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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Review | Host Subcellular Organelles: Targets of Viral Manipulation | Viruses have evolved sophisticated mechanisms to manipulate host cell processes and utilize intracellular organelles to facilitate their replication. These complex interactions between viruses and cellular organelles allow them to hijack the cellular machinery and impair homeostasis. Moreover, viral infection alters the cell membrane's structure and composition and induces vesicle formation to facilitate intracellular trafficking of viral components. However, the research focus has predominantly been on the immune response elicited by viruses, often overlooking the significant alterations that viruses induce in cellular organelles. Gaining a deeper understanding of these virus-induced cellular changes is crucial for elucidating the full life cycle of viruses and developing potent antiviral therapies. Exploring virus-induced cellular changes could substantially improve our understanding of viral infection mechanisms. | Song, Min Seok; Lee, Dong-Kun; Lee, Chung-Young; Park, Sang-Cheol; Yang, Jinsung | Gyeongsang Natl Univ, Inst Med Sci, Coll Med, Dept Physiol & Convergence Med Sci, Jinju 52727, South Korea; Kyungpook Natl Univ, Dept Microbiol, Sch Med, Daegu 41944, South Korea; Myongji Hosp, Artificial Intelligence & Robot Lab, Goyang 10475, South Korea; Gyeongsang Natl Univ, Inst Med Sci, Coll Med, Dept Biochem & Convergence Med Sci, Jinju 52727, South Korea | ; Yang, Jinsung/ABB-7722-2021; PARK, SANG/M-4617-2017 | 55931593700; 56555375200; 57195422071; 57042183900; 57211162448 | jyang@gnu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 3 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 0.51 | 2025-05-07 | 3 | 3 | virus; infection; organelles; endoplasmic reticulum; membrane; endocytosis; lysosome | ENDOPLASMIC-RETICULUM; VIRUS-REPLICATION; MITOCHONDRIAL FISSION; EXTRACELLULAR-MATRIX; ULTRASTRUCTURAL CHARACTERIZATION; RECEPTOR SPECIFICITY; MEMBRANE-VESICLES; NUCLEAR IMPORT; CELL ENTRY; PROTEIN | endocytosis; endoplasmic reticulum; infection; lysosome; membrane; organelles; virus | autophagosome; cell component; cell function; cell membrane; cell nucleus; cell organelle; cell structure; cytoskeleton; endocytosis; endoplasmic reticulum; exocytosis; exosome; extracellular matrix; host cell; human; lysosome; mitochondrion; nonhuman; Review; virus cell interaction; virus infection; virus replication | English | 2024 | 2024-02 | 10.3390/ijms25031638 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Identification of Quantitative Trait Loci Controlling Root Morphological Traits in an Interspecific Soybean Population Using 2D Imagery Data | Roots are the hidden and most important part of plants. They serve as stabilizers and channels for uptaking water and nutrients and play a crucial role in the growth and development of plants. Here, two-dimensional image data were used to identify quantitative trait loci (QTL) controlling root traits in an interspecific mapping population derived from a cross between wild soybean 'PI366121' and cultivar 'Williams 82'. A total of 2830 single-nucleotide polymorphisms were used for genotyping, constructing genetic linkage maps, and analyzing QTLs. Forty-two QTLs were identified on twelve chromosomes, twelve of which were identified as major QTLs, with a phenotypic variation range of 36.12% to 39.11% and a logarithm of odds value range of 12.01 to 17.35. Two significant QTL regions for the average diameter, root volume, and link average diameter root traits were detected on chromosomes 3 and 13, and both wild and cultivated soybeans contributed positive alleles. Six candidate genes, Glyma.03G027500 (transketolase/glycoaldehyde transferase), Glyma.03G014500 (dehydrogenases), Glyma.13G341500 (leucine-rich repeat receptor-like protein kinase), Glyma.13G341400 (AGC kinase family protein), Glyma.13G331900 (60S ribosomal protein), and Glyma.13G333100 (aquaporin transporter) showed higher expression in root tissues based on publicly available transcriptome data. These results will help breeders improve soybean genetic components and enhance soybean root morphological traits using desirable alleles from wild soybeans. | Islam, Mohammad Shafiqul; Ghimire, Amit; Lay, Liny; Khan, Waleed; Lee, Jeong-Dong; Song, Qijian; Jo, Hyun; Kim, Yoonha | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea; Noakhali Sci & Technol Univ, Dept Agr, Noakhali 3814, Bangladesh; USDA ARS, Soybean Genom & Improvement Lab, Beltsville Agr Res Ctr, Beltsville, MD 20705 USA; Kyungpook Natl Univ, Upland Field Machinery Res Ctr, Daegu 41566, South Korea | Song, Qijian/AGM-6556-2022; Islam, Mohammad/K-8232-2019; ghimire, amit/KCK-1842-2024 | 59448717500; 57823220200; 57766509400; 57822855200; 40462075100; 7202973814; 57194539358; 57224866763 | shafik.hort@gmail.com;ghimireamit2009@gmail.com;layliny22@gmail.com;waleedkhan.my@gmail.com;jdlee@knu.ac.kr;qijian.song@usda.gov;johyun@knu.ac.kr;kyh1229@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 9 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 1.13 | 2025-05-07 | 2 | 3 | soybean; root morphology; QTL mapping; average diameter (AD); root volume (RV); link average diameter (LAD); SNP; candidate genes | GLYCINE-MAX L.; ARCHITECTURAL TRAITS; MAPPING QTLS; GROWTH; YIELD; WHEAT; WATER; ADAPTATION; EXPRESSION; TOLERANCE | average diameter (AD); candidate genes; link average diameter (LAD); QTL mapping; root morphology; root volume (RV); SNP; soybean | Chromosome Mapping; Chromosomes, Plant; Genetic Linkage; Genotype; Glycine max; Phenotype; Plant Roots; Polymorphism, Single Nucleotide; Quantitative Trait Loci; 60S ribosomal protein L10; agc kinase family protein; aquaporin; leucine rich repeat protein; oxidoreductase; plant protein; transcriptome; transketolase; unclassified drug; allele; Article; cultivar; gene expression; gene expression level; genetic linkage; genomics; genotyping; morphological trait; nonhuman; phenotype; phenotypic variation; plant chromosome; plant gene; plant tissue; quantitative trait locus; root morphology; single nucleotide polymorphism; soybean; two-dimensional imaging; volume; wild plant; chromosomal mapping; genetics; genotype; growth, development and aging; plant root; procedures; single nucleotide polymorphism | English | 2024 | 2024-05 | 10.3390/ijms25094687 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Influence of N-Acetylglucosamine and Melatonin Interaction in Modeling the Photosynthetic Component and Metabolomics of Cucumber under Salinity Stress | The application of N-acetylglucosamine (GlcNAc) and melatonin (Mel) in agriculture could be a promising avenue for