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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
Editorial Material Impacts of the rapid increase in aged patients on implant dentistry Kwon, Tae-Geon Kyungpook Natl Univ, Sch Dent, Dept Oral & Maxillofacial Surg, 2177 Dalgubeol Daero, Daegu 700412, South Korea 35205433300 kwondk@knu.ac.kr; JOURNAL OF THE KOREAN ASSOCIATION OF ORAL AND MAXILLOFACIAL SURGEONS J KOR ASSOC ORAL MAX 2234-7550 2234-5930 51 2 ESCI DENTISTRY, ORAL SURGERY & MEDICINE 2024 1.4 65.1 N/A 0 0 anticoagulant agent; cognitive defect; demographics; dental procedure; dentistry; developed country; Editorial; human; hypertension; life expectancy; long term care; medical care; mortality rate; mouth hygiene; osteolysis; osteoporosis; systemic disease English 2025 2025-04 10.5125/jkaoms.2025.51.2.71 바로가기 바로가기 바로가기 바로가기
Article Concentration Dependence Orange Light Generation Through Sm³⁺-Doped Soda Lime Alumino Borate Glasses for Orange Laser Medium Material The melt-quenching technique is used to fabricate calcium sodium aluminum borate glasses (Sm: ANCB) doped with varying concentrations of Sm3+ ions. Characteristics of ANCBSm glasses, including density, molar volume, refractive index, absorption, emission (via visible light, X-ray, and proton excitation), decay time, and CIE color coordinates, are analyzed. The density, molar volume, and refractive index of ANCBSm glass increased with Sm2O3 concentration. Sm3+ ions enabled photon absorption in both visible and NIR regions, with a strong reddish-orange emission at 600 nm due to the H-6(5/2) -> P-6(3/2) transition under various excitations. X-ray excitation is also compared with BGO scintillation crystals. The J-O theory predicted the radiative properties of Sm3+ ion emission levels. Decay curves of the H-6(5/2) levels showed a single exponential nature with a millisecond-order lifetime. CIE chromaticity of ANCBSm glasses is in the reddish-orange region. ANCBSm glasses have potential applications in orange laser medium material. Jarucha, Nawarut; Ruangtaweep, Yotsakit; Meejitpaisan, Piyachat; Kim, Hong Joo; Boontueng, Phongnared; Kobdaj, Chinorat; Ritjoho, Narongrit; Sanghangthum, Taweap; Valiev, Damir; Kaewkhao, Jakrapong Nakhon Pathom Rajabhat Univ, Fac Sci & Technol, Phys Program, Nakhon Pathom 73000, Thailand; Nakhon Pathom Rajabhat Univ, Ctr Excellence Glass Technol & Mat Sci CEGM, Nakhon Pathom 73000, Thailand; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Ubon Ratchathani Univ UBU, Fac Sci, Dept Phys, Ubon Ratchathani 34190, Thailand; Suranaree Univ Technol SUT, Sch Phys, Nakhon Ratchasima 30000, Thailand; Chulalongkorn Univ CU, Fac Med, Dept Radiol, Div Radiat Oncol, Bangkok 10330, Thailand; Natl Res Tomsk Polytech Univ, Lenin Ave 30, Tomsk 634050, Russia ; Kobdaj, Chinorat/AAR-6293-2020; Meejitpaisan, Piyachat/HSG-3266-2023; Valiev, Damir/E-4822-2018; Kim, Hong Joo/AAE-1178-2022; Sanghangthum, Taweap/HSI-2073-2023 57219215647; 37108588700; 56006076500; 59051568100; 59182608000; 57194221209; 57204908345; 15725955100; 57219779206; 23974520300 djone@webmail.npru.ac.th; PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE PHYS STATUS SOLIDI A 1862-6300 1862-6319 222 12 SCIE MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER 2024 1.9 65.2 0 2025-05-07 0 1 BGO; borate glasses; luminescence; samarium; scintillator SM3+ IONS; SPECTROSCOPIC PROPERTIES BGO; borate glasses; luminescence; samarium; scintillator Citrus fruits; Glass; Ions; Lime; Refractive index; Samarium; Volume measurement; Alumino-borate; BGO; Borate glass; Concentration dependence; Laser medium; Light generation; Medium material; Melt quenching techniques; Soda lime; X-ray excitation; Samarium compounds English 2025 2025-06 10.1002/pssa.202400174 바로가기 바로가기 바로가기 바로가기
Article Light field phase restoration based on the stochastic gradient descent algorithm for expanding the image reconstruction depth range of a computer-generated hologram In this paper, we propose a novel, to our knowledge, light field phase restoration method. The proposed method consists of obtaining the light field from multiple depth planes constituting a three-dimensional object and applying a stochastic gradient descent algorithm to the depth transformation process between them. The light field can be converted into computer-generated holograms by Fourier transforming each orthographic view image and rearranging them in the angular spectrum domain. In this process, computer-generated holograms converted from a light field multiplied with random phase information can reconstruct an aliasing-free image only in a narrow depth range near the light field acquisition plane. In contrast, the phase information restored by the proposed method overcomes this limitation and reconstructs high-quality images in an extended depth range. The light field with restored phase information reconstructs an image with a peak signal-to-noise ratio value improved by approximately 27.27% at a depth plane 10 cm away from the light field focal plane, compared to the case with random phase information. This paper presents an efficient approach to restore light field phase information using the proposed method and the image reconstruction results obtained through simulation and experiment. (c) 2025 Optica Publishing Group. All rights, including for text and data mining (TDM), Artificial Intelligence (AI) training, and similar technologies, are reserved. Bae, Young-Gyu; Lee, Seung-Yeol Kyungpook Natl Univ, Sch Elect & Elect Engn, 80 Daehak Ro, Daegu 41566, South Korea 57204432013; 55881869300 seungyeol@knu.ac.kr; APPLIED OPTICS APPL OPTICS 1559-128X 2155-3165 64 13 SCIE OPTICS 2024 1.7 66.0 N/A 0 0 REAL-TIME; ANGULAR SPECTRUM; NEURAL-NETWORK; DIFFRACTION 3D reconstruction; Computer generated holography; Fourier transforms; Computergenerated holograms (CGH); Depth range; Images reconstruction; Light fields; Phase information; Random-phase; Restoration methods; Stochastic gradient descent algorithm; Three-dimensional object; Transformation process; Image enhancement English 2025 2025-05-01 10.1364/ao.559459 바로가기 바로가기 바로가기 바로가기
