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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Highly sensitive voltammetric sensor comprising CuSn(OH)6-multi-walled carbon nanotubes-β-cyclodextrin composites and poly(L-arginine) for indole-3-lactic acid analyses in alcohol use disorder serum samples | A highly sensitive voltammetric sensing platform configured via the drop-casting of composites of CuSn(OH)(6)-multi-walled carbon nanotubes-beta-cyclodextrin (CuSn(OH)(6)-MWCNT-beta CD) on an arginine-electropolymerized screen-printed carbon electrode (CuSn(OH)(6)-MWCNT-beta CD/p-Arg/SPCE) was demonstrated to determine the concentrations of indole-3-lactic acid (ILA) in buffer and serum solutions. Prior to the analysis, the successful assembly of the composites and polymer layers was confirmed using field emission scanning electron microscopy, atomic force microscopy, and X-ray photoelectron spectroscopy. The changes in the current due to the direct oxidation of ILA on the modified electrode were used to quantify the ILA. A dynamic range of 0.05-20 mu M with a limit of detection of 9 nM for ILA under optimal conditions was achieved primarily with the combined use of CuSn(OH)(6), MWCNT, and beta CD, resulting in a large electrochemical active surface area (0.185 cm(2)), low charge transfer resistance (similar to 2 Omega), and fast electron transfer. Furthermore, the sensing performance, including selectivity, sensitivity, reproducibility, repeatability, and stability, for ILA detection was evaluated. Finally, the ILA concentrations in the pooled clinical serum samples of healthy control and alcohol use disorder patients were measured using our method, the results of which exhibited a notable resemblance to those obtained using liquid chromatography with tandem mass spectrometry. | Li, Jingjing; Lee, Sang Hyuk; Lee, Ji Eun; Park, Hyun-Mee; Choi, Bogyoung; Choi, Jung-Seok; Lee, Hye Jin | Kyungpook Natl Univ, Dept Chem, 80 Daehakro, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, 80 Daehakro, Daegu 41566, South Korea; Korea Inst Sci & Technol, Chem & Biol Integrat Res Ctr, Biomed Res Div, Seoul 02792, South Korea; Korea Inst Sci & Technol, Adv Anal & Data Ctr, 5 Hwarang Ro 14-gil, Seoul 02792, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pediat, Seoul 06351, South Korea | ; Lee, Ji-Eun/B-9774-2018; LEE, HYEJIN/W-1345-2018 | 57222707218; 55188583800; 55992294200; 35199912200; 58251390500; 8708904700; 56569175200 | hyejinlee@knu.ac.kr; | ELECTROCHIMICA ACTA | ELECTROCHIM ACTA | 0013-4686 | 1873-3859 | 471 | SCIE | ELECTROCHEMISTRY | 2023 | 5.5 | 23.3 | 0.42 | 2025-06-25 | 4 | 4 | Voltammetric sensor; Alcohol use disorder; Indole-3-lactic acid; CuSn(OH)(6) -MWCNT- beta -cyclodextrin composite; Clinical serum analysis | TRYPTOPHAN; BIOMARKERS | Alcohol use disorder; Clinical serum analysis; CuSn(OH)<sub>6</sub>–MWCNT–β-cyclodextrin composite; Indole-3-lactic acid; Voltammetric sensor | Arginine; Charge transfer; Field emission microscopes; Lactic acid; Liquid chromatography; Mass spectrometry; Multiwalled carbon nanotubes (MWCN); Polycyclic aromatic hydrocarbons; Positive ions; Scanning electron microscopy; X ray photoelectron spectroscopy; Alcohol use disorder; Clinical serum analyse; Cusn(OH)6–MWCNT–β-cyclodextrin composite; Indole-3-lactic acid; L-Arginine; Multi-walled-carbon-nanotubes; MWCNT's; Serum analysis; Serum samples; Voltammetric sensor; Cyclodextrins | English | 2023 | 2023-12-10 | 10.1016/j.electacta.2023.143387 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Microbially catalyzed enhanced bioelectrochemical performance using covalent organic framework-modified cathode in a microbial electrosynthesis system | Electrode modification plays a critical role in enhancing the bioelectrochemical performance of a microbial electrosynthesis system (MES). This study involved the modification of the conventional carbon felt (CF) elec-trode through in situ covalent grafting with a covalent organic framework (TpPa-COF). Subsequently, the per-formance of this modified electrode was assessed as a cathode in MES. Various physical and bioelectrochemical techniques, such as chronoamperometry, cyclic voltammetry, and electrochemical spectroscopy, demonstrated the remarkable stability, reduced electrode resistance, increased current density, and superior bio-electrochemical activity of the modified electrode. The application of COF@CF caused a 3.2-fold improvement in current density, leading to an enhanced production of volatile fatty acids. The rough surface of the COF@CF electrode and its abundant catalytically active sites facilitated the growth of microorganisms, particularly exoelectrogenic and fermentative genera such as Desulfitobacterium, Clostridium, and Desulfovibrio. These findings highlight the promising potential of COF@CF in various bioelectrochemical applications. | Tahir, Khurram; Hussain, Muzammil; Cheong, In Woo; Lee, Dae Sung | Univ Nova Lisboa, Inst Tecnol Quim & Biol Antonio Xavier, Oeiras, Portugal; Kyungpook Natl Univ, Dept Appl Chem, 80 Daehak ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak ro, Daegu 41566, South Korea | Tahir, Khurram/KFS-5321-2024 | 57207114377; 58279975000; 7006733373; 55568524907 | daesung@knu.ac.kr; | ELECTROCHIMICA ACTA | ELECTROCHIM ACTA | 0013-4686 | 1873-3859 | 467 | SCIE | ELECTROCHEMISTRY | 2023 | 5.5 | 23.3 | 0.63 | 2025-06-25 | 5 | 6 | TpPa-COF; Cathode modification; Bioelectrochemical activity; Volatile fatty acid; Microbial community analysis | FUEL-CELL; ELECTRON-TRANSFER; ELECTRICITY-GENERATION; ANODE; CONSTRUCTION; OXIDE | Bioelectrochemical activity; Cathode modification; Microbial community analysis; TpPa-COF; Volatile fatty acid | Chronoamperometry; Cyclic voltammetry; Electrochemical electrodes; Microorganisms; Volatile fatty acids; Bio-electrochemical; Bioelectrochemical activity; Carbon felt electrodes; Carbon felts; Cathode modification; Covalent organic frameworks; Microbial community analysis; Modified electrodes; Performance; Tppum-COF; Cathodes | English | 2023 | 2023-11-01 | 10.1016/j.electacta.2023.143127 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Changes in fecal metabolic and lipidomic features by anti-TNF treatment and prediction of clinical remission in patients with ulcerative colitis | Background:Therapeutic targets for ulcerative colitis (UC) and prediction models of antitumor necrosis factor (TNF) therapy outcomes have not been fully reported. Objective:Investigate the characteristic metabolite and lipid profiles of fecal samples of UC patients before and after adalimumab treatment and develop a prediction model of clinical remission following adalimumab treatment. Design:Prospective, observational, multicenter study was conducted on moderate-to-severe UC patients (n = 116). Methods:Fecal samples were collected from UC patients at 8 and 56 weeks of adalimumab treatment