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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Diagonal and off-diagonal blocks of positive definite partitioned matrices | We obtain new relations for the blocks of a positive semidefi-[(A) (X)(X* ) (B) ]partitioned into four blocks in M-n. A consequence is |X + X*| = 2, the constant 1/4 cannot be replaced by any smaller one. Several eigenvalue inequalities for general matrices follow from our result. We can also derive from (0.1) some triangle type inequalities, for instance for three contractions, |S+T + R | <= I-3(4)+|S|+|T|+|R| (0.2) where I stands for the identity. We conjecture that the con-stant 3/4 is optimal. (c) 2023 Elsevier Inc. All rights reserved. | Bourin, Jean-Christophe; Lee, Eun-Young | Univ Franche Comte, CNRS, LmB, F-25000 Besancon, France; Kyungpook Natl Univ, Dept Math, Daegu 702701, South Korea | 6602591041; 55371789400 | jcbourin@univ-fcomte.fr;eylee89@knu.ac.kr; | LINEAR ALGEBRA AND ITS APPLICATIONS | LINEAR ALGEBRA APPL | 0024-3795 | 1873-1856 | 684 | SCIE | MATHEMATICS, APPLIED;MATHEMATICS | 2024 | 1.1 | 22.3 | 0 | 2025-05-07 | 1 | 1 | Partitioned matrices; Positive definite matrices; Matrix geometric mean; Schur product | SINGULAR-VALUE INEQUALITIES | Matrix geometric mean; Partitioned matrices; Positive definite matrices; Schur product | Eigenvalues and eigenfunctions; Eigenvalue inequalities; Geometric mean; matrix; Matrix geometric mean; Matrix-geometric; Partitioned matrix; Positive definite; Positive semidefinite matrices; Positive-definite matrices; Schur product; Matrix algebra | English | 2024 | 2024-03-01 | 10.1016/j.laa.2023.12.012 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Healthcare professionals' perspectives towards the digitalisation of paediatric growth hormone therapies: expert panels in Italy and Korea | Introduction: To analyse the perspectives of healthcare professionals (HCPs) regarding the acceptance of digital health solutions for growth hormone (GH) deficiency care. This study identified factors impacting HCPs' intent to use and recommend digital solutions supporting recombinant-human growth hormone (r-hGH) therapy in Italy and Korea with a use case of connected drug delivery system (Aluetta (R) with Smartdot (TM)) integrated in a platform for GH treatment support (the Growzen (TM) digital health ecosystem). Methods: Participatory workshops were conducted in Rome, Italy, and Seoul, Korea, to collect the perspectives of 22 HCPs on various predefined topics. HCPs were divided into two teams, each moderated by a facilitator. The workshops progressed in five phases: introduction of the project and experts, capturing views on the current context of digitalisation, perceived usefulness and ease of use of Aluetta (R) with Smartdot (TM), exploration of the perception of health technology evolution, and combined team recommendations. Data shared by HCPs on technology acceptance were independently analysed using thematic analysis, and relevant findings were shared and validated with experts. Results: HCPs from both Italy and Korea perceived Aluetta (R) with Smartdot (TM) and the Growzen (TM) based digital health ecosystem as user-friendly, intuitive, and easy-to-use solutions. These solutions can result in increased adherence, a cost-effective healthcare system, and medication self-management. Although technology adoption and readiness may vary across countries, it was agreed that using digital solutions tailored to the needs of users may help in data-driven clinical decisions and strengthen HCP-patient relationships. Conclusion: HCPs' perspectives on the digitalisation in paediatric GH therapies suggested that digital solutions enable automatic, real-time injection data transmission to support adherence monitoring and evidence-based therapy, strengthen HCP-patient relationships, and empower patients throughout the GH treatment process. | Romero, Octavio Rivera; Chae, Hyun Wook; Faienza, Maria Felicia; Vergani, Edoardo; Cheon, Chong Kun; Di Mase, Raffaella; Frasca, Francesco; Lee, Hae Sang; Giavoli, Claudia; Kim, Jihyun; Klain, Antonella; Moon, Jung Eun; Iezzi, Maria Laura; Yeh, James; Aversa, Antonio; Rhie, Young-Jun; Koledova, Ekaterina | Univ Seville, Elect Tecnol Dept, Seville, Spain; Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Pediat, Seoul, South Korea; Pediat Hosp Giovanni XXIII, Unit Endocrinol & Rare Endocrine Dis, Bari, Italy; Univ Bari A Moro, Dept Precis & Regenerat Med & Ionian Area, Bari, Italy; Univ Cattolica Sacro Cuore, Agostino Gemelli Polyclin Fdn, Dept Translat Med & Surg, IRCCS, Rome, Italy; Pusan Natl Univ, Childrens Hosp, Dept Pediat, Yangsan, South Korea; Univ Hosp Federico II, Pediat Endocrinol Unit, Naples, Italy; Univ Catania, Garibaldi Nesima Hosp, Dept Clin & Expt Med, Endocrinol Sect, Catania, Italy; Ajou Univ, Sch Med, Dept Pediat, Suwon, South Korea; Fdn IRCCS Ca Granda Osped Maggiore Policlin, Endocrinol Unit, Milan, Italy; Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy; Dongguk Univ, Dept Pediat, Ilsan Hosp, Goyang, South Korea; Santobono Pausilipon Childrens Hosp, Pediat Endocrinol Unit, Naples, Italy; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Pediat, Daegu, South Korea; Univ Aquila, San Salvatore Hosp, Pediat Dept, Laquila, Italy; Merck Ltd, Seoul, South Korea; Merck KGaA, Darmstadt, Germany; Magna Graecia Univ Catanzaro, Dept Expt & Clin Med, Sect Endocrinol, Catanzaro, Italy; Korea Univ, Coll Med, Dept Pediat, Seoul, South Korea; Merck Healthcare KGaA, Global Med Affairs Cardiometab & Endocrinol, Darmstadt, Germany | Vergani, Edoardo/JCE-0461-2023; Rhie, Young-Jun/AAV-4929-2020; Faienza, Maria/K-6779-2016; Frasca, Francesco/J-1332-2018; Cheon, Chong Kun/GLU-0305-2022; lee, Hae Sang/AFL-6833-2022; Giavoli, Claudia/K-8844-2016 | 27968036000; 36983744100; 6602459943; 57202962104; 26649396100; 35387885200; 6602706627; 56561306600; 7801362258; 57226166154; 56952840400; 57205770947; 8604629800; 59230668400; 7004221169; 36470933600; 8549887500 | orivera@us.es;ekaterina.koledova@merckgroup.com; | FRONTIERS IN ENDOCRINOLOGY | FRONT ENDOCRINOL | 1664-2392 | 15 | SCIE | ENDOCRINOLOGY & METABOLISM | 2024 | 4.6 | 22.3 | 0 | 2025-05-07 | 0 | 0 | adherence monitoring; Aluetta (R) Smartdot (TM); connected device; digital health; healthcare digitalisation; recombinant human growth hormone | adherence monitoring; Aluetta<sup>®</sup>Smartdot<sup>™</sup>; connected device; digital health; healthcare digitalisation; recombinant human growth hormone | human growth hormone; somatotropin injection pen; Article; caregiver; cost effectiveness analysis; digital health; digital health technology; digitalization; doctor patient relationship; drug delivery system; ecosystem; empowerment; government; health care personnel; health care system; health center; health ecosystem; hormonal therapy; human; human experiment; pediatrics; perception; qualitative analysis; self concept; self medication; thematic analysis; workshop | English | 2024 | 2024-07-10 | 