Article Multilevel analysis of individual, household, and community factors influencing COVID-19 vaccination intention: evidence from the 2021 Korea Community Health Survey Objectives: This study aimed to investigate the combined effects of individual, household, and community-level factors on coronavirus disease 2019 (COVID-19) vaccination intention using a multilevel analysis. Methods: This cross-sectional study analyzed raw data from the 2021 Korea Community Health Survey and regional statistics from 255 health centers, with a final sample of 229,216 individuals. Multilevel analysis was conducted, focusing on individual, household, and community-level factors. Individual-level factors included demographics, health status, and COVID-19 concerns; household-level factors included income and marital status; and community-level factors included city type and vaccination rates. Results: At the individual level, significant differences were observed across all variables. At the household level, higher vaccination intention was associated with households of 4 or more members and a monthly income of 4 million Korean won or more. At the community level, higher flu vaccination rates, greater concern about COVID-19 infection, and higher COVID-19 vaccination rates were linked to increased vaccination intention. Conclusion: This study highlights that COVID-19 vaccination intention is influenced by factors at the individual, household, and community levels. Vaccination strategies that integrate household and community-level approaches may be more effective. Policymakers should consider both individual and social health factors when designing vaccination policies. Seong, Ji-seon; Kim, Jong-Yeon Daegu Metropolitan City Hall, Div Infect Dis Control, Daegu, South Korea; Kyungpook Natl Univ, Coll Nursing, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Publ Hlth, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Prevent Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea 58483297100; 58382951500 kom824@knu.ac.kr; OSONG PUBLIC HEALTH AND RESEARCH PERSPECTIVES OSONG PUBLIC HEALTH 2210-9099 2233-6052 16 2 ESCI PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH 2024 1.6 66.0 N/A 0 0 COVID-19; Intention; Multilevel analysis; Vaccination TRUST; SARS COVID-19; Intention; Multilevel analysis; Vaccination SARS-CoV-2 vaccine; adult; aged; Article; community care; coronavirus disease 2019; cross-sectional study; demographics; emergency response time; female; health status; health survey; household; household income; human; human experiment; Korea; major clinical study; male; marriage; medical information; multilevel analysis; public health; social distancing; South Korea; statistics; vaccination English 2025 2025-04 10.24171/j.phrp.2024.0254 바로가기 바로가기 바로가기 바로가기
Article Single-center, retrospective, evaluator-blinded, pilot and pivotal clinical trials: Assessing the mirCaP Kit (hsv2-miR-H9/hsa-miR-3659) as a diagnostic marker for prostate cancer in patients with PSA levels in the gray zone Prostate-specific antigen (PSA) remains a key biomarker for the diagnosis and monitoring of prostate cancer (PCa). For patients within the 'PSA gray zone', the positive predictive value (PPV) of PSA for PCa detection by biopsy is estimated to be between 30 and 42%. In the present study, a single-center, retrospective, evaluator-blinded, pilot and pivotal clinical trial was performed to assess the clinical performance of the mirCaP kit (Urotech, Inc.), which measures the herpes simplex virus 2-microRNA (miR)-H9/hsa-miR-3659 ratio, with respect to helping physicians make appropriate decisions regarding further assessment of patients with PSA levels within this gray zone. For the patients in the initial clinical trial group who were in the PSA gray zone, the sensitivity, specificity, accuracy, PPV and negative predictive value (NPV) of the mirCaP kit were 94.29, 77.50, 85.33, 78.57 and 93.94%, respectively. For those in the pivotal clinical trial, these values were 94.50, 82.73, 87.90, 81.10 and 95.04%, respectively. These results suggest that the mirCaP kit may be an effective non-invasive diagnostic marker for PCa in patients with PSA levels in the gray zone. Thus, the mirCaP kit is a promising tool that can help physicians make a decision regarding the need for prostate biopsy in these patients. Of note, the NPV of >90% indicates that the mirCaP kit could prevent unnecessary prostate biopsies in >90% of these cases. Kim, Won Tae; Kim, Kyeong; Kang, Ho Won; Byun, Young Joon; Piao, Xuan-Mei; Kim, Yong-June; Lee, Sang Cheol; Yun, Seok Joong; Ha, Yun-Sok; Kim, Jiyeon; Kim, Isaac