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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Changes in the Bronchial Cuff Pressure of Left-Sided Double-Lumen Endotracheal Tube by Lateral Positioning: A Prospective Observational Study | Proper bronchial cuff pressure (BCP) is important when using a double-lumen endotracheal tube (DLT), especially in thoracic surgery. As positional change during endotracheal tube placement could alter cuff pressure, we aim to evaluate the change in BCP of DLT from the supine to the lateral decubitus position during thoracic surgery. A total of 69 patients aged 18-70 years who underwent elective lung surgery were recruited. BCP was measured at a series of time points in the supine and lateral decubitus positions after confirming the DLT placement. The primary outcome was change in the initial established BCP (BCPi), which is the maximum pressure at which the BCP did not exceed 40 cmH(2)O without air leak in the supine position, after lateral decubitus positioning. As the primary outcome, the BCPi increased from 25.4 +/- 9.0 cmH(2)O in the supine position to 29.1 +/- 12.2 cmH(2)O in the lateral decubitus position (p < 0.001). Out of the 69 participants, 43 and 26 patients underwent surgery in the left-lateral decubitus position (LLD group) and the right-lateral decubitus position (RLD group) respectively. In the LLD group, the BCPi increased significantly (p < 0.001) after lateral positioning and the beginning of surgery and the difference value, increment BCPi, from supine to lateral position was significantly higher in the LLD group than in the RLD group (p = 0.034). Positional change from supine to lateral decubitus could increase the BCPi of DLT and the increase was significantly greater in LLD that in RLD. | Kim, Jong-Hae; Kim, Eugene; Kim, In-Young; Choi, Eun-Joo; Byun, Sung-Hye | Daegu Catholic Univ, Sch Med, Dept Anesthesiol & Pain Med, 33 Duryugongwon Ro 17 Gil, Daegu 42472, South Korea; Hanyang Univ, Coll Med, Med Ctr, Dept Anesthesiol & Pain Med, 222-1 Wangsimni Ro, Seoul 04763, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Anesthesiol & Pain Med, 807 Hoguk Ro, Daegu 41404, South Korea | Kim, JongHae/HGC-1554-2022; Byun, Sung Hye/AEK-1234-2022 | 57865562800; 57203552434; 57208058100; 58039921000; 56921446300 | usmed12@gmail.com;tomomie@hanmail.net;kiy215@naver.com;sthgood9@naver.com;stone0311@naver.com; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 10 | 8 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 4.964 | 31.7 | 0.57 | 2025-07-30 | 5 | 5 | double-lumen tube; lateral position; cuff; pressure; thoracic surgery | Cuff; Double-lumen tube; Lateral position; Pressure; Thoracic surgery | propofol; remifentanil; rocuronium; adult; aged; anesthesia induction; anesthesia level; Article; bispectral index; clinical outcome; controlled study; data analysis software; elective surgery; endotracheal intubation; female; fiberoptic bronchoscopy; human; lateral decubitus position; lung surgery; major clinical study; male; observational study; patient positioning; pressure; prospective study; supine position; video assisted thoracoscopic surgery | English | 2021 | 2021-04 | 10.3390/jcm10081590 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Characteristics, Location, and Clinical Outcomes of Gastrointestinal Bleeding in Patients Taking New Oral Anticoagulants Compared to Vitamin K Antagonists | New oral anticoagulants (NOACs) are commonly used in clinical practice as alternatives to vitamin K antagonists (VKA). However, the etiology, clinical course, and risk of gastrointestinal (GI) bleeding remain unclear. We aimed to evaluate the clinical characteristics and location of acute GI bleeding associated with NOACs and its severity and outcomes compared to VKA. This retrospective multicenter study included 381 subjects on anticoagulants who underwent appropriate diagnostic examination due to GI bleeding. Regarding the characteristics of acute GI bleeding, the proportion of vascular lesions was significantly lower in the NOACs group than that in the VKA group. Small bowel bleeding occurred less commonly in the NOACs group, but the difference did not reach statistical significance. Regarding severity and clinical outcomes, patients on NOACs received significantly smaller volumes of transfused blood products and had shorter ICU stays than those on VKA. Moreover, the need for surgery and the risk of rebleeding in the NOACs group were significantly lower than those in the VKA group. Patients on NOACs have better clinical outcomes in terms of severity of acute GI bleeding or rebleeding than patients on VKA. Patients on NOACs demonstrate different characteristics and location of acute GI bleeding than those on VKA. | Choe, A. Reum; Moon, Chang Mo; Tae, Chung Hyun; Chun, Jaeyoung; Bang, Ki Bae; Lee, Yoo Jin; Lee, Hyun Seok; Jung, Yunho; Park, Sung Chul; Koo, Hoon Sup | Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul 07985, South Korea; Ewha Womans Univ, Coll Med, Inflammat Canc Microenvironm Res Ctr, Seoul 07804, South Korea; Seoul Natl Univ, Liver Res Inst, Dept Internal Med, Coll Med, Seoul 03080, South Korea; Yonsei Univ, Gangnam Severance Hosp, Dept Internal Med, Coll Med, Seoul 06273, South Korea; Dankook Univ, Dept Internal Med, Coll Med, Cheonan 31116, South Korea; Keimyung Univ, Dept Internal Med, Sch Med, Daegu 42601, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41404, South Korea; Soonchunhyang Univ, Dept Internal Med, Coll Med, Cheonan 31151, South Korea; Kangwon Natl Univ, Dept Internal Med, Sch Med, Chunchon 24289, South Korea; Konyang Univ, Dept Internal Med, Coll Med, Daejeon 35365, South Korea | Park, Sung Chul/AGO-1773-2022; Lee, Jong-Seok/J-5603-2012; Kim, Hyung-Ho/HZM-2707-2023; Chun, Jaeyoung/G-2921-2015 | 57190020909; 8131765500; 35211966400; 55936772800; 57204337211; 55531365900; 36647886100; 54789008200; 39161700000; 36523211900 | prems0121@naver.com;mooncm27@ewha.ac.kr;jhtae@ewha.ac.kr;J40479@gmail.com;kibaebang@gmail.com;doctorlyj@dsmc.or.kr;lhsworld@nate.com;yoonho7575@naver.com;schlp@hanmail.net;koo7574@naver.com; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 10 | 12 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 4.964 | 31.7 | 0.11 | 2025-07-30 | 2 | 2 | gastrointestinal bleeding; new oral anticoagulants; vitamin K antagonist; rebleeding | VENOUS THROMBOEMBOLISM; ATRIAL-FIBRILLATION; MANAGEMENT; WARFARIN; RISK; RIVAROXABAN; STRATEGIES; HEMORRHAGE; GUIDELINE; EFFICACY | Gastrointestinal bleeding; New oral anticoagulants; Rebleeding; Vitamin K antagonist | acetylsalicylic acid; antivitamin K; apixaban; clopidogrel; dabigatran; edoxaban; histamine H2 receptor antagonist; nonsteroid antiinflammatory agent; proton pump inhibitor; rivaroxaban; steroid; warfarin; abdominal radiography; acute disease; adult; aged; angiodysplasia; Article; atrial fibrillation; benign gastric ulcer; capsule endoscopy; clinical feature; clinical outcome; cohort analysis; colitis; colon; colon cancer; colon polyp; colon ulcer; colonoscopy; comorbidity; comparative