연구성과로 돌아가기
2022 연구성과 (128 / 280)
※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ○ | ○ | Review | Anti-diabetic prospects of dietary bio-actives of millets and the significance of the gut microbiota: A case of finger millet | Finger millet (Eleusine coracana) is a staple food in several parts of the world because of its high nutritional value. In addition to its high nutrient content, finger millet contains numerous bioactive compounds, including polyphenol (10.2 mg/g TAE), flavonoid (5.54 mg/g CE), phytic acid (0.48%), and dietary fiber (15-20%). Polyphenols are known for their anti-oxidant and anti-diabetic role. Phytic acid, previously considered an anti-nutritive substance, is now regarded as a nutraceutical as it reduces carbohydrate digestibility and thus controls post-prandial glucose levels and obesity. Thus, finger millet is an attractive diet for patients with diabetes. Recent findings have revealed that the anti-oxidant activity and bio-accessibility of finger millet polyphenols increased significantly (P < 0.05) in the colon, confirming the role of the gut microbiota. The prebiotic content of finger millet was also utilized by the gut microbiota, such as Faecalibacterium, Eubacterium, and Roseburia, to generate colonic short-chain fatty acids (SCFAs), and probiotic Bifidobacterium and Lactobacillus, which are known to be anti-diabetic in nature. Notably, finger millet-induced mucus-degrading Akkermansia muciniphila can also help in alleviate diabetes by releasing propionate and Amuc₁₁₀₀ protein. Various millet bio-actives effectively controlled pathogenic gut microbiota, such as Shigella and Clostridium histolyticum, to lower gut inflammation and, thus, the risk of diabetes in the host. In the current review, we have meticulously examined the role of gut microbiota in the bio-accessibility of millet compounds and their impact on diabetes. | Singh, Vineet; Lee, GyuDae; Son, HyunWoo; Amani, Sliti; Baunthiyal, Mamta; Shin, Jae-Ho | Kyungpook Natl Univ, Dept Appl Biosci, Daegu, South Korea; Govind Ballabh Pant Inst Engn & Technol, Dept Biotechnol, Ghurdauri, India | Baunthiyal, Mamta/K-4300-2019; Singh, Vineet/ABC-7000-2021; shin, Jaeho/K-6792-2013 | 57211642447; 57222101785; 57218872919; 58044658900; 55249938900; 57224125922 | mamtabaunthiyal@yahoo.co.in;jhshin@knu.ac.kr; | FRONTIERS IN NUTRITION | FRONT NUTR | 2296-861X | 9 | SCIE | NUTRITION & DIETETICS | 2022 | 5 | 31.2 | 0.99 | 2025-06-25 | 17 | 25 | bio accessibility; gut microbes; obesity; diabetes; insulin resistance; inflammation; endotoxemia; finger millet | CHAIN FATTY-ACIDS; PROTEIN-COUPLED RECEPTOR; ELEUSINE-CORACANA; ANTIOXIDANT ACTIVITY; LIPID-METABOLISM; INSULIN-RESISTANCE; OXIDATIVE STRESS; FERULIC ACID; GALLIC ACID; SHIGA TOXIN | bio accessibility; diabetes; endotoxemia; finger millet; gut microbes; inflammation; insulin resistance; obesity | English | 2022 | 2022-12-22 | 10.3389/fnut.2022.1056445 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Basal Autophagy Is Necessary for A Pharmacologic PPARα Transactivation | Autophagy is a conserved cellular process of catabolism leading to nutrient recycling upon starvation and maintaining tissue and energy homeostasis. Tissue-specific loss of core-autophagy-related genes often triggers diverse diseases, including cancer, neurodegeneration, inflammatory disease, metabolic disorder, and muscle disease. The nutrient-sensing nuclear receptors peroxisome proliferator-activated receptor alpha (PPAR alpha) plays a key role in fasting-associated metabolisms such as autophagy, fatty acid oxidation, and ketogenesis. Here we show that autophagy defects impede the transactivation of PPAR alpha. Liver-specific ablation of the Atg7 gene in mice showed reduced expression levels of PPAR alpha target genes in response to its synthetic agonist ligands. Since NRF2, an antioxidant transcription factor, is activated in autophagy-deficient mice due to p62/SQSTM1 accumulation and its subsequent interaction with KEAP1, an E3 ubiquitin ligase. We hypothesize that the nuclear accumulation of NRF2 by autophagy defects blunts the transactivation of PPAR alpha. Consistent with this idea, we find that NRF2 activation is sufficient to inhibit the pharmacologic transactivation of PPAR alpha, which is dependent on the Nrf2 gene. These results reveal an unrecognized requirement of basal autophagy for the transactivation of PPAR alpha by preventing NRF2 from a nuclear translocation and suggest a clinical significance of basal autophagy to expect a pharmacologic efficacy of synthetic PPAR alpha ligands. | Kim, Eun Young; Lee, Jae Man | Kyungpook Natl Univ, Dept Biochem & Cell Biol, Cell & Matrix Res Inst, Sch Med, Daegu 41944, South Korea; Kyungpook Natl Univ, BK21 FOUR KNU Biomed Convergence Program, Dept Biomed Sci, Grad Sch, Daegu 41944, South Korea | ; Lee, Jae/KFF-5361-2024; Kim, YoungHwan/B-2395-2013 | 57194632567; 47461355200 | key11@knu.ac.kr;jaemanlee@knu.ac.kr; | CELLS | CELLS-BASEL | 2073-4409 | 11 | 4 | SCIE | CELL BIOLOGY | 2022 | 6 | 31.2 | 0.06 | 2025-06-25 | 2 | 2 | basal autophagy; PPAR alpha; ATG7; NRF2; KEAP1; transactivation; gene expression | TRANSCRIPTION FACTOR NRF2; BETA-CELL MASS; SELECTIVE AUTOPHAGY; GENE-EXPRESSION; LIVER; MICE; IDENTIFICATION; SULFORAPHANE; HOMEOSTASIS; DELETION | ATG7; Basal autophagy; Gene expression; KEAP1; NRF2; PPARα; Transactivation | Animals; Autophagy; Kelch-Like ECH-Associated Protein 1; Ligands; Mice; NF-E2-Related Factor 2; PPAR alpha; Transcriptional Activation; autophagy related protein 7; kelch like ECH associated protein 1; peroxisome proliferator activated receptor alpha; sequestosome 1; transcription factor; trizol; ubiquitin protein ligase E3; kelch like ECH associated protein 1; ligand; peroxisome proliferator activated receptor alpha; transcription factor Nrf2; AML12 cell line; animal cell; animal experiment; animal model; Article; autophagy (cellular); C57BL 6 mouse; cell