Yi Chungbuk Natl Univ, Coll Med, Dept Urol, 1 Chungdae Ro, Cheongju 28644, Chungbuk, South Korea; Chungbuk Natl Univ Hosp, Dept Urol, Cheongju 28644, Chungbuk, South Korea; Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu 41404, North Gyeongsan, South Korea; Yale Sch Med, Dept Urol, New Haven, CT 06510 USA Piao, Xuan-Mei/ABI-6955-2020; Kim, Yong-June/E-5622-2012 57203514393; 57220864860; 35757703900; 57188656800; 57188653344; 26422204800; 57218216917; 16302421300; 35487226400; 57207437004; 7404143831 wtkimuro@chungbuk.ac.kr; ONCOLOGY LETTERS ONCOL LETT 1792-1074 1792-1082 29 1 SCIE ONCOLOGY 2024 2.2 66.1 0 2025-05-07 0 0 prostatic neoplasms; biomarkers; microRNAs; urine; diagnosis ANTIGEN; MICRORNAS; URINE; BIOMARKER; MEN; RNA biomarkers; diagnosis; microRNAs; prostatic neoplasms; urine microRNA; prostate specific antigen; accuracy; adenocarcinoma; area under the curve; Article; bladder cancer; circulating tumor cell; controlled study; Herpes simplex virus 2; histology; human; human tissue; liquid biopsy; major clinical study; nephrectomy; pilot study; predictive value; prostate biopsy; prostate cancer; prostate hypertrophy; real time polymerase chain reaction; receiver operating characteristic; renal cell carcinoma; retrospective study; reverse transcription polymerase chain reaction; sensitivity and specificity; transitional cell carcinoma; transurethral resection; upregulation; urinary tract infection English 2025 2025-01 10.3892/ol.2024.14770 바로가기 바로가기 바로가기 바로가기
Article Phylogenetic Analysis Based on Whole Genome Sequences, Antibiotic Resistance, and Virulence of Salmonella enterica Clinical Isolates from South Korea Salmonella is a major cause of foodborne disease and frequently causes human salmonellosis in South Korea. In this study, we investigated the genome diversity, antimicrobial resistance, and virulence of clinical isolates of Salmonella enterica from South Korea. We collected 42 S. enterica subsp. enterica isolates from two hospitals in South Korea. Whole genome sequences were determined. Serovars and sequence types (STs) based on multilocus sequence typing (MLST) were identified from whole genome sequences. Phylogenetic trees based on whole genome sequences and a minimum spanning tree based on MLST were constructed. Human serum resistance assays and gentamicin protection assays were performed to assess in vitro virulence. Nineteen serovars were identified among 42 clinical isolates, including nine Salmonella Typhi isolates. There were inconsistencies between serogroups and phylogenetic clusters in the phylogenetic tree and minimum spanning tree, but high clonality of S. Typhi was observed. Salmonella Typhi isolates were divided into two clusters, corresponding to ST1 and ST2. Isolates of serovars Typhimurium and I4,[5],12:i:- clustered into a group, and a hybrid isolate between the two serovars was identified. Four ciprofloxacin-resistant isolates were identified among nine S. Typhi isolates, and all isolates of S. Enteritidis and S. Panama were resistant to colistin. The gentamicin protection assay revealed that serogroup D1 was significantly less virulent than the other serogroups. Our study suggests high diversity of S. enterica clinical isolates from South Korea and non-monophyly of serogroups. In addition, subgroups of S. Typhi isolates and a hybrid isolate between serovars Typhimurium and I4,[5],12:i:- were identified. Choi, Jihyun; Shin, Jong Hyun; Park, Suyeon; Choi, Ji Young; Baek, Jin Yang; Huh, Kyungmin; Chung, Doo Ryeon; Kwon, Ki Tae; Seo, Mi-Ran; Jung, Seung-Hyun; Chung, Yeun-Jun; Ko, Kwan Soo Sungkyunkwan Univ, Sch Med, Dept Microbiol, 300 Chunchun Dong, Suwon 16419, South Korea; Asia Pacific Fdn Infect Dis APFID, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Infect Dis, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; ConnectaGen, Hanam, South Korea; Catholic Univ Korea, Coll Med, Dept Biochem, Seoul, South Korea; Catholic Univ Korea, Coll Med, Dept Microbiol, Seoul, South Korea Baek, Jin Yang/JXO-3331-2024; Kim, Hanjin/KYP-2633-2024; Chung, Doo/A-6672-2011 58751763600; 58076442600; 57219359798; 55722472200; 59966315500; 55569009500; 59674802800; 59660097500; 55915514100; 56539109200; 59720004400; 7202689224 ksko@skku.edu; FOODBORNE PATHOGENS AND DISEASE FOODBORNE PATHOG DIS 1535-3141 1556-7125 22 6 SCIE FOOD SCIENCE & TECHNOLOGY 2024 1.9 66.6 0 0 Salmonella; whole genome; virulence; antibiotic resistance ALGORITHM; TYPHI antibiotic resistance; Salmonella; virulence; whole genome English 2025 2025-06-01 10.1089/fpd.2024.0020 바로가기 바로가기 바로가기 바로가기
