연구성과로 돌아가기
2025 연구성과 (129 / 151)
※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ○ | ○ | Article | Primary Cutaneous CD30+Lymphoproliferative Disorders in South Korea: A Nationwide, Multi-Center, Retrospective, Clinical, and Prognostic Study | Background: Primary cutaneous CD30+ lymphoproliferative disorders (pcCD30-LPDs) are a diseases with various clinical and prognostic characteristics. Objective: Increasing our knowledge of the clinical characteristics of pcCD30-LPDs and identifying potential prognostic variables in an Asian population. Methods: Clinicopathological features and survival data of pcCD30-LPD cases obtained from 22 hospitals in South Korea were examined. Results: A total of 413 cases ofpcCD30-LPDs (lymphomatoid papulosis [LYP], n=237; primary cutaneous anaplastic large cell lymphoma [C-ALCL], n=176) were included. Ninety percent of LYP patients and roughly 50% of C-ALCL patients presented with multiple skin lesions. Both LYP and C-ALCL affected the lower limbs most frequently. Multiplicity and advanced T stage of LYP lesions were associated with a chronic course longer than 6 months. Clinical morphology with patch lesions and elevated serum lactate dehydrogenase were significantly associated with LPDs during follow-up in LYP patients. Extracutaneous involvement of C-ALCL occurred in 13.2% of patients. Lesions larger than 5 cm and increased serum lactate dehydrogenase were associated with a poor prognosis in C-ALCL. The survival of patients with C-ALCL was unaffected by the anatomical locations of skin lesions or other pathological factors. Conclusion: The multiplicity or size of skin lesions was associated with a chronic course of LYP and survival among patients with C-ALCL. | Lee, Woo Jin; Yun, Sook Jung; Jung, Joon Min; Ko, Joo Yeon; Kim, Kwang Ho; Kim, Dong Hyun; Kim, Myung Hwa; Kim, You Chan; Kim, Jung Eun; Na, Chan-Ho; Mun, Je-Ho; Park, Jong Bin; Park, Ji-Hye; Park, Hai-Jin; Shin, Dong Hoon; Shin, Jeonghyun; Oh, Sang Ho; Yun, Seok-Kweon; Lee, Dongyoun; Lee, Seok-Jong; Lee, Seung Ho; Lee, Young Bok; Cho, Soyun; Choi, Sooyeon; Choi, Jae Eun; Lee, Mi Woo | Univ Ulsan, Coll Med, Asan Med Ctr, Dept Dermatol, 88 Olympic Ro 43 Gil, Seoul 05505, South Korea; Chonnam Natl Univ, Med Sch, Dept Dermatol, Gwangju, South Korea; Hanyang Univ, Coll Med, Seoul Hosp, Dept Dermatol, Seoul 04763, South Korea; Hallym Univ, Sacred Heart Hosp, Dept Dermatol, Anyang, South Korea; CHA Univ, Sch Med, CHA Bundang Med Ctr, Dept Dermatol, Seongnam, South Korea; Dankook Univ, Med Ctr, Environm Hlth Ctr, Cheonan, South Korea; Ajou Univ, Sch Med, Dept Dermatol, Suwon, South Korea; Soonchunhyang Univ, Soonchunhyang Univ Cheonan Hosp, Coll Med, Dept Dermatol, Cheonan, South Korea; Chosun Univ, Coll Med, Dept Dermatol, Gwangju, South Korea; Seoul Natl Univ, Coll Med, Dept Dermatol, Seoul, South Korea; Kosin Univ, Coll Med, Dept Dermatol, Busan, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Dermatol, Seoul, South Korea; Gwangmyeong Sungae Hosp, Dept Dermatol, Gwangmyeong, South Korea; Yeungnam Univ, Coll Med, Dept Dermatol, Daegu 705703, South Korea; Inha Univ, Sch Med, Dept Dermatol, Incheon, South Korea; Yonsei Univ, Coll Med, Severance Hosp, Seoul, South Korea; Yonsei Univ, Severance Hosp, Coll Med, Cutaneous Biol Res Inst, Seoul, South Korea; Jeonbuk Natl Univ, Med Sch, Dept Dermatol, Jeonju, South Korea; Kyungpook Natl Univ, Sch Med, Dept Dermatol, Daegu, South Korea; Dongguk Univ, Ilsan Hosp, Dept Dermatol, Goyang 410773, South Korea; Catholic Univ Korea, Coll Med, Dept Dermatol, Seoul, South Korea; Boramae Med Ctr, Seoul, South Korea; Eulji Univ, Sch Med, Nowon Eulji Med Ctr, Dept Dermatol, Seoul, South Korea | Lee, Joong/A-5417-2013 | 55619313075; 7202777335; 57039408600; 57220979822; 55710515500; 55574224600; 56192953300; 57194621494; 56508490400; 24475283700; 37052613800; 44961427000; 57211684961; 55667200300; 59740766600; 55641464400; 25823284300; 7202777428; 15056373700; 56013454400; 57203597327; 36066866100; 7404885142; 57222726503; 57109506900; 58742270800 | miumiu@amc.seoul.kr; | ANNALS OF DERMATOLOGY | ANN DERMATOL | 1013-9087 | 2005-3894 | 37 | 2 | SCIE | DERMATOLOGY | 2024 | 1.3 | 69.3 | 0 | 2025-05-07 | 0 | 0 | Anaplastic large cell lymphoma; Clinical course; Cutaneous T-cell lymphoma; Lymphomatoid papulosis; Prognostic factors | LARGE-CELL LYMPHOMA; TNM CLASSIFICATION-SYSTEM; LYMPHOPROLIFERATIVE DISORDERS; MYCOSIS-FUNGOIDES; EUROPEAN-ORGANIZATION; PAPULOSIS; SURVIVAL; ASSOCIATION; DIAGNOSIS; FEATURES | Anaplastic large cell lymphoma; Clinical course; Cutaneous T-cell lymphoma; Lymphomatoid papulosis; Prognostic factors | lactic acid; methotrexate; steroid; adult; anatomical location; Article; Asian; cancer prognosis; cancer recurrence; cancer staging; cancer survival; chronic disease; clinical feature; clinical study; cohort analysis; computer assisted tomography; controlled study; disease course; disease duration; female; follow up; histopathology; hospital; human; human tissue; immunophenotyping; immunosuppressive treatment; lactate dehydrogenase blood level; lower limb; lymphomatoid papulosis; major clinical study; male; middle aged; population research; positron emission tomography; primary cutaneous anaplastic large cell lymphoma; primary cutaneous CD30+ T cell lymphoproliferative disorder; retrospective study; skin defect; South Korea | English | 2025 | 2025-04 | 10.5021/ad.24.120 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Effect of salinity stress on carbon assimilation, biochemical composition, and bioenergy potential of the microalga Coelastrella sp. KNUA068 | Microalgae, photosynthetic organisms that fix carbon dioxide, exhibit rapid growth and are considered promising as next-generation energy sources. The production of various intracellular biochemical products and bioactive compounds in microalgae increases under diverse stress conditions. However, exposure to concentrations beyond a certain level can act toxically, hindering overall microalgae productivity. This study explored the effects of varying concentrations of MgCl2 (75, 150 mM) and NH4Cl (8, 16 mM) on the indigenous microalgal strain Coelastrella