culture; controlled study; electrochemiluminescence; female; gene expression; immunoblotting; male; mouse; nonhuman; protein expression level; real time polymerase chain reaction; transactivation; Western blotting; wild type mouse; animal; autophagy; genetics; metabolism; physiology; transcription initiation | English | 2022 | 2022-02 | 10.3390/cells11040754 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | cAMP Signaling in Cancer: A PKA-CREB and EPAC-Centric Approach | Cancer is one of the most common causes of death globally. Despite extensive research and considerable advances in cancer therapy, the fundamentals of the disease remain unclear. Understanding the key signaling mechanisms that cause cancer cell malignancy may help to uncover new pharmaco-targets. Cyclic adenosine monophosphate (cAMP) regulates various biological functions, including those in malignant cells. Understanding intracellular second messenger pathways is crucial for identifying downstream proteins involved in cancer growth and development. cAMP regulates cell signaling and a variety of physiological and pathological activities. There may be an impact on gene transcription from protein kinase A (PKA) as well as its downstream effectors, such as cAMP response element-binding protein (CREB). The position of CREB downstream of numerous growth signaling pathways implies its oncogenic potential in tumor cells. Tumor growth is associated with increased CREB expression and activation. PKA can be used as both an onco-drug target and a biomarker to find, identify, and stage tumors. Exploring cAMP effectors and their downstream pathways in cancer has become easier using exchange protein directly activated by cAMP (EPAC) modulators. This signaling system may inhibit or accelerate tumor growth depending on the tumor and its environment. As cAMP and its effectors are critical for cancer development, targeting them may be a useful cancer treatment strategy. Moreover, by reviewing the material from a distinct viewpoint, this review aims to give a knowledge of the impact of the cAMP signaling pathway and the related effectors on cancer incidence and development. These innovative insights seek to encourage the development of novel treatment techniques and new approaches. | Ahmed, Muhammad Bilal; Alghamdi, Abdullah A. A.; Ul Islam, Salman; Lee, Joon-Seok; Lee, Young-Sup | Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea; Albaha Univ, Fac Sci, Dept Biol, Albaha 65779, Saudi Arabia; Cecos Univ, Dept Pharm, St 1,Sect 5 Phase 6 Hayatabad, Peshawar 25000, Pakistan | LEE, JIN/Q-3108-2018; Alghamdi, Abdullah/AEO-0020-2022; Ahmed, Muhammad/ABA-8180-2021 | 58689879600; 57410884000; 56985186700; 56496041000; 36013628200 | mbilalknu@gmail.com;aaa.alghamdi@bu.edu.sa;salmanulislam@cecos.edu.pk;joonseok74@naver.com;yselee@knu.ac.kr; | CELLS | CELLS-BASEL | 2073-4409 | 11 | 13 | SCIE | CELL BIOLOGY | 2022 | 6 | 31.2 | 2.93 | 2025-06-25 | 74 | 81 | cAMP; PKA; CREB; EPAC; tumor cell | PROTEIN-KINASE-A; ELEMENT-BINDING PROTEIN; HUMAN BREAST-CANCER; FIBRILLARY ACIDIC PROTEIN; SOLUBLE ADENYLYL-CYCLASE; MELANOMA-CELL MIGRATION; GENOME-WIDE ANALYSIS; NF-KAPPA-B; CYCLIC-AMP; PROSTATE-CANCER | cAMP; CREB; EPAC; PKA; tumor cell | Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Guanine Nucleotide Exchange Factors; Humans; Neoplasms; Signal Transduction; antiporter; biological marker; carcinoembryonic antigen; cisplatin; cyclic AMP dependent protein kinase; cyclic AMP responsive element binding protein; cyclin dependent kinase 4; flavonoid; microphthalmia associated transcription factor; microRNA; milrinone; mitogen activated protein kinase 1; osteocalcin; phosphatidylinositol 3 kinase; small interfering RNA; transcriptome; vasodilator stimulated phosphoprotein; cyclic AMP; cyclic AMP dependent protein kinase; guanine nucleotide exchange factor; acute myeloid leukemia; aerobic glycolysis; Akt/mTOR signaling; behavioral stress; breast cancer; breast carcinoma; bronchus carcinoid; cAMP signaling; carcinogenesis; cell cycle arrest; cell differentiation; cell migration; cell proliferation; cell survival; colon cancer; colorectal cancer; DNA damage; endometriosis; erectile dysfunction; fatigue; gene overexpression; glycolysis; head and neck cancer; head and neck squamous cell carcinoma; heart failure; human; immunoprecipitation; MAPK signaling; marine environment; neoplasm; oncolytic virotherapy; overall survival; pancreas cancer; prostate cancer; protein phosphorylation; radiosensitivity; regulatory T lymphocyte; renal cell carcinoma; Review; RNA interference; signal transduction; stomach cancer; tumor growth; tumor suppressor gene; ubiquitination; upregulation; Wnt signaling; metabolism | English | 2022 | 2022-07 | 10.3390/cells11132020 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Carnitine Protects against MPP⁺-Induced Neurotoxicity and Inflammation by Promoting Primary Ciliogenesis in SH-SY5Y Cells | Primary cilia help to maintain cellular homeostasis by sensing conditions in the extracellular environment, including growth factors, nutrients, and hormones that are involved in various signaling pathways. Recently, we have shown that enhanced primary ciliogenesis in dopamine neurons promotes neuronal survival in a Parkinson's disease model. Moreover, we performed fecal metabolite screening in order to identify several candidates for improving primary ciliogenesis, including L-carnitine and acetyl-L-carnitine. However, the role of carnitine in primary ciliogenesis has remained unclear. In addition, the relationship between primary cilia and neurodegenerative diseases has remained unclear. In this study, we have evaluated the effects of carnitine on primary ciliogenesis in 1-methyl-4-phenylpyridinium ion (MPP+)-treated cells. We found that both L-carnitine and acetyl-L-carnitine promoted primary ciliogenesis in SH-SY5Y cells. In addition, the enhancement of ciliogenesis by carnitine