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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | A Ripple-Based Real-Time Built-in-Resistance Compensation for Switching Battery Charger Achieving Fast Charging | This brief describes a real-time built-in-resistance (BIR) compensation for a switching charger designed to achieve fast charging. The proposed BIR detection utilizes the ripple components of the switching charger, enabling the detection of the BIR information at every switching cycle. The proposed BIR compensation can continuously detect the BIR information, thereby allowing the battery to be charged in constant-current (CC) mode for almost the entire charging period. The proposed switching charger has been implemented in a 0.18 mu m CMOS process, occupying a die area of 0.205mm(2). The switching charger with the proposed BIR detection can charge in CC mode up to 98%, with CC mode charging time occupying 92.7% of the total charging time. The total charging time is reduced by 38.8% compared to conventional charging architecture. A peak efficiency of 95% is achieved. | Park, Geuntae; Yeo, Seongil; Park, Chanjung; Cho, Kunhee | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | 59325087800; 58531199600; 59325267100; 57069360800 | kunhee@knu.ac.kr; | IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS | IEEE T CIRCUITS-II | 1549-7747 | 1558-3791 | 71 | 11 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2024 | 4.9 | 21.7 | 0 | 2025-05-07 | 0 | 0 | Switches; Batteries; Pulse width modulation; Sensors; Circuits; Real-time systems; Battery charger; built-in-resistance (BIR); fast charging; switching charger; ripple-based detection; ripple-based detection | LI-ION BATTERY | Battery charger; built-in-resistance (BIR); fast charging; ripple-based detection; switching charger | Charging stations; Battery chargers; Build-in-resistance; Charging time; Constant current mode; Fast charging; Real- time; Ripple component; Ripple-based detection; Switching charger; Switching cycles; State of charge | English | 2024 | 2024-11 | 10.1109/tcsii.2024.3456470 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Adaptive Identification of the Position-independent Geometric Errors for the Rotary Axis of Five-axis Machine Tools to Directly Improve Workpiece Geometric Errors | Identification of, and compensation for, geometric errors is a cost-effective way to reduce the volumetric errors of five-axis machine tools and thus reduce workpiece geometric errors. An adaptive identification method is introduced to directly reduce workpiece geometric errors. We determined the relation between the root-sum-square values of geometric error sensitivity coefficients and workpiece geometric errors. Then, an optimal measurement path minimizing those values was adaptively determined to identify position-independent geometric errors of the rotary axis. We applied our method to improve the radial deviation of the cone-shaped ISO 10791-7 testpiece, as an example. The radial deviations were 22.6 and 27.6 mu m in the counterclockwise (CCW) and clockwise (CW) directions, respectively, after compensating for the position-independent geometric errors identified using a common measurement path. These values improved by 27% and 17% to 16.4 and 22.9 mu m in the CCW and CW directions, respectively, after compensating for the position-independent geometric errors identified using the optimal measurement path, thus confirming the validity of our approach. | Yang, Seung-Han; Lee, Kwang-Il | Kyungpook Natl Univ, Sch Mech Engn, 80 Daehak Ro, Daegu 41566, South Korea; Kyungil Univ, Sch Mech & Automot Engn, 50 Gamasil Gil, Gyeonsan Si 38428, Gyeongbuk, South Korea | 8407949900; 57196250383 | syang@knu.ac.kr;kilee@kiu.kr; | INTERNATIONAL JOURNAL OF PRECISION ENGINEERING AND MANUFACTURING | INT J PRECIS ENG MAN | 2234-7593 | 2005-4602 | 25 | 5 | SCIE | ENGINEERING, MANUFACTURING;ENGINEERING, MECHANICAL | 2024 | 3.6 | 21.7 | 1.66 | 2025-05-07 | 5 | 5 | Adaptive identification; Position-independent