosp, Dept Internal Med, Coll Med, Cheongju, Chungcheongbuk, South Korea; Hallym Univ, Sacred Heart Hosp, Dept Internal Med, Coll Med, Anyang Si, Gyeonggi Do, South Korea; Korea Univ, Coll Med, Dept Biostat, Seoul, South Korea; Univ Ulsan, Asan Med Ctr, Dept Oncol, Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Dept Med, Div Hematol Oncol, Samsung Med Ctr, Seoul, South Korea; Yonsei Univ, Songdang Inst Canc Res, Coll Med, Seoul, South Korea; Yonsei Univ, Div Med Oncol, Dept Internal Med, Yonsei Canc Ctr,Coll Med, Seoul, South Korea; Yonsei Univ, Brain Korea Plus Project Med Sci 21, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Oncol Hematol, Daegu, South Korea; Chonnam Natl Univ, Dept Internal Med, Med Sch, Hwasun, Jeollanam Do, South Korea; Hwasun Hosp, Hwasun, Jeollanam Do, South Korea; Seoul Natl Univ, Coll Med, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Canc Res Inst, Dept Internal Med,Coll Med, Seoul, South Korea; Catholic Univ Korea, Dept Internal Med, Seoul St Marys Hosp, Seoul, South Korea; Gachon Univ Gil Hosp, Dept Internal Med, Div Hematol & Oncol, Incheon, South Korea; Pusan Natl Univ, Dept Internal Med, Yangsan Hosp, Yangsan, South Korea; Hallym Univ, Kangnam Sacred Heart Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Hlth Insurance Review & Assessment Serv, Innovat Res Dept, Wonju, South Korea; Hlth Insurance Review & Assessment Serv, Review & Assessment Res Dept, Wonju, South Korea; Inha Univ, Coll Med, Dept Biomed Sci, Incheon, South Korea | Oh, So Yeon/GNM-9624-2022; Kim, Hyeongsu/GWR-2904-2022; Kim, Jin Il/JWP-3629-2024; Kim, Sung-Bae/JXL-8219-2024; Park, Se Hoon/GMX-1199-2022; Jee, Hee-Jung/AAY-9026-2020; Suh, Young/AAD-5737-2021; Lee, Juhyung/JQV-8143-2023 | 7401969147; 57191250433; 57191924509; 7101754860; 25960261300; 7006023235; 59501049300; 14028001300; 35205887300; 8836932000; 55477690000; 16239809600; 57203433302; 57202791353; 57262267000; 56109775000; 35752438900; 7202277445; 57216641597 | fhdzang@hallym.or.kr; | THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY | THER ADV MED ONCOL | 1758-8340 | 1758-8359 | 13 | SCIE | ONCOLOGY | 2021 | 5.485 | 32.5 | 0.48 | 2025-07-30 | 7 | 7 | gastric cancer; paclitaxel; ramucirumab; real-world data | RANDOMIZED CLINICAL-TRIAL; PHASE-III; 1ST-LINE THERAPY; DOUBLE-BLIND; OPEN-LABEL; CANCER; CHEMOTHERAPY; RAINBOW; COMBINATION; EAST | gastric cancer; paclitaxel; ramucirumab; real-world data | fluoropyrimidine; iproplatin; nivolumab; paclitaxel; pembrolizumab; ramucirumab; abdominal pain; adult; aged; alopecia; anemia; anorexia; Article; body weight loss; cancer staging; constipation; diarrhea; disease control; disease exacerbation; drug dose reduction; drug efficacy; drug safety; drug substitution; drug withdrawal; ECOG Performance Status; epistaxis; fatigue; febrile neutropenia; female; fever; follow up; gastroesophageal junction; gastrointestinal hemorrhage; human; hypertension; infection; information processing; laboratory test; liver histology; major clinical study; male; middle aged; myalgia; nausea and vomiting; neuropathy; neutropenia; overall survival; peritoneum metastasis; progression free survival; proteinuria; rash; retrospective study; stomach cancer; stomach perforation; stomatitis; thrombocytopenia; very elderly; wound complication; young adult | English | 2021 | 2021-09 | 10.1177/17588359211042812 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Migration of Excitation Energy in Furocoumarins | The migration of excitation energy of a number of psoralen compounds has been studied. For this, the methods of induced absorption spectroscopy, stationary electron spectroscopy, fluorescence and phosphorescence, as well as quantum chemistry were used. A comparative photostability of psoralen was achieved by exposure to a XeCl excilamp irradiation (emission wavelength lambda(em) = 