improving crop resilience and productivity, especially under challenging environmental conditions. In the current study, we treated the cucumber plant with GlcNAc and Mel solely and combinedly under salt stress (150 mM) then studied photosynthetic attributes using the transient OJIP fluorescence method. The results showed that the combination of GlcNAc x Mel significantly improved the plant morphological attributes, such as root and shoot biomass, and also improved chlorophyll and photosynthetic components. The mineral elements such as K, Mg, Ca, and P were significantly elevated, whereas a lower influx of Na was observed in GlcNAc x Mel treated cucumber shoots. A significant reduction in abscisic acid was observed, which was validated by the reduction in proline content and the increase in stomatal conductance (Gs), transpiration rate (E), and substomatal CO2 concentration (Ci). Furthermore, the activities of antioxidants such as polyphenol and flavonoid were considerably improved, resulting in a decrease in SOD and CAT with GlcNAc x Mel treatment. In addition, GlcNAc x Mel treatment dropped levels of the toxic radical Malondialdehyde (MDA) and elevated amino acids in cucumber shoots. These findings suggest that the combination of GlcNAc x Mel could be an effective elicitor for modeling plant metabolism to confer stress tolerance in crops. | Kang, Sang-Mo; Adhikari, Arjun; Kwon, Eun-Hae; Gam, Ho-Jun; Jeon, Jin Ryeol; Woo, Ji-In; Lee, In-Jung | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea | ; Gam, Hojun/MXJ-6421-2025; Adhikari, Arjun/AAV-6297-2021; Kang, Sang-Mo/MBG-7823-2025; Adhikari, Arjun/JCO-3306-2023; Lee, In-Jung/GLS-0432-2022 | 56189696900; 57195601415; 57224398710; 57450591400; 58781998600; 58295960600; 16425830900 | kmoya@hanmail.net;arjun@knu.ac.kr;eunhae.kwon1@gmail.com;jeff4237@gmail.com;98micael10@naver.com;wjxsj99@naver.com;ijlee@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 5 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 0 | 2025-05-07 | 1 | 1 | oxidative stress; chlorophyll fluorescence; environment; biostimulants; minerals | SALT-TOLERANCE; ANTIOXIDANT SYSTEMS; METABOLISM; RESPONSES; GROWTH; PLANTS; FLUX | biostimulants; chlorophyll fluorescence; environment; minerals; oxidative stress | Acetylglucosamine; Antioxidants; Cucumis sativus; Melatonin; Photosynthesis; Salinity; Salt Stress; amino acid; calcium ion; chlorophyll; flavonoid; magnesium ion; malonaldehyde; melatonin; n acetylglucosamine; polyphenol; potassium ion; antioxidant; n acetylglucosamine; Article; biomass; chlorophyll fluorescence; crop; cucumber; electron transport; evaluation study; fluorescence; fresh weight; metabolomics; model; nonhuman; photosynthesis; photosynthetic rate; physiological stress; plant leaf; plant metabolism; plant root; root length; salt stress; shoot; shoot length; stomatal conductance; sweating; water content; metabolism; photosynthesis; salinity; salt stress | English | 2024 | 2024-03 | 10.3390/ijms25052844 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Insights into How Plant-Derived Extracts and Compounds Can Help in the Prevention and Treatment of Keloid Disease: Established and Emerging Therapeutic Targets | Keloid is a disease in which fibroblasts abnormally proliferate and synthesize excessive amounts of extracellular matrix, including collagen and fibronectin, during the healing process of skin wounds, causing larger scars that exceed the boundaries of the original wound. Currently, surgical excision, cryotherapy, radiation, laser treatment, photodynamic therapy, pressure therapy, silicone gel sheeting, and pharmacotherapy are used alone or in combinations to treat this disease, but the outcomes are usually unsatisfactory. The purpose of this review is to examine whether natural products can help treat keloid disease. I introduce well-established therapeutic targets for this disease and various other emerging therapeutic targets that have been proposed based on the phenotypic difference between keloid-derived fibroblasts (KFs) and normal epidermal fibroblasts (NFs). We then present recent studies on the biological effects of various plant-derived extracts and compounds on KFs and NFs. Associated ex vivo, in vivo, and clinical studies are also presented. Finally, we discuss the mechanisms of action of the plant-derived extracts and compounds, the pros and cons, and the future tasks for natural product-based therapy for keloid disease, as compared with existing other therapies. Extracts of Astragalus membranaceus, Salvia miltiorrhiza, Aneilema keisak, Galla Chinensis, Lycium chinense, Physalis angulate, Allium sepa, and Camellia sinensis appear to modulate cell proliferation, migration, and/or extracellular matrix (ECM) production in KFs, supporting their therapeutic potential. Various phenolic compounds, terpenoids, alkaloids, and other plant-derived compounds could modulate different cell signaling pathways associated with the pathogenesis of keloids. For now, many studies are limited to in vitro experiments; additional research and development are needed to proceed to clinical trials. Many emerging therapeutic targets could accelerate the discovery of plant-derived substances for the prevention and treatment of keloid disease. I hope that this review will bridge past, present, and future research on this subject and provide insight into new therapeutic targets and pharmaceuticals, aiming for effective keloid treatment. | Boo, Yong Chool | Kyungpook Natl Univ, Dept Mol Med, Sch Med, 680 Gukchaebosang ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, BK21 Plus KNU Biomed Convergence Program, 680 Gukchaebosang ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, 680 Gukchaebosang ro, Daegu 41944, South Korea | 6602899130 | ycboo@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 0.77 | 2025-04-16 | 5 | 6 | keloid; transforming growth factor beta; TGF-beta; small mothers against decapentaplegic; SMAD; phenolic compounds; terpenoids; alkaloids; natural products; plant extracts | GROWTH-FACTOR-BETA; PULSED-DYE-LASER; COLLAGEN EXPRESSION; HYPERTROPHIC SCAR; EXTRACELLULAR-MATRIX; DOWN-REGULATION; ONION EXTRACT; TGF-BETA/SMAD; UP-REGULATION; CELL-CYCLE | alkaloids; keloid; natural products; phenolic compounds; plant extracts; SMAD; small mothers against decapentaplegic; terpenoids; TGF-β; transforming growth factor β | Cell Proliferation; Cells, Cultured; Collagen; Drugs, Chinese Herbal; Fibroblasts; Humans; Keloid; Plant Extracts; Tannins; activin; aldo keto reductase family 1 member B10; alkaloid; Allium sepa extract; Aneilema keisak extract; Astragalus extract; Galla chinensis extract; growth differentiation factor; high mobility group B1 protein; hypoxia inducible