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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Verification of the Necessity of the Tolyl Group of PF-543 for Sphingosine Kinase 1 Inhibitory Activity | PF-543, the most potent sphingosine kinase (SK) inhibitor, does not demonstrate effective anticancer activity in some cancer cells, unlike other known SK1 inhibitors. PF-543 has a non-lipid structure with a unique toluene backbone; however, the importance of this structure remains unclear. Therefore, the purpose of this study was to investigate changes in SK inhibitory and anticancer activities and to explore the role of the tolyl group structure of PF-543 through various modifications. We transformed the methyl group of PF-543 into hydrogen, fluorine, and hydroxy. PF-543 derivatives in which the methyl group was substituted by hydrogen and fluorine (compound 5) demonstrated SK1 inhibitory and anticancer activities similar to PF-543. Moreover, we performed molecular modeling studies of PF-543 and compound 5. To assess the metabolic stability of PF-543 and compound 5, we determined their degree of degradation using the liver microsomes of four different animal species (human, dog, rat, and mouse). However, both PF-543 and compound 5 showed poor microsomal stability. Therefore, for the medical applications of PF-543, the structural modifications of its other parts may be necessary. Our results provide important information for the design of additional PF-543 analogs. | Kim, Su Bin; Lee, Taeho; Moon, Hong Seop; Ki, Sung Hwan; Oh, Yoon Sin; Lee, Joo-Youn; Kim, Sang-Bum; Park, Jeong-Eun; Kwon, Yongseok; Kim, Sanghee; Baek, Dong Jae; Park, Eun-Young | Mokpo Natl Univ, Coll Pharm, Jeonnam 58554, South Korea; Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Chosun Univ, Coll Pharm, Gwangju 61452, South Korea; Eulji Univ, Dept Food & Nutr, Seongnam 13135, South Korea; Korea Res Inst Chem Technol, Chem Data Driven Res Ctr, 141 Gajeong Ro, Daejeon 34114, South Korea; Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, 80 Cheombok Ro, Daegu 41061, South Korea; Sogang Univ, Dept Chem, Seoul 04107, South Korea; Seoul Natl Univ, Coll Pharm, Seoul 08826, South Korea | ; Kwon, Yongseok/KDN-3914-2024 | 57217012276; 57204032003; 55826455800; 8346836500; 34467778200; 57216486264; 57196231559; 57217012438; 50262209500; 57188626570; 57200593717; 56680548000 | rlatnqls0801@naver.com;tlee@knu.ac.kr;hbsmoon@mokpo.ac.kr;shki@chosun.ac.kr;ysoh@eulji.ac.kr;leejooyoun@snu.ac.kr;ksb2014@dgmif.re.kr;parkje6605@dgmif.re.kr;ykwon@sogang.ac.kr;pennkim@snu.ac.kr;dbaek@mokpo.ac.kr;parkey@mokpo.ac.kr; | MOLECULES | MOLECULES | 1420-3049 | 25 | 11 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 4.412 | 35.1 | 0.49 | 2025-06-25 | 5 | 7 | sphingosine kinase; PF-543; BODIPY; anticancer; inhibitor; derivative | CANCER; METABOLISM; FTY720; POTENT | Anticancer; BODIPY; Derivative; Inhibitor; PF-543; Sphingosine kinase | Animals; Boron Compounds; Dogs; Humans; Methanol; Mice; Microsomes, Liver; Phosphotransferases (Alcohol Group Acceptor); Pyrrolidines; Rats; Structure-Activity Relationship; Sulfones; 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; boron derivative; methanol; PF-543; phosphotransferase; pyrrolidine derivative; sphingosine kinase; sulfone; animal; chemistry; dog; drug effect; human; liver microsome; metabolism; mouse; rat; structure activity relation | English | 2020 | 2020-06 | 10.3390/molecules25112484 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | An immersed boundary formulation incorporating a two-layer wall model approach for RANS simulations with complex geometry | We propose an immersed boundary (IB) formulation incorporating a two-layer wall model approach for Reynolds-averaged Navier-Stokes (RANS) simulations with complex geometry. The main objective of the present study is to broaden the capability of the IB method to high-Reynolds number turbulent flows with non-equilibrium effects. A two-layer wall model is applied to the IB method by considering a thin boundary layer approximation near the wall in order to reduce the computational cost of resolving the turbulent boundary layer. Tangential pressure gradient and convective terms are included in the thin boundary layer equation to make the wall model suitable for non-equilibrium flows, in which cross-derivative terms are modeled along the wall-normal direction to maintain the ordinary differential form of the equation. Turbulent viscosity in the inner layer is determined using a simplified k - epsilon - f(mu) model, that performs better than the typical mixing-length model in the separation and reattachment regions, where the friction velocity u(tau) becomes zero. To impose the mass conservation constraint near the IB surface with marginal computational cost, the IB approximated domain method is applied. The proposed IB formulation is validated using numerical simulations of two-dimensional turbulent channel flow, backward-facing step flow, turbulent flow around a circular cylinder, and three-dimensional turbulent flow over a wall-mounted circular sphere with a relatively coarse grid near the IB surface. The results demonstrate that the proposed IB formulation captures the flow patterns well and accurately predicts wall shear stress for both equilibrium and non-equilibrium flows, even with a relatively coarse grid near the wall. (C) 2020 Elsevier Ltd. All rights reserved. | Park, Hyunwook; Oh, Geunwoo; Park, Tae Seon; Lee, Changhoon; Choi, Jung-Il | Yonsei Univ, Dept Computat Sci & Engn, Seoul 03722, South Korea; Yonsei Univ, Dept Mech Engn, Seoul 03722, South Korea; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; HANKOOK TIRE Co Ltd, R&D Staff Off, 50 Yuseong Daero,935 Beon Gil, Daejeon 34127, South Korea | Choi, Jung-Il/AHD-5660-2022; Choi, Jung-Il/A-4086-2008; Lee, Changhoon/D-1596-2013 | 57188678721; 57201665737; 7401801892; 7410152282; 55800746400 | deukgyun@naver.com;genugenu@naver.com;tsparkjp@knu.ac.kr;clee@yonsei.ac.kr;jic@yonsei.ac.kr; | COMPUTERS & FLUIDS | COMPUT FLUIDS | 0045-7930 | 1879-0747 | 205 | SCIE | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS;MECHANICS | 2020 | 3.013 | 35.2 | 0.29 | 2025-06-25 | 4 | 5 | Immersed boundary method; Reynolds-averaged