study; computer assisted tomography; deep vein thrombosis; demography; Dieulafoy disease; digestive system disease assessment; disease severity; duodenal angiodysplasia; duodenal dieulafoy lesion; duodenitis; duodenum; duodenum disease; duodenum ulcer; erythrocyte transfusion; esophageal angiodysplasia; esophagogastroduodenoscopy; esophagus; esophagus varices; female; gastric angiodysplasia; gastric dieulafoy; gastric varix; gastrointestinal hemorrhage; HAS BLED score; heart atrium flutter; hematemesis; hemorrhoid; human; in-hospital mortality; infectious colitis; inflammation; inflammatory bowel disease; intensive care unit; intestine diverticulosis; intestine endoscopy; ischemic colitis; length of stay; lung embolism; major clinical study; male; Mallory Weiss syndrome; melena; multicenter study; neoplasm; pelvis radiography; postoperative hemorrhage; pseudomembranous colitis; rectal ulcer; rectum disease; rectum hemorrhage; rectum ulcer; retrospective study; risk; sigmoidoscopy; small bowel enteroscopy; small intestine; small intestine hemorrhage; small intestine tumor; South Korea; stomach; stomach antrum vascular ectasia; stomach cancer; stomach disease; stomach erosion; stomach ulcer; tertiary care center; vascular lesion | English | 2021 | 2021-06 | 10.3390/jcm10122693 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Clinical Analysis of Persistent Subretinal Fluid after Pars Plana Vitrectomy in Macula with Diabetic Tractional Retinal Detachment | (1) Background: We analyzed the duration of persistent subretinal fluid (PSF) and the contributing factors of PSF after pars plana vitrectomy in patients who had a macula with diabetic tractional retinal detachment (TRD). (2) Methods: Forty eyes of 40 patients who had pars plana vitrectomy due to a macula with diabetic TRD, between 2014 and 2020, were retrospectively reviewed. The duration of PSF, as well as relevant ocular and systemic factors, was analyzed. (3) Results: The mean duration of PSF was 4.4 +/- 4.7 months. The prevalence of PSF was 75.0% at 1 month, 50.0% at 3 months, 30.0% at 6 months and 10.0% at 12 months after surgery. Blood urea nitrogen, creatinine, and estimated glomerular filtration rate (eGFR) were significantly associated with the duration of PSF in the univariate analysis. In the multivariate analysis, only eGFR was significantly associated with the duration of PSF (beta = -0.089, p = 0.030). (4) Conclusion: PSF may persist for more than 12 months in a macula with diabetic TRD after vitrectomy. Moreover, patients with impaired kidney function tended to have a delayed subretinal fluid absorption. Therefore, careful investigation of preoperative systemic conditions, especially kidney function, should be considered before TRD surgery in diabetic patients. | Kang, Yong-Koo; Shin, Jae-Pil | Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, Daegu 41944, South Korea | KANG, YONG KOO/IVH-8723-2023 | 57204703736; 56517350400 | kykyuri@gmail.com;jps11@hanmail.net; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 10 | 24 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 4.964 | 31.7 | 0.57 | 2025-07-30 | 4 | 5 | estimated glomerular filtration rate; persistent subretinal fluid; proliferative diabetic retinopathy; tractional retinal detachment | SUBFOVEAL FLUID; RETINOPATHY; ASSOCIATION; PHOTOCOAGULATION; ENDOTAMPONADE; SECONDARY; MEMBRANE; SURGERY | Estimated glomerular filtration rate; Persistent subretinal fluid; Proliferative diabetic retinopathy; Tractional retinal detachment | bevacizumab; creatinine; urea; vasculotropin antibody; adult; Article; best corrected visual acuity; clinical article; clinical evaluation; controlled study; creatinine blood level; data analysis software; diabetic patient; disease duration; estimated glomerular filtration rate; female; human; kidney function; male; middle aged; optical coherence tomography; pars plana vitrectomy; prevalence; proliferative diabetic retinopathy; retina macula lutea; retrospective study; subretinal fluid; surgical technique; urea nitrogen blood level | English | 2021 | 2021-12 | 10.3390/jcm10245929 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Contemporary Status of Acute Myocardial Infarction in Korean Patients: Korean Registry of Acute Myocardial Infarction for Regional Cardiocerebrovascular Centers | Background: This study aimed to present the development process and characteristics of the Korean Registry of Acute Myocardial Infarction for Regional Cardiocerebrovascular Centers (KRAMI-RCC). Methods: We developed KRAMI-RCC, a web-based registry for patients with AMI. Patients from 14 RCCs were registered for more than three years from July 2016. It includes an automatic error-checking system, and user training and on-site monitoring are performed to manage data quality. Results: A total of 11,700 AMI patients were registered in KRAMI-RCC over three years (73.9% men). The proportions of patients with ST-elevation and non-ST-elevation myocardial infarction at discharge were 43.4% and 56.6%, respectively. Of the total three-year patients, 5.6% died in the hospital, and 4.4% died 12 months after discharge. The case fatality within 12 months was 9.7%. Pre-hospital care data showed delayed arrival time after onset of symptoms (median 153 min) and low transportation rate by public ambulance (25.2%). Post-hospital care data showed lower participation rate in the second rehabilitation program (16.8%). Conclusions: The recently developed KRAMI-RCC registry has been more focused on pre-hospital and post-hospital data, which will be helpful in understanding the current state of AMI disease management and in making policy decisions to reduce case fatality in Korea. | Kim, Rock Bum; Hwang, Jin Yong; Park, Hyun Woong; Her, Ae-Young; Lee, Jang Hoon; Kim, Moo Hyun; Yoon, Chang Hwan; Cho, Jae Young; Woo, Sung-Il; Kim, Yongcheol; Han, Jae-Young; Choi, Joon Hyouk; Kim, Song Yi; Choi, Si Wan; Jee, Sung Ju; Lee, Sang Yeub; Won, Ki-Bum; Park, Kyeong-Soo; Hyun, Dae Woo | Gyeongsang Natl Univ Hosp, Reg Cardiocerebrovasc Dis Ctr, Jinju 52727, South Korea; Gyeongsang Natl Univ, Dept Internal Med, Sch Med, Jinju 52727, South Korea; Gyeongsang Natl Univ Hosp, Jinju 52727, South Korea; Kangwon Natl Univ, Sch Med, Dept Internal Med, Div Cardiol, Chunchon 24341, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Daegu 41944, South Korea; Dong A Univ Hosp, Dept Cardiol, Busan 49201, South Korea; Seoul Natl Univ, Coll Med, Bundang Hosp, Cardiovasc Ctr, Seongnam 13620, South Korea; Wonkwang Univ Hosp, Dept Cardiovasc Med, Reg Cardiocerebrovasc Ctr, Iksan 54538, South Korea; Inha Univ Hosp, Dept Internal Med, Div Cardiol, Incheon 22332, South Korea; Chonnam Natl Univ Hosp, Div Cardiol, Gwangju 61469, South Korea; Chonnam Natl Univ, Med Sch & Hosp, Dept Rehabil Med, Gwangju 61469, South Korea; Jeju Natl Univ, Jeju Natl Univ Hosp, Sch Med, Div Cardiol,Dept Internal Med, Jeju 63241, South Korea; Chungnam Natl Univ Hosp, Dept Cardiol, Daejeon 35015, South Korea; Chungnam Natl Univ Hosp, Dept Rehabil