factor; immunoglobulin enhancer binding protein; inhibin; Janus kinase; Lycium extract; natural product; onion extract; phenol derivative; Physalis angulata extract; phytochemical; plant extract; prostaglandin E2; retinoic acid; retinoid; Salvia miltiorrhiza extract; silicone gel; sinecatechins; sphingosine 1 phosphate; STAT protein; steroid; terpenoid; transforming growth factor beta; unclassified drug; collagen; Galla chinensis; herbaceous agent; plant extract; tannin derivative; Allium; apoptosis; Astragalus membranaceus; biological activity; Camellia sinensis; cell migration; cell proliferation; collagen synthesis; epidermis; ex vivo study; extracellular matrix; fibroblast; human; in vitro study; in vivo study; keloid; Lycium chinense; nonhuman; pathogenesis; phenotype; photodynamic therapy; Physalis; Physalis angulata; radiation; Review; Salvia miltiorrhiza; signal transduction; Wnt signaling; cell culture; keloid; metabolism | English | 2024 | 2024-01 | 10.3390/ijms25021235 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Loss of SAV1 in Kidney Proximal Tubule Induces Maladaptive Repair after Ischemia and Reperfusion Injury | Kidney ischemia and reperfusion injury (IRI) is a significant contributor to acute kidney injury (AKI), characterized by tubular injury and kidney dysfunction. Salvador family WW domain containing protein 1 (SAV1) is a key component of the Hippo pathway and plays a crucial role in the regulation of organ size and tissue regeneration. However, whether SAV1 plays a role in kidney IRI is not investigated. In this study, we investigated the role of SAV1 in kidney injury and regeneration following IRI. A proximal tubule-specific knockout of SAV1 in kidneys (SAV1ptKO) was generated, and wild-type and SAV1ptKO mice underwent kidney IRI or sham operation. Plasma creatinine and blood urea nitrogen were measured to assess kidney function. Histological studies, including periodic acid-Schiff staining and immunohistochemistry, were conducted to assess tubular injury, SAV1 expression, and cell proliferation. Western blot analysis was employed to assess the Hippo pathway-related and proliferation-related proteins. SAV1 exhibited faint expression in the proximal tubules and was predominantly expressed in the connecting tubule to the collecting duct. At 48 h after IRI, SAV1ptKO mice continued to exhibit severe kidney dysfunction, compared to attenuated kidney dysfunction in wild-type mice. Consistent with the functional data, severe tubular damage induced by kidney IRI in the cortex was significantly decreased in wild-type mice at 48 h after IRI but not in SAV1ptKO mice. Furthermore, 48 h after IRI, the number of Ki67-positive cells in the cortex was significantly higher in wild-type mice than SAV1ptKO mice. After IRI, activation and expression of Hippo pathway-related proteins were enhanced, with no significant differences observed between wild-type and SAV1ptKO mice. Notably, at 48 h after IRI, protein kinase B activation (AKT) was significantly enhanced in SAV1ptKO mice compared to wild-type mice. This study demonstrates that SAV1 deficiency in the kidney proximal tubule worsens the injury and delays kidney regeneration after IRI, potentially through the overactivation of AKT. | Moon, Daeun; Padanilam, Babu J.; Park, Kwon Moo; Kim, Jinu | Jeju Natl Univ, Coll Med, Dept Anat, Jeju 63243, South Korea; Icahn Sch Med Mt Sinai, Tisch Canc Inst, Dept Urol, New York, NY 10029 USA; Kyungpook Natl Univ, Dept Anat, BK21 Plus, Daegu 41944, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Sch Med, Daegu 41944, South Korea; Jeju Natl Univ, Interdisciplinary Grad Program Adv Convergence Tec, Jeju 63243, South Korea | 57211064581; 6701470902; 8785448200; 16316045800 | qjxms9312@jejunu.ac.kr;babu.padanilam@mountsinai.org;kmpark@knu.ac.kr;jinu.kim@jejunu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 9 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 0.38 | 2025-05-07 | 1 | 1 | Hippo signaling pathway; salvador family WW domain containing protein 1; ischemia and reperfusion injury; kidney regeneration; protein kinase B | ACTIVATION; PATHWAY; STRESS; AKT; SUPPRESSION; MARKERS; MICE | Hippo signaling pathway; ischemia and reperfusion injury; kidney regeneration; protein kinase B; salvador family WW domain containing protein 1 | Acute Kidney Injury; Animals; Cell Cycle Proteins; Cell Proliferation; Disease Models, Animal; Hippo Signaling Pathway; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Reperfusion Injury; Signal Transduction; aquaporin 1; aquaporin 2; creatinine; phosphoprotein; protein kinase B; salvador family ww domain containing protein 1; sodium potassium chloride cotransporter 2; unclassified drug; urea; cell cycle protein; Sav1 protein, mouse; allele; animal cell; animal experiment; animal model; animal tissue; Article; cell proliferation; controlled study; creatinine blood level; gene knockout; genotyping; hippo signaling; immunohistochemistry; kidney function; kidney proximal tubule; kidney tubule cell; male; mouse; nonhuman; periodic acid Schiff stain; protein expression; renal ischemia reperfusion injury; severe renal impairment; transgenic mouse; urea nitrogen blood level; Western blotting; wild type; wild type mouse; acute kidney failure; animal; C57BL mouse; disease model; genetics; knockout mouse; metabolism; pathology; reperfusion injury; signal transduction | English | 2024 | 2024-05 | 10.3390/ijms25094610 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Map-Based Cloning and Characterization of a Major QTL Gene, FfR1, Which Confers Resistance to Rice Bakanae Disease | Bakanae disease (BD), caused by the fungal pathogen Fusarium fujikuroi, is a serious threat to rice production worldwide. Breeding elite rice varieties resistant to BD requires the identification of resistance genes. Previously, we discovered a resistant quantitative trait locus (QTL), qFfR1, in a Korean japonica rice variety, Nampyeong. In this study, we fine-mapped qFfR1 with a Junam(*4)/Nampyeong BC3F3 population and delimited its location to a 37.1 kb region on chromosome 1. Complementation experiments with seven candidate genes in this region revealed that OsI₀₂₇₂₈ is the gene for qFfR1. This gene encodes a protein with a typical leucine-rich repeat (LRR) receptor-like protein structure. RNA-sequencing-based transcriptomic analysis revealed that FfR1 induces the transcription of defense genes, including lignin and terpenoid biosynthesis genes, pathogenesis-related genes, and thionin genes. These results may facilitate investigations into the molecular mechanisms underlying BD resistance, including molecular patterns of Fusarium fujikuroi interacting with FfR1 and players working in signal transduction pathways downstream of