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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Melasolv induces melanosome autophagy to inhibit pigmentation in B16F1 cells | The melanosome is a specialized membrane-bound organelle that is involved in melanin synthesis, storage, and transportation. In contrast to melanosome biogenesis, the processes underlying melanosome degradation remain largely unknown. Autophagy is a process that promotes degradation of intracellular components' cooperative process between autophagosomes and lysosomes, and its role for process of melanosome degradation remains unclear. Here, we assessed the regulation of autophagy and its contributions to depigmentation associated with Melasolv (3,4,5-trimethoxycinnamate thymol ester). B16F1 cells-treated with Melasolv suppressed the alpha-MSH-stimulated increase of melanin content and resulted in the activation of autophagy. However, introduction of bafilomycin A1 strongly suppressed melanosome degradation in Melasolv-treated cells. Furthermore, inhibition of autophagy by ATG5 resulted in significant suppression of Melasolv-mediated depigmentation in alpha-MSH-treated cells. Taken together, our results suggest that treatment with Melasolv inhibits skin pigmentation by promoting melanosome degradation via autophagy activation. | Park, Hyun Jun; Jo, Doo Sin; Choi, Hyunjung; Bae, Ji-Eun; Park, Na Yeon; Kim, Joon Bum; Choi, Ji Yeon; Kim, Yong Hwan; Oh, Gyeong Seok; Chang, Jeong Ho; Kim, Hyoung-June; Cho, Dong-Hyung | Kyungpook Natl Univ, Sch Life Sci, Daegu, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea; AmorePacific Corp, R&D Unit, Yongin, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Dept Biol Educ, Daegu, South Korea | Kim, Joon/ADP-8066-2022; Choi, Hye Rin/JDV-9065-2023 | 57209409221; 56335489800; 50360927700; 57190605352; 57190609826; 57190611030; 57219085234; 57204676401; 57219084322; 57203598905; 35083721800; 35093684400 | leojune@amorepacific.com;dhcho@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 9 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.36 | 2025-06-25 | 15 | 16 | PROTEIN; DEGRADATION; MELANOGENESIS; MELANOCYTES; UBIQUITIN; MECHANISM; TFEB; LC3 | alpha-MSH; Animals; Autophagosomes; Autophagy; Cell Line, Tumor; Cinnamates; Macrolides; Melanins; Melanocytes; Melanosomes; Mice; Pigmentation; Pigmentation Disorders; Skin Pigmentation; 3,4,5 trimethoxycinnamate thymol ester; alpha intermedin; antineoplastic agent; autophagy related protein 5; bafilomycin A1; melanin; unclassified drug; 3,4,5-trimethoxycinnamic acid; cinnamic acid derivative; macrolide; melanin; animal cell; antineoplastic activity; Article; autophagy (cellular); B16-F1 cell line; cell activation; controlled study; degradation; depigmentation; melanosome; mouse; nonhuman; pigmentation; animal; autophagosome; autophagy; drug effect; melanocyte; melanosome; metabolism; pigment disorder; pigmentation; skin pigmentation; tumor cell line | English | 2020 | 2020-09-17 | 10.1371/journal.pone.0239019 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Metabolic engineering considerations for the heterologous expression of xylose-catabolic pathways inSaccharomyces cerevisiae | Xylose, the second most abundant sugar in lignocellulosic biomass hydrolysates, can be fermented bySaccharomyces cerevisiaeexpressing one of two heterologous xylose pathways: a xylose oxidoreductase pathway and a xylose isomerase pathway. Depending on the type of the pathway, its optimization strategies and the fermentation efficiencies vary significantly. In the present study, we constructed two isogenic strains expressing either the oxidoreductase pathway (XYL123) or the isomerase pathway (XI-XYL3), and delved into simple and reproducible ways to improve the resulting strains. First, the strains were subjected to the deletion ofPHO13, overexpression ofTAL1, and adaptive evolution, but those individual approaches were only effective in the XYL123 strain but not in the XI-XYL3 strain. Among other optimization strategies of the XI-XYL3 strain, we found that increasing the copy number of the xylose isomerase gene (xylA) is the most promising but yet preliminary strategy for the improvement. These results suggest that the oxidoreductase pathway might provide a simpler metabolic engineering strategy than the isomerase pathway for the development of efficient xylose-fermenting strains under the conditions tested in the present study. | Jeong, Deokyeol; Oh, Eun Joong; Ko, Ja Kyong; Nam, Ju-Ock; Park, Hee-Soo; Jin, Yong-Su; Lee, Eun Jung; Kim, Soo Rin | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu, South Korea; Univ Colorado, Renewable & Sustainable Energy Inst RASEI, Boulder, CO 80309 USA; Korea Inst Sci & Technol KIST, Clean Energy Res Ctr, Seoul, South Korea; Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL USA; Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL USA; Kyungpook Natl Univ, Sch Appl Chem Engn, Dept Chem Engn, Daegu, South Korea | Lee, Seung Eun/ABG-1607-2021; Kim, Soo Rin/X-2192-2019; Park, Hee-Soo/AAC-6422-2019; Jeong, Deokyeol/GLR-8021-2022; Jin, Yong-Su/L-4530-2013 | 57191332457; 59716734900; 56603594800; 7201496105; 15751448400; 57204009076; 57239965200; 36659584200 | eunjunglee@knu.ac.kr;soorinkim@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 7 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.86 | 2025-06-25 | 33 | 32 | RECOMBINANT SACCHAROMYCES-CEREVISIAE; PENTOSE-PHOSPHATE PATHWAY; IMPROVES ETHANOL-PRODUCTION; XYLITOL DEHYDROGENASE; FUNCTIONAL EXPRESSION; ADAPTIVE EVOLUTION; ANAEROBIC GROWTH; UP-REGULATION; ACETIC-ACID; ISOMERASE | Aldose-Ketose Isomerases; Biological Evolution; Fermentation; Gene Deletion; Metabolic Engineering; Metabolic Networks and Pathways; Saccharomyces cerevisiae; Transcription, Genetic; Xylose; isomerase; oxidoreductase; xylose; xylose isomerase; isomerase; xylose; xylose isomerase; Article; carbohydrate metabolism; controlled study; evolutionary adaptation; fungal gene; fungal strain; gene deletion; gene dosage; gene overexpression; metabolic engineering; nonhuman; PHO13 gene; reproducibility; Saccharomyces cerevisiae; signal transduction; TAL1 gene; xylA gene; evolution; fermentation; genetic transcription; metabolism | English | 2020 | 2020-07-27 | 10.1371/journal.pone.0236294 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Novel histopathologic predictors for renal outcomes in crescentic glomerulonephritis | Introduction Crescentic glomerulonephritis (CrGN) is a histologic feature of severe glomerular injury, clinically characterized by a rapid decline of renal function when not treated in a timely fashion. Factors associated with CrGN prognosis have not been thoroughly investigated. This study investigated the prognostic predictors of renal outcomes associated with CrGN, such as the histopathologic classification of anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis, arteriosclerosis, and tertiary lymphoid organ (TLO) formation. Methods A total of 114 patients diagnosed with CrGN between 2010 and 2018 at two university-based hospitals has been retrospectively analyzed. Relationships between potential predictors and renal outcomes