Article Synthesis, structural characterization, and luminescence properties of zinc(II) coordination polymers containing bis(4-pyridyl)benzylamine Two new zinc(II) coordination polymers [Zn(bpba)2(NO3)2]n (1) and [Zn(bpba)(SO4)]n center dot 2nH2O center dot nDMF (2) were successfully synthesized by reacting zinc(II) ions with bis(4-pyridyl)benzylamine (bpba) containing different counter anions (NO3- and SO42-). The resulting polymers were fully characterized using various experimental techniques: single-crystal X-ray diffraction analysis, elemental analysis, infrared spectra, ultraviolet/visible spectra, and thermogravimetric analysis. Single-crystal X-ray analyses revealed that the zinc(II) ions in 1 and 2 are tetra-coordinated and adopt a distorted tetrahedral geometry. Polymer 1 exhibits a one-dimensional helical chain structure, which extends into two-dimensional supramolecular networks through hydrogen bonding and C-H center dot center dot center dot pi interactions. Polymer 2 adopts a three-dimensional network structure resulting from the coordination of zinc(II) and sulfate ions as well as bpba ligands. An investigation of the solid-state photoluminescence properties of the polymers at room temperature revealed that their emissions were redshifted compared with those of the free ligand, which is attributed to metal-perturbed intra-ligand charge transfer. Ullah, Ihsan; Le, Ngoc Tram Anh; Min, Kil Sik Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Chem Educ, Daegu 41566, South Korea; Kyungpook Natl Univ, Sci Educ Res Inst, Daegu 41566, South Korea Le, Thien/IVU-7983-2023 58829713600; 58793817000; 7201466885 minks@knu.ac.kr; JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY J INCL PHENOM MACRO 1388-3127 1573-1111 105 3-4 SCIE CHEMISTRY, MULTIDISCIPLINARY 2024 1.6 66.7 0 2025-05-07 0 0 Coordination polymer; Zinc(II) ion; Polypyridine ligand; Crystal structure; Photoluminescence METAL-ORGANIC FRAMEWORKS; CRYSTAL-STRUCTURES; LIGAND; DIVERSITY; SERIES; PHOTOLUMINESCENCE; ADSORPTION; ACID; CO Coordination polymer; Crystal structure; Photoluminescence; Polypyridine ligand; Zinc(II) ion Elastomers; Thermogravimetric analysis; X ray diffraction analysis; Zinc compounds; Benzylamines; Coordination Polymers; Coordination-polymers; Crystals structures; Luminescence properties; Polypyridine ligands; Pyridyl; Structural characterization; Synthesised; Zinc(II) ion; Ligands English 2025 2025-04 10.1007/s10847-025-01275-3 바로가기 바로가기 바로가기 바로가기
Article A review of site selection criteria and investigation factors for HLW disposal: insights from leading countries and proposals for Korea The safe management and long-term disposal of high-level radioactive waste are crucial for safeguarding humanity and the environment from radioactive hazards and are regarded as a significant challenge for the global nuclear industry. This paper analyzes site selection criteria related to geological investigations in the cases of Sweden, Finland, Switzerland and France, which have either selected or proposed deep geological disposal sites. It reviews the investigation parameters and methods defined according to these criteria and comprehensively analyzes the rationale and importance behind deriving these parameters. Based on the analysis of international cases related to geological site selection criteria and evaluation factors, this paper proposes geological performance verification factors and items tailored to the geological characteristics of Korea. The geological performance factors of the natural barrier are categorized into nine detailed fields: rock and mineralogy, faults and discontinuities, seismicity, Quaternary geology, hydrogeology, hydrochemistry, thermal properties and rock mechanics. These factors are suggested by reflecting the geological characteristics of Korea, grounded in the case studies of leading countries in disposal research and the background and rationale for each verification item are described. Na, Taeyoo; Chae, Byung-Gon; Kim, Min-Jun; Park, Eui-Seob; Nahm, Wook-Hyun; Hyun, Sung Pil; Choi, Junghae Korea Inst Geosci & Mineral Resources, Geol & Space Div, Daejeon 34132, South Korea; Korea Inst Geosci & Mineral Resources, Climate Change Response Div, Daejeon 34132, South Korea; Kyungpook Natl Univ, Dept Earth Sci Educ, Daegu 41566, South Korea Park, Eui Seob/JMB-7816-2023 57204570724; 35782715300; 59954841800; 25646193400; 9334391900; 58895840700; 59819720600 bgchae@kigam.re.kr; GEOSCIENCES JOURNAL GEOSCI J 1226-4806 1598-7477 29 3 SCIE GEOSCIENCES, MULTIDISCIPLINARY 2024 1.5 66.9 0 2025-05-07 0 0 Deep geological disposal; High-level radioactive waste; Site selection; Criteria; Parameters Criteria; Deep geological disposal; High-level radioactive waste; Parameters; Site selection English 2025 2025-06 10.1007/s12303-025-00029-0 바로가기 바로가기 바로가기 바로가기
Article Optimization of Airless Tires Composed of Fiber/Rubber Composites for High-Speed Vehicles Using ANN and Computational Analyses An artificial neural network is employed to predict the hyper-elastic mechanical properties of glass fiber/rubber composites used for airless tires. The training data are generated through FEA for representative volume elements. All data are split into training, validation, and testing sets in a ratio of 0.7:0.15:0.15. The comparison between FEA and ANN reveals an error margin of approximately 7.0%, indicating good accuracy. Additionally, the sensitivity analysis based on the response surface methodology is conducted to identify critical design variables influencing the shape and thickness of the spoke and tread of airless tires. An innovative airless tire model has been created using key design variables: fiber volume fractions in the spokes and tread, and thicknesses of the upper and lower spoke sections. The goal-attain multi-objective optimization is performed to optimize four stiffness of the tire. To validate the effectiveness of the optimization, a 3D FE tire model is constructed with optimal design parameters and subjected to deformation analyses to compute four types of static tire stiffness. The discrepancies in stiffness between the two methods range from 0.11 to 7.59%. Finally, the