Navier-Stokes equations; Two-layer wall model; Non-equilibrium effect; Incompressible flows | LARGE-EDDY SIMULATION; NUMERICAL-SIMULATION; CIRCULAR-CYLINDER; TURBULENT-FLOW | Immersed boundary method; Incompressible flows; Non-equilibrium effect; Reynolds-averaged Navier-Stokes equations; Two-layer wall model | Boundary layer flow; Boundary layers; Channel flow; Circular cylinders; Navier Stokes equations; Reynolds number; Rhenium compounds; Shear flow; Shear stress; Turbulent flow; Backward-facing step flows; Flow around a circular cylinder; Non-equilibrium effects; Non-equilibrium flows; Reynolds-averaged navier-stokes simulations; Three-dimensional turbulent flow; Turbulent boundary layers; Turbulent channel flows; Atmospheric thermodynamics | English | 2020 | 2020-06-15 | 10.1016/j.compfluid.2020.104551 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Analysis of the Sensing Margin of Silicon and Poly-Si 1T-DRAM | Recently, one-transistor dynamic random-access memory (1T-DRAM) cells having a polysilicon body (poly-Si 1T-DRAM) have attracted attention as candidates to replace conventional one-transistor one-capacitor dynamic random-access memory (1T-1C DRAM). Poly-Si 1T-DRAM enables the cost-effective implementation of a silicon-on-insulator (SOI) structure and a three-dimensional (3D) stacked architecture for increasing integration density. However, studies on the transient characteristics of poly-Si 1T-DRAM are still lacking. In this paper, with TCAD simulation, we examine the differences between the memory mechanisms in poly-Si and silicon body 1T-DRAM. A silicon 1T-DRAM cell's data state is determined by the number of holes stored in a floating body (FB), while a poly-Si 1T-DRAM cell's state depends on the number of electrons trapped in its grain boundary (GB). This means that a poly-Si 1T-DRAM can perform memory operations by using GB as a storage region in thin body devices with a small FB area. | Kim, Hyeonjeong; Yoo, Songyi; Kang, In-Man; Cho, Seongjae; Sun, Wookyung; Shin, Hyungsoon | Ewha Womans Univ, Dept Elect & Elect Engn, Seoul 03760, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 702701, South Korea; Gachon Univ, Dept Elect Engn, Gyeonggi Do 461701, South Korea | shin, hyungsoon/I-1792-2016 | 57211265189; 57215561932; 7203062678; 13607031400; 7404011223; 7404012125 | laguswjd95@naver.com;dbthdd10219@ewhain.net;imkang@ee.knu.ac.kr;felixcho@gachon.ac.kr;wkyungsun@ewha.ac.kr;hsshin@ewha.ac.kr; | MICROMACHINES | MICROMACHINES-BASEL | 2072-666X | 11 | 2 | SCIE | CHEMISTRY, ANALYTICAL;INSTRUMENTS & INSTRUMENTATION;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2020 | 2.891 | 35.2 | 0.76 | 2025-06-25 | 9 | 10 | one-transistor dynamic random-access memory (1T-DRAM); polysilicon; grain boundary; electron trapping | 1T DRAM CELL; CAPACITORLESS 1T-DRAM; GRAIN-BOUNDARY; MOSFET | Electron trapping; Grain boundary; One-transistor dynamic random-access memory (1T-DRAM); Polysilicon | Cost effectiveness; Floating breakwaters; Grain boundaries; Polysilicon; Silicon on insulator technology; Cost-effective implementations; Dynamic random access memory; Electron trapping; Integration density; One-transistor dynamic random access memory (1t-dram); Silicon on insulator structures; Threedimensional (3-d); Transient characteristic; Dynamic random access storage | English | 2020 | 2020-02 | 10.3390/mi11020228 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Continuous Determination of Glucose Using a Membraneless, Microfluidic Enzymatic Biofuel Cell | In this article, we describe an enzyme-based, membraneless, microfluidic biofuel cell for the continuous determination of glucose using electrochemical power generation as a transducing signal. Enzymes were immobilized on multi-walled carbon nanotube (MWCNT) electrodes placed parallel to the co-laminar flow in a Y-shaped microchannel. The microchannel was produced with polydimethylsiloxane (PDMS) using soft lithography, while the MWCNT electrodes were replicated via a PDMS stencil on indium tin oxide (ITO) glass. Moreover, the electrodes were modified with glucose oxidase and laccase by direct covalent bonding. The device was studied at different MWCNT deposition amounts and electrolyte flow rates to achieve optimum settings. The experimental results demonstrated that glucose could be determined linearly up to a concentration of 4 mM at a sensitivity of 31 mV center dot mM(-1)cm(-2). | Khan, Haroon; Choi, Jin Ho; Ullah, Asad; Kim, Young Ho; Kim, Gyu Man | Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Insung Med Co, Daegu Gyeongbuk Med Innovat Fdn, Daegu 41071, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Med Device Dev Ctr, Daegu 41061, South Korea | 14521310700; 56145661300; 57226132377; 57214047450; 55664733000 | mechy_365@yahoo.com;chlwlsgh01@gmail.com;sasadullah84@gmail.com;yhkim@dgmif.re.kr;gyuman.kim@knu.ac.kr; | MICROMACHINES | MICROMACHINES-BASEL | 2072-666X | 11 | 12 | SCIE | CHEMISTRY, ANALYTICAL;INSTRUMENTS & INSTRUMENTATION;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2020 | 2.891 | 35.2 | 0.69 | 2025-06-25 | 11 | 11 | continuous glucose determination; membraneless; enzymatic biofuel cell | BIOSENSORS; ELECTRODE; NANOPARTICLES; CONSTRUCTION; OXIDASE; CATHODE | Continuous glucose determination; Enzymatic biofuel cell; Membraneless | Biofuels; Electrodes; Electrolytes; Enzymatic fuel cells; Enzyme electrodes; Glucose; Glucose oxidase; Glucose sensors; ITO glass; Laminar flow; Microchannels; Microfluidics; Polydimethylsiloxane; Silicones; Tin oxides; Covalent bonding; Electrochemical power generation; Electrolyte flow rates; Indium tin oxide; Membraneless; Mwcnt electrodes; Polydimethylsiloxane PDMS; Soft lithography; Multiwalled carbon nanotubes (MWCN) | English | 2020 | 2020-12 | 10.3390/mi11121129 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Design and Analysis of Gallium Nitride-Based p-i-n Diode Structure for Betavoltaic Cell with Enhanced Output Power Density | In this work, Gallium Nitride (GaN)-based p-i-n diodes were designed using a computer aided design (TCAD) simulator for realizing a betavoltaic (BV) cell with a high output power density (P-out). The short-circuit current density (J(SC)) and open-circuit voltage (V-OC) of the 17 