were analyzed using Cox proportional hazards model and linear regression analysis. Results The mean age was 61.0 +/- 15.3 years, and 49.1% were male. Among them, 92 (80.7%) and 11 (9.6%) patients were positive for ANCA and for anti-glomerular basement membrane antibody, respectively. During the median follow-up of 458.0 days, 55 patients (48.2%) had advanced to end-stage renal disease (ESRD). Cox proportional hazards analysis revealed that patients under the mixed and sclerotic classes had worse renal survival compared to those in the focal class (mixed: hazard ratio [HR], 3.74; 95% confidence interval [CI], 1.18 to 11.82;P= 0.025; sclerotic: HR, 4.84; 95% CI, 1.44 to 16.32;P= 0.011). Severe arteriosclerosis was also associated with poor renal survival (HR, 2.44; 95% CI, 1.04 to 5.77;P= 0.042). TLOs were observed in 41 patients (36.0%). Moreover, TLO formation was also a prognostic factor for ESRD (HR, 1.82; 95% CI, 1.03 to 3.21;P= 0.040). In the multivariate linear regression analysis, age and sclerotic class were independent predictors for the change in estimated glomerular filtration rate during 1 year after biopsy. Conclusions Specific histopathologic findings, histopathologic classification, severity of arteriosclerosis, and TLO formation provide helpful information in predicting renal outcomes associated with CrGN. | Lim, Jeong-Hoon; Han, Man-Hoon; Kim, Yong-Jin; Jeon, Yena; Jung, Hee-Yeon; Choi, Ji-Young; Cho, Jang-Hee; Kim, Chan-Duck; Kim, Yong-Lim; Lee, Hajeong; Kim, Dong Ki; Moon, Kyung Chul; Park, Sun-Hee | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Pathol, Daegu, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Dept Pathol, Coll Med, Seoul, South Korea | Kim, Dong Ki/J-5389-2012; Cho, Jang-hee/ABD-3534-2020; Kim, Yong-Lim/AGK-3172-2022; Lee, Hyo/G-6299-2019; Park, Sun-Hee/LMN-0033-2024; Kim, Yong-Jin/J-2745-2012; Lim, Jeong-Hoon/ABE-6003-2020 | 55360244300; 57194067936; 56150365500; 57209909350; 57196396467; 7501393222; 7403536291; 8558530700; 55633533600; 36554389800; 23479259100; 16025039700; 7501831741 | sh-park@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 7 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.23 | 2025-06-25 | 10 | 10 | ANTIBODY-ASSOCIATED GLOMERULONEPHRITIS; ANCA-ASSOCIATED VASCULITIS; LYMPHOID STRUCTURES; T-CELLS; CLASSIFICATION; CYCLOPHOSPHAMIDE; RITUXIMAB; NEOGENESIS; DEPOSITS; PATHWAY | Female; Glomerulonephritis; Humans; Kidney; Male; Middle Aged; Prognosis; Retrospective Studies; Survival Analysis; glomerulus basement membrane antibody; neutrophil cytoplasmic antibody; adult; age; antibody detection; arteriosclerosis; Article; controlled study; crescentic glomerulonephritis; disease association; disease severity; end stage renal disease; female; follow up; glomerulonephritis; histopathology; human; human cell; human tissue; major clinical study; male; outcome assessment; prediction; prognosis; retrospective study; survival analysis; tertiary lymphoid structure; university hospital; glomerulonephritis; kidney; middle aged; pathology; pathophysiology | English | 2020 | 2020-07-27 | 10.1371/journal.pone.0236051 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Outcomes of kidney transplantation from elderly deceased donors of a Korean registry | To overcome organ shortage, expanded criteria donors, including elderly deceased donors (DDs), should be considered. We analyzed outcomes of kidney transplantation (KT) from elderly DDs in a nationwide study. In total, data of 1049 KTs from DDs using the database of Korean Organ Transplantation Registry (KOTRY) were retrospectively analyzed based on the age of DDs: age >= 60 years vs. = 60 years. Elderly DDs had a significantly higher prevalence of diabetes and hypertension and higher Kidney Donor Risk Index (KDRI) and Kidney Donor Profile Index (KDPI). The mean age of the recipients was 47.45 +/- 14.87 years. Patients who received KT from elderly DDs were significantly older (53.12 +/- 15.14 vs. 45.88 +/- 14.41, P= 60 years and = 60 years. In DDs aged <60 years, thymoglobulin induction (2.62, 1.53-4.48; P<0.001) and continuous renal replacement therapy (3.47, 1.52-7.96; P = 0.003) were significant factors. Our data indicated that graft outcomes, including renal function and DGF, were similar for elderly DDs and DDs aged <60 years. Elderly DDs might be considered tolerable donors for KT, with active preoperative surveillance. | Jun, Heungman; Kim, Yeong Hoon; Kim, Joong Kyung; Kim, Chan-Duck; Yang, Jaeseok; Ahn, Curie; Han, Sang Youb | Inje Univ, Ilsan Paik Hosp, Dept Surg, Coll Med, Goyang, South Korea; Inje Univ, Busan Paik Hosp, Dept Internal Med, Coll Med, Busan, South Korea; Bong Seng Mem Hosp, Dept Internal Med, Div Nephrol, Busan, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Seoul Natl Univ Hosp, Dept Surg, Seoul, South Korea; Seoul Natl Univ, Transplantat Res Inst, Coll Med, Seoul, South Korea; Seoul Natl Univ Hosp, Transplantat Ctr, Seoul, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Inje Univ, Ilsan Paik Hosp, Dept Internal Med, Coll Med, Goyang, South Korea | ; Jun, Heungman/AFN-9427-2022; Han, Seung Seok/HGD-2825-2022; Yang, Jae/LUW-8250-2024; Kim, Hyoungnae/JXN-1329-2024; Kim, Tae-Hee/AAN-9079-2021 | 55508260600; 7410196419; 56508055400; 8558530700; 57212326527; 7201986669; 57216860543; 7202290990; 55420625000; 36183208900; 7402016375; 55653223000; 56212607100; 57203275923; 57189388760; 26432181000; 57218626042; 56682283600; 54955660800; 56119751700; 36162581500; 57226657760; 57216238599; 7407743404; 57737628900; 7501514537; 57218150487; 57199467944; 56597242000; 55890136000; 56875079100; 56028990400; 57218629097; 36120293400; 8443579300; 24773386100; 7403936486; 15755796200; 23471686900; 35784016900; 7403220000; 24281360600; 35183155900 | hansy@paik.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 6 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.18 | 2025-06-25 | 3 | 4 | RENAL-TRANSPLANTATION; OLDER; IMPACT; AGE; EXPERIENCE; INDEX | Adult; Age Factors; Aged; Antilymphocyte Serum; Databases, Factual; Delayed Graft Function; Humans; Kidney; Kidney Transplantation; Middle Aged; Odds Ratio; Registries; Republic of Korea; Retrospective Studies; Risk Factors; Tissue Donors; Treatment Outcome; creatinine; thymocyte antibody; lymphocyte antibody; thymocyte antibody; adult; age; age distribution; aged; anoxia; Article; cerebrovascular accident; cohort analysis; continuous renal replacement therapy; controlled study; deceased donor; delayed graft function; diabetes mellitus; disease risk assessment; extracorporeal oxygenation; female; head injury; human; hypertension; kidney donor; Kidney Donor Risk Index; kidney function; kidney graft; kidney graft rejection; kidney transplantation; lymphocele; major clinical study; male; middle aged; outcome assessment; postoperative hemorrhage; postoperative thrombosis; prevalence; retrospective study; risk factor; sex difference; surgical wound; treatment outcome; urine incontinence; delayed graft function; donor; factual database; kidney; metabolism; odds ratio; pathology; physiology; register; South Korea; treatment outcome | English | 2020 | 2020-06-11 | 10.1371/journal.pone.0232177 