optimized model of the tire undergoes dynamic analyses to assess its vibrational performance, resulting in significantly decaying reaction forces. © The Author(s), under exclusive licence to The Korean Society of Automotive Engineers 2025. Lee, Kelvin Hanyong; Choi, Heung Soap; Kim, Cheol Department of Mechanical Engineering, Kyungpook National University, Daegu, 41566, South Korea; Department of Mechanical and Design Engineering, Hongik University, Sejong, 30016, South Korea; Department of Mechanical Engineering, Kyungpook National University, Daegu, 41566, South Korea 59907708500; 55710998000; 55508786300 kimchul@knu.ac.kr; International Journal of Automotive Technology INT J AUTO TECH-KOR 1229-9138 1976-3832 SCIE ENGINEERING, MECHANICAL;TRANSPORTATION SCIENCE & TECHNOLOGY 2024 1.5 66.9 0 2025-06-11 0 Airless tire; Artificial neural network; Goal attain optimization; Response surface methodology; Rubber composites Machine vibrations; Multiobjective optimization; Sensitivity analysis; Airless tires; Design variables; Fiber-rubber composites; Goal attain optimization; High speed vehicles; Neural-networks; Optimisations; Response-surface methodology; Rubber composite; Tire models; Vibration analysis English Article in press 2025 10.1007/s12239-025-00265-1 바로가기 바로가기 바로가기
Article Properties of blown composite films of polypropylene/calcium carbonate and polypropylene/calcium oxide Extrusion molding and inflation are employed on a pilot scale to fabricate two types of composite films intended for pouch applications (flexible enclosures designed to encase and protect, e.g., lithium-ion battery components). The first type comprises cast polypropylene (CPP) blended with calcium carbonate (CaCO3) at concentrations of 2.5-5 wt%. In contrast, the second type incorporates CPP with calcium oxide (CaO) at similar concentrations. The presence of CPP, CaCO3, and CaO is confirmed through x-ray diffraction analysis, while Fourier-transform infrared spectroscopy validates the formation of CPP/CaCO3 (2.5-5 wt%) and CPP/CaO (2.5-5 wt%) composite films. Both the melting and crystallization behaviors of these composite films are analyzed using differential scanning calorimetry. Thermogravimetric analysis confirms that the prepared composites feature enhance thermal stability compared to the pure CPP film. Furthermore, the results demonstrate that surface morphology is affected by both the varying contents of CaCO3 and CaO. Among the composites, CPP/CaCO3 at 2.5 wt% and CPP/CaO at 5 wt% exhibit improved mechanical properties, indicating that they act as effective compatibilizers. In addition, for the CaCO3 and CaO particles, the draw ratio increases with higher concentrations (5 wt%), likely due to particle concentration effects on film drawing. The water-vapor transmission rate in CPP/CaCO3 (2.5-5 wt%) and CPP/CaO (2.5-5 wt%) composite films decreased compared to the pure CPP film, which can be attributed to increased tortuosity. Our results highlight a promising pathway for developing composite films into advanced materials, particularly as flexible enclosures for protecting and housing lithium-ion battery components in cell pouch applications. Lim, Chun Sam; Kim, Mi Kyung; Kim, Tae Young; Lee, Jungeon; Jung, Jae Hoon; Kim, Youngkwon; Yeasmin, Sabina; Yang, Seong Baek; Kwon, Dong-Jun; Yeum, Jeong Hyun KS Fine Chem Co Ltd, Daegu 43020, South Korea; Kyungpook Natl Univ, Dept Biofibers & Biomat Sci, Daegu 41566, South Korea; DYETEC Inst, Ind Mat R&D Grp, Daegu 41706, South Korea; Gyeongsang Natl Univ, Res Inst Green Energy Convergence Technol, Jinju 52828, South Korea; Gyeongsang Natl Univ, Dept Mat Sci & Convergence Technol, Jinju 52828, South Korea 59898353200; 59500566900; 57208461628; 57559595700; 58476748000; 59899145600; 57216565706; 59897741600; 36550312000; 6602257098 sbyang@gnu.ac.kr; jhyeum@knu.ac.kr; MATERIALS RESEARCH EXPRESS MATER RES EXPRESS 2053-1591 12 5 SCIE MATERIALS SCIENCE, MULTIDISCIPLINARY 2024 2.2 67.1 0 2025-06-11 0 0 cast polypropylene; calcium carbonate; calcium oxide; composite film FTIR calcium carbonate; calcium oxide; cast polypropylene; composite film Lithium-ion batteries; Oxide films; Thermogravimetric analysis; X ray powder diffraction; Calcium carbonate CaCO; Cast polypropylene; Cast polypropylene films; Diffraction analysis; Fourier transform infrared; Ion batteries; Lithium ions; Pilot scale; Property; Transform infrared spectroscopy; Fourier transform infrared spectroscopy English 2025 2025-05-01 10.1088/2053-1591/adcf12 바로가기 바로가기 바로가기 바로가기
Article Selective Determination of Nicotinamide Adenine Dinucleotide (NADH) on Screen-Printed Polyethylene Terephthalate (PET) Electrodes Modified with a Reduced Graphene Oxide (rGO), Gold Nanoparticle (AuNP), and Poly-Methylene Blue Nanocomposite The present work reports the development of a disposable nanocomposite-based amperometric sensor for reduced nicotinamide adenine dinucleotide (NADH). To fabricate disposable electrodes, conductive carbon and silver ink were screen-printed on a polyethylene terephthalate (PET) film substrate. The surface of the working electrode was modified with gold nanoparticles (AuNPs) decorated reduced graphene oxide (rGO) and subsequently electro-polymerized with methylene blue for the determination of NADH. The nanocomposite modified electrode decreases the potential for NADH oxidation