308 nm) with parameters Delta lambda = 5-10 nm, W-peak = 18 mW/cm(2), p = 8.1 J/cm(3), f = 200 kHz, pulse duration 1 mu s. It was found that the singlet-triplet transition played a major role in the migration of excitation energy into triplet states. Among all tested compounds, substances with an OCH3-group in the structure have the strongest effect on the spectral-luminescent characteristics. | Tchaikovskaya, O. N.; Dmitrieva, N. G.; Bocharnikova, E. N.; Chaidonova, V. S.; Avramov, P. V. | Tomsk State Univ, Dept Phys, Lab Photophys & Photochem Mol, Tomsk, Russia; Russian Acad Sci, Inst Electrophys, Lab Quantum Elect, Ekaterinburg, Russia; Siberian State Med Univ, Dept Med Biol, Tomsk, Russia; Hygien & Epidemiol Ctr Republ Khakassia, Lab Phys & Chem Methods, Abakan, Russia; Kyungpook Natl Univ, Dept Chem, Daugu, South Korea | Bryantseva, Natalia/O-6652-2014; Bocharnikova, Elena/AAF-2312-2021; Chaidonova (Kraiukhina), Vlada/Q-3179-2017; Tchaikovskaya, Olga/O-6715-2014 | 6602638099; 57347150500; 57208567909; 57214091375; 7004322420 | tchon@phys.tsu.ru;paul.avramov@gmail.com; | FRONTIERS IN CHEMISTRY | FRONT CHEM | 2296-2646 | 9 | SCIE | CHEMISTRY, MULTIDISCIPLINARY | 2021 | 5.545 | 32.7 | 0.11 | 2025-07-30 | 3 | 2 | furocoumarin; luminescence; singlet-singlet transition; triplet-triplet transition; photodynamic activity | EXCITED-STATES; PSORALEN PHOTOBIOLOGY; MODIFIED COUMARINS; PHOTOCHEMOTHERAPY; ULTRAVIOLET; CELL | furocoumarin; luminescence; photodynamic activity; singlet-singlet transition; triplet-triplet transition | English | 2021 | 2021-11-04 | 10.3389/fchem.2021.754950 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | External validation of multimodal termination of resuscitation rules for out-of-hospital cardiac arrest patients in the COVID-19 era | Background: Futile resuscitation for out-of-hospital cardiac arrest (OHCA) patients in the coronavirus disease (COVID)-19 era can lead to risk of disease transmission and unnecessary transport. Various existing basic or advanced life support (BLS or ALS, respectively) rules for the termination of resuscitation (TOR) have been derived and validated in North America and Asian countries. This study aimed to evaluate the external validation of these rules in predicting the survival outcomes of OHCA patients in the COVID-19 era. Methods: This was a multicenter observational study using the WinCOVID-19 Daegu registry data collected during February 18-March 31, 2020. The subjects were patients who showed cardiac arrest of presumed cardiac etiology. The outcomes of each rule were compared to the actual patient survival outcomes. The sensitivity, specificity, false positive value (FPV), and positive predictive value (PPV) of each TOR rule were evaluated. Results: In total, 170 of the 184 OHCA patients were eligible and evaluated. TOR was recommended for 122 patients based on the international basic life support termination of resuscitation (BLS-TOR) rule, which showed 85% specificity, 74% sensitivity, 0.8% FPV, and 99% PPV for predicting unfavorable survival outcomes. When the traditional BLS-TOR rules and KoCARC TOR rule II were applied to our registry, one patient met the TOR criteria but survived at hospital discharge. With regard to the FPV (upper limit of 95% confidence interval 99%) criteria, only the KoCARC TOR rule I, which included a combination of three factors including not being witnessed by emergency medical technicians, presenting with an asystole at the scene, and not experiencing prehospital shock delivery or return of spontaneous circulation, was found to be superior to all other TOR rules. Conclusion: Among the previous nine BLS and ALS TOR rules, KoCARC TOR rule I was most suitable for predicting poor survival outcomes and showed improved diagnostic performance. Further research on variations in resources