10.3389/fendo.2024.1419667 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Improving the diagnostic performance of inexperienced readers for thyroid nodules through digital self-learning and artificial intelligence assistance | Background Data-driven digital learning could improve the diagnostic performance of novice students for thyroid nodules. Objective To evaluate the efficacy of digital self-learning and artificial intelligence-based computer-assisted diagnosis (AI-CAD) for inexperienced readers to diagnose thyroid nodules. Methods Between February and August 2023, a total of 26 readers (less than 1 year of experience in thyroid US from various departments) from 6 hospitals participated in this study. Readers completed an online learning session comprising 3,000 thyroid nodules annotated as benign or malignant independently. They were asked to assess a test set consisting of 120 thyroid nodules with known surgical pathology before and after a learning session. Then, they referred to AI-CAD and made their final decisions on the thyroid nodules. Diagnostic performances before and after self-training and with AI-CAD assistance were evaluated and compared between radiology residents and readers from different specialties. Results AUC (area under the receiver operating characteristic curve) improved after the self-learning session, and it improved further after radiologists referred to AI-CAD (0.679 vs 0.713 vs 0.758, p<0.05). Although the 18 radiology residents showed improved AUC (0.7 to 0.743, p=0.016) and accuracy (69.9% to 74.2%, p=0.013) after self-learning, the readers from other departments did not. With AI-CAD assistance, sensitivity (radiology 70.3% to 74.9%, others 67.9% to 82.3%, all p<0.05) and accuracy (radiology 74.2% to 77.1%, others 64.4% to 72.8%, all p <0.05) improved in all readers. Conclusion While AI-CAD assistance helps improve the diagnostic performance of all inexperienced readers for thyroid nodules, self-learning was only effective for radiology residents with more background knowledge of ultrasonography. Clinical Impact Online self-learning, along with AI-CAD assistance, can effectively enhance the diagnostic performance of radiology residents in thyroid cancer. | Lee, Si Eun; Kim, Hye Jung; Jung, Hae Kyoung; Jung, Jing Hyang; Jeon, Jae-Han; Lee, Jin Hee; Hong, Hanpyo; Lee, Eun Jung; Kim, Daham; Kwak, Jin Young | Yonsei Univ, Yongin Severance Hosp, Coll Med, Dept Pediat, Yongin, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Radiol, Daegu, South Korea; CHA Univ, Bundang Med Ctr, Dept Radiol, Seongnam, South Korea; Kyungpook Natl Univ, Dept Surg, Chilgok Hosp, Daegu, South Korea; Kyungpook Natl Univ, Dept Endocrinol, Chilgok Hosp, Daegu, South Korea; Keimyung Univ, Dongsan Hosp, Dept Radiol, Daegu, South Korea; Yonsei Univ, Dept Computat Sci & Engn, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Endocrinol, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Radiol, Seoul, South Korea | ; Hong, Hanpyo/KHU-7470-2024; lee, si eun/AFD-5116-2022 | 57196483474; 57203506201; 12240058100; 59218728900; 36910340400; 59218451400; 58817499500; 59109567500; 55508760100; 7202648908 | ant637@knuh.kr;docjin@yuhs.ac; | FRONTIERS IN ENDOCRINOLOGY | FRONT ENDOCRINOL | 1664-2392 | 15 | SCIE | ENDOCRINOLOGY & METABOLISM | 2024 | 4.6 | 22.3 | 0 | 2025-04-16 | 1 | 0 | thyroid cancer; artificial intelligence; ultrasound; learning; digital learning | DATA SYSTEM; RISK STRATIFICATION; ULTRASONOGRAPHY; MANAGEMENT | artificial intelligence; digital learning; learning; thyroid cancer; ultrasound | adult; area under the curve; Article; artificial intelligence; correlation coefficient; diagnostic accuracy; e-learning; echography; family medicine; female; human; learning; middle aged; pathology; radiologist; receiver operating characteristic; sensitivity and specificity; systematic review; thyroid cancer; thyroid nodule; thyroid papillary carcinoma; training; ultrasound | English | 2024 | 2024-07-02 | 10.3389/fendo.2024.1372397 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Linearity of Cartan and Wasserstein means | The convex cone of positive definite Hermitian matrices has two important Riemannian geometries, where the para-metrized weighted geometric (alternatively, Cartan) and Wasserstein means appear as the corresponding geodesics. The major problem with which this paper is concerned is lin-earity of Cartan and Wasserstein geodesics; when the Cartan (resp. Wasserstein) geodesic between two positive definite ma-trices A and B does lie in the space spanned by them and what the path in the plane to which it corresponds is. We settle the problem completely for the Cartan geometry and partially for the Wasserstein geometry. We show that their linearity problems for linearly independent A and B are equivalent to the solvability of the following equations for positive reals x and y with xy < 1/4 respectively (xA+ yB)(-1) = yA(-1) + xB(-1), (AB)(1/2 )+ (BA)(1/2)/ (2) = xA + y(B). | Choi, Hayoung; Kim, Sejong; Lim, Yongdo | Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea; Chungbuk Natl Univ, Dept Math, Cheongju 28644, South Korea; Sungkyunkwan Univ, Dept Math, Suwon 440746, South Korea | Choi, Hayoung/U-7046-2019 | 56942685000; 37111100300; 55931749600 | hayoung.choi@knu.ac.kr;skim@chungbuk.ac.kr;ylim@skku.edu; | LINEAR ALGEBRA AND ITS APPLICATIONS | LINEAR ALGEBRA APPL | 0024-3795 | 1873-1856 | 681 | SCIE | MATHEMATICS, APPLIED;MATHEMATICS | 2024 | 1.1 | 22.3 | 0 | 2025-05-07 | 0 | 0 | Positive definite matrix; Geometric and Wasserstein mean; Ostrowski-Taussky inequality; Matrix with positive real part; Lyapunov equation | MATRICES; GEOMETRY | Geometric and Wasserstein mean; Lyapunov equation; Matrix with positive real part; Ostrowski-Taussky inequality; Positive definite matrix | Cones; Lyapunov functions; Convex cone; Geometric and wasserstein mean; Lyapunov equation; matrix; Matrix with positive real part; Ostrowski; Ostrowski-taussky inequality; Positive real; Positive-definite matrices; Real part; Matrix algebra | English | 2024 | 2024-01-15 | 10.1016/j.laa.2023.10.020 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | 10-Eicosanol Alleviates Patulin-Induced Cell Cycle Arrest and Apoptosis by Activating AKT (Protein Kinase B) in Porcine Intestinal Epithelial Cells | Patulin (PAT) is a fungal toxin prevalent in apples and apple products and associated with several toxic effects, potentially harming multiple organs, including the kidneys, liver, and colon. However, the precise molecular mechanism through which PAT affects the intestines remains comprehensively unclear. Therefore, this study aims to investigate the molecular effects of PAT on the intestinal epithelium. Gene expression profiling was conducted, hypothesizing that PAT induces cell cycle arrest and apoptosis through the PI3K-Akt signaling pathway. Cell cycle analysis, along with Annexin-V and propidium iodide staining, confirmed that PAT induced G2/M phase arrest and apoptosis in IPEC-J2 cells. Additionally, PAT