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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Changes in the secondary compounds of persimmon leaves as a defense against circular leaf spot caused by Plurivorosphaerella nawae | Circular leaf spot, caused by the ascomycetous fungus Plurivorosphaerella nawae (= Mycosphaerella nawae), is the most problematic fungal disease of persimmon worldwide. In Korea, persimmon exposed to P. nawae inoculum (ascospores) from May to August shows visible circular leaf spot disease symptoms from the end of August to early September. It is important to identify factors affecting this long latent period. The objective of this study was to elucidate the relation between the development of symptom of circular leaf spot and the content of phenolics compounds and vitamin C as well as the antioxidant activities in leaves. Healthy leaves (both young and old) and infected leaves of circular leaf spot-susceptible persimmon cultivar were harvested in 2016. The content of phenolics (total phenols, flavonoids, and tannins) and vitamin C, and their antioxidant activities were analyzed in all types of leaves. Compared with the asymptomatic leaves (old) and the asymptomatic parts of the infected leaves, the symptomatic parts of the infected leaves, symptomatic leaves, and asymptomatic young leaves showed significantly higher content of phenolics and vitamin C, and higher antioxidant activities. Disease incidence and severity were estimated for older leaves (emerged in early May) and younger leaves (emerged at the end of June) in 2017 and 2018. The AUDPC was higher in old leaves than younger leaves. The disease progression was much faster and severe in the older than in the younger leaves. Similar results were found in field experiments. Higher content of phenolics and antioxidant activities in the younger leaves may contribute to circular leaf spot resistance in persimmon. Furthermore, accumulation of phenolics and antioxidant activity in the infected leaves is a post-infection response and the first stage of the defense mechanism. | Hassan, Oliul; Chang, Taehyun; Hossain, Abul | Kyungpook Natl Univ, Coll Ecol & Environm Sci, Dept Ecol & Environm Syst, Sangju Si, Gyeongsangbuk D, South Korea; Mem Univ Newfoundland, Dept Biochem, St John, NF, Canada | Chang, Taehyun/S-1364-2019; Hossain, Abul/AAE-4714-2020; Hassan, Oliul/AEB-6678-2022 | 12762464400; 55301101700; 57197763675 | thchang@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 3 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.27 | 2025-06-25 | 7 | 9 | PHENOLIC-COMPOUNDS; MYCOSPHAERELLA-NAWAE; ANTIOXIDANT ACTIVITY; TANNINS; RESISTANCE; FLAVAN-3-OLS; INFECTION; DYNAMICS; INOCULUM; PLANTS | Ascomycota; Ascorbic Acid; Diospyros; Flavonoids; Plant Immunity; Plant Leaves; Tannins; ascorbic acid; flavonoid; phenol derivative; tannin; ascorbic acid; tannin derivative; antioxidant activity; Article; Ascomycetes; bioaccumulation; chemical composition; circular leaf spot; controlled study; disease exacerbation; disease severity; incidence; leaf age; leaf spot; nonhuman; persimmon; phytochemistry; plant defense; plant leaf; Plurivorosphaerella nawae; Ascomycetes; Diospyros; immunology; metabolism; microbiology; pathogenicity; plant immunity | English | 2020 | 2020-03-06 | 10.1371/journal.pone.0230286 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Characterizing the role of Zn cluster family transcription factor ZcfA in governing development in two Aspergillus species | Filamentous fungi reproduce asexually or sexually, and the processes of asexual and sexual development are tightly regulated by a variety of transcription factors. In this study, we characterized a Zn(2)Cys(6) transcription factor in two Aspergillus species, A. nidulans (AN5859) and A. flavus (AFLA₀₄₆₈₇₀). AN5859 encodes a Zn(2)Cys(6) transcription factor, called ZcfA. In A. nidulans,.zcfA mutants exhibit decreased fungal growth, a reduction in cleistothecia production, and increased asexual reproduction. Overexpression of zcfA results in increased conidial production, suggesting that ZcfA is required for proper asexual and sexual development in A. nidulans. In conidia, deletion of zcfA causes decreased trehalose levels and decreased spore viability but increased thermal sensitivity. In A. flavus, the deletion of the zcfA homolog AFLA₀₄₆₈₇₀ causes increased conidial production but decreased sclerotia production; these effects are similar to those of zcfA deletion in A. nidulans development. Overall, these results demonstrate that ZcfA is essential for maintaining a balance between asexual and sexual development and that some roles of ZcfA are conserved in Aspergillus spp. | Son, Ye-Eun; Cho, He-Jin; Lee, Mi-Kyung; Park, Hee-Soo | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Biol Resource Ctr BRC, Jeongeup Si, South Korea; Kyungpook Natl Univ, Dept Integrat Biol, Daegu, South Korea | ; Park, Hee-Soo/AAC-6422-2019 | 57200513491; 57214721558; 57221217721; 15751448400 | phsoo97@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 2 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.72 | 2025-06-25 | 20 | 19 | SEXUAL DEVELOPMENT; GENE ENCODES; NIDULANS; ACTIVATOR; BRLA; IDENTIFICATION; FUMIGATUS; INSIGHTS; BINDING; FLAVUS | Aspergillus flavus; Aspergillus nidulans; Fungal Proteins; Metalloproteins; Reproduction; Reproduction, Asexual; Species Specificity; Transcription Factors; Zinc; sterigmatocystin; zinc; fungal protein; metalloprotein; transcription factor; zinc; AN5859 gene; Article; asexual reproduction; Aspergillus flavus; Aspergillus nidulans; controlled study; fungal gene; fungal strain; fungus culture; fungus growth; gene deletion; gene expression; nonhuman; promoter region; real time polymerase chain reaction; sexual development; temperature stress; thin layer chromatography; ZcfA gene; Aspergillus flavus; Aspergillus nidulans; growth, development and aging; physiology; reproduction; species difference | English | 2020 | 2020-02-04 | 10.1371/journal.pone.0228643 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Cytoglobin deficiency potentiates Crb1-mediated retinal degeneration in rd8 mice | Purpose: The purpose of this study is to determine the effect of Cytoglobin (Cygb) deficiency on Crb1-related retinopathy. The Crb1 cell polarity complex is required for photoreceptor function and survival. Crb1-related retinopathies encompass a broad range of phenotypes which are not completely explained by the variability of Crb1 mutations. Genes thought to modify Crb1 function are therefore important targets of research. The biological function of Cygb involves oxygen delivery, scavenging of reactive oxygen species, and nitric oxide metabolism. However, the relationship of Cygb to diseases involving the Crb1 cell polarity complex is unknown. Methods: Cygb knockout mice homozygous for the rd8 mutation (Cygb(-/-rd8/rd8)) were screened for ocular abnormalities