and treatment protocols among facilities, regions, and cultures will be useful in determining the feasibility of TOR rules for COVID-19 patients worldwide. | Jung, Haewon; Lee, Mi Jin; Cho, Jae Wan; Lee, Sang Hun; Lee, Suk Hee; Mun, You Ho; Chung, Han-sol; Kim, Yang Hun; Kim, Gyun Moo; Park, Sin-youl; Jeon, Jae Cheon; Kim, Changho | Kyungpook Natl Univ, Sch Med, Dept Emergency Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Keimyung Univ, Dongsan Hosp, Dept Emergency Med, Daegu, South Korea; Catholic Univ Daegu, Sch Med, Dept Emergency Med, Daegu, South Korea; Yeungnam Univ, Coll Med, Dept Emergency Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Emergency Med, Daegu, South Korea; Daegu Fatima Hosp, Dept Emergency Med, Daegu, South Korea | ; Chung, Jaehoon/JNS-7698-2023 | 57221554827; 55507282600; 7403536065; 57210919228; 57205602138; 57210884077; 57216815984; 57216816375; 57216815900; 56184913500; 57215830861; 56441824200 | kch9754130@gmail.com; | SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE | SCAND J TRAUMA RESUS | 1757-7241 | 29 | 1 | SCIE | EMERGENCY MEDICINE | 2021 | 3.803 | 32.8 | 0.48 | 2025-07-30 | 3 | 4 | Heart arrest; Prognosis; Coronavirus disease; Ethics; Cardiopulmonary resuscitation | HEART-ASSOCIATION GUIDELINES; CARDIOPULMONARY-RESUSCITATION; LIFE-SUPPORT | Cardiopulmonary resuscitation; Coronavirus disease; Ethics; Heart arrest; Prognosis | Aged; Aged, 80 and over; Cardiopulmonary Resuscitation; COVID-19; Decision Support Techniques; Emergency Medical Services; Female; Humans; Male; Medical Futility; Middle Aged; Out-of-Hospital Cardiac Arrest; Predictive Value of Tests; Registries; Republic of Korea; Resuscitation Orders; aged; clinical trial; decision support system; emergency health service; female; human; male; middle aged; multicenter study; out of hospital cardiac arrest; predictive value; prevention and control; register; resuscitation; South Korea; treatment outcome; very elderly | English | 2021 | 2021-01-27 | 10.1186/s13049-021-00834-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | The impact of age and receipt antihypertensives to systolic blood pressure and shock index at injury scene and in the emergency department to predict massive transfusion in trauma patients | Background: Systolic blood pressure (SBP) and shock index (SI) are accurate indicators of hemodynamic instability and the need for transfusion in trauma patients. We aimed to determine whether the utility and cutoff point for SBP and SI are affected by age and antihypertensives. Methods: This was a retrospective observational study of a level 1 trauma center between January 2017 and December 2018. We analyzed the utility and cutoff points of SBP and SI for predicting massive transfusion (MT) and 30-day mortality according to patients' age and whether they were taking antihypertensives. A multivariable logistic regression analysis was conducted to estimate the association of age and antihypertensives on primary and secondary outcomes. Results: We analyzed 4681 trauma cases. There were 1949 patients aged 65 years or older (41.6%), and 1375 hypertensive patients (29.4%). MT was given to 137 patients (2.9%). The 30-day mortality rate was 6.3% (n = 294). In geriatric trauma patients taking antihypertensives, a prehospital SBP less than 110 mmHg was the cutoff value for predicting MT in multivariate logistic regression analyses; packed red blood cell transfusion volume decreased abruptly based on prehospital SBP of 110 mmHg. Emergency Department SI greater than 1.0 was the cutoff value for predicting MT in patients who were older than 65 years and were not taking antihypertensives. Conclusions: The triage of trauma patients is based on the identification of clinical features readily identifiable by first responders. However, age and medications may also affect the