geometric error; Measurement uncertainty; Sensitivity coefficient; Workpiece geometric error | LOCATION ERRORS; COMPENSATION; AXES; MOTIONS; TESTS; CALIBRATION; METHODOLOGY; DEVIATIONS | Adaptive identification; Measurement uncertainty; Position-independent geometric error; Sensitivity coefficient; Workpiece geometric error | Cost effectiveness; Errors; Machine tools; Uncertainty analysis; Adaptive identification; Five-axis machine tools; Geometric errors; Measurement uncertainty; Position-independent geometric error; Rotary axis; Sensitivity coefficient; Workpiece; Workpiece geometric error; Geometry | English | 2024 | 2024-05 | 10.1007/s12541-024-00966-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Deep U-NET Based Heating Film Defect Inspection System | This study introduces a real-time, high-resolution image inspection system that utilizes multiple cameras and deep learning algorithms for the real-time detection of pinholes and scratches on large-area heating films. To accommodate the repetitive inspection processes inherent in products with consistent patterns, the system operates at the region level rather than the frame level. By modifying the U-Net architecture, the system achieved precise segmentation of the inspection area, enabling real-time detection of microscale pinholes and scratches. Additionally, a sticker marker was developed to label the defective regions detected on the film. The proposed system was experimentally validated in an actual production environment, where it demonstrated an impressive 96.6% accuracy in area inspection and a 97.5% defect detection rate at a transportation speed of 12 m/min. These results serve as clear evidence of the effectiveness and practicality of the automatic detection capability facilitated by deep learning in production processes. | Hwang, J. W.; Park, H. J.; Yi, H. | Kyungpook Natl Univ, Depart Mech Engn, 80Daehak Ro, Daegu 41566, South Korea | 58866265700; 57212660551; 56567311000 | hwangjwResearch@gmail.com;phj0917@knu.ac.kr;yihak@knu.ac.kr; | INTERNATIONAL JOURNAL OF PRECISION ENGINEERING AND MANUFACTURING | INT J PRECIS ENG MAN | 2234-7593 | 2005-4602 | 25 | 4 | SCIE | ENGINEERING, MANUFACTURING;ENGINEERING, MECHANICAL | 2024 | 3.6 | 21.7 | 0.33 | 2025-05-07 | 1 | 1 | Machine vision; U-Net; Deep learning; Automated production; Real-time defect detection; Heating film | IMAGE | Automated production; Deep learning; Heating film; Machine vision; Real-time defect detection; U-Net | Computer vision; Deep learning; Defects; Inspection equipment; Learning algorithms; Learning systems; Signal detection; Automated productions; Deep learning; Defect detection; Film defects; Heating film; Machine-vision; Real- time; Real-time defect detection; Real-time detection; U-net; Inspection | English | 2024 | 2024-04 | 10.1007/s12541-023-00937-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Genetic network structure of 13 psychiatric disorders in the general population | Psychiatric disorders frequently co-occur and share common symptoms and genetic backgrounds. Previous research has used genome-wide association studies to identify the interrelationships among psychiatric disorders and identify clusters of disorders; however, these methods have limitations in terms of their ability to examine the relationships among disorders as a network structure and their generalizability to the general population. In this study, we explored the network structure of the polygenic risk score (PRS) for 13 psychiatric disorders in a general population (276,249 participants of European ancestry from the UK Biobank) and identified communities and the centrality of the network. In this network, the nodes represented a PRS for each psychiatric disorder and the edges represented the connections between nodes. The psychiatric disorders comprised four robust communities. The first community included attention-deficit hyperactivity disorder, autism spectrum disorder, major depressive disorder, and anxiety disorder. The second