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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Association between psychological vulnerability and glaucoma progression: Protocol for a multicenter prospective cohort study in South Korea | IntroductionMental health is a significant concern for patients diagnosed with glaucoma, as visual impairment can have a profound impact on psychological well-being. Conversely, psychological vulnerability in glaucoma patients can negatively influence treatment adherence to ocular hypotensive therapy, thereby potentially exacerbating disease progression in a vicious cycle. The study protocol proposed herein aims to explore the impact of psychological states such as anxiety, depression, and stress on both medication adherence and progression of glaucoma.Materials and methodsThis study is to be a prospective multicenter study conducted at four tertiary medical centers. Patients recently diagnosed with glaucoma and not yet treated will be enrolled. Anxiety, depression, and stress scales will be administered at baseline, one year, and two years, along with glaucomatous assessments to be performed every six months. Validated questionnaires (Generalized Anxiety Disorder Assessment [GAD-7], Patient Health Questionnaire [PHQ-9], and Perceived Stress Scale-10 [PSS-10]) will assess anxiety, depression, and stress, respectively. The primary objective is to correlate post-diagnosis psychological status with medication adherence and disease progression. The effects of pre- and post-diagnosis changes in anxiety, depression, and stress on disease progression will be analyzed. Kaplan-Meier survival analysis and logistic regression will be performed to identify clinical characteristics associated with increased risk of developing anxiety, depression, and stress in glaucoma patients. | Baek, Sung Uk; Kim, Jin-Soo; Kim, Dai Woo; Ha, Ahnul; Kim, Young Kook | Hallym Univ, Coll Med, Dept Ophthalmol, Anyang, South Korea; Hallym Univ, Dept Ophthalmol, Sacred Heart Hosp, Anyang, South Korea; Chungnam Natl Univ, Dept Ophthalmol, Sejong Hosp, Sejong, South Korea; Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, Daegu, South Korea; Jeju Natl Univ Hosp, Dept Ophthalmol, Jeju Si, South Korea; Jeju Natl Univ, Sch Med, Dept Ophthalmol, Jeju Si, South Korea; Seoul Natl Univ Hosp, Dept Ophthalmol, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea; EyeLight Data Sci Lab, Seoul, South Korea | Kim, Young-Kook/AAE-8306-2020; Ha, Ahnul/ABD-1589-2020 | 57202379043; 57207871624; 57095192800; 57189002120; 55908959500 | md092@naver.com; | PLOS ONE | PLOS ONE | 1932-6203 | 18 | 10 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 2.9 | 23.5 | 0.12 | 2025-06-25 | 1 | 1 | QUALITY-OF-LIFE; GENERALIZED ANXIETY DISORDER; VISUAL-FIELD PROGRESSION; INTRAOCULAR-PRESSURE; MEDICATION ADHERENCE; DEPRESSIVE SYMPTOMS; VALIDITY; PHQ-9; GAD-7 | Anxiety; Anxiety Disorders; Depression; Disease Progression; Glaucoma; Humans; Multicenter Studies as Topic; Prospective Studies; adult; anxiety; Article; best corrected visual acuity; cohort analysis; depression; Depression, Anxiety and Stress Scale; disease exacerbation; emotional disorder; eye examination; eye fundus; eye surgery; female; Generalized Anxiety Disorder-7; glaucoma; gonioscopy; human; intraocular pressure; major clinical study; male; medication compliance; multicenter study; neuropathy; open angle glaucoma; optic disk; optical coherence tomography; pachymetry; Patient Health Questionnaire 9; Perceived Stress Scale; photography; psychological vulnerability; questionnaire; retinal nerve fiber layer; stereoscopic vision; visual acuity; visual field; vulnerability; anxiety disorder; disease exacerbation; multicenter study (topic); prospective study; psychology | English | 2023 | 2023-10-10 | 10.1371/journal.pone.0292599 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Automated 3-dimensional MRI segmentation for the posterosuperior rotator cuff tear lesion using deep learning algorithm | IntroductionRotator cuff tear (RCT) is a challenging and common musculoskeletal disease. Magnetic resonance imaging (MRI) is a commonly used diagnostic modality for RCT, but the interpretation of the results is tedious and has some reliability issues. In this study, we aimed to evaluate the accuracy and efficacy of the 3-dimensional (3D) MRI segmentation for RCT using a deep learning algorithm. MethodsA 3D U-Net convolutional neural network (CNN) was developed to detect, segment, and visualize RCT lesions in 3D, using MRI data from 303 patients with RCTs. The RCT lesions were labeled by two shoulder specialists in the entire MR image using in-house developed software. The MRI-based 3D U-Net CNN was trained after the augmentation of a training dataset and tested using randomly selected test data (training: validation: test data ratio was 6:2:2). The segmented RCT lesion was visualized in a three-dimensional reconstructed image, and the performance of the 3D U-Net CNN was evaluated using the Dice coefficient, sensitivity, specificity, precision, F1-score, and Youden index. ResultsA deep learning algorithm using a 3D U-Net CNN successfully detected, segmented, and visualized the area of RCT in 3D. The model's performance reached a 94.3% of Dice coefficient score, 97.1% of sensitivity, 95.0% of specificity, 84.9% of precision, 90.5% of F1-score, and Youden index of 91.8%. ConclusionThe proposed model for 3D segmentation of RCT lesions using MRI data showed overall high accuracy and successful 3D visualization. Further studies are necessary to determine the feasibility of its clinical application and whether its use could improve care and outcomes. | Lee, Su Hyun; Lee, JiHwan; Oh, Kyung-Soo; Yoon, Jong Pil; Seo, Anna; Jeong, YoungJin; Chung, Seok Won | Seoul Red Cross Hosp, Dept Orthopaed Surg, Seoul, South Korea; Myongji Hosp, Dept Orthoped Surg, Goyang Si, South Korea; Konkuk Univ, Dept Orthopaed Surg, Sch Med, Seoul, South Korea; Kyungpook Natl Univ, Dept Orthopaed Surg, Coll Med, Daegu, South Korea; SEEANN Solut, Incheon, South Korea | Lee, Su/ISU-5629-2023 | 57217106424; 57202007254; 57693386500; 36098548400; 57203982323; 58265150400; 37065938600 | smilecsw@gmail.com; | PLOS ONE | PLOS ONE | 1932-6203 | 18 | 5 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 2.9 | 23.5 | 1.53 | 2025-06-25 | 14 | 13 | MAGNETIC-RESONANCE IMAGES; CLASSIFICATION; ACCURACY; SHOULDER; NET | Algorithms; Deep Learning; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Rotator Cuff Injuries; adult; aged; Article; convolutional neural network; deep learning; diagnostic accuracy; diagnostic test accuracy study; diagnostic value; digital imaging and communications