accurate evaluation. In initial trauma management, we must apply SBP and SI differently depending on age, whether a patient is taking antihypertensives, and the time at which the indicators are measured. | Park, Se Jin; Lee, Mi Jin; Kim, Changho; Jung, Haewon; Kim, Seong Hun; Nho, Wooyoung; Seo, Kang Suk; Park, Jungbae; Ryoo, Hyun Wook; Ahn, Jae Yun; Moon, Sungbae; Cho, Jae Wan; Son, Shin-ah | Kyungpook Natl Univ, Sch Med, Dept Emergency Med, Daegu, South Korea; CHA Univ, Gumi CHA Med Ctr, Dept Emergency Med, Gumi, South Korea; Kyungpook Natl Univ, Sch Med, Dept Thorac & Cardiovasc Surg, Daegu, South Korea | Nho, Woo Young/JLN-0752-2023; Park, Jae Yong/ISS-5916-2023; Ahn, Jae Yun/N-2652-2017 | 57221239353; 55507282600; 56441824200; 57221554827; 57215836673; 57215831839; 57204305189; 57189030435; 55350557500; 56937505400; 57191584601; 7403536065; 57197328338 | emmam@knu.ac.kr; | SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE | SCAND J TRAUMA RESUS | 1757-7241 | 29 | 1 | SCIE | EMERGENCY MEDICINE | 2021 | 3.803 | 32.8 | 0.6 | 2025-07-30 | 7 | 6 | Emergency medical services; Geriatrics; Antihypertensives; Massive transfusion; Shock index; Systolic blood pressure | VITAL SIGNS; MORTALITY; TRIAGE; HYPOTENSION; MANAGEMENT; NEED | Antihypertensives; Emergency medical services; Geriatrics; Massive transfusion; Shock index; Systolic blood pressure | Age Factors; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Blood Transfusion; Cross-Sectional Studies; Female; Humans; Male; Retrospective Studies; Shock; Systole; Trauma Centers; Triage; Wounds and Injuries; antihypertensive agent; age; aged; blood pressure; blood transfusion; cross-sectional study; emergency health service; female; human; injury; male; retrospective study; shock; systole; very elderly | English | 2021 | 2021-01-30 | 10.1186/s13049-021-00840-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Exogenous melatonin induces drought stress tolerance by promoting plant growth and antioxidant defence system of soybean plants | Melatonin is an indolamine bioactive molecule that regulates a wide range of physiological processes during plant growth and enhances abiotic stress tolerance. Here we examined the putative role of exogenous melatonin application (foliar or root zone) in improving drought stress tolerance in soybean seedlings. Pre-treatment of soybean seedlings with melatonin (50 and 100 mu M) was found to significantly mitigate the negative effects of drought stress on plant growth-related parameters and chlorophyll content. The beneficial impacts against drought were more pronounced by melatonin application in the rhizosphere than in foliar treatments. The melatonin-induced enhanced tolerance could be attributed to improved photosynthetic activity, reduction of abscisic acid and drought-induced oxidative damage by lowering the accumulation of reactive oxygen species and malondialdehyde. Interestingly, the contents of jasmonic acid and salicylic acid were significantly higher following melatonin treatment in the root zone than in foliar treatment compared with the control. The activity of major antioxidant enzymes such as superoxide dismutase, catalase, polyphenol oxidase, peroxidase and ascorbate peroxidase was stimulated by melatonin application. In addition, melatonin counteracted the drought-induced increase in proline and sugar content. These findings revealed that modifying the endogenous plant hormone content and antioxidant enzymes by melatonin application improved drought tolerance in soybean seedlings. Our findings provide evidence for the stronger physiological role of melatonin in the root zone than in leaves, which may be useful in the large-scale field level application during drought. | Imran, Muhammad; Khan, Abdul Latif; Shahzad, Raheem; Khan, Muhammad Aaqil; Bilal, Saqib; Khan, Adil; Kang, Sang-Mo; Lee, In-Jung | Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea; Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa 616, Oman; Univ Haripur, Dept Hort, Haripur 21120, Pakistan; Texas Tech Univ, Dept Plant & Soil Sci, Lubbock, TX 79409 USA | Khan, Abdul/B-1005-2010; Imran, Muhammad/AFL-6590-2022; Lee, In-Jung/GLS-0432-2022; Kang, Sang-Mo/MBG-7823-2025; Khan, Adil/AAC-5160-2022; Khan, Muhammad/ABB-9797-2021; Shahzad, Raheem/AAG-8370-2019 | 58282433800; 26639372800; 56454250900; 57188585606; 57031617400; 59815813500; 56189696900; 16425830900 | ijlee@knu.ac.kr; | AOB PLANTS | AOB PLANTS | 2041-2851 | 13 | 4 | SCIE | ECOLOGY;PLANT SCIENCES | 2021 | 3.138 | 32.9 | 11.03 | 2025-07-30 | 145 | 157 | Antioxidants; drought stress; melatonin; phytohormones; soybean | SPHINGOMONAS SP LK11; SUPEROXIDE-DISMUTASE; OXIDATIVE STRESS; SALT STRESS; ACID; ABA; CHLOROPLASTS; RESISTANCE; WHEAT; BIOSYNTHESIS | Antioxidants; drought stress; melatonin; phytohormones; soybean | English | 2021 | 2021-07-04 | 10.1093/aobpla/plab026 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Synthesis of Trinuclear Benzimidazole-Fused Hybrid Scaffolds by Transition Metal-Free Tandem C(sp²)-N Bond Formation under Microwave Irradiation | 2-(2-Bromoaryl)- and 2-(2-bromovinyl)benzimidazoles have been coupled and cyclized with 2-methoxy- and 2-aryloxybenzimidazoles as building blocks in the presence of a base under microwave irradiation to give a class of trinuclear N-fused hybrid scaffolds, benzo[4,5]imidazo[1,2-a]benzo[4,5]imidazo[1,2-c]quinazolines and -pyrimidines, respectively, in good yields. 2-(2-Bromoaryl)- and 2-(2-bromovinyl)imidazoles also reacted with 2-methoxybenzimidazoles in the presence of base under microwave irradiation to give a class of trinuclear N-fused hybrid scaffolds, benzo[4,5]imidazo[1,2-a]imidazo[1,2-c]quinazolines and -pyrimidines, respectively, in similar yields. This process seems to proceed via an initial C(sp(2))-N coupling by an addition-elimination nucleophilic aromatic substitution (SNAr) and subsequent cyclization accompanied by extrusion of alcohols. | Dao, Pham Duy Quang; Cho, Chan Sik | Kyungpook Natl Univ, Dept Appl Chem, 80 Daehakro, Daegu 41566, South Korea | Dao, P. D. Quang/AAR-9880-2021 | 57194217171; 7403100019 | cscho@knu.ac.kr; | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | EUR J ORG CHEM | 1434-193X | 1099-0690 | 2021 | 29 | SCIE | CHEMISTRY, ORGANIC | 2021 | 3.261 | 33.0 | 0.75 | 2025-07-30 | 9 | 9 | Aromatic substitution; Cross-coupling; Microwave chemistry; Nucleophilic substitution; Nitrogen heterocycles | C-N; ONE-POT; H FUNCTIONALIZATION; ARYNES | Aromatic substitution; Cross-coupling; Microwave chemistry; Nitrogen heterocycles; Nucleophilic substitution | English | 2021 | 2021-08-06 | 10.1002/ejoc.202100419 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Cervical Alignment Following Posterior Cervical Fusion Surgery Cervical Pedicle Screw Versus Lateral Mass Screw Fixation | Study Design. Retrospective comparative study. Objective. The aim of this study was to compare cervical sagittal alignment after posterior fusion surgery with lateral mass screw (LMS) and cervical pedicle screw (CPS) fixation. Summary of Background Data. LMS fixation in the subaxial cervical spine has become the preferred method of posterior cervical fusion. Although CPS has biomechanical benefits, it also has neurovascular risks. Few studies to date have compared sagittal alignment changes after posterior cervical fusion using CPS and LMS fixation. Methods. From 2006 to 2017, 71 consecutive patients underwent posterior cervical fusion using CPS (n = 51) or LMS (n = 20) fixation. Patients who underwent fusion with both types of screws and those who planned to undergo additional anterior fusion surgery were excluded. The minimum follow-up period was 12 months. C2-C7 