FfR1, and the breeding of new BD-resistant varieties by providing a BD resistance gene with its precise selection marker. This will contribute to efficient control of BD, which is becoming more prevalent according to temperature rises due to climate change. | Ji, Hyeonso; Cheon, Kyeong-Seong; Shin, Yunji; Lee, Chaewon; Son, Seungmin; Oh, Hyoja; Yoon, Dong-Kyung; Lee, Seoyeon; Cho, Mihyun; Jun, Soojin; Lee, Gang-Seob; Baek, Jeongho; Kim, Song Lim; Ahn, Il-Pyung; Oh, Jae-Hyeon; Yoon, Hye-Jin; Cha, Young-Soon; Kim, Kyung-Hwan | Natl Inst Agr Sci, Rural Dev Adm RDA, Dept Agr Biotechnol, Jeonju 54874, South Korea; Natl Inst Forest Sci, Dept Forest Bioresources, Suwon 16631, South Korea; Natl Inst Crop Sci, Rural Dev Adm RDA, Dept Cent Area Crop Sci, Suwon 16429, South Korea; Natl Inst Crop Sci, Rural Dev Adm RDA, Dept Southern Area Crop Sci, Miryang 50424, South Korea; Kyungpook Natl Univ, Coastal Agr Res Inst, Daegu 41566, South Korea | Son, Seungmin/HPG-7193-2023; Oh, Jaehyeon/M-8847-2019; Kim, Kyung/J-5382-2012 | 7201738214; 57210674326; 57322985400; 57226406616; 57219332606; 57204877853; 57222643035; 58548063800; 59099653800; 58549047400; 25927158200; 57202406016; 16177967300; 7006536992; 57109658100; 56281185800; 9245082400; 57202965738 | jhs77@korea.kr;kscheon16@korea.kr;yunji.shin8@gmail.com;wowlek44@korea.kr;linewind@korea.kr;hja-oh@hanmail.net;dkyoon11@korea.kr;hklee0214@korea.kr;chomi1@korea.kr;jsoojin98@korea.kr;kangslee0227@gmail.com;firstleon@korea.kr;greenksl@korea.kr;jinhyung@korea.kr;jhoh8288@korea.kr;hyejinyoon@korea.kr;yscha63@korea.kr;biopiakim@korea.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 11 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 0.76 | 2025-05-07 | 2 | 3 | rice; bakanae disease; resistance; LRR-RLP; selection marker | FUSARIUM-FUJIKUROI; CLADOSPORIUM-FULVUM; RECOGNITIONAL SPECIFICITY; RECEPTOR; IDENTIFICATION; PATHOGENICITY; PROTEINS; IMMUNITY | bakanae disease; LRR-RLP; resistance; rice; selection marker | Chromosome Mapping; Chromosomes, Plant; Cloning, Molecular; Disease Resistance; Fusarium; Gene Expression Regulation, Plant; Oryza; Plant Diseases; Plant Proteins; Quantitative Trait Loci; green fluorescent protein; lignin; terpenoid; thionine; plant protein; Aegilops tauschii; Article; barley; biosynthesis; cell membrane; cellular distribution; chromosome 1; climate change; comparative study; controlled study; developmental stage; disease resistance; frameshift mutation; fungus growth; Fusarium fujikuroi; gene editing; gene expression; gene expression level; gene expression profiling; gene structure; genetic trait; genotype; genotyping; housekeeping gene; in vitro study; Japonica rice; Lolium rigidum; molecular cloning; multigene family; mycelial growth; nonhuman; Passalora fulva; pathogenesis; phenotype; progeny; protein structure; quantitative trait locus; real time polymerase chain reaction; RNA sequencing; signal transduction; single nucleotide polymorphism; tomato; Triticum aestivum; upregulation; chromosomal mapping; Fusarium; gene expression regulation; genetics; metabolism; microbiology; molecular cloning; Oryza; pathogenicity; plant chromosome; plant disease; quantitative trait locus | English | 2024 | 2024-06 | 10.3390/ijms25116214 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Melatonin-Nitric Oxide Crosstalk in Plants and the Prospects of NOMela as a Nitric Oxide Donor | Melatonin regulates vital physiological processes in animals, such as the circadian cycle, sleep, locomotion, body temperature, food intake, and sexual and immune responses. In plants, melatonin modulates seed germination, longevity, circadian cycle, photoperiodicity, flowering, leaf senescence, postharvest fruit storage, and resistance against biotic and abiotic stresses. In plants, the effect of melatonin is mediated by various regulatory elements of the redox network, including RNS and ROS. Similarly, the radical gas NO mediates various physiological processes, like seed germination, flowering, leaf senescence, and stress responses. The biosynthesis of both melatonin and NO takes place in mitochondria and chloroplasts. Hence, both melatonin and nitric oxide are key signaling molecules governing their biological pathways independently. However, there are instances when these pathways cross each other and the two molecules interact with each other, resulting in the formation of N-nitrosomelatonin or NOMela, which is a nitrosated form of melatonin, discovered recently and with promising roles in plant development. The interaction between NO and melatonin is highly complex, and, although a handful of studies reporting these interactions have been published, the exact molecular mechanisms governing them and the prospects of NOMela as a NO donor have just started to be unraveled. Here, we review NO and melatonin production as well as RNS-melatonin interaction under normal and stressful conditions. Furthermore, for the first time, we provide highly sensitive, ozone-chemiluminescence-based comparative measurements of the nitric oxide content, as well as NO-release kinetics between NOMela and the commonly used NO donors CySNO and GSNO. | Hussain, Adil; Faheem, Brekhna; Jang, Hyung-Seok; Lee, Da-Sol; Mun, Bong-Gyu; Rolly, Nkulu Kabange; Yun, Byung-Wook | Abdul Wali Khan Univ Mardan, Dept Agr, Mardan 23200, Pakistan; Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Appl Biosci, Daegu 41566, South Korea; Abdul Wali Khan Univ Mardan, Dept Zool, Mardan 23200, Pakistan; Chungbuk Natl Univ, Dept Environm & Biol Chem, Cheongju 28644, South Korea | ; Hussain, Adil/K-6016-2018; KABANGE, NKULU/AAQ-9425-2020; Hussain, Dr. Adil/K-6016-2018; Mun, BongGyu/GYD-6010-2022 | 41961162600; 57878653900; 59254504700; 57222624235; 57147241300; 57202031236; 8245123600 | adilhussain@awkum.edu.pk;bwyun@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 15 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 0.51 | 2025-05-07 | 6 | 5 | melatonin; NO; NOMela; NO release kinetics; ROS; RNS | NITROSATED TRYPTOPHAN DERIVATIVES; N-NITROSOMELATONIN; EXOGENOUS MELATONIN; STRESS TOLERANCE; INDUCED RELEASE; ABIOTIC STRESS; GROWTH; ANTIOXIDANT; METABOLISM; INHIBITION | melatonin; NO; NO release kinetics; NOMela; RNS; ROS | Melatonin; Nitric Oxide; Nitric Oxide Donors; Plant Physiological Phenomena; Plants; Signal Transduction; melatonin; nitric oxide donor; ozone; nitric oxide; nitric oxide donor; abiotic stress; biosynthesis; body temperature; chloroplast; circadian rhythm; controlled study; flowering; food intake; fruit storage; germination; immune response; kinetics; leaf senescence; locomotion; longevity; mitochondrion; nonhuman; photoperiodicity; plant development; postharvest period; review; signal transduction; metabolism; plant; plant