in medicine; female; human; image analysis; image processing; image reconstruction; image segmentation; major clinical study; male; medical specialist; nuclear magnetic resonance imaging; retrospective study; rotator cuff rupture; sensitivity and specificity; three-dimensional imaging; very elderly; Youden index; algorithm; diagnostic imaging; nuclear magnetic resonance imaging; procedures; rotator cuff injury; three-dimensional imaging | English | 2023 | 2023-05-18 | 10.1371/journal.pone.0284111 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Cervical kinematic change after posterior full-endoscopic cervical foraminotomy for disc herniation or foraminal stenosis | ObjectivePosterior full-endoscopic cervical foraminotomy (PECF) is one of minimally invasive surgical techniques for cervical radiculopathy. Because of minimal disruption of posterior cervical structures, such as facet joint, cervical kinematics was minimally changed. However, a larger resection of facet joint is required for cervical foraminal stenosis (FS) than disc herniation (DH). The objective was to compare the cervical kinematics between patients with FS and DH after PECF. MethodsConsecutive 52 patients (DH, 34 vs. FS, 18) who underwent PECF for single-level radiculopathy were retrospectively reviewed. Clinical parameters (neck disability index, neck pain and arm pain), and segmental, cervical and global radiological parameters were compared at postoperative 3, 6, and 12 months, and yearly thereafter. A linear mixed-effect model was used to assess interactions between groups and time. Any occurrence of significant pain during follow-up was recorded during a mean follow-up period of 45.5 months (range 24-113 months). ResultsClinical parameters improved after PECF, with no significant differences between groups. Recurrent pain occurred in 6 patients and surgery (PECF, anterior discectomy and fusion) was performed in 2 patients. Pain-free survival rate was 91% for DH and 83% for FS, with no significant difference between the groups (P = 0.29). Radiological changes were not different between groups (P > 0.05). Segmental neutral and extension curvature became more lordotic. Cervical curvature became more lordotic on neutral and extension X-rays, and the range of cervical motion increased. The mismatch between T1-slope and cervical curvature decreased. Disc height did not change, but the index level showed degeneration at postoperative 2 years. ConclusionClinical and radiological outcomes after PECF were not different between DH and FS patients and kinematics were significantly improved. These findings may be informative in a shared decision-making process. | Paik, Seungyoon; Choi, Yunhee; Chung, Chun Kee; Won, Young Il; Park, Sung Bae; Yang, Seung Heon; Lee, Chang-Hyun; Rhee, John Min; Kim, Kyoung-Tae; Kim, Chi Heon | Seoul Natl Univ, Dept Med, Coll Med, Seoul, South Korea; Seoul Natl Univ Hosp, Med Res Collaborating Ctr, Div Med Stat, Seoul, South Korea; Seoul Natl Univ, Dept Neurosurg, Coll Med, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Neurosurg, Seoul, South Korea; Seoul Natl Univ, Dept Brain & Cognit Sci, Seoul, South Korea; Chungnam Natl Univ Sejong Hosp, Dept Neurosurg, Sejong, South Korea; Seoul Natl Univ, Dept Neurosurg, Boramae Hosp, Seoul, South Korea; Seoul Natl Univ, Dept Neurosurg, Bundang Hosp, Seongnam Si, Gyeonggi Do, South Korea; Emory Univ, Dept Orthopaed Surg, Sch Med, Atlanta, GA USA; Kyungpook Natl Univ Hosp, Dept Neurosurg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu, South Korea; Seoul Natl Univ, Dept Med Device Dev, Coll Med, Seoul, South Korea | ; Choi, You-Jung/AFR-4193-2022; Lee, Chang-Hoon/AAC-7650-2021; Kim, Chi/J-6536-2019 | 57216891297; 7404777879; 7403613043; 57744628900; 45261436700; 56440402100; 56942572100; 7202839338; 57201369790; 35145892000 | chiheon1@snu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 18 | 2 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 2.9 | 23.5 | 0.24 | 2025-06-25 | 1 | 2 | SAGITTAL ALIGNMENT; DISKECTOMY; ANTERIOR; FUSION; RADICULOPATHY; SURGERY; COMPLICATIONS; DISEASE | Biomechanical Phenomena; Cervical Vertebrae; Constriction, Pathologic; Diskectomy; Foraminotomy; Humans; Intervertebral Disc Displacement; Radiculopathy; Retrospective Studies; Treatment Outcome; adult; anterior cervical discectomy and fusion; anthropometric parameters; Article; body mass; case report; cervical disk hernia; cervical spinal stenosis; clinical article; clinical evaluation; clinical outcome; computer assisted tomography; diabetes mellitus; endoscopy; facetectomy; female; follow up; foraminotomy; human; kinematics; laminectomy; major clinical study; male; Neck Disability Index; neck pain; nuclear magnetic resonance imaging; numeric rating scale; occupation; outcome assessment; people by smoking status; questionnaire; radiculopathy; radiological parameters; range of motion; retrospective study; shared decision making; survival rate; T1 slope; X ray; biomechanics; cervical vertebra; discectomy; intervertebral disk hernia; procedures; radiculopathy; stenosis, occlusion and obstruction; treatment outcome | English | 2023 | 2023-02-21 | 10.1371/journal.pone.0281926 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Coagulation measures after cardiac arrest (CMACA) | Background During cardiac arrest (CA) and after cardiopulmonary resuscitation, activation of blood coagulation and inadequate endogenous fibrinolysis occur. The aim of this study was to describe the time course of coagulation abnormalities after out-of-hospital CA (OHCA) and to examine the association with clinical outcomes in patients undergoing targeted temperature management (TTM) after OHCA. Methods This prospective, multicenter, observational cohort study was performed in eight emergency departments in Korea between September 2018 and September 2019. Laboratory findings from hospital admission and 24 hours after return of spontaneous circulation (ROSC) were analyzed. The primary outcome was cerebral performance category (CPC) at discharge, and the secondary outcome was in-hospital mortality. Results A total of 170 patients were included in this study. The lactic acid, prothrombin time (PT), activated partial thrombin time (aPTT), international normalized ratio (INR), and D-dimer levels were higher in patients with poor neurological outcomes at admission and 24 h after ROSC. The lactic acid and D-dimer levels decreased over time, while fibrinogen increased over time. PT, aPTT, and INR did not change over time. The PT at admission and D-dimer levels 24 h after ROSC were associated with neurological outcomes at hospital discharge. Coagulation-related factors were moderately