activated the expression of cell cycle-related genes (CDK1, CCNB1) and apoptosis-related genes (BCL6, CASP9). Treatment with SC79, an AKT activator, mitigated cell cycle arrest and apoptosis. To identify natural products that could mitigate the harmful effects of PAT in small intestinal epithelial cells in pigs, the high-throughput screening of a natural product library was conducted, revealing 10-Eicosanol as a promising candidate. In conclusion, our study demonstrates that 10-Eicosanol alleviates PAT-induced cell cycle arrest and apoptosis in IPEC-J2 cells by activating AKT. | Lee, Chae Hyun; Shin, Sangsu; Lee, Sang In | Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju Si 37224, Gyeongsangbuk D, South Korea; Kyungpook Natl Univ, Res Inst Innovat Anim Sci, SangjuSi 37224, Gyeongsangbuk D, South Korea | 59444074800; 55490360000; 57203597336 | dlcogus9602@naver.com;sss@knu.ac.kr;silee78@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 16 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 0.38 | 2025-05-07 | 1 | 1 | patulin; intestinal epithelial cell; gene expression profiling; cell cycle arrest; apoptosis; 10-eicosanol | CHAIN FATTY ALCOHOL; MYCOTOXIN PATULIN; PI3K/AKT; RAT; ZEARALENONE; TOXICITY | 10-eicosanol; apoptosis; cell cycle arrest; gene expression profiling; intestinal epithelial cell; patulin | Animals; Apoptosis; Cell Cycle Checkpoints; Cell Line; Epithelial Cells; Intestinal Mucosa; Patulin; Proto-Oncogene Proteins c-akt; Signal Transduction; Swine; lipocortin 5; patulin; propidium iodide; protein kinase B; patulin; protein kinase B; Akt signaling; animal cell; animal tissue; apoptosis; Article; biological phenomena and functions concerning the entire organism; cell cycle; cell cycle arrest; cell viability; controlled study; differential gene expression; flow cytometry; follow up; gene expression profiling; high throughput screening; human; human cell; IC50; intestine epithelium; intestine epithelium cell; IPEC-J2 cell line; KEGG; M phase cell cycle checkpoint; mRNA expression level; nonhuman; Pi3K/Akt signaling; pig; real time polymerase chain reaction; RNA sequencing; ubiquitination; WST-1 assay; animal; cell cycle checkpoint; cell line; drug effect; epithelium cell; intestine mucosa; metabolism; pig; signal transduction | English | 2024 | 2024-08 | 10.3390/ijms25168597 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | 4-Hexylresorcinol Enhances Glut4 Expression and Glucose Homeostasis via AMPK Activation and Histone H3 Acetylation | This study investigates the potential of 4-hexylresorcinol (4HR) as a novel antidiabetic agent by assessing its effects on blood glucose levels, Glut4 expression, AMPK phosphorylation, and Histone H3 acetylation (Ac-H3) in the liver. In vitro experiments utilized Huh7 and HepG2 cells treated with varying concentrations of 4HR. Glut4, p-AMPK, and Ac-H3 expression levels were quantified via Western blotting. Additionally, GAPDH activity and glucose uptake were evaluated. In vivo experiments employed streptozotocin (STZ)-induced diabetic rats, with or without 4HR treatment, monitoring blood glucose, body weight, and hepatic levels of Glut4, p-AMPK, and Ac-H3. In vitro, 4HR treatment increased GAPDH activity and glucose uptake. Elevated Glut4, p-AMPK, and Ac-H3 levels were observed 8 h after 4HR administration. Inhibition of p-AMPK using compound C reduced 4HR-mediated Glut4 expression. In STZ-induced diabetic rats, 4HR significantly upregulated Glut4, p-AMPK, and Ac-H3 expression in the liver. Periodic 4HR injections mitigated weight loss and lowered blood glucose levels in STZ-injected animals. Histological analysis revealed increased glycogen storage in hepatocytes of the 4HR-treated group. Overall, 4HR enhanced Glut4 expression through upregulation of AMPK activity and histone H3 acetylation in vitro and in vivo, improving hepatic glucose homeostasis and suggesting potential as a candidate for diabetes treatment. | Che, Xiangguo; Oh, Ji-Hyeon; Kang, Yei-Jin; Kim, Dae-Won; Kim, Seong-Gon; Choi, Je-Yong; Garagiola, Umberto | Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Biochem & Cell Biol, Daegu 41944, South Korea; Gangneung Wonju Natl Univ, Coll Dent, Dept Oral & Maxillofacial Surg, Kangnung 25457, South Korea; Gangneung Wonju Natl Univ, Coll Dent, Dept Oral Biochem, Kangnung 25457, South Korea; Univ Milan, Sch Dent, Biomed Surg & Oral Sci Dept, Maxillofacial & Dent Unit, I-20122 Milan, Italy | ; Choi, Je-Yong/AAR-7334-2021; Kim, Seong-Gon/AAF-7553-2020; Garagiola, Umberto/AAM-2220-2020 | 54792660600; 55957562000; 57211458783; 56194913400; 27171913700; 7501391068; 8583947500 | xiangguo0622@naver.com;oms@gwnu.ac.kr;kyj292@hanmail.net;kimdw@gwnu.ac.kr;kimsg@gwnu.ac.kr;jechoi@knu.ac.kr;umberto.garagiola@unimi.it; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 22 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 0.76 | 2025-05-07 | 2 | 2 | 4-hexylresorcinol; AMPK; Glut; diabetic complications; histone deacetylase inhibitor | CELL-PROLIFERATION; OXIDATIVE STRESS; INHIBITOR; DYSFUNCTION; PROTEIN; COMPLICATIONS; TRANSCRIPTION; METABOLISM; APOPTOSIS; PATHWAYS | 4-hexylresorcinol; AMPK; diabetic complications; Glut; histone deacetylase inhibitor | Acetylation; AMP-Activated Protein Kinases; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose; Glucose Transporter Type 4; Hep G2 Cells; Histones; Homeostasis; Humans; Hypoglycemic Agents; Liver; Male; Phosphorylation; Rats; Resorcinols; beta actin; glucose; glucose transporter 1; glucose transporter 4; glyceraldehyde 3 phosphate dehydrogenase; hexylresorcinol; histone H3; human insulin; hydroxymethylglutaryl coenzyme A reductase kinase; antidiabetic agent; glucose; glucose transporter 4; histone; hydroxymethylglutaryl coenzyme A reductase kinase; resorcinol derivative; animal experiment; animal model; apoptosis; Article; blood glucose monitoring; body weight; controlled study; endoplasmic reticulum; enzyme linked immunosorbent assay; glucose blood level; glucose homeostasis; glucose metabolism; glucose transport; glycogen analysis; Golgi complex; Hep-G2 cell line; histone acetylation; Huh-7 cell line; human; human cell; immunohistochemistry; in vitro study; insulin dependent diabetes mellitus; liver cell; liver tissue; male; nerve fiber transport; nonhuman; protein expression; rat; streptozotocin-induced diabetes mellitus; transcription initiation; upregulation; Western blotting; acetylation; animal; drug effect; drug therapy; experimental diabetes mellitus; homeostasis; liver; metabolism; phosphorylation | English | 2024 | 2024-11 | 10.3390/ijms252212281 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | A Novel Fabrication of Heterogeneous Saponified Poly(Vinyl Alcohol)/Pullulan Blend Film for Improved Wound Healing Application | In this study, a novel film of poly(vinyl alcohol) (PVA)/pullulan (PULL) with improved surface characteristics was prepared from poly(vinyl acetate) (PVAc)/PULL blend films with various mass ratios after the saponification treatment in a heterogeneous