community consisted of bipolar I and II disorders, schizophrenia, and anorexia nervosa. The third group included Tourette's syndrome and obsessive-compulsive disorder. Cannabis use disorder, alcohol use disorder, and post-traumatic stress disorder make up the fourth community. The PRS of schizophrenia had the highest values for the three metrics (strength, betweenness, and closeness) in the network. Our findings provide a comprehensive genetic network of psychiatric disorders and biological evidence for the classification of psychiatric disorders. | Ihm, Hong Kyu; Kim, Hyejin; Kim, Jinho; Park, Woong-Yang; Kang, Hyo Shin; Park, Jungkyu; Won, Hong-Hee; Myung, Woojae | Seoul Natl Univ, Dept Neuropsychiat, Bundang Hosp, 29 Gumi Ro, Seongnam Si 13619, Gyeonggi Do, South Korea; Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol SAIHST, Samsung Med Ctr, 81 Irwon Ro, Seoul 06351, South Korea; Seoul Natl Univ, Precis Med Ctr, Future Innovat Res Div, Bundang Hosp, Seongnam, South Korea; Sungkyunkwan Univ, Samsung Genome Inst, Samsung Med Ctr, Sch Med, Seoul, South Korea; Kyungpook Natl Univ, Dept Psychol, Daegu, South Korea; Seoul Natl Univ, Coll Med, Dept Psychiat, Seoul, South Korea | Won, Hong-Hee/D-2672-2011; Myung, Woojae/AAD-3016-2021; Kim, Youl-Ri/AAE-5170-2021 | 57867250000; 59447226700; 57892423700; 7402229389; 57219595147; 56206565000; 34573851600; 37099034100 | wonhh@skku.edu;wmyung@snu.ac.kr; | EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | EUR ARCH PSY CLIN N | 0940-1334 | 1433-8491 | 274 | 5 | SCIE | CLINICAL NEUROLOGY;PSYCHIATRY | 2024 | 3.7 | 21.7 | 1.33 | 2025-05-07 | 4 | 4 | Clusters; Genetic network; Psychiatric disorder; Schizophrenia; Polygenic risk score | RISK; SCHIZOPHRENIA | Clusters; Genetic network; Polygenic risk score; Psychiatric disorder; Schizophrenia | Adult; Aged; Female; Gene Regulatory Networks; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Male; Mental Disorders; Middle Aged; Multifactorial Inheritance; United Kingdom; adult; aged; alcoholism; ancestry group; anorexia nervosa; anxiety disorder; Article; attention deficit hyperactivity disorder; autism; bipolar I disorder; bipolar II disorder; bootstrapping; cannabis addiction; Caucasian; closeness centrality; community assessment; disease classification; female; gene network analysis; genetic risk score; genome-wide association study; genotyping; Gilles de la Tourette syndrome; human; major clinical study; major depression; male; mental disease; nodal betweenness; obsessive compulsive disorder; population; posttraumatic stress disorder; schizophrenia; UK Biobank; epidemiology; gene regulatory network; genetic predisposition; genetics; middle aged; multifactorial inheritance; United Kingdom | English | 2024 | 2024-08 | 10.1007/s00406-023-01601-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | High Friction, Durability Non-slip Pads Consisting of Fluoroelastomer with Microstructures for High Vacuum and High Temperature | Fluoroelastomer (FKM), a thermosetting elastomer, stands out with its excellent friction characteristics and exceptional attributes of chemical, vacuum, and heat resistance, setting it apart from typical rubber materials. Leveraging these qualities, FKM emerges as the optimal material for friction pads used in extreme environments requiring high temperatures and vacuum, such as space and semiconductor processes. In this study, we introduce micropatterned bolt-inserted FKM pads (BIFP) designed to enhance friction, productivity, and usability. To produce BIFPs with improved friction characteristics, various microstructures were designed and tested for their friction performance. Additionally, to meet the demand for extended durability, we conducted 500,000-cycle repetitive tests. In terms of performance, durability, and usability, the developed BIFPs will be utilized widely, especially in industrial settings requiring harsh operating conditions. | Kim, Hyo Sung; Kwak, Moon Kyu; Lee, Sung Ho | Kyungpook Natl Univ, Dept Mech Engn, Daegu 41566, South