correlated with the duration of time from collapse to ROSC. Conclusion The time-dependent changes in coagulation-related factors are diverse. Among coagulation-related factors, PT at admission and D-dimer levels 24 h after ROSC were associated with poor neurological outcomes at hospital discharge in patients treated with TTM. | Kim, Hyo Joon; Michael, Kurz; Wee, Jung Hee; Oh, Joo Suk; Kim, Won Young; Cho, In Soo; Lee, Mi Jin; Lee, Dong Hun; Kim, Yong Hwan; Youn, Chun Song | Catholic Univ Korea, Seoul St Mary Hosp, Coll Med, Dept Emergency Med, Seoul, South Korea; Univ Alabama Birmingham, Sch Med, Dept Emergency Med, Birmingham, AL USA; Catholic Univ Korea, Coll Med, Yeouido St Marys Hosp, Dept Emergency Med, Seoul, South Korea; Catholic Univ Korea, Coll Med, Uijeongbu St Marys Hosp, Dept Emergency Med, Uijongbu, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Emergency Med, Seoul, South Korea; Hanil Gen Hosp, Dept Emergency Med, Korea Elect Power Med Corp, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Emergency Med, Daegu, South Korea; Chonnam Natl Univ, Med Sch, Dept Emergency Med, Gwangju, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Changwon Hosp, Dept Emergency Med, Chang Won, South Korea | Lee, Sang-hun/JWA-2671-2024; Kim, Su Hyun/JPY-2079-2023 | 57191722635; 58046393400; 55077812400; 35215910200; 55661654200; 56179020400; 55507282600; 57203284924; 57203585723; 35747536800 | ycs1005@catholic.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 18 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 2.9 | 23.5 | 1.06 | 2025-06-25 | 7 | 9 | SUCCESSFUL CARDIOPULMONARY-RESUSCITATION; INTERNATIONAL LIAISON COMMITTEE; D-DIMER; COAGULOPATHY; MORTALITY; OUTCOMES; CARE | Blood Coagulation; Cardiopulmonary Resuscitation; Humans; Lactic Acid; Out-of-Hospital Cardiac Arrest; Prospective Studies; Treatment Outcome; D dimer; fibrinogen; lactic acid; lactic acid; activated partial thrombin time; adult; Article; blood clotting; blood clotting parameters; clinical feature; cohort analysis; female; heart arrest; hospital admission; hospital discharge; hospital mortality; human; international normalized ratio; Korea; lactate blood level; major clinical study; male; middle aged; observational study; prognosis; prospective study; prothrombin time; return of spontaneous circulation; risk factor; blood clotting; clinical trial; multicenter study; out of hospital cardiac arrest; resuscitation; treatment outcome | English | 2023 | 2023-01-06 | 10.1371/journal.pone.0279653 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Comparison of incidence and outcome between occupational and non-occupational motorcycle injuries in Korea: A 7-years observational study | Motorcycles are widely used in various workplaces. Motorcycle use for occupational purposes continues to increase owing to growing e-commerce. Here, we aimed to highlight the importance of occupational motorcycle injuries by analyzing their epidemiologic characteristics and outcomes. We analyzed retrospective data from the Emergency Department-based Injury In-depth Surveillance program from 2012 to 2018. Motor vehicle injuries involving riders aged >= 16 years were included. Patients were divided into occupational motorcycle and non-occupational motorcycle injury groups based on whether or not the injury occurred during work time. General characteristics, injury details, and clinical outcomes such as injury severity and in-hospital mortality were analyzed. Of the 37,194 study patients, 24.2% (8,991) experienced occupational motorcycle injuries. The number of injuries in both groups increased yearly, as did the proportion of occupational injuries among total injuries. In both the groups, patients aged 20-29 years had the highest proportion of injuries. Regarding collision pattern and injury counterpart, side-to-side collisions and injuries involving small four-wheel vehicles were the most frequent. Alcohol intake was significantly lower, while helmet usage was higher in the occupational motorcycle injury group. Moreover, patients with occupational motorcycle injuries had lower injury severity, admission rate, and in-hospital mortality. On multivariable logistic regression analysis, increasing age, time of the injury, alcohol intake, not using a helmet, and collision with a human or animal were associated with higher odds of severe injury. Patients with occupational injuries had higher helmet usage, lower injury severity, lower mortality, and lower admission rate than did patients with non-occupational injuries. Injury severity was associated with the time of injury, collision with other living objects, alcohol consumption, and helmet usage. | Moon, Sungbae; Ryoo, Hyun Wook; Cho, Jae Wan; Jung, Haewon; Seo, Kang Suk; Lim, Kyoung Hoon | Kyungpook Natl Univ, Sch Med, Dept Emergency Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea | ; Moon, Sungbae/F-4010-2015 | 57191584601; 55350557500; 7403536065; 57221554827; 57204305189; 25630643100 | ryoo@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 18 | 3 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 2.9 | 23.5 | 0.35 | 2025-06-25 | 4 | 3 | CRASHES; VIOLATIONS; ACCIDENTS; SEVERITY; DRIVERS; SAFETY | Accidents, Traffic; Humans; Incidence; Motorcycles; Occupational Injuries; Republic of Korea; Retrospective Studies; adult; aged; alcohol consumption; Article; clinical outcome; cross-sectional study; electronic commerce; emergency health service; emergency ward; face injury; female; health insurance; helmet; hospital admission; human; in-hospital mortality; incidence; information service; injury severity; intensive care; Korea; long term care; male; medical practice; motorcycle; observational study; occupational accident; paramedical personnel; patient transport; retrospective study; telephone interview; traffic; traffic accident; occupational accident; South Korea; traffic accident | English | 2023 | 2023-03-29 | 10.1371/journal.pone.0283512 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Drug-Drug interactions of docetaxel in patients with breast cancer based on insurance claims data | Despite an increase in the use of targeted anticancer drugs and immunotherapy, cytotoxic anticancer drugs such as docetaxel continue to play a clinically important role. The aim of this study was to evaluate drug-drug interactions between docetaxel and coadministered medicines in patients with breast cancer a claims database. The Health Insurance Review and Assessment Service (HIRA) database (2017 to 2019) was used in this study. We evaluated the risk of neutropenia (defined using receipt of granulocyte colony-stimulating factor (G-CSF) prescriptions) under docetaxel administration or the