and imaged using optical coherence tomography and fundus photography. Electroretinography was performed, as was histology and immunohistochemistry. Quantitative PCR was used to determine the effect of Cygb deficiency on transcription of Crb1 related cell polarity genes. Results: Cygb(-/-rd8/rd8) mice develop an abnormal retina with severe lamination abnormalities. The retina undergoes progressive degeneration with the ventral retina more severely affected than the dorsal retina. Cygb expression is in neurons of the retinal ganglion cell layer and inner nuclear layer. Inununohistochemical studies suggest that cell death predominates in the photoreceptors. Electroretinography amplitudes show reduced a- and b-waves, consistent with photoreceptor disease. Cygb deficient retinas had only modest transcriptional perturbations of Crb1-related cell polarity genes. Cygb(-/-) mice without the rd8 mutation did not exhibit obvious retinal abnormalities. Conclusions: Cygb is necessary for retinal lamination, maintenance of cell polarity, and photoreceptor survival in rd8 mice. These results are consistent with Cygb as a disease modifying gene in Crb1-related retinopathy. Further studies are necessary to investigate the role of Cygb in the human retina. | Kwon, Young Sam; Tham, Addy; Lopez, Antonio Jacobo; Edwards, Sydney; Woods, Sean; Chen, Jiajia; Wong-Fortunato, Jenna; Alonso, Alejandra Quiroz; Javier, Seanne; Au, Ingrid; Clarke, Maria; Humpal, Devin; Lloyd, K. C. Kent; Thomasy, Sara; Murphy, Christopher; Glaser, Thomas M.; Moshiri, Ala | Univ Calif Davis, Dept Ophthalmol & Vis Sci, Sch Med, Sacramento, CA 95817 USA; Kyungpook Natl Univ, Coll Vet Med, Daegu, South Korea; Univ Calif Davis, Dept Surg & Radiol Sci, Sch Vet Med, Davis, CA 95817 USA; Univ Calif Davis, Mouse Biol Program, Davis, CA USA; Univ Calif Davis, Dept Surg, Sch Med, Sacramento, CA 95817 USA; Univ Calif Davis, Dept Cell Biol & Human Anat, Sch Med, Davis, CA USA | 7403459426; 57193720313; 57211920444; 57201639608; 56604662400; 57211923152; 57211928094; 57211917154; 57211915264; 57211915160; 58909781800; 57193719148; 35230265300; 8680496300; 7401763972; 7004968880; 15748644100 | amoshiri@ucdavis.edu; | DEVELOPMENTAL BIOLOGY | DEV BIOL | 0012-1606 | 1095-564X | 458 | 2 | SCIE | DEVELOPMENTAL BIOLOGY | 2020 | 3.582 | 35.4 | 0.22 | 2025-06-25 | 8 | 9 | LEBER CONGENITAL AMAUROSIS; OXIDE DIOXYGENASE FUNCTION; RETINITIS-PIGMENTOSA; CRUMBS HOMOLOG-1; NITRIC-OXIDE; OXYGEN-BINDING; CRB1; PROTEIN; NEUROGLOBIN; MUTATIONS | Animals; Cytoglobin; Disease Models, Animal; Eye Proteins; Female; Homozygote; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Nerve Tissue Proteins; Phenotype; Retina; Retinal Degeneration; Retinal Ganglion Cells; cytoglobin; eye protein; protein; protein Crumbs; retinal degeneration 8; unclassified drug; Crb1 protein, mouse; Cygb protein, mouse; cytoglobin; membrane protein; nerve protein; A wave; adult; animal cell; animal experiment; animal model; animal tissue; Article; B wave; cell death; cell polarity; cell survival; controlled study; Crb1 gene; disease severity; electroretinography; eye malformation; eye photography; female; gene mutation; genetic screening; genetic transcription; histology; homozygosity; immunohistochemistry; male; mouse; nonhuman; optical coherence tomography; photoreceptor; polymerase chain reaction; priority journal; protein deficiency; protein expression; rd8 gene; retina degeneration; retinal ganglion cell layer; retinal inner nuclear layer; animal; C57BL mouse; disease model; genetics; homozygote; knockout mouse; metabolism; mutation; pathophysiology; phenotype; retina; retina degeneration; retina ganglion cell | English | 2020 | 2020-02-15 | 10.1016/j.ydbio.2019.10.013 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Deep-learning algorithms for the interpretation of chest radiographs to aid in the triage of COVID-19 patients: A multicenter retrospective study | The recent medical applications of deep-learning (DL) algorithms have demonstrated their clinical efficacy in improving speed and accuracy of image interpretation. If the DL algorithm achieves a performance equivalent to that achieved by physicians in chest radiography (CR) diagnoses with Coronavirus disease 2019 (COVID-19) pneumonia, the automatic interpretation of the CR with DL algorithms can significantly reduce the burden on clinicians and radiologists in sudden surges of suspected COVID-19 patients. The aim of this study was to evaluate the efficacy of the DL algorithm for detecting COVID-19 pneumonia on CR compared with formal radiology reports. This is a retrospective study of adult patients that were diagnosed as positive COVID-19 cases based on the reverse transcription polymerase chain reaction among all the patients who were admitted to five emergency departments and one community treatment center in Korea from February 18, 2020 to May 1, 2020. The CR images were evaluated with a publicly available DL algorithm. For reference, CR images without chest computed tomography (CT) scans classified as positive for COVID-19 pneumonia were used given that the radiologist identified ground-glass opacity, consolidation, or other infiltration in retrospectively reviewed CR images. Patients with evidence of pneumonia on chest CT scans were also classified as COVID-19 pneumonia positive outcomes. The overall sensitivity and specificity of the DL algorithm for detecting COVID-19 pneumonia on CR were 95.6%, and 88.7%, respectively. The area under the curve value of the DL algorithm for the detection of COVID-19 with pneumonia was 0.921. The DL algorithm demonstrated a satisfactory diagnostic performance comparable with that of formal radiology reports in the CR-based diagnosis of pneumonia in COVID-19 patients. The DL algorithm may offer fast and reliable examinations that can facilitate patient screening and isolation decisions, which can reduce the medical staff workload during COVID-19 pandemic situations. | Jang, Se Bum; Lee, Suk Hee; Lee, Dong Eun; Park, Sin-Youl; Kim, Jong Kun; Cho, Jae Wan; Cho, Jaekyung; Kim, Ki Beom; Park, Byunggeon; Park, Jongmin; Lim, Jae-Kwang | Yeungnam Univ, Dept Emergency Med, Coll Med, Daegu, South Korea; Daegu Catholic Univ, Dept Emergency Med, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Emergency Med, Daegu, South Korea; Daegu Fatima Hosp, Dept Emergency Med, Daegu, South Korea; Daegu Fatima Hosp, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea | ; Kim, Joo/JAZ-0897-2023; Lee, Dong Eun/HTN-4501-2023 | 57220081900; 57205602138; 57202299238; 56184913500; 55915816900; 7403536065; 57220081552; 59080545400; 57211532915; 57216463879; 55515341400 | delee@knu.ac.kr;dryuri@naver.com; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 11 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.77 | 2025-06-25 | 14 | 19 | Adult; Aged; Aged, 80 and over; COVID-19; Data Accuracy; Deep Learning; Female; Humans; Male; Middle