sp. KNUA068 over 14 days. The findings indicate that higher concentrations of these chemicals reduced microalgae growth and diminished chlorophyll and carotenoid levels, except for the group treated with 8 mM NH4Cl, which showed an increase in these pigments. This suggests that moderate NH4Cl concentration acts as a beneficial nitrogen source rather than just a stressor. Biomass analysis revealed enhanced calorific value, lipid content, and protein content in NH4Cl-treated groups, unlike the MgCl2 groups, where only cetane numbers were higher. Additionally, biogas production from microalgal biomass was more productive compared to the control, indicating that specific stress conditions can improve biochemical compound productivity in Coelastrella sp. KNUA068, making it a promising bioenergy feedstock. © 2025 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. | Do, Jeong-Mi; Yeo, Hee-Tae; Suh, Ho-Seong; Seo, Yu-Hee; Choi, Ha Neul; Park, Su-Bin; Yoon, Ho-Sung | Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, South Korea, BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, South Korea, Blue Carbon Research Center, Kyungpook National University, Daegu, South Korea; Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, South Korea, BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, South Korea; Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, South Korea, BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, South Korea, Blue Carbon Research Center, Kyungpook National University, Daegu, South Korea; Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, South Korea, BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, South Korea, Blue Carbon Research Center, Kyungpook National University, Daegu, South Korea; Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, South Korea; Biological Resources Research Department, Nakdonggang National Institute of Biological Resources (NNIBR), Sangju, South Korea; Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, South Korea, BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, South Korea, Blue Carbon Research Center, Kyungpook National University, Daegu, South Korea, Advanced Bio-resource Research Center, Kyungpook National University, Daegu, South Korea | 57208562245; 57224478334; 58139501200; 59489877900; 59540926900; 57201732680; 7402990205 | hsy@knu.ac.kr; | Biofuels | BIOFUELS-UK | 1759-7269 | 1759-7277 | SCIE | ENERGY & FUELS | 2024 | 2.6 | 69.5 | 0 | 2025-05-07 | 0 | bioenergy; biogas; carotenoid; Microalgae; salinity stress | Chlorine compounds; Bio-energy; Biochemical composition; Bioenergy potential; Carbon assimilation; Micro-algae; Microalga; Photosynthetic organisms; Rapid growth; Salinity stress; Stress condition; Microalgae | English | Article in press | 2025 | 10.1080/17597269.2025.2456400 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | Article | Brazing characteristics of vertical joints with silver copper eutectic alloy Ag72Cu28 for RFQ section brazing stage | A radio-frequency quadrupole (RFQ) is a critical component in particle accelerator technology, and section brazing is a crucial fabrication process in this context. This study investigates the brazing characteristics of vertical joints created using Ag72Cu28 metal filler in a high-vacuum environment. Experimental specimens were prepared with copper plates and brazed at temperatures ranging from 778 to 805° C to analyze the melting behavior of the filler. X-ray computerized tomography (CT) scans revealed that the filler begins to melt at 782° C and that complete melting occurs at 784° C. It was found that maintaining temperatures of above 780° C for at least 17 min ensures optimal bonding, while temperatures below this can result in incomplete melting and potential vacuum leaks. Conversely, excessively high temperatures can cause filler overflow and require additional machining. This study provides critical insights regarding the precise temperature control required for successful RFQ section brazing, addressing the challenges of vacuum leaks and incomplete filler melting. These findings offer practical guidelines related to the minimum brazing temperature and brazing time for improving RFQ manufacturing reliability, particularly for vertical joint configurations. © The Korean Physical Society 2025. | Kim, Kyung Hyun; Hong, Jung Goo | Korea Multi-Purpose Accelerator Complex, Korea Atomic Energy Research Institute, Gyeongju, 38180, South Korea, School of Mechanical Engineering, Kyungpook National University, Bukgu, Daegu, 41566, South Korea; School of Mechanical Engineering, Kyungpook National University, Bukgu, Daegu, 41566, South Korea | 57204432703; 24576652200 | jghong70@knu.ac.kr; | Journal of the Korean Physical Society | J KOREAN PHYS SOC | 0374-4884 | 1976-8524 | SCIE | PHYSICS, MULTIDISCIPLINARY | 2024 | 0.9 | 69.7 | 0 | 2025-05-07 | 0 | Ag72Cu28 filler; Capillary; KOMAC; RFQ; Section brazing; Vacuum brazing | Brazing filler metals; Copper; Copper alloys; Accelerator technology; Ag72cu28 filler; Capillary; Critical component; Eutectic alloys; Fabrication process; KOMAC; Radio-frequency quadrupole; Section brazing; Vacuum leak; Vacuum brazing | English | Article in press | 2025 | 10.1007/s40042-025-01333-6 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | Article | Dysprosium-doped lithium borate glass for dosimetry applications | Lithium borate glass and dysprosium (Dy3+) ions are tissue-equivalent materials for radiation dosimetry due to their effective atomic numbers, which closely resemble those of human tissue and light emission properties of Dy3+ ions. Lithium borate glasses with compositions (50-x)Li2O:50B2O3: xDy2O3 (where x= 0.1, 0.2, 0.5, 0.7, and 1 mol %), labeled as LBD1, and (100-y)B2O3:(y-0.5)Li2O:0.5 Dy2O3 (where y= 30, 40, 45, 50, 55 mol %), labeled as LBD2, were fabricated using the melt-quench method. The properties analyzed include structural, X-ray and proton-induced luminescence, optical, photoluminescence (PL), and thermoluminescence (TL). XRD spectra confirmed amorphous structure with broad humps and no sharp peaks. X-ray luminescence shows two highest peaks at 575 