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Pharmacological inhibition of carnitine palmitoyl transferase 1 inhibits and reverses experimental autoimmune encephalitis in rodents | Multiple sclerosis (MS) is a neurodegenerative disease characterized by demyelination and inflammation. Dysregulated lipid metabolism and mitochondrial dysfunction are hypothesized to play a key role in MS. Carnitine Palmitoyl Transferase 1 (CPT1) is a rate-limiting enzyme for beta-oxidation of fatty acids in mitochondria. The therapeutic effect of pharmacological CPT1 inhibition with etomoxir was investigated in rodent models of myelin oligodendrocyte glycoprotein- and myelin basic protein-induced experimental autoimmune encephalitis (EAE). Mice receiving etomoxir showed lower clinical score compared to placebo, however this was not significant. Rats receiving etomoxir revealed significantly lower clinical score and lower body weight compared to placebo group. When comparing etomoxir with interferon-beta (IFN-beta), IFN-beta had no significant therapeutic effects, whereas etomoxir treatment starting at day 1 and 5 significantly improved the clinical scores compared to the IFN-beta and the placebo group. Immunohistochemistry and image assessments of brain sections from rats with EAE showed higher myelination intensity and decreased expression of CPT1A in etomoxir-treated rats compared to placebo group. Moreover, etomoxir mediated increased interleukin-4 production and decreased interleukin-17 alpha production in activated T cells. In conclusion, CPT1 is a key protein in the pathogenesis of EAE and MS and a crucial therapeutic target for the treatment. | Morkholt, Anne Skottrup; Oklinski, Michal Krystian; Larsen, Agnete; Bockermann, Robert; Issazadeh-Navikas, Shohreh; Nieland, Jette Goller Kloth; Kwon, Tae-Hwan; Corthals, Angelique; Nielsen, Soren; Nieland, John Dirk Vestergaard | Aalborg Univ, Dept Hlth Sci & Technol, Aalborg, Denmark; Aarhus Univ, Dept Biomed, Aarhus C, Denmark; Univ Copenhagen, Biotech Res & Innovat Ctr, Copehage N, Denmark; ApS, Meta IQ, Aarhus C, Denmark; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Taegu, South Korea; CUNY, Dept Sci, John Jay Coll Criminal Justice, New York, NY 10021 USA | Kwon, Tae-Hwan/ABA-1981-2020; Issazadeh-Navikas, Shohreh/AAI-7900-2021; Oklinski, Michal/S-9651-2017 | 57194398877; 36610639900; 57223814323; 6506958931; 6507671335; 57194396604; 7202206089; 54879970600; 59624693600; 6603938873 | jdn@hst.aau.dk; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 6 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.68 | 2025-06-25 | 23 | 22 | MULTIPLE-SCLEROSIS; INTERFERON-BETA; PROTEIN; METABOLISM; DEPRESSION; DISEASE; MODEL | Animals; Brain; Carnitine O-Palmitoyltransferase; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Epoxy Compounds; Female; Interleukin-17; Interleukin-4; Mice; Mice, Inbred C57BL; Myelin Sheath; Rats; Rats, Inbred Lew; carnitine palmitoyltransferase I; etomoxir; ferritin; interleukin 17; interleukin 4; interleukin 8; placebo; recombinant beta interferon; tumor necrosis factor; carnitine palmitoyltransferase; enzyme inhibitor; epoxide; etomoxir; interleukin 17; interleukin 4; allergic encephalitis; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; body weight; C57BL 6 mouse; clinical outcome; controlled study; cytokine production; down regulation; drug effect; drug efficacy; drug inhibition; drug mechanism; drug targeting; enzyme inhibition; female; immunohistochemistry; Lewis rat; lymphocyte activation; medial longitudinal fasciculus; mouse; mouse model; myelination; nonhuman; pathogenesis; protein expression; raphe magnus nucleus; rat; rat model; T lymphocyte; animal; brain; C57BL mouse; experimental autoimmune encephalomyelitis; genetics; metabolism; myelin sheath | English | 2020 | 2020-06-10 | 10.1371/journal.pone.0234493 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Phenotype and molecular signature of CD8⁺ T cell subsets in T cell- mediated rejections after kidney transplantation | We investigated the phenotype and molecular signatures of CD8(+)T cell subsets in kidney-transplant recipients (KTRs) with biopsy-proven T cell-mediated rejection (TCMR). We included 121 KTRs and divided them into three groups according to the pathologic or clinical diagnosis: Normal biopsy control (NC)(n= 32), TCMR (n= 50), and long-term graft survival (LTGS)(n= 39). We used flowcytometry and microarray to analyze the phenotype and molecular signatures of CD8(+)T cell subsets using peripheral blood from those patients and analyzed significant gene expressions according to CD8(+)T cell subsets. We investigated whether the analysis of CD8(+)T cell subsets is useful for predicting the development of TCMR. CCR7(+)CD8(+)T cells significantly decreased, but CD28(null)CD57(+)CD8(+)T cells and CCR7(-)CD45RA(+)CD8(+)T cells showed an increase in the TCMR group compared to other groups (p<0.05 for each); hence CCR7(+)CD8(+)T cells showed significant negative correlations to both effector CD8(+)T cells. We identified genes significantly associated with the change of CCR7(+)CD8(+)T, CCR7(-)CD45RA(+)CD8(+)T, and CD28(null)CD57(+)CD8(+)T cells in anex vivostudy and found that most of them were included in the significant genes onin vitroCCR7(+)CD8(+)T cells. Finally, the decrease of CCR7(+)CD8(+)T cells relative to CD28(null)CD57(+)T or CCR7(-)CD45RA(+)CD8(+)T cells can predict TCMR significantly in the whole clinical cohort. In conclusion, phenotype and molecular signature of CD8(+)T subsets showed a significant relationship to the development of TCMR; hence monitoring of CD8(+)T cell subsets may be a useful for predicting TCMR in KTRs. | Ko, Eun Jeong; Seo, Jung-Woo; Kim, Kyoung Woon; Kim, Bo-Mi; Cho, Jang-Hee; Kim, Chan-Duck; Seok, Junhee; Yang, Chul Woo; Lee, Sang-Ho; Chung, Byung Ha | Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Convergent Res Consortium Immunol Dis, Seoul, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea; Kyung Hee Univ Hosp Gangdong, Med Sci Res Inst, Dept Core Res Lab, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Korea Univ, Sch Elect Engn, Seoul, South Korea; Kyung Hee Univ, Coll Med, Dept Internal Med, Seoul, South Korea | ; Kim, Hyungduk/CAH-5630-2022; Cho, Jang-hee/ABD-3534-2020; Kim, Hyoungnae/JXN-1329-2024; Kim, Eun/AAS-6706-2020 | 57194720455; 56678212900; 9745815400; 57192930726; 7403536291; 8558530700; 24069490100; 7407743404; 55890136000; 57201863822 | lshkidney@khu.ac.kr;chungbh@catholic.