Med, Daejeon 35015, South Korea; Chungbuk Natl Univ, Dept Internal Med, Coll Med, Cheongju 28644, South Korea; Univ Ulsan, Coll Med, Div Cardiol, Ulsan Univ Hosp, Ulsan 44033, South Korea; Mokpo Jung Ang Hosp, Reg Cardiocerebrovasc Dis Ctr, Mokpo 58615, South Korea; Andong Gen Hosp, Dept Internal Med, Andong 36743, South Korea | ; Yoon, Changhwan/MXM-0567-2025; Cho, Young-Seok/J-5670-2012; Han, Jae-Young/AAV-1100-2021; Kim, Song-Yi/JAC-5358-2023; Cho, Jae/AAW-7137-2020; Lee, Sang Yeub/AEQ-6658-2022; Jeong, Young-Hoon/F-3476-2015 | 35214909600; 55892914700; 7601564986; 34968030500; 54581258000; 55686265600; 7202882965; 55936313600; 55628587057; 57192112249; 15765035600; 56459207600; 35740671300; 57208291768; 56487143900; 35187345000; 55257125600; 9942929500; 55666084700 | krb747@gmail.com;jyhwang@gnu.ac.kr;chunjium@hanmail.net;hermartha@hanmail.net;ljhmh75@knu.ac.kr;kimmh@dau.ac.kr;changhwanyoon@snubh.org;librato46@gmail.com;siwoo@inha.ac.kr;Dr.YongcheolKim@gmail.com;white--fish@hanmail.net;valgom@naver.com;ttoromom@jejunu.ac.kr;siwanc@cnu.ac.kr;drjeesungju@hamail.net;louisahj@gmail.com;kbwon@uuh.ulsan.kr;kspark386@gmail.com;daewoohyun@naver.com; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 10 | 3 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 4.964 | 31.7 | 1.15 | 2025-07-30 | 11 | 12 | acute myocardial infarction; case fatality; registry | MULTICENTER COHORT; HOSPITALS; MORTALITY; PROJECT; DISEASE | Acute myocardial infarction; Case fatality; Registry | acetylsalicylic acid; angiotensin receptor antagonist; anticoagulant agent; antidiabetic agent; beta adrenergic receptor blocking agent; calcium channel blocking agent; cilostazol; clopidogrel; dipeptidyl carboxypeptidase inhibitor; ezetimibe; fibric acid derivative; hydroxymethylglutaryl coenzyme A reductase inhibitor; insulin; prasugrel; ticagrelor; warfarin; acute heart infarction; adult; aged; alcohol consumption; Article; atrial fibrillation; case fatality rate; cerebrovascular accident; controlled study; demography; diabetes mellitus; emergency care; female; heart arrest; heart failure; hospital mortality; human; hypertension; Korean (people); major clinical study; male; middle aged; non ST segment elevation myocardial infarction; patient education; percutaneous coronary intervention; pilot study; register; risk factor; secondary prevention; shock; smoking; smoking cessation; ST segment elevation myocardial infarction | English | 2021 | 2021-02 | 10.3390/jcm10030498 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Current Status of Cardiac Rehabilitation in the Regional Cardiocerebrovascular Centers in Korea | Regional Cardiocerebrovascular Centers (RCCs)-a Korean government initiative-seek to reduce medical gaps across regions, and their cardiac rehabilitation (CR) programs are expected to model post-acute care for the Korean CR program. Accordingly, this study aimed to evaluate the current status of CR programs in the RCCs. We distributed surveys on the CR condition, activity, and barriers to 12 RCCs in different provinces. The results revealed significant gaps in the annual number of acute myocardial infarction admissions, and CR candidates, capacity, and density across the 12 RCCs. The CR capacity (50-500) and density (0.42-7.36) indicated particularly large gaps. Twelve RCCs had the necessary facilities, equipment and personnel for CR assessments and management, with high CR referral (97%) and patient education (78%) rates. However, the inpatient CR exercise training (56%) participation rate was inadequate, with much lower enrollment (47%) and adherence (17%) rates to the outpatient CR program and large differences across centers. Therefore, this study's results will provide the evidence required to establish special national health strategies to overcome the CR barriers of patient, doctor/hospital, and policy factors for activating Korean CR programs. | Kim, Chul; Sung, Jidong; Han, Jae-Young; Jee, Sungju; Lee, Jang Woo; Lee, Jong Hwa; Kim, Won-Seok; Bang, Heui Je; Baek, Sora; Joa, Kyung-Lim; Kim, Ae Ryoung; Lee, So Young; Kim, Jihee; Kim, Chung Reen; Kwon, Oh Pum | Inje Univ, Sanggye Paik Hosp, Dept Rehabil Med, Seoul 01757, South Korea; Sungkyunkwan Univ, Sch Med, Dept Med, Div Cardiol, Seoul 06351, South Korea; Chonnam Natl Univ Med Sch & Hosp, Dept Phys Med & Rehabil, Gwangju 61469, South Korea; Chungnam Natl Univ, Coll Med, Dept Rehabil Med, Daejeon 35015, South Korea; Natl Hlth Insurance Serv Ilsan Hosp, Dept Phys Med & Rehabil, Goyang 10444, South Korea; Dong A Univ, Coll Med, Dept Phys Med & Rehabil, Busan 49201, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Rehabil Med, Seongnam 13620, South Korea; Chungbuk Natl Univ Hosp, Dept Rehabil Med, Cheongju 28644, South Korea; Kangwon Natl Univ, Sch Med, Dept Rehabil Med, Chunchon 24289, South Korea; Inha Univ Hosp, Dept Rehabil Med, Incheon 22332, South Korea; Kyungpook Natl Univ, Sch Med, Dept Rehabil Med, Daegu 41944, South Korea; Jeju Natl Univ, Sch Med, Dept Rehabil Med, Jeju 63241, South Korea; Wonkwang Univ, Sch Med, Dept Rehabil Med, Iksan 54538, South Korea; Ulsan Univ, Coll Med, Dept Rehabil Med, Ulsan 44033, South Korea | ; Han, Jae-Young/AAV-1100-2021; Lee, Jaewon/N-9064-2013; , 김원석/AAJ-2334-2020; Joa, Kyung-Lim/ABB-3860-2020 | 55936526100; 57221027209; 15765035600; 56487143900; 55999572900; 55690046100; 57028735900; 55246577800; 55875523200; 55245910100; 57196257330; 57202327370; 55822889900; 35848509700; 55822295300 | josephck@naver.com;jidong.sung@gmail.com;rmhanjy@daum.net;drjeesungju@cnuh.co;medipia@gmail.com;jhlee08@dau.ac.kr;Wondol77@gmail.com;bang@chungbuk.ac.kr;sora.baek@kangwon.ac.kr;drjoakl@gmail.com;Ryoung20@hanmail.net;bluelsy900@hanmail.net;gold82mouse@hanmail.net;crkim@uuh.ulsan.kr;Pum78@naver.com; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 10 | 21 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 4.964 | 31.7 | 2.29 | 2025-07-30 | 21 | 22 | barriers; cardiac rehabilitation; hospital-based; participation rate | ACUTE MYOCARDIAL-INFARCTION; CARDIOVASCULAR-DISEASE; CLINICAL-PERFORMANCE; PREVENTION; MORTALITY; BARRIERS | Barriers; Cardiac rehabilitation; Hospital‐based; Participation rate | acute heart infarction; advanced cardiac life support; Article; cardiac rehabilitation in depth questionnaire; cardiac rehabilitationl general questionnaire; electrocardiography; health care delivery; health care policy; health survey; heart rehabilitation; high risk patient; human; mitral valve surgery; multicenter study; patient education; patient referral; percutaneous coronary intervention; practice guideline; questionnaire; regional cardiocerebrovascular center; South Korea; telemetry; tertiary care center | English | 2021 | 2021-11 | 10.3390/jcm10215079 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Early Improvements in Disease Activity Indices Predict Long-Term Clinical Remission Suggested by the Treat-to-Target Strategy in Patients with Ankylosing Spondylitis Receiving TNF-α Inhibitor Treatment | This study evaluated the possibility of clinical remission