physiology | English | 2024 | 2024-08 | 10.3390/ijms25158535 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Melatonin: The Multifaceted Molecule in Plant Growth and Defense | Melatonin (MEL), a hormone primarily known for its role in regulating sleep and circadian rhythms in animals, has emerged as a multifaceted molecule in plants. Recent research has shed light on its diverse functions in plant growth and defense mechanisms. This review explores the intricate roles of MEL in plant growth and defense responses. MEL is involved in plant growth owing to its influence on hormone regulation. MEL promotes root elongation and lateral root formation and enhances photosynthesis, thereby promoting overall plant growth and productivity. Additionally, MEL is implicated in regulating the circadian rhythm of plants, affecting key physiological processes that influence plant growth patterns. MEL also exhibits antioxidant properties and scavenges reactive oxygen species, thereby mitigating oxidative stress. Furthermore, it activates defense pathways against various biotic stressors. MEL also enhances the production of secondary metabolites that contribute to plant resistance against environmental changes. MEL's ability to modulate plant response to abiotic stresses has also been extensively studied. It regulates stomatal closure, conserves water, and enhances stress tolerance by activating stress-responsive genes and modulating signaling pathways. Moreover, MEL and nitric oxide cooperate in stress responses, antioxidant defense, and plant growth. Understanding the mechanisms underlying MEL's actions in plants will provide new insights into the development of innovative strategies for enhancing crop productivity, improving stress tolerance, and combating plant diseases. Further research in this area will deepen our knowledge of MEL's intricate functions and its potential applications in sustainable agriculture. | Khan, Murtaza; Hussain, Adil; Yun, Byung-Wook; Mun, Bong-Gyu | Yeungnam Univ, Dept Hort & Life Sci, Gyongsan 38541, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Abdul Wali Khan Univ Mardan, Dept Entomol, Mardan 23200, Pakistan; Chungbuk Natl Univ, Dept Environm & Biol Chem, Cheongju 28644, South Korea | Hussain, Dr. Adil/K-6016-2018; Mun, BongGyu/GYD-6010-2022; Hussain, Adil/K-6016-2018 | 57207990116; 41961162600; 8245123600; 57147241300 | munbg@cbnu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 12 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 0.86 | 2025-05-07 | 5 | 6 | melatonin; biosynthesis; plant growth; abiotic stress; biotic stress | EXOGENOUS APPLICATION; CARBOHYDRATE-METABOLISM; NITRIC-OXIDE; SALT STRESS; DROUGHT; ARABIDOPSIS; ACCUMULATION | abiotic stress; biosynthesis; biotic stress; melatonin; plant growth | Antioxidants; Circadian Rhythm; Gene Expression Regulation, Plant; Melatonin; Plant Development; Plant Growth Regulators; Plants; Stress, Physiological; antioxidant; melatonin; reactive oxygen metabolite; phytohormone; abiotic stress; biosynthesis; biotic stress; circadian rhythm; environmental change; hormonal regulation; lateral root; metabolite; nonhuman; oxidative stress; pharmacology; photosynthesis; physiological stress; plant disease; plant growth; plant response; plant root; review; signal transduction; gene expression regulation; metabolism; physiological stress; physiology; plant; plant development | English | 2024 | 2024-06 | 10.3390/ijms25126799 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | MicroRNA-135b-5p Is a Pathologic Biomarker in the Endothelial Cells of Arteriovenous Malformations | Arteriovenous malformations (AVMs) are congenital vascular anomalies with a poor prognosis. AVMs are considered intractable diseases, as there is no established approach for early diagnosis and treatment. Therefore, this study aimed to provide new evidence by analyzing microRNAs (miRNAs) associated with AVM. We present fundamental evidence for the early diagnosis and treatment of AVM by analyzing miRNAs in the endothelial cells of AVMs. This study performed sequencing and validation of miRNAs in endothelial cells from normal and AVM tissues. Five upregulated and two downregulated miRNAs were subsequently analyzed under hypoxia and vascular endothelial growth factor (VEGF) treatment by one-way analysis of variance (ANOVA). Under hypoxic conditions, miR-135b-5p was significantly upregulated in the AVM compared to that under normal conditions, corresponding to increased endothelial activity (p-value = 0.0238). VEGF treatment showed no significant increase in miR-135b-5p under normal conditions, however, a surge in AVM was observed. Under both hypoxia and VEGF treatment, comparison indicated a downregulation of miR-135b-5p in AVM. Therefore, miR-135b-5p was assumed to affect the pathophysiological process of AVM and might play a vital role as a potential biomarker of AVMs for application related to diagnosis and treatment. | Lee, Joon Seok; Kim, Gyeonghwa; Lee, Jong Ho; Ryu, Jeong Yeop; Oh, Eun Jung; Kim, Hyun Mi; Kwak, Suin; Hur, Keun; Chung, Ho Yun | Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu 41199, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Daegu 41944, South Korea | Kim, Gyeonghwa/AAQ-6424-2021; Hur, Keun/G-9513-2011; LEE, JIN/Q-3108-2018; Ryu, Jeong Yeop/GLQ-9419-2022 | 56496041000; 57195957884; 57212661146; 56366349400; 35746789300; 57261065200; 57735418300; 8861888000; 7404007181 | leejspo@knu.ac.kr;med.aurora1106@gmail.com;clerk0823@naver.com;rjyflying@naver.com;fullrest74@hanmail.net;sarang7939@naver.com;suin8349@naver.com;keunhur@knu.ac.kr;hy-chung@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 9 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 1.13 | 2025-05-07 | 3 | 3 | arteriovenous malformation; microRNA-135b-5p; endothelial cells | INDUCIBLE FACTOR-I; VASCULAR MALFORMATIONS; GROWTH-FACTOR; BLOOD-FLOW; MICRORNAS; VEGF; ANGIOGENESIS; PHYSIOLOGY; STRESS; TUMORS | arteriovenous malformation; endothelial cells; microRNA-135b-5p | Adult; Arteriovenous Malformations; Biomarkers; Cell Hypoxia; Endothelial Cells; Female; Humans; Male; MicroRNAs; Vascular Endothelial Growth Factor A; microRNA; microrna 135b 5p; unclassified drug; vasculotropin; biological marker; microRNA; MIRN135 microRNA, human; vasculotropin A; adolescent; adult; arteriovenous malformation; Article; child; clinical article; comparative study; down regulation; early diagnosis; endothelium cell; female; gene sequence; human; human cell; hypoxia; male; middle aged; mRNA expression level; preschool child; real time polymerase chain reaction; upregulation; young adult; cell hypoxia; genetics; metabolism; pathology | English | 2024 | 2024-05 | 10.3390/ijms25094888 