and from healthy controls (HC, n = 37). Clinical remission was assessed using the Mayo score. Metabolomic and lipidomic analyses were performed using gas chromatography mass spectrometry and nano electrospray ionization mass spectrometry, respectively. Orthogonal partial least squares discriminant analysis was performed to establish a remission prediction model. Results:Fecal metabolites in UC patients markedly differed from those in HC at baseline and were changed similarly to those in HC during treatment; however, lipid profiles did not show these patterns. After treatment, the fecal characteristics of remitters (RM) were closer to those of HC than to those of non-remitters (NRM). At 8 and 56 weeks, amino acid levels in RM were lower than those in NRM and similar to those in HC. After 56 weeks, levels of 3-hydroxybutyrate, lysine, and phenethylamine decreased, and dodecanoate level increased in RM similarly to those in HC. The prediction model of long-term remission in male patients based on lipid biomarkers showed a higher performance than clinical markers. Conclusion:Fecal metabolites in UC patients markedly differ from those in HC, and the levels in RM are changed similarly to those in HC after anti-TNF therapy. Moreover, 3-hydroxybutyrate, lysine, phenethylamine, and dodecanoate are suggested as potential therapeutic targets for UC. A prediction model of long-term remission based on lipid biomarkers may help implement personalized treatment. | Kim, Seok-Young; Shin, Seung Yong; Park, Soo Jung; Im, Jong Pil; Kim, Hyo Jong; Lee, Kang-Moon; Kim, Ji Won; Jung, Sung-Ae; Lee, Jun; Kang, Sang-Bum; Shin, Sung Jae; Kim, Eun Sun; Kim, You Sun; Kim, Tae Oh; Kim, Hyun-Soo; Park, Dong Il; Kim, Hyung Kil; Kim, Eun Soo; Kim, Young-Ho; Teng, Dennis; Kim, Jong-Hwa; Kim, Wonyong; Saeed, Maham; Moon, Jung Min; Kim, Kisung; Choi, Chang Hwan; Choi, Hyung-Kyoon | Chung Ang Univ, Coll Med, Internal Med, Med, 102 Heukseok Ro, Seoul 06973, South Korea; Chung Ang Univ, Coll Pharm, 84 Heukseok Ro, Seoul 06974, South Korea; Chung Ang Univ, Coll Pharm, Seoul, South Korea; Chung Ang Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Yonsei Univ, Coll Med, Inst Gastroenterol, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Liver Res Inst, Seoul, South Korea; Kyung Hee Univ Hosp, Dept Gastroenterol, Seoul, South Korea; Catholic Univ Korea, St Vincents Hosp, Dept Gastroenterol, Suwon, South Korea; SMG SNU Boramae Med Ctr, Dept Gastroenterol, Seoul, South Korea; Ewha Womans Univ, Coll Med, Dept Gastroenterol, Seoul, South Korea; Chosun Univ, Dept Internal Med, Coll Med, Gwangju, South Korea; Catholic Univ Korea Daejeon, St Marys Hosp, Dept Gastroenterol, Daejeon, South Korea; Ajou Univ, Sch Med, Dept Gastroenterol, Suwon, South Korea; Korea Univ, Anam Hosp, Dept Gastroenterol, Seoul, South Korea; Inje Univ, Seoul Paik Hosp, Dept Gastroenterol, Seoul, South Korea; Inje Univ, Haeundae Paik Hosp, Dept Gastroenterol, Busan, South Korea; Chonnam Natl Univ Hosp, Dept Gastroenterol, Gwangju, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Seoul, South Korea; Inha Univ Hosp, Dept Gastroenterol, Incheon, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Internal Med, Seoul, South Korea; AbbVie Pte Ltd, Singapore, Singapore; Chung Ang Univ, Dept Microbiol, Coll Med, Seoul, South Korea | kim, hyunsoo/LNP-4811-2024; Kim, Jong-Hwa/AHA-6528-2022; Lee, Jun/MIN-9657-2025; Kim, You Sun/B-2881-2015; kim, juhee/HKV-6163-2023; Kwak, Sang Gyu/AAG-4341-2021; Kim, Hanjun/AAJ-7528-2021; Kim, Sang/J-5398-2012; Kim, Jae-hyung/J-8504-2012; Kim, Hyung/J-5451-2012; Kim, Dong/F-4608-2014; Kim, Wonyong/AAC-3347-2019; Kim, Jong/AAE-4958-2019 | 57200314471; 57202549801; 56042287100; 8108755200; 57219637859; 35196099500; 57204539255; 7403676915; 57202953059; 8837205700; 57221641429; 56308204100; 56565885500; 55603811000; 57210863499; 56524839700; 57941472200; 57203086704; 57210738018; 57787334800; 55917964500; 34770706500; 57618670900; 57214937783; 57205303400; 56799609000; 7404339439 | gicch@cau.ac.kr;hykychoi@cau.ac.kr; | THERAPEUTIC ADVANCES IN GASTROENTEROLOGY | THER ADV GASTROENTER | 1756-283X | 1756-2848 | 16 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 3.9 | 23.4 | 0.2 | 2025-06-25 | 2 | 2 | adalimumab; fecal metabolites; lipidomic analysis; metabolomic analysis; ulcerative colitis | INFLAMMATORY-BOWEL-DISEASE; THERAPY; MICROBIOME; ADALIMUMAB; MODERATE; CHILDREN | adalimumab; fecal metabolites; lipidomic analysis; metabolomic analysis; ulcerative colitis | 3 hydroxybutyric acid; adalimumab; alcohol; amine; amino acid; aspartic acid; bile acid; biological marker; C reactive protein; fatty acid; glutamic acid; glycine; lauric acid; lipid; lipidome; lysine; phenethylamine; pyroglutamic acid; saturated fatty acid; serine; steroid; triacylglycerol; tumor necrosis factor; adult; Article; body mass; clinical assessment; controlled study; diagnostic test accuracy study; discriminant analysis; disease activity; disease severity; drug dose reduction; electrospray mass spectrometry; feces; feces analysis; female; human; lipid fingerprinting; lipidomics; major clinical study; male; mass fragmentography; metabolism; multicenter study; normal human; observational study; prediction; principal component analysis; prospective study; receiver operating characteristic; remission; scoring system; ulcerative colitis | English | 2023 | 2023 | 10.1177/17562848231168199 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Comparative Analysis of High-Intensity versus Low-to-Moderate Intensity Statin Therapy in Patients Undergoing Rotational Atherectomy for Calcified Coronary Artery Disease | (1) Background: Moderate-intensity statin therapy, when compared to high-intensity statin therapy in Asian populations, has shown no significant difference in cardiovascular prognosis in small studies. The aim of this study was to compare the prognosis of patients based on statin intensity following rotational atherectomy (RA) during high-complexity percutaneous coronary intervention (PCI). (2) Methods: The ROCK registry, a multicenter retrospective study, included patients who had undergone rotational atherectomy (RA) during percutaneous coronary intervention (PCI) at nine tertiary medical centers in South Korea between January 2010 and October 2019. The patients were divided into high-intensity statin (H-statin) and moderate/low-intensity statin (M/L-statin) therapy groups. The primary endpoint includes outcomes (cardiac death, target vessel myocardial infarction (MI), and target vessel revascularization (TVR)) within an 18-month follow-up period. (3) Results: In this registry, a total of 540 patients with 583 lesions were included. We excluded 39 lesions from the analysis due to the absence of statin usage. The H-statin group had 394 lesions and the M/L-statin group had 150 lesions. There were no significant differences in baseline