suggested by the treat-to-target strategy and identified predictors of clinical remission in 139 patients with ankylosing spondylitis (AS) receiving tumor necrosis factor-alpha inhibitors (TNFi). Clinical remission criteria selected were AS Disease Activity Score Inactive Disease (ASDAS-ID) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) < 2 with normal C-reactive protein (CRP) levels (BASDAI-CRP). The longitudinal relationship between clinical parameters and clinical remission was assessed using generalized estimating equations (GEEs). Responders to ASDAS-ID and BASDAI-CRP increased from 32.4% to 68.9% and from 39.9% to 75.2% at months 3 and 33, respectively. Responders to ASDAS-ID and BASDAI-CRP almost overlapped. In the univariable GEE model, age and 3-month improvement in BASDAI, ASDAS-CRP, physician and patient global assessments, and spinal pain predicted clinical remission achievement, while the presence of syndesmophytes predicted ASDAS-CRP achievement, and normalized CRP at 3 months was associated with BASDAI-CRP achievement. Multivariable GEE analysis revealed age (odds ratio (OR): 0.67; 95% confidence interval (CI), 0.49-0.93) and 3-month BASDAI improvement (OR: 1.70; CI, 1.19-2.41) as independent predictors of ASDAS-ID achievement and age (OR: 0.69; CI, 0.54-0.89), 3-month BASDAI improvement (OR: 2.00; CI, 1.45-2.76), and normalized CRP at 3 months (OR: 3.72; CI, 1.39-9.95) as independent predictors of BASDAI-CRP achievement. | Nam, Eon Jeong; Lee, Won Kee | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Rheumatol, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Med Res Collaborat Ctr, Daegu 41404, South Korea | 7005824293; 22953484700 | ejnam@knu.ac.kr;wonlee@knu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 10 | 18 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 4.964 | 31.7 | 0.46 | 2025-07-30 | 4 | 4 | ankylosing spondylitis; TNF-alpha inhibitor; clinical remission; ASDAS-ID; BASDAI-CRP | AXIAL SPONDYLOARTHRITIS; LONGITUDINAL DATA; RECOMMENDATIONS | Ankylosing spondylitis; ASDAS-ID; BASDAI-CRP; Clinical remission; TNF-α inhibitor | adalimumab; antirheumatic agent; C reactive protein; etanercept; golimumab; HLA B27 antigen; infliximab; nonsteroid antiinflammatory agent; tumor necrosis factor inhibitor; adult; ankylosing spondylitis; Ankylosing Spondylitis Disease Activity Score; Ankylosing Spondylitis Disease Activity Score Inactive Disease; Article; Bath ankylosing spondylitis disease activity index; Bath ankylosing spondylitis functional index; clinical feature; controlled study; disease duration; drug withdrawal; female; human; major clinical study; male; observational study; prediction; prognosis; remission; retrospective study; spinal pain; treatment response; unspecified side effect; uveitis | English | 2021 | 2021-09 | 10.3390/jcm10184279 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | GDF-15 Predicts In-Hospital Mortality of Critically Ill Patients with Acute Kidney Injury Requiring Continuous Renal Replacement Therapy: A Multicenter Prospective Study | Growth differentiation factor-15 (GDF-15) is a stress-responsive cytokine. This study evaluated the association between GDF-15 and in-hospital mortality among patients with severe acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). Among the multicenter prospective CRRT cohort between 2017 and 2019, 66 patients whose blood sample was available were analyzed. Patients were divided into three groups according to the GDF-15 concentrations. The median GDF-15 level was 7865.5 pg/mL (496.9 pg/mL in the healthy control patients). Baseline characteristics were not different among tertile groups except the severity scores and serum lactate level, which were higher in the third tertile. After adjusting for confounding factors, the patients with higher GDF-15 had significantly increased risk of mortality (second tertile: adjusted hazards ratio [aHR], 3.67; 95% confidence interval [CI], 1.05-12.76; p = 0.041; third tertile: aHR, 6.81; 95% CI, 1.98-23.44; p = 0.002). Furthermore, GDF-15 predicted in-hospital mortality (area under the curve, 0.710; 95% CI, 0.585-0.815) better than APACHE II and SOFA scores. Serum GDF-15 concentration was elevated in AKI patients requiring CRRT, higher in more severe patients. GDF-15 is a better independent predictor for in-hospital mortality of critically ill AKI patients than the traditional risk scoring system such as APACHE II and SOFA scores. | Lim, Jeong-Hoon; Jeon, Yena; Ahn, Ji-Sun; Kim, Sejoong; Kim, Dong Ki; Lee, Jung Pyo; Ryu, Dong-Ryeol; Seong, Eun Young; Ahn, Shin Young; Ha Baek, Seon; Jung, Hee-Yeon; Choi, Ji-Young; Park, Sun-Hee; Kim, Chan-Duck; Kim, Yong-Lim; Cho, Jang-Hee | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med,Div Nephrol, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu 41566, South Korea; Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam Si 13620, South Korea; Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul 08826, South Korea; Seoul Natl Univ, Dept Internal Med, Boramae Med Ctr, Seoul 07061, South Korea; Ewha Womans Univ, Sch Med, Dept Internal Med, Seoul 07804, South Korea; Pusan Natl Univ, Div Nephrol, Sch Med, Busan 50612, South Korea; Korea Univ, Dept Internal Med, Coll Med, Seoul 02841, South Korea; Hallym Univ, Dept Internal Med, Dongtan Sacred Heart Hosp, Hwaseong 18450, South Korea | ; Kim, Dong Ki/J-5389-2012; Lee, Jun-Young/N-5963-2019; Kim, Sejoong/J-5356-2015; Kim, Yong-Lim/AGK-3172-2022; Cho, Jang-hee/ABD-3534-2020; Park, Sun-Hee/LMN-0033-2024; Lim, Jeong-Hoon/ABE-6003-2020 | 55360244300; 57209909350; 57191631694; 36068539400; 23479259100; 56028990400; 56669926200; 15726817400; 55313081300; 54957359000; 57196396467; 7501393222; 7501831741; 8558530700; 55633533600; 7403536291 | jh-lim@knu.ac.kr;yeahnah@naver.com;ggumsuni@daum.net;sejoong@snubh.org;dkkim73@gmail.com;nephrolee@gmail.com;dr6302@gmail.com;sey-0220@hanmail.net;ahnshinyoung712@gmail.com;haya2001@daum.net;hy-jung@knu.ac.kr;jyss1002@hanmail.net;sh-park@knu.ac.kr;drcdkim@knu.ac.kr;ylkim@knu.ac.kr;jh-cho@knu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 10 | 16 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 4.964 | 31.7 | 0.57 | 2025-07-30 | 6 | 7 | acute kidney injury; in-hospital mortality; continuous renal replacement therapy; growth differentiation factor-15 | GROWTH-DIFFERENTIATION FACTOR-15; BETA SUPERFAMILY MEMBER; INHIBITORY CYTOKINE-1 MIC-1/GDF15; FAILURE ASSESSMENT SCORE; ORGAN FAILURE; RISK STRATIFICATION; HEART-FAILURE; EPIDEMIOLOGY; BIOMARKERS; SEPSIS | Acute kidney injury; Continuous renal replacement therapy; Growth differentiation factor-15; In-hospital mortality | C reactive protein; creatinine; growth differentiation factor 15; hypertensive factor; lactic acid; acute kidney failure; aged; APACHE; Article; artificial ventilation; Charlson Comorbidity Index; cohort analysis; continuous renal replacement therapy; controlled study; creatinine blood level; critically ill patient; disease severity; enzyme immunoassay; enzyme linked immunosorbent