with a significant increase in the current due to the synergy between AuNP and rGO. The developed electrochemical sensor determined NADH at 0 V versus pseudo-Ag/AgCl with linear relationships from 25 mu mol L-1 to 1.0 mmol L-1 and 1.0 mmol L-1 to 10 mmol L-1. The sensor exhibits a good sensitivity of 35.49 mu A/mmol L-1/cm2 and a detection limit of 6.61 mu mol L-1 based upon a signal-to-noise ratio of 3. Furthermore, interferences from electroactive substances such as ascorbic acid and uric acid are eliminated at an oxidation potential of 0 V. Thus, the modified electrode provides a simple, selective, disposable, and low-cost approach for the amperometric determination of NADH. Santhosh, Mallesh; Park, Tusan Kyungpook Natl Univ, Smart Agr Innovat Ctr, Daegu, South Korea; Kyungpook Natl Univ, Dept Smart Bioind Mech Engn, Daegu, South Korea ; Park, Tusan/C-2057-2012 56533710200; 57202780408 tusan.park@knu.ac.kr; ANALYTICAL LETTERS ANAL LETT 0003-2719 1532-236X 58 7 SCIE CHEMISTRY, ANALYTICAL 2024 1.8 67.1 0 2025-05-07 0 0 Polyethylene terephthalate (PET) electrode; nicotinamide adenine dinucleotide (NADH); reduced graphene oxide (rGO); electrochemical analysis CARBON ELECTRODE; OXIDATION; NAD(+) electrochemical analysis; nicotinamide adenine dinucleotide (NADH); Polyethylene terephthalate (PET) electrode; reduced graphene oxide (rGO) English 2025 2025-05-03 10.1080/00032719.2024.2356247 바로가기 바로가기 바로가기 바로가기
Article Crystal structures of cystathionine (3-lyase and cystathionine (3-lyase like protein from Bacillus cereus ATCC 14579 Cystathionine (3-lyase (CBL) and cystathionine (3-lyase-like protein (CBLP) are key PLP-dependent enzymes involved in methionine biosynthesis. In Bacillus cereus ATCC 14579 CBL (BcCBL) and CBLP (BcCBLP) catalyze the conversion of cystathionine to homocysteine and pyruvate. In this study, we found that both Bc CBL and Bc CBLP effectively catalyze cystathionine cleavage, with Bc CBLP exhibiting a higher catalytic efficiency (kcat) and low substrate affinity (Km). We determined their crystal structures in complex with pyridoxal phosphate (PLP). Bc CBL, forming a tetramer, aligns with typical CBLs in sulfur amino acid metabolism, while Bc CBLP, forming a dimer, resembles the bifunctional MalY enzyme from Escherichia coli, indicating potential additional regulatory roles. These structural and functional insights highlight the distinct roles of Bc CBL and Bc CBLP in cellular metabolism. This study provides valuable insights into the structural diversity and potential functions of these enzymes, contributing to the broader knowledge of PLP-dependent enzymatic mechanisms. Lee, Seul Hoo; Yu, Hyeonjeong; Hong, Jiyeon; Seok, Jihye; Kim, Kyung-Jin Kyungpook Natl Univ, KNU Inst Microorganisms, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Life Sci, FOUR KNU Creat BioRes Grp BK21, Daegu 41566, South Korea Kim, Kyung-Jin/MVY-3405-2025 57205261937; 58260376000; 57205354591; 57216545714; 55510867400 kkim@knu.ac.kr; BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS BIOCHEM BIOPH RES CO 0006-291X 1090-2104 742 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOPHYSICS 2024 2.2 67.7 0 2025-05-07 0 0 Cystathionine (3-lyase (CBL); Cystathionine (3-lyase like protein (CBLP); Bacillus cereus ATCC 14579; PLP dependent enzymes C-S LYASE; BETA-LYASE; METHIONINE; BIOSYNTHESIS; PURIFICATION; ENZYMES; PATHWAYS; SYNTHASE; PLANTS; SUBSP Bacillus cereus ATCC 14579; Cystathionine β-lyase (CBL); Cystathionine β-lyase like protein (CBLP); PLP dependent enzymes Amino Acid Sequence; Bacillus cereus; Bacterial Proteins; Crystallography, X-Ray; Cystathionine; Lyases; Models, Molecular; Protein Conformation; Pyridoxal Phosphate; cystathionine beta lyase; cystathionine beta lyase like protein; genomic DNA; homocysteine; protein; pyridoxal 5 phosphate; pyruvic acid derivative; unclassified drug; bacterial protein; cystathionine; cystathionine beta-lyase; lyase; pyridoxal 5 phosphate; amino acid metabolism; amino acid sequence; Article; Bacillus cereus; bacillus cereus ATCC 14579; bioinformatics; biosynthesis; cell metabolism; crystal structure; crystallization; data processing; differential scanning fluorimetry; enzyme activity; enzyme kinetics; Escherichia coli; fluorometry; maximum likelihood method; molecular docking; nonhuman; phylogenetic tree; protein structure; real time polymerase chain reaction; thermostability; X ray diffraction; chemistry; enzymology; genetics; metabolism; molecular model; protein conformation; X ray crystallography English 2025 2025-01 10.1016/j.bbrc.2024.151122 바로가기 바로가기 바로가기 바로가기