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Natural Products in the Treatment of Retinopathy of Prematurity: Exploring Therapeutic Potentials | Retinopathy of prematurity (ROP) is a vascular disorder affecting the retinas of preterm infants. This condition arises when preterm infants in incubators are exposed to high oxygen levels, leading to oxidative stress, inflammatory responses, and a downregulation of vascular endothelial growth factors, which causes the loss of retinal microvascular capillaries. Upon returning to room air, the upregulation of vascular growth factors results in abnormal vascular growth of retinal endothelial cells. Without appropriate intervention, ROP can progress to blindness. The prevalence of ROP has risen, making it a significant cause of childhood blindness. Current treatments, such as laser therapy and various pharmacologic approaches, are limited by their potential for severe adverse effects. Therefore, a deeper understanding of ROP's pathophysiology and the development of innovative treatments are imperative. Natural products from plants, fungi, bacteria, and marine organisms have shown promise in treating various diseases and have gained attention in ROP research due to their minimal side effects and wide-ranging beneficial properties. This review discusses the roles and mechanisms of natural products that hold potential as therapeutic agents in ROP management. | Heo, Jong-Ik; Ryu, Juhee | Kyungpook Natl Univ, Coll Pharm, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu 41566, South Korea | 58881241500; 57208255566 | ik0412@knu.ac.kr;juheeryu@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 15 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 0.17 | 2025-05-07 | 1 | 1 | natural products; angiogenesis; retinopathy of prematurity; retinal vascular disease | ENDOTHELIAL GROWTH-FACTOR; OXYGEN-INDUCED RETINOPATHY; RETINAL NEOVASCULARIZATION; DRUG DISCOVERY; MOUSE MODEL; NADPH OXIDASE; ANTI-VEGF; RAT MODEL; ANGIOGENESIS; HYPOXIA | angiogenesis; natural products; retinal vascular disease; retinopathy of prematurity | Animals; Biological Products; Humans; Infant, Newborn; Infant, Premature; Retinopathy of Prematurity; natural product; vasculotropin; biological product; ambient air; angiogenesis; down regulation; drug therapy; endothelium cell; human; incubator; inflammation; nonhuman; oxidative stress; pathophysiology; pharmacology; prevalence; retinal vascular disease; retrolental fibroplasia; review; therapy; upregulation; vascular disease; vascularization; animal; metabolism; newborn; prematurity | English | 2024 | 2024-08 | 10.3390/ijms25158461 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Novel Amidine Derivative K1586 Sensitizes Colorectal Cancer Cells to Ionizing Radiation by Inducing Chk1 Instability | Checkpoint kinase 1 (Chk1) is a key mediator of the DNA damage response that regulates cell cycle progression, DNA damage repair, and DNA replication. Small-molecule Chk1 inhibitors sensitize cancer cells to genotoxic agents and have shown preclinical activity as single agents in cancers characterized by high levels of replication stress. However, the underlying genetic determinants of Chk1-inhibitor sensitivity remain unclear. Although treatment options for advanced colorectal cancer are limited, radiotherapy is effective. Here, we report that exposure to a novel amidine derivative, K1586, leads to an initial reduction in the proliferative potential of colorectal cancer cells. Cell cycle analysis revealed that the length of the G2/M phase increased with K1586 exposure as a result of Chk1 instability. Exposure to K1586 enhanced the degradation of Chk1 in a time- and dose-dependent manner, increasing replication stress and sensitizing colorectal cancer cells to radiation. Taken together, the results suggest that a novel amidine derivative may have potential as a radiotherapy-sensitization agent that targets Chk1. | Kim, Hang Soo; Park, Ji-Eun; Lee, Won Hyung; Kwon, Young Bin; Seu, Young-Bae; Kim, Kwang Seok | Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci, Daegu 41566, South Korea; Korea Inst Radiol & Med Sci, Div Radiat Biomed Res, Seoul 139706, South Korea; Univ Sci & Technol, Sch Radiol & Med Oncol Sci, Daejeon 34054, South Korea; Pharmicell Co Ltd, R&D Ctr, Chem Business Unit, Ulsan 45009, South Korea; Kyung Nong Co Ltd, Cent Res Inst, Gyeongju 38175, South Korea | 59006633800; 57431866400; 59006661500; 59006661600; 6602236684; 50461711800 | soo7532@hanmail.net;rr105014@kirams.re.kr;genius1982@nate.com;ybkwon@dongoh.co.kr;ybseu@knu.ac.kr;kskim@kirams.re.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 8 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 0 | 2025-05-07 | 0 | 0 | radiosensitizer; anticancer; Chk1; amidine-containing compound; replication stress | NEGATIVE BREAST-CANCER; DOWN-REGULATION; DNA; ANTICANCER; ATR; RADIOSENSITIVITY; DEGRADATION; ACTIVATION; CHECKPOINT; COMPLEX | amidine-containing compound; anticancer; Chk1; radiosensitizer; replication stress | Amidines; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; Colorectal Neoplasms; DNA Damage; DNA Replication; Humans; Radiation, Ionizing; Radiation-Sensitizing Agents; amidine; checkpoint kinase 1; CHEK1 protein, human; radiosensitizing agent; cell cycle; cell proliferation; colorectal tumor; DNA damage; DNA replication; drug effect; human; ionizing radiation; metabolism; pathology; tumor cell line | English | 2024 | 2024-04 | 10.3390/ijms25084396 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Reconstruction of Segmental Bone Defect in Canine Tibia Model Utilizing Bi-Phasic Scaffold: Pilot Study | The reunion and restoration of large segmental bone defects pose significant clinical challenges. Conventional strategies primarily involve the combination of bone scaffolds with seeded cells and/or growth factors to regulate osteogenesis and angiogenesis. However, these therapies face inherent issues related to immunogenicity, tumorigenesis, bioactivity, and off-the-shelf transplantation. The biogenic micro-environment created by implanted bone grafts plays a crucial role in initiating the bone regeneration cascade. To address this, a highly porous bi-phasic ceramic synthetic bone graft, composed of hydroxyapatite (HA) and alumina (Al), was developed. This graft was employed to repair critical segmental defects, involving the creation of a 2 cm segmental defect in a canine tibia. The assessment of bone regeneration within the synthetic bone graft post-healing was conducted using scintigraphy, micro-CT, histology, and dynamic histomorphometry. The technique yielded pore sizes in the range of 230-430 mu m as primary pores, 40-70 mu m as secondary inner microchannels, and 200-400 nm as tertiary