nm and 484 nm due to the 4F9/2 →6H13/2 and 4F9/2 → 6H15/2 transition, respectively. PL excitation spectra show seven peaks from Dy3+ due to 4f–4f transitions, with emission spectra at 484 nm (blue) and 575 nm (yellow). LBD1 glass, doped with 0.5 mol% Dy2O3, exhibits highest intensity in both X-ray luminescence and PL measurements. The proton-induced spectrum exhibits peak around 450–500 nm and 550–600 nm. The PL intensity increases under 349 nm laser excitation. Optical band-gap energies decrease with increasing concentrations of Dy3+ ions. After X-ray irradiation, the samples exhibit high-intensity TL peaks around 137–187 °C measured from 10 min to 48 h post-irradiation. These findings emphasize the distinctive features of dysprosium-doped lithium borate glasses, making them valuable for various purposes, particularly in photonics, laser, radiation detection, and dosimetry. © The Korean Physical Society 2025. | Felix, Anastazia Tarimo; Ton, Nguyen Duc; Cho, Jaeyoung; Luan, Nguyen Thanh; Daniel, D. Joseph; Anjum, Faizan; Ali, Syed Azaz; Kim, Hong Joo | Department of Physics, Kyungpook National University, Daegu, 41566, South Korea; Department of Physics, Kyungpook National University, Daegu, 41566, South Korea; Department of Physics, Kyungpook National University, Daegu, 41566, South Korea; The Center for High Energy Physics, Kyungpook National University, Daegu, 41566, South Korea; Department of Physics, Kyungpook National University, Daegu, 41566, South Korea; Department of Physics, Kyungpook National University, Daegu, 41566, South Korea; Department of Physics, Kyungpook National University, Daegu, 41566, South Korea, The Center for High Energy Physics, Kyungpook National University, Daegu, 41566, South Korea | 59888605100; 57966935300; 57204422573; 57210576969; 35319662800; 57219469502; 59731999500; 58483690400 | hongjoo@knu.ac.kr; | Journal of the Korean Physical Society | J KOREAN PHYS SOC | 0374-4884 | 1976-8524 | SCIE | PHYSICS, MULTIDISCIPLINARY | 2024 | 0.9 | 69.7 | 0 | 2025-05-07 | 0 | Dy<sup>3</sup>⁺ ions; Lithium borate glass; Photoluminescence; Proton; Radiation dosimetry; Thermoluminescence; X-ray | Borophosphate glass; Dosimetry; Irradiation; Laser beams; Laser excitation; Optical band gaps; Optical emission spectroscopy; Photoluminescence; Thermoluminescence; Dy3⁺ ion; Effective atomic number; High intensity; Human tissues; Light emission properties; Lithium borate glass; Melt-quench method; Tissue-equivalent materials; X ray luminescence; Tissue | English | Article in press | 2025 | 10.1007/s40042-025-01347-0 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | Article | On-chip electrical excitation of micromembrane for fully integrated high-frequency, multi-mode optomechanical resonator | A micromembrane mechanical resonator was fabricated from stoichiometric silicon nitride. Its resonant motion was actuated using an electrical field gradient force generated by electrodes adjacent to the oscillating structure, eliminating the need for electrodes directly on the movable membrane, thereby preserving a high-quality factor. This method enables investigation of multiple modes of the micromembrane, up to the 32nd mode with a resonant frequency of 78 MHz, using optical measurement technique. The absence of a substrate beneath the membrane makes the structure compatible with optical cavities. This compatibility is crucial for cavity-optomechanical systems, which require integration of mechanical devices with high-finesse optical cavities. Furthermore, by applying phase-shifted RF signals, symmetric modes at the similar resonant frequency can be separated and analyzed. The high-frequency and multi-mode operation, coupled with the substrate-free design makes this micromembrane resonator a promising candidate for applications in optical signal processing, optical component integration with high-finesse cavities, and exploration of cavity optomechanics. © The Korean Physical Society 2025. | Cho, Sungwan; Jo, Myunglae; Kim, Sanggoon; Park, Yun Daniel; Shim, Seung Bo | Korea Research Institute of Standards and Science, Daejeon, 34113, South Korea; Department of Physics and Astronomy, Seoul National University, Seoul, 08826, South Korea, Department of Physics, Kyungpook National University, Daegu, 41566, South Korea; Korea Research Institute of Standards and Science, Daejeon, 34113, South Korea, Institute of Basic Science for Underground Physics, Daejeon, 34126, South Korea; Department of Physics and Astronomy, Seoul National University, Seoul, 08826, South Korea; Korea Research Institute of Standards and Science, Daejeon, 34113, South Korea | 27171521100; 57221248150; 55811804900; 8081614600; 15763619700 | seungbo2@kriss.re.kr; parkyd@snu.ac.kr; | Journal of the Korean Physical Society | J KOREAN PHYS SOC | 0374-4884 | 1976-8524 | SCIE | PHYSICS, MULTIDISCIPLINARY | 2024 | 0.9 | 69.7 | 0 | 2025-06-11 | 0 | Electrical excitation; Mechanical resonator; MEMS; Optomechanics | Electric excitation; Microcavities; Optical phase conjugation; Optical signal processing; Oscillators (mechanical); Electrical excitation; Fully integrated; High frequency HF; Mechanical resonators; Micromembranes; Multimodes; On chips; Opto-mechanics; Optomechanical; Resonant motions; Micromechanical resonators | English | Article in press | 2025 | 10.1007/s40042-025-01368-9 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Properties of multifractality in time series of the Sun's magnetic parameters | The magnetic field in solar active regions (ARs) evolves dynamically and can play an important role in triggering solar flares as one of the Sun's major eruptive phenomena. It is, therefore, crucial to better understand the time-varying magnetic field in ARs in relation to flare occurrence. Here we applied the multifractal detrended fluctuation analysis (MF-DFA) method to time series of various magnetic parameters derived from the observed magnetic field in the photospheric surface of a total of 236 ARs consisting of 118 flare-quiet and 118 flaring cases. As a result, the nature of multifractality in various levels was identified in all the investigated time series