Cobb angle for cervical lordosis (CL), fusion segmental angle (SA), C2-C7 sagittal vertical axis (SVA), and T1 slope (T1S) were measured. Results. Immediate postoperative SA and SVA differed significantly in patients who underwent CPS and LMS fixation. SA changes were more substantial after CPS fixation, with a significant difference maintained until final follow-up. Over time, CL, SVA, and T1S tended to return to their preoperative states regardless of screw type. Two patients who underwent LMS fixation, but none who underwent CPS fixation, required unplanned or additional anterior fusion surgery for revision. Conclusion. The present study is the first radiologic comparison of LMS and CPS fixation after posterior-only fusion surgery. CPS resulted in more reliable and well-preserved SA correction, whereas CL and SVA did not differ between the two groups over time due to loss of correction. | Lee, Subum; Cho, Dae-Chul; Roh, Sung Woo; Jeon, Sang Ryong; Moon, Eun Ji; Lee, Jung Jae; Park, Jin Hoon | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Neurosurg, Sch Med, Daegu, South Korea; Univ Ulsan, Man Med Ctr, Dept Neurol Surg, Coll Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea; Univ Ulsan, Gangneung Man Hosp, Dept Neurol Surg, Coll Med, Kangnung, South Korea | Lee, Subum/AFQ-2764-2022; Lee, Yoon/ABA-8808-2020 | 57193631061; 55859543400; 7004951729; 57203521670; 57216160775; 57196137928; 36898773700 | jhpark@amc.seoul.kr; | SPINE | SPINE | 0362-2436 | 1528-1159 | 46 | 10 | SCIE | CLINICAL NEUROLOGY;ORTHOPEDICS | 2021 | 3.269 | 33.1 | 1.92 | 2025-07-30 | 17 | 17 | cervical pedicle screw; cervical sagittal alignment; complication; lateral mass screw; posterior cervical fusion; T1 slope | T1 SLOPE; SPINE; REDUCTION; PLACEMENT | Cervical pedicle screw; Cervical sagittal alignment; Complication; Lateral mass screw; Posterior cervical fusion; T1 slope | adult; Article; biomechanics; cervical sagittal alignment; cervical spine; Cobb angle; cohort analysis; comparative study; controlled study; female; follow up; human; lordosis; major clinical study; male; middle aged; outcome assessment; posterior spine fusion; retrospective study; sagittal vertical axis; spine stabilization | English | 2021 | 2021-05-15 | 10.1097/brs.0000000000003845 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Editorial Material | Comment on: ``The modified extended tanh-function method for solving Burgers-type equations'' [Physica A 361 (2006) 394-404] | In this letter, we analyze the paper by Soliman (2006). Using the modified extended tanh-function (METF) method, Soliman have found exact "solutions'' of the Burgers type equations including one-dimensional Burgers and coupled Burgers equations. In this comment, we show that none of these solutions satisfy the corresponding Burgers equations. In addition, we provide the corrected exact solutions by correcting some Soliman's mistakes and errors. (C) 2021 Elsevier B.V. All rights reserved. | Piao, Xiangfan; Kim, Philsu | Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea | 54906916500; 7402334786 | piaoxf76@hanmail.net;kimps@knu.ac.kr; | PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS | PHYSICA A | 0378-4371 | 1873-2119 | 569 | SCIE | PHYSICS, MULTIDISCIPLINARY | 2021 | 3.778 | 33.1 | 0.71 | 2025-07-30 | 5 | 6 | Burgers' equation; Coupled Burgers' equation; METF method | SIMPLEST EQUATION; NUMERICAL-SIMULATION; SCHEMES; MODEL | Burgers’ equation; Coupled Burgers’ equation; METF method | Burgers equations; Exact solution; Tanh functions; Tanh-function method; Physics | English | 2021 | 2021-05-01 | 10.1016/j.physa.2021.125771 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Energy-conserving DPD and thermodynamically consistent Fokker-Planck equation | The original Fokker-Planck equation does not satisfy most balance equations of