suppressed MPP+-induced mitochondrial reactive oxygen species overproduction and mitochondrial fragmentation in SH-SY5Y cells. Moreover, carnitine inhibited the production of pro-inflammatory cytokines in MPP+-treated SH-SY5Y cells. Taken together, our findings suggest that enhanced ciliogenesis regulates MPP+-induced neurotoxicity and inflammation. | Bae, Ji-Eun; Kim, Joon Bum; Jo, Doo Sin; Park, Na Yeon; Kim, Yong Hwan; Lee, Ha Jung; Kim, Seong Hyun; Kim, So Hyun; Son, Mikyung; Kim, Pansoo; Ryu, Hong-Yeoul; Lee, Won Ha; Ryoo, Zae Young; Lee, Hyun-Shik; Jung, Yong-Keun; Cho, Dong-Hyung | Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 Four KNU Creat BioRes Grp, Daegu 41566, South Korea; ORGASIS Corp, 260 Changyong Daero, Suwon 16229, South Korea; Gyeonggido Business & Sci Accelerator, Bioctr, Suwon 16229, South Korea; Seoul Natl Univ, Sch Biol Sci, Seoul 08826, South Korea | KIM, SUNG/ADF-8559-2022; Choi, Hye Rin/JDV-9065-2023; Kim, Seong Cheol/ABD-1493-2022; Kim, Joon/ADP-8066-2022; RYOO, ZAEYOUNG/AAQ-1573-2020 | 57190605352; 57190611030; 56335489800; 57190609826; 57204676401; 57221856423; 57253406700; 57253406800; 57880088000; 56577113700; 55889917800; 57205609794; 16937104900; 16316010200; 35358575000; 35093684400 | dhcho@knu.ac.kr; | CELLS | CELLS-BASEL | 2073-4409 | 11 | 17 | SCIE | CELL BIOLOGY | 2022 | 6 | 31.2 | 0.75 | 2025-06-25 | 11 | 12 | primary cilia; L-carnitine; acetyl-L-carnitine; MPP+; Mitochondria; SH-SY5Y cells | ACETYL-L-CARNITINE; PRIMARY CILIA; BRAIN-INJURY; DISEASE; MODEL | acetyl-L-carnitine; L-carnitine; Mitochondria; MPP<sup>+</sup>; primary cilia; SH-SY5Y cells | carnitine; interleukin 6; reactive oxygen metabolite; tumor necrosis factor; Article; cell culture; cell survival; cell viability; clinical article; cytotoxicity; endoplasmic reticulum stress; enzyme linked immunosorbent assay; fluorescence microscopy; gene expression; gene knockdown; genetic transfection; homeostasis; human; human cell; immunocytochemistry; inflammation; mitochondrion; mouse; MPP+-induced neurotoxicity; neurotoxicity; primary cilium; protein homeostasis; SH-SY5Y cell line; signal transduction; Western blotting | English | 2022 | 2022-09 | 10.3390/cells11172722 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Cathelicidin-Related Antimicrobial Peptide Negatively Regulates Bacterial Endotoxin-Induced Glial Activation | Recent studies have suggested that mouse cathelicidin-related antimicrobial peptide (CRAMP) and its human homologue leucine leucine-37 (LL-37) play critical roles in innate immune responses. Here, we studied the role of mouse CRAMP in bacterial endotoxin lipopolysaccharide (LPS)-induced neuroinflammation. CRAMP peptide treatment significantly inhibited LPS-mediated inflammatory activation of glial cells in culture. In the animal model of LPS-induced neuroinflammation, CRAMP expression was highly induced in multiple cell types, such as astrocytes, microglia, and neurons. Injection of exogenous CRAMP peptide significantly inhibited inflammatory cytokine expression and the reactivity of glial cells in the mouse brain following intraperitoneal or intracerebroventricular LPS administration. Altogether, results of the study suggest that CRAMP plays an important part in containment of LPS-induced neuroinflammatory responses, and that CRAMP can be exploited for the development of targeted therapies for neuroinflammatory conditions associated with bacterial infection. | Bhusal, Anup; Nam, Youngpyo; Seo, Donggun; Lee, Won-Ha; Suk, Kyoungho | Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, Plus KNU Biomed Convergence Program BK21, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Life Sci, KNU Creat Biores Grp BK21 4, Daegu 41566, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41944, South Korea | 57200274141; 55143100300; 57207584467; 57205609794; 7005114595 | ksuk@knu.ac.kr; | CELLS | CELLS-BASEL | 2073-4409 | 11 | 23 | SCIE | CELL BIOLOGY | 2022 | 6 | 31.2 | 0.25 | 2025-06-25 | 4 | 4 | CRAMP; LPS; microglia; astrocyte; neuroinflammation | LL-37; DEFENSE; LPS; EXPRESSION; RECEPTOR | astrocyte; CRAMP; LPS; microglia; neuroinflammation | Animals; Antimicrobial Cationic Peptides; Humans; Leucine; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Microglia; cytokine; endotoxin; gamma interferon inducible protein 10; lipopolysaccharide; nitric oxide; ropocamptide; tumor necrosis factor; antimicrobial cationic peptide; leucine; lipopolysaccharide; adult; animal cell; animal experiment; animal model; animal tissue; Article; astrocyte; cell viability; controlled study; enzyme linked immunosorbent assay; glia cell; hippocampus; immunofluorescence; innate immunity; lipopolysaccharide-induced neuroinflammation; male; microglia; molecularly targeted therapy; mouse; MTT assay; nerve cell; nervous system inflammation; nonhuman; protein expression; protein function; real time polymerase chain reaction; X ray diffraction; animal; C57BL mouse; human; metabolism; microglia | English | 2022 | 2022-12 | 10.3390/cells11233886 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | DICAM in the Extracellular Vesicles from Astrocytes Attenuates Microglia Activation and Neuroinflammation | Cross-talk between astrocytes and microglia plays an important role in neuroinflammation and central sensitization, but the manner in which glial cells interact remains less well-understood. Herein, we investigated the role of dual immunoglobulin domain-containing cell adhesion molecules (DICAM) in the glial cell interaction during neuroinflammation. DICAM knockout (KO) mice revealed enhanced nociceptive behaviors and glial cell activation of the tibia fracture with a cast immobilization model of complex regional pain syndrome (CRPS). DICAM was selectively secreted in reactive astrocytes, mainly via extracellular vesicles (EVs), and contributed to the regulation of neuroinflammation through the M2 polarization of microglia, which is