Korea; Dong A Univ, Dept Mech Engn, Pusan 49315, South Korea | Kwak, Moon/F-2786-2012 | 59283618800; 57203947984; 56195582600 | mkkwak@knu.ac.kr;sunghol@dau.ac.kr; | INTERNATIONAL JOURNAL OF PRECISION ENGINEERING AND MANUFACTURING | INT J PRECIS ENG MAN | 2234-7593 | 2005-4602 | 25 | 10 | SCIE | ENGINEERING, MANUFACTURING;ENGINEERING, MECHANICAL | 2024 | 3.6 | 21.7 | 0.33 | 2025-05-07 | 1 | 1 | Fluoroelastomer (FKM); Friction; VESPEL; Micropattern; Semiconductor manufacturing | FKM O-RING; DRY ADHESIVE; SEALS | Fluoroelastomer (FKM); Friction; Micropattern; Semiconductor manufacturing; VESPEL | Durability; Heat resistance; Microstructure; Rubber; Semiconductor device manufacture; Vacuum applications; Fluoroelastomer (FKM); Fluoroelastomers; Friction characteristics; High vacuum; Highest temperature; Micro pattern; Rubber material; Semiconductor manufacturing; Thermosetting elastomers; VESPEL; Friction | English | 2024 | 2024-10 | 10.1007/s12541-024-01040-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Interpersonal sensitivity and childhood trauma in patients with major depressive disorder, bipolar I, and II disorder | Childhood trauma and interpersonal sensitivity impact the development of mood disorders. In this study, we investigate the association between childhood trauma and interpersonal sensitivity in patients with mood disorders. A total 775 patients (major depressive disorder [MDD, n = 241], bipolar I disorder [BD I, n = 119], and bipolar II disorder [BD II, n = 415]) and 734 controls. For evaluation, we used the Childhood Trauma Questionnaire-Short Form (CTQ) and Interpersonal Sensitivity Measure (IPSM). We examined between-group differences for each subscale in the CTQ and IPSM. Patients with BD II had significantly higher IPSM total scores than patients with MDD, BD I, or controls. The CTQ total score was related to the IPSM total score in all participants and subgroups. Among the CTQ subscales, emotional abuse showed the highest correlation with the IPSM total score, while separation anxiety and fragile inner self showed higher positive correlations with CTQ than the other subscales of IPSM in all patient groups and the control group, respectively. The findings reveal that childhood trauma and interpersonal sensitivity are positively correlated among patients with MDD, BD I, and BD II, and that interpersonal sensitivity is higher in patients with BD II than those with BD I or MDD. Childhood trauma is associated with interpersonal sensitivity, and each trauma type has a different impact on mood disorders. We expect that this study will encourage future research on interpersonal sensitivity and childhood trauma in mood disorders to improve treatment approaches. | Kwon, Sarah Soonji; Jang, Yoonjeong; You, Ji Seon; Lee, Chan Woo; Yu, Hyeona; Yoon, Joohyun; Park, Yun Seong; Ryoo, Hyun A.; Lee, Daseul; Cho, Nayoung; Ihm, Hong Kyu; Lee, Yeong Chan; Won, Hong-Hee; Kang, Hyo Shin; Ha, Tae Hyon; Myung, Woojae | Seoul Natl Univ, Bundang Hosp, Dept Neuropsychiat, 29,Gumi Ro 173 Beon Gil, Seongnam Si 13619, Gyeonggi Do, South Korea; Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Dept Hlth Sci & Technol, Seoul, South Korea; Asan Med Ctr, Dept Psychiat, Seoul, South Korea; Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol SAIHST, Samsung Med Ctr, Seoul, South Korea; Kyungpook Natl Univ, Dept Psychol, Daegu, South Korea; Seoul Natl Univ, Coll Med, Dept Psychiat, Seoul, South Korea | Myung, Woojae/AAD-3016-2021; Ha, Tae/U-5558-2019; Park, Christopher/L-6074-2017; Jang, Yoonjeong/LKN-3419-2024; Won, Hong-Hee/D-2672-2011 | 57973200800; 57223872445; 57914489900; 57230186200; 57910913300; 57226706803; 57212764489; 57230578700; 57973764300; 57230969400; 57867250000; 57210554111; 34573851600; 57219595147; 7203014550; 37099034100 | wmyung@snu.ac.kr; | EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | EUR ARCH PSY CLIN N | 0940-1334 | 1433-8491 | 274 | 3 | SCIE | CLINICAL NEUROLOGY;PSYCHIATRY | 2024 | 3.7 | 21.7 | 1.99 | 2025-05-07 | 7 | 7 | Childhood