assay; estimated glomerular filtration rate; female; human; human tissue; in-hospital mortality; lactate blood level; major clinical study; male; mean arterial pressure; multicenter study; prospective study; protein blood level; Sequential Organ Failure Assessment Score; survival | English | 2021 | 2021-08 | 10.3390/jcm10163660 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Influence of Estimated Glomerular Filtration Rate on Clinical Outcomes in Patients with Acute Ischemic Stroke Not Receiving Reperfusion Therapies | Background: We aimed to determine whether estimated glomerular filtration rate (eGFR) is an independent predictor of clinical outcomes in patients with acute ischemic stroke not treated with reperfusion therapy. Methods: A total of 1420 patients with acute ischemic stroke from a hospital-based stroke registry were included in this study. Patients managed with intravenous thrombolysis or endovascular reperfusion therapy were excluded. The included patients were categorized into five groups according to eGFR, as follows: >= 90, 60-89, 45-59, 30-44, and < 30 mL/min/1.73 m(2). The effects of eGFR on functional outcome at discharge, in-hospital mortality, neurologic deterioration, and hemorrhagic transformation were evaluated using logistic regression analyses. Results: In univariable logistic regression analysis, reduced eGFR was associated with poor functional outcome at discharge (p < 0.001) and in-hospital mortality (p = 0.001), but not with neurologic deterioration and hemorrhagic transformation. However, no significant associations were observed between eGFR and any clinical outcomes in multivariable analysis after adjusting for clinical and laboratory variables. Conclusions: Reduced eGFR was associated with poor functional outcomes at discharge and in-hospital mortality but was not an independent predictor of short-term clinical outcomes in patients with acute ischemic stroke who did not undergo reperfusion therapy. | Eun, Mi-Yeon; Park, Jin-Woo; Cho, Bang-Hoon; Cho, Kyung-Hee; Yu, Sungwook | Kyungpook Natl Univ, Dept Neurol, Chilgok Hosp, Daegu 41404, South Korea; Korea Univ, Coll Med, Dept Neurol, Anam Hosp, Seoul 02841, South Korea | Park, Jinwoo/AAD-1328-2022; Eun, Mi-Yeon/AAV-2877-2021 | 36463396500; 57221409234; 55171752400; 57111193500; 56144716300 | eunmiyn@gmail.com;parkzinu@korea.ac.kr;fevernakchal@naver.com;kh.cho.neuro@gmail.com;song4yu@korea.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 10 | 20 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 4.964 | 31.7 | 0 | 2025-07-30 | 0 | 0 | estimated glomerular filtration rate; chronic kidney disease; ischemic stroke; clinical outcome | CHRONIC KIDNEY-DISEASE; PRACTICE GUIDELINES; RENAL-FUNCTION; ASSOCIATION; CLASSIFICATION; EQUATION | Chronic kidney disease; Clinical outcome; Estimated glomerular filtration rate; Ischemic stroke | C reactive protein; hemoglobin; high density lipoprotein cholesterol; homocysteine; uric acid; acute ischemic stroke; adult; age distribution; aged; Article; atrial fibrillation; blood clot lysis; cardiovascular risk factor; chronic kidney failure; clinical outcome; controlled study; deterioration; estimated glomerular filtration rate; female; hemoglobin blood level; high density lipoprotein cholesterol level; hospital discharge; human; in-hospital mortality; leukocyte count; major clinical study; male; mortality rate; National Institutes of Health Stroke Scale; observational study; outcome assessment; protein blood level; reperfusion; retrospective study; risk assessment; stroke patient; uric acid blood level | English | 2021 | 2021-10 | 10.3390/jcm10204719 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Perirenal Adipose Tissue from Healthy Donor: Characteristics and Promise as Potential Therapeutic Cell Source | Perirenal adipose tissue, one of the fat masses surrounding the kidneys, can be obtained from healthy donors during a kidney transplant. Perirenal adipose tissue has only ever been known as a connective tissue to protect the kidneys and renal blood vessels from external physical stimulation. Yet, recently, as adipose tissue has begun to be considered an endocrine organ, and perirenal adipose tissue is now regarded to have a direct effect on metabolic diseases. The characteristics of perirenal adipose tissue from a healthy donor are that: (1) There are a large number of brown adipose cells (70-80% of the total), (2) Most of the brown adipose cells are inactive in the resting cell cycle, (3) Activating factors are constant low-temperature exposure, hormones, metastasis factors, and environmental factors, (4) Anatomically, a large number of brown adipose cells are distributed close to the adrenal glands, (5) Beige cells, produced by converting white adipocytes to brown-like adipocytes, are highly active, (6) Activated cells secrete BATokines, and (7) Energy consumption efficiency is high. Despite these advantages, all of the perirenal adipose tissue from a healthy donor is incinerated as medical waste. With a view to its use, this review discusses the brown adipocytes and beige cells in perirenal adipose tissue from a healthy donor, and proposes opportunities for their clinical application. | Lee, Eun Hye; Chun, So Young; Lee, Jun Nyung; Chung, Jae-Wook; Yoon, Bo Hyun; Kim, Hyun Tae; Kwon, Tae Gyun; Ha, Yun-Sok; Kim, Bum Soo | Kyungpook Natl Univ, Joint Inst Regenerat Med, Daegu 41405, South Korea; Kyungpook Natl Univ Hosp, Biomed Res Inst, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu 41566, South Korea | ; Lee, Yun-Soo/AAA-7364-2022; Kim, Soo-Yeon/ADR-9663-2022 | 57189661699; 8688166900; 16301364600; 35204798500; 57218931150; 55739531300; 15073765400; 35487226400; 57202817150 | eun90hye@gmail.com;soyachun99@naver.com;ljnlover@gmail.com;jeus119@hanmail.net;bobo1904@naver.com;urologistk@knu.ac.kr;tgkwon@knu.ac.kr;yunsokha@gmail.com;dock97@hanmail.net; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 10 | 21 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 4.964 | 31.7 | 0.2 | 2025-07-30 | 6 | 7 | perirenal; adipose tissue; healthy donor; brown adipocyte; beige cell | UNCOUPLING PROTEIN-1 UCP1; BROWN-FAT; MITOCHONDRIAL-FUNCTION; ENERGY-EXPENDITURE; WHITE FAT; EXPRESSION; ADIPOCYTES; OBESITY; BEIGE; ADIPOGENESIS | Adipose tissue; Beige cell; Brown adipocyte; Healthy donor; Perirenal | hormone; adrenal gland; beige adipocyte; brown adipocyte; brown adipose tissue; cell cycle; cell therapy; cell transformation; energy consumption; environmental factor; human; low temperature; nonhuman; perirenal fat; Review; white adipocyte | English | 2021 | 2021-11 | 10.3390/jcm10215024 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Prognostic Value of LC3B and p62 Expression in Small Intestinal Adenocarcinoma | Autophagy, a mechanism that maintains cellular homeostasis, is involved in tumor cell growth and survival in cancer, and autophagy inhibitors have been tested clinical trials for anticancer therapy. To elucidate the clinical and prognostic implications of autophagy in small intestinal