dependent on the suppression of p38 MAPK signaling. In conclusion, DICAM secreted from reactive astrocytes through EVs was involved in the suppression of microglia activation and subsequent attenuation of neuroinflammation during central sensitization. | Han, Jin; Cho, Hyun-Jung; Park, Donghwi; Han, Seungwoo | Kyungpook Natl Univ, Res Inst Aging & Metab, Lab Arthrit & Cartilage Biol, Daegu 41404, South Korea; Daegu Fatima Hosp, Fatima Res Inst, Lab Arthrit & Bone Biol, Daegu 41404, South Korea; Univ Ulsan, Ulsan Univ Hosp, Dept Phys Med & Rehabil, Coll Med, Ulsan 44521, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Rheumatol, Daegu 41404, South Korea | Han, Seungwoo/R-5326-2019; Park, Donghwi/GYQ-6185-2022 | 57218360938; 57191496377; 56606561400; 55246807000 | bdome@uuh.ulsan.kr;kiefe73@gmail.com; | CELLS | CELLS-BASEL | 2073-4409 | 11 | 19 | SCIE | CELL BIOLOGY | 2022 | 6 | 31.2 | 0.56 | 2025-06-25 | 9 | 9 | DICAM; neuroinflammation; astrocyte; microglia; CRPS; extracellular vesicle | REGIONAL PAIN SYNDROME; CENTRAL SENSITIZATION; MECHANICAL ALLODYNIA; MOUSE MODEL; P38 MAPK; CELLS; GLIA | astrocyte; CRPS; DICAM; extracellular vesicle; microglia; neuroinflammation | Animals; Astrocytes; Cell Adhesion Molecules; Extracellular Vesicles; Mice; Mice, Knockout; Microglia; Neuroinflammatory Diseases; p38 Mitogen-Activated Protein Kinases; CD163 antigen; CD68 antigen; cell adhesion molecule; cyclooxygenase 2; gamma interferon; immunoglobulin enhancer binding protein; inducible nitric oxide synthase; interleukin 10; interleukin 13; interleukin 1beta; interleukin 4; interleukin 6; messenger RNA; mitogen activated protein kinase 14; mitogen activated protein kinase p38; toll like receptor 3; toll like receptor 4; tumor necrosis factor; cell adhesion molecule; DICAM protein, mouse; mitogen activated protein kinase p38; animal cell; animal experiment; animal model; animal tissue; Article; astrocyte; cell adhesion; cell interaction; cell viability; complex regional pain syndrome; controlled study; cytokine production; disease duration; enzyme linked immunosorbent assay; exosome; female; flow cytometry; forced swim test; gene expression; heart fibroblast; immobilization; immunoblotting; immunofluorescence; immunohistochemistry; inflammation; innate immunity; male; MAPK signaling; mechanical stimulation; microglia; mouse; nervous system inflammation; nonhuman; numeric rating scale; pain intensity; phenotype; polarization; polymerase chain reaction; protein expression; protein phosphorylation; real time polymerase chain reaction; rotarod test; signal transduction; Spontaneous Weight Bearing Test; T lymphocyte; upregulation; von Frey test; Western blotting; animal; knockout mouse; metabolism; microglia | English | 2022 | 2022-10 | 10.3390/cells11192977 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Different Expression of Thyroid-Specific Proteins in Thyroid Cancer Cells between 2-Dimensional (2D) and 3-Dimensional (3D) Culture Environment | The two-dimensional (2D) monolayer culture as a conventional method has been widely applied in molecular biology fields, but it has limited capability to recapitulate real cell environments, being prone to misinterpretation with poor prediction of in vivo behavior. Recently, the three-dimensional (3D) spheroid culture has been studied extensively. Spheroids are self-assembled cell aggregates that have biomimicry capabilities. The behavior of thyroid cancer under the 3D spheroid culture environment has been studied; however, there are no reports regarding differences in the degree of thyroid cancer cell differentiation under 2D and 3D culture conditions. This study investigated the expression of thyroid differentiation proteins related to iodide-metabolizing mechanisms in thyroid cancer cells under different culture conditions. Four thyroid cancer cell lines and one thyroid follicular epithelial cell line were grown in adherent 2D cell culture and 3D spheroid culture with agarose-coated plates. We observed changes in proliferation, hypoxia, extracellular matrix (ECM), cytoskeleton, thyroid-specific proteins, and thyroid transcription factors. All cell lines were successfully established in the spheroid following cell aggregation. Proliferation considerably decreased, while hypoxia-inducible factor 1-alpha(HIF1-alpha) was promoted in 3D spheroids; moreover, 3D spheroids with thyroid cancers showed diminished thyroid differentiation markers, but thyroid follicular epithelial cells revealed either a maintenance or weak decline of protein expression. We verified that the 3D spheroid culture environment can be similar to in vivo conditions because of its alterations in numerous cellular and functional activities, including morphology, cellular proliferation, viability, hypoxia, ECM, cytoskeleton, and thyroid differentiation, compared to the conventional 2D monolayer culture environment. An in vitro experimental study using 3D spheroid culture is ideal for the faster discovery of new drugs. | Oh, Ji Min; Gangadaran, Prakash; Rajendran, Ramya Lakshmi; Hong, Chae Moon; Lee, Jaetae; Ahn, Byeong-Cheol | Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu 41944, South Korea | ; Rajendran, Ramya/AAV-6338-2021; Gangadaran, Prakash/AAV-3102-2021 | 57190370462; 54393130400; 57195318729; 37050876700; 7601451907; 7202791511 | abc2000@knu.ac.kr; | CELLS | CELLS-BASEL | 2073-4409 | 11 | 22 | SCIE | CELL BIOLOGY | 2022 | 6 | 31.2 | 0.56 | 2025-06-25 | 7 | 9 | thyroid cancers; 3-dimensional culture; Thyroid differentiation; Hypoxia | SODIUM-IODIDE SYMPORTER; GENE-EXPRESSION; IN-VITRO; HYPOXIA; SYSTEMS; RESISTANCE; SPHEROIDS; PLATFORMS; INDUCTION; GROWTH | 3-dimensional culture; Hypoxia; thyroid cancers; Thyroid differentiation | Cell Culture Techniques; Humans; Hypoxia; Spheroids, Cellular; Thyroid Neoplasms; adenosine triphosphate; beta actin; cycline; eosin; hematoxylin; homeobox protein Nkx 2.1; hypoxia inducible