of solar magnetic parameters. Comparing properties of multifractality in the time series of the flare-quiet versus flaring ARs, we first found that the magnetic parameter time series of the flaring ARs tend to have a higher generalized Hurst exponent than those of the flare-quiet ARs. Through the Student's t-test, it was also found that the distribution of generalized Hurst exponents is statistically different between the magnetic parameter time series of the flare-quiet and flaring ARs. In addition, for most of the magnetic parameters under investigation, the multifractal spectra derived from the relevant time series exhibit a higher degree of left truncation in the case of the flare-quiet ARs compared to the flaring ARs. These results support the fact reported in previous studies that the magnetic field in flaring ARs is more dynamic in terms of its rapid and large variations prior to and around times of flare occurrence. We expect that further detailed analysis of multifractality in time series of the Sun's various physical quantities not only in the photosphere but also in the upper atmosphere may help us to better understand the fundamental physics of solar eruptive phenomena. | Lee, Eo-Jin; Park, Sung-Hong | Kyungpook Natl Univ, Dept Astron & Atmospher Sci, Daegu 41566, South Korea; Seoul Natl Univ Educ, Dept Sci Educ, Seoul 06639, South Korea; Korea Astron & Space Sci Inst, Daejeon 34055, South Korea; Univ Sci & Technol, Dept Astron & Space Sci, Daejeon, South Korea | Park, Sung-Hong/B-3393-2012 | 57204929516; 25522250400 | eo-jin.lee@knu.ac.kr; | JOURNAL OF THE KOREAN PHYSICAL SOCIETY | J KOREAN PHYS SOC | 0374-4884 | 1976-8524 | 86 | 5 | SCIE | PHYSICS, MULTIDISCIPLINARY | 2024 | 0.9 | 69.7 | 0 | 2025-05-07 | 0 | 0 | Solar active regions; Solar flares; Multifractal detrended fluctuation analysis | DETRENDED FLUCTUATION ANALYSIS; SOLAR ACTIVE REGIONS; FLARE-QUIET | Multifractal detrended fluctuation analysis; Solar active regions; Solar flares | Aspherics; Magnetosphere; Solar irradiance; Active regions; Flaring active; Magnetic parameters; Magnetic-field; Multifractal detrended fluctuation analysis; Multifractality; Property; Solar active regions; Solar flare; Times series; Fractals | English | 2025 | 2025-03 | 10.1007/s40042-025-01293-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Strong electron-occupancy dependence of the lever arm in few-electron quantum dot systems | We quantitatively investigated the variation of gate lever-arm (α) in quantum dot (QD) systems, focusing on its dependence on electron occupancy. The values of α were obtained from Coulomb diamond measurements in a single quantum dot (SQD) and from the analysis of bias triangles near triple points in a double quantum dot (DQD) under finite DC bias. Utilizing charge sensor (CS) enabled clear detection of charge transitions even at low electron occupancies, revealing that the α increases substantially as the electron number decreases. For the SQD, α increased from 28meV/V with six electrons to 48meV/V in the single-electron regime − nearly 70% relative change − indicating enhanced sensitivity of QD energy levels to gate voltages. The electrostatic potential simulations further support this observation by showing that stronger electrostatic confinement, which leads to smaller QD dimensions, reduces electron occupancy and improves the controllability of energy levels via gate tuning. These findings highlight the importance of precise α estimation for controlling QD energy levels, with implications for potential applications in QD-based qubit manipulations and charge sensing in scalable quantum devices. © The Korean Physical Society 2025. | Kim, Uhjin; Lee, Seokyeong; Jo, Myunglae; Choi, Hyung Kook | Department of Physics, Research Institute of Physics and Chemistry, Jeonbuk National University, Jeonju, 54896, South Korea; Department of Physics, KAIST, Daejeon, 34141, South Korea; Department of Physics, Kyungpook National University, Daegu, 41566, South Korea; Department of Physics, Research Institute of Physics and Chemistry, Jeonbuk National University, Jeonju, 54896, South Korea | 57219216840; 57219689954; 57221248150; 55478370100 | hkchoi@jbnu.ac.kr; | Journal of the Korean Physical Society | J KOREAN PHYS SOC | 0374-4884 | 1976-8524 | SCIE | PHYSICS, MULTIDISCIPLINARY | 2024 | 0.9 | 69.7 | 0 | 2025-06-11 | 0 | Charge sensing; Double quantum dot; Lever-arm; Quantum dot | Electrostatic devices; Qubits; Charge sensing; Coulomb diamonds; Diamond measurements; Double quantum dots; Electron occupancy; Energy; Lever arm; Quantum dot; Quantum dot systems; Single quantum dot; Coulomb interactions | English | Article in press | 2025 | 10.1007/s40042-025-01388-5 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Causative Activities and Prognostic Factors of Open-Globe Injury: A Registry-Based City-Wide Multicentre Study | PurposeTraumatic globe injury is classified into closed-globe and open-globe injury (OGI); OGI leads to a worse prognosis. We aimed to identify causative activities and prognostic factors of OGI in a metropolitan city in South Korea.MethodsThis retrospective observational study used a prospective eye-injury registry conducted in Daegu, South Korea, between 1 August 2016 and 31 July 2021. We identified epidemiology and visual outcomes of OGI at four tertiary hospitals. Those with the best visual acuity lower than counting fingers at the 6-month follow-up were considered to have poor visual outcome.ResultsOf 9,208 patients with eye injuries, 282 had OGI. Most OGI patients were male (261, 92.6%), with the largest proportion in their 50s (76, 27.0%). The most frequent causative activity was mowing (59, 20.9%), and poor visual outcome was most seen in assault (7, 87.5%) and sports activity (9, 81.8%). Hammering, metal work, and sports activity were prevalent in those under 30, and mowing was most prevalent in those in their 50s (16, 21.1%) and 60s (29, 40.3%). In the multivariable logistic regression analysis, OGI related to traffic accident and sports activity were presented poor prognosis (adjusted odds ratio [aOR] 13.259, 95% confidence interval [CI] 