characteristics, procedural adverse events without heart failure history, triglycerides, or medications between the two groups. The procedural success rate showed a significant difference between the two groups. Multivariate analysis did not show a significant association between M/L-statin therapy and an increased risk of the primary endpoint. In propensity score matching analysis, no significant difference was observed in the primary endpoint either. (4) Conclusions: In high-complex RA PCI, moderate/low-intensity statin therapy is not inferior to high-intensity statin therapy in Korea. | Choi, Sang-Suk; Jung, Jin; Her, Sung-Ho; Kim, Kyunyeon; Kim, Youngmin; Lee, Kyusup; Yoo, Ki-Dong; Moon, Keon-Woong; Moon, Donggyu; Lee, Su-Nam; Jang, Won-Young; Choi, Ik-Jun; Lee, Jae-Hwan; Lee, Jang-Hoon; Lee, Sang-Rok; Lee, Seung-Whan; Yun, Kyeong-Ho; Lee, Hyun-Jong; Diez-Juan, Antonio | Catholic Univ Korea, St Vincents Hosp, Coll Med, Dept Cardiol, Seoul 16247, South Korea; Catholic Univ Korea, Daejeon St Marys Hosp, Coll Med, Dept Cardiol, Seoul 34943, South Korea; Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Dept Cardiol, Incheon 21431, South Korea; Chungnam Natl Univ, Sejong Hosp, Sch Med, Dept Cardiol Internal Med, Sejong 30099, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu 41944, South Korea; Jeonbuk Natl Univ Hosp, Dept Cardiol, Jeonju 54907, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Cardiol, Seoul 05505, South Korea; Wonkwang Univ Hosp, Reg Cardiocerebrovasc Ctr, Dept Cardiovasc Med, Iksan 54538, South Korea; Sejong Gen Hosp, Dept Internal Med, Bucheon 14754, South Korea | ; Lee, Kyoung/J-5570-2012; Yun, Kyeong Ho/IYS-8810-2023; Lee, Yoon/ABA-8808-2020 | 57965566800; 57224923606; 12806475600; 59121391600; 59123945100; 57204923370; 35082999900; 58305182400; 58912076200; 57218696499; 57195753730; 55486997300; 36066387900; 54581258000; 55887032200; 17233718400; 14424664600; 57202973860 | hhhsungho@naver.com;medorche@naver.com; | LIFE-BASEL | LIFE-BASEL | 2075-1729 | 13 | 11 | SCIE | BIOLOGY | 2023 | 3.2 | 23.4 | 0 | 2025-06-25 | 0 | 0 | statin intensity; rotablation; percutaneous coronary intervention | MYOCARDIAL-INFARCTION; EXPERT CONSENSUS; PHARMACOGENETICS; CALCIFICATION; ROSUVASTATIN; CHOLESTEROL; MANAGEMENT; CALCIUM; LESIONS; EVENTS | percutaneous coronary intervention; rotablation; statin intensity | English | 2023 | 2023-11 | 10.3390/life13112232 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Dynamic Changes in Local Activity and Network Interactions among the Anterior Cingulate, Amygdala, and Cerebellum during Associative Learning | Communication between the cerebellum and forebrain structures is necessary for motor learning and has been implicated in a variety of cognitive functions. The exact nature of cerebellar-forebrain interactions supporting behavior and cognition is not known. We examined how local and network activity support learning by simultaneously recording neural activity in the cerebellum, amygdala, and anterior cingulate cortex while male and female rats were trained in trace eyeblink conditioning. Initially, the cerebellum and forebrain signal the contingency between external stimuli through increases in theta power and synchrony. Neuronal activity driving expression of the learned response was observed in the cerebellum and became evident in the anterior cingulate and amygdala as learning progressed. Aligning neural activity to the training stimuli or learned response provided a way to differentiate between learning-related activity driven by different mechanisms. Stimulus and response-related increases in theta power and coherence were observed across all three areas throughout learning. However, increases in slow gamma power and coherence were only observed when oscillations were aligned to the cerebellum-driven learned response. Percentage of learned responses, learning-related local activity, and slow gamma communication from cerebellum to forebrain all progressively increased during training. The relatively fast frequency of slow gamma provides an ideal mechanism for the cerebellum to communicate learned temporal information to the forebrain. This cerebellar response-aligned slow gamma then provides enrichment of behavior-specific temporal information to local neuronal activity in the forebrain. These dynamic network interactions likely support a wide range of behaviors and cognitive tasks that require coordination between the forebrain and cerebellum. | Halverson, Hunter E.; Kim, Jangjin; Freeman, John H. | Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA; Univ Iowa, Dept Psychol & Brain Sci, Iowa City, IA 52242 USA; Kyungpook Natl Univ, Dept Psychol, Daegu 41566, South Korea; Univ Iowa, Iowa Neurosci Inst, Iowa City, IA 52242 USA | 6701468736; 36646018100; 7403529874 | hunter-halverson@uiowa.edu; | JOURNAL OF NEUROSCIENCE | J NEUROSCI | 0270-6474 | 1529-2401 | 43 | 49 | SCIE | NEUROSCIENCES | 2023 | 4.4 | 23.4 | 0.74 | 2025-06-25 | 5 | 5 | amygdala; anterior cingulate; cerebellum; slow gamma; theta; trace eyeblink conditioning | HIPPOCAMPAL THETA-RHYTHM; PREFRONTAL CORTEX; GAMMA OSCILLATIONS; PERSISTENT ACTIVITY; PREDICTIVE CONTROL; INTERNAL-MODELS; PHASE; ACQUISITION; FREQUENCY; REORGANIZATION | Amygdala; Animals; Cerebellum; Conditioning, Classical; Conditioning, Eyelid; Female; Gyrus Cinguli; Male; Rats; amygdala; anterior cingulate; article; associative learning; cerebellum; cognition; eyeblink conditioning; female; forebrain; learning; male; motor learning; oscillation; rat; amygdala; animal; cerebellum; cingulate gyrus; classical conditioning; eyeblink conditioning; physiology | English | 2023 | 2023-12-06 | 10.1523/jneurosci.0731-23.2023 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effects of Mycotoxin-Sequestering Agents on Growth Performance and Nutrient Utilization of Growing Pigs Fed Deoxynivalenol-Contaminated Diets | The objective of this study was to investigate the effects of supplemental mycotoxin-sequestering agents on growth performance and nutrient utilization in growing pigs fed deoxynivalenol (DON)-contaminated diets. Twelve barrows with an initial body weight of 35.5 kg (standard deviation = 1.3) were assigned to six dietary treatments in a replicated 6 x 5 incomplete Latin square design. Five experimental diets consisted of an uncontaminated diet (PC), a DON-contaminated diet at 6.89 mg/kg (NC), NC + bentonite 0.5%, NC + yeast cell wall 0.5%, and NC + a mixture product 0.5% which consisted of enzymes, microorganisms, minerals, and plant extracts. Pigs had ad libitum access to the five diets. In the last group, the PC diet was restrictedly provided to pigs at the quantity of feed consumption of the NC group. Average daily gain, average daily feed intake, and gain:feed were not affected by supplemental mycotoxin-sequestering agents except for the mixed product that tended to improve (p = 0.064) gain:feed in pigs fed DON-contaminated diets. The apparent total tract digestibility (ATTD) of dry matter was not affected by DON contamination or by supplemental mycotoxin-sequestering agents, whereas the ATTD of Ca was decreased (p = 0.032) by supplemental yeast cell wall in pigs fed DON-contaminated diets. The ATTD of P was greater (p = 0.042) in pigs fed the NC diet compared with the pigs fed the restricted amount of the PC diet. In conclusion, bentonite and yeast cell wall did not affect growth performance of pigs fed DON-contaminated diets, but a supplemental mixed product consisting of enzymes, microorganisms, minerals, and plant extracts partially alleviated the negative effects of dietary DON on the gain:feed of pigs. Calcium digestibility was decreased by supplemental yeast cell wall in pigs fed DON-contaminated diets. Based on the present work, the use of a mixed product consisting of enzymes, microorganisms, minerals, and plant extracts is suggested, and the reduction of Ca digestibility by yeast cell wall needs to be considered in diet formulations. | Kwon, Woong Bi; Shin, Seung Youp; Song, Yoon Soo; Kong, Changsu; Kim, Beob Gyun | Furst McNess Co, Rockford, IL 61108 USA; Konkuk Univ, Dept Anim Sci & Technol, Seoul 05029, South Korea; Kyungpook Natl Univ, Dept Anim Sci, Sangju 37224, South Korea | ; Kim, Beob/B-5634-2009 | 57206307133; 55932976200; 58420388500; 36027521600; 26654167200 | woongbi.kwon@mcness.com;shinsy02@konkuk.ac.kr;sang8sys@konkuk.ac.kr;changsukong@knu.ac.kr;bgkim@konkuk.ac.kr; | LIFE-BASEL | LIFE-BASEL | 2075-1729 | 13 | 10 | SCIE | BIOLOGY | 2023 | 3.2 | 23.4 | 0.77 | 2025-06-25 | 4 | 4 | deoxynivalenol; digestibility; feed intake; growing pigs; sequestering agent | FUSARIUM MYCOTOXINS; SERUM CHEMISTRY; NURSERY PIGS; FEED-INTAKE; DIGESTIBILITY; EFFICACY; GLUCOMANNAN; AFLATOXIN; WHEAT; ZEARALENONE | deoxynivalenol; digestibility; feed intake; growing pigs; sequestering agent | English | 2023 | 2023-10 | 10.3390/life13101953 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | EULAR Sjogren's Syndrome Patient Reported Index (ESSPRI) and Other Patient-Reported Outcomes in the Assessment of Glandular Dysfunction in Primary Sjögren's Syndrome | The EULAR Sjogren's Syndrome Disease Activity Index (ESSDAI), EULAR Sjogren's Syndrome Patient Reported Index (ESSPRI), and other patient-reported outcomes (PROs), such as the visual analog scale (VAS) for symptoms and EULAR sicca score (ESS), are used to assess the disease activity of primary Sjogren's syndrome (pSS). Recently, Clinical ESSDAI (ClinESSDAI) and Clinical Trials ESSDAI (ClinTrialsESSDAI) were developed for objective clinical disease activity indexes. However, the relationship of ClinESSDAI and ClinTrialsESSDAI with PROs as well as that between ESSPRI and other PROs and the objective parameters of glandular function in pSS have not been established. Herein, we investigated the correlation of ESSPRI and other PROs with the objective parameters of glandular function and the relationship of PROs with ClinESSDAI and ClinTrialsESSDAI in 66 patients with pSS. Correlations were calculated with Spearman's correlation coefficient. ClinTrialsESSDAI was correlated with ESSPRI, dryness (ESSPRI-Dryness), fatigue, and pain domains of ESSPRI, VAS for oral dryness (oral-VAS), and patient's global assessment. Although ESSPRI did not correlate with the objective parameters of glandular function, ESSPRI-Dryness, ESS, and oral- and ocular-VAS did. These results suggest that ESSPRI-Dryness, ESS, and VAS for symptoms, but not ESSPRI, reflect the glandular dysfunction and that ClinTrialsESSDAI correlates with PROs for dryness in pSS. | Ture, Hirut Yadeta; Kim, Na Ri; Nam, Eon Jeong | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Rheumatol, Daegu 42113, South Korea | 58112648500; 58113116000; 7005824293 | danucharmy@gmail.com;nr2251@hanmail.net;ejnam@knu.ac.kr; | LIFE-BASEL | LIFE-BASEL | 2075-1729 | 13 | 10 | SCIE | BIOLOGY | 2023 | 3.2 | 23.4 | 1.16 | 2025-06-25 | 6 | 6 | Sjogren's syndrome; ESSPRI; patient-reported outcomes; ClinTrialsESSDAI; glandular dysfunction | KERATOCONJUNCTIVITIS SICCA; CLASSIFICATION CRITERIA; CORNEAL SENSITIVITY; SALIVARY FLOW; CONSENSUS; SYMPTOMS; DIAGNOSIS; FATIGUE; LEAGUE | ClinTrialsESSDAI; ESSPRI; glandular dysfunction; patient-reported outcomes; Sjogren’s syndrome | English | 2023 | 2023-10 | 10.3390/life13101991 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | Gut Microbiota in Autophagy Regulation: New Therapeutic Perspective in Neurodegeneration | Gut microbiota and the brain are related via a complex bidirectional interconnective network. Thus, intestinal homeostasis is a crucial factor for the brain, as it can control the environment of the central nervous system and play a significant role in disease progression. The link between neuropsychological behavior or neurodegeneration and gut dysbiosis is well established, but many involved pathways remain unknown. Accumulating studies showed that metabolites derived from gut microbiota are involved in the autophagy activation of various organs, including the brain, one of the major pathways of the protein clearance system that is essential for protein aggregate clearance. On the other hand, some metabolites are evidenced to disrupt the autophagy process, which can be a modulator of neurodegeneration. However, the detailed mechanism of autophagy regulation by gut microbiota remains elusive, and little research only focused on that. Here we tried to evaluate the crosstalk between gut microbiota metabolites and impaired autophagy of the central nervous system in neurodegeneration and the key to future research regarding gut dysbiosis and compromised autophagy in neurodegenerative diseases. | Mitra, Sarmistha; Munni, Yeasmin Akter; Dash, Raju; Sadhu, Toma; Barua, Largess; Islam, Md. Ariful; Chowdhury, Dipannita; Bhattacharjee, Debpriya; Mazumder, Kishor; Moon, Il Soo | Dongguk Univ, Coll Med, Dept Anat, Gyeongju 38066, South Korea; Daegu Gyeongbuk Inst Sci & Technol, Dept New Biol, Daegu 42988, South Korea; Asian Univ Women, Dept Bioinformat & Biotechnol, Chittagong 4000, Bangladesh; Kyungpook Natl Univ, Sch Dent, Dept Anat & Neurobiol, Daegu 41940, South Korea; North South Univ, Dept Pharmaceut Sci, Dhaka 1229, Bangladesh; BGC Trust Univ Bangladesh, Dept Pharm, Chittagong 4381, Bangladesh; Brandenburg Tech Univ Cottbus Senftenberg, Fac Environm & Nat Sci, D-03013 Cottbus, Germany; Jashore Univ Sci & Technol, Dept Pharm, Jashore 7408, Bangladesh; Univ New South Wales UNSW, Sch Optometry & Vis Sci, UNSW Med, Sydney, NSW 2052, Australia | Munni, Yeasmin/JAZ-1363-2023; Islam, Md Ariful/IZE-2734-2023; MOON, IL/AFK-2781-2022; Mitra, Sarmistha/ABD-2904-2021; Mazumder, Kishor/P-6296-2019 | 57201288944; 57219471023; 56605919500; 58205395600; 57219472674; 59810378700; 58205522800; 58205028900; 35722616200; 7101610481 | moonis@dongguk.ac.kr; | LIFE-BASEL | LIFE-BASEL | 2075-1729 | 13 | 4 | SCIE | BIOLOGY | 2023 | 3.2 | 23.4 | 0.31 | 2025-06-25 | 5 | 5 | gut microbiota; autophagy; neurodegenerative diseases; brain injuries | CHAIN FATTY-ACIDS; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; MOUSE MODEL; TRYPTOPHAN-METABOLISM; CALORIE RESTRICTION; HUNTINGTONS-DISEASE; MULTIPLE-SCLEROSIS; BRAIN-FUNCTION; EMERGING ROLE | autophagy; brain injuries; gut microbiota; neurodegenerative diseases | English | 2023 | 2023-04 | 10.3390/life13040957 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Profiling of Lymphovascular Space Invasion in Cervical Cancer Revealed PI3K/Akt Signaling Pathway Overactivation and Heterogenic Tumor-Immune Microenvironments | Lymphovascular space invasion (LVSI) is the presence of tumor emboli in the endothelial-lined space at the tumor body's invasive edge. LVSI is one of three Sedlis criteria components-a prognostic tool for early cervical cancer (CC)-essential for indicating poor prognosis, such as lymph node metastasis, distant metastasis, or shorter survival rate. Despite its clinical significance, an in-depth comprehension of the molecular mechanisms or immune dynamics underlying LVSI in CC remains elusive. Therefore, this study investigated tumor-immune microenvironment (TIME) dynamics of the LVSI-positive group in CC. RNA sequencing included formalin-fixed paraffin-embedded (FFPE) slides from 21 CC patients, and differentially expressed genes (DEGs) were analyzed. Functional analysis and immune deconvolution revealed aberrantly enriched PI3K/Akt pathway activation and a heterogenic immune composition with a low abundance of regulatory T cells (Treg) between LVSI-positive and LVSI-absent groups. These findings improve the comprehension of LSVI TIME and immune mechanisms, benefiting targeted LVSI therapy for CC. | Choi, Yeseul; Ando, Yu; Lee, Donghyeon; Kim, Na Young; Lee, Olive E. M.; Cho, Junghwan; Seo, Incheol; Chong, Gun Oh; Park, Nora Jee-Young | Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, Grad Program, Daegu 41944, South Korea; Kyungpook Natl Univ, Clin Omics Inst, Daegu 41405, South Korea; Kyungpook Natl Univ, Sch Med, Dept Immunol, Daegu 41944, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Obstet & Gynecol, Daegu 41404, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Pathol, Daegu 41404, South Korea | Kim, Na-young/KHU-6533-2024; Cho, Junghwan/AAK-4752-2020 | 57226123444; 57295299200; 57870503500; 59122269200; 58029901300; 57424663500; 56022683900; 23099068000; 57226185359 | yeseul.choi830@knu.ac.kr;yuando@knu.ac.kr;lowellkids24@knu.ac.kr;skduddl98@knu.ac.kr;olive@knu.ac.kr;joshua@knu.ac.kr;iseo@knu.ac.kr;gochong@knu.ac.kr;pathpjy@knu.ac.kr; | LIFE-BASEL | LIFE-BASEL | 2075-1729 | 13 | 12 | SCIE | BIOLOGY | 2023 | 3.2 | 23.4 | 0.19 | 2025-06-25 | 1 | 1 | cervical cancer; lymphovascular space invasion; RNA sequencing; PI3K/Akt signaling pathway; sustained angiogenesis; immune deconvolution; tumor immune microenvironment; TIME; regulatory T cells | REGULATORY T-CELLS; PROGNOSTIC-FACTOR; P110-ALPHA ISOFORM; ANGIOGENESIS; INVOLVEMENT; CARCINOMA; SURVIVAL | cervical cancer; immune deconvolution; lymphovascular space invasion; PI3K/Akt signaling pathway; regulatory T cells; RNA sequencing; sustained angiogenesis; TIME; tumor immune microenvironment | English | 2023 | 2023-12 | 10.3390/life13122342 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Real-life effectiveness and safety of tofacitinib treatment in patients with ulcerative colitis: a KASID multicenter cohort study | Background:Tofacitinib is a small molecule that inhibits Janus kinase and has been reported to be effective in Western patients with ulcerative colitis (UC). However, the real-life data on tofacitinib in Asian UC patients are limited. Objective:To investigate the real-life effectiveness and safety of tofacitinib induction and maintenance treatment in Korean patients with UC. Design:This was a retrospective study on patients with UC who received tofacitinib treatment at 12 hospitals in Korea between January 2018 and November 2020. Methods:Clinical remission at week 52, defined as a partial Mayo score of <= 2 with a combined rectal bleeding subscore and stool frequency subscore of <= 1, was used as the primary outcome. Adverse events (AEs), including herpes zoster and deep vein thrombosis, were also evaluated. Results:A total of 148 patients with UC were started on tofacitinib. Clinical remission rates of 60.6%, 54.9%, and 52.8% were reported at weeks 16, 24, and 52, respectively. Clinical response rates of 71.8%, 67.6%, and 59.9% were reported at weeks 16, 24, and 52, respectively. Endoscopic remission rates at weeks 16 and 52 were 52.4% and 30.8% based on the Mayo endoscopic subscore and 20.7% and 15.2% based on the UC endoscopic index of severity (UCEIS), respectively. A higher UCEIS at baseline was negatively associated with clinical response [adjusted odds ratio (aOR): 0.774, p = 0.029] and corticosteroid-free clinical response (aOR: 0.782, p = 0.035) at week 52. AEs occurred in 19 patients (12.8%) and serious AEs in 12 patients (8.1%). Herpes zoster occurred in four patients (2.7%). One patient (0.7%) suffered from deep vein thrombosis. Conclusions:Tofacitinib was an effective induction and maintenance treatment with an acceptable safety profile in Korean patients with UC. Plain language summaryReal-life effectiveness and safety of tofacitinib treatment in Korean patients with ulcerative colitisUlcerative colitis (UC) is an idiopathic, chronic inflammatory disorder of the colonic mucosa that usually presents with bloody diarrhea and abdominal pain. Tofacitinib is a small molecule that inhibits Janus kinase and has been reported to be effective in Western patients with UC. However, real-life data on the effectiveness of tofacitinib in Asian patients with UC are limited. To investigate the real-life effectiveness and safety of tofacitinib treatment in Korean patients with UC, we retrospectively analyzed the data of 148 patients with UC who received tofacitinib treatment at 12 hospitals in Korea between January 2018 and November 2020. Clinical remission (i.e. complete improvement of symptoms) was achieved in 60.6% and 52.8% of patients at weeks 16 and 52, respectively. Endoscopic remission was achieved in 52.4% and 30.8% of patients at weeks 16 and 52, respectively. A higher baseline score of the UC endoscopic index of severity, which is one of the endoscopic indices that evaluate the severity of inflammation of the colon, was negatively associated with clinical response (i.e. partial improvement of symptoms). Adverse events (AEs) including herpes zoster and deep vein thrombosis occurred in 19 patients (12.8%) and serious AEs occurred in 12 patients (8.1%). Our real-life study shows that tofacitinib is a clinically effective treatment for Korean patients with UC, and the incidence of AEs was also similar to those observed in other real-world studies. | Shin, Seung Hwan; Oh, Kyunghwan; Hong, Sung Noh; Lee, Jungbok; Oh, Shin Ju; Kim, Eun Soo; Na, Soo-Young; Kang, Sang-Bum; Koh, Seong-Joon; Bang, Ki Bae; Jung, Sung-Ae; Jung, Sung Hoon; Kim, Kyeong Ok; Park, Sang Hyoung; Yang, Suk-Kyun; Choi, Chang Hwan; Ye, Byong Duk | Chung Ang Univ, Coll Med, Dept Internal Med, 102 Heukseok Ro, Seoul 06973, South Korea; Univ Ulsan, Asan Med Ctr, Dept Gastroenterol, Coll Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea; Univ Ulsan, Coll Med, Inflammatory Bowel Dis Ctr, Asan Med Ctr, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea; Univ Ulsan, Asan Med Ctr, Dept Gastroenterol, Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Med, Seoul, South Korea; Asan Med Ctr, Dept Biostat & Clin Epidemiol, Seoul, South Korea; Kyung Hee Univ, Coll Med, Dept Gastroenterol, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol, Daegu, South Korea; Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Dept Internal Med, Incheon, South Korea; Catholic Univ Korea, Daejeon St Marys Hosp, Coll Med, Dept Internal Med, Daejeon, South Korea; Seoul Natl Univ, Coll Med, Dept Internal Med, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Liver Res Inst, Seoul, South Korea; Dankook Univ, Coll Med, Dept Internal Med, Cheonan, South Korea; Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Catholic Univ Korea, Eunpyeong St Marys Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Yeungnam Univ, Coll Med, Dept Internal Med, Div Gastroenterol & Hepatol, Daegu, South Korea; Univ Ulsan, Inflammatory Bowel Dis Ctr, Asan Med Ctr, Dept Gastroenterol,Coll Med, Seoul, South Korea | Hong, Sung Noh/MTB-0511-2025; Ye, Byong/AAF-4955-2020; Kwak, Sang Gyu/AAG-4341-2021; Kim, Sang/J-5398-2012; Park, Sang Hyoung/CAH-4735-2022 | 57214317626; 57192707263; 57220761219; 16202847300; 57197763164; 57203086704; 55682497900; 8837205700; 42061746300; 57204337211; 7403676915; 57217441411; 53363798100; 34977204700; 7406948347; 56799609000; 14069472300 | gicch@cau.ac.kr;bdye@amc.seoul.kr; | THERAPEUTIC ADVANCES IN GASTROENTEROLOGY | THER ADV GASTROENTER | 1756-283X | 1756-2848 | 16 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 3.9 | 23.4 | 1.37 | 2025-06-25 | 8 | 7 | effectiveness; safety; tofacitinib; ulcerative colitis | LONG-TERM PROGNOSIS; MAINTENANCE THERAPY; CLINICAL-RESPONSE; ENDOSCOPIC INDEX; INDUCTION; OUTCOMES; SCORE; GUIDELINES; INFLIXIMAB; REMISSION | effectiveness; safety; tofacitinib; ulcerative colitis | azathioprine; C reactive protein; calgranulin; corticosteroid; Janus kinase; tofacitinib; abdominal pain; Article; cardiovascular disease; chronic inflammation; clinical outcome; Clostridium difficile infection; cohort analysis; colectomy; colitis; colon mucosa; deep vein thrombosis; dermatome; disease activity; disease duration; disease severity; drug efficacy; drug safety; endoscopy; female; follow up; herpes zoster; human; incidence; lung embolism; lung tuberculosis; maintenance therapy; major clinical study; male; multicenter study; observational study; outcome assessment; popliteal vein; rectum hemorrhage; retrospective study; treatment response; ulcerative colitis; ulcerative colitis endoscopic index of severity | English | 2023 | 2023 | 10.1177/17562848231154103 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Screening of Linum usitatissimum Lines Using Growth Attributes, Biochemical Parameters and Ionomics Under Salinity Stress | Salt stress causes plants to undergo metabolic and physiological disturbances, affecting growth, development, quality, and yield. With the increasing demand for food in the world and this environmental problem, the cultivation of salt-tolerant varieties or lines of crops is needed to compensate for the demands of food for mankind. This study was designed for salt tolerance problems; the four lines of Linum usitatissimum in terms of the plant's agronomic attributes, yield, different metabolites (secondary and primary), antioxidant enzymatic activities, endogenous hormones, lipid peroxidation and ion analysis. This research was completely randomized-design (CRD) and four lines of flax (Alsi ARI-50, Alsi ARI-22, Alsi ARI-20 and Alsi ARI-1) were raised using water (control) and 150 mM NaCl in irrigation water. Salinity had a negative impact on different growth parameters, photosynthetic pigments-level (Chlorophyll a, Chlorophyll b, total chlorophyll and chlorophyll a/b ratio), Indole-3-acetic acid (IAA), and different essential ions. On the other hand, at the same salt concentrations, carotenoid content, sugar level, total protein, lipids, phenolic content, proline amount, flavonoid, tannin, beta carotene, antioxidant level, lipid peroxidation, catalase activity, guaiacol peroxidase activity, ascorbic acid, salicylic acid, sodium and chloride ions significantly increased. Based on the present study, it was concluded that Alsi ARI-50 and Alsi ARI-22 showed higher salt tolerance compared to the other lines based on measured parameters. So, these lines are recommended to be used in the salinity area and also in the breeding programme. | Pervaiz, Sadaf; Gul, Humaira; Rauf, Mamoona; Mohamed, Heba I.; Ur Rehman, Khushnood; Wasila, Humaira; Ahmad, Imran; Shah, Syed Tanveer; Basit, Abdul; Ahmad, Masood; Akbar, Sultan; Fahad, Shah | Abdul Wali Khan Univ, Dept Bot, Mardan, Khyber Pukhtunk, Pakistan; Ain Shams Univ, Fac Educ, Dept Biol & Geol Sci, Cairo, Egypt; Islamia Coll Peshawar, Dept Bot, Peshawar, Pakistan; Univ Agr, Dept Human Nutr, Peshawar, Pakistan; Univ Agr, Fac Crop Prod Sci, Dept Hort, Peshawar 25120, Pakistan; Kyungpook Natl Univ, Dept Hort, Daegu 41566, South Korea; Univ Agr, Dept Plant Breeding & Genet, Peshawar, Pakistan; Abdul Wali Khan Univ, Dept Agron, Mardan 23200, Khyber Pakhtunk, Pakistan | Basit, Abdul/AAX-2414-2021; mohamed, heba/U-8673-2019; Ur Rehman, Khushnood/AAZ-1451-2021; rauf, mamoona/AAC-3246-2019; Shah, Syed Tasadaque/AAB-4890-2021; Fahad, Shah/J-7265-2019; Rauf, Mamoona/AAC-3246-2019 | 57345937300; 7003592765; 55609311400; 37102371200; 57220007137; 55318701900; 9532363200; 56089730700; 57218918852; 57301575300; 57901250800; 57208140479 | hebaibrahim79@gmail.com; | GESUNDE PFLANZEN | GESUNDE PFLANZ | 0367-4223 | 1439-0345 | 75 | 6 | SCIE | AGRONOMY | 2023 | 2.4 | 23.4 | 1.4 | 2025-06-25 | 4 | 6 | Catalase; Flax; IAA; Lipids; Proline; Phenols; Salinity; Vegetative Growth | ANTIOXIDANT ENZYMES; NACL STRESS; SALT STRESS; RAPID-DETERMINATION; LIPID-PEROXIDATION; FATTY-ACID; TOLERANCE; L.; DEFENSE; CHLOROPHYLL | Catalase; Flax; IAA; Lipids; Phenols; Proline; Salinity; Vegetative Growth | biochemical composition; catalyst; lipid; metabolite; phenol; salinity tolerance | English | 2023 | 2023-12 | 10.1007/s10343-023-00880-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Tat-RAN attenuates brain ischemic injury in hippocampal HT-22 cells and ischemia animal model | Oxidative stress plays a key role in the pathogenesis of neuronal injury, including ischemia. Ras-related nuclear protein (RAN), a member of the Ras superfamily, involves in a variety of biological roles, such as cell division, proliferation, and signal transduction. Although RAN reveals antioxidant effect, its precise neuroprotective mechanisms are still unclear. Therefore, we investigated the effects of RAN on HT-22 cell which were exposed to H2O2-induced oxidative stress and ischemia animal model by using the cell permeable Tat-RAN fusion protein. We showed that Tat-RAN transduced into HT-22 cells, and markedly inhibited cell death, DNA fragmentation, and reactive oxygen species (ROS) generation under oxidative stress. This fusion protein also controlled cellular signaling pathways, including mitogen-activated protein kinases (MAPKs), NF-kappa B, and apoptosis (Caspase-3, p53, Bax and Bcl-2). In the cerebral forebrain ischemia animal model, Tat-RAN significantly inhibited both neuronal cell death, and astrocyte and microglia activation. These results indicate that RAN significantly protects against hippocampal neuronal cell death, suggesting Tat-RAN will help to develop the therapies for neuronal brain diseases including ischemic injury. | Yeo, Eun Ji; Shin, Min Jea; Youn, Gi Soo; Park, Jung Hwan; Yeo, Hyeon Ji; Kwon, Hyun Jung; Lee, Lee Re; Kim, Na Yeon; Kwon, Su Yeon; Kim, Su Min; Lee, Jaehak; Lee, Keun Wook; Lee, Chan Hee; Cho, Yong-Jun; Kwon, Oh-Shin; Kim, Dae Won; Jung, Hyo Young; Eum, Won Sik; Choi, Soo Young | Hallym Univ, Dept Biomed Sci, Chunchon 24252, South Korea; Hallym Univ, Res Inst Biosci & Biotechnol, Chunchon 24252, South Korea; Hallym Univ Med Ctr, Dept Neurosurg, Chunchon 24253, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci, Taegu 41566, South Korea; Gangneung Wonju Natl Univ, Res Inst Oral Sci, Coll Dent, Dept Biochem & Mol Biol, Kangnung 25457, South Korea; Chungnam Natl Univ, Dept Vet Med, Daejeon 34134, South Korea; Chungnam Natl Univ, Inst Vet Sci, Daejeon 34134, South Korea | lee, lee/KHW-4323-2024; Lee, In-Hyun/D-4531-2011; Kim, Su Min/HOA-9063-2023; Kim, Nam Hoon/HNS-5794-2023 | 56406995100; 35485651200; 54894334000; 57190766857; 55894879100; 57190062260; 57224568196; 57226179942; 58093198400; 58174842500; 58260007000; 57215871305; 57207257659; 55277889800; 7402195859; 56194913400; 55798391300; 6602752494; 56912545700 | wseum@hallym.ac.kr;sychoi@hallym.ac.kr; | NEUROCHEMISTRY INTERNATIONAL | NEUROCHEM INT | 0197-0186 | 1872-9754 | 167 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;NEUROSCIENCES | 2023 | 4.4 | 23.4 | 0.42 | 2025-06-25 | 3 | 3 | Tat-RAN; Ischemic injury; Oxidative stress; MAPK; Protein therapy | TRANSIENT FOREBRAIN ISCHEMIA; LIPOIC ACID PROTECTS; OXIDATIVE STRESS; CEREBRAL-ISCHEMIA; REPERFUSION INJURY; PANCREATIC-CANCER; GTPASE; EXPRESSION; ROLES; DEATH | Ischemic injury; MAPK; Oxidative stress; Protein therapy; Tat-RAN | Animals; Apoptosis; Brain Injuries; Brain Ischemia; Disease Models, Animal; Gene Products, tat; Hippocampus; Hydrogen Peroxide; Ischemia; Neuroprotective Agents; Oxidative Stress; ran GTP-Binding Protein; antioxidant; caspase 3; fusion protein; hydrogen peroxide; immunoglobulin enhancer binding protein; mitogen activated protein kinase; neuroprotective agent; protein Bax; protein bcl 2; protein p53; reactive oxygen metabolite; Tat ras related nuclear protein fusion protein; unclassified drug; hydrogen peroxide; neuroprotective agent; Ran protein; Tat protein; animal cell; animal experiment; animal model; animal tissue; antioxidant activity; Article; astrocyte; brain ischemia; cell activation; controlled study; DNA fragmentation; forebrain; genetic transduction; hippocampus; HT22 cell line; male; MAPK signaling; microglia; mouse; neuroapoptosis; neuroprotection; NF kB signaling; nonhuman; oxidative stress; animal; apoptosis; brain injury; brain ischemia; disease model; genetics; hippocampus; ischemia; metabolism | English | 2023 | 2023-07 | 10.1016/j.neuint.2023.105538 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | The Prevalence of Symptomatic Congenital Cytomegalovirus Disease in Korea; A 15-Year Multicenter Study and Analysis of Big Data From National Health Insurance System | This study is the first multicenter study to estimate the birth prevalence of symptomatic congenital cytomegalovirus disease in Korea. The prevalence was 0.06 % and the administrative prevalence was 0.01% for overall congenital cytomegalovirus infection. The birth prevalence of symptomatic congenital cytomegalovirus (cCMV) disease among live birth in Korea from a multicenter study was 0.06% during 2001-2015 with increasing frequency. The administrative prevalence of cCMV infection by big-data analysis from the national health insurance system was 0.01% and the average healthcare cost was US$2010 per person. | Choi, Sae Rom; Kim, Kyung-Ran; Son, Sohee; Kim, Dong Sub; Chang, Yun Sil; Cho, Eun Young; Chang, Mea-Young; Kim, Yun-Kyung; Jo, Dae Sun; Kim, Jin Kyu; Cho, Hye-Kyung; Park, Su Eun; Park, Kyung Hee; Kim, Hwang Min; Lee, Byung-Kook; Kim, Yae-Jean | Sungkyunkwan Univ, Samsung Med Ctr, Dept Pediat, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea; Kyungpook Natl Univ, Dept Pediat, Childrens Hosp, Daegu, South Korea; Chungnam Natl Univ, Dept Pediat, Sch Med, Daejeon, South Korea; Korea Univ, Dept Pediat, Ansan Hosp, Ansan, South Korea; Jeonbuk Natl Univ, Dept Pediat, Childrens Hosp, Jeonju, South Korea; Gachon Univ, Dept Pediat, Gil Med Ctr, Incheon, South Korea; Pusan Natl Univ, Dept Pediat, Childrens Hosp, Yangsan, South Korea; Pusan Natl Univ Hosp, Dept Pediat, Pusan, South Korea; Yonsei Univ, Dept Pediat, Wonju Coll Med, Wonju, South Korea; Samsung Adv Inst Hlth Sci & Technol, Sch Med, Dept Pediat, Seoul, South Korea; Gyeongsang Natl Univ, Dept Pediat, Changwon Hosp, Chang Won, South Korea | Cho, EunYoung/KHD-4039-2024; KIM, YUN/E-8331-2011; Park, SuEun/KHV-9023-2024; kim, jong-eun/B-3550-2017; Kim, Hyo/AAQ-3152-2020; Kim, Dong/G-7392-2017; Kim, Junetae/AAS-1234-2021; Jo, Dae/S-2762-2019 | 57203744913; 57190005709; 57651046200; 57205248455; 14041061300; 56426759100; 36934023000; 8709854400; 57556166600; 50061384600; 57037510300; 36465325900; 57020246400; 7410139625; 58119091100; 7410198066 | yaejeankim@skku.edu; | JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY | J PEDIAT INF DIS SOC | 2048-7193 | 2048-7207 | 12 | 2 | SCIE | INFECTIOUS DISEASES;PEDIATRICS | 2023 | 2.5 | 23.4 | 0.51 | 2025-06-25 | 3 | 2 | congenital; cytomegalovirus; Korea; sensorineural hearing loss; seroprevalence | congenital; cytomegalovirus; Korea; sensorineural hearing loss; seroprevalence | Big Data; Cytomegalovirus; Cytomegalovirus Infections; Hearing Loss, Sensorineural; Humans; Infant; Prevalence; Republic of Korea; alanine aminotransferase; ganciclovir; valganciclovir; Article; cochlear implantation; congenital cytomegalovirus infection; cytomegalovirus infection; follow up; hearing test; hepatitis; hepatomegaly; human; infant; intrauterine growth retardation; jaundice; major clinical study; microcephaly; multicenter study; newborn; petechia; prevalence; public health; retinitis; seroprevalence; splenomegaly; thrombocytopenia; clinical trial; Cytomegalovirus; cytomegalovirus infection; perception deafness; prevalence; South Korea | English | 2023 | 2023-02-27 | 10.1093/jpids/piac118 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Tumor-associated macrophages as a potential therapeutic target in thyroid cancers | Macrophages are important precursor cell types of the innate immune system and bridge adaptive immune responses through the antigen presentation system. Meanwhile, macrophages constitute substantial portion of the stromal cells in the tumor microenvironment (TME) (referred to as tumor-associated macrophages, or TAMs) and exhibit conflicting roles in the development, invasion, and metastasis of thyroid cancer (TC). Moreover, TAMs play a crucial role to the behavior of TC due to their high degree of infiltration and prognostic relevance. Generally, TAMs can be divided into two subgroups; M1-like TAMs are capable of directly kill tumor cells, and recruiting and activating other immune cells in the early stages of cancer. However, due to changes in the TME, M2-like TAMs gradually increase and promote tumor progression. This review aims to discuss the impact of TAMs on TC, including their role in tumor promotion, gene mutation, and other factors related to the polarization of TAMs. Finally, we will explore the M2-like TAM-centered therapeutic strategies, including chemotherapy, clinical trials, and combinatorial immunotherapy. | Zhu, Liya; Li, Xiu Juan; Gangadaran, Prakash; Jing, Xiuli; Ahn, Byeong-Cheol | Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Qingdao Univ, Affiliated Taian City Cent Hosp, Dept Radiol, Tai An 271000, Shandong, Peoples R China; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, FOUR KNU Convergence Educ Program Biomed Sci Creat, Daegu 41944, South Korea; Shandong First Med Univ, Ctr Life Sci Res, Sch Chem & Pharmaceut Engn, Tai An 271000, Shandong, Peoples R China; Shandong Acad Med Sci, Tai An 271000, Shandong, Peoples R China; Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu 41944, South Korea | ; Gangadaran, Prakash/AAV-3102-2021; jing, xiuli/JWO-1372-2024 | 57190870383; 57206741719; 54393130400; 54781461300; 7202791511 | liyazhu1001@gmail.com;myfly2006@126.com;prakashg@knu.ac.kr;jingxiuli84@163.com;abc2000@knu.ac.kr; | CANCER IMMUNOLOGY IMMUNOTHERAPY | CANCER IMMUNOL IMMUN | 0340-7004 | 1432-0851 | 72 | 12 | SCIE | IMMUNOLOGY;ONCOLOGY | 2023 | 4.6 | 23.4 | 0.71 | 2025-06-25 | 13 | 12 | Tumor-associated macrophages; Tumor microenvironment; Cancer metastasis; Thyroid cancer; Immunotherapy | LYMPH-NODE METASTASIS; NANOPARTICLES PROMOTE; MEDIATED DESTRUCTION; COLORECTAL-CANCER; HUMAN THYROCYTES; DENDRITIC CELLS; POLARIZATION; EXPRESSION; CARCINOMA; M1 | Cancer metastasis; Immunotherapy; Thyroid cancer; Tumor microenvironment; Tumor-associated macrophages | Humans; Immunotherapy; Macrophages; Prognosis; Thyroid Neoplasms; Tumor Microenvironment; Tumor-Associated Macrophages; cytokine; histone deacetylase inhibitor; STAT3 protein; toll like receptor agonist; cancer chemotherapy; cancer immunotherapy; cancer staging; gene mutation; genetic susceptibility; human; immunocompetent cell; M1 tumor-associated macrophage; M2 tumor-associated macrophage; metastasis; monocyte; phagocytosis; polarization; Review; signal transduction; thyroid cancer; tumor associated leukocyte; tumor growth; tumor microenvironment; tumor promotion; tumor-associated macrophage; immunotherapy; macrophage; prognosis; thyroid tumor | English | 2023 | 2023-12 | 10.1007/s00262-023-03549-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Analysis of spatial perception and the influencing factors of attractions in Southwest China's ethnic minority areas: The case of Dali Bai Autonomous Prefecture | As standards of material living continue to improve and urbanization advances, an increasing number of remote ethnic minority areas are becoming tourist destinations. Understanding tourists' perceptions on a large scale is thus crucial for the development of the regional tourism industry. However, traditional research methods suffer from high costs, small sample sizes, and low efficiency, making it difficult to measure the spatial perception of remote areas on a large scale. This study constructs a research framework for spatial perception measurement of remote ethnic minority areas by collecting reviews data from Ctrip using spatiotemporal data calculation and the Geodetector model. We considered Dali Prefecture as an empirical case and analyzed tourists' perceptions of the area's attractions, the spatial distribution of the attractions, and the process of change in the explanatory power of their influencing factors over an eight-year period (2014-2021). The results indicated that the most visited attractions were concentrated in Dali City. The perception of humanistic resources (attractions) with historical value was the highest, followed by natural resources. The high perception of attractions was influenced by the level of tourism development, traffic accessibility and attractiveness, and had an increasing influence on tourists' perceptions over time. Additionally, changes in the mode of transportation from road to high-speed rail played an important role in the selection of tourist attractions. Conversely, the tourists paid relatively less attention to humanistic resources (e.g., national cultural heritage protection units and traditional villages). Our study provides a basis for the measurement of spatial perception in remote minority areas and can be used as a reference for tourism development planning in Dali Prefecture, thus promoting the sustainable development of tourism in the area. | Yin, Xiaoyan; Han, Xin; Jung, Taeyeol | Kyungpook Natl Univ, Dept Landscape Architecture, Daegu, South Korea | 58314079400; 57716224500; 55490551100 | jungty@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 18 | 6 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 2.9 | 23.5 | 0.94 | 2025-06-25 | 9 | 8 | TOURISM; CITY; INFORMATION; DESTINATION; TECHNOLOGY; EXPERIENCE; BEHAVIOR; PHOTOS | China; Ethnic and Racial Minorities; Ethnicity; Humans; Minority Groups; Space Perception; article; attention; calculation; China; depth perception; ethnic group; human; inheritance; natural resource; perception; sustainable development; tourism; velocity; village; China; depth perception; ethnicity; minority group | English | 2023 | 2023-06-13 | 10.1371/journal.pone.0285141 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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