factor 1; protein; sodium iodide symporter; thyroglobulin; thyroid peroxidase; thyroid specific protein; unclassified drug; 8505C cell line; antigen retrieval; Article; B-CPAP cell line; BHP10-3SCp Cell lie; BHT-101 cell line; CAL-62 cell line; cell aggregation; cell differentiation; cell proliferation; cell proliferation assay; cell structure; confocal laser scanning microscopy; controlled study; cytoskeleton; epithelial cell line; extracellular matrix; HTh7 cell line; human; human cell; human tissue; hypoxia; immunofluorescence; immunohistochemistry; microscopy; monolayer culture; Nthy-ori 3-1 cell line; polyacrylamide gel electrophoresis; protein expression; radioimmunoprecipitation; SW1736 cell line; three dimensional cell culture; three dimensional Spheroid Cell Culture; thyroid cancer; thyroid papillary carcinoma cell line; TPC-1 cell line; two dimensional cell culture; Western blotting; cell culture technique; multicellular spheroid; procedures; thyroid tumor | English | 2022 | 2022-11 | 10.3390/cells11223559 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Endophyte-Mediated Stress Tolerance in Plants: A Sustainable Strategy to Enhance Resilience and Assist Crop Improvement | Biotic and abiotic stresses severely affect agriculture by affecting crop productivity, soil fertility, and health. These stresses may have significant financial repercussions, necessitating a practical, cost-effective, and ecologically friendly approach to lessen their negative impacts on plants. Several agrochemicals, such as fertilizers, pesticides, and insecticides, are used to improve plant health and protection; however, these chemical supplements have serious implications for human health. Plants being sessile cannot move or escape to avoid stress. Therefore, they have evolved to develop highly beneficial interactions with endophytes. The targeted use of beneficial plant endophytes and their role in combating biotic and abiotic stresses are gaining attention. Therefore, it is important to experimentally validate these interactions and determine how they affect plant fitness. This review highlights research that sheds light on how endophytes help plants tolerate biotic and abiotic stresses through plant-symbiont and plant-microbiota interactions. There is a great need to focus research efforts on this vital area to achieve a system-level understanding of plant-microbe interactions that occur naturally. | Kamran, Muhammad; Imran, Qari Muhammad; Ahmed, Muhammad Bilal; Falak, Noreen; Khatoon, Amna; Yun, Byung-Wook | Univ Western Australia, Sch Mol Sci, M310,35 Stirling Hwy, Perth, WA 6009, Australia; Umea Univ, Dept Med Biochem & Biophys, S-90187 Umea, Sweden; Kyungpook Natl Univ, Coll Agr & Life Sci, Div Plant Biosci, Lab Plant Mol Pathol & Funct Genom, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea; Kohat Univ Sci & Technol, Dept Bot, Kohat 26000, Pakistan | Imran, Qari Muhammad/ABG-6074-2022; Ahmed, Muhammad/ABA-8180-2021; Kamran, Muhammad/C-8121-2018 | 57462900300; 55849263700; 58689879600; 57188737693; 59475147500; 8245123600 | muhammad.kamran@uwa.edu.au;bwyun@knu.ac.kr; | CELLS | CELLS-BASEL | 2073-4409 | 11 | 20 | SCIE | CELL BIOLOGY | 2022 | 6 | 31.2 | 2.05 | 2025-06-25 | 40 | 57 | endophytes; plant defense; drought; salinity; temperature; crop improvement | GROWTH-PROMOTING RHIZOBACTERIA; SPHINGOMONAS SP LK11; DROUGHT STRESS; SYSTEMIC RESISTANCE; FUNGAL ENDOPHYTES; SALT TOLERANCE; BACTERIAL ENDOPHYTES; TRITICUM-AESTIVUM; OSMOTIC-STRESS; JASMONIC ACID | crop improvement; drought; endophytes; plant defense; salinity; temperature | Endophytes; Fertilizers; Humans; Insecticides; Plants; Soil; fertilizer; insecticide; abiotic stress; Arabidopsis thaliana; Bacillus amyloliquefaciens; Bacillus cereus; Bacillus subtilis; biotic stress; Burkholderia; carbohydrate metabolism; crop improvement; drought; endophyte; Flavobacterium; Fusarium solani; Glomerella cingulata; Gluconacetobacter; Gluconacetobacter diazotrophicus; Klebsiella; microbial colonization; Nicotiana tabacum; nonhuman; Paenibacillus; Phaseolus vulgaris; physiological stress; Phytophthora; Phytophthora capsica; plant defense; plant microorganism interaction; plant stress; Pseudomonas aeruginosa; Pythium; Pythium myriotylum; Review; Rhizobium; salinity; systematic review; temperature; temperature stress; tomato; Triticum aestivum; human; plant; soil | English | 2022 | 2022-10 | 10.3390/cells11203292 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Endophytic fungus Bipolaris sp. CSL-1 induces salt tolerance in Glycine max.L via modulating its endogenous hormones, antioxidative system and gene expression | Salinity stress is one of the most serious environmental stress that inhibits plant growth. In this study, we adopted an environment friendly technique and screened different plant growth-promoting fungi for different plant growth promoting (PGP) traits and salinity stress. Among those isolates, Bipolaris sp. CSL-1 was selected based on plant growth-promoting characteristics, such as producing indole-3-acetic acid (IAA), gibberellins (GAs), organic acids and resistance to sodium chloride (NaCl) stress. Here, we found that inoculating soybean with isolate CSL-1 significantly increased shoot and root length, shoot and root fresh and dry weight and chlorophyll content under NaCl stress (200 mM). Endogenous abscisic acid (ABA) levels were significantly decreased, whereas salicylic acid (SA) levels were increased in CSL-1-inoculated plants under NaCl stress. NaCl-treated noninoculated plants showed higher levels of antioxidants and oxidative stress such as peroxidase, polyphenol oxidase (PPO), malondialdehyde (MDA) and superoxide anion (SOA). Furthermore, CSL-1 inoculation improved soybean resistance to NaCl stress, and there was a significant decrease in GmFDL19, GmNARK, and GmSIN1 expression levels. As a result, the fungal isolate CSL-1 mitigates the effect of salt stress and