keV electron-beam (e-beam)-irradiated diode were evaluated with the variations of design parameters, such as the height and doping concentration of the intrinsic GaN region (Hi-GaN and Di-GaN), which influenced the depletion width in the i-GaN region. A high Hi-GaN and a low Di-GaN improved the P-out because of the enhancement of absorption and conversion efficiency. The device with the Hi-GaN of 700 nm and Di-GaN of 1 x 10(16) cm(-3) exhibited the highest P-out. In addition, the effects of native defects in the GaN material on the performances were investigated. While the reverse current characteristics were mainly unaffected by donor-like trap states like N vacancies, the Ga vacancies-induced acceptor-like traps significantly decreased the J(SC) and V-OC due to an increase in recombination rate. As a result, the device with a high acceptor-like trap density dramatically degenerated the P-out. Therefore, growth of the high quality i-GaN with low acceptor-like traps is important for an enhanced P-out in BV cell. | Yoon, Young Jun; Lee, Jae Sang; Kang, In Man; Lee, Jung Hee; Kim, Dong Seok | Korea Atom Energy Res Inst, Korea Multipurpose Accelerator Complex, Gyeongju 38180, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | 57218864885; 7601467686; 7203062678; 57196140713; 55642581500 | yjyoon@kaeri.re.kr;jslee8@kaeri.re.kr;imkang@ee.knu.ac.kr;jlee@ee.knu.ac.kr;dongseokkim@kaeri.re.kr; | MICROMACHINES | MICROMACHINES-BASEL | 2072-666X | 11 | 12 | SCIE | CHEMISTRY, ANALYTICAL;INSTRUMENTS & INSTRUMENTATION;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2020 | 2.891 | 35.2 | 0.15 | 2025-06-25 | 3 | 3 | betavoltaic cell; Gallium Nitride (GaN); high-output power; TCAD simulation | DEFECTS; MODEL | Betavoltaic cell; Gallium Nitride (GaN); High-output power; TCAD simulation | Computer aided design; Diodes; III-V semiconductors; Nitrides; Nuclear batteries; Open circuit voltage; Design and analysis; Design parameters; Doping concentration; Gallium nitrides (GaN); High output power; Output power density; P-i-n diode structures; Recombination rate; Gallium nitride | English | 2020 | 2020-12 | 10.3390/mi11121100 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Fabrication and Performance Evaluation of the Helmholtz Resonator Inspired Acoustic Absorber Using Various Materials | A soundwave is transmitted by adjacent molecules in the medium, and depending on the type of sound, it exhibits various characteristics such as frequency, sound pressure, etc. If the acoustic wavelength of the soundwave is sufficiently long compared with the size of an acoustic element, physical analysis within the sound element could be simplified regardless of the shape of the acoustic element: this is called "long wavelength approximation". A Helmholtz resonator, a representative acoustic element which satisfies the "long wavelength theory", consists of a neck part and a cavity part. The Helmholtz resonators can absorb certain frequencies of sound through resonance. To exhibit attenuation properties at ultrasound range, the Helmholtz resonator should be made into a microscale since Helmholtz resonators should satisfy the "long wavelength approximation". In this study, Helmholtz resonator inspired acoustic elements were fabricated using MEMS technology, and acoustic attenuation experiments in a water bath were conducted using various shapes and materials. As a result, the fabricated samples showed admirable attenuation properties up to similar to 13 dB mm(-1) at 1 MHz. The results were analyzed to derive the necessary conditions for the fabrication of acoustic elements with acoustic attenuation properties in ultrasound range. | Lee, Sung Ho; Kang, Bong Su; Kim, Gyu Man; Roh, Yong Rae; Kwak, Moon Kyu | Kyungpook Natl Univ, Dept Mech Engn, Daegu 41566, South Korea | ; Kwak, Moon/AGQ-6058-2022 | 56195582600; 55330925300; 55664733000; 7102361870; 57203947984 | lee_sh@knu.ac.kr;bong-su@knu.ac.kr;gyuman.kim@knu.ac.kr;yryong@knu.ac.kr;mkkwak@knu.ac.kr; | MICROMACHINES | MICROMACHINES-BASEL | 2072-666X | 11 | 11 | SCIE | CHEMISTRY, ANALYTICAL;INSTRUMENTS & INSTRUMENTATION;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2020 | 2.891 | 35.2 | 0.54 | 2025-06-25 | 12 | 10 | Helmholtz resonator; acoustic attenuation; photolithography; ultrasound; microscale | ROLL-TO-ROLL; DRY ADHESIVES; SURFACE | Acoustic attenuation; Helmholtz resonator; Microscale; Photolithography; Ultrasound | Acoustic variables control; Fabrication; Ultrasonics; Acoustic absorbers; Acoustic attenuation; Acoustic elements; Acoustic wavelength; Attenuation properties; Helmholtz resonators; Long-wavelength approximation; Physical analysis; Acoustic resonators | English | 2020 | 2020-11 | 10.3390/mi11110983 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Ferroelectric Switching in Trilayer Al2O3/HfZrOx/Al2O3 Structure | Since ferroelectricity has been observed in simple binary oxide material systems, it has attracted great interest in semiconductor research fields such as advanced logic transistors, non-volatile memories, and neuromorphic devices. The location in which the ferroelectric devices are implemented depends on the specific application, so the process constraints required for device fabrication may be different. In this study, we investigate the ferroelectric characteristics of Zr doped HfO2 layers treated at high temperatures. A single HfZrOx layer deposited by sputtering exhibits polarization switching after annealing at a temperature of 850 degrees C. However, the achieved ferroelectric properties are vulnerable to voltage stress and higher annealing temperature, resulting in switching instability. Therefore, we introduce an ultrathin 1-nm-thick Al2O3 layer at both interfaces of the HfZrOx. The trilayer Al2O3/HfZrOx/Al2O3 structure allows switching parameters such as remnant and saturation polarizations to be immune to sweeping voltage and pulse cycling. Our results reveal that the trilayer not only makes the ferroelectric phase involved in the switching free from pinning, but also preserves the phase even at high annealing temperature. Simultaneously, the ferroelectric switching can be improved by preventing leakage charge. | Im, Solyee; Kang, Seung-Youl; Kim, Yeriaron; Kim, Jeong