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 6 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.18 | 2025-06-25 | 11 | 12 | MICROARRAYS; RECIPIENTS; CD28 | Adult; CD28 Antigens; CD57 Antigens; CD8-Positive T-Lymphocytes; Cross-Sectional Studies; Female; Gene Expression Profiling; Graft Rejection; Healthy Volunteers; Humans; Immunophenotyping; In Vitro Techniques; Kidney Transplantation; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; Phenotype; Receptors, CCR7; T-Lymphocyte Subsets; CD45RA antigen; CD57 antigen; chemokine receptor CCR7; CCR7 protein, human; CD28 antigen; CD57 antigen; chemokine receptor CCR7; acute graft rejection; adult; Article; CD8+ T lymphocyte; controlled study; effector cell; ex vivo study; female; flow cytometry; gene expression; human; human cell; human tissue; in vitro study; kidney allograft rejection; kidney transplantation; major clinical study; male; microarray analysis; prediction; receiver operating characteristic; regulatory T lymphocyte; single cell analysis; T cell mediated rejection; transcriptomics; adverse event; CD8+ T lymphocyte; classification; cross-sectional study; DNA microarray; gene expression profiling; genetics; graft rejection; immunology; immunophenotyping; kidney transplantation; middle aged; normal human; phenotype; T lymphocyte subpopulation | English | 2020 | 2020-06-12 | 10.1371/journal.pone.0234323 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Radiomics signature for prediction of lateral lymph node metastasis in conventional papillary thyroid carcinoma | Purpose Preoperative neck ultrasound (US) for lateral cervical lymph nodes is recommended for all patients undergoing thyroidectomy for thyroid malignancy, but it is operator dependent. We aimed to develop a radiomics signature using US images of the primary tumor to preoperatively predict lateral lymph node metastasis (LNM) in patients with conventional papillary thyroid carcinoma (cPTC). Methods Four hundred consecutive cPTC patients from January 2004 to February 2006 were enrolled as the training cohort, and 368 consecutive cPTC patients from March 2006 to February 2007 served as the validation cohort. A radiomics signature, which consisted of 14 selected features, was generated by the least absolute shrinkage and selection operator (LASSO) regression model in the training cohort. The discriminating performance of the radiomics signature was assessed in the validation cohort with the area under the receiver operating characteristic curve (AUC). Results The radiomics signature was significantly associated with lateral cervical lymph node status (p < 0.001). The AUC of its performance in discriminating metastatic and non-metastatic lateral cervical lymph nodes was 0.710 (95% CI: 0.649-0.770) in the training cohort and was 0.621 (95% CI: 0.560-0.682) in the validation cohort. Conclusions The present study showed that US radiomic features of the primary tumor were associated with lateral cervical lymph node status. Although their discriminatory performance was slightly lower in the validation cohort, our study shows that US radiomic features of the primary tumor alone have the potential to predict lateral LNM. | Park, Vivian Y.; Han, Kyunghwa; Kim, Hye Jung; Lee, Eunjung; Youk, Ji Hyun; Kim, Eun-Kyung; Moon, Hee Jung; Yoon, Jung Hyun; Kwak, Jin Young | Yonsei Univ, Severance Hosp, Res Inst Radiol Sci, Dept Radiol,Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Radiol, Daegu, South Korea; Yonsei Univ, Dept Computat Sci & Engn, Seoul, South Korea; Yonsei Univ, Gangnam Severance Hosp, Res Inst Radiol Sci, Dept Radiol,Coll Med, Seoul, South Korea | ; Yoon, Jung Hyun/KHX-0113-2024; Lee, Eunjung/F-6671-2013; Kim, Eun-Kyung/E-5211-2017 | 55859436900; 57205679159; 57203506201; 59109567500; 7003994943; 57193801548; 35330281300; 36629726900; 7202648908 | docjin@yuhs.ac; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 1.4 | 2025-06-25 | 52 | 51 | PREOPERATIVE DIAGNOSIS; PROGNOSTIC-FACTORS; TEXTURE ANALYSIS; NODULES; CANCER; ULTRASOUND; MALIGNANCY; GUIDELINES; BENIGN; KOREA | Adult; Female; Humans; Lymph Nodes; Lymphatic Metastasis; Magnetic Resonance Imaging; Male; Middle Aged; Neck; Nomograms; ROC Curve; Thyroid Cancer, Papillary; Thyroidectomy; Ultrasonic Therapy; Ultrasonic Waves; adult; Article; cancer patient; cancer prognosis; cervical lymph node metastasis; cohort analysis; controlled study; conventional papillary thyroid carcinoma; diagnostic test accuracy study; echography; female; human; image segmentation; lymph node metastasis; major clinical study; male; primary tumor; radiomics; receiver operating characteristic; retrospective study; sensitivity and specificity; thyroid papillary carcinoma; validation study; diagnostic imaging; lymph node; lymph node metastasis; middle aged; neck; nomogram; nuclear magnetic resonance imaging; pathology; procedures; radiation response; radiotherapy; surgery; thyroidectomy; ultrasound; ultrasound therapy | English | 2020 | 2020-01-15 | 10.1371/journal.pone.0227315 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Tacrolimus trough levels higher than 6 ng/mL might not be required after a year in stable kidney transplant recipients | Background Little is known regarding optimal tacrolimus (TAC) trough levels after 1 year post-transplant in stable kidney transplant recipients (KTRs) who have not experienced renal or cardiovascular outcomes. This study aimed to investigate the effect of 1-year post-transplant TAC trough levels on long-term renal and cardiovascular outcomes and opportunistic infections in stable KTRs. Methods KTRs receiving TAC with mycophenolate-based immunosuppression who did not experience renal or cardiovascular outcomes within 1 year post-transplant were enrolled from a multicenter observational cohort study. Renal outcome was defined as a composite of biopsy-proven acute rejection, interstitial fibrosis and tubular atrophy, and death-censored graft loss. Cardiovascular outcome was defined as a composite of de novo cardiomegaly, left ventricular hypertrophy, and cardiovascular events. Opportunistic infections were defined as the occurrence of BK virus or cytomegalovirus infections. Results A total of 603 eligible KTRs were divided into the low-level TAC (LL-TAC) and high-level TAC (HL-TAC) groups based on a median TAC level of 5.9 ng/mL (range 1.3-14.3) at 1 year post-transplant. The HL-TAC group had significantly higher TAC trough levels at 2, 3, 4, and 5 years compared with the levels of the LL-TAC group. During the mean follow-up of 63.7 +/- 13.0 months, there were 121 renal outcomes and 224 cardiovascular outcomes. In multivariate Cox regression analysis, LL-TAC and HL-TAC were not independent risk factors for renal and cardiovascular outcomes, respectively. No significant differences in the development of opportunistic infections and de novo donor-specific anti-human leukocyte antigen antibodies and renal allograft function were observed between the two groups. Conclusions TAC trough levels after 1 year post-transplant remained at a similar level until the fifth year after kidney transplantation and were not directly associated with long-term outcomes in stable Korean KTRs who did not experience renal or cardiovascular outcomes. Therefore, in Asian KTRs with a stable clinical course, TAC trough levels higher than approximately 6 ng/mL might not be required after a year of kidney transplantation. | Jung, Hee-Yeon; Seo, Min Young; Jeon, Yena; Huh, Kyu Ha; Park, Jae Berm; Jung, Cheol Woong; Lee, Sik; Han, Seung-Yeup; Ro, Han; Yang, Jaeseok; Ahn, Curie; Choi, Ji-Young; Cho, Jang-Hee; Park, Sun-Hee; Kim, Yong-Lim; Kim, Chan-Duck | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Pohang St Marys Hosp, Dept Internal Med, Pohang, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Yonsei Univ, Dept Surg, Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Seoul