1.202-146.205 for traffic accident; aOR 6.801, 95% CI 1.064-43.487 for sports activity).ConclusionWe need to develop advanced vehicle safety equipment, implement public education promoting seat belt usage and hazards of OGI, establish eye protection standards for key causal activities, and provide eye protection equipment for sports activities and mowing. | Kim, Jung Ho; Ryoo, Hyun Wook; Kim, Jong-Yeon; Ahn, Jae Yun; Moon, Sungbae; Jung, Haewon; Nho, Woo Young | Yeungnam Univ, Coll Med, Dept Emergency Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Emergency Med, 130 Dongdeok ro, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Publ Hlth & Med Off, Daegu, South Korea | Kim, Jungho/LDE-9088-2024; Nho, Woo Young/JLN-0752-2023; Ahn, Jae Yun/N-2652-2017; Kim, Jung Ho/LDE-9088-2024; Moon, Sungbae/F-4010-2015 | 57205704177; 55350557500; 58382951500; 56937505400; 57191584601; 57221554827; 57215831839 | ryoo@knu.ac.kr; | OPHTHALMIC EPIDEMIOLOGY | OPHTHAL EPIDEMIOL | 0928-6586 | 1744-5086 | 32 | 2 | SCIE | OPHTHALMOLOGY | 2024 | 1.2 | 69.9 | 5.99 | 2025-05-07 | 2 | 2 | Epidemiology; eye injuries; open-globe injuries; outcomes; prognostic factors | EYE INJURIES; EPIDEMIOLOGIC CHARACTERISTICS; RISK-FACTORS; TRAUMA; OUTCOMES | Epidemiology; eye injuries; open-globe injuries; outcomes; prognostic factors | Adolescent; Adult; Aged; Child; Child, Preschool; Eye Injuries, Penetrating; Female; Humans; Male; Middle Aged; Prognosis; Prospective Studies; Registries; Republic of Korea; Retrospective Studies; Risk Factors; Visual Acuity; Young Adult; adult; age; aged; Article; assault; clinical outcome; confidence interval; eye injury; eye protection; female; follow up; groups by age; hospital visit; human; major clinical study; male; metropolitan area; middle aged; multivariate logistic regression analysis; observational study; odds ratio; open globe injury; prevalence; prognosis; register; retrospective study; sex; South Korea; sport; tertiary care center; time; traffic accident; vehicle safety; vision; visual acuity; adolescent; child; clinical trial; epidemiology; multicenter study; penetrating eye injury; preschool child; prognosis; prospective study; risk factor; South Korea; visual acuity; young adult | English | 2025 | 2025-03-04 | 10.1080/09286586.2024.2372051 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Genetic diversity and structure of Persicaria amphibia (Polygonaceae) in South Korea using genotyping by sequencing | Background Persicaria amphibia, a member of the Polygonaceae family, exists both aquatic and terrestrial forms. It is native to North America, Asia, Europe, and some parts of Africa. Objective This study aimed to determine the genetic diversity within and among populations of P. amphibia and the distribution characteristics of each population to investigate insights into the genetic structure and conservation of P. amphibia. Methods In this study, the genetic diversity and structure of 84 P. amphibia individuals from 7 populations in South Korea were analyzed using genotyping-by-sequencing (GBS). We used 2,469 single nucleotide polymorphisms (SNPs) to analyze genetic diversity, principal components, structure, and phylogeny. Results Our results showed a mean observed heterozygosity and mean expected heterozygosity of 0.34409 and 0.34082, respectively. Genetic diversity analysis indicated that the variation among populations (60.08%) was greater than that within populations (39.92%). Fixation index values, principal components analysis, structure, and phylogeny analyses showed that the population in Gyodongdo, Ganghwa Island was highly different. Conclusion These results provide important insights for better understand the population history and genetic structure of P. amphibia. | Choi, KyoungSu; Hwang, Yong; Hong, Jeong-Ki; Park, So Young | Kyungpook Natl Univ, Coll Nat Sci, Dept Biol, Daegu 41566, South Korea; Nakdonggang Natl Inst Biol Resources, Divers Conservat Res Dept, Biol Specimen Conservat Div, Sangju 37242, South Korea; Nakdonggang Natl Inst Biol Resources, Adm Management Dept, Facil Management Div, Sangju 37242, South Korea | 59510703100; 57223012097; 58727220000; 59879430200 | choiks010@knu.ac.kr; | GENES & GENOMICS | GENES GENOM | 1976-9571 | 2092-9293 | 47 | 1 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;GENETICS & HEREDITY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 1.7 | 69.9 | 0 | 2025-05-07 | 0 | 0 | Persicaria amphibia; GBS; Genetic diversity; Population structure; Phylogenetic relationships | POPULATION-STRUCTURE; WEED; L. | GBS; Genetic diversity; Persicaria amphibia; Phylogenetic relationships; Population structure | Genetic Variation; Genotype; Genotyping Techniques; Phylogeny; Polymorphism, Single Nucleotide; Republic of Korea; Africa; Amphibia; article; controlled study; epidemiology; Europe; gene structure; genetic variability; genetic variation; genotype; genotyping; heterozygosity; nonhuman; North America; Persicaria; phylogeny; Polygonaceae; population structure; principal component analysis; single nucleotide polymorphism; South Korea; genetic variation; genotype; genotyping; procedures; single nucleotide polymorphism; South Korea | English | 2025 | 2025-01 | 10.1007/s13258-024-01571-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | In silico screening of epitopes as potential vaccine candidates against pathogenic Acinetobacter baumannii | Background: Multidrug-resistant (MDR) Acinetobacter baumannii (A. baumannii) poses a pressing threat to global healthcare settings, as most antibiotics are ineffective against this nosocomial pathogen. Vaccines, particularly peptide-based vaccines, offer a promising and effective strategy to deal with these infections. Objective: This study aimed to evaluate the potential of epitopes derived from the OmpA protein of A. baumannii as vaccine candidates for combating this pathogen. Methods: This study employed advanced bioinformatic tools to identify potential epitopes for vaccine candidates against A. baumannii infections. IEDB and SYFPEITHI were used to identify T-cell epitopes of A. baumannii OmpA protein. The epitopes were filtered based on