adenocarcinoma (SIAC), we assessed the expression of autophagy markers, LC3B and p62, in 171 surgically resected primary SIACs using automated quantitative analysis. Positive LC3B, p62 nuclear (p62(Nu)), and p62 cytoplasmic (p62(Cy)) expression was observed in 23 (13.5%), 52 (30.4%), and 43 (25.1%) carcinomas, respectively. LC3B+ expression was correlated with undifferentiated carcinoma (p < 0.001) and high histologic grade (p = 0.029). The combined expression of LC3B and p62(Nu) (LC3+/p62(Nu)+) was related to the older age of patients (p = 0.017), undifferentiated carcinoma (p < 0.001), and high grade (p = 0.031). LC3B+ (p = 0.006), p62(Cy)+ (p = 0.041), or p62(Nu)+ (p = 0.006) expression were associated with worse survival. In addition, SIAC patients with either LC3B+/p62(Nu)+ (p = 0.001) or LC3B+/p62(Cy)+ (p = 0.002) expression had shorter survival times. In multivariate analysis, LC3B expression remained an independent prognostic factor (p = 0.025) for overall survival. In conclusion, autophagy may play a role in the tumorigenesis of SIACs, and LC3B and p62 could be used as prognostic biomarkers and potential therapeutic targets for SIACs. | Kim, Jeong-Won; Jun, Sun-Young; Kim, Joon-Mee; Oh, Young-Ha; Yoon, Ghilsuk; Hong, Seung-Mo; Chung, Joon-Yong | Hallym Univ, Kangnam Sacred Heart Hosp, Dept Pathol, Coll Med, Seoul 07441, South Korea; Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Dept Pathol, Seoul 21431, South Korea; Inha Univ, Dept Pathol, Coll Med, Incheon 22332, South Korea; Hanyang Univ, Dept Pathol, Coll Med, Seoul 04763, South Korea; Kyungpook Natl Univ, Dept Pathol, Sch Med, Daegu 41944, South Korea; Univ Ulsan, Asan Med Ctr, Dept Pathol, Coll Med, Seoul 05550, South Korea; NCI, Lab Pathol, Ctr Canc Res, NIH, Bethesda, MD 20892 USA | ; Kim, Han/C-4709-2011; Chung, Joon-Yong/J-9177-2017 | 55145479500; 7103305476; 57554573600; 57246865300; 7103257906; 13307199900; 57195950639 | jwkim@hallym.or.kr;pathssun@gmail.com;jmkpath@inha.ac.kr;yhoh@hanyang.ac.kr;gsyoon@knu.ac.kr;smhong28@gmail.com;chungjo@mail.nih.gov; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 10 | 22 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 4.964 | 31.7 | 0.69 | 2025-07-30 | 5 | 6 | LC3B; p62; prognosis; small intestine; adenocarcinoma | SMALL-BOWEL ADENOCARCINOMA; PROTEIN EXPRESSION; POOR-PROGNOSIS; BIOCHEMICAL METHODS; BECLIN 1; AUTOPHAGY; CANCER; OVEREXPRESSION; PATHOGENESIS; PROGRESSION | Adenocarcinoma; LC3B; P62; Prognosis; Small intestine | autophagy related protein; LC3B protein; sequestosome 1; unclassified drug; adenocarcinoma; adult; aged; anaplastic carcinoma; Article; autoanalysis; autophagy (cellular); cancer prognosis; cancer survival; carcinogenesis; colloid carcinoma; controlled study; data analysis software; digital imaging; female; groups by age; histology; human; human tissue; image analysis; immunohistochemistry; major clinical study; male; median survival time; microsatellite instability; overall survival; protein expression; quantitative analysis; signet ring carcinoma; small intestine cancer; tissue microarray | English | 2021 | 2021-11 | 10.3390/jcm10225398 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | The Association between Peri-Transplant RBC Transfusion and Graft Failure after Kidney Transplantation: A Nationwide Cohort Study | Background: Patients undergoing kidney transplantation (KT) often receive red blood cell (RBC) transfusion during admission for KT which may increase the risk of allosensitization. The association between peri-transplant RBC transfusion and graft survival was evaluated using a nationwide cohort. Methods: This retrospective study analyzed 13,871 patients who underwent KT in Korea between 2007 and 2015. The outcomes were graft failure rate and overall patient survival depending on the amount of RBC transfusion. Results: The overall graft failure rate was 15.5%. Compared to the graft failure rate of 13.5% in the no transfusion group, the graft failure rate was 15.4% in the 1-2 units group (sHR 1.06 (95% CI 0.97-1.17), p = 0.216), 21.4% in the 3-5 units group (sHR 1.39 (1.21-1.61), p < 0.001), and 35.3% in the 6 or more units group (sHR 2.20 (1.70-2.85), p < 0.001). The overall survival rate was 97.5% in the no transfusion group, compared to 95.9% in the 1-2 units group (HR 1.50 (1.22-1.83), p < 0.001), 92.0% in the 3-5 units group (HR 2.43 (1.87-3.15), p < 0.001), and 67.5% in the 6 or more units group (HR 6.81 (5.03-9.22), p < 0.001). Conclusions: Peri-transplant RBC transfusion was independently associated with the increased risk of renal allograft failure and death in KT patients. | Lee, Kyungho; Lee, Seohee; Jang, Eun Jin; Kim, Ga Hee; Yoo, Seokha; Lee, Minkyoo; Jang, Hye Ryoun; Ryu, Ho Geol | Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Sch Med,Div Nephrol, Seoul 06351, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Anesthesiol & Pain Med, Coll Med, Seoul 03080, South Korea; Andong Natl Univ, Dept Informat Stat, Andong 36729, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu 41566, South Korea | Ryu, Ho/J-5463-2012; Yoo, Seokha/H-1638-2018 | 56488757400; 57199185656; 37861741600; 57205094539; 55883558900; 57217588963; 17342455000; 7202277246 | kidney.kh@gmail.com;leesen34@gmail.com;jejstat@gmail.com;genius9105@naver.com;muroki22@gmail.com;2016.real@gmail.com;shinehr@skku.edu;hogeol@gmail.com; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 10 | 16 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 4.964 | 31.7 | 1.15 | 2025-07-30 | 8 | 12 | kidney transplantation; red blood cells; transfusion; graft failure; survival | BLOOD-TRANSFUSIONS; SURVIVAL; SENSITIZATION; IMPROVEMENT; MECHANISMS; REJECTION | Graft failure; Kidney transplantation; Red blood cells; Survival; Transfusion | basiliximab; methylprednisolone; rituximab; thymocyte antibody; acute graft rejection; adult; all cause mortality; allograft; Article; cardiovascular disease; cohort analysis; controlled study; coronary artery disease; deceased donor; delayed graft function; diabetes mellitus; disease severity; erythrocyte transfusion; female; graft failure; graft survival; hospitalization; human; hypertension; ICD-10; intensive care unit; kidney transplantation; Korea; living donor; long term survival; major clinical study; male; middle aged; mortality; operative blood loss; retrospective study; treatment outcome | English | 2021 | 2021-08 | 10.3390/jcm10163750 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | The Effectiveness of Computer-Assisted Cognitive Rehabilitation and the Degree of Recovery in Patients with Traumatic Brain Injury and Stroke | Objectives: To determine the effectiveness of computer-assisted cognitive rehabilitation and compare the patterns of cognitive function recovery occurring in both traumatic brain injury (TBI) and stroke. Methods: A total of 62 patients were finally enrolled, consisting of 30 with TBI and 32 with stroke. The patients received 30 sessions of computer-assisted cognitive rehabilitation (Comcog) five times per week. Each session