Samsung Med Ctr, Dept Surg, Seoul, South Korea; Korea Univ, Dept Surg, Coll Med, Seoul, South Korea; Chonbuk Natl Univ Hosp, Dept Internal Med, Jeonju, South Korea; Keimyung Univ, Dept Internal Med, Dongsan Med Ctr, Daegu, South Korea; Gachon Univ, Gil Hosp, Dept Internal Med, Incheon, South Korea; Seoul Natl Univ, Dept Surg, Coll Med, Seoul, South Korea; Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea | Kim, Yong-Lim/AGK-3172-2022; Yang, Jae/LUW-8250-2024; Jung, Hee-Yeon/AFB-8578-2022; Han, Seung Seok/HGD-2825-2022; Cho, Jang-hee/ABD-3534-2020 | 57196396467; 58457049900; 57209909350; 35183155900; 13605451500; 7402016375; 57192521521; 24281360600; 26538034700; 57212326527; 7201986669; 7501393222; 7403536291; 7501831741; 55633533600; 8558530700 | drcdkim@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 7 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.09 | 2025-06-25 | 4 | 3 | EXTENDED-RELEASE TACROLIMUS; ACUTE REJECTION; RISK; DISEASE; NEPHROPATHY; MORTALITY; FAILURE; IMPACT | Adult; Cardiovascular Diseases; Cohort Studies; Cytomegalovirus Infections; Female; Graft Rejection; Humans; Immunosuppression; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Opportunistic Infections; Polyomavirus Infections; Renal Insufficiency; Republic of Korea; Tacrolimus; leukocyte antibody; leukocyte antigen; mycophenolic acid; tacrolimus; immunosuppressive agent; tacrolimus; acute graft rejection; adult; Article; BK virus; bk virus infection; BK virus nephropathy; cardiomegaly; clinical outcome; cytomegalovirus infection; female; fibrosing alveolitis; graft failure; graft recipient; human; kidney allograft; kidney biopsy; kidney graft; long term survival; major clinical study; male; polymerase chain reaction; risk factor; adverse event; blood; cardiovascular disease; clinical trial; cohort analysis; cytomegalovirus infection; graft rejection; immunosuppressive treatment; kidney failure; kidney transplantation; middle aged; multicenter study; opportunistic infection; polyomavirus infection; rehabilitation; South Korea | English | 2020 | 2020-07-02 | 10.1371/journal.pone.0235418 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | The relationship of moral sensitivity and patient safety attitudes with nursing students' perceptions of disclosure of patient safety incidents: A cross-sectional study | Disclosure of patient safety incidents is a healthcare management strategy that primarily involves responding after incidents. We investigated the association between nursing students' moral sensitivity, attitudes about patient safety, and perceptions of open disclosure of patient safety incidents in Korea. Data were collected from 407 nursing students at four nursing universities using self-reported moral sensitivity, attitudes about patient safety, and perceptions about open disclosure of patient safety incidents as measures. The data were analyzed using t-test, one-way analysis of variance, and a multiple regression. As moral sensitivity and attitudes about patient safety improved, nursing students' perceptions regarding the open disclosure of patient safety incidents improved significantly. After controlling for gender, grade, and major satisfaction, the effect of changing attitudes about patient safety was greater than that of moral sensitivity for all perceptions of open disclosure. An education and intervention program is needed to improve nursing students' attitudes about patient safety and promote the open disclosure of patient safety incidents during undergraduate training. | Lee, Eunmi; Kim, Yujeong | Hoseo Univ, Dept Nursing, Asan, Chungcheongnamd, South Korea; Kyungpook Natl Univ, Coll Nursing, Daegu, South Korea | Lee, Eunmi/AAS-2561-2020 | 57202264064; 57200941945 | cybericu@naver.com; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 1.2 | 2025-06-25 | 23 | 30 | MEDICAL ERRORS; PHYSICIANS; COMMUNICATION; EXPERIENCES; QUALITY | Adult; Attitude; Attitude of Health Personnel; Cross-Sectional Studies; Disclosure; Female; Humans; Male; Morals; Patient Safety; Republic of Korea; Students, Nursing; Surveys and Questionnaires; Truth Disclosure; Universities; Young Adult; adult; analysis of variance; article; attitude; cross-sectional study; drug safety; education; female; gender; human; Korea; major clinical study; male; morality; multiple regression; nursing student; patient safety; perception; satisfaction; attitude; cross-sectional study; ethics; health personnel attitude; interpersonal communication; morality; nursing student; patient safety; psychology; questionnaire; South Korea; university; young adult | English | 2020 | 2020-01-10 | 10.1371/journal.pone.0227585 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | The usefulness of Time-of-Flight MR angiography in detection of intraplaque hemorrhage in patients with acute ischemic stroke with symptomatic carotid stenosis | Objective Carotid intraplaque hemorrhage (IPH) is a well-known risk indicator of thromboembolism, but it is not easy to rapidly detect IPH in acute symptomatic carotid disease. The aim of this study was to assess the utility of time-of-flight (TOF) magnetic resonance angiography (MRA) in the detection of IPH and evaluate the degree of stenosis and stroke patterns in patients with acute symptomatic carotid disease. Methods We retrospectively identified consecutive patients with acute symptomatic carotid disease who were admitted within 12 h after stroke onset. Fifty-nine patients underwent TOF MRA at admission and were categorized according to the presence or absence of intraplaque high signal intensity (HSI). The severity of carotid stenosis and diffusion-weighted magnetic resonance imaging lesion patterns were evaluated. Results Intraplaque HSI was detected in 28.8% of the enrolled patients (17/59). Mild-to-moderate symptomatic carotid stenosis was more frequent in the intraplaque HSI-positive group (70.6%) than in the intraplaque HSI-negative group (42.8%) (p = 0.015). The patients with intraplaque HSI more frequently exhibited a disseminated small infarction pattern (76.5% in the intraplaque HSI-positive group, 47.6% in the -negative group), and did not exhibit a border-zone infarction pattern (0% in the positive group, 16.7% in the negative group). Conclusions TOF MRA may be a useful noninvasive and rapid tool to detect IPH in patients with acute symptomatic carotid disease. IPH was common in those with a lower degree of carotid stenosis and manifested as a disseminated small infarction pattern. Intraplaque HSI on TOF MRA in acute symptomatic carotid disease may help to determine the mechanism of stroke and establish early treatment plans. | Gwak, Dong-Seok; Kim, Baik-Kyun; Chung, Inyoung; Han, Moon-Ku | Kyungpook Natl Univ Hosp, Dept Neurol, Daegu, South Korea; Chungbuk Natl Univ Hosp, Dept Neurol, Cheongju, Chungcheongbuk, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Medicare Syst, Seongnam Si, Gyeonggi Do, South Korea; Seoul Natl Univ, Coll Med, Bundang Hosp, Dept Neurol, Seongnam Si, Gyeonggi Do, South Korea | ; Han, Moon-Ku/J-5703-2012 | 57205148053; 57205147789; 57194595472; 35361858400 | mkhan@snu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 2 