score, clustering, human similarity, immunogenicity, cytokine response, and safety. Epitopes with high scores and both class-I and class-II sites were selected. Three epitopes were chosen for molecular docking and physicochemical evaluation as potential vaccine candidates. Results: Three epitopes (EP1, EP2, and EP3) derived from A. baumannii OmpA were found to effectively bind with specific human leukocyte antigen (HLA) alleles. These epitopes have shown promising potential to elicit both cellular and humoral immune responses. Their physicochemical and immunological properties were thoroughly evaluated, indicating strong antigenic potential, non-toxicity, lack of allergenic properties, good binding affinity, and wide population coverage. The epitopes’ two- and three-dimensional structures were predicted, and they were docked with their respective HLA alleles to assess their ability to stimulate innate immune responses. The predicted epitopes and HLA-allelic complexes exhibited excellent binding affinity, optimal Root Mean Square Deviation (RMSD) values, favorable physicochemical properties, and high-quality structural characteristics. Conclusions: This study identified epitopes that hold promise as potential solutions for combating multidrug-resistant A. baumannii, pending validation through wet lab experiments and clinical trials. © The Author(s) under exclusive licence to The Genetics Society of Korea 2025. | Islam, Md. Minarul; Han, Kyudong; Bang, Ye-Ji; Lee, Je Chul; Shin, Woo Shik; Oh, Man Hwan | Smart Animal Bio Institute, Dankook University, Cheonan, 31116, South Korea, Department of Microbiology, College of Bio-convergence, Dankook University, Cheonan, 31116, South Korea; Smart Animal Bio Institute, Dankook University, Cheonan, 31116, South Korea, Department of Microbiology, College of Bio-convergence, Dankook University, Cheonan, 31116, South Korea, Center for Bio-Medical Engineering Core Facility, Dankook University, Cheonan, 31116, South Korea, Department of Bio-convergence Engineering, Dankook University, Yongin, 16890, South Korea; Department of Biomedical Science, Seoul National University College of Medicine, Seoul, 03080, South Korea, Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, 03080, South Korea, Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul, 03080, South Korea; Department of Microbiology, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, 44272, OH, United States; Smart Animal Bio Institute, Dankook University, Cheonan, 31116, South Korea, Department of Microbiology, College of Bio-convergence, Dankook University, Cheonan, 31116, South Korea, Center for Bio-Medical Engineering Core Facility, Dankook University, Cheonan, 31116, South Korea | 57402857100; 9249290400; 55523614500; 25930392000; 57203789140; 59919681800 | yy1091@dankook.ac.kr; wshin@neomed.edu; | Genes and Genomics | GENES GENOM | 1976-9571 | 2092-9293 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;GENETICS & HEREDITY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 1.7 | 69.9 | 0 | Bioinformatics; Epitope; Human leukocyte antigen; Outer membrane proteins; Vaccine | English | Article in press | 2025 | 10.1007/s13258-025-01656-5 | 바로가기 | 바로가기 | 바로가기 | ||||||||||||
| ○ | ○ | Article | The facilitated osteogenic differentiation by extracellular proline treatment in in vitro cell cultivation using MC3T3E1 and hPDLF | Proline is a major substrate in collagen biosynthesis and is required for collagen molecule formations. However, detailed explanations of the molecular basis through which proline functions in collagen biosynthesis have yet to be provided. Thus, genome-wide screening was employed to elucidate these in the pre-osteoblastic MC3T3-E1 and human periodontal ligament fibroblast (hPDLF) cell lines. Indeed, both cell lines represent important sources for collagen biosynthesis and tissue regeneration in the dental region, specifically treating extracellular proline during cultivations. The altered gene expression patterns were identified, and the precise expression patterns were confirmed by microarray. Cell viability and osteogenic differentiation patterns were examined using a range of experimental methods, such as the MTS assay, ALP staining, ARS staining, and collagen (COL)-type1A ELISA. Overall, we revealed a cell line-specific function of exogenous proline in collagen biosynthesis during osteogenic differentiation conditions with the candidate signaling pathways. These putative signaling networks could represent plausible answers to understanding collagen biosynthesis for regenerating connective tissues such as skin, muscle, and bone. | Son, Sung-Ho; Kim, Anna; Jang, Je-Hee; Pokharel, Elina; Rana, Bandana; Kim, Tae-Young; Lee, Jae-Hee; An, Seo-Young; An, Chang-Hyeon; Park, Kwang-Kyun; Kwon, Tae-Yub; Kim, Jae-Young; Sohn, Wern-Joo | Kyungpook Natl Univ, Sch Dent, Dept Biochem, IHBR, Daegu, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral & Maxillofacial Radiol, IHBR, Daegu, South Korea; Yonsei Univ, Coll Dent, Dept Oral Biol, Seoul, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Dent Biomat, Daegu, South Korea; Daegu Haany Univ, Coll K Biohlth, Gyongsan, South Korea | 59416795800; 58112989700; 35749968600; 57220028220; 59130063600; 57208461628; 59416931600; 55258203200; 59510785000; 57214310459; 7202206084; 56812734700; 44161404800 | jykim91@knu.ac.kr; wjsohn@dhu.ac.kr; | GENES & GENOMICS | GENES GENOM | 1976-9571 | 2092-9293 | 47 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;GENETICS & HEREDITY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 1.7 | 69.9 | 0 | 2025-05-07 | 0 | 0 | Collagen biosynthesis; Proline; Osteogenic differentiation; Genome-wide screening; TCA cycle | COLLAGEN | Collagen biosynthesis; Genome-wide screening; Osteogenic differentiation; Proline; TCA cycle | Animals; Cell Differentiation; Cell Line; Collagen Type I; Fibroblasts; Humans; Mice; Osteoblasts; Osteogenesis; Periodontal Ligament; Proline; Signal Transduction; collagen; proline; collagen type 1; Article; bone development; cell culture; cell differentiation; cell viability; collagen synthesis; connective tissue; controlled