trauma; Interpersonal sensitivity; Major depressive disorder; Bipolar disorders | SEXUAL-ABUSE; DSM-IV; AFFECTIVE TEMPERAMENTS; MEDIATING ROLE; SYMPTOMS; EMOTION; PREVALENCE; VALIDATION; VERSION; EVENTS | Bipolar disorders; Childhood trauma; Interpersonal sensitivity; Major depressive disorder | Adverse Childhood Experiences; Bipolar Disorder; Childhood Trauma Questionnaire; Depressive Disorder, Major; Humans; Psychological Tests; Self Report; Surveys and Questionnaires; adult; Article; bipolar I disorder; bipolar II disorder; childhood trauma; Childhood Trauma Questionnaire; controlled study; emotional abuse; female; human; major clinical study; major depression; male; separation anxiety; bipolar disorder; childhood adversity; complication; psychologic test; psychology; questionnaire; self report | English | 2024 | 2024-04 | 10.1007/s00406-023-01619-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Network structure of symptomatology of adult attention-deficit hyperactivity disorder in patients with mood disorders | Patients with mood disorders commonly manifest comorbid psychiatric disorders, including attention-deficit/hyperactivity disorder (ADHD). However, few studies have evaluated ADHD symptoms in this population. The current study aimed to explore the network structure of ADHD symptomology and identify central symptoms in patients with mood disorders. The Korean version of the Adult ADHD Self-Report Scale was used to assess the overall ADHD symptoms in 1,086 individuals diagnosed with mood disorders (major depressive disorder [n = 373], bipolar I disorder [n = 314], and bipolar II disorder [n = 399]). We used exploratory graph analysis to detect the number of communities, and the network structure was analyzed using regularized partial correlation models. We identified the central ADHD symptom using centrality indices. Network comparison tests were conducted with different subgroups of patients with mood disorders, including three mood diagnosis groups, between the patients who met the diagnostic criteria for ADHD [ADHD-suspected, n = 259] in their self-report and the others [ADHD-non-suspected, n = 827], and groups with high [n = 503] versus low [n = 252] levels of depressive state. The network analysis detected four communities: disorganization, agitation/restlessness, hyperactivity/impulsivity, and inattention. The centrality indices indicated that "feeling restless" was the core ADHD symptom. The result was replicated in the subgroup analyses within our clinically diverse population of mood disorders, encompassing three presentations: Patients with suspected ADHD, patients without suspected ADHD, and patients with a high depressive state. Our findings reveal that "feeling restless" is the central ADHD symptom. The treatment intervention for "feeling restless" may thus play a pivotal role in tackling ADHD symptoms in adult patients with mood disorders. | Lee, Jakyung; Lee, Daseul; Ihm, Hongkyu; Kang, Hyo Shin; Yu, Hyeona; Yoon, Joohyun; Jang, Yoonjeong; Kim, Yuna; Lee, Chan Woo; Lee, Hyukjun; Baek, Ji Hyun; Ha, Tae Hyon; Park, Jungkyu; Myung, Woojae | Seoul Natl Univ, Bundang Hosp, Dept Neuropsychiat, 29,Gumi Ro 173 Beon Gil Bundang Gu, Seongnam 13619, Gyeonggi Do, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Psychiat, Seoul, South Korea; Kyungpook Natl Univ, Dept Psychol, 80 Daehak Ro,Buk Gu, Daegu 41566, South Korea; Seoul Natl Univ, Coll Med, Dept Psychiat, Seoul, South Korea | Baek, Ji Hyun/JJF-8250-2023; Ha, Tae/U-5558-2019; Jang, Yoonjeong/LKN-3419-2024; Myung, Woojae/AAD-3016-2021 | 57972918600; 57973764300; 57867250000; 57219595147; 57910913300; 57226706803; 57223872445; 58553547100; 57230186200; 58749939700; 35302022000; 7203014550; 56206565000; 37099034100 | jkp@knu.ac.kr;wmyung@snu.ac.kr; | EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | EUR ARCH PSY CLIN N | 0940-1334 | 1433-8491 | 274 | 7 | SCIE | CLINICAL NEUROLOGY;PSYCHIATRY | 2024 | 3.7 | 21.7 | 0.66 | 2025-05-07 | 1 | 1 | Network analysis; Adult ADHD symptomatology; Mood