submicron surface holes. These three components are designed to mimic trabecular bone networks and to provide body fluid adsorption, diffusion, a nutritional supply, communication around the cells, and cell anchorage. The overall porosity was measured at 82.61 +/- 1.28%. Both micro-CT imaging and histological analysis provided substantial evidence of robust bone formation and the successful reunion of the critical defect. Furthermore, an histology revealed the presence of vascularization within the newly formed bone area, clearly demonstrating trabecular and cortical bone formation at the 8-week mark post-implantation. | Haam, Dae-Won; Bae, Chun-Sik; Kim, Jong-Min; Hann, Sung-Yun; Yim, Chang-Min Richard; Moon, Hong-Seok; Oh, Daniel S. | Yonsei Univ, Coll Dent, Dept Prosthodont, Seoul 03722, South Korea; Chonnam Natl Univ, Coll Vet Med, Gwangju 61186, South Korea; Cheongju Univ, Coll Hlth & Med Sci, Cheongju 28503, South Korea; Kyungpook Natl Univ, Dept Precis Mech Engn, Sangju 37224, South Korea; Rutgers State Univ, Sch Dent Med, Newark, NJ 07102 USA; Yonsei Univ, Coll Dent, Dept Dent Biomat, Seoul 03722, South Korea | Hann, Sung Yun/HZM-2708-2023; Kim, Jong-Min/J-5435-2012 | 59126391800; 55779077300; 56151243800; 57207825277; 57457791100; 7402662548; 56226966400 | drhaamdds@gmail.com;csbae210@jnu.ac.kr;vinaka00@gmail.com;syhann@knu.ac.kr;richard.yim@rutgers.edu;hsm5@yuhs.ac;dso0301@yuhs.ac; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 9 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 0.38 | 2025-05-07 | 1 | 1 | segmental bone defect; canine model; hydroxyapatite; ceramic; scaffold; reconstruction | IN-VIVO; REGENERATION; VASCULARIZATION; MANAGEMENT; EXTREMITY; INJURIES; GRAFTS; REPAIR | canine model; ceramic; hydroxyapatite; reconstruction; scaffold; segmental bone defect | Animals; Bone Regeneration; Bone Substitutes; Bone Transplantation; Dogs; Durapatite; Osteogenesis; Pilot Projects; Porosity; Tibia; Tissue Scaffolds; X-Ray Microtomography; aluminum oxide; hydroxyapatite; adsorption; animal experiment; animal tissue; Article; body fluid; bone defect; bone density; bone development; bone graft; bone matrix; bone regeneration; bone remodeling; carcinogenesis; cell anchorage; controlled study; environment; immunogenicity; male; micro-computed tomography; nonhuman; ossification; pore size; pore size distribution; scanning electron microscopy; scintigraphy; tibia; trabecular bone; vascularization; X ray diffraction; animal; bone regeneration; bone transplantation; chemistry; diagnostic imaging; dog; pilot study; porosity; procedures | English | 2024 | 2024-05 | 10.3390/ijms25094604 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Resistance training modalities: comparative analysis of effects on physical fitness, isokinetic muscle functions, and core muscle biomechanics | Introduction This study aimed to evaluate the effects of varied resistance training modalities on physical fitness components, body composition, maximal strength assessed by one-repetition maximum (1RM), isokinetic muscle functions of the shoulder and knee joints, and biomechanical properties of core muscles.Methods Forty participants were randomly assigned to four groups: control group (CG, n = 10), compound set training group (CSG, n = 10), pyramid set training group (PSG, n = 10), and superset training group (SSG, n = 10). Excluding the CG, the other three groups underwent an 8-week resistance training program, three sessions per week, at 60%-80% of 1RM intensity for 60-90 min per session. Assessments included body composition, physical fitness components, 1RM, isokinetic muscle functions, and biomechanical properties (muscle frequency, stiffness, etc.) of the rectus abdominis and external oblique muscles.Results The PSG demonstrated the most significant improvement in relative peak torque during isokinetic testing of the shoulder and knee joints. Compared to the CG, all exercise groups exhibited positive effects on back strength, sprint performance, 1RM, and core muscle biomechanics. Notably, the PSG showed superior enhancement in external oblique stiffness. However, no significant differences were observed among the exercise groups for rectus abdominis biomechanical properties.Discussion Structured resistance training effectively improved maximal strength, functional performance, and core muscle biomechanics. The pyramidal training modality conferred specific benefits for isokinetic muscle functions and external oblique stiffness, suggesting its efficacy in enhancing force production capabilities and core stability. | Liu, Peng; Yuan, Han; Lu, Yunhang; Gao, Zeng | Jilin Sport Univ, Coll Martial Arts & Tradit Ethn Sports, Changchun, Peoples R China; Kyungpook Natl Univ, Dept Phys Educ, Daegu 41566, South Korea; Soochow Univ, Sch Phys Educ & Sports Sci, Suzhou, Peoples R China; Univ Sains Malaysia, Sch Educ Studies, Gelugor, Penang, Malaysia | PENG, LIU/KSM-7978-2024; Yuan, Han/LUY-3102-2024 | 59235263400; 58784951600; 57262012200; 59141458400 | 2021327546@knu.ac.kr; | FRONTIERS IN PHYSIOLOGY | FRONT PHYSIOL | 1664-042X | 15 | SCIE | PHYSIOLOGY | 2024 | 3.4 | 22.4 | 0.96 | 2025-05-07 | 2 | 3 | resistance training modalities; physical fitness; isokinetic muscle contraction; muscle biomechanics; pyramid set training | STRENGTH GAINS; HYPERTROPHY; PERFORMANCE; ADAPTATIONS; STRATEGIES; RESPONSES; AGONIST; DRIVE; FORCE; LOAD | isokinetic muscle contraction; muscle biomechanics; physical fitness; pyramid set training; resistance training modalities | caffeine; creatine; steroid; adduction; adult; Article; bioelectrical impedance analysis; biomechanics; body composition; body height; body mass; body weight; clinical article; controlled study; core muscle biomechanics; fat mass; fitness; heart rate; human; isokinetic muscle function; joint mobility; knee extension angle; knee function; leisure; male; muscle fatigue; muscle function; muscle rigidity; muscle strength; muscle tone; musculoskeletal disease; oblique external abdominal muscle; physical activity readiness questionnaire; polysomnography; questionnaire; randomized controlled trial; rectus abdominis muscle; resistance training; shoulder; squatting (exercise); stopwatch; stretching exercise; warm up; young adult | English | 2024 | 2024-07-12 | 10.3389/fphys.2024.1424216 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Resveratrol facilitates bone formation in high-glucose conditions | Periodontitis is known to be affected by high-glucose conditions, which poses a challenge to periodontal tissue regeneration, particularly in bone formation. In this study, the potential effects of resveratrol (3,5,4 '-trihydroxystilbene, RSV) in facilitating bone formation under high-glucose conditions after