Article Fulvic acid inhibits the differentiation of 3T3-L1 adipocytes by activating the Ca2+/CaMKII/AMPK pathway Type 2 diabetes increases the risk of developing obesity. Although fulvic acid alleviates back fat thickness in pigs, the mechanism underlying its anti-obesity effect remains unclear. Therefore, we investigated the anti-obesity mechanism of fulvic acid using 3T3-L1 adipocytes. We examined the effects of fulvic acid on adipocyte differentiation, cell viability, and lipid accumulation using molecular techniques. Fulvic acid treatment significantly decreased intracellular lipid accumulation in 3T3-L1 cells during the differentiation compared with that in the control group. Western blotting revealed fulvic acid-induced downregulated expression of the adipocyte differentiation-related markers peroxisome proliferator-activated receptor gamma, CCAAT/enhancer-binding protein alpha, and sterol regulatory element-binding protein 1. The fulvic acid treatment decreased the expression of the lipid uptake-related markers fatty acid-binding protein 4 and the cluster of differentiation 36 in 3T3-L1 cells. Moreover, fulvic acid significantly increased cytosolic Ca2+ concentration via Ca2+ sequestration from the endoplasmic reticulum, enhanced Ca2+/calmodulin-dependent protein kinase II (CaMKII) activity, and upregulated AMP-activated protein kinase (AMPK), thereby reducing adipocyte differentiation. Conclusively, fulvic acid attenuates adipocyte differentiation by activating the Ca2+/CaMKII/AMPK pathway, suggesting its anti-obesity potential. Ju, Hyeon Yeong; Song, Seung-Eun; Shin, Su-Kyung; Jeong, Gil-Saeng; Cho, Ho-Chan; Im, Seung-Soon; Song, Dae-Kyu Keimyung Univ, Obes Mediated Dis Res Ctr, Dept Physiol, Sch Med, 1095 Dalgubeoldae Ro, Daegu 42601, South Korea; Kyungpook Natl Univ, Dept Food Sci & Nutr, 80 Daehak Ro, Daegu 41566, South Korea; Chungnam Natl Univ, Coll Pharm, 99 Daehak Ro, Daejeon 34134, South Korea; Keimyung Univ, Dept Endocrinol, Internal Med, Sch Med, 1095 Dalgubeoldae Ro, Daegu 42601, South Korea 58685070700; 36574341400; 23988149900; 57204396456; 20336747500; 57211749547; 7402443802 dksong@dsmc.or.kr; BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS BIOCHEM BIOPH RES CO 0006-291X 1090-2104 743 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOPHYSICS 2024 2.2 67.7 0 2025-05-07 0 0 Fulvic acid; CaMKII; AMPK; Obesity; Cytosolic Ca2+ ATTENUATES ADIPOGENESIS; TRANSCRIPTION FACTORS; EXPRESSION; LIPOLYSIS; REDUCTION; LEVEL 3T3-L1 adipocytes; AMPK; CaMKⅡ; Cytosolic Ca<sup>2+</sup>; Fulvic acid; Obesity 3T3-L1 Cells; Adipocytes; Adipogenesis; AMP-Activated Protein Kinases; Animals; Anti-Obesity Agents; Benzopyrans; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Differentiation; Lipid Metabolism; Mice; Signal Transduction; calcium calmodulin dependent protein kinase II; calcium ion; CCAAT enhancer binding protein alpha; CD36 antigen; dexamethasone; fatty acid binding protein 4; fulvic acid; peroxisome proliferator activated receptor gamma; probenecid; rosiglitazone; sterol regulatory element binding protein 1c; thapsigargin; triacylglycerol; antiobesity agent; benzopyran derivative; calcium; calcium calmodulin dependent protein kinase II; hydroxymethylglutaryl coenzyme A reductase kinase; 3T3-L1 cell line; adipocyte; AMPK signaling; area under the curve; Article; cell differentiation; cell viability; cell viability assay; chemoluminescence; controlled study; diagnostic test accuracy study; down regulation; human; human cell; lipid storage; lipolysis; MTT assay; non insulin dependent diabetes mellitus; obesity; protein expression; protein phosphorylation; radioimmunoprecipitation; signal transduction; Western blotting; adipogenesis; animal; cytology; drug effect; lipid metabolism; metabolism; mouse English 2025 2025-01 10.1016/j.bbrc.2024.151173 바로가기 바로가기 바로가기 바로가기
Article Structural comparison of three MoaE proteins in Mycobacterium tuberculosis: Insights into molybdopterin synthase assembly and specificity Molybdoenzymes are essential for the survival and pathogenicity of Mycobacterium tuberculosis and require the molybdenum cofactor (MoCo). The biosynthesis of MoCo involves the molybdopterin (MPT) synthase complex, which is composed of the MoaD and MoaE subunits. The genome of M. tuberculosis encodes three homologs of MoaE: MoaE1, MoaE2, and MoaXE (the latter being a MoaE component of a MoaD-MoaE fusion protein known as MoaX), as well as three MoaD proteins. However, the structural basis for their functional specificity and interaction with MoaD partners remains unclear. We determined the crystal structures of all three MoaE proteins, revealing a conserved alpha/beta hammerhead fold with distinct binding interface features resulting from minor sequence variations. Pull-down assays demonstrate that MoaE2 and MoaXE selectively interact with their cognate MoaD partners, while MoaE1 exhibits promiscuous binding to all MoaD forms. Although the structural plasticity of MoaE1 enables binding to three MoaD forms, it suggests that not all MoaE-MoaD combinations yield functional MPT synthase complexes, as structural rearrangements can lead to enzymatic inactivation. Our findings provide detailed insights into the molecular determinants that govern the assembly and specificity of MPT synthase in M. tuberculosis. Cho, Hyo Je; Yang, Seung Hyeon; Lee, Hyun-Shik; Kang, Beom Sik Chungbuk Natl Univ, Dept Biol Sci & Biotechnol, Cheongju 28644, South Korea; Kyungpook Natl Univ, Sch Life Sci & Biotechnol, Daegu 41566, South Korea 36742238400; 59781770800; 59559104200; 59682606700 hyojec@cbnu.ac.kr; bskang2@knu.ac.kr; BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS BIOCHEM BIOPH RES CO 0006-291X 1090-2104 768 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOPHYSICS 2024 2.2 67.7 N/A 0 0 Mycobacterium tuberculosis; Molybdopterin synthase; MoaE structural diversity; Molybdenum cofactor biosynthesis; Protein-protein interaction BIOSYNTHESIS; MECHANISM; ENZYMES MoaE structural diversity; Molybdenum cofactor biosynthesis; Molybdopterin synthase; Mycobacterium tuberculosis; Protein-protein interaction Amino Acid Sequence; Bacterial Proteins; Binding