Hun; Im, Jong-Pil; Yoon, Sung-Min; Moon, Seung Eon; Woo, Jiyong | Elect & Telecommun Res Inst, ICT Creat Res Lab, Daejeon 34129, South Korea; Kyung Hee Univ, Dept Adv Mat Engn Informat & Elect, Yongin 17104, Gyeonggi, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea | Yoon, Minjoong/B-1162-2008; Moon, Seung/AAQ-3181-2021; Kang, Seung-Youl/JDD-8544-2023 | 57218167297; 7405686721; 57207444978; 57194613724; 57204538127; 7404035863; 7401616067; 53985749100 | solyeeim@etri.re.kr;kang2476@etri.re.kr;yrar.kim@etri.re.kr;jeonghun@etri.re.kr;jpim@etri.re.kr;sungmin@khu.ac.kr;semoon@etri.re.kr;jiyong.woo@knu.ac.kr; | MICROMACHINES | MICROMACHINES-BASEL | 2072-666X | 11 | 10 | SCIE | CHEMISTRY, ANALYTICAL;INSTRUMENTS & INSTRUMENTATION;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2020 | 2.891 | 35.2 | 0.54 | 2025-06-25 | 10 | 9 | ferroelectric switching; HfZrOx; trilayer structure | THIN-FILMS; OXIDE | Ferroelectric switching; HfZrO<sub>x</sub>; Trilayer structure | Annealing; Data storage equipment; Hafnium oxides; Polarization; Semiconductor devices; Switching; Annealing temperatures; Ferroelectric characteristics; Ferroelectric phase; Ferroelectric property; Ferroelectric switching; Polarization switching; Saturation polarization; Switching parameters; Ferroelectricity | English | 2020 | 2020-10 | 10.3390/mi11100910 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Near-Infrared Organic Phototransistors with Polymeric Channel/Dielectric/Sensing Triple Layers | A new type of near-infrared (NIR)-sensing organic phototransistor (OPTR) was designed and fabricated by employing a channel/dielectric/sensing (CDS) triple layer structure. The CDS structures were prepared by inserting poly(methyl methacrylate) (PMMA) dielectric layers (DLs) between poly(3-hexylthiophene) (P3HT) channel layers and poly[{2,5-bis-(2-octyldodecyl)-3,6-bis-(thien-2-yl)-pyrrolo[3,4-c]pyrrole-1,4-diyl}-co-{2,2 '-(2,1,3-benzothiadiazole)-5,5 '-diyl}] (PODTPPD-BT) top sensing layers. Two different thicknesses of PMMA DLs (20 nm and 50 nm) were applied to understand the effect of DL thickness on the sensing performance of devices. Results showed that the NIR-OPTRs with the CDS structures were operated in a typical n-channel mode with a hole mobility of ca. 0.7 similar to 3.2 x 10(-4) cm(2)/Vs in the dark and delivered gradually increased photocurrents upon illumination with an NIR light (905 nm). As the NIR light intensity increased, the threshold voltage was noticeably shifted, and the resulting transfer curves showed a saturation tendency in terms of curve shape. The operation of the NIR-OPTRs with the CDS structures was explained by the sensing mechanism that the excitons generated in the PODTPPD-BT top sensing layers could induce charges (holes) in the P3HT channel layers via the PMMA DLs. The optically modulated and reflected NIR light could be successfully detected by the present NIR-OPTRs with the CDS structures. | Kim, Taehoon; Lee, Chulyeon; Kim, Youngkyoo | Kyungpook Natl Univ, Sch Appl Chem Engn, Dept Chem Engn, Organ Nanoelect Lab,KNU Inst Nanophoton Applicat, Daegu 41566, South Korea | 57218650958; 56354831300; 10340424400 | k2557497@hanmail.net;lcyyeon@naver.com;ykimm@knu.ac.kr; | MICROMACHINES | MICROMACHINES-BASEL | 2072-666X | 11 | 12 | SCIE | CHEMISTRY, ANALYTICAL;INSTRUMENTS & INSTRUMENTATION;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2020 | 2.891 | 35.2 | 0.38 | 2025-06-25 | 7 | 8 | near infrared; organic phototransistors; conjugated polymers; dielectric layers; photocurrent; threshold voltage; on/off modulation; LiDAR | FIELD-EFFECT TRANSISTORS; HYBRID MATERIALS; PHOTODETECTORS | Conjugated polymers; Dielectric layers; LiDAR; Near infrared; On/off modulation; Organic phototransistors; Photocurrent; Threshold voltage | Aromatic compounds; Esters; Field effect transistors; Hole mobility; Photocurrents; Phototransistors; Threshold voltage; 2 ,1 ,3-Benzothiadiazole; Dielectric layer; Organic phototransistors; Poly(methyl methacrylate) (PMMA); Poly-3-hexylthiophene; Sensing mechanism; Sensing performance; Triple-layer structures; Infrared devices | English | 2020 | 2020-12 | 10.3390/mi11121061 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Recent Advances of Fluid Manipulation Technologies in Microfluidic Paper-Based Analytical Devices (μPADs) toward Multi-Step Assays | Microfluidic paper-based analytical devices (mu PADs) have been suggested as alternatives for developing countries with suboptimal medical conditions because of their low diagnostic cost, high portability, and disposable characteristics. Recently, paper-based diagnostic devices enabling multi-step assays have been drawing attention, as they allow complicated tests, such as enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR), which were previously only conducted in the laboratory, to be performed on-site. In addition, user convenience and price of paper-based diagnostic devices are other competitive points over other point-of-care testing (POCT) devices, which are more critical in developing countries. Fluid manipulation technologies in paper play a key role in realizing multi-step assays via mu PADs, and the expansion of biochemical applications will provide developing countries with more medical benefits. Therefore, we herein aimed to investigate recent fluid manipulation technologies utilized in paper-based devices and to introduce various approaches adopting several principles to control fluids on papers. Fluid manipulation technologies are classified into passive and active methods. While passive valves are structurally simple and easy to fabricate, they are difficult to control in terms of flow at a specific spatiotemporal condition. On the contrary, active valves are more complicated and mostly require external systems, but they provide much freedom of fluid manipulation and programmable operation. Both technologies have been revolutionized in the way to compensate for their limitations, and their advances will lead to improved performance of mu PADs, increasing the level of healthcare around the world. | Kim, Taehoon H.; Hahn, Young Ki; Kim, Minseok S. | CytoDx, Seongnam Si 13486, South Korea; Kyungpook Natl Univ, Ind Technol Adv, Biomed Convergence Sci & Technol, 80 