medium. According to proton nuclear magnetic resonance (1H-NMR), Fourier transform infrared, and X-ray diffraction results, it was established that the successful fabrication of saponified PVA/PULL (100/0, 90/10, and 80/20) films could be obtained from PVAc/PULL (100/0, 90/10, and 80/20) films, respectively, after 72 h saponification at 50 degrees C. The degree of saponification calculated from 1H-NMR analysis results showed that fully saponified PVA was obtained from all studied films. Improved hydrophilic characteristics of the saponified films were revealed by a water contact angle test. Moreover, the saponified films showed improved mechanical behavior, and the micrographs of saponified films showed higher surface roughness than the unsaponified films. This kind of saponified film can be widely used for biomedical applications. Moreover, the reported saponified film dressing extended the lifespan of dressing as determined by its self-healing capacity and considerably advanced in vivo wound-healing development, which was attributed to its multifunctional characteristics, meaning that saponified film dressings are promising candidates for full-thickness skin wound healing. | Yeasmin, Sabina; Jung, Jae Hoon; Lee, Jungeon; Kim, Tae Young; Yang, Seong Baek; Kwon, Dong-Jun; Kim, Myoung Ok; Yeum, Jeong Hyun | Kyungpook Natl Univ, Dept Biofibers & Biomat Sci, Daegu 41566, South Korea; Gyeongsang Natl Univ, Res Inst Green Energy Convergence Technol, Jinju 52828, South Korea; Gyeongsang Natl Univ, Dept Mat Sci & Convergence Technol, Jinju 52828, South Korea; Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea | ; Yang, Seong/AAP-1745-2020 | 57216565706; 58476748000; 57559595700; 57208461628; 56258526300; 36550312000; 8934745900; 6602257098 | yeasminsabina44@yahoo.com;jjdwognsz@naver.com;dlwjddjs2@gmail.com;xodud10301@naver.com;sbyang@gnu.ac.kr;rorrir@empas.com;ok4325@knu.ac.kr;jhyeum@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 0.42 | 2025-04-16 | 1 | 1 | poly(vinyl acetate); poly(vinyl alcohol); blend film; casting process; heterogeneous saponification; hydrophilic film; degree of saponification | POLYVINYL-ALCOHOL; PULLULAN; NANOFIBERS | blend film; casting process; degree of saponification; heterogeneous saponification; hydrophilic film; poly(vinyl acetate); poly(vinyl alcohol) | Bandages; Ethanol; Glucans; Poly A; Polyvinyl Alcohol; Polyvinyl Chloride; asiaticoside; bromethol; fusidate sodium; polyvinyl acetate; polyvinyl alcohol; pullulan; alcohol; glucan; polyadenylic acid; polyvinyl alcohol; polyvinylchloride; pullulan; Article; body weight loss; chemical structure; contact angle; dihydroxylation; Fourier transform infrared spectroscopy; human; hydrogen bond; lifespan; nuclear magnetic resonance spectroscopy; optical microscopy; phase separation; proton nuclear magnetic resonance; saponification; surface area; tensile strength; thermogravimetry; thermostability; thickness; wound care; wound fluid; wound healing; wound healing rate; X ray diffraction | English | 2024 | 2024-01 | 10.3390/ijms25021026 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Advancing Cardiovascular Drug Screening Using Human Pluripotent Stem Cell-Derived Cardiomyocytes | Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have emerged as a promising tool for studying cardiac physiology and drug responses. However, their use is largely limited by an immature phenotype and lack of high-throughput analytical methodology. In this study, we developed a high-throughput testing platform utilizing hPSC-CMs to assess the cardiotoxicity and effectiveness of drugs. Following an optimized differentiation and maturation protocol, hPSC-CMs exhibited mature CM morphology, phenotype, and functionality, making them suitable for drug testing applications. We monitored intracellular calcium dynamics using calcium imaging techniques to measure spontaneous calcium oscillations in hPSC-CMs in the presence or absence of test compounds. For the cardiotoxicity test, hPSC-CMs were treated with various compounds, and calcium flux was measured to evaluate their effects on calcium dynamics. We found that cardiotoxic drugs withdrawn due to adverse drug reactions, including encainide, mibefradil, and cetirizine, exhibited toxicity in hPSC-CMs but not in HEK293-hERG cells. Additionally, in the effectiveness test, hPSC-CMs were exposed to ATX-II, a sodium current inducer for mimicking long QT syndrome type 3, followed by exposure to test compounds. The observed changes in calcium dynamics following drug exposure demonstrated the utility of hPSC-CMs as a versatile model system for assessing both cardiotoxicity and drug efficacy. Overall, our findings highlight the potential of hPSC-CMs in advancing drug discovery and development, which offer a physiologically relevant platform for the preclinical screening of novel therapeutics. | Oh, Jisun; Kwon, Oh-Bin; Park, Sang-Wook; Kim, Jun-Woo; Lee, Heejin; Kim, Young-Kyu; Choi, Eun Ji; Jung, Haiyoung; Choi, Dong Kyu; Oh, Bae Jun; Min, Sang-Hyun | Daegu Gyeongbuk Med Innovat Fdn K Med Hub, New Drug Dev Ctr NDDC, Daegu 41061, South Korea; Chonnam Natl Univ, Sch Dent, Dept Oral Biochem, Gwangju 61186, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Aging Convergence Res Ctr, Daejeon 34141, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Immunotherapy Res Ctr, Daejeon 34141, South Korea; Korea Univ Sci & Technol UST, Dept Funct Genom, Daejeon 34113, South Korea; Kyungpook Natl Univ, Sch Life Sci & Biotechnol, BK21 FOUR KNU Creat Biores Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Innovat Pharmaceut Sci, Daegu 41566, South Korea | Choi, dongKyu/LKL-2959-2024; Park, Sang-Wook/LEM-5116-2024; CHOI, EUN JI/HTP-2403-2023 | 56311554100; 55197926100; 57191670899; 57215818625; 57202875112; 57212222953; 59866757400; 7403029998; 57215816624; 59236722900; 7202852238 | joh@kmedihub.re.kr;kob325@kmedihub.re.kr;swpark@chonnam.ac.kr;margarte@hanmail.net;leeheejin@kmedihub.re.kr;kimyk0114@kmedihub.re.kr;cej2017@kribb.re.kr;haiyoung@kribb.re.kr;dongkyu@knu.ac.kr;baejun.oh@kmedihub.re.kr;shmin03@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 14 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 0.76 | 2025-05-07 | 4 | 4 | human pluripotent stem cells; cardiomyocytes; drug screening; cardiovascular pharmacology; high-throughput assays | CARDIAC DIFFERENTIATION; MATURATION; DISCOVERY | cardiomyocytes; cardiovascular pharmacology; drug screening; high-throughput assays; human pluripotent stem cells | Calcium; Calcium Signaling; Cardiotoxicity; Cardiovascular Agents; Cell Differentiation; Drug Evaluation, Preclinical; HEK293 Cells; High-Throughput Screening Assays; Humans; Myocytes, Cardiac; Pluripotent Stem Cells; calcium channel blocking agent; cardiovascular agent; cetirizine; diltiazem; encainide; flecainide; mibefradil; potassium channel HERG; ritonavir; sodium channel blocking agent; verapamil; calcium; cardiovascular agent; adult; Article; calcium cell level; calcium signaling; calcium