coadministration of docetaxel and an interacting anticancer drug (predefined based on approval information obtained from the Korean Ministry of Food and Drug Safety and the Lexicomp electronic database). The propensity score matching method was applied to balance covariates in the case (patients with G-CSF prescriptions) and control (patients without G-CSF prescriptions) groups. We identified 947 female patients with breast cancer prescribed with docetaxel and excluded 321 patients based on inclusion criteria. Of the remaining 626 patients, 280 were assigned to the case group and 346 to the control group. Predefined drugs were coadministered to 71 (11.3%) patients during the 7-day period before and after the administration of docetaxel. Adjusted odds ratios (ORs) calculated using the logistic regression model applied to the propensity score matching showed no significant difference between the administration of docetaxel alone and docetaxel coadministration (adjusted OR, 2.010; 95% confidence interval, 0.906, 4.459). In conclusion, we suggest that coadministration of docetaxel and a predefined interacting drug are not associated with G-CSF prescription. | Shin, Kwang-Hee; Ah, Young-Mi; Cha, Sang Hun; Choi, Hye Duck | Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu, South Korea; Yeungnam Univ, Coll Pharm, Gyongsan, Gyeongbuk, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Dept Stat, Daegu, South Korea | ; ah, y/KIK-2108-2024 | 35216279300; 25623061000; 57638252600; 36877353300 | chd80@hotmail.com; | PLOS ONE | PLOS ONE | 1932-6203 | 18 | 6 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 2.9 | 23.5 | 0 | 2025-06-25 | 0 | 0 | Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Docetaxel; Drug Interactions; Female; Granulocyte Colony-Stimulating Factor; Humans; Insurance; Neutropenia; Taxoids; carboplatin; cisplatin; clarithromycin; docetaxel; antineoplastic agent; docetaxel; granulocyte colony stimulating factor; taxoid; adult; Article; breast cancer; case control study; clinical feature; controlled study; drug screening; female; health hazard; health insurance; human; major clinical study; middle aged; outcome assessment; prescription; breast tumor; drug interaction; insurance; neutropenia | English | 2023 | 2023-06-16 | 10.1371/journal.pone.0287382 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Effects of announcing a vocabulary test before reading a glossed text on reading behaviors and vocabulary acquisition: An eye-tracking study | Glosses provide an effective way of fostering second language (L2) vocabulary acquisition. Expanding on previous research, we explored how a vocabulary test announcement prior to reading a glossed text influences the reading behaviors and subsequent vocabulary acquisition of L2 learners. The participants of this study comprised 65 Korean undergraduate students. The participants were assigned to either a vocabulary test announcement (TA) or a no test announcement (NTA) group. Thereafter, the researchers read to the participants a short story containing 16 glossed words displayed in the bottom margin. The students' responses to the reading comprehension test and a battery of vocabulary tests (i.e., form recall, meaning recall, and meaning recognition) were captured immediately and one week after the assessments. The results showed that while processing in-text target words and marginal glosses, no variation in eye-tracking measures (e.g., gaze duration and total reading time) was observed among the TA and NTA groups. In contrast, the TA group spent significantly longer time fixating on bottom-margin target words than the NTA group during eye-tracking measures. Regardless of the testing phase, the vocabulary test results showed that only the form recall scores in the TA group were significantly higher than the NTA group. However, the differences in meaning recall and recognition scores were not significant. Collectively, these results suggest that vocabulary test announcements likely enhance the favorable effects of glossed text, particularly through promoting visual word form acquisition. However, the effects do not strengthen form-meaning associations without compromising L2 learners' reading comprehension. | Kim, Hayoung; Choi, Sungmook; Kweon, Soo-Ok | Kyungpook Natl Univ, Teachers Coll, Dept English Educ, Daegu, South Korea; Pohang Univ Sci & Technol, Div Humanities & Social Sci, Pohang, South Korea | 58073743800; 56124260900; 37067465400 | soook@postech.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 18 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 2.9 | 23.5 | 0.12 | 2025-06-25 | 0 | 1 | DICTIONARY USE; L2 | Comprehension; Eye-Tracking Technology; Humans; Language; Language Tests; Mental Recall; Vocabulary; adult; article; eye tracking; female; gaze; human; human experiment; major clinical study; male; reading; recall; undergraduate student; vocabulary; comprehension; language; language test; physiology | English | 2023 | 2023-01-19 | 10.1371/journal.pone.0280552 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Exploration of street space architectural color measurement based on street view big data and deep learning-A case study of Jiefang North Road Street in Tianjin | Urban space architectural color is the first feature to be perceived in a complex vision beyond shape, texture and material, and plays an important role in the expression of urban territory, humanity and style. However, because of the difficulty of color measurement, the study of architectural color in street space has been difficult to achieve large-scale and fine development. The measurement of architectural color in urban space has received attention from many disciplines. With the development and promotion of information technology, the maturity of street view big data and deep learning technology has provided ideas for the research of street architectural color measurement. Based on this background, this study explores a highly efficient and large-scale method for determining architectural colors in urban space based on deep learning technology and street view big data, with street space architectural colors as the research object. We conducted empirical research in Jiefang North Road, Tianjin. We introduced the SegNet deep learning algorithm to semantically segment the street view images, extract the architectural elements and optimize the edges of the architecture. Based on K-Means clustering model, we identified the colors of the architectural elements in the street view. The accuracy of the building color measurement results was cross-sectionally verified by means of a questionnaire survey. The validation results show that the method