study; enzyme linked immunosorbent assay; fibroblast; gene expression; human; human cell; in vitro study; MC3T3-E1 cell line; microarray analysis; MTS assay; periodontal ligament; signal transduction; tissue regeneration; animal; cell line; cytology; genetics; metabolism; mouse; osteoblast | English | 2025 | 2025-02 | 10.1007/s13258-024-01588-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A Lumped Magnetic-Circuit-Model-Based Analysis Method for Surface Permanent-Magnet Machines with Rotor Step-Skewing and Overhang | This study proposes a new analysis method based on lumped magnetic-circuit model for surface permanent-magnet machines with rotor step-skewing and overhang. The rotor step-skewing technique produces lower torque pulsation and sinusoidal back-EMF. In addition, an overhang structure having an extra rotor magnet in the axial direction provides enhanced torque and high power density. However, the three-dimensional (3-D) phenomena observed in the axial leakage flux between the skewed steps and the linkage flux owing to extra overhang magnet requires a 3D finite element method (FEM), which needs a considerable computation time and memory. To deal with this problem, a new equivalent lumped magnetic-circuit model for each rotor step considering the axial leakage flux between the steps and the linkage flux by the overhang is introduced. In addition, a new virtual remanence originating from the lumped circuit models is derived for each rotor step. The validity of the proposed method is verified by comparing a two-dimensional and 3D FEM of skewed, non-skewed, overhang, and non-overhang machines. | Kim, Rae-Eun; Kim, Jin-Seok; Kang, Jae-Woo; Seo, Jangho | Kyungpook Natl Univ, Sch Automot Engn, Sangju 37224, South Korea; Seoul Natl Univ, Dept Elect & Comp Engn, Seoul 08826, South Korea; Korea Elect Technol Inst, Intelligent Mechatron Res Ctr, Bocheon 14502, South Korea | 57189235125; 59240091700; 59239560700; 12791073600 | kre2567@keti.re.kr; jinseok.kim@keti.re.kr; jwkang12@keti.re.kr; j.seo@knu.ac.kr; | JOURNAL OF ELECTRICAL ENGINEERING & TECHNOLOGY | J ELECTR ENG TECHNOL | 1975-0102 | 2093-7423 | 20 | 3 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2024 | 1.6 | 70.4 | 0 | 2025-05-07 | 0 | 0 | 3D finite element method (FEM); Overhang; Rotor step-skew; Surface permanent magnet machines | COGGING TORQUE; DESIGN; COEFFICIENT | 3D finite element method (FEM); Overhang; Rotor step-skew; Surface permanent magnet machines | Electromagnetic induction; Flux linkage; Galvanomagnetic effects; Lumped parameter networks; Magnetic circuits; Magnetic leakage; Magnetic logic devices; Magnetic recording; Magnetic storage; Remanence; Rotors; 3-D finite elements; 3d finite element method; Analysis method; Element method; Lumped magnetic circuits; Magnetic circuit model; Overhang; Rotor step-skew; Step skews; Surface permanent magnet machines; Permanent magnets | English | 2025 | 2025-03 | 10.1007/s42835-024-02090-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | DC Partial Discharge Characteristics of MI Cable Model with Butt-Gap Structure | In this paper, to figure out the possibility of partial discharge diagnostics for HVDC MI submarine cables, and Mass Impregnated (MI) cable model was designed, and patterns and pulse waveforms of DC PD (Direct Current Partial Discharge) until the insulation breakdown were measured and analyzed. To verify the reliability of the experiment, partial discharges of the single void model and surface discharge model were also measured for comparison. As a result, the DC PD of the MI cable model showed that the discharge magnitude continuously increased as the applied voltage increased, but the discharge frequency significantly decreased as the ratio of overlapped or consecutive pulses increased, unlike the single void model. The occurrence of overlapping or consecutive pulses was interpreted as the discharges occurring when one butt-gap discharge triggered an adjacent butt-gap discharge, thereby bridging the butt gaps. Because overlapped or consecutive pulses had long durations and low-frequency components, it is expected that partial discharge pulses propagated over long distances could be measured even at the termination of submarine cables. The PSA (Pulse Sequence Analysis) for DC PD of the MI cable model showed as a void discharge pattern similar to that of the single void model, and it is expected that it can be distinguished from the surface discharge and converter noises. | Won, Yonguk; Bae, Youngjun; Jeong, Minwoo; Kim, Jeongtae | Daejin Univ, Dept Elect Engn, Daejin, South Korea; Taihan Cable & Solut Co, Mat Res Team, Seoul, South Korea; Hanyang Univ, Dept Elect Engn, Hanyang, South Korea; Kyungpook Natl Univ, Dept Elect Engn, Kyungpook, South Korea | 59460457800; 59504190700; 59505247900; 57200185421 | ehddyd1103@naver.com; baeyj0504@naver.com; jjjj322@naver.com; jtkim@daejin.ac.kr; | JOURNAL OF ELECTRICAL ENGINEERING & TECHNOLOGY | J ELECTR ENG TECHNOL | 1975-0102 | 2093-7423 | 20 | 5 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2024 | 1.6 | 70.4 | 0 | 2025-05-07 | 0 | 0 | MI submarine cables; DC PD; Butt-gap; Cavitation; Void discharge; Surface discharge; Pulse sequence analysis | Butt-gap; Cavitation; DC PD; MI submarine cables; Pulse sequence analysis; Surface discharge; Void discharge | HVDC power transmission; Partial discharges; Surface discharges; Underwater equipment; Butt gaps; Cable model; DC PD; Gap structures; Mass impregnated submarine cable; Partial discharge characteristics; Pulse sequence analysis; Submarine-cables; Void discharge; Void models; Submarine cables | English | 2025 | 2025-07 | 10.1007/s42835-025-02223-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Hardware-Efficient Quantized Stochastic Computing With Reduced Precision Stochastic Number Generator and LFSR-Based Counter | Stochastic computing (SC) is an emerging computing paradigm that offers excellent hardware efficiency and error tolerance. However, adopting SC in practical applications is not straightforward but faces serious challenges. In particular, a considerable overhead is imposed by the conversion between