enhance soybean growth and might be used as a valuable ecofriendly microorganism resource in salt-affected areas. | Lubna; Khan, Muhammad Aaqil; Asaf, Sajjad; Jan, Rahmatullah; Waqas, Muhammad; Kim, Kyung-Min; Lee, In-Jung | Abdul Wali Khan Univ, Dept Bot, Mardan, Pakistan; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa, Oman; Govt Khyber Pakhtunkhwa, Dept Agr Extens, Mardan, Pakistan | ; Khan, Muhammad/ABB-9797-2021; Kim, Kyung-Min Kim/C-7007-2014; Jan, Rahmatullah/AIC-3439-2022; Lee, In-Jung/GLS-0432-2022; Asaf, Sajjad/ABA-3647-2021; Waqas, Muhammad/IYS-9931-2023 | 57200621537; 57188585606; 56595059900; 57201981969; 59139606000; 34868260300; 16425830900 | ijlee@knu.ac.kr; | JOURNAL OF PLANT INTERACTIONS | J PLANT INTERACT | 1742-9145 | 1742-9153 | 17 | 1 | SCIE | PLANT SCIENCES | 2022 | 3.2 | 31.2 | 4.13 | 2025-06-25 | 18 | 33 | Salinity stress; phytohormones; antioxidants; gene expression; isolate CSL-1 | ARBUSCULAR MYCORRHIZAL FUNGI; PLANT-GROWTH; SALINITY STRESS; SPHINGOMONAS SP; L.; RESPONSES; ROOT; RESISTANCE; DROUGHT; ACID | antioxidants; gene expression; isolate CSL-1; phytohormones; Salinity stress | English | 2022 | 2022-12-31 | 10.1080/17429145.2022.2036836 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Engineered Nanovesicles from Fibroblasts Modulate Dermal Papillae Cells In Vitro and Promote Human Hair Follicle Growth Ex Vivo | Alopecia is a common medical condition affecting both sexes. Dermal papilla (DP) cells are the primary source of hair regeneration in alopecia patients. Therapeutic applications of extracellular vesicles (EVs) are restricted by low yields, high costs, and their time-consuming collection process. Thus, engineered nanovesicles (eNVs) have emerged as suitable therapeutic biomaterials in translational medicine. We isolated eNVs by the serial extrusion of fibroblasts (FBs) using polycarbonate membrane filters and serial and ultracentrifugation. We studied the internalization, proliferation, and migration of human DP cells in the presence and absence of FB-eNVs. The therapeutic potential of FB-eNVs was studied on ex vivo organ cultures of human hair follicles (HFs) from three human participants. FB-eNVs (2.5, 5, 7.5, and 10 mu g/mL) significantly enhanced DP cell proliferation, with the maximum effect observed at 7.5 mu g/mL. FB-eNVs (5 and 10 mu g/mL) significantly enhanced the migration of DP cells at 36 h. Western blotting results suggested that FB-eNVs contain vascular endothelial growth factor (VEGF)-a. FB-eNV treatment increased the levels of PCNA, pAKT, pERK, and VEGF-receptor-2 (VEGFR2) in DP cells. Moreover, FB-eNVs increased the human HF shaft size in a short duration ex vivo. Altogether, FB-eNVs are promising therapeutic candidates for alopecia. | Rajendran, Ramya Lakshmi; Gangadaran, Prakash; Kwack, Mi Hee; Oh, Ji Min; Hong, Chae Moon; Jeyaraman, Madhan; Sung, Young Kwan; Lee, Jaetae; Ahn, Byeong-Cheol | Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Immunol, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu 41944, South Korea; Dr MGR Educ & Res Inst Univ, ACS Med Coll & Hosp, Dept Orthopaed, Chennai 600056, Tamil Nadu, India; Sharda Univ, Sch Engn & Technol, Dept Biotechnol, Greater Noida 201310, Uttar Pradesh, India | Lee, Jaetae/ABF-3980-2020; Gangadaran, Prakash/AAV-3102-2021; Jeyaraman, Madhan/ABB-8464-2020; Rajendran, Ramya/AAV-6338-2021 | 57195318729; 54393130400; 6507685557; 57190370462; 37050876700; 57216926503; 55663365300; 7601451907; 7202791511 | abc2000@knu.ac.kr; | CELLS | CELLS-BASEL | 2073-4409 | 11 | 24 | SCIE | CELL BIOLOGY | 2022 | 6 | 31.2 | 0.25 | 2025-06-25 | 4 | 4 | alopecia; dermal papilla; extracellular vesicles; engineered nanovesicles | EXTRACELLULAR VESICLES; PROLIFERATION; DELIVERY; ACTIVATION | alopecia; dermal papilla; engineered nanovesicles; extracellular vesicles | Alopecia; Cells, Cultured; Dermis; Female; Fibroblasts; Hair Follicle; Humans; Male; Vascular Endothelial Growth Factor A; biological marker; bone morphogenetic protein 2; calnexin; cycline; drug carrier; engineered nanovesicle; flotillin 1; golgi matrix protein 130; heat shock protein 90; lymphoid enhancer factor 1; messenger RNA; mitogen activated protein kinase; phosphoprotein; programmed cell death 6 interacting protein; protein kinase B; unclassified drug; vasculotropin A; vasculotropin receptor 2; vasculotropin A; alopecia; animal cell; Article; cell migration assay; cell proliferation assay; cellular uptake; cellular parameters; chemoluminescence; controlled study; dermal papillae cells; enhanced chemiluminescence; exosome; fibroblast; gene expression; hair follicle; hair follicle shaft size; hair growth; hair shaft elongation; human; human cell; internalization (cell); mouse; NCTC clone 929 cell line; nonhuman; organ culture; physical parameters; polyacrylamide gel electrophoresis; protein expression; real time polymerase chain reaction; RNA isolation; skin cell; transmission electron microscopy; ultracentrifugation; Western blotting; alopecia; cell culture; dermis; female; fibroblast; male; metabolism | English | 2022 | 2022-12 | 10.3390/cells11244066 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Er³⁺-doped SiO2-based glasses-An exploration of structural, visible, chromatic, and NIR fluorescence characteristics | SiO2-based glasses doped with 1 mol% Er3+ were fabricated via melt-quench process and their structural and visible and NIR (near-infrared) fluorescence features have been investigated. Calculated Judd-Ofelt (J-O) intensity parameters that were deduced from absorption spectra are applied to reckon different radiative factors. Visible emission spectra and decay profiles (for S-4(3/2) & RARR; I-4(15/2) transition) were registered upon lambda(exci.)