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.05 | 2025-06-25 | 3 | 2 | PREPARED RAPID ACQUISITION; ARTERY; INFARCTION; PLAQUES; EVENTS; SIGNAL; RISK | Aged; Aged, 80 and over; Brain Ischemia; Carotid Stenosis; Female; Hemorrhage; Humans; Magnetic Resonance Angiography; Male; Middle Aged; Retrospective Studies; Stroke; acetylsalicylic acid; acetylsalicylic acid plus clopidogrel; clopidogrel; aged; Article; brain infarction; brain ischemia; carotid artery obstruction; carotid atherosclerosis; diffusion weighted imaging; disease severity; female; hospital admission; human; magnetic resonance angiography; major clinical study; male; neuroimaging; observational study; retrospective study; signal processing; time of flight mass spectrometry; bleeding; brain ischemia; carotid artery obstruction; cerebrovascular accident; diagnostic imaging; magnetic resonance angiography; middle aged; procedures; very elderly | English | 2020 | 2020-02-13 | 10.1371/journal.pone.0229024 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Treatment pattern and overall survival in esophageal cancer during a 13-year period: A nationwide cohort study of 6,354 Korean patients | Using data from the real world to solve clinical questions that cannot be answered using data from clinical trials is attracting more attention. Clinical outcomes for patients with esophageal cancer in a real-world setting might be different from data in randomized controlled trials. This study aimed to provide real world data on treatment and prognosis in Korean patients with esophageal cancer. This retrospective cancer cohort included newly diagnosed cases of esophageal cancer at 19 tertiary hospitals between January 1, 2005 and December 31, 2017. Cancer staging was defined according to the 7th edition of the American Joint Committee on Cancer criteria. We identified 6,354 patients with newly diagnosed esophageal cancer (mean age: 64.9 +/- 9.0 years, 96.9% squamous cell carcinoma). The proportion of early esophageal cancer increased from 24.7% in 2005 to 37.2% in 2015 (p<0.001). Among all cases, surgery alone was 31.3%, followed by definitive concurrent chemoradiotherapy (CCRT) (27.0%), neoadjuvant therapy (12.4%), adjuvant therapy (11.1%), and endoscopic resection (5.8%). The 5-year overall survival rate was 45.7 +/- 0.7%. Endoscopic resection provided similar median survival relative to surgery for stage Ia cases. Among stage II-III cases, definitive CCRT was associated with poorer survival than neoadjuvant or adjuvant therapy, although there was no survival difference between neoadjuvant and adjuvant therapy. Early esophageal cancer is gradually becoming more common and endoscopic resection provided similar long-term survival relative to surgery. Surgery with combined therapy provided better survival in locally advanced esophageal cancer, relative to definitive CCRT. | Jung, Hye-Kyung; Tae, Chung Hyun; Lee, Hye-Ah; Lee, Hyuk; Choi, Kee Don; Park, Jun Chul; Kwon, Joong Goo; Choi, Yoon Jin; Hong, Su Jin; Sung, Jaekyu; Chung, Woo Chul; Kim, Ki Bae; Kim, Seung Young; Song, Kyung Ho; Park, Kyung Sik; Jeon, Seong Woo; Kim, Byung-Wook; Ryu, Han Seung; Lee, Ok-Jae; Baik, Gwang Ho; Kim, Yong Sung; Jung, Hwoon-Yong | Ewha Womans Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Dept Med, Samsung Med Ctr, Sch Med, Seoul, South Korea; Univ Ulsan, Dept Gastroenterol, Asan Med Ctr, Coll Med, Seoul, South Korea; Yonsei Univ, Dept Internal Med, Inst Gastroenterol, Coll Med, Seoul, South Korea; Daegu Catholic Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Gyeonggi Do, South Korea; Soonchunhyang Univ, Ctr Digest Dis, Coll Med, Bucheon, South Korea; Soonchunhyang Univ, Res Inst, Coll Med, Bucheon, South Korea; Chungnam Natl Univ, Dept Internal Med, Chungnam Natl Univ Hosp, Coll Med, Daejeon, South Korea; Catholic Univ Korea, St Vincent Hosp, Dept Internal Med, Suwon, South Korea; Chungbuk Natl Univ Hosp, Dept Internal Med, Cheongju, South Korea; Korea Univ, Div Gastroenterol, Dept Internal Med, Ansan Hosp, Seoul, South Korea; Konyang Univ Hosp, Div Gastroenterol & Hepatol, Dept Internal Med, Daejeon, South Korea; Keimyung Univ, Dept Internal Med, Coll Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Catholic Univ Korea, Incheon St Marys Hosp, Dept Internal Med, Coll Med, Incheon, South Korea; Wonkwang Univ, Dept Internal Med, Sch Med, Iksan, South Korea; Wonkwang Univ, Digest Dis Res Inst, Sch Med, Iksan, South Korea; Gyeongsang Natl Univ, Dept Internal Med, Coll Med, Jinju, South Korea; Gyeongsang Natl Univ, Inst Hlth Sci, Jinju, South Korea; Hallym Univ, Coll Med, Dept Internal Med, Chuncheon Sacred Heart Hosp, Chunchon, South Korea; Wonkwang Digest Dis Res Inst, Gunpo, South Korea | Kim, Yong Sung/GMW-8652-2022; Jeon, Seongwoo/AAU-4618-2020; Lee, Hye Ah/ABC-8131-2021; Lee, Da Young/AAA-1843-2021; Kim, Ki Bae/KYQ-0127-2024; Park, Jun/H-7218-2019; Lee, Yoojin/AAB-9799-2022; LEE, KYUNG-HAN/HPD-9299-2023 | 7403029723; 35211966400; 57188947704; 54896123100; 14621577200; 15036123800; 12779951100; 57209841798; 35285527200; 8439931900; 35075629400; 56106965700; 24766250100; 8514620000; 56903328900; 9733636500; 57216356690; 55988304200; 8569374900; 7801423477; 57196171210; 7403029804 | hwoonymd@gmail.com; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 4 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 1.18 | 2025-06-25 | 40 | 41 | ADENOCARCINOMA; CARCINOMA; SURGERY | Aged; Chemoradiotherapy; Combined Modality Therapy; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Esophagus; Female; Humans; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Prognosis; Republic of Korea; Retrospective Studies; Survival Rate; antineoplastic agent; adult; aged; Article; cancer prognosis; cancer staging; chemoradiotherapy; cohort analysis; endoscopic surgery; esophagus cancer; esophagus surgery; female; human; Korean (people); major clinical study; male; median survival time; neoadjuvant therapy; overall survival; retrospective study; squamous cell carcinoma; esophageal squamous cell carcinoma; esophagus; esophagus resection; esophagus tumor; middle aged; mortality; multimodality cancer therapy; pathology; procedures; prognosis; South Korea; survival rate | English | 2020 | 2020-04-10 | 10.1371/journal.pone.0231456 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Unusual genome expansion and transcription suppression in ectomycorrhizal Tricholoma matsutake by insertions of transposable elements | Genome sequencing of Tricholoma matsutake revealed its unusually large size as 189.0 Mbp, which is a consequence of extraordinarily high transposable element (TE) content. We identified that 702 genes were surrounded by TEs, and 83.2% of these genes were not transcribed at any developmental stage. This observation indicated that the insertion of TEs alters the transcription of the genes neighboring these TEs. Repeat-induced point mutation, such as C to T hypermutation with a bias over "CpG" dinucleotides, was also recognized in this genome, representing a typical defense mechanism against TEs during evolution. Many transcription factor genes were activated in both the primordia and fruiting body stages, which indicates that many regulatory processes