continuum mechanics. Dissipative particle dynamics (DPD) is an attempt to remedy the demerits of the Fokker-Planck equation. However, a desirable kinetic equation should satisfy the four balance equations of irreversible thermodynamics, i.e., the balance equations of mass, momentum, energy, and entropy. To the best of the author's knowledge, only the Boltzmann kinetics fulfills all the conditions. We suggest a modified Fokker-Planck equation that satisfies all the conditions without the assumption of DPD, the pairwise additivity of dissipative and random forces. Our formalism is expected to minimize the number of adjustable functions that must be used in DPD. (c) 2021 Published by Elsevier B.V. | Cho, Kwang Soo | Kyungpook Natl Univ, Dept Polymer Sci & Engn, Daegu, South Korea | 56316379300 | polphy@knu.ac.kr; | PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS | PHYSICA A | 0378-4371 | 1873-2119 | 583 | SCIE | PHYSICS, MULTIDISCIPLINARY | 2021 | 3.778 | 33.1 | 0.24 | 2025-07-30 | 2 | 3 | Dissipative particle dynamics; Fokker-Planck equation; Irving-Kirkwood procedure; Energy conservation; Pairwise additivity | DISSIPATIVE PARTICLE DYNAMICS | Dissipative particle dynamics; Energy conservation; Fokker–Planck equation; Irving–Kirkwood procedure; Pairwise additivity | Boltzmann equation; Continuum mechanics; Fokker Planck equation; Thermodynamics; Balance equations; Condition; Dissipative particle dynamics; Energy; Energy-conserving; Fokker-Planck-equation; Irreversible thermodynamics; Irving–kirkwood procedure; Kinetic equations; Pairwise additivity; Energy conservation | English | 2021 | 2021-12-01 | 10.1016/j.physa.2021.126285 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Evaluation of liquefied natural gas bunkering port selection | Given environment regulations on emissions from ships, shipping companies have sought alternative fuel ships, such as LNG-powered vessels, which may give rise to growth in liquefied natural gas (LNG) bunkering ports. Because demand for LNG-powered vessels is expected to increase, it is worth assessing the factors that lead to the selection of LNG bunkering ports in LNG bunkering industries. However, a lack of academic research exists in the field of LNG bunkering port selection. This paper employs a second-stage empirical analysis approach that selects criteria for shipping companies' selection of a LNG bunkering port through a literature review and interviews, and then adopts a fuzzy-AHP methodology to reveal the priority of the LNG bunkering port selection criteria in LNG bunkering decision making. The results indicate that most shipping companies decide on a LNG bunkering port with a stronger emphasis on safety/security or port services rather than port reputation. This paper offers invaluable policy implications for governments and port authorities that plan to build and operate LNG bunkering ports in the near future. | Kim, A-Rom; Kwak, Dong-Wook; Seo, Young-Joon | Res Inst Gangwon, Chunchon, South Korea; Coventry Univ, Coventry Business Sch, Coventry, W Midlands, England; Kyungpook Natl Univ, Sch Econ & Trade, Daegu, South Korea | ; Seo, Young-Joon/AAY-6105-2021 | 57202101135; 56439004200; 56999695700 | y.seo@knu.ac.kr; | INTERNATIONAL JOURNAL OF LOGISTICS-RESEARCH AND APPLICATIONS | INT J LOGIST-RES APP | 1367-5567 | 1469-848X | 24 | 3 | SSCI | MANAGEMENT | 2021 | 5.992 | 33.1 | 1 | 2025-07-30 | 17 | 20 | Liquefied natural gas; LNG bunkering; seaport; port selection; fuzzy-AHP | FUZZY-AHP; REDUCTION; EMISSIONS; CARRIERS | fuzzy-AHP; Liquefied natural gas; LNG bunkering; port selection; seaport | English | 2021 | 2021-05-04 | 10.1080/13675567.2019.1642311 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | The Effects of Paraspinal Muscle Volume on Physiological Load on the Lumbar Vertebral Column | Study Design. Analytical