transport; cardiac muscle cell; cardiotoxicity; cell differentiation; controlled study; drug development; drug efficacy; drug exposure; energy yield; female; genetic predisposition; high throughput analysis; high throughput screening; human; human cell; major clinical study; male; mitochondrial respiration; phenotype; pluripotent stem cell; scanning electron microscopy; sodium current; stem cell; treatment outcome; Western blotting; cardiotoxicity; cell differentiation; cytology; drug effect; HEK293S cell line; metabolism; preclinical study; procedures | English | 2024 | 2024-07 | 10.3390/ijms25147971 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Alzheimer's Disease Pathology and Assistive Nanotheranostic Approaches for Its Therapeutic Interventions | Alzheimer's disease (AD) still prevails and continues to increase indiscriminately throughout the 21st century, and is thus responsible for the depreciating quality of health and associated sectors. AD is a progressive neurodegenerative disorder marked by a significant amassment of beta-amyloid plaques and neurofibrillary tangles near the hippocampus, leading to the consequent loss of cognitive abilities. Conventionally, amyloid and tau hypotheses have been established as the most prominent in providing detailed insight into the disease pathogenesis and revealing the associative biomarkers intricately involved in AD progression. Nanotheranostic deliberates rational thought toward designing efficacious nanosystems and strategic endeavors for AD diagnosis and therapeutic implications. The exceeding advancements in this field enable the scientific community to envisage and conceptualize pharmacokinetic monitoring of the drug, sustained and targeted drug delivery responses, fabrication of anti-amyloid therapeutics, and enhanced accumulation of the targeted drug across the blood-brain barrier (BBB), thus giving an optimistic approach towards personalized and precision medicine. Current methods idealized on the design and bioengineering of an array of nanoparticulate systems offer higher affinity towards neurocapillary endothelial cells and the BBB. They have recently attracted intriguing attention to the early diagnostic and therapeutic measures taken to manage the progression of the disease. In this article, we tend to furnish a comprehensive outlook, the detailed mechanism of conventional AD pathogenesis, and new findings. We also summarize the shortcomings in diagnostic, prognostic, and therapeutic approaches undertaken to alleviate AD, thus providing a unique window towards nanotheranostic advancements without disregarding potential drawbacks, side effects, and safety concerns. | Dey, Anuvab; Ghosh, Subhrojyoti; Rajendran, Ramya Lakshmi; Bhuniya, Tiyasa; Das, Purbasha; Bhattacharjee, Bidyabati; Das, Sagnik; Mahajan, Atharva Anand; Samant, Anushka; Krishnan, Anand; Ahn, Byeong-Cheol; Gangadaran, Prakash | Indian Inst Technol Guwahati, Dept Biosci & Bioengn, Gauhati 781039, Assam, India; Indian Inst Technol Madras, Dept Biotechnol, Chennai 600036, Tamil Nadu, India; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Natl Inst Technol Durgapur, Dept Biotechnol, Durgapur 713209, West Bengal, India; Presidency Univ, Dept Life Sci, Kolkata 700073, West Bengal, India; Jain Univ, Sch Sci, Dept Biotechnol, Bangalore, Karnataka, India; St Xaviers Coll Autonomous, Dept Biotechnol, Kolkata 700016, W Bengal, India; Adv Ctr Treatment Res & Educ Canc ACTREC, Navi Mumbai, Maharashtra, India; Natl Inst Technol, Dept Biotechnol & Med Engn, Rourkela 769008, Orissa, India; Univ Free State, Fac Hlth Sci, Sch Pathol, Dept Chem Pathol, ZA-9300 Bloemfontein, South Africa; Kyungpook Natl Univ, Chilgok Hosp, Dept Nucl Med, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, KNU Convergence Educ Program Biomed Sci Creat Futu, Daegu 41944, South Korea | Krishnan, Anand/C-5178-2015; Rajendran, Ramya/AAV-6338-2021; DEY, ANUVAB/HSI-3094-2023; Ghosh, Subhrojyoti/KDN-2006-2024; Gangadaran, Prakash/AAV-3102-2021 | 57225769107; 58035427200; 57195318729; 58563671500; 59250676900; 59326543600; 58189112800; 58653487800; 59326713200; 57488883300; 7202791511; 54393130400 | anuvab2000dey@gmail.com;subhrojyotighosh8@gmail.com;ramyag@knu.ac.kr;tiyasa28082000@gmail.com;purbasha.mantai@gmail.com;bidyabatibhattacharjee@gmail.com;sagnikd525@gmail.com;anushkas2709@gmail.com;krishnana1@ufs.ac.za;abc2000@knu.ac.kr;prakashg@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 17 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 0.51 | 2025-05-07 | 6 | 5 | Alzheimer's disease; neurodegeneration; nanotheranostic; nanomedicine; personalized therapy | BLOOD-BRAIN-BARRIER; IMPAIRED AXONAL-TRANSPORT; DRUG-DELIVERY; AMYLOID-BETA; NEURODEGENERATIVE DISEASES; MITOCHONDRIAL DYSFUNCTION; ZNO NANOPARTICLES; TAU; LIPOSOMES; STRATEGIES | Alzheimer’s disease; nanomedicine; nanotheranostic; neurodegeneration; personalized therapy | Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Drug Delivery Systems; Humans; Nanoparticles; Theranostic Nanomedicine; biological marker; nanoparticle; amyloid beta protein; Alzheimer disease; blood brain barrier; degenerative disease; diagnosis; drug delivery system; endothelium cell; hippocampus; human; nanomedicine; nerve degeneration; neurofibrillary tangle; nonhuman; personalized medicine; pharmacokinetics; review; animal; blood brain barrier; chemistry; drug therapy; metabolism; pathology; procedures; theranostic nanomedicine; therapy | English | 2024 | 2024-09 | 10.3390/ijms25179690 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Anti-Obesity and Anti-Diabetic Effects of Ostericum koreanum (Ganghwal) Extract | "Ganghwal" is a widely used herbal medicine in Republic of Korea, but it has not been reported as a treatment strategy for obesity and diabetes within adipocytes. In this study, we determined that Ostericum koreanum extract (OKE) exerts an anti-obesity effect by inhibiting adipogenesis and an anti-diabetic effect by increasing the expression of genes related to glucose uptake in adipocytes and inhibiting alpha-glucosidase activity. 