Daehakro, Bukgu 41566, Daegu, South Korea; DGIST, Dept New Biol, 333 Techno Jungang Daero, Daegu 42988, South Korea | Kim, Minseok/AAJ-4797-2020 | 59784575600; 16052846700; 57191998332 | thkim@cytodx.co.kr;hahnv79@gmail.com;kms@dgist.ac.kr; | MICROMACHINES | MICROMACHINES-BASEL | 2072-666X | 11 | 3 | SCIE | CHEMISTRY, ANALYTICAL;INSTRUMENTS & INSTRUMENTATION;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2020 | 2.891 | 35.2 | 2.52 | 2025-06-25 | 44 | 47 | microfluidic paper-based analytical devices (mu PADs); point-of-care testing; multi-step assay; fluid manipulation | QUANTITATIVE ELECTROCHEMICAL DETECTION; C-REACTIVE PROTEIN; 2-DIMENSIONAL PAPER; INSTRUMENT-FREE; LOW-COST; ELECTROPHORETIC SEPARATION; ISOTHERMAL AMPLIFICATION; SENSITIVE DETECTION; PATTERNED-PAPER; LABEL-FREE | Fluid manipulation; Microfluidic paper-based analytical devices (μPADs); Multi-step assay; Point-of-care testing | Analytic equipment; Developing countries; Diagnosis; Microfluidics; Polymerase chain reaction; Bio-chemical applications; Enzyme linked immunosorbent assay; Manipulation technologies; Medical conditions; Multi-step; Paper based devices; Paper-based analytical devices; Point-of-care testing; Paper | English | 2020 | 2020-03 | 10.3390/mi11030269 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Shrinkage-Considered Mold Design for Improvement of Micro/Nano-Structured Optical Element Performance | Polymer shrinkage in nano-imprint lithography (NIL) is one of the critical issues that must be considered in order to produce a quality product. Especially, this condition should be considered during the manufacture of optical elements, because micro/nano-structured optical elements should be controlled to fit the desired shape in order to achieve the intended optical performance. In this paper, during NIL, we characterized the shrinkage of polymeric resin on micro lens array (MLA), which is one of the representative micro/nano-structured optical elements. The curvature shape and optical performance of MLA were measured to check the shrinkage tendency during the process. The master mold of MLA was generated by the two-photon polymerization (2PP) additive manufacturing method, and the tested samples were replicated from the master mold with NIL. Several types of resin were adjusted to prepare the specimens, and the shrinkage effects in each case were compared. The shrinkage showed different trends based on the NIL materials and MLA shapes. These characterizations can be applied to compensate for the MLA design, and the desired performance of MLA products can be achieved with a corrected master mold. | Kim, Minsu; Oh, Eun Song; Kwak, Moon Kyu | Kyungpook Natl Univ, Dept Mech Engn, Daegu 41566, South Korea; YNG Inc, Pyeongtaek 17708, South Korea | Kwak, Moon/AGQ-6058-2022 | 57212315616; 57220700604; 57203947984 | kms1685@knu.ac.kr;esoh@yngoptics.com;mkkwak@knu.ac.kr; | MICROMACHINES | MICROMACHINES-BASEL | 2072-666X | 11 | 10 | SCIE | CHEMISTRY, ANALYTICAL;INSTRUMENTS & INSTRUMENTATION;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2020 | 2.891 | 35.2 | 0.31 | 2025-06-25 | 5 | 5 | micro-lens array (MLA); nano-imprint lithography (NIL); shrinkage; wafer-level optics (WLO) | NANOIMPRINT LITHOGRAPHY; IMPRINT LITHOGRAPHY; ROLL; STEP | Micro-lens array (MLA); Nano-imprint lithography (NIL); Shrinkage; Wafer-level optics (WLO) | 3D printers; Microlenses; Nanoimprint lithography; Product design; Resins; Shrinkage; Critical issues; Micro-lens arrays; Mold designs; Optical performance; Polymeric resin; Quality product; Shrinkage effects; Two photon polymerization; Molds | English | 2020 | 2020-10 | 10.3390/mi11100941 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Improvement of bioethanol production by Saccharomyces cerevisiae through the deletion of GLK1, MIG1 and MIG2 and overexpression of PGM2 using the red seaweed Gracilaria verrucosa | Gracilaria verrucosa can be used as a biomass source for bioethanol production with a high yield due to the high carbohydrate content. A monosaccharide concentration of 48.6 g/L was obtained from G. verrucosa using 0.2 M HNO3 at 150 degrees C for 10 min with a combined severity factor (R-o) of 0.47. The addition of Tween 20 with CTec2 increased the affinity of G. verrucosa slurry to the enzyme with a K-m value of 1.14 g/L compared with the K-m value of 1.82 g/L using CTec2 alone and reduced enzyme loading. To improve galactose consumption, the deletion of repressor genes including GLK1, MIG1, and MIG2 and the overexpression of PGM2 were investigated. The strain with the deletion of three repressor genes and overexpression of PGM2 produced 24.8 g/L ethanol (Y-EtOH = 0.46) and showed an enhanced galactose consumption rate (0.24 g/L/h) compared with the rate of the control strain (0.04 g/L/h). The deletion of three repressor genes and overexpression of PGM2 reduced the repression of GAL genes and increased the transcription level of GAL genes. However, the galactose consumption rate of this strain was lower than that of the strain adapted to a high concentration of galactose. | Sukwong, Pailin; Sunwoo, In Yung; Jeong, Deok Yeol; Kim, Soo Rin; Jeong, Gwi-Taek; Kim, Sung-Koo | Pukyong Natl Univ, Dept Biotechnol, Busan 48513, South Korea; Kyungpook Natl Univ, Dept Food Sci & Biotechnol, Daegu 37224, South Korea | Kim, Soo Rin/X-2192-2019; Jeong, Deokyeol/GLR-8021-2022 | 57195241085; 56506970700; 57191332457; 36659584200; 7102664797; 57195386876 | skkim@pknu.ac.kr; | PROCESS BIOCHEMISTRY | PROCESS BIOCHEM | 1359-5113 | 1873-3298 | 89 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY;ENGINEERING, CHEMICAL | 2020 | 3.757 | 35.3 | 0.8 | 2025-06-25 | 11 | 15 | Bioethanol production; Cas9; PGM2; Repressor genes; Saccharomyces cerevisiae | SINGLE KNOCKOUT STRAINS; ENZYMATIC-HYDROLYSIS; KAPPAPHYCUS-ALVAREZII; BIOMASS CONVERSION; GLUCOSE; YEAST; ACID; PHOSPHOGLUCOMUTASE; PRETREATMENT; STRATEGIES | Bioethanol production; Cas9; PGM2; Repressor genes; Saccharomyces cerevisiae | Enzymes; Ethanol; Strain rate; Transcription; Yeast; Bio-ethanol production; Carbohydrate content; Cas9; Combined severity factors; Consumption rates; Over-expression; PGM2; Transcription level; Bioethanol | English | 2020 | 2020-02 | 10.1016/j.procbio.2019.10.030 