is feasible for the study of architectural colors in street space. Finally, the overall coordination, sequence continuity, and primary and secondary hierarchy of architectural colors of Jiefang North Road in Tianjin were analyzed. The results show that the measurement model can realize the intuitive expression of architectural color information, and also can assist designers in the analysis of architectural color in street space with the guidance of color characteristics. The method helps managers, planners and even the general public to summarize the characteristics of color and dig out problems, and is of great significance in the assessment and transformation of the color quality of the street space environment. | Han, Xin; Yu, Ying; Liu, Lei; Li, Ming; Wang, Lei; Zhang, Tianlin; Tang, Fengliang; Shen, Yingning; Li, Mingshuai; Yu, Shibao; Peng, Hongxu; Zhang, Jiazhen; Wang, Fangzhou; Ji, Xiaomeng; Zhang, Xinpeng; Hou, Min | Kyungpook Natl Univ, Dept Landscape Architecture, Daegu, South Korea; Shandong Agr Univ, Coll Forestry, Dept Landscape Architecture, Tai An, Shandong, Peoples R China; Harbin Inst Technol, Sch Architecture, Shenzhen, Peoples R China; Gengdan Inst Beijing Univ Technol, Gengdan Acad Design, Beijing, Peoples R China; Tianjin Univ, Sch Architecture, Tianjin, Peoples R China; Northwest Univ, Sch Cultural Heritage, Xian, Peoples R China; Lanzhou Jiaotong Univ, Sch Architecture & Urban Planning, Lanzhou, Peoples R China; Fuzhou Univ, Sch Architecture & Urban Rural Planning, Fuzhou, Peoples R China; Inst Planning Design Co Ltd, Chengdu Tianfu New Area, Chengdu, Peoples R China; Ocean Univ China, Dept Tourism, Management Coll, Qingdao, Peoples R China; Shandong Jianzhu Univ, Landscape Architecture Res Ctr, Jinan, Peoples R China; Fuzhou Planning & Design Res Inst Grp Co Ltd, Fuzhou, Peoples R China | 磊, 王/KFS-1412-2024 | 57716224500; 58742619600; 57794935300; 58742768800; 57715975800; 57566573700; 58742769000; 58742619700; 58742010700; 58742619800; 58742769100; 58741858400; 58742466800; 58742916200; 57199152378; 58742162900 | wanglei2021@tju.edu.cn;zhangtianlineric@tju.edu.cn;tang_fengliang@tju.edu.cn;202210097@stumail.nwu.edu.cn;limingshuai.lee@gmail.com;yushibao@tju.edu.cn;penghongxu@fzu.edu.cn;zhangjz_2015@tju.edu.cn;tangfengliang@tju.edu.cn;zhangjz2015@tju.edu.cn; | PLOS ONE | PLOS ONE | 1932-6203 | 18 | 11 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 2.9 | 23.5 | 0.59 | 2025-06-25 | 4 | 5 | PERCEPTIONS | Big Data; Cluster Analysis; Deep Learning; Surveys and Questionnaires; adult; article; big data; case study; color; deep learning; digital technology; empirical research; human; information technology; k means clustering; learning algorithm; maturity; open access publishing; questionnaire; space; cluster analysis | English | 2023 | 2023-11-30 | 10.1371/journal.pone.0289305 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Impact of emergency medical service with advanced life support training for adults with out-of-hospital cardiac arrest in the Republic of Korea: A retrospective multicenter study | Prehospital advanced life support (ALS) has been offered in many countries for patients experiencing out-of-hospital cardiac arrest (OHCA); however, its effectiveness remains unclear. This study aimed to determine the impact of emergency medical service (EMS) with ALS training as a nationwide pilot project for adults with OHCA in the Republic of Korea. This retrospective multicenter observational study was conducted between July 2019 and December 2020 using the Korean Cardiac Arrest Research Consortium registry. The patients were categorized into an intervention group that received EMS with ALS training and a control group that did not receive EMS with ALS training. Conditional logistic regression analysis was performed using matched data to compare clinical outcomes between the two groups. Compared with the control group, the intervention group had a lower rate of supraglottic airway usage (60.5% vs. 75.6%) and a higher rate of undergoing endotracheal intubation (21.7% vs. 6.1%, P < 0.001). In addition, the intervention group was administered more intravenous epinephrine (59.8% vs. 14.2%, P < 0.001) and used mechanical chest compression devices more frequently in prehospital settings than the control group (59.0% vs. 23.8%, P < 0.001). Based on the results of multivariable conditional logistic regression analysis, survival to hospital discharge (odds ratio: 0.48, 95% confidence interval: 0.27-0.87) of the intervention group was significantly lower than that of the control group; however, good neurological outcome was not significantly different between the two groups. In this study, survival to hospital discharge was worse in patients with OHCA who received EMS with ALS training than in those who did not. | Ahn, Jae Yun; Ryoo, Hyun Wook; Jung, Haewon; Ro, Young Sun; Park, Jeong Ho | Kyungpook Natl Univ, Sch Med, Dept Emergency Med, Daegu, South Korea; Seoul Natl Univ Hosp Biomed Res Inst, Lab Emergency Med Serv, Seoul, South Korea; Seoul Natl Univ Coll Med & Hosp, Dept Emergency Med, Seoul, South Korea | Ahn, Jae Yun/N-2652-2017 | 56937505400; 55350557500; 57221554827; 37665990400; 57222635486 | ryoo@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 18 | 6 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 2.9 | 23.5 | 0.35 | 2025-06-25 | 3 | 4 | CARDIOPULMONARY-RESUSCITATION; VENTRICULAR-FIBRILLATION; ENDOTRACHEAL INTUBATION; TRACHEAL INTUBATION; OUTCOMES; SURVIVAL; STRATEGY | Adult; Amyotrophic Lateral Sclerosis; Cardiopulmonary Resuscitation; Emergency Medical Services; Humans; Out-of-Hospital Cardiac Arrest; Pilot Projects; Registries; Republic of Korea; Retrospective Studies; epinephrine; adult; advanced life support; aged; Article; cerebral performance category scale; clinical outcome; controlled study; emergency health service; endotracheal intubation; female; human; logistic regression analysis; major clinical study; male; multicenter study; observational study; out of hospital cardiac arrest; register; retrospective study; South Korea; survival to hospital discharge; amyotrophic lateral sclerosis; clinical trial; out of hospital cardiac arrest; pilot study; procedures; resuscitation | English | 2023 | 2023-06-08 | 10.1371/journal.pone.0286047 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Molecular dynamics of the ERRγ ligand-binding domain bound with agonist and inverse agonist | Estrogen-related receptor gamma (ERR gamma), the latest member of the ERR family, does not have any known reported natural ligands. Although the crystal structures of the apo, agonist-bound, and inverse agonist-bound ligand-binding domain (LBD) of ERR