are shared during the developmental stages. Small secreted protein genes (<300 aa) were dominantly transcribed in the hyphae, where symbiotic interactions occur with the hosts. Comparative analysis with 37 Agaricomycetes genomes revealed that IstB-like domains (PF01695) were conserved across taxonomically diverse mycorrhizal genomes, where the T. matsutake genome contained four copies of this domain. Three of the IstB-like genes were overexpressed in the hyphae. Similar to other ectomycorrhizal genomes, the CAZyme gene set was reduced in T. matsutake, including losses in the glycoside hydrolase genes. The T. matsutake genome sequence provides insight into the causes and consequences of genome size inflation. | Min, Byoungnam; Yoon, Hyeokjun; Park, Julius; Oh, Youn-Lee; Kong, Won-Sik; Kim, Jong-Guk; Choi, In-Geol | Korea Univ, Dept Biotechnol, Coll Life Sci & Biotechnol, Seoul, South Korea; Kyungpook Natl Univ, Sch Life Sci & Biotechnol, Coll Nat Sci, Daegu, South Korea; RDA, NIHHS, Mushroom Res Div, Eumseong, South Korea; Univ Calif Berkeley, Dept Plant & Microbial Biol, Berkeley, CA 94720 USA | ; Choi, In-Geol/F-3152-2013 | 55979055500; 24759572800; 57214117557; 56625479300; 57201056744; 35277198800; 7401471671 | wskong@korea.kr;kimjg@knu.ac.kr;igchoi@korea.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.59 | 2025-06-25 | 15 | 15 | INDUCED POINT MUTATION; SCHIZOPHYLLUM-COMMUNE; SEQUENCE; ANNOTATION; MODEL; MECHANISMS; EXPRESSION; ALIGNMENT; PROVIDES; SIGNALP | Ascomycota; Basidiomycota; DNA Transposable Elements; Gene Expression Regulation, Fungal; Genome, Fungal; Molecular Sequence Annotation; Mycorrhizae; Symbiosis; Transcription, Genetic; Tricholoma; Whole Genome Sequencing; GABA transporter 1; guanosine triphosphatase; hydrophobin; neprosin; peptidase; phosphatase; unclassified drug; amino acid substitution; Article; bri1 gene; c2h2 gene; CAZyme gene; controlled study; CpG island; developmental stage; DNA sequence; down regulation; enzyme activity; fruiting body; fst3 gene; fst4 gene; fungal gene; fungal genome; fungus hyphae; gat1 gene; gene cluster; gene expression; gene frequency; gene identification; gene sequence; genome size; hom1 gene; hom2 gene; mycorrhiza; nonhuman; phylogenetic tree; phylogeny; point mutation; primordium; ribosome; RNA binding; RNA sequence; start codon; stop codon; symbiosis; transcription regulation; transposon; Tricholoma matsutake; upregulation; Ascomycetes; Basidiomycetes; fungal genome; gene expression regulation; genetic transcription; genetics; molecular genetics; transposon; Tricholoma; whole genome sequencing | English | 2020 | 2020-01-24 | 10.1371/journal.pone.0227923 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Association between clinical risk factors and severity of dysphagia after extubation based on a videofluoroscopic swallowing study | Background/Aims: This study aimed to evaluate the correlation between clinical risk factors of post-extubation dysphagia (PED) and the severity of impaired pharyngeal swallowing function assessed via videofluoroscopic swallowing studies (VFSSs). Methods: This study was a retrospective review of medical records. Of 116 patients who were admitted to the intensive care unit and underwent VFSS, 32 who had non-neurologic disorders and experienced prolonged intubation (for more than 48 hours) were diagnosed with PED. The severity of PED was evaluated by using a functional dysphagia scale (FDS) and a penetration aspiration scale (PAS), on the basis of VFSS. Results: The Simplified Acute Physiology Score 3 and total FDS score were positively correlated (r = 0.40, p = 0.02). Intubation duration was positively correlated with total PAS and FDS scores (r = 0.62, p < 0.001; r = 0.65, p < 0.001, respectively). The amounts of residue in the valleculae (RV) and pyriform sinuses (RP) were associated with intubation duration (r = 0.58, p < 0.001; r = 0.57, p < 0.004 respectively). Multivariate regression analysis revealed that intubation duration was significantly associated with the total FDS score, RV and RP subscales of the FDS, and total PAS score. Conclusions: The severity of impaired swallowing function, particularly the amount of residue in the pharyngeal recesses assessed via VFSS, was strongly associated with both severity of medical illness and intubation duration. Intubation duration could be a prognostic factor for assessing impaired swallowing function on the basis of VFSS. | Yang, Won-Jong; Park, Eunhee; Min, Yu-Sun; Huh, Jae-Won; Kim, Ae Ryoung; Oh, Hyun-Min; Nam, Tae-Woo; Jung, Tae-Du | Kyungpook Natl Univ, Chilgok Hosp, Dept Rehabil Med, 807 Hoguk Ro, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Rehabil Med, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Rehabil Med, Daegu, South Korea | 57200985727; 56107216400; 48061349800; 57200984728; 57196257330; 57200994449; 55438580300; 36622364500 | teedo522@knu.ac.kr;teed0522@knu.ac.kr; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 35 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.884 | 35.6 | 0.46 | 2025-06-25 | 13 | 10 | Post-extubation dysphagia; Videofluoroscopic swallowing study; Intubation, intratracheal; Deglutition disorders; Extubation | FIBEROPTIC ENDOSCOPIC EVALUATION; INTENSIVE-CARE-UNIT; PROLONGED ENDOTRACHEAL INTUBATION; CRITICAL ILLNESS POLYNEUROPATHY; POSTEXTUBATION DYSPHAGIA; ASPIRATION; COMPLICATIONS; DYSFUNCTION; PNEUMONIA; WEAKNESS | Deglutition disorders; Extubation; Intratracheal; Intubation; Post-extubation dysphagia; Videofluoroscopic swallowing study | Airway Extubation; Deglutition; Deglutition Disorders; Humans; Retrospective Studies; Risk Factors; aged; Article; controlled study; disease severity; dysphagia; endotracheal intubation; ENT examination; female; Functional Dysphagia Scale; human; intensive care unit; major clinical study; male; Penetration Aspiration Scale; post extubation dysphagia; prognosis; pyriform sinus; rating scale; retrospective study; risk factor; Simplified Acute Physiology Score; videofluoroscopic swallowing study; adverse event; diagnostic imaging; dysphagia; extubation; swallowing | English | 2020 | 2020-01 | 10.3904/kjim.2018.055 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Changes in performance of small bowel capsule endoscopy based on nationwide data from a Korean Capsule Endoscopy Registry | Background/Aims: Capsule endoscopy (CE) is widely used for the diagnosis of small bowel diseases. The clinical performance and complications of small bowel CE, including completion rate, capsule retention rate, and indications, have been previously described in Korea. This study aimed at estimating the recent changes in clinical performance and complications of small bowel CE based on 17-year data from a Korean Capsule Endoscopy Registry. Methods: CE registry data from 35 hospitals were retrospectively analyzed. Clinical information, including completion rate, capsule retention rate, and indications, was collected and analyzed. In addition, the most recent 5-year data for CE examinations were compared with the previous 12-year data. Results: A total of 4,650 CE examinations were analyzed. The most common indication for CE was obscure gastrointestinal