3T3-L1 preadipocytes were differentiated for 8 days in methylisobutylxanthine, dexamethasone, and insulin medium, and the effect of OKE was confirmed by the addition of 50 and 100 mu g/mL of OKE during the differentiation process. This resulted in a reduction in lipid accumulation and the expression of PPAR gamma (Peroxisome proliferator-activated receptor gamma) and C/EBP alpha (CCAAT enhancer binding protein alpha). Significant activation of AMPK (AMP-activated protein kinase), increased expression of GLUT4 (Glucose Transporter Type 4), and inhibition of alpha-glucosidase activity were also observed. These findings provide the basis for the anti-obesity and anti-diabetic effects of OKE. In addition, OKE has a significant antioxidant effect. This study presents OKE as a potential natural product-derived material for the treatment of patients with metabolic diseases such as obesity- and obesity-induced diabetes. | Lee, Eunbi; Nam, Ju-Ock | Kyungpook Natl Univ, Dept Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Tailored Food Technol, Daegu 41566, South Korea | 57798039800; 7201496105 | 21eunbi@naver.com;namjo@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 9 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 0.76 | 2025-05-07 | 1 | 2 | Ostericum koreanum; Ganghwal; anti-obesity; anti-diabetes; antioxidant effect | ALPHA-GLUCOSIDASE; OXIDATIVE STRESS; OBESITY; ADIPOGENESIS; SUPPRESSION; DOCKING; AMYLASE; SYSTEM; AMPK | anti-diabetes; anti-obesity; antioxidant effect; Ganghwal; Ostericum koreanum | 3T3-L1 Cells; Adipocytes; Adipogenesis; alpha-Glucosidases; AMP-Activated Protein Kinases; Animals; Anti-Obesity Agents; Antioxidants; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Crassulaceae; Glucose Transporter Type 4; Glycoside Hydrolase Inhibitors; Hypoglycemic Agents; Lipid Metabolism; Mice; Obesity; Plant Extracts; PPAR gamma; alpha glucosidase; dexamethasone; glucose transporter 4; hydroxymethylglutaryl coenzyme A reductase kinase; insulin; isobutylmethylxanthine; peroxisome proliferator activated receptor gamma; alpha glucosidase; antidiabetic agent; antiobesity agent; antioxidant; CCAAT enhancer binding protein alpha; glucose transporter 4; glycosidase inhibitor; hydroxymethylglutaryl coenzyme A reductase kinase; peroxisome proliferator activated receptor gamma; plant extract; adipogenesis; animal cell; antidiabetic activity; antiobesity activity; Article; gene expression; glucose transport; lipid storage; liquid chromatography-mass spectrometry; medicinal plant; molecular docking; mouse; nonhuman; Ostericum koreanum; proadipocyte; 3T3-L1 cell line; adipocyte; adipogenesis; animal; cell differentiation; chemistry; Crassulaceae; drug effect; genetics; lipid metabolism; metabolism; obesity | English | 2024 | 2024-05 | 10.3390/ijms25094908 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Antiseptic Functions of CGK012 against HMGB1-Mediated Septic Responses | High mobility group box 1 (HMGB1), a protein with important functions, has been recognized as a potential therapeutic target for the treatment of sepsis. One possible mechanism for this is that inhibiting HMGB1 secretion can exert antiseptic effects, which can restore the integrity of the vascular barrier. (7S)-(+)-cyclopentyl carbamic acid 8,8-dimethyl-2-oxo-6,7-dihydro-2H,8H-pyrano[3,2-g]chromen-7-yl-ester (CGK012) is a newly synthesized pyranocoumarin compound that could function as a novel small-molecule inhibitor of the Wnt/beta-catenin signaling pathway. However, no studies have yet determined the effects of CGK012 on sepsis. We investigated the potential of CGK012 to attenuate the excessive permeability induced by HMGB1 and enhance survival rates in a mouse model of sepsis with reduced HMGB1 levels following lipopolysaccharide (LPS) treatment. In both LPS-stimulated human endothelial cells and a mouse model exhibiting septic symptoms due to cecal ligation and puncture (CLP), we assessed proinflammatory protein levels and tissue damage biomarkers as indicators of reduced vascular permeability. CGK012 was applied after induction in human endothelial cells exposed to LPS and the CLP-induced mouse model of sepsis. CGK012 effectively mitigated excessive permeability and suppressed HMGB1 release, resulting in improved vascular stability, decreased mortality, and enhanced histological conditions in the mouse model of CLP-induced sepsis. In conclusion, our findings indicate that CGK012 treatment in mice with CLP-induced sepsis diminished HMGB1 release and increased the survival rate, suggesting its potential as a pharmaceutical intervention for sepsis. | Park, Yun Jin; Heo, Jong Beom; Choi, Yoon-Jung; Cho, Sanghee; Lee, Taeho; Song, Gyu Yong; Bae, Jong-Sup | Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea; AREZ Co Ltd, Daejeon 34036, South Korea | 58784741900; 57414219300; 57222871850; 58784915200; 57204032003; 58856541700; 16021543200 | dbswls101@naver.com;songmeom@gmail.com;cyjjh0609@naver.com;sanghee3472@naver.com;tlee@knu.ac.kr;gysong@cnu.ac.kr;baejs@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 5 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 0.76 | 2025-05-07 | 3 | 2 | CGK012; sepsis; HMGB1; endothelium | NF-KAPPA-B; GROUP BOX 1; IMPROVES SURVIVAL; CELLS; ZINGERONE; HMGB1; MEDIATOR; HMG-1 | CGK012; endothelium; HMGB1; sepsis | Animals; Anti-Infective Agents, Local; Carbamates; Coumarins; Disease Models, Animal; HMGB1 Protein; Human Umbilical Vein Endothelial Cells; Humans; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Sepsis; advanced glycation end product receptor; alanine aminotransferase; antiinfective agent; antiinflammatory agent; aspartate aminotransferase; biological marker; cgk 012; creatinine; cyclopentyl carbamic acid 8,8 dimethyl 2 oxo 6,7dihydro 2h,8h pyrano[3,2 g]chromen 7 yl ester; endothelial leukocyte adhesion molecule 1; high mobility group B1 protein; immunoglobulin enhancer binding protein; intercellular adhesion molecule 1; interleukin 1beta; interleukin 6; lactate dehydrogenase; lipopolysaccharide; mitogen activated protein kinase 1; mitogen activated protein kinase 3; mitogen activated protein kinase p38; nitrogen; pathogen associated molecular pattern; pyranocoumarin derivative; sirtinol; sirtuin 1; toll like receptor 2; toll like receptor 4; tumor necrosis factor; unclassified drug; urea; vascular cell adhesion molecule 1; zingerone; carbamic acid; CGK012; coumarin derivative; high mobility group B1 protein; lipopolysaccharide; topical antiinfective agent; alanine aminotransferase blood level; animal experiment; animal model; animal tissue; antiinflammatory activity; antimicrobial activity; Article; aspartate aminotransferase blood level; blood vessel permeability; blood vessel wall; cecal ligation and puncture-induced sepsis; cell adhesion; cell viability; controlled study; creatinine blood level; cytokine production; deacetylation; down regulation; drug efficacy; drug structure; drug synthesis; gene overexpression; human; human cell; in vitro study; in vivo study; kidney injury; lactate dehydrogenase blood level; leukocyte migration; lipopolysaccharide-induced sepsis; liver injury; lung parenchyma; male; MAPK signaling; mouse; neutrophil; NF kB signaling; nonhuman; protein acetylation; protein phosphorylation; protein secretion; survival rate; tissue injury; umbilical vein endothelial cell; urea nitrogen blood level; animal; C57BL mouse; disease model; metabolism; sepsis | English | 2024 | 2024-03 | 10.3390/ijms25052976 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Assessing the Risks of Pesticide Exposure: Implications for Endocrine Disruption and Male Fertility | Pesticides serve as essential tools in agriculture and public health, aiding in pest control and disease management. However, their widespread use has prompted concerns regarding their adverse effects on humans and animals. This review offers a comprehensive examination of the toxicity profile of pesticides, focusing