lasted for 30 min. Before and immediately after cognitive rehabilitation, all patients were evaluated by computerized neuropsychological test (CNT), Mini-Mental State Examination (MMSE), and modified Barthel index (MBI). Results: We analyzed the differences between pre- and post-cognitive rehabilitation in each TBI and stroke group. Significant differences were observed in MMSE, MBI, and some CNT contents, including digit span forward, verbal learning, verbal learning delayed recall, visual span forward, visual span backward, visual learning, trail making test A and B, and intelligence quotient (IQ) in the TBI group (p < 0.05). In the stroke group, in addition to significant differences that appeared in the TBI group, additional significant differences in the digit span backward, visual learning delayed recall, auditory continuous performance test (CPT), visual CPT, and card sorting test. We compared the difference values at pre- and post-cognitive rehabilitation for cognitive recovery between the TBI and stroke groups. All contents, except the digital span forward, visual learning, word-color test, and MMSE, had greater mean values in the stroke group; and thus, statistically significant higher values were observed in the visual span forward and card sorting test (p < 0.05). Conclusion: Most evaluation results showed improvement and the evaluation between the TBI and stroke groups also showed significant differences in cognitive functions in addition to more CNT contents, which significantly change in the stroke group. The stroke group showed a high difference value in most CNT contents. Therefore, those with stroke in the focal brain region tend to have better cognitive function recovery after a computer-assisted cognitive rehabilitation than those with TBI, which could cause diffuse brain damage and post-injury inflammation. | Jung, Hyunwoo; Jeong, Jae-Gyeong; Cheong, Youn-Soo; Nam, Tae-Woo; Kim, Ju-Hyun; Park, Chan-Hee; Park, Eunhee; Jung, Tae-Du | Kyungpook Natl Univ Hosp, Dept Rehabil Med, Daegu 41944, South Korea; Kyungpook Natl Univ Chilgok Hosp, Dept Rehabil Med, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Rehabil Med, Daegu 41944, South Korea | 57222991608; 57222016696; 57040715600; 55438580300; 57208450909; 57299095700; 56107216400; 36622364500 | hwjung_87@naver.com;cloud90524@naver.com;yscheong@gmail.com;n0530@daum.ne;kjoohyun88@gmail.com;chany9090@gmail.com;ehmdpark@naver.com;teeed0522@hanmail.net; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 10 | 24 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 4.964 | 31.7 | 1.38 | 2025-07-30 | 15 | 16 | traumatic brain injury; stroke; computer-assisted cognitive rehabilitation; computerized neuropsychological test | ALZHEIMERS-DISEASE; HEAD-INJURY; IMPAIRMENT; PROTEIN; ADULTS; BETA; CARE | Computer-assisted cognitive rehabilitation; Computerized neuropsychological test; Stroke; Traumatic brain injury | adult; Article; Barthel index; cerebrovascular accident; clinical effectiveness; cognition; cognitive rehabilitation; computer assisted therapy; continuous performance test; controlled study; convalescence; female; human; intelligence quotient; major clinical study; male; medical record review; Mini Mental State Examination; neuropsychological test; recall; retrospective study; stroke patient; traumatic brain injury; verbal learning; Wisconsin Card Sorting Test | English | 2021 | 2021-12 | 10.3390/jcm10245728 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Uterine Cervical Change at Term Examined Using Ultrasound Elastography: A Longitudinal Study | The aim of the study was to investigate if there are changes in elastographic parameters in the cervix at term around the time of delivery and if there are differences in the parameters between women with spontaneous labor and those without labor (labor induction). Nulliparous women at 36 weeks of gestation eligible for vaginal delivery were enrolled. Cervical elastography was performed and cervical length were measured using the E-Cervix(TM) system (WS80A Ultrasound System, Samsung Medison, Seoul, Korea) at each weekly antenatal visit until admission for spontaneous labor or labor induction. E-Cervix parameters of interest included elasticity contrast index (ECI), internal os strain mean level (IOS), external os strain mean level (EOS), IOS/EOS strain mean ratio, strain mean level, and hardness ratio. Regression analysis was performed using days from elastographic measurement at each visit to admission for delivery and the presence or absence of labor against cervical length, and each E-Cervix parameter fitted to a linear model for longitudinal data measured repeatedly. A total of 96 women were included in the analysis, (spontaneous labor, n = 39; labor induction, n = 57). Baseline characteristics were not different between the two groups except for cesarean delivery rate. Cervical length decreased with advancing gestation and was different between the two groups. Most elastographic parameters including ECI, IOS, EOS, strain mean, and hardness ratio were significantly different between the two groups. In addition, ECI, IOS, and strain mean values significantly increased with advancing gestation. Our longitudinal study using ultrasound elastography indicated that E-cervix parameters tended to change linearly at term near the time of admission for delivery and that there were differences in E-Cervix parameters according to the presence or absence of labor. | Park, Hyun Soo; Kwon, Hayan; Kwon, Ja-Young; Jung, Yun Ji; Seol, Hyun-Joo; Seong, Won Joon; Kim, Hyun Mi; Hwang, Han-Sung; Sung, Ji-Hee; Oh, Soo-young | Dongguk Univ, Ilsan Hosp, Dept Obstet & Gynecol, Goyang 10326, South Korea; Yonsei Univ, Yonsei Univ Hlth Syst, Inst Womens Med Life Sci, Div Maternal Fetal Med,Coll Med,Dept Obstet & Gyn, Seoul 03722, South Korea; Kyung Hee Univ Hosp Gangdong, Dept Obstet & Gynecol, Seoul 05278, South Korea; Kyungpook Natl Univ Hosp, Dept Obstet & Gynecol, Daegu 41944, South Korea; Konkuk Univ, Sch Med, Dept Obstet & Gynecol, Med Ctr, Seoul 05030, South Korea; Sungkyunkwan Univ, Sch Med, Dept Obstet & Gynecol, Samsung Med Ctr, Seoul 06351, South Korea | hsparkmd@gmail.com;whitekwonmd@gmail.com;jaykwon@yuhs.ac;ccstty@yuhs.ac;seolhj@khu.ac.kr;wjseong@knu.ac.kr;hyunmik@gmail.com;hwanghs@kuh.ac.kr;obgysung@gmail.com;ohsymd@skku.edu; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 10 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 4.964 | 31.7 | 6 | ultrasonography; elastography; uterine cervix; term pregnancy; parturition | PRETERM DELIVERY; LENGTH; PREGNANCY; RISK | English | 2021 | 2021-01 | 10.3390/jcm10010075 | 바로가기 | 바로가기 | 바로가기 | |||||||||||