= 379 nm. CIE (Commission International de I'Eclairage), CCT (correlated color temperature), and CP (color purity) values were evaluated from the emission spectra. Also, a NIR luminescence band (I-4(13/2) & RARR; I-4(15/2) transition) was identified by 980 nm LD (laser diode). Later, emission cross-section [(sigma(emi)) stimulated, (sigma(M)(emi)) from Mccumber theory] values were computed for observed NIR emission. Highest sigma(emi) and gain bandwidth (sigma(emi) x delta lambda(eff)) were obtained to be 9.18x10(-21) cm(2) and 517x10(-28) cm(3) accordingly for I-4(13/2) & RARR; I-4(15/2) transition. | Devarajulu, G.; Lakshminarayana, G.; Rao, P. Venkateswara; Lee, Dong-Eun; Yoon, Jonghun; Park, Taejoon | Kyungpook Natl Univ, Intelligent Construct Automat Ctr, 80 Daehak Ro, Daegu 41566, South Korea; Univ West Indies, Dept Phys, Mona Campus, Kingston 7, Jamaica; Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy, 1370 Sangyeok Dong, Daegu 702701, South Korea; Hanyang Univ, BK21 FOUR ERICA ACE Ctr, Dept Mech Engn, 55 Hanyangdaehak Ro, Ansan 15588, Gyeonggi Do, South Korea; Hanyang Univ, Dept Robot Engn, 55 Hanyangdaehak Ro, Ansan 15588, Gyeonggi Do, South Korea | Penugonda, Venkateswara/AAA-3956-2019; GELIJA, DEVARAJULU/S-8326-2017; Gelija, Devarajulu/S-8326-2017 | 57200322478; 57194637883; 58761927500; 56605563300; 56449838900; 55717001200 | gandham@knu.ac.kr;yoonesmd@gmail.com;taejoon@hanyang.ac.kr; | MATERIALS RESEARCH BULLETIN | MATER RES BULL | 0025-5408 | 1873-4227 | 147 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2022 | 5.4 | 31.2 | 1.99 | 2025-06-25 | 23 | 24 | <p>SiO2 glasses</p>; Er3+; J-O analysis; Color purity; C-optical band; NIR amplifier | OXYFLUORIDE SILICATE-GLASSES; DOPED PHOSPHATE-GLASS; OPTICAL BAND-GAP; SPECTROSCOPIC PROPERTIES; UP-CONVERSION; LUMINESCENCE PROPERTIES; THERMAL-STABILITY; MU-M; FIBER AMPLIFIERS; BORATE GLASSES | Color purity; C–optical band; Er<sup>3+</sup>; J–O analysis; NIR amplifier; SiO<sub>2</sub> glasses | Color; Emission spectroscopy; Erbium compounds; Fluorescence; Glass; Infrared devices; Color purity; C–optical band; Er3+; Judd-ofelt analysis; Near Infrared; Near-infrared; Near-infrared amplifier; Near-infrared fluorescence; Optical bands; SiO2 glass; Silica | English | 2022 | 2022-03 | 10.1016/j.materresbull.2021.111634 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Gibberellins hypersensitivity hinder the interaction of Bipolaris sorokiniana (Scc.) under cross talks with IAA and transzeatin | Gibberellins are considered to play an important role in modulating plant-pathogen interactions. In order to find this, we studied the effect of GA4 on the interactions of Bipolaris sorokiniana (Scc.) (BIPOL) with Triticum aestivum. After inoculating the roots of hydroponically grown T. avestivum with BIPOL, the GA4 level shot up by 26%. The increased level of GA4 elicited a hypersensitive response (HR) in the T. aestivum seedlings. The elicitation in HR was confirmed through measurement of HR-inducing signaling compounds (i.e. c-di-GMP, cAMP, phosphatidic acid, pure and esterified oxo-phytodeinoic acid, and jasmonic acid). The concentration of HR-inducing signaling compounds in the treated T. aestivum seedlings was 31% higher compared to the control seedlings. Moreover, the induced HR response lowered the indole-3-acetic acid (IAA) level by 15% and the transzeatin (TZn) level by 22%. However, the application of 10 mM uniconazole through aerial spray inhibited GA4 biosynthesis in T. aestivum seedlings. Also, BIPOL colonized the roots of T. aestivum seedlings after uniconazole treatment and promoted seedling growth through increased relative growth rate (14%) and net assimilation rate (27%). | Yousaf, Muhammad Junaid; Hussain, Anwar; Hamayun, Muhammad; Iqbal, Amjad; Lee, In-Jung | Abdul Wali Khan Univ Mardan, Dept Bot, Garden Campus, Khyber Pakhtunkhwa, Pakistan; Abdul Wali Khan Univ Mardan, Dept Food Sci Technol, Garden Campus, Khyber Pakhtunkhwa, Pakistan; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, Daegu, South Korea | Hussain, Anwar/N-1605-2019; Iqbal, Amjad/E-2010-2014; Lee, In-Jung/GLS-0432-2022; Hamayun, Muhammad/B-1694-2010 | 57739465900; 35621772200; 59297330100; 10142205100; 16425830900 | drhussain@awkum.edu.pk;ijlee@knu.edu.kr; | JOURNAL OF PLANT INTERACTIONS | J PLANT INTERACT | 1742-9145 | 1742-9153 | 17 | 1 | SCIE | PLANT SCIENCES | 2022 | 3.2 | 31.2 | 0.25 | 2025-06-25 | 2 | 2 | Plant-pathogen interactions; hormonal cross talks; hypersensitive response; growth activity; uniconazole | ACID; PATHOGEN; OXIDASE; PROTEIN; PLANTS; FOOD | growth activity; hormonal cross talks; hypersensitive response; Plant–pathogen interactions; uniconazole | English | 2022 | 2022-12-31 | 10.1080/17429145.2021.2018060 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Graduating to a gender wage gap in South Korea | Using data from the Graduates Occupational Mobility Survey and unconditional quantile regressions, this paper analyzes gender wage gaps among recent tertiary graduates in South Korea. Unconditional log wage gaps at the mean, 10th quantile and 90th quantile are 0.190, 0.146 and 0.239 which are at least half the size of the respective wage gaps among the general population. Aggregate decompositions show that composition effects are similar across the distribution while structural effects are larger further up the distribution, therefore driving wider gaps in high-wage positions. Detailed composition effects show that high school type, field of study, firm size and occupation explain at least 50% of the wage gaps. Major drivers include low rates of women in high school science tracks; university engineering courses; large firms; and manufacturing, sales and trade occupations as well as high rates of women in small firms and administrative, health and social welfare occupations. Lastly, the use of detailed categories for fields of study and occupations is shown to substantially increase the size of composition effects. | Tromp, Nikolas; Kwak, Juwon | Keimyung Univ, Dept Econ & Finance, Daegu, South Korea; Kyungpook Natl Univ, Dept Econ, Daegu, South Korea | 57209293230; 