biomechanical study using a finite-element (FE) model. Objective. We investigated the effects of paraspinal muscle volume to the physiological loading on the lower lumbar vertebral column using a FE model. Summary of Background Data. The FE model analysis can measure the physiological load on the lumbar vertebral column. Which changes as the surrounding environment changes. In this study, our FE model consisted of the sacrum, lumbar spine (L3-L5), intervertebral discs, facet joints, and paraspinal muscles. Methods. Three-dimensional FE models of healthy lumbar spinal units were reconstructed. The physiological loads exerted on the lumbar vertebra column were evaluated by applying different paraspinal muscle volumes (without muscles, 50%, 80%, and 100% of healthy muscle volume). Results. As the paraspinal muscle volume increased, the loads exerted on the vertebral column decreased. The mean load on the intervertebral disc was 1.42 +/- 0.75 MPa in the model without muscle, 1.393 +/- 0.73 MPa in the 50% muscle volume model, 1.367 +/- 0.71 MPa in the 80% muscle volume model, and 1.362 +/- 0.71 MPa in the 100% muscle volume model. The mean loads exerted on the posterior column of lumbar spine were 11.79 +/- 4.70 MPa in the model without muscles, 11.57 +/- 4.57 MPa in the model with 50% muscle volume, and 11.13 +/- 4.51 MPa in the model with 80% muscle volume, and 10.92 +/- 4.33 MPa in the model with 100% muscle volume. The mean pressure on the vertebral body in the model without paraspinal muscle, and with 50%, 80%, and 100% paraspinal muscle volume were 14.02 +/- 2.82, 13.82 +/- 2.62, 13.65 +/- 2.61, and 13.59 +/- 2.51 MPa, respectively. Conclusion. Using FEM, we observed that the paraspinal muscle volume decreases pressure exerted on the lumbar vertebral column. Based on these results, we believe that exercising to increase paraspinal muscle volume would be helpful for spinal pain management and preventing lumbar spine degeneration. | Kang, Sungwook; Chang, Min Cheol; Kim, Hwanjin; Kim, Jaewoong; Jang, Youngjae; Park, Donghwi; Hwang, Jong-Moon | Korea Inst Ind Technol, Dongnam Div, Precis Mech Proc & Control R&D Grp, Jinju, South Korea; Yeungnam Univ, Coll Med, Dept Rehabil Med, Daegu, South Korea; Korea Inst Ind Technol, Seonam Div, Smart Mobil Mat & Components R&D Grp, Gwangju, South Korea; Hyundai Heavy Ind, Ship Struct Res Dept, Ulsan, South Korea; Univ Ulsan, Ulsan Univ Hosp, Dept Phys Med & Rehabil, Coll Med, Ulsan, South Korea; Kyungpook Natl Univ Hosp, Dept Rehabil Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Rehabil Med, Daegu, South Korea | Chang, Min Cheol/AAE-2321-2022; Park, Donghwi/GYQ-6185-2022; Kim, Yun-Gon/HLP-9951-2023; KANG, SUNGWOOK/AAF-6339-2021 | 55611458600; 57991534800; 57215072363; 7601367283; 58375325600; 56606561400; 56367634000 | hti820@hanmail.net;hti82@hanmail.net; | SPINE | SPINE | 0362-2436 | 1528-1159 | 46 | 19 | SCIE | CLINICAL NEUROLOGY;ORTHOPEDICS | 2021 | 3.269 | 33.1 | 2.71 | 2025-07-30 | 28 | 29 | finite-element analysis; intervertebral disc; lumbar spine; muscle volume; paraspinal muscle; vertebral body | VIVO INTRADISCAL PRESSURE; CROSS-SECTIONAL AREA; LOW-BACK-PAIN; INTERVERTEBRAL DISCS; MULTIFIDUS; HERNIATION; MANAGEMENT; SYMPTOMS; MOTION; PSOAS | finite-element analysis; intervertebral disc; lumbar spine; muscle volume; paraspinal muscle; vertebral body | Biomechanical Phenomena; Finite Element Analysis; Humans; Intervertebral Disc; Lumbar Vertebrae; Lumbosacral Region; Paraspinal Muscles; Zygapophyseal Joint; biomechanics; diagnostic imaging; finite element analysis; human; intervertebral disk; lumbar vertebra; lumbosacral region; paraspinal muscle; zygapophyseal joint | English | 2021 | 2021-10-01 | 10.1097/brs.0000000000004014 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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