Aged; Radiographic Image Interpretation, Computer-Assisted; Radiography, Thoracic; Radiologists; Reproducibility of Results; Republic of Korea; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; SARS-CoV-2; Sensitivity and Specificity; Tomography, X-Ray Computed; Triage; adult; algorithm; Article; clinical effectiveness; coronavirus disease 2019; deep learning; evidence based medicine; false negative result; false positive result; female; ground glass opacity; hospital admission; human; image analysis; image processing; major clinical study; male; medical decision making; medical staff; multicenter study; patient isolation; predictive value; retrospective study; reverse transcription polymerase chain reaction; screening test; sensitivity and specificity; thorax radiography; virus pneumonia; workload; aged; clinical trial; computer assisted diagnosis; diagnostic imaging; emergency health service; epidemiology; genetics; measurement accuracy; middle aged; procedures; radiologist; reproducibility; South Korea; thorax radiography; very elderly; virology; x-ray computed tomography | English | 2020 | 2020-11-24 | 10.1371/journal.pone.0242759 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Determining the cut-off score for the Modified Barthel Index and the Modified Rankin Scale for assessment of functional independence and residual disability after stroke | Assessment of functional independence and residual disability is very important for measuring treatment outcome after stroke. The modified Rankin Scale (mRS) and the modified Barthel Index (MBI) are commonly used scales to measure disability or dependence in activities of daily living (ADL) of stroke survivors. Lack of consensus regarding MBI score categories has caused confusion in interpreting stroke outcomes. The purpose of this study was to identify the optimal corresponding MBI and modified Rankin scale (mRS) grades for categorization of MBI. The Korean versions of the MBI (K-MBI) and mRS were collected from 5,759 stroke patients at 3 months after onset of stroke. The sensitivity and specificity were calculated at K-MBI score cutoffs for each mRS grade to obtain optimally corresponding K-MBI scores and mRS grades. We also plotted receiver operating characteristic (ROC) curves of sensitivity and specificity and determined the area under the curve (AUC). The K-MBI cutoff points with the highest sum of sensitivity and specificity were 100 (sensitivity 0.940; specificity 0.612), 98 (sensitivity 0.904; specificity 0.838), 94 (sensitivity 0.885; specificity 0.937), 78 (sensitivity 0.946; specificity, 0.973), and 55 (sensitivity 937; specificity 0.986) for mRS grades 0, 1, 2, 3, and 4, respectively. From this result, the K-MBI cutoff score range for each mRS grade can be obtained. For mRS grade 0, the K-MBI cutoff score is 100, indicating no associated score range. For mRS grades 1, 2, 3, 4, and 5, the K-MBI score ranges is from 99 to 98, 97 to 94, 93 to 78, 77 to 55, and under 54, respectively.The AUC for the ROC curve was 0.791 for mRS grade 0, 0.919 for mRS grade 1, 0.970 for mRS grade 2, 0.0 for mRS grade 3, and 0.991 for mRS grade 4. The K-MBI cutoff score ranges for representing mRS grades were variable; mRS grades 0, 1, and 2 had narrow K-MBI score ranges, while mRS grades 3, 4, and 5 exhibited broad K-MBI score ranges. mRS grade seemed to sensitively differentiate mild residual disability of stroke survivors, whereas K-MBI provided more specific information of the functional status of stroke survivors with moderate to severe residual impairment. | Lee, Seung Yeol; Kim, Deog Young; Sohn, Min Kyun; Lee, Jongmin; Lee, Sam-Gyu; Shin, Yong-Il; Kim, Soo-Yeon; Oh, Gyung-Jae; Lee, Young Hoon; Lee, Yang-Soo; Joo, Min Cheol; Lee, So Young; Ahn, Jeonghoon; Chang, Won Hyuk; Choi, Ji Yoo; Kang, Sung Hyun; Kim, Il Yoel; Han, Junhee; Kim, Yun-Hee | Sungkyunkwan Univ, Samsung Med Ctr, Heart Vasc & Stroke Inst, Dept Phys & Rehabil Med,Ctr Prevent & Rehabil,Sch, Seoul, South Korea; Yonsei Univ, Dept & Res Inst Rehabil Med, Coll Med, Seoul, South Korea; Chungnam Natl Univ, Sch Med, Dept Rehabil Med, Daejeon, South Korea; Konkuk Univ, Dept Rehabil Med, Sch Med, Seoul, South Korea; Chonnam Natl Univ, Dept Phys & Rehabil Med, Med Sch, Gwangju, South Korea; Pusan Natl Univ, Dept Rehabil Med, Yangsan Hosp, Yangsan, South Korea; Wonkwang Univ, Dept Prevent Med, Sch Med, Iksan, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Rehabil Med, Daegu, South Korea; Wonkwang Univ, Dept Rehabil Med, Sch Med, Iksan, South Korea; Univ Jeju, Jeju Natl Univ Hosp, Dept Rehabil Med, Coll Med, Jeju, South Korea; Ewha Womans Univ, Dept Hlth Convergence, Seoul, South Korea; Korea Ctr Dis Control & Prevent, Div Chron Dis Prevent, Osong, South Korea; Hallym Univ, Dept Stat, Chunchon, South Korea; Hallym Univ, Inst Stat, Chunchon, South Korea; Sungkyunkwan Univ, Dept Digital Hlth, SAIHST, Dept Hlth Sci & Technol,Dept Med Device Managemen, Seoul, South Korea | Ahn, Jeonghoon/CAA-1956-2022; Lee, Jongmin/Q-4909-2019; Kim, Yun-Hee/GVS-6426-2022; kim, deog young/Q-8498-2019 | 57211724946; 55375583000; 7101840459; 57202882113; 10142402000; 55890990500; 57203773165; 7007056685; 55716155400; 57202952463; 56982599700; 57202327370; 8855402200; 35301717900; 57212612679; 57212614899; 57214361107; 57192890252; 57020121600 | hanjh@hallym.ac.kr;Yyun1225.kim@samsung.com; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 2.31 | 2025-06-25 | 65 | 67 | REHABILITATION; RELIABILITY; SENSITIVITY; HANDICAP; VALIDITY; VERSION; GRADES; TOOL | Activities of Daily Living; Aged; Disability Evaluation; Disabled Persons; Disease Progression; Female; Humans; Logistic Models; Male; Middle Aged; Outcome Assessment, Health Care; ROC Curve; Severity of Illness Index; Stroke; Stroke Rehabilitation; Treatment Outcome; adult; Article; Barthel index; cerebrovascular accident; clinical evaluation; clinical feature; cohort analysis; controlled study; daily life activity; diagnostic test accuracy study; disability; disease exacerbation; disease severity; female; Functional Independence Measure; functional status; human; major clinical study; male; medical information; middle aged; Rankin scale; receiver operating characteristic; residual disability; sensitivity and specificity; aged; cerebrovascular accident; disabled person; pathophysiology; procedures; rehabilitation; severity of illness index; statistical model; stroke rehabilitation; treatment outcome | English | 2020 | 2020-01-29 | 10.1371/journal.pone.0226324 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Dietary antioxidants impact DDT resistance in Drosophila melanogaster | Insects experience a diversity of subtoxic and/or toxic xenobiotics through exposure to pesticides and, in the case of herbivorous insects, through plant defensive compounds in their diets. Many insects are also concurrently exposed to antioxidants in their diets. The impact of dietary antioxidants on the toxicity of xenobiotics in insects is not well understood, in part due to the challenge of developing appropriate systems in which doses and exposure times (of both the antioxidants and the xenobiotics) can be controlled and outcomes can be easily measured. However, inDrosophila melanogaster, a well-established insect model system, both dietary factors and pesticide exposure can be easily controlled. Additionally, the mode of action and xenobiotic metabolism of dichlorodiphenyltrichloroethane (DDT), a highly persistent neurotoxic organochlorine insecticide that is detected widely in the environment, have been well studied in DDT-susceptible and -resistant strains. Using a glass-vial bioassay system with blue diet as the food source, seven compounds with known antioxidant effects (ascorbic acid, beta-carotene, glutathione, alpha-lipoic acid, melatonin, minocycline, and serotonin) were orally tested for their impact on DDT toxicity across three strains ofD.melanogaster: one highly susceptible to DDT (Canton-S), one mildly susceptible (91-C), and one highly resistant (91-R). Three of the antioxidants (serotonin, ascorbic acid, and beta-carotene) significantly impacted the toxicity of DDT in one or more strains. Fly strain and gender, antioxidant type, and antioxidant dose all affected the relative toxicity of DDT. Our work demonstrates that dietary antioxidants can potentially alter the toxicity of a xenobiotic in an insect population. | Abdu-Allah, Gamal A. M.; Seong, Keon Mook; Mittapalli, Omprakash; Ojos, James Adebayo; Sun, Weilin; Posos-Parra, Omar; Mota-Sanchez, David; Clarks, John M.; Pittendrigh, Barry R. | Michigan State Univ, Dept Entomol, E Lansing, MI 48824 USA; Assiut Univ, Dept Plant Protect, Assiut, Egypt; Kyungpook Natl Univ, Dept Appl Biol, Sangju, Gyeongbuk, South Korea; Univ Kentucky, Dept Entomol, Lexington, KY USA; Kwara State Univ, Dept Crop Prod, Ilorin, Nigeria; Univ Massachusetts, Dept Vet & Anim Sci, Amherst, MA 01003 USA | Sun, Wei Lin/JMB-5547-2023; Ojo, James Adebayo/F-5879-2017; Mota-Sanchez, David/ABD-6869-2020 | 54392551600; 26635871000; 8593251100; 55351728900; 55726591200; 57218656395; 12144113300; 7407829142; 7004045385 | pittendr@msu.edu; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 8 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.23 | 2025-06-25 | 6 | 7 | INDUCED OXIDATIVE STRESS; BETA-CAROTENE; LIFE-SPAN; BIOCHEMICAL PARAMETERS; 91-R STRAIN; SEROTONIN; TOXICITY; SUPPLEMENTATION; SYSTEMS; INSECT | Animals; Antioxidants; DDT; Diet; Dose-Response Relationship, Drug; Drosophila melanogaster; Female; Genotype; Insecticide Resistance; Male; Serotonin; Sex Characteristics; ascorbic acid; beta carotene; chlorphenotane; glutathione; melatonin; minocycline; serotonin; thioctic acid; xenobiotic agent; antioxidant; chlorphenotane; serotonin; adult; animal experiment; antioxidant activity; arthropod community; Article; bioassay; chemical analysis; concentration (parameter); controlled study; dietary intake; Drosophila melanogaster; Drosophila melanogaster 91 C; Drosophila melanogaster 91 R; Drosophila melanogaster Canton S; drug efficacy; environmental exposure; female; gender; genotype; male; neurotoxicity; nonhuman; pesticide resistance; xenobiotic metabolism; animal; diet; dose response; Drosophila melanogaster; drug effect; genetics; insecticide resistance; physiology; sexual characteristics | English | 2020 | 2020-08-25 | 10.1371/journal.pone.0237986 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Effect of citywide enhancement of the chain of survival on good neurologic outcomes after out-of-hospital cardiac arrest from 2008 to 2017 | Improving outcomes after out-of-hospital cardiac arrests (OHCAs) requires an integrated approach by strengthening the chain of survival and emergency care systems. This study aimed to identify the change in outcomes over a decade and effect of citywide intervention on good neurologic outcomes after OHCAs in Daegu. This is a before- and after-intervention study to examine the association between the citywide intervention to improve the chain of survival and outcomes after OHCA. The primary outcome was a good neurologic outcome, defined as a cerebral performance category score of 1 or 2. After dividing into 3 phases according to the citywide intervention, the trends in outcomes after OHCA by primary electrocardiogram rhythm were assessed. Logistic regression analysis was used to analyze the association between the phases and outcomes. Overall, 6203 patients with OHCA were eligible. For 10 years (2008-2017), the rate of survival to discharge and the good neurologic outcomes increased from 2.6% to 8.7% and from 1.5% to 6.6%, respectively. Especially for patients with an initial shockable rhythm, these changes in outcomes were more pronounced (survival to discharge: 23.3% in 2008 to 55.0% in 2017, good neurologic outcomes: 13.3% to 46.0%). Compared with phase 1, the adjusted odds ratio (AOR) and 95% confidence intervals (CI) for good neurologic outcomes was 1.20 (95% CI: 0.78-1.85) for phase 2 and 1.64 (1.09-2.46) for phase 3. For patients with an initial shockable rhythm, the AOR for good neurologic outcomes was 3.76 (1.88-7.52) for phase 2 and 5.51 (2.77-10.98) for phase 3. Citywide improvement was observed in the good neurologic outcomes after OHCAs of medical origin, and the citywide intervention was significantly associated with better outcomes, particularly in those with initial shockable rhythm. | Lee, Dong Eun; Ryoo, Hyun Wook; Moon, Sungbae; Park, Jeong Ho; Shin, Sang Do | Kyungpook Natl Univ, Dept Emergency Med, Chilgok Hosp, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Emergency Med, Kyungpook Natl Univ Hosp, Sch Med, Daegu, South Korea; Seoul Natl Univ, Dept Emergency Med, Coll Med, Seoul, South Korea | Lee, Dong Eun/HTN-4501-2023; Do Shin, Sang/D-6020-2012 | 57202299238; 55350557500; 57191584601; 57222635486; 57049712400 | ryoo@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 11 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.23 | 2025-06-25 | 8 | 7 | HEART-ASSOCIATION GUIDELINES; ADVANCED AIRWAY MANAGEMENT; CARDIOPULMONARY-RESUSCITATION; CARE; UPDATE; TRENDS; RATES | Advanced Cardiac Life Support; Aged; Cardiopulmonary Resuscitation; Emergency Treatment; Female; Humans; Logistic Models; Male; Middle Aged; Out-of-Hospital Cardiac Arrest; Recovery of Function; Survival Analysis; Treatment Outcome; aged; Article; cerebral performance category score; child; disease association; electrocardiography; emergency care; female; heart rhythm; hospital discharge; human; incidence; Korea; major clinical study; male; mental performance; neurological complication; out of hospital cardiac arrest; outcome assessment; survival rate; total quality management; trend study; convalescence; emergency treatment; middle aged; mortality; out of hospital cardiac arrest; pathophysiology; procedures; resuscitation; statistical model; survival analysis; treatment outcome | English | 2020 | 2020-11-06 | 10.1371/journal.pone.0241804 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Evaluation of the pharmacokinetic-pharmacodynamic integration of marbofloxacin in combination with methyl gallate against Salmonella Typhimurium in rats | Fluoroquinolone resistance inSalmonellaTyphimurium is becoming a major concern. Hence, an intervention to limit the growth in resistance is inevitable. One way to combat this challenge is through combination therapy. The combination of antibiotics with phytochemicals has become an ideal means of preventing antimicrobial resistance. Recently, in anin vitrostudy, the combination of methyl gallate (MG) with marbofloxacin (MAR) has shown to preventSalmonellaTyphimurium invasion. It is also worth to study the effects of plant extracts on the pharmacokinetics of antibiotics. Hence, the objective of this study was to determine the effect of MG on the pharmacokinetics of MAR and pharmacokinetics/pharmacodynamics integration of MG and MAR. The micro-broth dilution method was used to obtain the minimum inhibitory concentration (MIC), and fractional inhibitory concentration (FIC) of MAR and MG. Whereas, the pharmacokinetic was conducted in rats by administering either MAR alone or combined with MG through oral and/or intravenous routes. The results indicated that the MIC of MAR and MG against standard strainSalmonellaTyphimurium (ATCC 14028) was 0.031 and 500 mu g/mL, respectively. The FIC(index)of the combination of MAR and MG was 0.5. For orally administered drugs, the C(max)and AUC(24h)of MAR were 1.04 and 0.78 mu g/mL and 5.98 and 6.11 h.mu g/mL when MAR was given alone and in combination with MG, respectively. The intravenous administration of MAR showed a half-life of 3.8 and 3.9 h; a clearance rate of 1.1 and 0.73 L/h/kg and a volume of distribution of 5.98 and 4.13 L/kg for MAR alone and in combination with MG, respectively. The AUC(24)/MIC for MAR alone and in combination with MG was 192.8 and 381.9 h, respectively. In conclusion, MG has shown to increase the antimicrobial activity of MARin vitroandex vivoexperiments without affecting the pharmacokinetics of MAR in rats. | Birhanu, Biruk Tesfaye; Lee, Eon-Bee; Park, Seung-Chun | Kyungpook Natl Univ, Coll Vet Med, Lab Vet Pharmacokinet & Pharmacodynam, Daegu, South Korea | Lee, Jung Bok/HHZ-3200-2022; Birhanu, Biruk/F-1622-2017; Park, Seung-Chun/AAV-3388-2021 | 56996190000; 57216526135; 7501832396 | parksch@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 6 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.42 | 2025-06-25 | 9 | 9 | MUTANT-PREVENTION CONCENTRATION; FLUOROQUINOLONE RESISTANCE; ESCHERICHIA-COLI; CIPROFLOXACIN; EXPOSURE; ANIMALS; RHOIS; ACID | Animals; Drug Interactions; Fluoroquinolones; Gallic Acid; Male; Microbial Sensitivity Tests; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; gallic acid methyl ester; marbofloxacin; gallic acid; gallic acid methyl ester; marbofloxacin; quinolone derivative; animal experiment; animal model; antimicrobial activity; area under the curve; Article; bacterial clearance; bactericidal activity; bacteriostatic activity; concentration response; controlled study; dilution; drug clearance; drug effect; drug half life; ex vivo study; fractional inhibitory concentration; high performance liquid chromatography; in vitro study; male; maximum concentration; micro broth dilution method; minimum inhibitory concentration; nonhuman; pharmacodynamics; pharmacokinetics; rat; Salmonella enterica serovar Typhimurium; Sprague Dawley rat; volume of distribution; animal; drug interaction; microbial sensitivity test; Salmonella enterica serovar Typhimurium | English | 2020 | 2020-06-04 | 10.1371/journal.pone.0234211 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Extending thermotolerance to tomato seedlings by inoculation with SA1 isolate of Bacillus cereus and comparison with exogenous humic acid application | Heat stress is one of the major abiotic stresses that impair plant growth and crop productivity. Plant growth-promoting endophytic bacteria (PGPEB) and humic acid (HA) are used as bio-stimulants and ecofriendly approaches to improve agriculture crop production and counteract the negative effects of heat stress. Current study aimed to analyze the effect of thermotolerant SA1 an isolate of Bacillus cereus and HA on tomato seedlings. The results showed that combine application of SA1+HA significantly improved the biomass and chlorophyll fluorescence of tomato plants under normal and heat stress conditions. Heat stress increased abscisic acid (ABA) and reduced salicylic acid (SA) content; however, combined application of SA1+HA markedly reduced ABA and increased SA. Antioxidant enzymes activities revealed that SA1 and HA treated plants exhibited increased levels of ascorbate peroxidase (APX), superoxide dismutase (SOD), and reduced glutathione (GSH). In addition, heat stress markedly reduced the amino acid contents; however, the amino acids were increased with co-application of SA1 +HA. Similarly, inductively-coupled plasma mass-spectrometry results showed that plants treated with SA1+HA exhibited significantly higher iron (Fe+), phosphorus (P), and potassium (K+) uptake during heat stress. Heat stress increased the relative expression of SlWRKY33b and autophagy-related (SlATG5) genes, whereas co-application of SA1+HA augmented the heat stress response and reduced SlWRKY33b and SlATG5 expression. The heat stress-responsive transcription factor (SlHsfA1a) and high-affinity potassium transporter (SlHKT1) were upregulated in SA1+HA-treated plants. In conclusion, current findings suggest that co-application with SA1+HA can be used for the mitigation of heat stress damage in tomato plants and can be commercialized as a biofertilizer. | Khan, Muhammad Aaqil; Asaf, Sajjad; Khan, Abdul Latif; Jan, Rahmatullah; Kang, Sang-Mo; Kim, Kyung-Min; Lee, In-Jung | Kyungpook Natl Univ, Sch Appl Biosci, Daegu, South Korea; Univ Nizwa, Nat & Med Plants Res Ctr, Nizwa, Oman | Khan, Muhammad/ABB-9797-2021; Asaf, Sajjad/ABA-3647-2021; Kim, Kyung-Min Kim/C-7007-2014; Kang, Sang-Mo/MBG-7823-2025; Lee, In-Jung/GLS-0432-2022; Khan, Sher/H-2958-2012; Jan, Rahmatullah/AIC-3439-2022 | 57188585606; 56595059900; 26639372800; 57201981969; 56189696900; 34868260300; 16425830900 | ijlee@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 4 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 2.76 | 2025-06-25 | 71 | 88 | GROWTH-PROMOTING RHIZOBACTERIUM; SALINITY STRESS TOLERANCE; HIGH-TEMPERATURE STRESS; SPHINGOMONAS SP LK11; PLANT-GROWTH; HEAT-STRESS; SALICYLIC-ACID; MOLECULAR-MECHANISMS; ANTIOXIDANT SYSTEMS; OXIDATIVE STRESS | Amino Acids; Antioxidants; Ascorbate Peroxidases; Bacillus cereus; Gene Expression Regulation, Plant; Glutathione; Heat-Shock Response; Humic Substances; Lycopersicon esculentum; Plant Proteins; Seedlings; Stress, Physiological; Superoxide Dismutase; Thermotolerance; abscisic acid; ascorbate peroxidase; chlorophyll; glutathione; humic acid; iron; phosphorus; potassium; salicylic acid; superoxide dismutase; amino acid; antioxidant; ascorbate peroxidase; glutathione; plant protein; superoxide dismutase; amino acid analysis; antioxidant activity; Artemisia; Artemisia princeps; Article; Bacillus cereus; bacterial strain; bacterium isolate; bacterium isolation; biomass; Chenopodium; Chenopodium ficifolium; controlled study; Echinochloa crus-galli; fluorescence analysis; heat stress; heat tolerance; inductively coupled plasma mass spectrometry; inoculation; nonhuman; Oenothera biennis; physical chemistry; plant bacterium interaction; plant gene; quantitative analysis; reverse transcription polymerase chain reaction; seedling; SlATG5 gene; SlWRKY33b gene; tomato; upregulation; Bacillus cereus; gene expression regulation; growth, development and aging; heat shock response; heat tolerance; humic substance; metabolism; physiological stress; physiology; seedling; tomato | English | 2020 | 2020-04-30 | 10.1371/journal.pone.0232228 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Factors for starting biosimilar TNF inhibitors in patients with rheumatic diseases in the real world | Background To identify factors for starting biosimilar TNF inhibitors (TNFI) in patients with rheumatic diseases. Methods and finding Using a national claims database, we identified patients with rheumatoid arthritis (RA) or ankylosing spondylitis (AS) who had used TNFIs since they were approved in Korea in 2004. We assessed changes in the proportion of each form of TNFI used between 2004 and 2017. We then selected patients starting on TNFIs between 2013 and 2017 to identify factors for starting biosimilars. In RA (n = 4,216), biosimilars were more likely to be initiated in clinics [odds ratio (OR) 2.54] and in the metropolitan area (OR, 2.02), but were less likely to be initiated in general hospitals (OR 0.40) or orthopedics (OR 0.44). In AS (n = 2,338), biosimilars were common at the hospital level (OR 2.20) and tended to increase over the years (OR 1.16), but were initiated less in orthopedics (OR 0.07). In addition, RA patients were more likely to initiate biosimilars in combination with methotrexate (OR 1.37), but biosimilars were not initiated frequently by patients with higher comorbidity scores (OR 0.97) or receiving glucocorticoids (OR 0.67). The patient factors favoring biosimilar in AS use were not clear. Conclusions In Korea, the proportion of biosimilar TNFIs has increased. Type of institution and physician specialty are more important than patient factors in affecting biosimilar use. In RA, biosimilar TNFIs tend to be initiated in combination with MTX, and are less likely to be initiated in patients taking glucocorticoids or in those with high comorbidities. | Sung, Yoon-Kyoung; Jung, Sun-Young; Kim, Hyoungyoung; Choi, Seongmi; Im, Seul Gi; Lee, Yu Sang; Jang, Eun Jin; Cho, Soo-Kyung | Hanyang Univ, Dept Rheumatol, Hosp Rheumat Dis, Seoul, South Korea; Chung Ang Univ, Coll Pharm, Seoul, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Andong Natl Univ, Dept Informat Stat, Andong, South Korea | 15754508900; 57207445502; 57202108695; 57211676692; 57201022006; 57214139217; 37861741600; 35185890800 | skchomd@hanyang.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.36 | 2025-06-25 | 9 | 9 | INNOVATOR INFLIXIMAB; PARALLEL-GROUP; DOUBLE-BLIND; ARTHRITIS; CT-P13; EFFICACY; SAFETY; SWITCH | Adult; Aged; Antirheumatic Agents; Biosimilar Pharmaceuticals; Female; Humans; Male; Middle Aged; Republic of Korea; Rheumatic Diseases; Treatment Outcome; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; biosimilar agent; glucocorticoid; methotrexate; nonsteroid antiinflammatory agent; tumor necrosis factor inhibitor; antirheumatic agent; biosimilar agent; tumor necrosis factor; tumor necrosis factor inhibitor; adolescent; adult; aged; ankylosing spondylitis; Article; child; comorbidity; data base; drug use; female; general hospital; human; infant; major clinical study; male; newborn; orthopedics; prevalence; rheumatoid arthritis; scoring system; South Korea; middle aged; rheumatic disease; treatment outcome | English | 2020 | 2020-01-24 | 10.1371/journal.pone.0227960 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Genome-wide identification of major genes and genomic prediction using high-density and text-mined gene-based SNP panels in Hanwoo (Korean cattle) | It was hypothesized that single-nucleotide polymorphisms (SNPs) extracted from text-mined genes could be more tightly related to causal variant for each trait and that differentially weighting of this SNP panel in the GBLUP model could improve the performance of genomic prediction in cattle. Fitting two GRMs constructed by text-mined SNPs and SNPs except text-mined SNPs from 777k SNPs set (exp₇₇₇K) as different random effects showed better accuracy than fitting one GRM (Im₇₇₇K) for six traits (e.g. backfat thickness: +0.002, eye muscle area: + 0.014, Warner-Bratzler Shear Force of semimembranosus and longissimus dorsi: + 0.024 and + 0.068, intramuscular fat content of semimembranosus and longissimus dorsi: + 0.008 and +0.018). These results can suggest that attempts to incorporate text mining into genomic predictions seem valuable, and further study using text mining can be expected to present the significant results. | Lee, Hyo Jun; Chung, Yoon Ji; Jang, Sungbong; Seo, Dong Won; Lee, Hak Kyo; Yoon, Duhak; Lim, Dajeong; Lee, Seung Hwan | Chungnam Natl Univ, Div Anim & Dairy Sci, Daejeon, South Korea; Univ Georgia, Dept Anim & Dairy Sci, Athens, GA 30602 USA; Chonbuk Natl Univ, Dept Anim Biotechnol, Jeonju, South Korea; Kyungpook Natl Univ, Dept Anim Sci, Sangju, South Korea; Natl Inst Anim Sci, Anim Genome & Bioinformat, Wonju, South Korea | Seo, Dong-Won/AAI-2578-2020; Lee, SeungHwan/LUY-2745-2024 | 57211315813; 57216463601; 57211317063; 55887111800; 34968239000; 7202875754; 8550517900; 59475424700 | lim_dj@korea.kr;slee46@cnu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 12 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.14 | 2025-06-25 | 9 | 6 | SINGLE NUCLEOTIDE POLYMORPHISM; MEAT QUALITY TRAITS; FUNCTIONAL CANDIDATE GENE; BOS-TAURUS; ASSOCIATION; TENDERNESS; CARCASS; GROWTH; CAPN1; CAST | Animals; Breeding; Cattle; Data Mining; Genome; Genome-Wide Association Study; Genomics; Genotype; Hamstring Muscles; Humans; Models, Genetic; Pedigree; Phenotype; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Republic of Korea; animal experiment; article; controlled study; extraocular muscle; fat content; genetic association; longissimus muscle; major gene; mining; nonhuman; prediction; single nucleotide polymorphism; thickness; animal; biological model; bovine; breeding; data mining; genetics; genome; genome-wide association study; genomics; genotype; growth, development and aging; hamstring muscle; human; metabolism; pedigree; phenotype; quantitative trait locus; single nucleotide polymorphism; South Korea | English | 2020 | 2020-12-02 | 10.1371/journal.pone.0241848 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Health-related quality of life of moderate and severe haemophilia patients: Results of the haemophilia-specific quality of life index in Korea | The assessment of health-related quality of life (HRQoL) as a patient-reported outcome provides information about the patients' general well-being as well as the effects of the disease and its treatment. This study aimed to investigate HRQoL using both generic and haemophilia-specific QoL instruments and to assess the clinical factors associated with HRQoL among haemophilia patients in Korea. In this cross-sectional, multicenter, observational study, moderate-to-severe haemophilia patients aged 8-64 years were recruited between November 2012 and September 2013. The EQ-5D Questionnaire, EQ Visual Analogue Scale, and Haemophilia-Specific QoL (Haemo-QoL) Questionnaire (Haemo-QoL for 8-16 years and Haemo-A-QoL for >= 17 years) were used to assess HRQoL. A total of 605 participants with a mean age of 29.32 +/- 12.62 years were enrolled. The mean Haemo-QoL scores revealed significant differences by age group (children vs. adolescent vs. adult, 26.44 +/- 11.3 vs. 28.88 +/- 11.1 vs. 38.43 +/- 17.7, respectively,p< 0.001). "Sports and leisure," "family planning," and "view" in adults and "perceived support," "friends," and "dealing" in children and adolescents were identified as the domains with the greatest HRQoL impairments. HRQoL was significantly impaired in patients with the following clinical factors: hepatitis, haemophilia-induced disability, bleeding experiences within the last 6 months, joint bleedings within the last 6 months, and haemophilic arthropathy. According to the multivariate regression analysis, HRQoL showed a negative association with the presence of haemophilia-induced disability (beta = 0.222,p< 0.0001), bleeding experiences within the last 6 months (beta = 0.098,p= 0.010), and haemophilic arthropathy (beta = 0.212,p< 0.0001). HRQoL decreased in patients with older age and impaired clinical conditions among moderate-to-severe haemophilia patients in Korea. These study findings may provide significant insights into the adequate haemophilia management using patient-reported measurements. | Baek, Hee Jo; Park, Young Shil; Yoo, Ki Young; Cha, Jin-Hye; Kim, Young-Joo; Lee, Kun Soo | Chonnam Natl Univ, Med Sch, Dept Pediat, Hwasun Hosp, Gwangju, South Korea; Kyung Hee Univ Hosp Gangdong, Dept Pediat, Seoul, South Korea; Korea Hemophilia Fdn, Seoul, South Korea; Pfizer Pharmaceut Korea Ltd, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Pediat, Med Sch, Daegu, South Korea | ; Lee, Kyung-Yil/AFR-4174-2022 | 36724802200; 55494467600; 35209416500; 57194430548; 57207443255; 7501501684 | kslee@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 9 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.45 | 2025-06-25 | 14 | 19 | HEME-A-QOL; INHIBITORS; CHILDREN; UTILITY; ASSOCIATION; INSTRUMENT; MANAGEMENT; ADULTS; IMPACT; EQ-5D | Adolescent; Age Distribution; Child; Hemophilia A; Humans; Multivariate Analysis; Quality of Life; Republic of Korea; Surveys and Questionnaires; blood clotting factor concentrate; adolescent; adult; age distribution; Article; bleeding; child; controlled study; cross-sectional study; disability; disease severity; European Quality of Life 5 Dimensions questionnaire; family planning; friend; hemarthrosis; hemophilia; hemophilia A; hemophilia B; Hemophilia Quality of Life Long Form Kids II; Hemophilia Quality of Life Long Form Kids III; Hemophilia Quality of Life Questionnaire for Adults; hemophilic arthropathy; hepatitis; human; leisure; maintenance therapy; major clinical study; observational study; quality of life; quality of life assessment; South Korea; sport; visual analog scale; hemophilia A; multivariate analysis; pathology; questionnaire | English | 2020 | 2020-09-03 | 10.1371/journal.pone.0238686 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Idiopathic membranous nephropathy in older patients: Clinical features and outcomes | Background Various factors can affect renal and patient outcome in idiopathic membranous nephropathy (iMN). We aimed to identify predictors of renal and patient survival in patients with iMN, with a special focus on outcomes among older patients. Methods We retrieved data on 1,776 patients (mean age 53.0 +/- 14.7 years; 1,075 [60.5%] males) diagnosed with iMN from the Korean GlomeruloNEphritis sTudy (KoGNET), a database compiled from 18 centers in Korea. Results The cohort included 428 (24.1%) patients over 65 years old. Compared to younger patients, this group had lower hemoglobin and serum albumin levels, a higher incidence of nephrotic-range proteinuria, and higher prevalences of hypertension and diabetes. At last follow-up, complete or partial remission rates were not significantly different between the older and younger groups. Older age (HR: 0.98, 95%CI: 0.97-0.99), elevated hemoglobin (HR: 0.82, 95%CI: 0.72-0.93), high serum albumin (HR: 0.66, 95%CI: 0.44-0.99), and a high estimated glomerular filtration rate (HR: 0.96, 95%CI: 0.95-0.97) at biopsy were good predictors of renal outcomes. Significant risk factors for patient survival were older age (HR: 1.04, 95%CI: 1.01-1.10) and hypertension at biopsy (HR: 2.76, 95%CI: 1.30-5.90). Conclusions Older patients with iMN had favorable renal outcomes, but poor patient survival, compared to younger patients. Prognostic information on outcomes in this study might be helpful for optimizing the management of patients with iMN. | Choi, Ji-Young; Chin, Ho Jun; Lee, Hajeong; Bae, Eun Hui; Chang, Tae Ik; Lim, Jeong-Hoon; Jung, Hee-Yeon; Cho, Jang-Hee; Kim, Chan-Duck; Kim, Yong-Lim; Park, Sun-Hee | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Seoul Natl Univ, Coll Med, Dept Internal Med, Seongnam, South Korea; Seoul Natl Univ, Bundang Hosp, Seongnam, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Chonnam Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Ilsan Hosp, Dept Internal Med, Natl Hlth Insurance Serv, Med Ctr, Goyangshi, Gyeonggi Do, South Korea | Lim, Jeong-Hoon/ABE-6003-2020; Park, Sun-Hee/LMN-0033-2024; Chin, Ho/J-5678-2012; Cho, Jang-hee/ABD-3534-2020; Kim, Yong-Lim/AGK-3172-2022 | 7501393222; 23495522400; 36554389800; 59840918700; 33067497300; 55360244300; 57196396467; 7403536291; 8558530700; 55633533600; 7501831741 | sh-park@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 10 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.54 | 2025-06-25 | 16 | 16 | PROGNOSTIC-FACTORS; NEPHROTIC SYNDROME; NATURAL-HISTORY; RENAL-DISEASES; GLOMERULONEPHRITIS; REMISSION | Age Factors; Aged; Aged, 80 and over; Biopsy; Female; Glomerular Filtration Rate; Glomerulonephritis, Membranous; Hemoglobins; Humans; Kidney; Male; Prognosis; Proteinuria; Renal Insufficiency, Chronic; Risk Factors; Serum Albumin; albumin; hemoglobin; hemoglobin; serum albumin; adult; age; aged; albumin blood level; Article; clinical feature; clinical outcome; cohort analysis; diabetes mellitus; estimated glomerular filtration rate; female; hemoglobin blood level; human; hypertension; idiopathic disease; major clinical study; male; membranous glomerulonephritis; proteinuria; remission; risk factor; survival; biopsy; chronic kidney failure; glomerulus filtration rate; kidney; membranous glomerulonephritis; metabolism; pathology; physiology; prognosis; proteinuria; very elderly | English | 2020 | 2020-10-09 | 10.1371/journal.pone.0240566 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | Inflammatory markers for predicting overall survival in gastric cancer patients: A systematic review and meta-analysis | Systemic inflammatory biomarkers have begun to be used in clinical practice to predict prognosis and survival of cancer patients, but the approach remains controversial. We conducted a meta-analysis to determine the predictive value of the c-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), and Glasgow prognostic score (GPS)/modified Glasgow prognostic score (mGPS) in the clinical outcome of gastric cancer (GC) patients. We searched literature databases to identify relevant studies. All articles identified in the search were independently reviewed based on predetermined selection criteria. Meta-analysis was conducted to calculate the hazard ratio (HR) and 95% confidence intervals (CI) of overall survival of the included studies. A total of 41 eligible cohort studies, involving a total of 18,348 patients meeting the inclusion criteria, were considered for meta-analysis. Increases in CRP (HR = 1.654, 95% CI: 1.272-2.151), NLR (HR = 1.605, 95% CI: 1.449-1.779), and GPS/mGPS (HR = 1.648, 95% CI: 1.351-2.011) were significantly associated with poorer survival in patients with GC. Substantial heterogeneities were noted in all three markers (I-2= 86.479%, 50.799%, 69.774%, in CRP, NLR, and GPS/mGPS, respectively). Subgroup analysis revealed a significant positive correlation between each marker and poor survival, regardless of country, study quality, cancer stage, study design, or the inclusion of patients undergoing chemotherapy. This meta-analysis demonstrates that CRP, NLR, and GPS/mGPS are associated with poor survival in patients with GC. Further prospective studies using standardized measurements are warranted to conclude the prognostic value of various inflammatory markers. | Kim, Mi-Rae; Kim, A-Sol; Choi, Hye-In; Jung, Jae-Hun; Park, Ji Yeon; Ko, Hae-Jin | Kyungpook Natl Univ Hosp, Dept Family Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Family Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Family Med, Chilgok Hosp, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea; Kyungpook Natl Univ, Gastr Canc Ctr, Chilgok Hosp, Daegu, South Korea | JUNG, JAEHUN/KHE-5939-2024; Park, Ji Yeon/AAV-2471-2020 | 57218324485; 57203290656; 57202001023; 57218324217; 57196405216; 54393415700 | liveforme@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 7 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.55 | 2025-06-25 | 47 | 49 | GLASGOW PROGNOSTIC SCORE; C-REACTIVE PROTEIN; PREOPERATIVE NEUTROPHIL-LYMPHOCYTE; CURATIVE RESECTION; POSTOPERATIVE SURVIVAL; POOR SURVIVAL; IMMUNE CELLS; RATIO; TUMOR; COMBINATION | Biomarkers; C-Reactive Protein; Humans; Inflammation; Lymphocytes; Neutrophils; Prognosis; Publication Bias; Stomach Neoplasms; Survival Analysis; antineoplastic agent; biological marker; C reactive protein; biological marker; C reactive protein; cancer patient; cancer prognosis; cancer staging; cancer survival; chemotherapy; clinical outcome; correlational study; Glasgow prognostic score; human; meta analysis; modified Glasgow prognostic score; neutrophil lymphocyte ratio; overall survival; prediction; predictive value; Review; scoring system; stomach cancer; systematic review; blood; inflammation; lymphocyte; metabolism; neutrophil; pathology; prognosis; publishing; stomach tumor; survival analysis | English | 2020 | 2020-07-27 | 10.1371/journal.pone.0236445 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Interspecific hierarchies from aggressiveness and body size among the invasive alien hornet, Vespa velutina nigrithorax, and five native hornets in South Korea | The range of the invasive alien hornet,Vespa velutina nigrithorax, has been expanding since its introduction to Korea in 2003. Here, we compare the aggressive behaviors and body size ofV.velutina nigrithoraxwith five native hornet species to identify the interspecific hierarchies that influence the rate of spread of this species. Aggressive behaviors were classified into 11 categories, and each interaction was scored as a win, loss, or tie. We found thatV.velutinawas superior toV.simillimain fights thatV.velutinawon and showed a high incidence of threatening behavior.V.mandariniaoutperformedV.velutinain fights thatV.mandariniawon and grappling behavior was common.V.analiswas superior toV.velutinain fights thatV.analiswon and showed a high degree of threatening behavior.V.crabrowas superior toV.velutinain fights thatV.crabrowon and showed a high rate of threatening behavior.V.dybowskiiwas superior toV.velutinain fights thatV.dybowskiiwon and showed a high incidence of threatening and grappling behaviors. The body size ofV.velutinawas greater thanV.simillima(although not statistically significant) and smaller than all otherVespaspecies. Therefore, according to this study, the low interspecific hierarchies ofV.velutinaseem to be a major cause of the slower spread in Korea than in Europe. However, over time, its density has gradually increased within the forest, where it seems to be overcoming its disadvantages and expanding its range, possibly because the large colonies and good flying abilities of this species help it secure food. | Kwon, Ohseok; Choi, Moon Bo | Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, Daegu, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu, South Korea | 56323648400; 51863232400 | kosinchoi@hanmail.net; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 7 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.63 | 2025-06-25 | 21 | 24 | HYMENOPTERA VESPIDAE; COLONY SIZE; 1ST RECORD; COMPETITION; LEPELETIER; SPREAD; DISPLACEMENT; DISCOVERY; EVOLUTION; HONEYBEES | Aggression; Animals; Behavior, Animal; Body Size; Introduced Species; Republic of Korea; Wasps; aggressiveness; article; body size; controlled study; Europe; flying; forest; human; incidence; nonhuman; South Korea; Vespa velutina; aggression; animal; animal behavior; introduced species; physiology; South Korea; wasp | English | 2020 | 2020-07-28 | 10.1371/journal.pone.0226934 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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