gamma have been solved previously, their dynamic behavior has not been studied. Hence, to explore the intrinsic dynamics of the apo and ligand-bound forms of ERR gamma, we applied long-range molecular dynamics (MD) simulations to the crystal structures of the apo and ligand-bound forms of the LBD of ERR gamma. Using the MD trajectories, we performed hydrogen bond and binding free energy analysis, which suggested that the agonist displayed more hydrogen bonds with ERR gamma than the inverse agonist 4-OHT. However, the binding energy of 4-OHT was higher than that of the agonist GSK4716, indicating that hydrophobic interactions are crucial for the binding of the inverse agonist. From principal component analysis, we observed that the AF-2 helix conformation at the C-terminal domain was similar to the initial structures during simulations, indicating that the AF-2 helix conformation is crucial with respect to the agonist or inverse agonist for further functional activity of ERR gamma. In addition, we performed residue network analysis to understand intramolecular signal transduction within the protein. The betweenness centrality suggested that few of the amino acids are important for residue signal transduction in apo and ligand-bound forms. The results from this study may assist in designing better therapeutic compounds against ERR gamma associated diseases. | Sasidharan, Santanu; Radhakrishnan, Kamalakannan; Lee, Jun-Yeong; Saudagar, Prakash; Gosu, Vijayakumar; Shin, Donghyun | Natl Inst Technol, Dept Biotechnol, Warangal, Telangana, India; Chonnam Natl Univ Med Sch, Combinatorial Tumor Immunotherapy MRC, Hwasun Gun, Jeonnam, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat Biores Grp, Daegu, South Korea; Jeonbuk Natl Univ, Dept Anim Biotechnol, Jeonju, South Korea; Jeonbuk Natl Univ, Dept Agr Convergence Technol, Jeonju, South Korea | Sasidharan, Santanu/M-3429-2016; Radhakrishnan, Kamalakannan/HNP-0477-2023; Saudagar, Prakash/ABE-7270-2020 | 57204197009; 57217673988; 56428518900; 54411376700; 55484639100; 56591172300 | gosu@jbnu.ac.kr;sdh1214@gmail.com; | PLOS ONE | PLOS ONE | 1932-6203 | 18 | 4 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 2.9 | 23.5 | 1.18 | 2025-06-25 | 11 | 10 | INDEPENDENT TRANSCRIPTIONAL ACTIVATION; ORPHAN NUCLEAR RECEPTORS; ESTROGEN; GENE; SHP; IDENTIFICATION; METABOLISM; EXPRESSION; PROMOTER; GROMACS | Drug Inverse Agonism; Furylfuramide; Ligands; Molecular Dynamics Simulation; Receptors, Estrogen; 4 oht; 9 hydroxytamoxifen; estrogen receptor; estrogen related receptor gamma; gsk 4716; hormone receptor stimulating agent; hydroxytamoxifen; unclassified drug; estrogen receptor; furylfuramide; ligand; Article; binding affinity; carboxy terminal sequence; conformational transition; controlled study; drug receptor binding; hydrogen bond; hydrophobicity; molecular dynamics; principal component analysis; protein function; signal transduction; thermostability; inverse agonism; metabolism | English | 2023 | 2023-04-06 | 10.1371/journal.pone.0283364 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | MOPA: An integrative multi-omics pathway analysis method for measuring omics activity | Pathways are composed of proteins forming a network to represent specific biological mechanisms and are often used to measure enrichment scores based on a list of genes in means to measure their biological activity. The pathway analysis is a de facto standard downstream analysis procedure in most genomic and transcriptomic studies. Here, we present MOPA (Multi-Omics Pathway Analysis), which is a multi-omics integrative method that scores individual pathways in a sample wise manner in terms of enriched multi-omics regulatory activity, which we refer to mES (multi-omics Enrichment Score). The mES score reflects the strength of regulatory relations between multi-omics in units of pathways. In addition, MOPA is able to measure how much each omics contribute to mES that may be used to observe what kind of omics are active in a pathway within a sample group (e.g., subtype, gender), which we refer to OCR (Omics Contribution Rate). Using nine different cancer types, 93 clinical features and three types of omics (i.e., gene expression, miRNA and methylation), MOPA was used to search for clinical features that were explainable in context of multi-omics. By evaluating the performance of MOPA, we showed that it yielded higher or at least equal performance compared to previous single and multi-omics pathway analysis tools. We find that the advantage of MOPA is the ability to explain pathways in terms of omics relation using mES and OCR. As one of the results, the TGF-beta signaling pathway was captured as an important pathway that showed distinct mES and OCR values specific to the CMS4 subtype in colon adenocarcinoma. The mES and OCR metrics suggested that the mRNA and miRNA expressions were significantly different from the other subtypes, which was concordant with previous studies. The MOPA software is available at https://github.com/jaeminjj/MOPA. | Jeon, Jaemin; Han, Eon Yong; Jung, Inuk | Kyungpook Natl Univ, Sch Comp Sci & Engn, Deagu, South Korea; Seoul Natl Univ, Interdisciplinary Program Bioinformat, Seoul, South Korea | Jung, Inuk/T-1981-2018 | 58145888700; 58144883400; 56067575500 | inukjung@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 18 | 3 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 2.9 | 23.5 | 0.35 | 2025-06-25 | 2 | 3 | CONSENSUS MOLECULAR SUBTYPES; GASTRIC-CANCER; EXPRESSION; METHYLATION | Adenocarcinoma; Colonic Neoplasms; Humans; MicroRNAs; Multiomics; messenger RNA; microRNA; transforming growth factor beta; alpha-methoxy-alpha-phenylacetic acid; microRNA; analytical parameters; Article; clinical feature; cohort analysis; colon adenocarcinoma; controlled study; gene expression; high throughput analysis; human; metabolic regulation; methylation; multiomics; multiomics enrichment score; multiomics pathway analysis; omics contribution rate; scoring system; solid malignant neoplasm; TGF beta signaling; adenocarcinoma; colon tumor; genetics | English | 2023 | 2023-03-16 | 10.1371/journal.pone.0278272 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Multilocus genotyping of Giardia duodenalis in pre-weaned calves with diarrhea in the Republic of Korea | Giardia duodenalis is a protozoan parasite that infects humans, companion animals, livestock, and wildlife. Infections in cattle caused by this parasite are often asymptomatic, but such infections can cause diarrhea, reduced weight gain, and ill-thrift in young calves. Although G. duodenalis causes diarrhea in calves, only a few studies have been conducted on calves in the Republic of Korea (ROK). Here, we aimed to determine the prevalence and distribution of G. duodenalis assemblages in pre-weaned calves with diarrhea in the ROK, identify the association between the occurrence of G. duodenalis and the age of calf, and perform molecular characterization of G. duodenalis. We collected 455 fecal samples from pre-weaned native Korean calves (<= 60 days old) with diarrhea in four different regions. G. duodenalis was detected using nested PCR targeting the beta-giardin (bg) gene, and positive samples were further genotyped for the glutamate dehydrogenase (gdh) and triosephosphate isomerase (tpi) genes. The overall prevalence of G. duodenalis in calves with diarrhea was 4.4% (20/455) based on the analysis of bg. The highest prevalence was observed in calves aged 11-30 days (7.5%; 95% confidence interval: 3.7%-11.3%), whereas the lowest prevalence was observed in neonatal calves. From the 20 samples that were positive for bg, 16, 5, and 6 sequences were obtained following genotyping of bg, gdh, and tpi, respectively. Sequencing analysis of the bg gene revealed the presence of assemblage E (n = 15) and sub-assemblage AI (n = 1) in the samples. Moreover, we detected mixed infections with assemblages E and A in two calves for the first time. Among the sequences obtained herein, two new subtypes of assemblage E were detected in gdh and tpi sequences each. The results suggest that G. duodenalis is an infectious agent causing diarrhea in calves, and pre-weaned calves are at a higher risk of infection than neonatal calves. Multilocus genotyping should be performed to confirm the presence of potentially zoonotic genotypes. These results highlight the importance of cattle as a source of zoonotic transmission of G. duodenalis to humans. | Park, Yu-Jin; Cho, Hyung-Chul; Jang, Dong-Hun; Park, Jinho; Choi, Kyoung-Seong | Kyungpook Natl Univ, Coll Ecol & Environm Sci, Dept Anim Sci & Biotechnol, Sangju, South Korea; Jeonbuk Natl Univ, Coll Vet Med, Iksan, South Korea | 57219426539; 57219427000; 57219426751; 8730126700; 7403949556 | kschoi3@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 18 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 2.9 | 23.5 | 0.71 | 2025-06-25 | 5 | 6 | ASSEMBLAGE-E; DAIRY CALVES; MOLECULAR EPIDEMIOLOGY; GENETIC DIVERSITY; IDENTIFICATION; PREVALENCE; CRYPTOSPORIDIUM; INTESTINALIS; QINGHAI; HUMANS | Animals; Cattle; Diarrhea; Feces; Genotype; Giardia lamblia; Giardiasis; Glutamate Dehydrogenase; Humans; Multilocus Sequence Typing; Phylogeny; Prevalence; Republic of Korea; Triose-Phosphate Isomerase; glutamate dehydrogenase; triosephosphate isomerase; glutamate dehydrogenase; triosephosphate isomerase; Article; calf (bovine); controlled study; diarrhea; disease transmission; DNA extraction; gene amplification; gene sequence; genotype; genotyping; geographic distribution; Giardia intestinalis; microbiological examination; multilocus sequence typing; nested polymerase chain reaction; nonhuman; nucleotide sequence; nucleotide sequence; phylogenetic tree; phylogeny; polymerase chain reaction; prevalence; reliability; sequence analysis; South Korea; zoonosis; zoonotic transmission; animal; bovine; diarrhea; feces; genetics; giardiasis; human; parasitology; veterinary medicine | English | 2023 | 2023-01-13 | 10.1371/journal.pone.0279533 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | Article | Optimal management of renal cell carcinoma in octogenarians: Retrospective analysis using updated Korean Renal Cell Carcinoma (KORCC) database | Background There is few of optimal management guideline in elderly patients with renal cell carcinoma (RCC). To compare the survival outcomes of octogenarian RCC group and younger RCC group after surgery using nationwide multi-institutional database. Methods A total of 10,068 patients who underwent surgery for RCC were included in the current retrospective, multi-institutional study. A propensity score matching (PSM) analysis was conducted to control other confounding factors in analyzing survival outcomes of octogenarian and younger group RCCs. Kaplan-Meier curve analysis to calculate the survival estimates for cancer-specific survival (CSS) and overall survival (OS), and multivariate Cox-proportional hazard regression analyses to evaluate the significant variables associated with the survival outcomes were also performed. Results Both groups were well-balanced in all baseline characteristics. In a total cohort, Kaplan-Meier survival analysis showed a significantly decreased 5-year and 8-year CSS and OS in the octogenarian group compared with the younger group. However, in a PSM cohort, no significant differences were evident between the two groups in terms of CSS (5-year, 87.3% vs. 87.0%; 8-year, 82.2% vs. 78.9%, respectively, log-rank test, p = 0.964). In addition, age ≥ 80 years (HR, 1.199; 95% CI, 0.497–2.896, p = 0.686) was not a significant prognostic factor of CSS in a PSM cohort. Conclusions The octogenarian RCC group after surgery had comparable survival outcomes compared with younger group after PSM analysis. For the life expectancy of octogenarian is getting longer, active treatment is considerable in patients with good performance status. Copyright: © 2023 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | Kim, Jung Kwon; Jung, Gyoohwan; Kwak, Cheol; Jeong, Chang Wook; Kang, Seok Ho; Hong, Sung-Hoo; Kim, Yong-June; Chung, Jinsoo; Hwang, Eu Chang; Kwon, Tae Gyun; Byun, Seok-Soo | Department of Urology, Seoul National University Bundang Hospital, Seongnam, South Korea, Department of Urology, Seoul National University College of Medicine, Seoul, South Korea; Department of Urology, Hanyang University Seoul Hospital, Seoul, South Korea; Department of Urology, Seoul National University College of Medicine, Seoul, South Korea, Department of Urology, Seoul National University Hospital, Seoul, South Korea; Department of Urology, Seoul National University College of Medicine, Seoul, South Korea, Department of Urology, Seoul National University Hospital, Seoul, South Korea; Department of Urology, Korea University Anam Hospital, Seoul, South Korea; Department of Urology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea; Department of Urology, Chungbuk National University Hospital, Cheongju, South Korea; Department of Urology, Center for Prostate Cancer, National Cancer Center, Goyang, South Korea; Department of Urology, Chonnam National University Medical School, Gwangju, South Korea; Department of Urology, Kyungpook National University Chilgok Hospital, Daegu, South Korea; Department of Urology, Seoul National University Bundang Hospital, Seongnam, South Korea, Department of Medical Device Development, Seoul National