disorders; Major depressive disorder; Bipolar disorder | REPORT SCALE ASRS; PSYCHOMOTOR AGITATION; BIPOLAR DISORDER; ADHD; DEPRESSION; SYMPTOMS; COMORBIDITY; PREVALENCE; TRANSITION; CHILDHOOD | Adult ADHD symptomatology; Bipolar disorder; Major depressive disorder; Mood disorders; Network analysis | Adult; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Comorbidity; Depressive Disorder, Major; Female; Humans; Male; Middle Aged; Mood Disorders; Young Adult; adult; Adult ADHD Self-Report Scale; agitation; Article; attention deficit hyperactivity disorder; betweenness centrality; bipolar disorder; centrality index; controlled study; depression; female; human; hyperactivity; impulsiveness; intimacy; major clinical study; male; mood disorder; network analysis; questionnaire; restlessness; self report; strength; symptomatology; Zung Self Rating Depression Scale; bipolar disorder; comorbidity; complication; major depression; middle aged; mood disorder; pathophysiology; young adult | English | 2024 | 2024-10 | 10.1007/s00406-023-01719-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Sector Bound-Dependent Matrix-Separation-Based Inequality and its Application to Stability Analysis of Discrete-Time Delayed Genetic Regulatory Networks | In this brief, a class of sector bound-dependent matrix-separation-based inequality is proposed that can utilize the properties of nonlinear functions to overcome the weaknesses of existing estimation methods. Then, an expanded class of Lyapunov-Krasovskii functional is constructed to include some integral terms of the sector constraint of nonlinear functions. By applying the improved inequality, the stability criterion of genetic regulatory networks (GRNs) with stochastic perturbations and time-varying delay is established. The validity of presented criterion and the advancement of proposed method are analysed based on two examples. | Xie, Ke-You; Zhang, Chuan-Ke; Lee, Sangmoon; Liu, Yajuan; Zhai, Chao | China Univ Geosci, Sch Automat, Hubei Key Lab Adv Control & Intelligent Automat, Minist Educ, Wuhan 430074, Peoples R China; China Univ Geosci, Engn Res Ctr Intelligent Technol Geoexplorat, Minist Educ, Wuhan 430074, Peoples R China; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; North China Elect Power Univ, Sch Control & Comp Engn, Beijing 102206, Peoples R China | Xie, Ke-You/HHS-5859-2022; Lee, Sangmoon/C-4502-2018; Yajuan, Liu/JZD-8537-2024; Lee, Seunghoon/AAR-6570-2020; Zhang, Chuan-Ke/L-7727-2016 | 57211609242; 55557210100; 59510733500; 55255775300; 56187575100 | xiekeyou@cug.edu.cn;ckzhang@cug.edu.cn;moony@knu.ac.kr;yajuan.liu.12@gmail.com;zhaichao@amss.ac.cn; | IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS | IEEE T CIRCUITS-II | 1549-7747 | 1558-3791 | 71 | 8 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2024 | 4.9 | 21.7 | 0.4 | 2025-04-16 | 2 | 2 | Linear matrix inequalities; Stability criteria; Estimation; Delays; Symmetric matrices; Numerical stability; Circuit stability; Sector bound-dependent summation inequality; genetic regulatory networks; time-varying delay; stability | NEURAL-NETWORKS; CRITERIA; SYSTEMS | genetic regulatory networks; Sector bound-dependent summation inequality; stability; time-varying delay | Delay circuits; Delay control systems; Linear matrix inequalities; Linear networks; Robustness (control systems); Stochastic systems; Time delay; Time varying control systems; Time varying networks; Timing circuits; Circuit stability; Delay; Genetic regulatory networks; Linear matrix in equalities; Matrix separation; Nonlinear functions; Sector bound-dependent summation inequality; Stability criterions; Symmetric matrices; Time-varying delay; Stability criteria | English | 2024 | 2024-08 | 10.1109/tcsii.2024.3367777 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Single-Rating Multilevel Current Source Inverter With Fault Tolerance | The paralleled H-bridge multilevel current source inverter (PHB-MLCSI) provides a practical means to enhance both the system's current