on their detrimental impacts on the nervous, hepatic, cardiac, and pulmonary systems, and their impact on reproductive functions. Additionally, it discusses how pesticides mimic hormones, thereby inducing dysfunction in the endocrine system. Pesticides disrupt the endocrine system, leading to neurological impairments, hepatocellular abnormalities, cardiac dysfunction, and respiratory issues. Furthermore, they also exert adverse effects on reproductive organs, disrupting hormone levels and causing reproductive dysfunction. Mechanistically, pesticides interfere with neurotransmitter function, enzyme activity, and hormone regulation. This review highlights the effects of pesticides on male reproduction, particularly sperm capacitation, the process wherein ejaculated sperm undergo physiological changes within the female reproductive tract, acquiring the ability to fertilize an oocyte. Pesticides have been reported to inhibit the morphological changes crucial for sperm capacitation, resulting in poor sperm capacitation and eventual male infertility. Understanding the toxic effects of pesticides is crucial for mitigating their impact on human and animal health, and in guiding future research endeavors. | Uwamahoro, Claudine; Jo, Jae-Hwan; Jang, Seung-Ik; Jung, Eun-Ju; Lee, Woo-Jin; Bae, Jeong-Won; Kwon, Woo-Sung | Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Sangju 37224, South Korea | Bae, Jeong-Won/AAH-4932-2021; Kwon, Woo-Sung/J-4391-2014; Kwon, Woo-Sung/J-6731-2019 | 58844996200; 58346379700; 58346379800; 57377289200; 57377138800; 57211231093; 54383715800 | claudineuwa20@gmail.com;ocjallk@naver.com;todwnl5787@naver.com;red0787@naver.com;wj9059lee@naver.com;jwbae1822@gmail.com;wskwon@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 13 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 1.03 | 2025-05-07 | 10 | 10 | pesticides; sperm capacitation; male infertility; endocrine system dysfunction | INDUCED OXIDATIVE STRESS; PIPERONYL BUTOXIDE; IN-VITRO; ORGANOCHLORINE PESTICIDES; REPRODUCTIVE-SYSTEM; ALPHA-CYPERMETHRIN; MALE-INFERTILITY; SPERM MOTILITY; TNF-ALPHA; CHLORPYRIFOS | endocrine system dysfunction; male infertility; pesticides; sperm capacitation | Animals; Endocrine Disruptors; Environmental Exposure; Fertility; Humans; Infertility, Male; Male; Pesticides; Reproduction; Sperm Capacitation; neurotransmitter; pesticide; endocrine disruptor; pesticide; adult; endocrine disease; endocrine system; enzyme activity; exposure; female genital system; heart failure; hormonal regulation; hormone determination; human; male; male fertility; male infertility; nonhuman; oocyte; pest control; review; sperm; sperm capacitation; adverse event; animal; drug effect; environmental exposure; fertility; male infertility; reproduction; sperm capacitation | English | 2024 | 2024-07 | 10.3390/ijms25136945 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Chronological Dynamics of Neuroinflammatory Responses in a High-Fat Diet Mouse Model | Obesity is known to affect various tissues and contribute to conditions such as neuroinflammation. However, the specific mechanisms and time-dependent progression of these effects across different tissues remain unclear. In this study, we monitored gene expression at intervals to examine the effects of a high-fat diet (HFD) on brain, liver, adipose, and muscle tissues in male C57/BJ mice, with a particular focus on neuroinflammation. Early inflammatory responses exhibit a progression that starts in the liver, extends to adipose tissue, and subsequently involves muscle and brain tissues. Although the brain did not show significant gene expression of inflammatory responses, mechanisms leading to neuroinflammation increased after 24 weeks, possibly through systemic chronic inflammation (SCI). Notably, mitochondrial complex I activity serves as a biomarker to indicate the inflammatory transition from the liver to adipose and other tissues caused by SCI. These similar gene expression dynamics were also observed in the hippocampus of Alzheimer's patients and in an Alzheimer's mouse model treated with a HFD. These results suggest that initially, the brain suppresses inflammatory responses, including interferon-gamma (IFN-gamma), more than other tissues in response to a HFD. However, at the onset of SCI, the brain eventually exhibits inflammatory dynamics similar to those of other tissues. This underscores the significance of our findings, indicating that the early kinetics of chronic IFN-gamma response and mitochondrial complex I activity inhibition serve as crucial biomarkers, emerging early in various conditions, including obesity and aging. | Bae, Heekyong R.; Shin, Su-Kyung; Lee, Ji-Yoon; Choi, Seong-Su; Kwon, Eun-Young | Kyungpook Natl Univ, Dept Food Sci & Nutr, Daegu 41566, South Korea; Kyungpook Natl Univ, Ctr Food & Nutr Genom, Daegu 41566, South Korea; Kyungpook Natl Univ, Ctr Beautiful Aging, Daegu 41566, South Korea | ; Choi, Seongsu/LXA-4405-2024 | 57191253762; 23988149900; 58631087000; 59471125100; 15765422500 | baehee@knu.ac.kr;eykwon@knu.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 23 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 0 | 2025-05-07 | 0 | 0 | neuroinflammation; obesity; systemic chronic inflammation; mitochondrial complex I activity; interferon-gamma | COMPLEX-I; MITOCHONDRIAL; INFLAMMATION; STRESS | interferon-gamma; mitochondrial complex I activity; neuroinflammation; obesity; systemic chronic inflammation | Adipose Tissue; Alzheimer Disease; Animals; Biomarkers; Brain; Diet, High-Fat; Disease Models, Animal; Electron Transport Complex I; Humans; Inflammation; Interferon-gamma; Liver; Male; Mice; Mice, Inbred C57BL; Neuroinflammatory Diseases; Obesity; amyloid beta protein; biological marker; gamma interferon; gamma1b interferon; insulin receptor; interleukin 6; reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone); RNA; tumor necrosis factor; ubiquinone; biological marker; gamma interferon; reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone); adipocyte; adipose tissue; aging; Alzheimer disease; animal experiment; animal model; animal tissue; Article; brain; brain region; brain tissue; C57BL mouse; chronic inflammation; controlled study; correlation analysis; degenerative disease; differential gene expression; DNA microarray; electron transport; entorhinal cortex; frontal cortex; gene; gene expression; gene expression profiling; gene set analysis; gene set enrichment analysis; gray matter; hippocampus; inflammation; insulin signaling; KEGG; lipid diet; liver; male; microarray analysis; mitochondrial gene; mouse; muscle; muscle tissue; nervous system inflammation; nonhuman; obesity; overlapping gene; oxidative phosphorylation; signal transduction; soleus muscle; temporal cortex; white adipose tissue; adverse event; animal; C57BL mouse; disease model; etiology; genetics; human; metabolism; obesity; pathology | English | 2024 | 2024-12 | 10.3390/ijms252312834 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Comprehensive