Sites; Coenzymes; Crystallography, X-Ray; Metalloproteins; Models, Molecular; Molybdenum Cofactors; Mycobacterium tuberculosis; Protein Binding; Protein Conformation; Pteridines; Substrate Specificity; Sulfurtransferases; molybdopterin; molybdopterin synthase; unclassified drug; bacterial protein; coenzyme; metalloprotein; molybdenum cofactor; molybdopterin; molybdopterin synthase; protein binding; pteridine derivative; sulfurtransferase; affinity chromatography; Article; bioinformatics; biosynthesis; crystal structure; Escherichia coli; mass spectrometry; molecular docking; molecular dynamics; mutagenesis; Mycobacterium tuberculosis; nonhuman; pathogenicity; phenotype; polyacrylamide gel electrophoresis; protein assembly; protein expression; protein protein interaction; protein purification; protein structure; size exclusion chromatography; X ray crystallography; X ray diffraction; amino acid sequence; binding site; chemistry; comparative study; enzyme specificity; enzymology; genetics; metabolism; molecular model; protein conformation English 2025 2025-07-01 10.1016/j.bbrc.2025.151945 바로가기 바로가기 바로가기 바로가기
Article TGFBI regulates pulmonary vascular remodeling through endothelial-to-mesenchymal transition in pulmonary arterial hypertension Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by elevated pulmonary artery pressure, right ventricular (RV) hypertrophy, and vascular remodeling. Transforming growth factor-(3-induced protein (TGFBI) is an extracellular matrix protein regulated by TGF-(3 that plays a critical role in pulmonary vascular remodeling in PAH. Here, we investigated the role of TGFBI in monocrotaline-induced PAH pathogenesis and evaluated the therapeutic effects of the endothelin receptor antagonist bosentan. Monocrotaline administration resulted in marked RV hypertrophy and increased medial wall thickness of pulmonary arterioles, accompanied by elevated TGFBI expression in both pulmonary vasculature and serum. Notably, bosentan treatment effectively reversed these pathological changes. In lung tissue, PAH induced upregulation of TGF-(31 and enhanced SMAD2/3 phosphorylation, both of which were normalized by bosentan. While TGFBI expression exhibited variable patterns in the heart, liver, and kidneys, TGF-(3 signaling alterations were predominantly observed in the lungs. Additionally, PAH promoted endothelial-to-mesenchymal transition (EndMT) in lung tissue, as evidenced by decreased expression of endothelial markers (CD31 and VE-cadherin) and increased expression of mesenchymal markers (Endothelin 1, COL1A1, COL3A1, SLUG, and Snail). Bosentan treatment effectively reversed these EndMT-related changes. Collectively, these findings highlight a critical role for TGFBI and TGF-(3 signaling in pulmonary vascular remodeling during PAH development, primarily through modulation of EndMT. This study suggests that targeting TGFBI may represent a promising therapeutic strategy for PAH management. Roh, Da Eun; Park, Na Rae; Choi, Bo Geum; Kang, Youra; Kim, Jung-Eun; Kim, Yeo Hyang Kyungpook Natl Univ, Childrens Hosp, Sch Med, Dept Pediat,Div Pediat Cardiol, 807 Hoguk Ro, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Pediat, Daegu 41944, South Korea; Inje Univ, Busan Paik Hosp, Coll Med, Dept Pediat, Busan 47392, South Korea 57195734230; 24492053700; 57201351496; 59538015400; 57209054588; 57032023800 kimyhmd@knu.ac.kr; BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS BIOCHEM BIOPH RES CO 0006-291X 1090-2104 751 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOPHYSICS 2024 2.2 67.7 0 2025-05-07 0 0 Pulmonary arterial hypertension; TGFBI; Pulmonary vascular remodeling; TGF-(3 signaling; Endothelial-to-mesenchymal transition GENE Endothelial-to-mesenchymal transition; Pulmonary arterial hypertension; Pulmonary vascular remodeling; TGF-β signaling; TGFBI Animals; Bosentan; Epithelial-Mesenchymal Transition; Extracellular Matrix Proteins; Hypertension, Pulmonary; Lung; Male; Mice, Inbred C57BL; Monocrotaline; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Sulfonamides; Transforming Growth Factor beta; Vascular Remodeling; bosentan; cadherin; collagen type 1; collagen type 3; endothelin; endothelin 1; monocrotaline; platelet endothelial cell adhesion molecule 1; Smad2 protein; Smad3 protein; transcription factor Slug; transcription factor Snail; transforming growth factor beta1; vascular endothelial cadherin; betaIG-H3 protein; bosentan; monocrotaline; scleroprotein; sulfonamide; transforming growth factor beta; animal experiment; animal model; animal tissue; arterial pressure; Article; biomechanics; cell proliferation; controlled study; endothelial-mesenchymal transition; enzyme linked immunosorbent assay; extracellular matrix; image analysis; interventricular septum; lung arteriole; lung artery pressure; lung blood vessel; lung parenchyma; male; nonhuman; pathogenesis; protein expression; protein phosphorylation; pulmonary hypertension; pulmonary vascular remodeling; rat; right ventricular hypertrophy; TUNEL assay; upregulation; vascular remodeling; Western blotting; animal; C57BL mouse; drug effect; drug therapy; epithelial mesenchymal transition; lung; metabolism; pathology; pulmonary artery; Sprague Dawley rat; vascularization English 2025 2025-03-05 10.1016/j.bbrc.2025.151435 바로가기 바로가기 바로가기 바로가기
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