56400104500 | nikolas.tromp@gmail.com;juwonkwak@knu.ac.kr; | JOURNAL OF ASIAN ECONOMICS | J ASIAN ECON | 1049-0078 | 1873-7927 | 78 | SSCI | ECONOMICS | 2022 | 3.2 | 31.2 | 0.17 | 2025-06-25 | 2 | 2 | Gender wage gap; Tertiary graduates; South Korea; Distributional decompositions | DISCRIMINATION; DECOMPOSITION; PAY; UK | Distributional decompositions; Gender wage gap; South Korea; Tertiary graduates | English | 2022 | 2022-02 | 10.1016/j.asieco.2021.101408 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Growth and NO2 sensing properties of Cs2SnI6 thin film | In this study, Cs2SnI6 thin film was synthesized on a glass substrate through a two-step process using the chemical vapor deposition (CVD) method and was subsequently used as a NO2 gas sensor. First, the CsI spheres with an average diameter of 360 nm were fabricated on the glass substrate using a CVD system at 240 C. Second, Cs2SnI6 film was formed through the reaction of CsI spheres with SnI4 vapor at 200 degrees C for 1 h. Finally, the as-synthesized Cs2SnI6 thin film based gas sensor was then fabricated to explore its potential applications. The results indicated that the device showed good selectivity, stability, and detection for NO2 with low concentration at room temperature. In addition, the effect of humidity on NO2-sensing performance of the device was further studied. Furthermore, the NO2 sensing mechanism of the Cs2SnI6 thin film was discussed. Hence, this study helps understand the gas sensing mechanism of halide perovskite Cs2SnI6 and the room temperature development of NO2 gas sensors. | Hung, Pham Tien; Hoat, Phung Dinh; Nguyen, Tien-Anh; Van Thin, Pham; Hien, Vu Xuan; Lim, Hyo-Jun; Lee, Sangwook; Lee, Joon-Hyung; Heo, Young-Woo | Le Quy Don Tech Univ, Dept Phys, 236 Hoang Quoc Viet St, Hanoi, Vietnam; Kyungpook Natl Univ KNU, Sch Mat Sci & Engn, Daegu 41566, South Korea; Hanoi Univ Sci & Technol, Sch Engn Phys, 01 Dai Co Viet St, Hanoi, Vietnam; Kyungpook Natl Univ, KNU Adv Mat Res Inst, Daegu 41566, South Korea; Kyungpook Natl Univ KNU, 80 Daehakro,Buk Gu, Daegu, South Korea; E8-215, 80 Daehakro,Buk Gu, Daegu 41566, South Korea | Lee, Sangwook/O-9166-2015; Nguyen, Tien-Anh/AAF-7046-2019; Xuan, Hien/AAF-7020-2019; Hung, pham/ABF-3792-2021 | 57194216208; 57209732166; 57209165823; 57212475700; 54408588700; 57338060200; 57203597324; 57204923460; 7004298542 | ywheo@knu.ac.kr; | MATERIALS RESEARCH BULLETIN | MATER RES BULL | 0025-5408 | 1873-4227 | 147 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2022 | 5.4 | 31.2 | 1.08 | 2025-06-25 | 13 | 13 | Cs2SnI6; Halide perovskite; CVD method; NO2; gas sensors | LEAD HALIDE PEROVSKITES; ROOM-TEMPERATURE; GAS SENSOR; PERFORMANCE; DEPOSITION; WATER | Cs<sub>2</sub>SnI<sub>6</sub>; CVD method; gas sensors; Halide perovskite; NO<sub>2</sub> | Cesium iodide; Chemical sensors; Chemical vapor deposition; Film growth; Gases; Glass; Nitrogen oxides; Perovskite; Substrates; Thin films; Tin compounds; Average diameter; Chemical vapor deposition methods; Chemical vapour deposition; Gas-sensors; Glass substrates; Halide perovskites; Sensing property; Synthesised; Thin-films; Two-step process; Gas detectors | English | 2022 | 2022-03 | 10.1016/j.materresbull.2021.111628 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Inhibition of BRD4 Promotes Pexophagy by Increasing ROS and ATM Activation | Although autophagy regulates the quality and quantity of cellular compartments, the regulatory mechanisms underlying peroxisomal autophagy (pexophagy) remain largely unknown. In this study, we identified several BRD4 inhibitors, including molibresib, a novel pexophagy inducer, via chemical library screening. Treatment with molibresib promotes loss of peroxisomes selectively, but not mitochondria, ER, or Golgi apparatus in HeLa cells. Consistently, depletion of BRD4 expression also induced pexophagy in RPE cells. In addition, the inhibition of BRD4 by molibresib increased autophagic degradation of peroxisome ATG7-dependency. We further found that molibresib produced reactive oxygen species (ROS), which potentiates ATM activation. Inhibition of ROS or ATM suppressed the loss of peroxisomes in molibresib-treated cells. Taken together, our data suggest that inhibition of BRD4 promotes pexophagy by increasing ROS and ATM activation. | Kim, Yong Hwan; Jo, Doo Sin; Park, Na Yeon; Bae, Ji-Eun; Kim, Joon Bum; Lee, Ha Jung; Kim, So Hyun; Kim, Seong Hyun; Lee, Sunwoo; Son, Mikyung; Park, Kyuhee; Jeong, Kwiwan; Yeom, Eunbyul; Cho, Dong-Hyung | Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41566, South Korea; Orgasis Corp, Suwon 16229, Gyeonggi Do, South Korea; Gyeonggido Business & Sci Accelerator, Bioctr, Suwon 16229, Gyeonggi Do, South Korea | KIM, SUNG MIN/U-5269-2017; Choi, Hye Rin/JDV-9065-2023; Kim, Joon/ADP-8066-2022 | 57204676401; 56335489800; 57190609826; 57190605352; 57190611030; 57221856423; 57253406800; 57253406700; 57897523800; 57880088000; 57194598552; 57197993212; 56058004100; 35093684400 | dhcho@knu.ac.kr; | CELLS | CELLS-BASEL | 2073-4409 | 11 | 18 | SCIE | CELL BIOLOGY | 2022 | 6 | 31.2 | 0.63 | 2025-06-25 | 9 | 10 | pexophagy; peroxisome; molibresib; BRD4; ROS | AUTOPHAGY; PEROXISOME | BRD4; molibresib; peroxisome; pexophagy; ROS | Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; HeLa Cells; Humans; Macroautophagy; Nuclear Proteins; Peroxisomes; Reactive Oxygen Species; Transcription Factors; ATM protein; bafilomycin; bromodomain inhibitor; molibresib; reactive oxygen metabolite; ATM protein; ATM protein, human; BRD4 protein, human; cell cycle protein; nuclear protein; reactive oxygen metabolite; transcription factor; apoptosis; Article; autophagy (cellular); cell viability; confocal microscopy; human; pexophagy; ubiquitination; Western blotting; HeLa cell line; macroautophagy; metabolism; peroxisome | English | 2022 | 2022-09 | 10.3390/cells11182839 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
페이지 이동: