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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Therapeutic Drug Monitoring of Adalimumab During Long-term Follow-up in Paediatric Patients With Crohn Disease | Objectives: We investigated the therapeutic drug monitoring of adalimumab (ADL) on clinical remission (CR) and mucosal healing (MH) rates in paediatric patients with Crohn disease (CD). Furthermore, long-term treatment efficacy of ADL in paediatric CD was evaluated through 3-year follow-up. Methods: We conducted a prospective study of 31 patients with CD who received ADL maintenance therapy and underwent endoscopic evaluation of MH and pharmacokinetic analysis. Patients in CR were identified based on Paediatric Crohn Disease Activity Index (PCDAI) scores less than 10. Patients with MH were identified based on Simple Endoscopic Scores for Crohn Disease (SES-CD) of less than 2. Results: At 4 months and 1 year of ADL treatment, 28 and 26 patients, respectively, were under CR; 13 and 17 patients, respectively, achieved MH. The median trough levels (TLs) of ADL were higher in patients in CR (7.6 +/- 3.5 mu g/mL) than in patients with active disease (5.1 +/- 2.2 mu g/mL). ADL TLs were significantly higher in patients who achieved MH than in those who did not (14.2 +/- 7.6 vs 7.8 +/- 5.2 mu g/mL). The optimal cut-point for predicting MH at 1 year of ADL treatment was 8.18 mu g/mL. During long-term follow-up, ADL TLs were stably maintained over 10 mu g/mL; not only CR and MH but also histologic remission was obtained at a high rate. ADL administration maintained a positive effect on growth during the maintenance period. Conclusions: ADL TLs were significantly higher in paediatric patients with CD who achieved CR or MH. ADL treatment showed long-term stable efficacy and positive effects on growth indicators. | Kim, Mi Jin; Kim, Eunsil; Kang, Ben; Choe, Yon Ho | Sungkyunkwan Univ, Samsung Med Ctr, Dept Pediat, Sch Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea | 康, 奔/JMQ-0812-2023; Kim, Mi Jin/GXH-9639-2022 | 56638815200; 57205500267; 57194823199; 21333712100 | i101016@skku.edu; | JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | J PEDIATR GASTR NUTR | 0277-2116 | 1536-4801 | 72 | 6 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;NUTRITION & DIETETICS;PEDIATRICS | 2021 | 3.355 | 31.2 | 0.25 | 2025-07-30 | 4 | 3 | adalimumab; Crohn disease; mucosal healing; therapeutic drug monitoring | INFLAMMATORY-BOWEL-DISEASE; INFLIXIMAB THERAPY; TOP-DOWN; NATURAL-HISTORY; LINEAR GROWTH; STEP-UP; CHILDREN; ADOLESCENTS; VALIDATION; MANAGEMENT | adalimumab; Crohn disease; mucosal healing; therapeutic drug monitoring | Adalimumab; Child; Crohn Disease; Drug Monitoring; Follow-Up Studies; Humans; Intestinal Mucosa; Prospective Studies; Severity of Illness Index; adalimumab; child; Crohn disease; drug monitoring; follow up; human; intestine mucosa; prospective study; severity of illness index | English | 2021 | 2021-06 | 10.1097/mpg.0000000000003070 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Transformation cavities with a narrow refractive index profile | Recently, gradient index cavities, or so-called transformation cavities, designed by conformal transformation optics, have been studied to support resonant modes with both high Q-factors and emission directionality. We propose a new, to the best of our knowledge, design method for transformation cavities to realize a narrower width of the refractive index profile, a great advantage in experimental implementations, without losing the benefits of conformal mapping. We study resonant modes with both high Q-factors and directional emission in newly designed transformation cavities, where the refractive index profile is 50% narrower than in previously proposed transformation cavities. By varying a system parameter with a fixed maximal value of the refractive index profile inside the cavity, the width of the refractive index profile narrows, the Q-factors become higher, and the near and far field patterns maintain their properties, namely, conformal whispering gallery modes and bidirectional emission, respectively. (C) 2021 Optical Society of America | Ryu, Jung-Wan; Cho, Jinhang | Inst Basic Sci IBS, Ctr Theoret Phys Complex Syst, Daejeon 34126, South Korea; Kyungpook Natl Univ, Digital Technol Res Ctr, Daegu 41566, South Korea | 12768616200; 18933904800 | jungwanryu@gmail.com; | OPTICS LETTERS | OPT LETT | 0146-9592 | 1539-4794 | 46 | 8 | SCIE | OPTICS | 2021 | 3.56 | 31.2 | 0.09 | 2025-07-30 | 2 | 2 | LUNEBURG LENS; CLOAK; METAMATERIALS; MODES | Birefringence; Conformal mapping; Q factor measurement; Whispering gallery modes; Conformal transformation; Directional emission; Emission directionality; Far-field patterns; Gradient indexes; Maximal values; Refractive index profiles; Resonant mode; article; refraction index; Refractive index | English | 2021 | 2021-04-15 | 10.1364/ol.422529 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Design and synthesis of acrylate and acrylamide substituted pyrimidinediones as potential PPO herbicides | PPO herbicides emerge to be widely use in the agricultural field and a focus of research to many scientists due to its environmentally-friendly properties. In lieu with this, this study presents acrylate and acrylamide substituted pyrimidinediones as PPO herbicide candidates. Most synthesized compounds exhibits herbicidal activities against both monocot and dicot weeds, especially, compound 5a which showed non-selective superior activity against the commercialized, Saflufenacil. Compound 5a was further tested for residual effect and showed promising results as shorter period is needed to cultivate the next crops. The synthesized acrylate and acrylamide substituted pyrimidinediones, especially, 5a could potentially be utilized in the development of commercial protoporphyrinogen oxidase inhibitors with further tests and studies. | Lee, Won Hyung; Kwon, Young Bin; Kim, Jung Hee; Lee, Kye Hwan; Maezono, Shizuka Mei Bautista; Choi, Jong-Soo; Seu, Young-Bae | Kyung Nong Co Ltd, Cent Res Inst, 34-14 Summeori Gil, Gyeongju Si 38175, Gyeongsangbuk D, South Korea; Kyungpook Natl Univ, Sch Life Sci & Biotechnol, Daegu 41566, South Korea | 57192303878; 57221291480; 57221292810; 57221283742; 57199500590; 55722465300; 6602236684 | ybseu@knu.ac.kr; | BIOORGANIC & MEDICINAL CHEMISTRY | BIOORGAN MED CHEM | 0968-0896 | 1464-3391 | 31 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;CHEMISTRY, ORGANIC | 2021 | 3.461 | 31.3 | 1.34 | 2025-07-30 | 21 | 22 | Pyrimidinediones; Herbicidal activity; Residual effect; PPO herbicides | Herbicidal activity; PPO herbicides; Pyrimidinediones; Residual effect | Acrylamide; Acrylates; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Herbicides; Molecular Structure; Protoporphyrinogen Oxidase; Pyrimidinones; Structure-Activity Relationship; acrylamide; acrylic acid; herbicide; protoporphyrinogen oxidase; pyrimidine derivative; pyrimidinedione; saflufenacil; unclassified drug; acrylamide; acrylic acid derivative; enzyme inhibitor; herbicide; protoporphyrinogen oxidase; pyrimidinone derivative; Article; chemical bond; chemical reaction; chemical structure; herbicidal activity; methylation; monocot; weed; chemistry; dose response; drug design; metabolism; structure activity relation; synthesis | English | 2021 | 2021-02-01 | 10.1016/j.bmc.2020.115959 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Quantitative CT image-based structural and functional changes during asthma acute exacerbations | Asthma acute exacerbations (AE) have been investigated using quantitative computed tomography (QCT)-based imaging metrics, but QCT has not yet been used to investigate a comprehensive set of imaging metrics during AE. This study aims to explore imaging features, captured both at segmental and parenchymal scales, during asthma AE compared with those in stable asthma (SA). Two sets of the QCT images at total lung capacity (TLC) and functional residual capacity (FRC) were captured for 14 subjects during asthma AE and in SA phase, respectively. We calculated airway wall thickness (WT), hydraulic diameter (D-h), and airway circularity (Cr) of the 36 segmental airways; percentage of functional small airway disease (fSAD%); percentage of emphysema; tissue fraction (beta(tiss)); and coefficient of variation of beta(tiss) (CV of beta(tiss)). We performed Spearman correlation tests for changes in QCT metrics and pulmonary function tests, measured in AE and SA. During asthma AE, structural metrics, that is, WT, D-h, and Cr, were not changed significantly. In functional metrics, CV of beta(tiss) at FRC indicating the heterogeneity of lung tissue distribution was significantly increased, whereas the mean of beta(tiss) at FRC did not change during AE. An increase of fSAD% during AE was most correlated with a decrease of forced expiratory volume in 1 s and forced vital capacity, especially in the lower lobes. This study demonstrates that the heterogeneous feature of beta(tiss )measured at lower lobes is more noticeable during asthma AE, compared with other traditional imaging metrics. This metric could be utilized to identify unique features during asthma AE. NEW & NOTEWORTHY Using two sets of inspiration and expiration images, the difference of segmental airway structure and parenchymal lung function is assessed by comparing the QCT images during asthma acute exacerbations with those in stable asthma. This study also introduces a useful application of an imaging-based metric, estimating the heterogeneity of tissue distribution. This could be a phenotype for the asthma acute exacerbation. | Park, Joonwoo; Kim, Sujeong; Lim, Jae-Kwang; Jin, Kwang Nam; Yang, Min Suk; Chae, Kum Ju; Jin, Gong Yong; Kim, Tae-Bum; Kim, Hee-Kyoo; Lee, Kyeong Eun; Lee, Chang Hyun; Choi, Sanghun | Kyungpook Natl Univ, Coll Engn, Sch Mech Engn, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Radiol, Daegu, South Korea; Seoul Natl Univ, Dept Radiol, Seoul Metropolitan Govt, Boramae Med Ctr, Seoul, South Korea; Seoul Natl Univ, Dept Internal Med, Seoul Metropolitan Govt, Boramae Med Ctr, Seoul, South Korea; Chonbuk Natl Univ, Inst Med Sci, Dept Radiol, Res Inst Clin Med,Biomed Res Inst,Chonbuk Natl Un, Jeonju, South Korea; Univ Ulsan, Asan Med Ctr, Dept Allergy & Clin Immunol, Coll Med, Seoul, South Korea; Kosin Univ, Coll Med, Dept Internal Med, Gospel Hosp, Busan, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Dept Stat, Daegu, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Dept Radiol, Seoul, South Korea | Kim, Jong/J-2749-2012; Kim, Ju-Hyoung/N-1450-2019; Kim, Chaeyoung/GPW-6531-2022; Lee, Su Hwan/R-6161-2019; Choi, Sanghun/AGS-7430-2022; Kim, Tae-Hee/AAN-9079-2021 | 57255273200; 36666447400; 55515341400; 22035230800; 7404927140; 57195310676; 55663719500; 57206927697; 55910350900; 56041259000; 57196253438; 55847101000 | changhyun.lee@snu.ac.kr;s-choi@knu.ac.kr; | JOURNAL OF APPLIED PHYSIOLOGY | J APPL PHYSIOL | 8750-7587 | 1522-1601 | 131 | 3 | SCIE | PHYSIOLOGY;SPORT SCIENCES | 2021 | 3.881 | 31.3 | 0.92 | 2025-07-30 | 10 | 10 | asthma acute exacerbations; coefficient of variation; functional heterogeneity; stable asthma; tissue fraction | AIRWAY RESPONSIVENESS; LUNG-FUNCTION; METHACHOLINE; VENTILATION; TOMOGRAPHY; REGISTRATION; VARIABILITY; PHENOTYPES; HISTAMINE; ATOPY | Asthma acute exacerbations; Coefficient of variation; Functional heterogeneity; Stable asthma; Tissue fraction | Asthma; Forced Expiratory Volume; Humans; Lung; Pulmonary Disease, Chronic Obstructive; Tomography, X-Ray Computed; asthma; chronic obstructive lung disease; diagnostic imaging; forced expiratory volume; human; lung; x-ray computed tomography | English | 2021 | 2021-09 | 10.1152/japplphysiol.00743.2020 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Association of plasma concentrations of oxytocin, vasopressin, and serotonin with docility and friendliness of horses | Oxytocin (OXT) and vasopressin (AVP) have been associated with social interaction and affiliative behavior in animals. Additionally, AVP is known to affect socially aggressive behavior. In addition, serotonin has an association with aggressive behaviors. The objectives of this study were (1) to evaluate OXT, AVP, and serotonin concentrations in the plasma of horses of different breeds, sexes, and ages and (2) to determine if the neurotransmitters are associated with horse docility and friendliness. This study was performed at Sangju International Equestrian Center. Blood samples were collected from 23 horses, including 6 Thoroughbreds (11 to 18 yr), 6 Warmbloods (15 to 26 yr), 6 ponies (8 to 17 yr), and 5 Quarter Horses (4 to 12 yr). The group of horses consisted of 13 mares and 10 geldings. The plasma concentrations of OXT and AVP were measured by enzyme-linked immunosorbent assay, and the serum concentration of serotonin was measured by highperformance liquid chromatography. The characteristics of each horse were surveyed by 3 horse trainers. The effects of breed, sex, and age on the concentration of each neurotransmitter were assessed by a 3-way ANOVA with LSD post-hoc analysis. Linear regression analysis was performed to determine if the concentration of neurotransmitters is related to the docility and friendliness of horses. As a result, the concentrations of OXT and AVP did not vary with the breed, sex, or age of horses. However, the serotonin concentration varied depending on the breed and age of horses. Interestingly, there was a trend toward the existence of a correlation between docility and OXT in Thoroughbred horses. However, AVP and serotonin concentrations had no correlation with the docility and friendliness of horses. In conclusion, the docility and friendliness of Thoroughbred might be related with the blood OXT concentration. (C) 2020 Elsevier Inc. All rights reserved. | Lee, Geumhui; Yoon, Minjung | Kyungpook Natl Univ, Dept Anim & Biotechnol Sci, Sangju 37224, South Korea; Kyungpook Natl Univ, Dept Horse Compan & Wild Anim Sci, Sangju 37224, South Korea | 57191860695; 22137296500 | mjyoonemail@gmail.com; | DOMESTIC ANIMAL ENDOCRINOLOGY | DOMEST ANIM ENDOCRIN | 0739-7240 | 1879-0054 | 74 | SCIE | AGRICULTURE, DAIRY & ANIMAL SCIENCE;ENDOCRINOLOGY & METABOLISM | 2021 | 2.566 | 31.5 | 1.2 | 2025-07-30 | 10 | 10 | Horses; Oxytocin; Serotonin; Vasopressin; Docility; Friendliness | AGGRESSION; TRYPTOPHAN; BEHAVIOR; TEMPERAMENT; BRAIN; PIGS | Docility; Friendliness; Horses; Oxytocin; Serotonin; Vasopressin | oxytocin; serotonin; vasopressin; animal behavior; Article; blood sampling; breed difference; controlled study; Dutch Warmblood; enzyme linked immunosorbent assay; female; gelding; grooming; high performance liquid chromatography; horse breed; male; mare; nonhuman; oxytocin blood level; pony; Quarter horse; serotonin blood level; sex difference; social interaction; temperament; Thoroughbred horse; vasopressin blood level | English | 2021 | 2021-01 | 10.1016/j.domaniend.2020.106482 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Enabling and Cultivating Wiser Consumption: The Roles of Marketing and Public Policy | Contemporary consumers, societies, and ecologies face many challenges to well-being. Consumer researchers have responded with new attention to what engenders happiness and flourishing, particularly as a function of wiser consumption. Consumer wisdom has been conceptualized as the pursuit of well-being through the application of six interrelated dimensions: responsibility, purpose, flexibility, perspective, reasoning, and sustainability. However, up to now, the roles of marketing management and government policies with respect to enabling and supporting consumer wisdom have not been thoroughly and systematically considered. To do this, the authors adopt an integrative approach based on a range of theoretical and empirical insights from both consumer research and wisdom research in the social sciences. They weave these insights into the stages of an expanded version of the circular economy model of the value cycle, within which they also include the traditional four Ps of the marketing mix. This approach allows the authors to identify how marketing practices and public policies can enable and support consumer wisdom, resulting in advancements to well-being and the common good, as well as restorations to the missions and reputations of business and government. | Ozanne, Lucie K.; Stornelli, Jason; Luchs, Michael G.; Mick, David Glen; Bayuk, Julia; Birau, Mia; Chugani, Sunaina; Fransen, Marieke L.; Herziger, Atar; Komarova, Yuliya; Minton, Elizabeth A.; Reshadi, Farnoush; Sullivan-Mort, Gillian; Trujillo, Carlos; Bae, Hyeyoon; Kaur, Tavleen; Zuniga, Miguel | Univ Canterbury, Christchurch, New Zealand; Oregon State Univ, Corvallis, OR 97331 USA; William & Mary, Williamsburg, VA USA; Univ Virginia, Charlottesville, VA 22903 USA; Univ Delaware, Newark, DE 19716 USA; Emlyon Business Sch, Ecully, France; San Diego State Univ, San Diego, CA 92182 USA; Univ Amsterdam, Amsterdam, Netherlands; Ohio State Univ, Columbus, OH 43210 USA; Fordham Univ, Bronx, NY 10458 USA; Univ Wyoming, Laramie, WY 82071 USA; Worcester Polytech Inst, Worcester, MA 01609 USA; La Trobe Univ, Bundoora, Vic, Australia; Univ los Andes, Bogota, Colombia; Kyungpook Natl Univ, Daegu, South Korea; Morgan State Univ, Baltimore, MD 21239 USA | Bae, Hyeyoon/HQZ-4381-2023; Herziger, Atar/S-5255-2019; Trujillo, Carlos Andres/AAE-8224-2022; Reshadi, Farnoush/AAQ-6938-2021; Trujillo, Carlos Andres/E-9880-2013 | lucie.ozanne@canterbury.ac.nz;jason.stornelli@oregonstate.edu;Michael.luchs@mason.wm.edu;dgm9t@comm.virginia.edu;jbayuk@udel.edu;m.miabirau@gmail.com;schugani@sdsu.edu;m.l.fransen@uva.nl;herziger.1@osu.edu;ykomarova@fordham.edu;eminton@uwyo.edu;freshadi@wpi.edu;g.sullivan-mort@latrobe.edu.au;ctrujill@uniandes.edu.co;nicola7@knu.ac.kr;tavleendhandra@gmail.com;Miguel.Zuniga@morgan.edu; | JOURNAL OF PUBLIC POLICY & MARKETING | J PUBLIC POLICY MARK | 0743-9156 | 1547-7207 | 40 | 2 | SSCI | BUSINESS | 2021 | 6.435 | 31.5 | 29 | consumer wisdom; marketing management; public policies; value cycle; well-being | WISDOM; NEUROBIOLOGY; CHALLENGES; RESPONSES; SYSTEM; WILL | English | 2021 | 2021-04 | 10.1177/0743915620975407 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Overexpression of hepatic serum amyloid A1 in mice increases IL-17-producing innate immune cells and decreases bone density | Serum amyloid A (SAA) is an acute-phase protein produced primarily in the liver that plays a key role in both the initiation and maintenance of inflammation. Rapidly secreted SAA induces neutrophilia at inflammatory sites, initiating inflammation and inducing the secretion of various cytokines, including TNF-a, IL-6, and IL-17. IL-17 is expressed in several inflammatory cells, including innate immune cells such as.dT cells, ILC3 cells, and neutrophils. Increased IL-17 levels exacerbate various inflammatory diseases. Among other roles, IL-17 induces bone loss by increasing receptor activator of nuclear factor-.B ligand (RANKL) secretion, which stimulates osteoclast differentiation. Several studies have demonstrated that chronic inflammation induces bone loss, suggesting a role for SAA in bone health. To test this possibility, we observed an increase in IL-17-producing innate immune cells, neutrophils, and.dT cells in these mice. In 6-month-old animals, we detected increased osteoclast-related gene expression and IL17 expression in bone lysates. We also observed an increase in neutrophils that secreted RANKL in the bone marrow of TG mice. Finally, we demonstrated decreased bone mineral density in these transgenic (TG) mice. Our results revealed that the TG mice have increased populations of IL-17-producing innate immune cells,.dT cells, and neutrophils in TG mice. We additionally detected increased RANKL and IL-17 expression in the bone marrow of 6-month-old TG mice. Furthermore, we confirmed significant increases in RANKL-expressing neutrophils in TG mice and decreased bone mineral density. Our results provide evidence that chronic inflammation induced by SAA1 causes bone loss via IL-17-secreting innate immune cells. | Choi, Minjee; Park, Song; Yi, Jun Koo; Kwon, Wookbong; Jang, Soyoung; Kim, Si-Yong; Yu, Wookyung; Kim, Myoung Ok; Ryoo, Zae Young; Choi, Seong-Kyoon | DGIST, Core Prot Resources Ctr, Daegu, South Korea; DGIST, Dept Brain & Cognit Sci, Daegu, South Korea; Gyeongsangbukdo Livestock Res Inst, Yeongju Si, South Korea; DGIST, Div Biotechnol, Daegu, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 KNU Creat Biores Grp 4, Daegu, South Korea; Kyungpook Natl Univ, Sch Anim Sci Biotechnol, Sangju Si, South Korea | ; Yi, Junkoo/JBR-8507-2023; RYOO, ZAEYOUNG/AAQ-1573-2020 | 56374516800; 57139047900; 56182537200; 57139843600; 57139360300; 57212197751; 56410212300; 8934745900; 16937104900; 55505432500 | jaewoong64@hanmail.net;cskbest@dgist.ac.kr; | JOURNAL OF BIOLOGICAL CHEMISTRY | J BIOL CHEM | 1083-351X | 296 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2021 | 5.485 | 31.5 | 1.03 | 2025-07-30 | 15 | 16 | NECROSIS-FACTOR-ALPHA; RECEPTOR; NEUTROPHILIA; DISEASE; WNT | Animals; Bone Density; Gene Expression Regulation; Immunity, Innate; Interleukin-17; Intraepithelial Lymphocytes; Liver; Mice; Neutrophils; Osteoclasts; Serum Amyloid A Protein; Gene expression; Glycoproteins; Mammals; Pathology; Proteins; interleukin 17; osteoclast differentiation factor; protein serum amyloid A1; serum amyloid A; unclassified drug; interleukin 17; serum amyloid A; Acute phase proteins; Bone mineral density; Chronic inflammation; Inflammatory cells; Inflammatory disease; Nuclear factor kappaB; Osteoclast differentiation; Receptor activator; animal cell; animal experiment; animal model; animal tissue; Article; bone density; bone marrow; chronic inflammation; controlled study; cytokine production; cytokine release; gene expression; immunocompetent cell; innate immunity; mouse; neutrophil; nonhuman; osteoclast; osteolysis; priority journal; protein expression; animal; biosynthesis; gene expression regulation; genetics; immunology; intraepithelial lymphocyte; liver; metabolism; Cytology | English | 2021 | 2021 (JAN-JUN) | 10.1016/j.jbc.2021.100595 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Oxytocin receptor expression in stallion testes and epididymides | Endocrine, paracrine, and autocrine factors orchestrate the development and physiology of the stallion reproductive system. Oxytocin (OXT) is one of the critical endocrine, paracrine, and autocrine factors for the male reproductive system. Previous studies have investigated OXT receptor (OXTR) expression in testes and epididymides, including humans, marmosets, macaques, swine, and sheep. This study aimed to explore (1) OXTR localization in the testes and epididymides and (2) the seasonal modification of OXTR expression in the testes. Adult stallion testis and epididymis samples were prepared using routine castration procedures. Reverse-transcription PCR was performed to detect the presence of OXTR messenger RNA (mRNA) in the testes. Western blot procedure was performed to confirm the cross-reactivity of OXTR antibody to horse OXTR. Immunohistochemistry was performed to detect OXTR protein expression in the testes and epididymides. Oxytocin receptor mRNA was detected in the stallion testes. The OXTR protein band was observed at 55 kDa. Interestingly, the relative intensity of the OXTR protein band varied between nonbreeding and breeding season. The OXTR protein level in the testes collected during the breeding season was higher than that during the nonbreeding season. Oxytocin receptor localization was observed in the cytoplasm of Type A spermatogonia and spermatid. Oxytocin receptor protein expression was also observed in the cytoplasmic area of Leydig cells and the membrane of the seminiferous tubules. The cytoplasm of principal and basal cells in the caput, corpus, and cauda was also immunolabeled with OXTR antibody. In conclusion, based on the expression of OXTR in tissues of testes and epididymides, OXT-OXTR system may be a critical factor for stallion testicular and epididymal function. In addition, according to the seasonal alteration of intensity, the OXT-OXTR system may be associated with seasonal changes in the reproductive system in stallions. (C) 2020 Elsevier Inc. All rights reserved. | Jung, Y.; Yoon, M. | Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; Kyungpook Natl Univ, Dept Horse Compan & Wild Anim Sci, Sangju 37224, South Korea | 57219279028; 59774100300 | mjyoonemail@gmail.com; | DOMESTIC ANIMAL ENDOCRINOLOGY | DOMEST ANIM ENDOCRIN | 0739-7240 | 1879-0054 | 74 | SCIE | AGRICULTURE, DAIRY & ANIMAL SCIENCE;ENDOCRINOLOGY & METABOLISM | 2021 | 2.566 | 31.5 | 1.47 | 2025-07-30 | 12 | 11 | Oxytocin receptor; Stallion; Testis; Epididymis | ARGININE-VASOPRESSIN; SEMINAL QUALITY; LEYDIG-CELLS; IN-VITRO; CONTRACTILITY; LOCALIZATION; OUTPUT; SEASON; FLUID | Epididymis; Oxytocin receptor; Stallion; Testis | Animals; Epididymis; Gene Expression Regulation; Horses; Male; Receptors, Oxytocin; Seasons; Spermatogonia; Testis; beta actin; glyceraldehyde 3 phosphate dehydrogenase; oxytocin receptor; oxytocin receptor; adult; animal tissue; antibody labeling; Article; castration; controlled study; cross reaction; cytoplasm; epididymal tissue; epididymis; gene expression; immunohistochemistry; Leydig cell; male; nonhuman; protein expression; protein localization; reverse transcription polymerase chain reaction; seminiferous tubule; spermatid; spermatogonium; stallion; testis tissue; Western blotting; animal; epididymis; gene expression regulation; genetics; horse; metabolism; physiology; season; testis | English | 2021 | 2021-01 | 10.1016/j.domaniend.2020.106562 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | The expression of androstenone receptor (OR7D4) in vomeronasal organ and olfactory epithelium of horses | Androstenone is the first mammalian steroidal pheromone to be identified. Pheromones are chemicals that animals use to communicate within a species. Pheromone detections are related to vomeronasal organ (VNO) and olfactory epithelium (OE) in mammals. Olfactory Receptor Family 7 Subfamily D Member 4 (OR7D4) is an odorant receptor that responds to androstenone. Several studies indicated that spray with androstenone changes behaviors of the boar and dogs. However, the expression of OR7D4 in VNO and OE was not reported in mammals except human. Thus, the main objectives of this study were to investigate the expression of OR7D4 in VNO and OE of horses. Tissue samples were collected from the VNO and nasal cavity of 6 thoroughbred horses. The presence of OR7D4 gene was investigated with reverse transcription-polymerase chain reaction. The expression of OR7D4 was determined using Western blot and immunofluorescence. As a result, the bands for OR7D4 were observed at approximately 462 bp. The protein band of OR7D4 of VNO and OE was detected at 38 kDa. Immunofluorescence result showed that the cilia and cytoplasm of olfactory receptor cells of VNO and nasal cavity tissues were immunolabeled with OR7D4 antibody. The intensity of OR7D4 protein bands in the ventral region of the ethmoidal concha tissues was not significantly different between mares and geldings. In conclusion, thoroughbred horses are capable of androstenone perception through OR7D4 expressed in the VNO and OE. (c) 2020 Elsevier Inc. All rights reserved. | Choi, Y.; Yoon, M. | Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; Kyungpook Natl Univ, Dept Horse Compan & Wild Anim Sci, Sangju 37224, South Korea | 57208551604; 59774100300 | mjyoonemail@gmail.com; | DOMESTIC ANIMAL ENDOCRINOLOGY | DOMEST ANIM ENDOCRIN | 0739-7240 | 1879-0054 | 74 | SCIE | AGRICULTURE, DAIRY & ANIMAL SCIENCE;ENDOCRINOLOGY & METABOLISM | 2021 | 2.566 | 31.5 | 0.94 | 2025-07-30 | 7 | 7 | OR7D4; Androstenone; Horses; Vomeronasal organ; Olfactory epithelium | Androstenone; Horses; Olfactory epithelium; OR7D4; Vomeronasal organ | Animals; Female; Gene Expression Regulation; Horses; Male; Olfactory Mucosa; Polymerase Chain Reaction; Receptors, Odorant; Vomeronasal Organ; olfactory receptor family 7 subfamily d member 4; olfactory receptor family 7 subfamily d member 4 antibody; pheromone receptor; receptor antibody; unclassified drug; animal tissue; antibody labeling; Article; controlled study; cross reaction; female; gelding; immunofluorescence test; immunohistochemistry; male; mare; molecular weight; nonhuman; nose cavity; olfactory epithelium; olfactory receptor neuron; reverse transcription polymerase chain reaction; vomeronasal organ; Western blotting; animal; gene expression regulation; genetics; horse; metabolism; olfactory mucosa; olfactory receptor; physiology; polymerase chain reaction; veterinary medicine; vomeronasal organ | English | 2021 | 2021-01 | 10.1016/j.domaniend.2020.106535 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Classification of MR-Detected Additional Lesions in Patients With Breast Cancer Using a Combination of Radiomics Analysis and Machine Learning | ObjectiveThis study was conducted in order to investigate the feasibility of using radiomics analysis (RA) with machine learning algorithms based on breast magnetic resonance (MR) images for discriminating malignant from benign MR-detected additional lesions in patients with primary breast cancer. Materials and MethodsOne hundred seventy-four MR-detected additional lesions (benign, n = 86; malignancy, n = 88) from 158 patients with ipsilateral primary breast cancer from a tertiary medical center were included in this retrospective study. The entire data were randomly split to training (80%) and independent test sets (20%). In addition, 25 patients (benign, n = 21; malignancy, n = 15) from another tertiary medical center were included for the external test. Radiomics features that were extracted from three regions-of-interest (ROIs; intratumor, peritumor, combined) using fat-saturated T1-weighted images obtained by subtracting pre- from postcontrast images (SUB) and T2-weighted image (T2) were utilized to train the support vector machine for the binary classification. A decision tree method was utilized to build a classifier model using clinical imaging interpretation (CII) features assessed by radiologists. Area under the receiver operating characteristic curve (AUROC), accuracy, sensitivity, and specificity were used to compare the diagnostic performance. ResultsThe RA models trained using radiomics features from the intratumor-ROI showed comparable performance to the CII model (accuracy, AUROC: 73.3%, 69.6% for the SUB RA model; 70.0%, 75.1% for the T2 RA model; 73.3%, 72.0% for the CII model). The diagnostic performance increased when the radiomics and CII features were combined to build a fusion model. The fusion model that combines the CII features and radiomics features from multiparametric MRI data demonstrated the highest performance with an accuracy of 86.7% and an AUROC of 91.1%. The external test showed a similar pattern where the fusion models demonstrated higher levels of performance compared with the RA- or CII-only models. The accuracy and AUROC of the SUB+T2 RA+CII model in the external test were 80.6% and 91.4%, respectively. ConclusionOur study demonstrated the feasibility of using RA with machine learning approach based on multiparametric MRI for quantitatively characterizing MR-detected additional lesions. The fusion model demonstrated an improved diagnostic performance over the models trained with either RA or CII alone. | Lee, Hyo-jae; Nguyen, Anh-Tien; Ki, So Yeon; Lee, Jong Eun; Do, Luu-Ngoc; Park, Min Ho; Lee, Ji Shin; Kim, Hye Jung; Park, Ilwoo; Lim, Hyo Soon | Chonnam Natl Univ Hosp, Dept Radiol, Gwangju, South Korea; Chonnam Natl Univ, Hwasun Hosp, Dept Radiol, Gwangju, South Korea; Chonnam Natl Univ, Dept Radiol, Gwangju, South Korea; Chonnam Natl Univ, Dept Surg, Dept Surg, Gwangju, South Korea; Chonnam Natl Univ Hwasun Hosp, Dept Pathol, Gwangju, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Radiol, Daegu, South Korea; Chonnam Natl Univ, Dept Artificial Intelligence Convergence, Gwangju, South Korea | 57194715631; 57650894400; 56332655800; 57196009389; 56073444700; 57208427911; 55665972300; 57203506201; 55456476100; 55666764800 | ipark@jnu.ac.kr;nicolas-hs@hanmail.net; | FRONTIERS IN ONCOLOGY | FRONT ONCOL | 2234-943X | 11 | SCIE | ONCOLOGY | 2021 | 5.738 | 31.6 | 0.55 | 2025-07-30 | 10 | 10 | breast neoplasms; magnetic resonance imaging; machine learning; radiomics; ultrasonography | 2ND-LOOK ULTRASOUND; TARGETED ULTRASOUND; IMAGING ASSESSMENT; TEXTURE ANALYSIS; HETEROGENEITY; TUMOR; STANDARDIZATION; GUIDELINE; FEATURES | breast neoplasms; machine learning; magnetic resonance imaging; radiomics; ultrasonography | estrogen receptor; adult; Article; binary classification; breast cancer; cancer patient; clinical assessment; controlled study; decision tree; diagnostic test accuracy study; echography; feasibility study; female; human; immunohistochemistry; lymph vessel metastasis; machine learning; major clinical study; mammography; multiparametric magnetic resonance imaging; nuclear magnetic resonance; personalized medicine; quantitative analysis; radiologist; radiomics; receiver operating characteristic; retrospective study; support vector machine; vacuum assisted biopsy | English | 2021 | 2021-12-02 | 10.3389/fonc.2021.744460 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | Targeting the Stroma in the Management of Pancreatic Cancer | Pancreatic cancer (PC) presents extremely aggressive tumours and is associated with poor survival. This is attributed to the unique features of the tumour microenvironment (TME), which is known to create a dense stromal formation and poorly immunogenic condition. In particular, the TME of PC, including the stromal cells and extracellular matrix, plays an essential role in the progression and chemoresistance of PC. Consequently, several promising agents that target key components of the stroma have already been developed and are currently in multiple stages of clinical trials. Therefore, the authors review the latest available evidence on novel stroma-targeting approaches, highlighting the potential impact of the stroma as a key component of the TME in PC. | Edwards, Penelope; Kang, Byung Woog; Chau, Ian | Royal Marsden Hosp, Dept Med, London, England; Kyungpook Natl Univ, Sch Med, Kyungpook Natl Univ Hosp, Dept Oncol Hematol, Daegu, South Korea | ; Chau, Ian/ABC-2023-2020 | 57212421484; 28567838500; 14526721100 | ian.chau@rmh.nhs.uk; | FRONTIERS IN ONCOLOGY | FRONT ONCOL | 2234-943X | 11 | SCIE | ONCOLOGY | 2021 | 5.738 | 31.6 | 0.58 | 2025-07-30 | 18 | 17 | pancreatic cancer; stroma; immune checkpoint inhibition (ICI); hyaluronic acid; hedgehog (Hh); bruton kinase inhibitor; SPARC | PHASE-III TRIAL; PACLITAXEL PLUS GEMCITABINE; TISSUE GROWTH-FACTOR; NAB-PACLITAXEL; TUMOR MICROENVIRONMENT; MONOCLONAL-ANTIBODY; 1ST-LINE TREATMENT; DUCTAL ADENOCARCINOMA; STELLATE CELL; DOUBLE-BLIND | bruton kinase inhibitor; hedgehog (Hh); hyaluronic acid; immune checkpoint inhibition (ICI); pancreatic cancer; SPARC; stroma | English | 2021 | 2021-07-14 | 10.3389/fonc.2021.691185 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | The Prognosis and Oncological Predictor of Urachal Carcinoma of the Bladder: A Large Scale Multicenter Cohort Study Analyzed 203 Patients With Long Term Follow-Up | Aim This study evaluated the prognosis and survival predictors for bladder urachal carcinoma (UC), based on large scale multicenter cohort with long term follow-up database. Methods A total 203 patients with bladder UC treated at 19 hospitals were enrolled. Clinical parameters on carcinoma presentation, diagnosis, and therapeutic methods were reviewed for the primary cancer and for all subsequent recurrences. The stage of UC was stratified by Mayo and Sheldon pathological staging system. Oncological outcomes and the possible clinicopathological parameters associated with survival outcomes were investigated. Results The mean age of the patients was 54.2 years. Among the total of 203 patients, stages I, II, III, and IV (Mayo stage) were 48 (23.8%), 108 (53.5%), 23 (11.4%), and 23 (11.4%), respectively. Gross hematuria and bladder irritation symptoms were the two most common initial symptoms. The mean follow-up period was 65 months, and 5-year overall survival rates (OS), cancer-specific survival rates (CSS), and recurrence-free survival rates (RFS) were 88.3, 83.1, and 63.9%, respectively. For the patients with Mayo stage >= III, OS, CSS, and RFS were significantly decreased to 38.0, 35.2, and 28.4%, respectively. The higher pathological stage (Mayo stage >= III, Sheldon stage >= IIIc), positive surgical margin (PSM), and positive lymphovascular invasion (PLM) were independent predictors of shorter OS, CSS, and RFS. Conclusion The pathological stage, PSM, and PLM were significantly associated with the survival of UC patients, emphasizing an importance of the complete surgical resection of tumor lesion. | Yu, Young Dong; Ko, Young Hwii; Kim, Jong Wook; Jung, Seung Il; Kang, Seok Ho; Park, Jinsung; Seo, Ho Kyung; Kim, Hyung Joon; Jeong, Byong Chang; Kim, Tae-Hwan; Choi, Se Young; Nam, Jong Kil; Ku, Ja Yoon; Joo, Kwan Joong; Jang, Won Sik; Yoon, Young Eun; Yun, Seok Joong; Hong, Sung-Hoo; Oh, Jong Jin | CHA Univ, Bundang CHA Hosp, Dept Urol, Coll Med, Seongnam, South Korea; Yeungnam Univ Hosp, Dept Urol, Daegu, South Korea; Korea Univ, Dept Urol, Coll Med, Seoul, South Korea; Chonnam Natl Univ, Sch Med, Dept Urol, Gwangju, South Korea; Korea Univ, Sch Med, Dept Urol, Seoul, South Korea; Eulji Univ, Sch Med, Eulji Univ Hosp, Dept Urol, Daejeon, South Korea; Ctr Urol Canc Hosp, Dept Urol, Goyang, South Korea; Konyang Univ, Coll Med, Myunggok Med Res Inst, Dept Urol, Daejeon, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Urol, Seoul, South Korea; Kyungpook Natl Univ, Coll Med, Dept Urol, Daegu, South Korea; Chung Ang Univ, Chung Ang Univ Hosp, Coll Med, Dept Urol, Seoul, South Korea; Pusan Natl Univ, Yangsan Hosp, Dept Urol, Pusan, South Korea; Pusan Natl Univ Hosp, Dept Urol, Busan, South Korea; Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Urol, Seoul, South Korea; Yonsei Univ, Coll Med, Urol Sci Inst, Dept Urol,Severance Hosp, Seoul, South Korea; Hanyang Univ Hosp, Dept Urol, Seoul, South Korea; Chungbuk Natl Univ, Chungbuk Natl Univ Hosp, Coll Med, Dept Urol, Cheongju, South Korea; Seoul St Marys Hosp, Dept Urol, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Urol, Seongnam, South Korea; Seoul Natl Univ, Coll Med, Dept Urol, Seoul, South Korea | Kim, Hyung Joon/F-6497-2013; Kim, Jong Wook/HTP-6808-2023; Kim, Siwon/KHX-9078-2024; Choi, Se Young/AEB-2770-2022; Yoon, Youngeun/HOC-1137-2023; Ko, Young Hwii/GRX-0718-2022 | 56083697500; 25723368800; 57192647677; 7403677192; 7405684686; 56900085500; 8418841600; 57202103629; 7102237943; 57797823600; 57209856147; 8653467500; 55373044600; 8363552700; 56646805300; 55965389800; 16302421300; 37030299600; 24468588100 | bebsuzzang@naver.com; | FRONTIERS IN ONCOLOGY | FRONT ONCOL | 2234-943X | 11 | SCIE | ONCOLOGY | 2021 | 5.738 | 31.6 | 0.62 | 2025-07-30 | 15 | 12 | urachal carcinoma; bladder; survival rate; surgical margin; lymphovascular invasion | SURVIVAL; ADENOCARCINOMA; MANAGEMENT; CANCER | bladder; lymphovascular invasion; surgical margin; survival rate; urachal carcinoma | CA 19-9 antigen; carcinoembryonic antigen; epidermal growth factor receptor; adult; Article; bladder carcinoma; bladder irritation; cancer adjuvant therapy; cancer chemotherapy; cancer prognosis; cancer specific survival; cancer staging; cancer survival; cell survival; cohort analysis; computer assisted tomography; controlled study; cystectomy; follow up; hematuria; histology; histopathology; hospitalization; human; human tissue; immunohistochemistry; major clinical study; middle aged; multicenter study; nuclear magnetic resonance imaging; outcome assessment; overall survival; pathology; positron emission tomography; prognosis; questionnaire; recurrence free survival; stomach cancer; survival rate; tumor volume | English | 2021 | 2021-05-31 | 10.3389/fonc.2021.683190 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Validation of the GenesWell BCT Score in Young Asian Women With HR+/HER2-Early Breast Cancer | Background: The prognostic or predictive value of commonly used multigene assays in young patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) early breast cancer is unclear. In this study, we assessed the prognostic value of the GenesWell BCT assay according to age group. Methods: We identified patients with pN0-1, HR+/HER2- breast cancer in a prospective cohort of women who underwent surgery between 2005 and 2017. The GenesWell BCT assay was performed on tissue samples from selected patients. Distant metastasis-free survival (DMFS) and disease-free survival (DFS) were compared between the risk groups assigned by the BCT score. Results: A total of 712 patients were eligible for analysis. The median follow-up time was 7.47 years. The BCT score was prognostic in patients aged 50 years (n = 308). In both age groups, the 10-year DMFS and DFS rates for patients classified as high risk by the BCT score were significantly lower than those for patients classified as low risk. A multivariate analysis revealed that the BCT score was an independent prognostic factor for DFS in patients aged 50 years. Conclusion: The BCT score could be used to identify low-risk patients who will not benefit from adjuvant chemotherapy to treat HR+/HER2- early breast cancer regardless of age. A further prospective study to assess the prognostic and predictive value of the BCT score is required. | Kwon, Mi Jeong; Ryu, Jai Min; Cho, Soo Youn; Nam, Seok Jin; Kim, Seok Won; Lee, Jeeyeon; Lee, Soo Jung; Park, Ji-Young; Park, Ho Yong; Hong, Sungjun; Kim, Kyunga; Han, Jinil; Moon, Youngho; Shin, Young Kee; Lee, Jeong Eon | Kyungpook Natl Univ, Coll Pharm, Vessel Organ Interact Res Ctr, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Surg, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pathol & Translat Genom, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Surg, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Oncol Hematol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Pathol, Daegu, South Korea; Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol, Dept Digital Hlth, Seoul, South Korea; Samsung Med Ctr, Res Inst Future Med, Stat & Data Ctr, Seoul, South Korea; Gencurix Inc, R&D Ctr, Seoul, South Korea; Seoul Natl Univ, Res Inst Pharmaceut Sci, Lab Mol Pathol & Canc Genom, Seoul, South Korea; Seoul Natl Univ, Coll Pharm, Seoul, South Korea; Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Dept Mol Med & Biopharmaceut Sci, Seoul, South Korea | Lee, Jeeyun/I-7171-2015; Lee, Jong-Mok/KVY-9550-2024; PARK, JUN-YOUNG/P-5981-2015; Park, Jae Yong/ISS-5916-2023; Hong, Sung Noh/MTB-0511-2025; Shin, Young/C-8929-2011; Kim, Seok-Mo/AAK-5898-2020; Kim, Kyunga/LCL-2839-2024; Kim, Jee/J-5441-2012 | 35278164800; 57158270000; 7404885257; 7402276023; 55949767700; 37079213100; 57203597252; 57210160197; 56564377200; 57210552646; 12767292800; 56982070700; 57224708174; 26428533000; 57200181799 | paojlus@hanmail.net; | FRONTIERS IN ONCOLOGY | FRONT ONCOL | 2234-943X | 11 | SCIE | ONCOLOGY | 2021 | 5.738 | 31.6 | 0.14 | 2025-07-30 | 2 | 2 | GenesWell BCT assay; BCT score; prognostic value; predictive value; young breast cancer patients; HR+/HER2-early breast cancer | GENE-EXPRESSION; RISK; CHEMOTHERAPY | BCT score; GenesWell BCT assay; HR+/HER2− early breast cancer; predictive value; prognostic value; young breast cancer patients | butyrophilin subfamily 3 member a2; epidermal growth factor receptor; epidermal growth factor receptor 2; estrogen receptor; forkhead box protein M1; Ki 67 antigen; marker of proliferation Ki 67; progesterone receptor; protein; ribonucleotide reductase regulatory subunit m2; topoisomerase 2 alpha gene; ubiquilin 1; ubiquitin conjugating enzyme E2; unclassified drug; adjuvant chemotherapy; adult; aged; Article; breast cancer; cancer chemotherapy; cancer patient; cancer prognosis; cohort analysis; disease assessment; distant metastasis; distant metastasis free survival; female; follow up; geneswell breast cancer test; hormonal therapy; human; human epidermal growth factor receptor 2 negative breast cancer; immunohistochemistry; in situ hybridization; lymph node dissection; major clinical study; middle aged; overall survival; predictive value; propensity score; prospective study; protein expression; recurrence free survival; risk assessment; triple negative breast cancer; tumor invasion; tumor volume; validation study | English | 2021 | 2021-02-23 | 10.3389/fonc.2021.588728 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | A Well-Structured Follow-Up Program is Required after Recovery from Coronavirus Disease 2019 (COVID-19); Release from Quarantine is Not the End of Treatment | During the Coronavirus Infection Disease-19 (COVID-19) pandemic, the number of patients released from quarantine is exceeding the number of newly diagnosed cases. This study is a retrospective cohort study in which consultation data were collected from a COVID-19 follow-up health consultation program. The studied population was selected from patients who recovered after quarantine and treatment for COVID-19 in Daegu City and in Gyeongsangbukdo province, Korea, from March to June 2020. The healthcare providers comprised 20 family-medicine specialists who consulted and educated the patients through phone calls in accordance with structured guidelines. Physical and mental status before and after recovery were compared among patients who received a single consultation and those who received two or more consultations. A total of 1604 subjects were selected for the final analysis. Of these, 1145 (71.4%) had one consultation and 459 (28.6%) had two or more. The group that had two or more consultations reported significantly more physical symptoms, more psychological symptoms (including depression), and more psychological stress. Multivariate forward selection logistic regression analysis showed that re-confirmed cases of COVID-19, physical symptoms after quarantine, feelings of depression, and psychological stress had a significant effect on the number of consultations received. In conclusion, COVID-19 has various physical and mental sequelae after discharge from quarantine. Therefore, a well-structured follow-up program is needed after recovery. | Lee, Keun-Mi; Ko, Hae-Jin; Lee, Geon Ho; Kim, A-Sol; Lee, Dong-Wook | Yeungnam Univ, Med Ctr, Sch Med, Dept Family Med, Daegu 42415, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Family Med, Daegu 41944, South Korea; Daegu Catholic Univ, Dept Family Med, Sch Med, Daegu 42472, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Family Med, Deagu 41404, South Korea; Dongguk Univ, Dept Family Med, Gyeongju Hosp, Gyeongju 38067, South Korea | ; Lee, Geon Ho/HLG-1707-2023 | 56101036000; 54393415700; 36104322100; 57203290656; 57263010900 | kmlee@yu.ac.kr;liveforme@knu.ac.kr;totoslee@cu.ac.kr;deepai@knu.ac.kr;fmleedu@dongguk.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 10 | 11 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 4.964 | 31.7 | 0.34 | 2025-07-30 | 2 | 3 | COVID-19; consultation; comprehensive health care; mental health; pandemics | ASSOCIATION; LIFE | Comprehensive health care; Consultation; COVID‐19; Mental health; Pandemics | abdominal discomfort; adult; Article; chest tightness; cohort analysis; consultation; controlled study; coronavirus disease 2019; coughing; depression; dysgeusia; dysosmia; dyspnea; female; fever; follow up; headache; health care; health care personnel; health education; human; hypertension; major clinical study; malaise; male; mental health; mental stress; middle aged; myalgia; neurologic disease; nose obstruction; practice guideline; program evaluation; quarantine; retrospective study; rhinorrhea; sore throat; thorax pain | English | 2021 | 2021-06 | 10.3390/jcm10112329 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Analysis of Factors Associated with the Postoperative Healing of Medication-Related Osteonecrosis of the Jaw in Patients with Osteoporosis | Background: Surgical treatment is considered the best approach by many researchers for medication-related osteonecrosis of the jaws (MRONJ). While postoperative outcomes are mainly favorable, wound healing still fails in some cases. This retrospective study aimed to evaluate the factors affecting the postoperative healing of MRONJ. Methods: This study involved 400 osteoporosis patients who received surgical treatment from January 2009 to January 2018 in Kyungpook National University Hospital. The patient, drug, and clinical factors were collected as investigation variables. The obtained data were statistically analyzed to identify relationships between the factors and healing aspect. Results: Univariate logistic regression analysis showed that the route of drug administration, bone exposure, types of surgical management, and wound management had a significant influence (p 0.05). Conclusion: In patients with osteoporosis, the factors such as intravenously administered drugs, fistulas that were probed to the bone, and surgical management with curettage were associated with a lower rate of postoperative complete healing of MRONJ, whereas primary closure of wounds led, possibly, to good healing outcomes. The strengths of the study include its relatively large sample size and that its results can hopefully aid in the clinical decisions for practitioners and future research studies for researchers. | Shim, Young-Ho; Jung, Sang-Hwan; Boboeva, Obida; Lee, Sung-Tak; Kim, Jin-Wook; Kwon, Tae-Geon; Choi, So-Young | Kyungpook Natl Univ, Sch Dent, Dept Oral & Maxillofacial Surg, 2177 Dalgubeol Daero, Daegu 41940, South Korea | 57226812147; 57226815042; 57220642750; 55931708300; 55862646000; 35205433300; 57202918688 | asimjjang@naver.com;hello909@naver.com;boboyevaobida@gmail.com;st0907@knu.ac.kr;vocaleo@knu.ac.kr;kwondk@knu.ac.kr;dentalchoi@knu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 10 | 16 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 4.964 | 31.7 | 0.34 | 2025-07-30 | 5 | 5 | MRONJ; surgical treatment; postoperative healing; sequestrectomy; primary closure | BISPHOSPHONATE-RELATED OSTEONECROSIS; SURGICAL-MANAGEMENT; TREATMENT OUTCOMES; STAGE; FLUORESCENCE; PERSPECTIVES; STRATEGIES; RECURRENCE; THERAPY; MRONJ | MRONJ; Postoperative healing; Primary closure; Sequestrectomy; Surgical treatment | alendronic acid; ibandronic acid; pamidronic acid; risedronic acid; zoledronic acid; adult; aged; Article; curettage; female; human; major clinical study; male; medication related osteonecrosis of the jaw; osteoporosis; prevalence; retrospective study; university hospital; wound healing | English | 2021 | 2021-08 | 10.3390/jcm10163651 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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