bleeding (OGIB). The overall incomplete examination rate was 16% and the capsule retention rate was 3%. Crohn's disease was a risk factor for capsule retention. Inadequate bowel preparation was significantly associated with capsule retention and incomplete examination. An indication other than OGIB was a risk factor for incomplete examination. A recent increasing trend of CE diagnosis of Crohn's disease was observed. The most recent 5-year incomplete examination rate for CE examinations decreased compared with that of the previous 12 years. Conclusions: The 17-year data suggested that CE is a useful and safe tool for diagnosing small bowel diseases. The incomplete examination rate of CE decreased with time, and OGIB was consistently the main indication for CE. Inadequate bowel preparation was significantly associated with capsule retention and incomplete examination. | Kim, Su Hwan; Lim, Yun Jeong; Park, Junseok; Shim, Ki-Nam; Yang, Dong-Hoon; Chun, Jaeyoung; Kim, Jin Su; Lee, Hyun Seok; Chun, Hoon Jai | Seoul Natl Univ, Boramae Med Ctr, Seoul Metropolitan Govt, Dept Internal Med, Seoul, South Korea; Dongguk Univ, Ilsan Hosp, Dept Internal Med, 27 Dongguk Ro, Goyang 10326, South Korea; Soonchunhyang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Ewha Womans Univ, Sch Med, Dept Internal Med, Seoul, South Korea; Univ Ulsan, Coll Med, Dept Internal Med, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Korea Univ, Coll Med, Dept Internal Med, Seoul, South Korea | Park, Junseok/AAZ-2348-2020; Chun, Jaeyoung/G-2921-2015; kim, jinsu/JEP-4929-2023; Yang, Dong-Hoon/B-3437-2015; KIM, SUHWAN/GSE-0120-2022 | 57200822702; 56501161800; 57201131480; 13604838300; 8723912200; 55936772800; 55872317100; 36647886100; 7202215162 | drlimyj@gmail.com; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 35 | 4 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.884 | 35.6 | 0.86 | 2025-06-25 | 13 | 16 | Capsule endoscopy; Intestine; small; Retention; Bowel preparation | DOUBLE-BALLOON ENDOSCOPY; RETENTION RATES; COMPLETION; ENTEROSCOPY; LIMITATIONS; INTERVAL; QUALITY | Bowel preparation; Capsule endoscopy; Intestine; Retention; Small | Capsule Endoscopy; Gastrointestinal Hemorrhage; Humans; Intestine, Small; Registries; Republic of Korea; Retrospective Studies; adenomatous polyp; adult; angiodysplasia; Article; Behcet enteritis; capsule endoscopy; congestive enteropathy; controlled study; Crohn disease; Dieulafoy disease; eosinophilic enteritis; female; gastrointestinal hemorrhage; hemangioma; hemorrhagic enteropathy; human; intestine preparation; intestine ulcer; ischemic enteritis; lymphangioma; major clinical study; male; middle aged; NSAID enteropathy; Peutz Jeghers syndrome; radiation enteropathy; retrospective study; risk factor; small intestine disease; small intestine tumor; telangiectasia; treatment indication; tuberculous enteritis; diagnostic imaging; gastrointestinal hemorrhage; register; small intestine; South Korea | English | 2020 | 2020-07 | 10.3904/kjim.2019.312 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Clinical impact of anti-thymocyte globulin on survival and graft-versus-host disease in patients undergoing human leukocyte antigen mismatched allogeneic stem cell transplantation | Background/Aims: Rabbit anti-thymocyte globulin (ATG) is usually incorporated in hematopoietic stem cell transplantation (HSCT) to reduce the incidence of graft-versus-host disease (GVHD). This study aimed to find optimal ATG doses in patients undergoing human leukocyte antigen (HLA)-mismatched allogeneic HSCT. Methods: We retrospectively collected medical records from 352 consecutive patients with acute myeloid leukemia (n = 214), acute lymphoblastic leukemia (n = 62), or myelodysplastic syndrome (n = 76) in eight centers of Korea between 2005 and 2015. All patients received busulfan-based conditioning without total body irradiation (TBI) and received stem cells from HLA-mismatched donors. Results: In the current study, 5-year overall survival rates of patients receiving low to medium doses of ATG (2.5 to 7.5 mg/kg) were higher than those receiving other doses of ATG (hazard ratio [HR], 0.528; 95% confidence interval [CI], 0.311 to 0.897; p = 0.018). The incidence rates of extensive chronic GVHD (ecGVHD) after administration of low to medium doses of ATG were lower than those after other doses of ATG (HR, 0.447; 95% CI, 0.224 ton 0.889; p = 0.022). Conclusions: The low to medium doses of ATG may be associated with improving survival outcomes and reducing incidence of ecGVHD without enhancing the chances of relapse in patients with acute leukemia or myelodysplastic syndrome undergoing non-TBI-based HLA-mismatched allogeneic HSCT. | Kim, Taeyun; Choi, Yunsuk; Lee, Je-Hwan; Park, Silvia; Ahn, Jae-Sook; Moon, Joon-Ho; Shin, Ho-Jin; Lee, Won Sik; Kim, Dajung; Lee, Ho Sup | Kosin Univ, Gospel Hosp, Dept Internal Med, 262 Gamcheon Ro, Busan 49267, South Korea; Univ Ulsan, Ulsan Univ Hosp, Coll Med, Dept Hematol & Oncol, Ulsan, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Hematol, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Div Hematol Oncol, Seoul, South Korea; Chonnam Natl Univ, Hwasun Hosp, Dept Internal Med, Hwasun, South Korea; Kyungpook Natl Univ Hosp, Dept Hematol, Daegu, South Korea; Pusan Natl Univ Hosp, Dept Internal Med, Busan, South Korea; Inje Univ, Busan Paik Hosp, Dept Internal Med, Busan, South Korea | Kim, Taeyun/AAL-3477-2021; Lee, Jae-Hyun/ABE-3803-2020 | 57213164256; 35200292800; 16637544900; 36182573400; 22984055900; 56568642700; 16239868400; 55556573100; 57195951981; 57218103550 | hs52silver@gmail.com; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 35 | 2 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.884 | 35.6 | 0.13 | 2025-06-25 | 2 | 3 | Antithymocyte globulin; Graft vs host disease; Survival; Human leukocyte antigen mismatch; Allogeneic hematopoietic stem cell transplantation | ANTITHYMOCYTE GLOBULIN; RANDOMIZED-TRIAL; DONOR; PROPHYLAXIS; PREVENTION; LEUKEMIA; ATG; THYMOGLOBULIN; DEPLETION; STANDARD | Allogeneic hematopoietic stem cell transplantation; Antithymocyte globulin; Graft vs host disease; Human leukocyte antigen mismatch; Survival | Antilymphocyte Serum; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; HLA Antigens; Humans; Republic of Korea; Retrospective Studies; Transplantation Conditioning; busulfan; leukocyte antigen; thymocyte antibody; HLA antigen; lymphocyte antibody; acute lymphoblastic leukemia; acute myeloid leukemia; adolescent; adult; aged; allogeneic stem cell transplantation; Article; chronic graft versus host disease; disease association; dose response; drug effect; drug megadose; female; graft versus host reaction; hazard ratio; human; low drug dose; major clinical study; male; mismatched unrelated donor; myelodysplastic syndrome; overall survival; retrospective study; survival rate; survival time; treatment planning; adverse event; graft versus host reaction; hematopoietic stem cell transplantation; South Korea; transplantation conditioning | English | 2020 | 2020-03 | 10.3904/kjim.2018.317 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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