University College of Medicine, Seoul, South Korea | 36447570600; 56720069800; 7005639032; 8879131000; 7405684686; 37030299600; 26422204800; 16678454900; 8441681300; 15073765400; 7004818488 | ssbyun@snubh.org; | PLoS ONE | PLOS ONE | 1932-6203 | 1932-6203 | 18 | 3 March | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 2.9 | 23.5 | 0.12 | 2025-06-25 | 1 | Aged; Aged, 80 and over; Carcinoma, Renal Cell; Humans; Kidney Neoplasms; Neoplasm Staging; Octogenarians; Prognosis; Republic of Korea; Retrospective Studies; creatinine; hemoglobin F; adult; aged; Article; body mass; cancer grading; cancer mortality; cancer patient; cancer prognosis; cancer specific survival; cancer staging; cancer surgery; cancer survival; clinical outcome; cohort analysis; comparative study; controlled study; disease free survival; estimated glomerular filtration rate; female; follow up; human; laparoscopy; life expectancy; major clinical study; male; middle aged; mortality; North Korea; operation duration; outcome assessment; overall survival; propensity score; radical nephrectomy; renal cell carcinoma; retrospective study; smoking; survival analysis; survival rate; tumor volume; very elderly; epidemiology; kidney tumor; pathology; prognosis; South Korea | English | Final | 2023 | 10.1371/journal.pone.0283483 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | The population genetic structure and phylogeographic dispersal of Nodularia breviconcha in the Korean Peninsula based on COI and 16S rRNA genes | A freshwater mussel, Nodularia breviconcha (Mollusca: Bivalvia: Unionida) is endemic to Korean Peninsula. It has recently been taxonomically reexamined and elevated from a subspecies of N. douglasiae to an independent species. But population genetic studies for the species have rarely been conducted. To explore the population genetic structure of N. breviconcha, the nucleotide sequences of cytochrome oxidase subunit I(COI) and 16S rRNA genes from 135 N. breviconcha individuals, including 52 from this study and 83 from Choi et al. (2020). We found 23 COI and 11 16S rRNA genes haplotypes. Phylogeny, TCS network, Principal coordinates analysis, and spatial analysis of molecular variance performed with COI gene indicated that there are exist three different genetic lineages in the N. breviconcha populations: West lineage, Southwest lineage, and Southeast lineage. According to the time calibrated phylogeny, they are likely to be diverged during the late Miocene (8-6 Ma). Geographical distribution patterns of the three genetic lineages may be related to the formation of Taebaek and Sobaek-Noryeong mountain ranges in the Korean Peninsula occurred during the Miocene (30-10 Ma). The present results of this study will be helpful not only for the conservation, but also for the exploration of the population genetic structure of endemic freshwater mussels in the Korean Peninsula. | Kim, Gyeongmin; Hwang, Ui Wook | Kyungpook Natl Univ, Teachers Coll, Dept Biol Educ, Daegu, South Korea; Kyungpook Natl Univ, Inst Phylogen & Evolut, Daegu, South Korea; Kyungpook Natl Univ, Sch Life Sci, Grad Sch, Daegu, South Korea; Kyungpook Natl Univ, Sch Ind Technol Adv, Dept Biomed Convergence Sci & Technol, Daegu, South Korea; Kyungpook Natl Univ, Inst Korean Herb Bio Convergence Promot, Daegu, South Korea; Phylomics Inc, Daegu, South Korea | Choi, Eun Hwa/HTN-1610-2023 | 57211378109; 35074015800 | uwhwang1@gmail.com; | PLOS ONE | PLOS ONE | 1932-6203 | 18 | 7 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 2.9 | 23.5 | 0.71 | 2025-06-25 | 6 | 6 | WATER; CYPRINIFORMES; TELEOSTEI; BIVALVIA; NEUTRALITY; UNIONOIDA; PHYLOGENY; MOLLUSCA; MUSSELS; GROWTH | Genes, rRNA; Humans; Nodularia; Nodularia, bivalves; Phylogeography; Republic of Korea; RNA, Ribosomal, 16S; cytochrome c oxidase; RNA 16S; RNA 16S; 16S rRNA gene; Article; calibration; cell lineage; COI gene; endemic disease; freshwater species; gene structure; genetic analysis; genetic conservation; genetic variability; geographic distribution; haplotype; Miocene; mountain; Nodularia; Nodularia breviconcha; nonhuman; nucleotide sequence; phylogeny; phylogeography; population dispersal; population genetics; principal coordinate analysis; South Korea; spatial analysis; time; Unionidae; Upper Miocene; genetics; human; phylogeography; RNA gene | English | 2023 | 2023-07-12 | 10.1371/journal.pone.0288518 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | The relative importance of friendship to happiness increases with age | Happiness is predicted by social relationships in general and contact frequency in particular. This study aims to examine if the relative importance of social contacts with the closest family/relative, friend, and neighbor in happiness changes with advancing age. We used data for all participants aged 19 years and older (n = 229,099) in the 2019 Community Health Survey, which measured the frequency of contact with the closest relative/family, neighbor, and friend among a representative sample of Koreans between August 16 and October 31, 2019. The Shapley value decomposition method was used to measure the relative importance of each predictor of happiness. Overall, contact frequency was positively associated with happiness (p<0.001). The relative importance value of contact with the closest family, neighbor, and friend to happiness increased from 4.70%, 3.98%, and 7.35%, respectively, in the 19-29 years group to 8.09%, 4.44%, and 11.00%, respectively, in the 60 years and older group. Frequent interactions with the closest friend could have a greater impact on happiness in old age than those with the closest family and neighbor. | Song, Inmyung; Kwon, Jin-Won; Jeon, Soo Min | Kongju Natl Univ, Dept Hlth Adm, Gongju, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, BK21 Four Community Based Intelligent Novel Drug D, Daegu, South Korea; Jeju Natl Univ, Jeju Res Inst Pharmaceut Sci, Coll Pharm, Jeju, South Korea | ; Song, Inmyung/J-8250-2016 | 57002230700; 16202951700; 57206855645 | soomin0108@naver.com; | PLOS ONE | PLOS ONE | 1932-6203 | 18 | 7 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 2.9 | 23.5 | 0.24 | 2025-06-25 | 3 | 2 | WELL; OLDER; SUPPORT; HEALTH; FAMILY | Friends; Happiness; Health Surveys; Humans; Interpersonal Relations; Surveys and Questionnaires; adult; article; decomposition; friend; friendship; happiness; health survey; human; Korean (people); major clinical study; public health; social behavior; young adult; friend; health survey; human relation; questionnaire | English | 2023 | 2023-07-13 | 10.1371/journal.pone.0288095 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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