periodontitis has been investigated. We focused on the analysis of osteoblasts and periodontal ligament cells, which are essential for bone formation including cell proliferation and differentiation. And we aimed to investigate the impact of RSV on bone healing, employed diabetic mouse model induced by streptozotocin and confirmed through histological observation. High-glucose conditions adversely affected cell proliferation and ALP activity in both MC3T3-E1 and hPDLF in vitro, with more significant impact on MC3T3-E1 cells. RSV under high-glucose conditions had positive effects on both, showing early-stage effects for MC3T3-E1 cells and later-stage effects for hPDLF cells. RSV seemed to have a more pronounced rescuing role in MC3T3-E1 cells. Increased ALP activity was observed and the expression levels of significant genes, such as Col 1, TGF-beta 1, ALP, and OC, in osteogenic differentiation were exhibited stage-specific expression patterns. Upregulated Col 1 and TGF-beta 1 were detected in the early stage, and then ALP and OC expressions became more pronounced in the later stages. Similarly, stronger positive reactions against RUNX2 were detected in the RSV-treated group compared to the control. Furthermore, in in vivo experiment, RSV stimulates the growth and differentiation of osteoblasts, thereby promoting bone formation. High-glucose levels have the potential to impair cellular functions and the regenerative capacity to facilitate bone formation with MC3T3-E1 rather than hPDLF cells. Resveratrol appears to facilitate the inherent abilities of MC3T3-E1 cells compared with hPDLF cells, indicating its potential capacity to restore functionality during periodontal regeneration. | Hwang, Sung-Min; Kim, Tae-Young; Kim, Anna; Kim, Yong-Gun; Park, Jin-Woo; Lee, Jae-Mok; Kim, Jae-Young; Suh, Jo-Young | Kyungpook Natl Univ, Sch Dent, Dept Periodontol, IHBR, Daegu, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Biochem, IHBR, Daegu, South Korea | Kim, Yong-Gun/JPQ-3309-2023; Kim, Ji-Youn/A-5779-2017 | 57870525500; 57208461628; 58112989700; 55622694400; 58359647600; 17346330000; 56812734700; 7201514992 | jykim91@knu.ac.kr;jysuh@knu.ac.kr; | FRONTIERS IN PHYSIOLOGY | FRONT PHYSIOL | 1664-042X | 15 | SCIE | PHYSIOLOGY | 2024 | 3.4 | 22.4 | 1.61 | 2025-04-16 | 3 | 4 | periodontitis; diabetes mellitus; periodontium; osteoblast; osteogenesis; differentiation | PERIODONTAL-LIGAMENT CELLS; DIABETES-MELLITUS; OSTEOBLASTIC DIFFERENTIATION; OXIDATIVE STRESS; MC3T3-E1 CELLS; ALVEOLAR BONE; STEM-CELLS; PROLIFERATION; BACTERIA; RATS | diabetes mellitus; differentiation; osteoblast; osteogenesis; periodontitis; periodontium | alkaline phosphatase; glucose; osteocalcin; resveratrol; transcription factor RUNX2; transforming growth factor beta1; animal cell; animal experiment; animal model; animal tissue; Article; cell proliferation; controlled study; cytotoxicity; enzyme activity; enzyme linked immunosorbent assay; fracture healing; gene expression; histology; immunohistochemistry; in vitro study; male; MC3T3-E1 cell line; mouse; nonhuman; ossification; osteoblast; osteoclastogenesis; osteolysis; periodontitis; polymerase chain reaction; protein expression; real time polymerase chain reaction; streptozotocin-induced diabetes mellitus; tissue regeneration; upregulation | English | 2024 | 2024-04-19 | 10.3389/fphys.2024.1347756 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Roles of lncRNAs in NF-κB-Mediated Macrophage Inflammation and Their Implications in the Pathogenesis of Human Diseases | Over the past century, molecular biology's focus has transitioned from proteins to DNA, and now to RNA. Once considered merely a genetic information carrier, RNA is now recognized as both a vital element in early cellular life and a regulator in complex organisms. Long noncoding RNAs (lncRNAs), which are over 200 bases long but do not code for proteins, play roles in gene expression regulation and signal transduction by inducing epigenetic changes or interacting with various proteins and RNAs. These interactions exhibit a range of functions in various cell types, including macrophages. Notably, some macrophage lncRNAs influence the activation of NF-kappa B, a crucial transcription factor governing immune and inflammatory responses. Macrophage NF-kappa B is instrumental in the progression of various pathological conditions including sepsis, atherosclerosis, cancer, autoimmune disorders, and hypersensitivity. It orchestrates gene expression related to immune responses, inflammation, cell survival, and proliferation. Consequently, its malfunction is a key contributor to the onset and development of these diseases. This review aims to summarize the function of lncRNAs in regulating NF-kappa B activity in macrophage activation and inflammation, with a particular emphasis on their relevance to human diseases and their potential as therapeutic targets. The insights gained from studies on macrophage lncRNAs, as discussed in this review, could provide valuable knowledge for the development of treatments for various pathological conditions involving macrophages. | Shin, Jae-Joon; Park, Jeongkwang; Shin, Hyeung-Seob; Arab, Imene; Suk, Kyoungho; Lee, Won-Ha | Kyungpook Natl Univ, Sch Life Sci, BK21 Plus KNU Creat Biores Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Sch Med, Dept Pharmacol,BK21 Plus KNU Biomed Convergence Pr, Daegu 41944, South Korea | 58662949200; 58663723600; 58663723700; 58663912800; 7005114595; 57205609794 | wowns1124@knu.ac.kr;wjdrhkd28787@gmail.com;gudals3963@naver.com;arabimene07@gmail.com;ksuk@knu.ac.kr;whl@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 5 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 2.57 | 2025-05-07 | 20 | 20 | human diseases; inflammation; lncRNA; macrophage; NF-kappa B | TUMOR-ASSOCIATED MACROPHAGES; CELL-PROLIFERATION; PROMOTES PROLIFERATION; ENDOTHELIAL-CELLS; RAW264.7 CELLS; RNA; MALAT1; ATHEROSCLEROSIS; POLARIZATION; CANCER | human diseases; inflammation; lncRNA; macrophage; NF-κB | Humans; Inflammation; Macrophages; NF-kappa B; RNA, Long Noncoding; Signal Transduction; immunoglobulin enhancer binding protein; long untranslated RNA; immunoglobulin enhancer binding protein; long untranslated RNA; atherosclerosis; autoimmune disease; autoimmunity; cell proliferation; cell survival; gene expression regulation; human; hypersensitivity; immune response; immunomodulation; inflammation; macrophage; macrophage activation; malignant neoplasm; nonhuman; pathogenesis; Review; sepsis; signal transduction; genetics; inflammation; macrophage; metabolism | English | 2024 | 2024-03 | 10.3390/ijms25052670 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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