| ○ | ○ | Article | A multi-center study of COVID-19 patient prognosis using deep learning-based CT image analysis and electronic health records | Purpose: As of August 30th, there were in total 25.1 million confirmed cases and 845 thousand deaths caused by coronavirus disease of 2019 (COVID-19) worldwide. With overwhelming demands on medical resources, patient stratification based on their risks is essential. In this multi-center study, we built prognosis models to predict severity outcomes, combining patients' electronic health records (EHR), which included vital signs and laboratory data, with deep learning- and CT-based severity prediction. Method: We first developed a CT segmentation network using datasets from multiple institutions worldwide. Two biomarkers were extracted from the CT images: total opacity ratio (TOR) and consolidation ratio (CR). After obtaining TOR and CR, further prognosis analysis was conducted on datasets from INSTITUTE-1, INSTITUTE-2 and INSTITUTE-3. For each data cohort, generalized linear model (GLM) was applied for prognosis prediction. Results: For the deep learning model, the correlation coefficient of the network prediction and manual segmentation was 0.755, 0.919, and 0.824 for the three cohorts, respectively. The AUC (95 % CI) of the final prognosis models was 0.85(0.77,0.92), 0.93(0.87,0.98), and 0.86(0.75,0.94) for INSTITUTE-1, INSTITUTE-2 and INSTITUTE-3 cohorts, respectively. Either TOR or CR exist in all three final prognosis models. Age, white blood cell (WBC), and platelet (PLT) were chosen predictors in two cohorts. Oxygen saturation (SpO2) was a chosen predictor in one cohort. Conclusion: The developed deep learning method can segment lung infection regions. Prognosis results indicated that age, SpO(2), CT biomarkers, PLT, and WBC were the most important prognostic predictors of COVID-19 in our prognosis model. | Gong, Kuang; Wu, Dufan; Arru, Chiara Daniela; Homayounieh, Fatemeh; Neumark, Nir; Guan, Jiahui; Buch, Varun; Kim, Kyungsang; Bizzo, Bernardo Canedo; Ren, Hui; Tak, Won Young; Park, Soo Young; Lee, Yu Rim; Kang, Min Kyu; Park, Jung Gil; Carriero, Alessandro; Saba, Luca; Masjedi, Mahsa; Talari, Hamidreza; Babaei, Rosa; Mobin, Hadi Karimi; Ebrahimian, Shadi; Guo, Ning; Digumarthy, Subba R.; Dayan, Ittai; Kalra, Mannudeep K.; Li, Quanzheng | Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA; MGH & BWH Ctr Clin Data Sci, Boston, MA USA; Nvidia, Boston, MA USA; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Yeungnam Univ, Coll Med, Dept Internal Med, Daegu, South Korea; Azienda Osped Univ Maggiore Carita, Radiol, Novara, Italy; Azienda Osped Univ Policlin Monserrato, Radiol, Monserrato, Italy; Kashan Univ Med Sci, Dept Radiol, Kashan, Iran; Iran Univ Med Sci, Firoozgar Hosp, Dept Radiol, Tehran, Iran | ; CARRIERO, Alessandro/AAL-3790-2020; Kalra, Mannudeep/LXW-4237-2024; Wu, Dufan/AFZ-1956-2022; Ebrahimian, Shadi/AAF-7064-2019; Park, Jung/AAK-5167-2020; Bizzo, Bernardo/AAF-1702-2019; Gong, Kuang/W-6203-2019 | 57146819700; 55286668100; 57217417231; 57204089426; 57212374506; 59817882900; 57200946317; 44861409500; 37050694500; 57214672137; 7004074582; 57191674344; 57194094753; 59142854300; 57216816399; 55168579500; 16234937700; 57201113680; 36624428400; 57219048516; 57219239294; 55313895400; 58714597300; 8512823700; 57219308459; 7007035549; 7405862484 | MKALRA@mgh.harvard.edu;Li.Quanzheng@mgh.harvard.edu; | EUROPEAN JOURNAL OF RADIOLOGY | EUR J RADIOL | 0720-048X | 1872-7727 | 139 | SCIE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2021 | 4.531 | 32.0 | 3.38 | 2025-07-30 | 28 | 33 | COVID-19; Computed tomography; Deep learning; Electronic health records; Prognosis | CHEST CT; PNEUMONIA; THROMBOCYTOPENIA; SEGMENTATION | Computed tomography; COVID-19; Deep learning; Electronic health records; Prognosis | COVID-19; Deep Learning; Electronic Health Records; Humans; Lung; Prognosis; SARS-CoV-2; Tomography, X-Ray Computed; adult; aged; Article; cohort analysis; computer assisted tomography; coronavirus disease 2019; correlation coefficient; deep learning; disease severity; electronic health record; female; human; image analysis; leukocyte count; lung infection; major clinical study; male; multicenter study; outcome assessment; oxygen saturation; platelet count; prognosis; very elderly; vital sign; clinical trial; electronic health record; lung; x-ray computed tomography | English | 2021 | 2021-06 | 10.1016/j.ejrad.2021.109583 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A Study on TiO2 Surface Texturing Effect for the Enhancement of Photocatalytic Reaction in a Total Phosphorous Concentration Measurement System | Powerful sunlight, a high water temperature, and stagnation in the water flow induce eutrophication in rivers and lakes, which destroys the aquatic ecosystem and threatens the downstream water supply systems. Accordingly, it is very important to perform real-time measurements of nutrients that induce algal growth, especially total phosphorus, to preserve and manage the aquatic ecosystem. To conduct quantitative analysis of the total phosphorus in the aquatic ecosystem, it is essential to perform a pretreatment process and quickly separate the phosphorus, combined with organic and inorganic materials, into a phosphate. In this study, the sandblasting process was used for the physical etching of the wafer, and photocatalytic materials were deposited on the surface with various roughness in order to improve the photocatalytic reaction surface and efficiency. The photocatalytic reaction was applied to combine the pretreated sample with the coloring agent for color development, and the absorbance of the colored sample was analyzed quantitatively to compare and evaluate the characteristics, followed by the surface increase in the photocatalytic materials. In addition, the pretreatment and measurement parts were materialized in a single chip to produce a small and light total phosphorus analysis sensor. | Kim, Jae Keon; Kim, Seung Deok; Lee, Jae Yong; Kim, Chang Hee; Lee, Hyeon-Su; Koo, Seong Mo; Lee, YoungJin; Paik, Jong-Hoo; Kim, Da Ye; Kong, Seong Ho | Kyungpook Natl Univ, Dept Sensor & Display Engn, Daegu 41566, South Korea; Medisentech Inc, Tech Bldg B206,80 Daehakro, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Korea Inst Ceram Engn & Technol, Elect Convergence Div, Jinju 52851, South Korea | 57194519849; 57223370762; 57223374818; 57278743200; 57280041800; 57279831400; 59046729600; 7102939628; 57279831500; 57204537951 | shkong@knu.ac.kr; | MICROMACHINES | MICROMACHINES-BASEL | 2072-666X | 12 | 10 | SCIE | CHEMISTRY, ANALYTICAL;INSTRUMENTS & INSTRUMENTATION;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2021 | 3.523 | 32.0 | 0.22 | 2025-07-30 | 3 | 4 | total phosphorus; surface texturing; sandblast; photocatalysis | EUTROPHICATION; MECHANISMS; OXIDATION; NITROGEN; PHASE | Photocatalysis; Sandblast; Surface texturing; Total phosphorus | Eutrophication; Flow of water; Phosphorus; River pollution; Surface reactions; Titanium dioxide; Water supply; Concentration Measurement; Phosphorous concentrations; Photocatalytic materials; Photocatalytic reactions; Sandblast; Surface-texturing; Texturing effect; TiO 2; Total phosphorous; Total phosphorus; Aquatic ecosystems | English | 2021 | 2021-10 | 10.3390/mi12101163 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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