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Artificial intelligence that determines the clinical significance of capsule endoscopy images can increase the efficiency of reading | Artificial intelligence (AI), which has demonstrated outstanding achievements in image recognition, can be useful for the tedious capsule endoscopy (CE) reading. We aimed to develop a practical AI-based method that can identify various types of lesions and tried to evaluate the effectiveness of the method under clinical settings. A total of 203,244 CE images were collected from multiple centers selected considering the regional distribution. The AI based on the Inception-Resnet-V2 model was trained with images that were classified into two categories according to their clinical significance. The performance of AI was evaluated with a comparative test involving two groups of reviewers with different experiences. The AI summarized 67,008 (31.89%) images with a probability of more than 0.8 for containing lesions in 210,100 frames of 20 selected CE videos. Using the AI-assisted reading model, reviewers in both the groups exhibited increased lesion detection rates compared to those achieved using the conventional reading model (experts; 34.3%-73.0%; p = 0.029, trainees; 24.7%-53.1%; p = 0.029). The improved result for trainees was comparable to that for the experts (p = 0.057). Further, the AI-assisted reading model significantly shortened the reading time for trainees (1621.0-746.8 min; p = 0.029). Thus, we have developed an AI-assisted reading model that can detect various lesions and can successfully summarize CE images according to clinical significance. The assistance rendered by AI can increase the lesion detection rates of reviewers. Especially, trainees could improve their efficiency of reading as a result of reduced reading time using the AI-assisted model. | Park, Junseok; Hwang, Youngbae; Nam, Ji Hyung; Oh, Dong Jun; Kim, Ki Bae; Song, Hyun Joo; Kim, Su Hwan; Kang, Sun Hyung; Jung, Min Kyu; Jeong Lim, Yun | Soonchunhyang Univ, Coll Med, Inst Digest Res, Dept Internal Med,Digest Dis Ctr, Seoul, South Korea; Chungbuk Natl Univ, Dept Elect Engn, Cheongju, South Korea; Dongguk Univ, Coll Med, Ilsan Hosp, Div Gastroenterol,Dept Internal Med, Goyang, South Korea; Chungbuk Natl Univ, Coll Med, Dept Internal Med, Cheongju, South Korea; Jeju Natl Univ, Dept Internal Med, Sch Med, Jeju, South Korea; Seoul Metropolitan Govt Seoul Natl Univ, Boramae Med Ctr, Dept Internal Med, Seoul, South Korea; Chungnam Natl Univ, Div Gastroenterol & Hepatol, Dept Internal Med, Sch Med, Daejeon, South Korea; Kyungpook Natl Univ Hosp, Div Gastroenterol & Hepatol, Dept Internal Med, Daegu, South Korea | ; KIM, SUHWAN/GSE-0120-2022; Kim, Ki Bae/KYQ-0127-2024; Song, hyunjoo/GWC-1292-2022; Park, Junseok/ABS-0095-2022 | 57201131480; 7402311392; 42361607200; 57203029221; 56106965700; 57217466923; 57200822702; 57210973833; 56783168100; 56501161800 | drlimyj@gmail.com; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 10 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.77 | 2025-06-25 | 22 | 24 | Artificial Intelligence; Capsule Endoscopy; Humans; Image Processing, Computer-Assisted; Time Factors; article; artificial intelligence; capsule endoscopy; clinical article; comparative effectiveness; controlled study; human; multicenter study; probability; videorecording; image processing; procedures; time factor | English | 2020 | 2020-10-29 | 10.1371/journal.pone.0241474 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Association between proton pump inhibitor use and risk of fracture: A population-based case-control study | Objectives The purpose of this study was to reconfirm the association between the risk of fracture and proton pump inhibitor use and to establish evidence for defining a high-risk group of patients among proton pump inhibitor users. Methods A nested case-control study was performed using data from the National Health Insurance Sharing Service database from the period January 2007 to December 2017. The study population included elderly women aged >= 65 years with claims for peptic ulcer or gastro-esophageal reflux disease. The cases were all incidental osteoporotic fractures, and up to two controls were matched to each case by age, osteoporosis, and Charlson comorbidity index. Conditional logistic regression was used to calculate the adjusted odds ratio and 95% confidence interval (CI). Results A total of 21,754 cases were identified, and 43,508 controls were matched to the cases. The adjusted odds ratio of osteoporotic fractures related to the use of proton pump inhibitors was 1.15 (95% CI: 1.11-1.20). There was a statistically significant interaction between proton pump inhibitor and bisphosphonate use (p<0.01). The risk of fracture in patients using proton pump inhibitors was 1.15 (95% CI: 1.08-1.92) in bisphosphonate users and 1.11 (95% CI: 1.03-1.20) in bisphosphonate non-users. Conclusion Concomitant use of bisphosphonates and proton pump inhibitors will likely increase the risk of osteoporotic fractures in women aged 65 and over, and caution should be exercised in this high-risk group of patients. | Kim, Jong Joo; Jang, Eun Jin; Park, Jiwon; Sohn, Hyun Soon | Cha Univ, Pharmaceut Informat Res Inst, Gyeonggi Do, South Korea; Andong Natl Univ, Coll Nat Sci, Gyeongsangbuk Do, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Daegu Si, South Korea; Cha Univ, Coll Pharm, Gyeonggi Do, South Korea | 57217253710; 37861741600; 57188683828; 57202638453 | sohn64@cha.