binary number and stochastic counterpart, which is usually performed by a stochastic number generator (SNG) and a binary counter. In this paper, we address this overhead issue by introducing a novel quantized SC architecture that shrinks the SNG hardware complexity significantly and a new approximate binary counter. To do this, we quantize binary numbers for SNGs to lower precision counterparts through several bit truncation schemes, which leads to an SNG overhead reduction. Also, we exploit a small-sized linear feedback shift register (LFSR) in the binary counter design to reduce its hardware resource consumption. When implemented in a 65-nm CMOS technology, the proposed quantized SNG and approximate binary counter reduce area and power by up to 68.3% and 80.6%, respectively, compared to the conventional full-precision SNG with an accurate counter. In addition, the proposed SC architecture with the LFSR-based counter does not deteriorate the stochastic computation accuracy beyond a certain degree of quantization. Besides, we demonstrate that the proposed SC schemes negligibly impact on processing quality with remarkably improved hardware efficiency by adopting it in a digital image processing application. © 2025 John Wiley & Sons Ltd. | Lee, Donghui; Kim, Yongtae | School of Computer Science and Engineering, Kyungpook National University, Daegu, South Korea; School of Computer Science and Engineering, Kyungpook National University, Daegu, South Korea | 57266466900; 55699627900 | yongtae@knu.ac.kr; | International Journal of Circuit Theory and Applications | INT J CIRC THEOR APP | 0098-9886 | 1097-007X | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2024 | 1.6 | 70.4 | 0 | bit truncation; comparator; counter; linear feedback shift register (LFSR); quantization; stochastic computing; stochastic number generator | Computer architecture; Computer hardware; Counting circuits; Efficiency; Feedback; Number theory; Random number generation; Binary counters; Bit truncation; Counter; Linear feedback shift register; Linear feedback shift registers; Number generator; Quantisation; Stochastic computing; Stochastic number generator; Stochastic numbers; Stochastic systems | English | Article in press | 2025 | 10.1002/cta.70041 | 바로가기 | 바로가기 | 바로가기 | |||||||||||
| ○ | ○ | Article | Claudin 18.2 Expression in Gastric Tumors and Other Tumor Types With Gastric Epithelium-like Differentiation | Background/Aim: Claudin 18.2 is an emerging biomarker for claudin 18.2-targeted therapy. We investigated claudin 18.2 expression in diverse tumor types. Patients and Methods: We retrospectively analyzed 67 gastric tumors (61 surgically resected and six biopsy specimens) and 73 other tumor types (69 resected and four biopsy specimens), including those from the pancreas, hepatobiliary system, lung, ovary, uterine cervix, and others. Claudin 18.2 expression and positivity (>= 75% of tumor cells showing moderate to strong membranous staining) were assessed using claudin 18 immunostaining (clone 43-14A). Results: Claudin 18.2 positivity was found in 47.8% (32/67) of gastric tumor samples. Epstein-Barr virus-associated gastric cancer showed a higher frequency of positivity (6/7, 85.7%), although not statistically significantly (p=0.216). Among gastric tumors from patients with lymph node or distant metastasis (n=20), four (20.0%) exhibited discrepancies in claudin 18.2 positivity between the primary and its metastasis. In other tumor types, claudin 18.2 positivity was more frequent in those with gastric epithelium-like differentiation, including pancreatic tumors (2/9, 22.2%), hepatobiliary carcinoma (2/8, 25.0%), invasive mucinous lung adenocarcinoma (4/5, 80.0%), and mucinous ovarian tumor (5/5, 100.0%) than in those with other histology (p<0.001). Interestingly, pancreatic tumors, potential candidates for claudin 18.2-targeted therapy, often exhibited reduced or lack of claudin 18.2 expression in the invasive component. Conclusion: Overall, claudin 18.2 positivity occurred primarily in a significant proportion of gastric tumors and other tumors with gastric epithelium-like differentiation. Evaluating claudin 18.2 expression in all such tumors can benefit patients by guiding targeted therapy. Additionally, claudin 18.2 immunostaining serves as a lineage marker for gastric origin or gastric-like differentiation. | Kim, Moonsik; Woo, Ha Young; Kim, Jinhee; Seo, An Na | Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu, South Korea; Chung Ang Univ, Gwangmyeong Hosp, Dept Pathol, Seoul, Gyeonggi Do, South Korea | 57195918515; 59754862600; 57789253600; 59149846900 | san0729@knu.ac.kr; | IN VIVO | IN VIVO | 0258-851X | 1791-7549 | 39 | 3 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2024 | 1.8 | 70.5 | N/A | 0 | 0 | Gastric cancer; claudin 18.2; claudin 18.2-positive tumors; clone 43-14A; zolbetuximab. | ABERRANT EXPRESSION; ADENOCARCINOMA; JUNCTION; TARGET | claudin 18.2; claudin 18.2‑positive tumors; clone 43‑14A; Gastric cancer; zolbetuximab | Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Cell Differentiation; Claudins; Female; Gastric Mucosa; Humans; Immunohistochemistry; Male; Middle Aged; Retrospective Studies; Stomach Neoplasms; claudin; claudin 18; zolbetuximab; claudin; CLDN18 protein, human; tumor marker; adult; Article; cell differentiation; cervical squamous cell carcinoma; colloid carcinoma; controlled study; distant metastasis; esophageal squamous cell carcinoma; female; hepatobiliary system; hepatobiliary system cancer; human; human tissue; immunohistochemistry; lung adenocarcinoma; lymph node; lymph node metastasis; lymphoma; major clinical study; male; neuroendocrine carcinoma; ovary carcinoma; ovary tumor; pancreas tumor; protein expression; retrospective study; squamous cell carcinoma; statistical analysis; stomach cancer; stomach epithelium; stomach tumor; thyroid papillary carcinoma; uterine cervix; uterine cervix adenocarcinoma; aged; genetics; metabolism; middle aged; pathology; stomach mucosa; stomach tumor; very elderly | English | 2025 | 2025 (MAY-JUN) | 10.21873/invivo.13954 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
페이지 이동: