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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Development and Validation of an Online Intervention Program to Augment Psychological Resilience: A Randomized Waitlist-Controlled Trial | Objective Resilience is the ability to bounce back from stressful events using individual and environmental resources. The online intervention program, MoVemEnT, which includes mindfulness training and emotion regulation, was developed to enhance resilience among young adults. Methods Persons without current medical or psychiatric diseases, aged 20-40 years, were recruited. Ninety-six participants were randomly assigned to either the intervention group or a waiting list control (WLC) group, with 45 participants per group completing the program. Results Results demonstrated significant improvements in the intervention group in measures of emotion regulation (Difficulties in Emotion Regulation Scale, DERS) and clinical symptoms of depression (Center for Epidemiological Studies-Depression Scale, CES-D) and anxiety (Generalized Anxiety Disorder-7) compared to the WLC group (all p<0.05). Correlation analyses indicated that improvements in DERS scores were associated with enhanced resilience, as measured by the Korean Resilience Quotient-53 (KRQ-53) and reduced CES-D scores. Reduction in DERS scores can reduce depressive symptoms (CES-D) through direct and indirect pathways via an increase in KRQ-53, according to mediation analyses. Conclusion Our findings reported positive effects of the MoVemEnT program, which includes short videos and brief homework assignments, on resilience in young adults. This study suggests that online intervention programs could offer an opportunity to simultaneously improve general mental health among a large population and may help reduce the burden of face-to-face psychological interventions. | Lee, Sang Won; Nam, Jihyun | Kyungpook Natl Univ, Chilgok Hosp, Dept Psychiat, 807 Hoguk Ro, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Psychiat, Daegu, South Korea; Kyungpook Natl Univ, Clin Om Inst, Daegu, South Korea | 55820414800; 59223674100 | leesangwon.psy@knu.ac.kr; | PSYCHIATRY INVESTIGATION | PSYCHIAT INVEST | 1976-3026 | 22 | 5 | SCIE;SSCI | PSYCHIATRY | 2024 | 1.8 | 63.0 | 0 | 2025-06-11 | 0 | 0 | Online intervention; Emotion regulation; Resilience; Depression | COGNITIVE EMOTION REGULATION; CHILDHOOD MALTREATMENT; DEPRESSION; ABUSE; METAANALYSIS; ASSOCIATION; ADOLESCENTS; STRATEGIES; DISORDER; ANXIETY | Depression; Emotion regulation; Online intervention; Resilience | adult; anxiety; Article; breathing; controlled study; depression; difficulties in emotion regulation scale; eating; emotion; female; Generalized Anxiety Disorder-7; hospital admission; human; Likert scale; major clinical study; male; mediation analysis; mental disease; mindfulness; psychological resilience; questionnaire; randomized controlled trial; single blind procedure; structural equation modeling; validation study; videorecording; web-based intervention; young adult | English | 2025 | 2025-05 | 10.30773/pi.2024.0319 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effects of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition Criteria Changes for Schizophrenia on Diagnoses of First-Episode Schizophrenia Spectrum Disorders | Objective Impact of Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) changes on the criteria for schizophrenia (SZ) has been reported to be minimal in previous studies. However, this could be different in first-episode schizophrenia spectrum disorders (FE-SSDs). We investigated what proportion of patients with FE-SSDs was diagnosed based on the sole presence of bizarre delusions (BDs) or first rank auditory hallucinations (FRAHs). Their alternative diagnosis by the DSM-5 was established and diagnostic stability over 1-year was identified. Methods This was a retrospective review study on the medical records, case report forms for the subjects with FE-SSDs (n=404) participated in the Korea Early Psychosis Study. The two Japanese sites reviewed retrospectively only medical records of the subjects with FE-SSDs (n=103). We used three different definitions of BDs (strict, narrow, and broad) and specified subtypes of Other Specified Schizophrenia spectrum and Other psychotic disorders (OSSOs). To ensure inter-rater reliability between the hospitals, regular zoom meetings were held. Results Forty (7.89%) subjects out of 507 were found to be diagnosed as SSDs based on the sole presence of BDs or FRAHs. All these patients met the criteria of OSSOs and were classified as having pure delusion (n=22), delusion with attenuated auditory hallucinations (AHs) (n=5), pure AHs (n=3) and AHs with attenuated delusion (n=10). The patients with first and second subtypes (n=27) were found to have BDs. The BDs fulfilled mostly strict definitions or satisfied the next broadest definition. The diagnostic stability of FE-OSSOs and its subgroups (first and second subtypes) over 1-year was substantially high (70.27% and 84% respectively). Conclusion These findings suggest that more rigorous diagnostic assessment should be performed especially to differentiate OSSOs from SZ in patients with FE-SSDs and more refined classification of the subtypes for OSSOs considered in the next DSM revision. Psychiatry Investig 2025;22(2):212-217 | Cho, Woori; Kim, Sung-Wan; Won, Seung-Hee; Lee, Bong-Ju; Tsujino, Naohisa; Takubo, Youji; Yamaguchi, Taiju; Nemoto, Takahiro; Li, Ling; Le, Thi-Hung; Rami, Fatima Zahra; Chung, Young-Chul | Jeonbuk Natl Univ Hosp, Dept Psychiat, Jeonju, South Korea; Chonnam Natl Univ, Dept Psychiat, Med Sch, Gwangju, South Korea; Kyungpook Natl Univ Hosp, Dept Psychiat, Daegu, South Korea; Inje Univ, Haeundae Paik Hosp, Dept Psychiat, Busan, South Korea; Saiseikai Yokohamashi Tobu Hosp, Dept Psychiat, Yokohama, Japan; Toho Univ, Fac Med, Dept Neuropsychiat, Tokyo, Japan; Jeonbuk Natl Univ, Med Sch, Dept Psychiat, 20 Geonji Ro, Jeonju 54907, South Korea; Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Res Inst Clin Med, Biomed Res Inst, Jeonju, South Korea | Rami, Fatima/ABS-5222-2022; Chung, Young/AAB-8242-2022 | 59656978500; 47962371200; 35278955600; 59053777300; 12807015900; 57207757808; 54392047700; 35240724300; 57232581000; 57695916500; 57231663300; 55712695800 | chungyc@jbnu.ac.kr; | PSYCHIATRY INVESTIGATION | PSYCHIAT INVEST | 1976-3026 | 22 | 2 | SCIE;SSCI | PSYCHIATRY | 2024 | 1.8 | 63.0 | 0 | 2025-05-07 | 0 | 0 | Bizarre delusions; DSM-5; First-episode schizophrenia spectrum disorders; Other Specified SZ spectrum and Other psychotic disorders | BIZARRE DELUSIONS; 1ST-RANK SYMPTOMS; STABILITY; PSYCHOSIS | Bizarre delusions; DSM-5; First-episode schizophrenia spectrum disorders; Other Specified SZ spectrum and Other psychotic disorders | adult; anxiety; Article; controlled study; delusion; DSM-5; female; first episode of schizophrenia spectrum disorder; human; male; mental disease; mental health; outcome assessment; Positive and Negative Syndrome Scale; psychosis; retrospective study; risk factor; schizophrenia | English | 2025 | 2025-02 | 10.30773/pi.2024.0078 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Psychological Inflexibility, Cognitive Fusion, and Thought-Action Fusion as a Transdiagnostic Construct: Direct Comparisons Among Major Depressive Disorder, Obsessive-Compulsive Disorder, and Healthy Controls | Objective Evidence suggests that acceptance and commitment therapy (ACT) processes function as transdiagnostic factors in both major depressive disorder (MDD) and obsessive-compulsive disorder (OCD) individually. However, few studies have directly compared these two clinical disorders. Therefore, this study aimed to identify potential transdiagnostic factors associated with ACT across MDD, OCD, and healthy control (HC) groups. Methods A total of 34 MDD patients, 43 OCD patients, and 46 HCs were recruited through subway advertisements and outpatient services at a university hospital. Participants completed the Acceptance and Action Questionnaire-II, Cognitive Fusion Questionnaire, thought-action fusion (TAF) scale, and symptom severity scales. Results Direct group comparisons revealed higher psychological inflexibility, cognitive fusion, and likelihood of TAF in the clinical groups compared to the HCs, with no differences between the MDD and OCD groups. These three transdiagnostic factors were variously correlated with both depressive and obsessive-compulsive (OC) symptoms in all groups. Regression analyses demonstrated that the three transdiagnostic factors accounted for 26% of the depressive symptoms in the MDD group (R2=0.26, p=0.028) and 27% of the OC symptoms in the OCD group (R2=0.27, p=0.014). Conclusion These findings from the direct group comparisons of the three groups confirmed that psychological inflexibility, cognitive fusion, and likelihood of TAF are potential transdiagnostic factors that moderately contribute to the primary symptoms of both MDD and OCD. From another perspective, these results also highlight the need to consider how ACT addresses disorder-specific variations beyond what is explained by these transdiagnostic factors in the future. Psychiatry Investig 2025;22(1):93-101 | Lee, Sang Won; Lee, Seung Jae; Choi, Mina | Kyungpook Natl Univ, Sch Med, Dept Psychiat, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Psychiat, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Psychiat, Daegu, South Korea; Kyungpook Natl Univ, Inst Biomed Engn Res, Daegu, South Korea | 55820414800; 58509400200; 58010223000 | jayleemd@knu.ac.kr; | PSYCHIATRY INVESTIGATION | PSYCHIAT INVEST | 1976-3026 | 22 | 1 | SCIE;SSCI | PSYCHIATRY | 2024 | 1.8 | 63.0 | 0 | 2025-05-07 | 0 | 0 | Acceptance and commitment therapy; Processes; Functional analysis; Depression; Obsession; Compulsion. | EXPERIENTIAL AVOIDANCE; PSYCHOMETRIC PROPERTIES; ACTION QUESTIONNAIRE; KOREAN VERSION; MENTAL-HEALTH; ACCEPTANCE; VALIDATION; PREDICTORS; SYMPTOMS; BELIEFS | Acceptance and commitment therapy; Compulsion; Depression; Functional analysis; Obsession; Processes | adult; aged; anxiety; Article; Center for Epidemiological Studies Depression Scale; clinical article; cognition; cognitive behavioral therapy; compulsion; controlled study; cross-sectional study; demographics; depression; emotionality; female; Hamilton Depression Rating Scale; human; major clinical study; major depression; male; middle aged; multiple sclerosis; obsession; obsessive compulsive disorder; psychotherapy; scoring system; test retest reliability | English | 2025 | 2025-01 | 10.30773/pi.2024.0209 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Global-In-Time Discrete Approximation of the Cucker-Smale Model with a Unit Speed Constraint | In this paper, we study the discrete Cucker-Smale model with a unit-speed constraint. For this, we first propose a discrete-time approximation of the Cucker-Smale model with a unit speed constraint (Choi and Ha, in: Commun Math Sci 14:953-972, 2016) using an exponential map in the state space RdxSd-1\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\mathbb {R}d\times \mathbb {S}{d-1}$$\end{document}. Then, we present several sufficient frameworks to guarantee its asymptotic flocking. Moreover, we prove the finite-in-time transition from the discrete system to its continuous counterpart under generic initial data and system parameters. With the help of this result and the asymptotic flocking of the discrete and continuous systems, we also demonstrate the uniform-in-time transition between them. | Han, Jeong Seok; Shim, Woojoo; Ahn, Hyunjin | Myongji Univ, Dept Math, Yongin 17058, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Dept Math Educ, Daegu 41566, South Korea; Myongji Univ, Dept Data Technol, Seoul 03674, South Korea | Shim, Woojoo/GYJ-0778-2022 | 59556615200; 57204943631; 57222812591 | mathjs@mju.ac.kr; wjshim@knu.ac.kr; ahj92@mju.ac.kr; | JOURNAL OF STATISTICAL PHYSICS | J STAT PHYS | 0022-4715 | 1572-9613 | 192 | 2 | SCIE | PHYSICS, MATHEMATICAL | 2024 | 1.2 | 63.1 | 0 | 2025-05-07 | 0 | 0 | Cucker-Smale model; Asymptotic flocking; Unit-speed constraint; Discrete dynamics; Finite-in-time transition; Uniform-in-time transition | MONO-CLUSTER FLOCKING; EMERGENCE; DYNAMICS; TRANSITION; SYSTEM | Asymptotic flocking; Cucker–Smale model; Discrete dynamics; Finite-in-time transition; Uniform-in-time transition; Unit-speed constraint | English | 2025 | 2025-01-18 | 10.1007/s10955-025-03397-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Characterization and genome analyses of the novel phages targeting extraintestinal Escherichia coli clones ST131 and ST410 | The rise of multidrug-resistant (MDR) extraintestinal pathogenic Escherichia coli (ExPEC) poses a severe healthcare threat, necessitating alternative treatment strategies such as bacteriophage therapy. In this study, four lytic phages (EC.W2-9, EC.W5-4, EC.W8-1, and EC.W14-2) were isolated from hospital wastewater and characterized for their efficacy against MDR ExPEC isolates. A total of 44 ExPEC isolates were analyzed, with 41% belonging to sequence type (ST) 131 and 59% to ST410, all exhibiting MDR phenotypes. Among these, 49% produced extended-spectrum β-lactamases (ESBLs), and 86% were identified as carbapenem-resistant E. coli (CREC). Phages EC.W2-9, EC.W8-1, and EC.W14-2 displayed high lytic activity against ST131 (≥ 90% lysis) but were significantly less effective against ST410 (≤ 30% lysis). Phage EC.W5-4 exhibited intermediate efficacy, lysing 78% of ST131 and 23% of ST410 isolates. Morphological and phylogenetic analyses classified EC.W2-9, EC.W5-4, and EC.W14-2 within the Tequatrovirus genus of the Straboviridae family, while EC.W8-1 belonged to the Kuravirus genus of the Podoviridae family. These phages demonstrated favorable biological properties, including short latent periods (10–25 min), high burst sizes (115–158 pfu/cell), and stability across a broad temperature (≤ 70 °C) and pH range (3–10). Genomic analysis (46,328–116,943 bp, 35.2–39.9% G + C content) confirmed the absence of virulence and antibiotic resistance genes. Furthermore, combined phage therapy effectively reduced planktonic and biofilm growth of MDR-ExPEC. These findings demonstrate the potential of these phages as effective therapeutic agents against MDR ExPEC, particularly ST131 and ST410, in combating antibiotic-resistant infections. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2025. | Shamsuzzaman, Md; Choi, Yoon-Jung; Kim, Shukho; Kim, Jungmin | Department of Biomedical Science, School of Medicine, Kyungpook National University, Daegu, South Korea, Department of Microbiology, School of Medicine, Kyungpook National University, (41944) 680 Gukchaebosang-Ro, Jung-Gu, Daegu, South Korea; Department of Microbiology, School of Medicine, Kyungpook National University, (41944) 680 Gukchaebosang-Ro, Jung-Gu, Daegu, South Korea; Department of Biomedical Science, School of Medicine, Kyungpook National University, Daegu, South Korea, Department of Microbiology, School of Medicine, Kyungpook National University, (41944) 680 Gukchaebosang-Ro, Jung-Gu, Daegu, South Korea; Department of Biomedical Science, School of Medicine, Kyungpook National University, Daegu, South Korea, Department of Microbiology, School of Medicine, Kyungpook National University, (41944) 680 Gukchaebosang-Ro, Jung-Gu, Daegu, South Korea | 58493605500; 57220082311; 24341187900; 57211297681 | minkim@knu.ac.kr; | International Microbiology | INT MICROBIOL | 1139-6709 | 1618-1905 | SCIE | MICROBIOLOGY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 2.3 | 63.6 | N/A | 0 | Antibiotic resistance; Biofilm; MDR-ExPEC; Phage therapy; ST131; ST410 | English | Article in press | 2025 | 10.1007/s10123-025-00686-z | 바로가기 | 바로가기 | 바로가기 | |||||||||||
| ○ | ○ | Article | Real-world effectiveness of ixazomib, lenalidomide and dexamethasone in Asians with relapsed/refractory multiple myeloma | Randomized clinical trials have shown ixazomib, lenalidomide and dexamethasone (IRd) to be efficacious and safe in Asian patients with relapsed/refractory multiple myeloma (RRMM); however, real-world data are limited. The APEX study was a multicenter, observational cohort study of IRd conducted at 16 sites across South Korea, Malaysia, and Thailand. Overall, 104 patients treated with IRd during 2016-2023 were enrolled; data were collected by retrospective chart review and 6-month prospective follow-up. Median age at IRd initiation was 64.0 years. The primary endpoints of median time to next treatment (TTNT) and overall response rate (ORR) were 32.1 months and 72.1%, respectively (though ORR varied across countries). The secondary endpoint of median progression-free survival was 27.7 months, while median overall survival was not reached. Median TTNT and ORR were higher in elderly patients (>= 65 and/or >= 70 years) than in the overall population. Adverse events occurred in 90.4% and serious adverse events occurred in 29.8% of all patients; common Grade >= 3 adverse drug reactions were pneumonia (9.6%), neutropenia (7.7%), and gastroenteritis (2.9%). This study demonstrated that IRd was safe and effective in real-world practice in Asia, including for elderly patients, and the results are aligned with TOURMALINE-MM1 and other real-world studies. | Ng, Soo Chin; Moon, Joon-Ho; Park, Sung Soo; Koh, Youngil; Lee, Ji Hyun; Eom, Hyeon-Seok; Shin, Ho-Jin; Jung, Sung Hoon; Do, Young Rok; Wilfred, Gilbert; Husin, Azlan; Kim, Hyo Jung; Wahid, Sfadilah Abdul; Lee, Myung-Won; Heo, Hye-won; Kim, Kihyun; Chuncharunee, Suporn | Subang Jaya Med Ctr, Dept Haematol, Subang Jaya, Malaysia; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Hematol Oncol, Daegu, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Hematol, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Dong A Univ, Dept Hematol Oncol, Dept Internal Med, Coll Med, Busan, South Korea; Natl Canc Ctr, Ctr Hematol Malignancy, Goyang, South Korea; Pusan Natl Univ Hosp, Dept Internal Med, Pusan, South Korea; Chonnam Natl Univ, Hwasun Hosp, Dept Hematol & Oncol, Hwasun, South Korea; Keimyung Univ, Dongsan Med Ctr, Div Hemato Oncol, Daegu, South Korea; Hosp Queen Elizabeth, Dept Med, Kota Kinabalu, Malaysia; Univ Sains Malaysia, Dept Internal Med, George Town, Gelugor, Malaysia; Hallym Univ, Dept Internal Med, Sacred Heart Hosp, Anyang, South Korea; Hosp Canselor Tuanku Muhriz, Pusat Terapi Sel, Kuala Lumpur, Malaysia; Chungnam Natl Univ Hosp, Dept Internal Med, Daejeon, South Korea; Takeda Pharmaceut Korea Co Ltd, Med Affairs, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Sch Med, Seoul, South Korea; Ramathibodi Hosp, Dept Internal Med, Bangkok, Thailand | Husin, Azlan/P-4040-2019 | 57220087005; 56568642700; 57043695200; 58001268600; 56813113800; 35268272400; 16239868400; 55511978300; 8960168300; 57221787957; 49361373000; 7410139194; 59701537500; 55890002700; 59701893200; 57199440300; 6701490020 | kihyunkimk@gmail.com; supornch@gmail.com; | INTERNATIONAL JOURNAL OF HEMATOLOGY | INT J HEMATOL | 0925-5710 | 1865-3774 | 121 | 5 | SCIE | HEMATOLOGY | 2024 | 1.8 | 63.8 | 0 | 2025-05-07 | 0 | 0 | Ixazomib; Real-world; Asia; Relapsed refractory multiple myeloma | ORAL IXAZOMIB | Asia; Ixazomib; Real-world; Relapsed refractory multiple myeloma | Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Asian People; Boron Compounds; Dexamethasone; Female; Glycine; Humans; Lenalidomide; Male; Middle Aged; Multiple Myeloma; Recurrence; Retrospective Studies; Treatment Outcome; bortezomib; carfilzomib; dexamethasone; ixazomib; lenalidomide; antineoplastic agent; boron derivative; dexamethasone; glycine; ixazomib; lenalidomide; adult; aged; Article; cancer survival; clinical practice guideline; cohort analysis; constipation; controlled study; diagnosis to treatment interval; diarrhea; drug efficacy; female; follow up; gastroenteritis; human; International Staging System; leukopenia; line of treatment; major clinical study; Malaysia; male; multicenter study; multiple myeloma; neutropenia; observational study; overall response rate; overall survival; pancytopenia; peripheral neuropathy; pneumonia; progression free survival; randomized controlled trial; retrospective study; sensory neuropathy; South Korea; Thailand; thrombocytopenia; Asian; clinical trial; drug therapy; middle aged; mortality; multiple myeloma; recurrent disease; treatment outcome; very elderly | English | 2025 | 2025-05 | 10.1007/s12185-025-03927-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Two new species of the genus Meroplius Rondani (Diptera: Sepsidae) from Republic of Korea with a key to the Palaearctic species | Two new species, Meroplius angulospinus sp. nov. and Meroplius trifurcus sp. nov., are described from Republic of Korea. The morphological characteristics of both species are provided in detail. Additionally, a key for the identification of Palaearctic species of Meroplius is presented. | Kim, Dongmin; Kim, Young-Kun | Kyungpook Natl Univ, Dept Appl Biol, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea | 57961409800; 57222033782 | donkey7645@naver.com; youngk804@naver.com; | ZOOTAXA | ZOOTAXA | 1175-5326 | 1175-5334 | 5627 | 3 | SCIE | ZOOLOGY | 2024 | 0.9 | 63.8 | N/A | 0 | 0 | Diptera; Sepsidae; Meroplius | RECORD; MITOCHONDRIAL; GENERA | Diptera; Meroplius; Sepsidae | English | 2025 | 2025-04-29 | 10.11646/zootaxa.5627.3.9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | A microglial kinase ITK mediating neuroinflammation and behavioral deficits in traumatic brain injury | Microglia-mediated neuroinflammation has been implicated in the neuropathology of traumatic brain injuries (TBI). Recently, the expression of interleukin-2-inducible T-cell kinase (ITK) has been detected in brain microglia, regulating their inflammatory activities. However, the role of microglial ITK in TBI has not been investigated. In this study, we demonstrate that ITK expression and activation are upregulated in microglia following an injury caused by controlled cortical impact (CCI) - a mouse model of TBI. Pharmacological inhibition of ITK protein or knockdown of microglial ITK gene expression using adeno-associated virus mitigates neuroinflammation and improves neurological outcomes in the CCI model. Additionally, ITK mRNA expression was found to be increased in the brains of patients with chronic traumatic encephalopathy. An ITK inhibitor reduced the activation of inflammatory responses in both human and mouse microglia in vitro. Collectively, these results suggest that microglial ITK plays a pivotal role in neuroinflammation and mediating behavioral deficits following TBI. Thus, targeting the signaling pathway of microglial ITK may exert protective effects by alleviating neuroinflammation associated with TBI. | Afridi, Ruqayya; Bhusal, Anup; Lee, Seung Eun; Hwang, Eun Mi; Ryu, Hoon; Kim, Jong-Heon; Suk, Kyoungho | Kyungpook Natl Univ, Sch Med, Dept Pharmacol, 680 Gukchaebosang St, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, Plus KNU Biomed Convergence Program BK21, Daegu 41944, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea; Korea Inst Sci & Technol, Res Anim Resource Ctr, Virus Facil, Seoul, South Korea; Korea Inst Sci & Technol, Brain Sci Inst, Seoul, South Korea | Hwang, Eun Mi/HHN-3030-2022; Ryu, Hoon/MCJ-9411-2025 | 57200759784; 57200274141; 56323972600; 7101826741; 7202277209; 57203324811; 7005114595 | jongheonkim@knu.ac.kr; ksuk@knu.ac.kr; | MOLECULAR AND CELLULAR NEUROSCIENCE | MOL CELL NEUROSCI | 1044-7431 | 1095-9327 | 132 | SCIE | NEUROSCIENCES | 2024 | 2.4 | 63.9 | 0 | 2025-05-07 | 0 | 0 | Traumatic brain injury; Microglia; Interleukin-2-inducible T -cell kinase; Neuroinflammation | INFLAMMATION; ACTIVATION; TEC | Interleukin-2-inducible T-cell kinase; Microglia; Neuroinflammation; Traumatic brain injury | Animals; Brain Injuries, Traumatic; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; Microglia; Neuroinflammatory Diseases; Protein-Tyrosine Kinases; adeno associated virus vector; bms 509744; gsk 2250665A; gsk 2250665a; interleukin 2 inducible T cell kinase; messenger RNA; protein kinase; protein kinase inhibitor; unclassified drug; emt protein-tyrosine kinase; protein tyrosine kinase; animal experiment; animal model; animal tissue; Article; behavior disorder; chronic traumatic encephalopathy; controlled study; enzyme activation; enzyme inhibition; gene expression; gene knockdown; human; human cell; human tissue; in vitro study; male; microglia; mouse; nervous system inflammation; neuropathology; nonhuman; signal transduction; traumatic brain injury; upregulation; animal; C57BL mouse; etiology; genetics; inflammation; metabolism; traumatic brain injury | English | 2025 | 2025-03 | 10.1016/j.mcn.2025.103994 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Perioperative outcomes in patients with very low-risk endometrial cancer undergoing surgery without lymph node dissection: Results from KGOG 2021 | Aim To evaluate the perioperative outcomes of patients with endometrial cancer meeting the Korean Gynecologic Oncology Group (KGOG) criteria who underwent surgery without lymph node dissection. Methods This study included 153 patients who met the KGOG criteria: (1) endometrioid histology, (2) myometrial invasion 1 cm, and (5) serum CA125 90% of cases, with a conversion rate to laparotomy of 1%. The mean surgery time was 109.37 +/- 37.67 min. Estimated blood loss was minimal (93.74 +/- 93.13 mL), with a mean hemoglobin drop of 1.32 +/- 1.01 g/dL. Transfusions were required in only three patients (2%). Postoperative hospital stays exceeded 2 days in 51% of cases. Lymph node metastasis was observed in just one case (1%). Adverse events included 52 grade 1 and 2 grade 2 events (e.g., headache, paresthesia). Patients undergoing lymph node removal (primarily sentinel lymph node biopsy) had significantly longer surgery times and postoperative hospital stays compared to those without lymph node removal. Conclusion Surgery without lymph node dissection demonstrated excellent perioperative outcomes and minimal adverse events in patients meeting KGOG criteria. | Jeong, Dae Hoon; Kim, Yong Beom; Kim, Kidong; Lee, Jong-Min; Hong, Dae Gy; Bae, Jaeman; Lee, Kwang-Beom; Lee, Chae Hyeong; Lim, Myong Cheol; Kim, Min Kyu | Inje Univ, Busan Paik Hosp, Paik Inst Clin Res, Dept Obstet & Gynecol, Pusan, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Obstet & Gynecol, Seongnam, South Korea; Seoul Natl Univ, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea; Kyung Hee Univ, Hosp Gangdong, Dept Obstet & Gynecol, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Gynecol Canc Ctr, Chilgok Hosp, Daegu, South Korea; Hanyang Univ, Dept Obstet & Gynecol, Coll Med, Seoul, South Korea; Gachon Univ, Gil Med Ctr, Dept Obstet & Gynecol, Coll Med, Incheon, South Korea; Dongguk Univ, Dept Obstet & Gynecol, Ilsan Hosp, Goyang, South Korea; Natl Canc Ctr, Ctr Gynecol Canc, Goyang, South Korea; Sungkyunkwan Univ, Samsung Changwon Hosp, Dept Obstet & Gynecol, Sch Med, Chang Won, South Korea | Kim, Min/ACN-6827-2022 | 59917280600; 59900617300; 35740868200; 57202149183; 26656670100; 35073460200; 34872675300; 35098988800; 57674837500; 56053945200 | kidong.kim.md@gmail.com; | JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH | J OBSTET GYNAECOL RE | 1341-8076 | 1447-0756 | 51 | 6 | SCIE | OBSTETRICS & GYNECOLOGY | 2024 | 1.5 | 63.9 | N/A | 0 | 0 | endometrial neoplasms; lymph node excision; lymphatic metastasis; perioperative care; sentinel lymph node biopsy | LYMPHADENECTOMY; TRIAL; METASTASIS | endometrial neoplasms; lymph node excision; lymphatic metastasis; perioperative care; sentinel lymph node biopsy | Adult; Aged; Endometrial Neoplasms; Female; Humans; Hysterectomy; Lymph Node Excision; Middle Aged; Operative Time; Postoperative Complications; Republic of Korea; CA 125 antigen; hemoglobin; abdominal distension; abdominal pain; adult; arthralgia; Article; bleeding; blood transfusion; body mass; cohort analysis; constipation; diarrhea; disease free survival; dizziness; dysuria; endometrium cancer; fatigue; female; Female Sexual Function Index; follow up; headache; histology; hospitalization; human; laparoscopy; laparotomy; length of stay; lymph node biopsy; lymph node dissection; lymph node metastasis; major clinical study; middle aged; nocturia; nuclear magnetic resonance imaging; oliguria; operative blood loss; overall survival; paresthesia; perioperative care; quality of life; risk factor; sentinel lymph node biopsy; tremor; tumor volume; urinary frequency; urine retention; vagina bleeding; vagina discharge (disease); wound dehiscence; adverse event; aged; endometrium tumor; epidemiology; hysterectomy; lymph node dissection; operation duration; pathology; postoperative complication; procedures; South Korea; surgery | English | 2025 | 2025-06 | 10.1111/jog.16342 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Projections from Regions of the Cerebellar Nuclei Receiving Jaw Muscle Proprioceptive Signals to Trigeminal Motoneurons and Their Premotoneurons in the Rat Pons and Medulla | The cerebellum plays a crucial role in sensorimotor control through cerebellofugal projections from the cerebellar nuclei. However, little is known about the cerebellofugal projection features involved in jaw sensorimotor control, although the dorsolateral parts of the interposed cerebellar nucleus (IntDL) and medial cerebellar nucleus (MedDL) do receive proprioceptive signals bilaterally from rat jaw-closing muscle spindles (JCMSs). This study aimed to detail the cerebellofugal projection features involved in jaw sensorimotor control. Anterograde tracer was injected into regions of the rat IntDL and MedDL receiving JCMS proprioceptive inputs (i.e., jcms-IntDL and jcms-MedDL). Axon terminals arising from the jcms-IntDL were labeled bilaterally with an ipsilateral predominance in several pontomedullary regions, although very few terminals were labeled in the dorsolateral and ventromedial divisions (5dl and 5vm) of the trigeminal motor nucleus. In contrast, terminals from the jcms-MedDL were labeled bilaterally with a contralateral predominance in several pontomedullary regions and a few terminals were labeled in the contralateral 5dl and 5vm. Thus, the projections from the jcms-IntDL and jcms-MedDL were well segregated. Subsequent retrograde tracer injections into the pontomedullary regions demonstrated that amongst the entire cerebellar nuclei the nucleofugal projections principally arose from the IntDL and MedDL. Additionally, many premotoneurons for the 5dl or 5vm were widely labeled in the pontomedullary regions where many axons from the jcms-IntDL or jcms-MedDL terminated. The various connections involving the jcms-IntDL and jcms-MedDL may play a crucial role in jaw sensorimotor control, mainly through indirect cerebellofugal pathways to the 5dl and 5vm via their premotoneurons. | Sato, Fumihiko; Tsutsumi, Yumi; Oka, Ayaka; Furuta, Takahiro; Sohn, Jaerin; Oi, Yuki; Amano, Mai; Morita, Akiko; Uchino, Katsuro; Kato, Takafumi; Bae, Yong Chul; Tachibana, Yoshihisa; Sessle, Barry J.; Yoshida, Atsushi | Osaka Univ, Grad Sch Dent, Dept Systemat Anat & Neurobiol, Suita, Osaka 5650871, Japan; Osaka Univ, Grad Sch Dent, Dept Orthodont & Dentofacial Orthoped, Suita, Osaka 5650871, Japan; Takarazuka Univ Med & Hlth Care, Fac Hlth Care Sci, Dept Acupuncture, Takarazuka, Hyogo 6660162, Japan; Takarazuka Univ Med & Hlth Care, Fac Hlth Care Sci, Dept Phys Therapy, Takarazuka, Hyogo 6660162, Japan; Takarazuka Univ Med & Hlth Care, Fac Hlth Care Sci, Dept Oral Hlth Sci, Takarazuka, Hyogo 6660162, Japan; Osaka Univ, Grad Sch Dent, Dept Oral Physiol, Suita, Osaka 5650871, Japan; Kyungpook Natl Univ, Sch Dent, Dept Anat & Neurobiol, Daegu 700412, South Korea; Kobe Univ, Div Physiol & Cell Biol, Grad Sch Med, Kobe, Hyogo 6500017, Japan; Univ Toronto, Fac Dent, Temerty Fac Med, Toronto, ON M5G 1G6, Canada; Univ Toronto, Temerty Fac Med, Dept Physiol, Toronto, ON M5G 1G6, Canada | Sessle, Barry/AAD-7771-2022 | 37112998700; 57196150893; 36114737500; 7201372674; 39863626400; 59940937700; 59940853800; 59941085400; 35742156800; 57210579311; 59892984700; 47461520500; 7006098345; 55757780066 | yoshida.atsushi.dent@osaka-u.ac.jp; | CEREBELLUM | CEREBELLUM | 1473-4222 | 1473-4230 | 24 | 4 | SCIE | NEUROSCIENCES | 2024 | 2.4 | 63.9 | N/A | 0 | 0 | Cerebellofugal; Interposed cerebellar nucleus; Medial cerebellar nucleus; Muscle spindle; Mastication | BRAIN-STEM; INTERPOSITUS NEURONS; MOTOR NUCLEUS; MASTICATORY MOTONEURONS; HORSERADISH-PEROXIDASE; FASTIGIAL NUCLEUS; SPINDLE AFFERENTS; EYELID RESPONSES; PREMOTOR NEURONS; TACTILE AREAS | Cerebellofugal; Interposed cerebellar nucleus; Mastication; Medial cerebellar nucleus; Muscle spindle | Animals; Cerebellar Nuclei; Jaw; Male; Medulla Oblongata; Motor Neurons; Muscle Spindles; Neural Pathways; Pons; Proprioception; Rats; Rats, Sprague-Dawley; Trigeminal Motor Nucleus; Trigeminal Nuclei; tracer; adult; animal cell; animal experiment; animal tissue; Article; cerebellum nucleus; controlled study; electrophysiology; evoked response; jaw muscle; male; mastication; medulla oblongata; muscle spindle; nerve ending; nonhuman; pons; proprioception; rat; trigeminal motor nucleus; young adult; animal; cytology; innervation; jaw; motoneuron; nerve tract; physiology; Sprague Dawley rat; trigeminal nucleus | English | 2025 | 2025-06-12 | 10.1007/s12311-025-01862-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Long-term outcomes of enzyme replacement therapy from a large cohort of Korean patients with mucopolysaccharidosis IVA (Morquio A syndrome) | Mucopolysaccharidosis (MPS) IVA (Morquio A syndrome) is an autosomal recessive lysosomal storage disorder caused by a mutation affecting the enzyme N-acetylgalactosamine-6-sulfatase (EC 3.1.6.4, GALNS). Enzyme replacement therapy (ERT) has been shown to improve physical performance, quality of life, and respiratory function in patients with MPS IVA; however, owing to the rarity of MPS IVA, data on Korean patient characteristics are limited. This retrospective study reports clinical, radiographic, biochemical, and molecular findings, and analyzes long-term clinical outcomes, from the largest cohort of Korean patients with MPS IVA in a single center. The analysis included 17 patients from 14 families (58.8 % females; median [range] age at diagnosis 5.2 [1.8-33.7] years). The majority of patients (64.7 %) were classified as having a severe phenotype, 23 % had an intermediate phenotype, and 11.8 % had an attenuated phenotype. Skeletal manifestations and radiologic abnormalities at initial diagnosis included gait abnormality (35.3 %), short stature (23.5 %), chest deformity (23.5 %), scoliosis (17.6 %), kyphosis (11.8 %), dysmorphic face (6 %), hip pain (6 %), and leg deformity (6 %). Twelve different GALNS mutations were identified. Patients received ERT for a median (range) 7.4 years (3.0-12.1). Twelve patients reached final adult height, and all patients with the severe/intermediate phenotype had short stature (<3rd percentile). Hemiepiphysiodesis was the most common surgical intervention among patients with the severe/intermediate phenotype. Drug-related adverse events (urticaria, rash, and anaphylaxis) were reported in four patients but were managed with antihistamines or desensitization. At follow-up, patients experienced improvements in functional independence measure score, ejection fraction, and the 6-min walk test compared with the pre-treatment baseline. This study provides real-world evidence for long-term stabilization of functional independence, endurance, and respiratory function among patients with MPS IVA treated with ERT, with no new safety concerns identified. | Sung, Juyoung; Kim, Insung; Im, Minji; Ahn, Yoon Ji; Kim, Sang-Mi; Jang, Ja-Hyun; Park, Hyung-Doo; Jeon, Tae Yeon; Ko, Kyung Rae; Park, Se-Jun; Lee, Jun Hwa; Kim, Eun Young; Cheon, Chong Kun; Kang, Eungu; Moon, Jung-Eun; Sohn, Young Bae; Lin, Hsiang-Yu; Chuang, Chih-Kuang; Lin, Shuan-Pei; Cho, Sung Yoon | Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Pediat, 81 Irwon Ro, Seoul 06351, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Lab Med & Genet, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Radiol, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Orthoped Surg, Seoul, South Korea; Ajou Univ, Samsung Changwon Hosp, Sch Med, Dept Pediat, Suwon, South Korea; Ajou Univ, Chosun Univ Hosp, Sch Med, Dept Pediat, Suwon, South Korea; Ajou Univ, Pusan Natl Univ, Childrens Hosp, Sch Med,Dept Pediat, Suwon, South Korea; Ajou Univ, Korea Univ, Ansan Hosp, Sch Med,Dept Pediat, Suwon, South Korea; Kyungpook Natl Univ Hosp, Dept Pediat, Daegu, South Korea; Ajou Univ, Ajou Univ Hosp, Sch Med, Dept Med Genet, Suwon, South Korea; Mackay Mem Hosp, Dept Pediat, Taipei 10449, Taiwan; Mackay Mem Hosp, Dept Med Res, Div Genet & Metab, Taipei 10449, Taiwan; MacKay Med Coll, Dept Med, New Taipei 252, Taiwan | Lin, Hsiang-Yu/AAG-7798-2020; Kim, YoungHwan/B-2395-2013; Cheon, Chong Kun/GLU-0305-2022 | 57296929100; 59375415100; 57210145237; 58941051600; 57222483209; 35388364100; 35206456500; 17137114800; 55255558400; 57210251009; 59402748500; 57072097200; 26649396100; 57190730666; 57205770947; 56457557700; 35484904800; 7201496330; 55579481000; 57217829002 | nadri1217@naver.com; | MOLECULAR GENETICS AND METABOLISM REPORTS | MOL GENET METAB REP | 2214-4269 | 42 | SCIE | GENETICS & HEREDITY | 2024 | 1.9 | 64.1 | 0 | 2025-05-07 | 0 | 0 | Dysostosis multiplex; Elosulfase alfa; Morquio A syndrome; Enzyme replacement therapy; MPS IVA; Mucopolysaccharidosis | ELOSULFASE ALPHA | Dysostosis multiplex; Elosulfase alfa; Enzyme replacement therapy; Morquio A syndrome; MPS IVA; Mucopolysaccharidosis | antihistaminic agent; creatinine; elosulfase alfa; galns protein; glycosaminoglycan; n acetylgalactosamine 6 sulfatase; unclassified drug; adolescent; adult; adverse drug reaction; airway obstruction; anaphylaxis; Article; assisted ventilation; biochemical analysis; body height; child; clinical article; clinical assessment; clinical feature; clinical outcome; cohort analysis; conduction deafness; desensitization; endurance; enzyme replacement; face dysmorphia; female; follow up; Functional Independence Measure; gait disorder; gene mutation; hearing impairment; heart ejection fraction; hemiepiphysiodesis; hip pain; human; independence; Korean (people); kyphosis; leg disease; long term care; lung disease; male; molecular biology; mucopolysaccharidosis type IVA; musculoskeletal disease; osteotomy; outcome assessment; phase 3 clinical trial (topic); phenotypic variation; positive pressure ventilation; preschool child; radiography; rash; replacement arthroplasty; respiratory function; retrospective study; school child; scoliosis; short stature; six minute walk test; thorax deformity; urticaria | English | 2025 | 2025-03 | 10.1016/j.ymgmr.2025.101189 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Skin condition and barrier function in individuals with a history of atopic dermatitis | Background: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by a multifaceted interplay of factors including skin barrier dysfunction, immunoregulation, environmental influences, and potential infectious agents. While AD lesions commonly ameliorate or resolve with age, individuals with a history of AD often retain susceptibility to irritants even after symptom remission. Objectives: We aimed to investigate skin condition and barrier function of volunteers with a history of AD in order to obtain insight into their skin care. Materials & Methods: A cohort comprising 62 adults participated in this study; 30 subjects with a history of AD and 32 in the control group. Assessment parameters included hydration level, trans-epidermal water loss (TEWL), skin barrier recovery following stratum corneum damage induced by tape-stripping, skin roughness, blood flow, and skin sensitivity. Additionally, the levels of natural moisturizing factor (NMF) and ceramides of inner forearm skin were analysed. Results: No significant differences were observed regarding hydration level, sensitivity score, and TEWL on the cheek area between the AD history and control group. Similarly, comparisons of hydration level, NMF level, ceramide level, and blood flow on the inner forearm skin did not reveal significant differences between the AD history and control group. However, the AD history group displayed significantly higher TEWL values, delayed skin barrier recovery following stratum corneum damage, and skin roughness on the inner forearm skin. Conclusion: Individuals with a history of AD, even after symptom resolution and displaying a normal appearance, present compromised skin barrier function and resistance to barrier damage. | Cho, Eunbyul; Kim, Junghwa; Kang, Baegon; Liu, Kwanghyeon; Cho, Changhui; Lee, Eunyoung; Ha, Jaehyoun; Lim, Kyung-Min | Ewha Womans Univ, Coll Pharm, Seoul, South Korea; Inst Expertise Clin IEC Korea, Suwon, South Korea; Kyungpook Natl Univ, Coll Pharm, Daegu, South Korea | 57204355196; 59715863900; 58068275800; 59812533300; 57204358289; 59714694400; 24503146500; 8916551700 | eunbyulcho510@gmail.com; kmlim@ewha.ac.kr; | EUROPEAN JOURNAL OF DERMATOLOGY | EUR J DERMATOL | 1167-1122 | 1952-4013 | 35 | 1 | SCIE | DERMATOLOGY | 2024 | 1.5 | 64.1 | 0 | 2025-05-07 | 0 | 0 | clinical study; history of atopic dermatitis; skin barrier function; skin condition; skin sensitivity | clinical study; history of atopic dermatitis; skin barrier function; skin condition; skin sensitivity | Adult; Case-Control Studies; Ceramides; Dermatitis, Atopic; Epidermis; Female; Forearm; Humans; Male; Middle Aged; Regional Blood Flow; Skin; Skin Physiological Phenomena; Water Loss, Insensible; Young Adult; ceramide; pyroglutamic acid; urocanic acid; adult; Article; atopic dermatitis; clinical article; cohort analysis; controlled study; female; human; laser Doppler flowmetry; male; questionnaire; skin care; skin disease; skin sensitivity; skin water loss; stratum corneum; blood flow; case control study; epidermis; forearm; functions of the skin and its appendages; metabolism; middle aged; pathology; pathophysiology; skin; thermoregulation; vascularization; young adult | English | 2025 | 2025 (JAN-FEB) | 10.1684/ejd.2025.4810 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Leucaena-Based Alley Cropping System: An Approach for Reclaiming Degraded Land, Reducing the Use of Inorganic Nitrogen Fertilizer, and Improving Crop Productivity | Alley cropping, an agroforestry system that integrates trees and arable crops, holds the potential to improve both crop yields and soil health. It has been found to be effective for upland crops in many countries of the world. However, the utilization of alley cropping to improve soil health in the terrace ecosystem of Bangladesh is poorly understood. Therefore, this study was undertaken to assess the changes in soil biochemical properties and quantify the cabbage yield under three alley widths of Leucaena leucocephala (3.0, 4.5, and 6.0 m size) and five nitrogen (N) levels [0, 40, 80, 120, and 160 kg N ha-1 (0, 25, 50, 75, and 100% of recommended N rates, respectively) with the addition of pruned materials of L. leucocephala (Ipil-ipil)]. The field experiment was conducted following a split-plot design, where alley width was considered as the main-plot factor and N rate as the sub-plot factor. Within each main plot, the five N rates were replicated thrice. Control plots with similar N doses were applied accordingly without addition of pruned materials to compare the results with alley cropping. Data were collected on the biochemical properties of the soil [soil pH, organic carbon (C), total N, available phosphorus (P), exchangeable potassium (K), microbial biomass C, and biomass N] and the yield of cabbage quantified [edible head weight (kg plant-1) and head yield (t ha-1)] under different alley widths and control. Findings revealed that organic C, total N, available P, exchangeable K, microbial biomass C, and biomass N in the topsoil exhibited maximum values in the L. leucocephala-based alley plot, which is proved to be a possible solution of restoration of degradable land. Additionally, L. leucocephala-based alley cropping improved the soil pH, indicating a potential avenue for more-sustainable land management practices. Results also showed that alley widths and N rates have significant effects on cabbage (Brassica oleracea L. var. capitata) yield. Alley width of 6.0 m along with 100% N provided the highest cabbage yield followed by 75% N in 6.0 m alley, and the control with 100%. The wider alley minimizes tree-crop competition, allowing for optimal cabbage production. These aforementioned results suggest that alley cropping with L. leucocephala is a promising approach to enhance soil fertility and crop productivity in the terrace ecosystem of Bangladesh. | Suhag, Md.; Ahamed, Tofayel; Das, Ashim Kumar; Rahman, Md. Abiar; Rahman, Md. Mizanur; Miah, Md. Giashuddin | Gazipur Agr Univ, Dept Agroforestry & Environm, Gazipur 1706, Bangladesh; Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Appl Biosci, Daegu 41566, South Korea; ICRAF, Ctr Int Forestry Res CIFOR, Country Off, Gazipur 1706, Bangladesh; Gazipur Agr Univ, Dept Soil Sci, Gazipur 1706, Bangladesh | Das, Ashim Kumar/ABB-6751-2020; Rahman, Md. Mizanur/AAA-1082-2021 | 59347359300; 24469752700; 57211473983; 55597087441; 57054208000; 7006652093 | suhag@gau.edu.bd; tofayel@bsmrau.edu.bd; ashim@knu.ac.kr; abiar@bsmrau.edu.bd; mizan@bsmrau.edu.bd; giash1960@bsmrau.edu.bd; | NITROGEN | NITROGEN-BASEL | 2504-3129 | 6 | 2 | ESCI | ENVIRONMENTAL SCIENCES | 2024 | 2.3 | 64.3 | 0 | 0 | agroforestry; alley cropping; cabbage; Leucaena leucocephala; soil properties | CARBON SEQUESTRATION; GLIRICIDIA-SEPIUM; EXTRACTION METHOD; ORGANIC-MATTER; SOIL FERTILITY; MAIZE; COMPETITION; LEUCOCEPHALA; PERFORMANCE; MITIGATION | agroforestry; alley cropping; cabbage; Leucaena leucocephala; soil properties | English | 2025 | 2025-04-11 | 10.3390/nitrogen6020025 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | The Beneficial Effects of CGK012 Against Lipopolysaccharide-Induced Inflammation | This study investigates the protective effects of CGK012 [(7S)-(+)-cyclopentyl carbamic acid 8,8-dimethyl-2-oxo-6,7-dihydro-2H,8H-pyrano[3,2-g]chromen-7-yl-ester], a small-molecule inhibitor targeting the Wnt/beta-catenin signaling pathway, against inflammatory responses elicited by lipopolysaccharide (LPS). The study evaluated the influence of CGK012 on heme oxygenase (HO)-1, cyclooxygenase (COX)-2, and inducible nitric oxide synthase (iNOS) expressions in LPS-stimulated human endothelial cells. It examined its effects on iNOS, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-1 beta in LPS-challenged mice. CGK012 treatment resulted in increased HO-1 production, inhibited nuclear factor-kappa B activation, and decreased the levels of COX-2/PGE2 and iNOS/NO. Additionally, CGK012 reduced signal transducer and activator of transcription-1 phosphorylation and facilitated Nrf2 nuclear translocation and binding to antioxidant response elements, culminating in reduced IL-1 beta production in LPS-exposed human umbilical vein endothelial cells. Notably, the inhibitory effect of CGK012 on iNOS/NO was reversed upon HO-1 knockdown via RNA interference. In vivo, CGK012 markedly attenuated iNOS expression in lung tissue and decreased TNF-alpha levels in bronchoalveolar lavage fluid. These findings underscore the anti-inflammatory potential of CGK012, suggesting its therapeutic promise for conditions characterized by pathological inflammation. | Lee, Jinhee; Heo, Jong Beom; Heo, Hae Joon; Nam, Gaewon; Song, Gyu Yong; Bae, Jong-Sup | Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, CMRI, Daegu, South Korea; Chungnam Natl Univ, Coll Pharm, 80 Daehak Ro, Daejon 41566, South Korea; Seowon Univ, Dept Biocosmet Sci, Cheongju, South Korea | 59150416200; 57414219300; 59272316400; 57202034846; 58856541700; 16021543200 | gysong@cnu.ac.kr; baejs@knu.ac.kr; | JOURNAL OF MEDICINAL FOOD | J MED FOOD | 1096-620X | 1557-7600 | 28 | 2 | SCIE | CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY;NUTRITION & DIETETICS | 2024 | 2 | 64.4 | 0 | 2025-05-07 | 0 | 0 | CGK012; endothelium; iNOS; p-STAT-1 | CELLS | CGK012; endothelium; iNOS; p-STAT-1 | Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Heme Oxygenase-1; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Interleukin-1beta; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide Synthase Type II; Tumor Necrosis Factor-alpha; antiinflammatory agent; beta actin; cgk 012; cyclooxygenase 2; cyclopentyl carbamic acid 8,8 dimethyl 2 oxo 6,7 dihydro 2h,8h pyrano[3,2 g]chromen 7 yl ester; dexamethasone; dimethyl sulfoxide; heme oxygenase 1; immunoglobulin enhancer binding protein; inducible nitric oxide synthase; interleukin 1beta; kelch like ECH associated protein 1; lamin B; lipopolysaccharide; nitric oxide; penicillin G; prostaglandin E2; protein inhibitor; small interfering RNA; STAT1 protein; streptomycin; superoxide dismutase; transcription factor Nrf2; tumor necrosis factor; unclassified drug; antiinflammatory agent; cyclooxygenase 2; heme oxygenase 1; immunoglobulin enhancer binding protein; inducible nitric oxide synthase; interleukin 1beta; lipopolysaccharide; transcription factor Nrf2; tumor necrosis factor; animal experiment; animal model; antioxidant responsive element; Article; binding affinity; clinical evaluation; controlled study; drug effect; endothelial dysfunction; endothelium; endothelium cell; enzyme activation; enzyme linked immunosorbent assay; gene knockdown; human; human cell; in vitro study; JAK-STAT signaling; lipopolysaccharide-induced lung inflammation; lung injury; lung lavage; lung parenchyma; male; mouse; nonhuman; protein expression; protein phosphorylation; RNA interference; signal transduction; treatment indication; umbilical vein endothelial cell; animal; C57BL mouse; drug therapy; genetics; inflammation; metabolism | English | 2025 | 2025-02-01 | 10.1089/jmf.2024.k.0194 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Gait patterns during tripping in young adult males: Unconscious selection of recovery strategy depending on the relative position of the center of mass (CoM) and base of support (BoS) | This study investigated gait recovery strategies in response to obstacle-induced tripping among young adult males, focusing on the interaction between the base of support (BoS) and the center of mass (CoM). Four primary recovery strategies were identified and classified: Elevating-in (E-in), elevating-out (E-out), lowering-in (L-in), and lowering-out (L-out). Our findings reveal a crucial correlation between the position of the CoM and the supporting foot during tripping incidents, which significantly influences the choice of recovery strategy. Detailed analysis of activation timings within the elevating and lowering strategies during the swing phase confirmed the effectiveness of classifying these strategies based on the relative positions of the BoS and CoM. The elevating strategy, particularly when the supporting foot is near the obstacle and the CoM is within the BoS, shows an increased risk of falling. Furthermore, the activation timings for both elevating and lowering strategies across the swing phase were consistent with previous research, validating the classification of four distinct strategies rather than the traditionally recognized three. These findings highlight the essential role of the positional relationship between the BoS and CoM in selecting appropriate recovery strategies. This study provides critical insights that can enhance the development of fall prevention programs and improve gait stability, offering new approaches for designing assistive devices and training programs aimed at reducing fall risks during gait interruptions caused by obstacles. Future research will build on these findings to develop more effective fall prevention strategies and interventions. | Kim, Jeongmin; Yi, Hak; Hwang, Donghwan; Kim, Kyoung Tae; Cho, Jang-Hyuk; Lee, Yongkoo | Kyungpook Natl Univ, Sch Mech Engn, Daegu, South Korea; Korea Inst Machinery & Mat, Daegu Res Ctr Med Devices & Green Energy, Daegu, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Med Device Dev Ctr, Daegu, South Korea; Keimyung Univ, Dong San Hosp, Sch Med, Dept Rehabil Med, Daegu, South Korea | 58805344500; 59815734600; 57219450749; 57397440300; 57217207863; 57189226732 | ylee2012@kimm.re.kr; | JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY | J MECH SCI TECHNOL | 1738-494X | 1976-3824 | 39 | 3 | SCIE | ENGINEERING, MECHANICAL | 2024 | 1.7 | 64.6 | 0 | 2025-05-07 | 0 | 0 | Tripping over; Trip recovery strategy; Obstacle; Supporting foot position; Base of support (BoS); Center of mass (CoM) | LOWER-EXTREMITY; KINEMATICS; BALANCE; STABILITY; RESPONSES; WALKING; PHASE; FALL | Base of support (BoS); Center of mass (CoM); Obstacle; Supporting foot position; Trip recovery strategy; Tripping over | Gait analysis; Human rehabilitation engineering; Base of support; Base of supports; Center of mass; Centers-of-mass; Obstacle; Recovery strategies; Supporting foot position; Trip recovery strategy; Tripping over; Young adults; Risk assessment | English | 2025 | 2025-03 | 10.1007/s12206-025-0247-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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