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 7 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.45 | 2025-06-25 | 12 | 14 | BONE-MINERAL DENSITY; HIP FRACTURE; THERAPY; BISPHOSPHONATES; COMBINATION; RESORPTION | Age Factors; Aged; Aged, 80 and over; Case-Control Studies; Diphosphonates; Drug Interactions; Female; Gastroesophageal Reflux; Humans; Middle Aged; Odds Ratio; Osteoporotic Fractures; Peptic Ulcer; Proton Pump Inhibitors; Republic of Korea; Risk Factors; bisphosphonic acid derivative; dexlansoprazole; esomeprazole; ilaprazole; lansoprazole; omeprazole; pantoprazole; proton pump inhibitor; rabeprazole; bisphosphonic acid derivative; proton pump inhibitor; aged; Article; case control study; Charlson Comorbidity Index; controlled study; disease association; drug exposure; drug use; female; fragility fracture; gastroesophageal reflux; high risk population; human; major clinical study; observational study; osteoporosis; peptic ulcer; risk factor; urban area; age; drug interaction; fragility fracture; middle aged; odds ratio; risk factor; South Korea; very elderly | English | 2020 | 2020-07-30 | 10.1371/journal.pone.0235163 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Behavior change due to COVID-19 among dental academics-The theory of planned behavior: Stresses, worries, training, and pandemic severity | Objective COVID-19 pandemic led to major life changes. We assessed the psychological impact of COVID-19 on dental academics globally and on changes in their behaviors. Methods We invited dental academics to complete a cross-sectional, online survey from March to May 2020. The survey was based on the Theory of Planned Behavior (TPB). The survey collected data on participants' stress levels (using the Impact of Event Scale), attitude (fears, and worries because of COVID-19 extracted by Principal Component Analysis (PCA), perceived control (resulting from training on public health emergencies), norms (country-level COVID-19 fatality rate), and personal and professional backgrounds. We used multilevel regression models to assess the association between the study outcome variables (frequent handwashing and avoidance of crowded places) and explanatory variables (stress, attitude, perceived control and norms). Results 1862 academics from 28 countries participated in the survey (response rate = 11.3%). Of those, 53.4% were female, 32.9% were <46 years old and 9.9% had severe stress. PCA extracted three main factors: fear of infection, worries because of professional responsibilities, and worries because of restricted mobility. These factors had significant dose-dependent association with stress and were significantly associated with more frequent handwashing by dental academics (B = 0.56, 0.33, and 0.34) and avoiding crowded places (B = 0.55, 0.30, and 0.28). Low country fatality rates were significantly associated with more handwashing (B = -2.82) and avoiding crowded places (B = -6.61). Training on public health emergencies was not significantly associated with behavior change (B = -0.01 and -0.11). Conclusions COVID-19 had a considerable psychological impact on dental academics. There was a direct, dose-dependent association between change in behaviors and worries but no association between these changes and training on public health emergencies. More change in behaviors was associated with lower country COVID-19 fatality rates. Fears and stresses were associated with greater adoption of preventive measures against the pandemic. | Ammar, Nour; Aly, Nourhan M.; Folayan, Morenike O.; Khader, Yousef; Virtanen, Jorma, I; Al-Batayneh, Ola B.; Mohebbi, Simin Z.; Attia, Sameh; Howaldt, Hans-Peter; Boettger, Sebastian; Maharani, Diah A.; Rahardjo, Anton; Khan, Imran; Madi, Marwa; Rashwan, Maher; Pavlic, Verica; Cicmil, Smiljka; Choi, Youn-Hee; Joury, Easter; Castillo, Jorge L.; Noritake, Kanako; Shamala, Anas; Galluccio, Gabriella; Polimeni, Antonella; Phantumvanit, Prathip; Mancino, Davide; Kim, Jin-Bom; Abdelsalam, Maha M.; Arheiam, Arheiam; Dama, Mai A.; Nyan, Myat; Hussein, Iyad; Alkeshan, Mohammad M.; Vukovic, Ana P.; Iandolo, Alfredo; Kemoli, Arthur M.; El Tantawi, Maha | Alexandria Univ, Fac Dent, Dept Pediat Dent & Dent Publ Hlth, Alexandria, Egypt; Obafemi Awolowo Univ, Dept Child Dent Hlth, Ife, Nigeria; Jordan Univ Sci & Technol, Dept Publ Hlth, Irbid, Jordan; Univ Bergen, Fac Med, Dept Clin Dent, Bergen, Norway; Jordan Univ Sci & Technol, Fac Dent, Dept Prevent Dent, Irbid, Jordan; Univ Tehran Med Sci, Res Ctr Caries Prevent, Dent Res Inst, Tehran, Iran; Univ Tehran Med Sci, Sch Dent, Community Oral Hlth Dept, Tehran, Iran; Justus Liebig Univ Giessen, Dept Craniomaxillofacial Surg, Giessen, Germany; Univ Indonesia, Fac Dent, Dept Prevent & Publ Hlth Dent, Depok, Indonesia; Jamia Millia Islamia, Dept Oral & Maxillofacial Surg, Fac Dent, New Delhi, India; Imam Abdulrahman Bin Faisal Univ, Coll Dent, Dept Prevent Dent Sci, Dammam, Saudi Arabia; Queen Mary Univ London, Ctr Oral Bioengn, Sch Med & Dent, Barts & London, London, England; Alexandria Univ, Fac Dent, Dept Conservat Dent, Alexandria, Egypt; Univ Banja Luka, Dept Periodontol & Oral Med, Med Fac, Banja Luka, Bosnia & Herceg; Univ East Sarajevo, Fac Med Foca, Dept Oral Rehabil, Foca, Bosnia & Herceg; Kyungpook Natl Univ, Sch Dent, Dept Prevent Dent, Daegu, South Korea; Queen Mary Univ London, Ctr Dent Publ Hlth & Primary Care, Barts & London Sch Med & Dent, Inst Dent, London, England; Univ Peruana Cayetano Heredia, Dept Dent Children & Adolescents, Lima, Peru; Tokyo Med & Dent Univ, Dent Hosp, Oral Diag & Gen Dent Dept, Tokyo, Japan; Univ Sci & Technol, Fac Dent, Dept Prevent & Biomed Sci, Sanaa, Yemen; Sapienza Univ Rome, Fac Med & Dent, Dept Oral & Maxillo Facial Sci, Rome, Italy; Thammasat Univ, Fac Dent, Bangkok, Thailand; Univ Strasbourg, Fac Dent Med, Dept Endodont & Conservat Dent, Strasbourg, France; Strasbourg Univ, Dept Biomat & Bioengn, INSERM, UMR S 1121, Strasbourg, France; Pusan Natl Univ, Sch Dent, Dept Prevent & Community Dent, Busan, South Korea; Imam Abdulrahman Bin Faisal Univ, Coll Dent, Dept Biomed Dent Sci, Dammam, Saudi Arabia; Univ Benghazi, Fac Dent, Dept Community & Prevent Dent, Benghazi, Libya; Arab Amer Univ, Fac Dent, Orthodont & Pediat Dent Dept, Jenin, Palestine; Univ Dent Med, Dept Prosthodont, Mandalay, Myanmar; Mohammed Bin Rashid Univ Med & Hlth Sci, Dept Pediat Dent, Dubai, U Arab Emirates; Seoul Natl Univ, Dept Pediat Dent, Dent Hosp, Seoul, South Korea; Univ Belgrade, Sch Dent Med, Dept Pediat & Prevent Dent, Belgrade, Serbia; Univ Salerno, Dept Endodont, Fisciano, Italy; Univ Nairobi, Sch Dent Sci, Dept Paediat Dent & Orthodont, Nairobi, Kenya | Vukovic, Ana/AAN-8526-2021; Nyan, Myat/ABC-2189-2021; Joury, Easter/KLY-4825-2024; Mohebbi, Simin/L-8864-2018; Khader, Yousef/AAE-9620-2019; Maharani, Diah/AAI-1630-2020; Mancino, Davide/AEZ-6159-2022; Cicmil, Smiljka/ABF-6588-2020; El Tantawi, Maha/K-4336-2014; Folayan, Morenike/A-8632-2018; Rashwan, Maher/GOE-6992-2022; Iandolo, Alfredo/ABD-9371-2021; Aly, Nourhan/AAA-8899-2020; Folayan, Morenike Oluwatoyin/A-8632-2018; Attia, Sameh/Z-4369-2019; Madi, Marwa/AAE-5694-2019; Ammar, Nour/AAV-7367-2021; Khan, Imran/ABB-2311-2020; arheiam, arheiam/H-9217-2019; Hussein, Iyad/L-9254-2019; Böttger, Sebastian/AAB-3864-2022; Kemoli, Arthur/D-4494-2015; Al-Batayneh, Ola/AAF-2338-2019; khader, yousef/AAE-9620-2019; PAVLIC, Verica/Y-7351-2018; Shamala, Anas/GQA-6717-2022; GALLUCCIO, Gabriella/AAR-7459-2020; Virtanen, Jorma/AAP-1160-2021; El Tantawi, Maha/IAN-4212-2023; Kim, Jin-Bom/Z-2061-2019; Rahardjo, Anton/KMX-3559-2024 | 57219318092; 57204047005; 56725310700; 55654192600; 57190000344; 36164877800; 15755676200; 57191255716; 7003956751; 7005537084; 32867911000; 8952045300; 56277375500; 55192213300; 57205750301; 55328457700; 36571350800; 7404777239; 38861666700; 7202601901; 57191265748; 57194494767; 58128457700; 55018305300; 6603684618; 57200247725; 26662581900; 56606899600; 56030206800; 57203821523; 21233951800; 19535106900; 57219311764; 57189182795; 55185027200; 14035790900; 57214851491 | maha_tantawy@hotmail.com; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 9 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 3.12 | 2025-06-25 | 77 | 76 | Adult; Aged; Betacoronavirus; Coronavirus Infections; Cross-Sectional Studies; Faculty, Dental; Female; Hand Disinfection; Health Behavior; Humans; Male; Middle Aged; Occupational Stress; Pandemics; Pneumonia, Viral; Principal Component Analysis; Psychological Theory; Surveys and Questionnaires; adult; aged; Article; attitude; avoidance behavior; behavior change; controlled study; coronavirus disease 2019; cross-sectional study; crowding (area); dental academics; dentistry; emergency; fear; female; hand washing; human; male; mortality rate; online system; pandemic; patient worry; principal component analysis; public health; questionnaire; responsibility; social norm; stress; Theory of Planned Behavior; training; Betacoronavirus; Coronavirus infection; dental education; epidemiology; hand disinfection; health behavior; job stress; middle aged; pandemic; psychological theory; psychology; virus pneumonia | English | 2020 | 2020-09-29 | 10.1371/journal.pone.0239961 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Changes and prognostic values of tumor-infiltrating lymphocyte subsets after primary systemic therapy in breast cancer | Tumor-infiltrating lymphocyte (TIL) levels have prognostic and predictive values in treatment-naive breast cancers. However, there have been controversies regarding TIL subset changes and their clinical implications in post-treatment breast cancers. This study aimed to explore change and prognostic significance of TIL subset infiltration after primary systemic therapy (PST) in breast cancer. One-hundred-fifty-five patients who had residual disease after anthracycline- or anthracycline plus taxane-based PST were included. The quantities of intratumoral and stromal TIL subsets (CD8+, CD4+, and FOXP3+ TILs) in pre- and post-PST breast cancer samples, as well as changes between them, were analyzed along with their correlations with clinicopathologic features and outcome of patients. As a whole, intratumoral CD8+ and CD4+ TILs increased after PST while stromal TILs decreased. Both intratumoral and stromal FOXP3+ TILs decreased after PST. The chemo-sensitive group [residual cancer burden (RCB) class I and II] showed the same pattern of change in intratumoral CD8+ TILs as the whole group, whereas the chemo-resistant group (RCB class III) showed no significant change in intratumoral CD8+ TIL infiltration after PST. Survival analyses for each TIL subset as well as their ratios revealed that high levels of intratumoral, stromal, and total CD8+ TIL infiltration after PST were independent predictors of longer patient survival. In subgroup analyses, CD8+ TIL infiltration after PST revealed prognostic significance in the chemo-resistant group but not in the chemo-sensitive group. In conclusion, infiltration of CD8+, CD4+, and FOXP3+ TIL changed after PST in the intratumoral and stromal compartments. Especially, increase of intratumoral CD8+ TILs was associated with chemo-responsiveness. Moreover, CD8+ TIL status in residual tumors after PST may be used as a potential prognostic marker in breast cancer patients who receive PST and provide additional prognostic information to chemo-resistant group. | Ahn, Soomin; Chung, Yul Ri; Seo, An Na; Kim, Milim; Woo, Ji Won; Park, So Yeon | Seoul Natl Univ, Bundang Hosp, Dept Pathol, Seongnam, Gyeonggi, South Korea; Seoul Natl Univ, Coll Med, Dept Pathol, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Pathol, Daegu, South Korea | ; Park, So/A-2621-2012 | 54893655800; 56578917900; 55804153700; 57202224676; 57211322355; 57049820300 | sypmd@snu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 15 | 5 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 3.24 | 35.4 | 0.68 | 2025-06-25 | 17 | 17 | PATHOLOGICAL COMPLETE RESPONSE; T-CELL SUBSETS; NEOADJUVANT CHEMOTHERAPY; RESIDUAL DISEASE; IMMUNITY; SURVIVAL; BURDEN; TRIAL | Adult; Aged; Anthracyclines; Antineoplastic Agents; Breast Neoplasms; CD4 Antigens; CD8 Antigens; Female; Forkhead Transcription Factors; Humans; Lymphocytes, Tumor-Infiltrating; Middle Aged; Neoplasm Staging; Neoplasm, Residual; Prognosis; Survival Analysis; Taxoids; Treatment Outcome; cyclophosphamide; doxorubicin; transcription factor FOXP3; anthracycline; antineoplastic agent; CD4 antigen; CD8 antigen; forkhead transcription factor; FOXP3 protein, human; taxoid; adult; aged; Article; breast cancer; cancer prognosis; cancer staging; CD4+ T lymphocyte; CD8+ T lymphocyte; clinical effectiveness; clinical feature; dose response; drug effect; drug efficacy; female; human; major clinical study; male; minimal residual disease; multiple cycle treatment; survival rate; systemic therapy; treatment outcome; tumor associated leukocyte; breast tumor; immunology; metabolism; middle aged; pathology; prognosis; survival analysis; tumor associated leukocyte | English | 2020 | 2020-05-13 | 10.1371/journal.pone.0233037 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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