Transcriptomic Analysis Reveals Cell-Type-Specific Roles of Human Odorant Receptors in Glioblastoma and the Tumor Microenvironment | Odorant receptors (ORs), which constitute approximately 50% of all human G protein-coupled receptors, are increasingly recognized for their diverse roles beyond odor perception, including functions in various pathological conditions like brain diseases and cancers. However, the roles of ORs in glioblastoma (GBM), the most aggressive primary brain tumor with a median survival of only 15 months, remain largely unexplored. Here, we performed an integrated transcriptomic analysis combining The Cancer Genome Atlas RNA-seq and single-cell RNA sequencing data from GBM patients to uncover cell-type-specific roles of ORs within the tumor and its microenvironment. Our findings reveal that ORs display distinct expression patterns, with OR51E1 enriched in pericytes linked to vascular remodeling and angiogenesis, OR2B11 associated with tumor-associated macrophages supporting immunosuppressive phenotypes, and OR2L13 correlated with synaptic activity in recurrent tumors, potentially mediating treatment-induced neuronal adaptations. These results highlight ORs as potential therapeutic targets, offering new insights into their regulatory roles in GBM progression, immune modulation, and treatment resistance. | Cho, Hee Jin; Yeo, Dong Jun; Yang, Heewoong; Koo, Jaehyung | Kyungpook Natl Univ, Adv Inst Sci & Technol, Dept Biomed Convergence Sci & Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu 41944, South Korea; Daegu Gyeongbuk Inst Sci & Technol DGIST, Dept New Biol, Daegu 42988, South Korea; Korea Brain Res Inst KBRI, Daegu 41062, South Korea | Koo, JaeHyung/R-3036-2019 | 55937716400; 59490050800; 59488564500; 8610443800 | heejincho@knu.ac.kr;iamydj0928@naver.com;yanghw@dgist.ac.kr;jkoo001@dgist.ac.kr; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 24 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 0 | 2025-05-07 | 0 | 0 | glioblastoma (GBM); odorant receptors (ORs); G protein-coupled receptors (GPCRs); tumor microenvironment (TME); single-cell RNA sequencing; vascular remodeling; angiogenesis; tumor-associated macrophages (TAMs); synaptic adaptation; therapeutic targets | OLFACTORY RECEPTORS; GENOMIC ANALYSIS; GLIOMA GROWTH; PROTEIN; GENE; SUBTYPES; 51E1 | angiogenesis; G protein-coupled receptors (GPCRs); glioblastoma (GBM); odorant receptors (ORs); single-cell RNA sequencing; synaptic adaptation; therapeutic targets; tumor microenvironment (TME); tumor-associated macrophages (TAMs); vascular remodeling | Brain Neoplasms; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Receptors, Odorant; Transcriptome; Tumor Microenvironment; Tumor-Associated Macrophages; G protein coupled receptor; RNA; temozolomide; transcriptome; adaptation; angiogenesis; animal experiment; Article; brain cortex; brain tumor; cancer survival; cell specificity; cohort analysis; controlled study; correlation analysis; differential expression analysis; gene expression; gene ontology; glioblastoma; human; human cell; human tissue; immunomodulation; immunosuppressive treatment; Kaplan Meier method; male; median survival time; nonhuman; olfactory receptor; pathogenesis; pathway enrichment analysis; pericyte; phenotype; principal component analysis; RNA sequence; RNA sequencing; single cell RNA seq; survival analysis; transcriptomics; tumor microenvironment; tumor-associated macrophage; vascular remodeling; brain tumor; gene expression profiling; gene expression regulation; genetics; glioblastoma; immunology; metabolism; pathology; tumor-associated macrophage | English | 2024 | 2024-12 | 10.3390/ijms252413382 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Controlled Molecular Arrangement of Cinnamic Acid in Layered Double Hydroxide through pi-pi Interaction for Controlled Release | Cinnamic acid (CA) was successfully incorporated into Zn-Al layered double hydroxide (LDH) through coprecipitation. The CA moiety was stabilized in the interlayer space through not only electrostatic interaction but also intermolecular pi-pi interaction. It was noteworthy that the CA arrangement was fairly independent of the charge density of LDH, showing the important role of the layer-CA and CA-CA interactions in molecular stabilization. Computer simulations using the Monte Carlo method as well as analytical approaches including infrared, UV-vis spectroscopy, and differential scanning calorimetry showed the existence of intermolecular interaction. In order to reinforce molecular stabilization, a neutral derivative of CA, cinnamaldehyde (CAD), was additionally incorporated into LDH. It was clearly shown that CAD played a role as a pi-pi interaction mediator to enhance the stabilization of CA. The time-dependent release of CA from LDH was first governed by the layer charge density of LDH; however, the existence of CAD provided additional stabilization to the CA arrangement to slow down the release kinetics. | Kim, Taeho; Paek, Seung-Min; Wang, Kang-Kyun; Park, Jin Kuen; Salles, Fabrice; Oh, Jae-Min | Dongguk Univ, Dept Energy & Mat Engn, Seoul 04620, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; BI Biophoton Co Ltd, Gimpo 10090, South Korea; Hankuk Univ Foreign Studies, Dept Chem, Yongin 17035, South Korea; Univ Montpellier, Inst Charles Gerhardt ICGM, ENSCM, CNRS, F-34090 Montpellier, France | ; Paek, Seung-Min/E-4667-2011; SALLES, Fabrice/G-3881-2017 | 58488443800; 7102686289; 35254306000; 55085701500; 25222029000; 7402155053 | taeho0408@naver.com;biprimelab2020@gmail.com;jinkpark@hufs.ac.kr;fabrice.salles@umontpellier.fr;jaemin.oh@dongguk.edu; | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | INT J MOL SCI | 1661-6596 | 1422-0067 | 25 | 8 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.9 | 22.4 | 0 | 2025-05-07 | 0 | 0 | layered double hydroxide; molecular arrangement; phenolic acid; cinnamic acid; pi-pi interaction; release; intermolecular interaction | INTERCALATION; BEHAVIOR; DRUGS | cinnamic acid; intermolecular interaction; layered double hydroxide; molecular arrangement; phenolic acid; release; π-π interaction | Acrolein; Calorimetry, Differential Scanning; Cinnamates; Delayed-Action Preparations; Hydroxides; Kinetics; Monte Carlo Method; aluminum; carbonic acid; cinnamaldehyde; cinnamic acid; ferulic acid; gallic acid; hydroxide; nitrate; vanillic acid; zinc; acrolein; cinnamic acid; cinnamic acid derivative; adsorption; Article; atmosphere; chemical bond; computer simulation; controlled study; density; differential scanning calorimetry; enthalpy; Fourier transform infrared spectroscopy; high performance liquid chromatography; molecule; Monte Carlo method; scanning electron microscopy; static electricity; timed drug release; ultraviolet visible spectroscopy; X ray diffraction; chemistry; delayed release formulation; kinetics | English | 2024 | 2024-04 | 10.3390/ijms25084506 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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