rating and power quality simultaneously. Even so, challenges such as separate dc sources and the need for bulky input dc inductors present notable obstacles in the PHB-MLCSI with an independent dc-link configuration, potentially increasing the system's cost and size. The PHB-MLCSI with a shared dc-link, also known as the single-rating MLCSI (SR-MLCSI), can overcome these limitations. However, the SR-MLCSI faces the issue of open-circuit fault (OCF), similar to other traditional CSIs. Recently, a topology known as paralleled H-bridge multilevel switching-cell current source inverter (PHB-MLSC2SI) has been proposed in the literature to address the OCF issue in conventional PHB-MLCSI. However, this topology retains the same limitations as those mentioned for PHB-MLCSI. This article proposes a modified version of SR-MLCSI, termed SR-MLCSI with fault tolerance (SR-MLCSIFT), to address the OCF issue in SR-MLCSI and mitigate the size, weight, cost, and complexity drawbacks of PHB-MLCSI and PHB-MLSC2SI. Additionally, the article investigates several extremely severe faulty scenarios for the first time within the proposed topology. A detailed operational principle of the suggested inverter under OCF conditions is provided, accompanied by a comprehensive comparison with several MLCSI counterparts. Extensive experimental tests are conducted to validate the effectiveness of the proposed solution. | Faraji, Faramarz; Cha, Honnyong | Kyungpook Natl Univ, Sch Energy Engn, Daegu 41566, South Korea | Faraji, Faramarz/J-4074-2019 | 57191226987; 24450248400 | faraji.u@gmail.com;chahonny@knu.ac.kr; | IEEE JOURNAL OF EMERGING AND SELECTED TOPICS IN POWER ELECTRONICS | IEEE J EM SEL TOP P | 2168-6777 | 2168-6785 | 12 | 5 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2024 | 4.9 | 21.7 | 0.35 | 2025-04-16 | 0 | 1 | Multilevel current source inverter (MLCSI); open-circuit fault (OCF); phase-shifted pulsewidth modulation (PWM); reliability; shoot-through issue | CURRENT-SOURCE CONVERTER; VOLTAGE; CELL; TOPOLOGIES; BALANCE | Multilevel current source inverter (MLCSI); open-circuit fault (OCF); phase-shifted pulsewidth modulation (PWM); reliability; shoot-through issue | Bridge circuits; Electric inverters; Fault tolerance; Power quality; Pulse width modulation; Timing circuits; Circuit faults; Current source inverter; Inductor; Inverter; Multilevel current source inverte; Multilevels; Open-circuit fault; Phase-shifted PWM; Pulsewidth modulations (PWM); Shoot-through; Shoot-through issue; Topology | English | 2024 | 2024-10 | 10.1109/jestpe.2024.3432888 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Split-Capacitor-Based Isolated Double Step-Down DC-DC Converter | This article introduces a novel isolated high stepdown dc-dc converter. The introduced converter can offer the low voltage stress of power switches on the primary side. The introduced converter also achieves a zero-voltage-switching turnon for all power switches and avoids the transformer saturation problem. By using a split-capacitor double step-down structure, the introduced converter also reduces the input capacitance and eliminates the high voltage stress during the start-up process. The introduced converter is ready to be connected to a three-level NPC inverter with self-balanced voltages in two capacitors of the dc link. The operating principle and comparative study of the introduced converter are presented in detail. A 1-kW 400-/48-V laboratory prototype was implemented to validate the feasibility of the introduced converter. | Truong-Duy Duong; Minh-Khai Nguyen; Wang, Caisheng; Bang Le-Huy Nguyen; Cha, Honnyong | Wayne State Univ, Dept Elect & Comp Engn, Detroit, MI 48202 USA; Gen Motors, Warren, MI 48093 USA; Duy Tan Univ, Sch Engn & Technol, Da Nang 550000, Vietnam; Duy Tan Univ, Inst Res & Dev, Da Nang 550000, Vietnam; Kyungpook Natl Univ, Sch Energy Engn, Daegu 41566, South Korea | ; DUONG, TRUONG DUY/AAC-8566-2019; Nguyen, Minh-Khai/A-2379-2016 | 57194726686; 35077214500; 23111449000; 57211273880; 24450248400 | duydt@wayne.edu;minh-khai.nguyen@gm.com;cwang@wayne.edu;bangnguyen@ieee.org;chahonny@knu.ac.kr; | IEEE JOURNAL OF EMERGING AND SELECTED TOPICS IN POWER ELECTRONICS | IEEE J EM SEL TOP P | 2168-6777 | 2168-6785 | 12 | 5 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2024 | 4.9 | 21.7 | 0.7 | 2025-04-16 | 2 | 3 | High step-down; low voltage stress; phase shift full-bridge (PSFB) converter; soft switching; start-up | FULL-BRIDGE CONVERTER; REDUCED CIRCULATING LOSSES; VOLTAGE STRESS; DESIGN; RECTIFIER | High step-down; low voltage stress; phase shift full-bridge (PSFB) converter; soft switching; start-up | Capacitance; Electric inverters; Zero voltage switching; DC/DC power converters; High step-down; Inductor; Low voltages; Lower voltage stress; Phase shift full bridge converters; Soft-switching; Start-up; Step down; Zero- Voltage Switching; DC-DC converters | English | 2024 | 2024-10 | 10.1109/jestpe.2024.3426932 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Cell-Free Supernatant of Vaginal Viridans Streptococcus Induces Membrane Permeabilization and Transcriptional Regulation in Methicillin-Resistant Staphylococcus aureus | The genus Streptococcus is a heterogenous group of commensal and pathogenic bacteria that are normal inhabitants of the human body, including the female genital tract (FGT). In the FGT microbiome, streptococci represent two major groups: the pathogenic group B Streptococci (GBS) and the commensal viridans group streptococci (VGS). Though members of the VGS are frequently detected from the FGT, their role in the FGT microbiome remains underexplored. Here, we report the characterization of Streptococcus sp. K0074, isolated from the vaginal swab of an endometrial cancer patient admitted to the hospital, with no evidence of bacterial vaginosis. Phylogenetic analysis revealed that the strain is a member of the commensal VGS and possibly represents a novel species in the mitis subgroup. The strain demonstrated the production of low molecular weight bacteriocin-like substance with narrow-spectrum antagonistic activity, affecting the growth, biofilm formation, and colonization of aerobic vaginitis (AV)–causing bacterium methicillin-resistant Staphylococcus aureus (MRSA). The putative bacteriocin exhibited cell membrane–permeabilizing activity and exerted negative regulatory effect on the accessory gene regulator and SaeRS two-component systems of MRSA. Collectively, our results suggest that the isolate may modulate the FGT microbiome by inhibiting or displacing specific pathogen. Furthermore, the results presented here highlight new perspectives regarding the existence of VGS in the FGT microbiome and in particular pinpoint the potential clinical significance of the isolated VGS strain Streptococcus sp. K0074 for the treatment of AV caused by MRSA. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. | Montecillo, Jake Adolf V.; Yoo, Heon Jong; Lee, Yoo-Young; Park, Chulmin; Cho, Angela; Lee, Hyunsu; Park, Nora Jee-Young; Han, Hyung Soo; Chong, Gun Oh; Seo, Incheol | Department of Immunology, School of Medicine, Kyungpook National University, 680 Gukchaebosang-Ro, Jung-Gu, Daegu, 41944, South Korea, Clinical Omics Institute, Kyungpook National University, Daegu, 41405, South Korea, Brain Korea 21 FOUR Program, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; Center for Gynecologic Cancer, National Cancer Center, Goyang, 10408, South Korea, Chungnam National University School of Medicine, Daejeon, 35015, South Korea; Gynecologic Cancer Center, Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 06351, South Korea; Department of Obstetrics and Gynecology, Jeju National University Hospital, Jeju National University College of Medicine, Jeju, 35015, South Korea; Department of Obstetrics and Gynecology, Jeju National University Hospital, Jeju National University College of Medicine, Jeju, 35015, South Korea; Department of Physiology, Pusan National University School of Medicine, Yangsan, 50612, South Korea; Clinical Omics Institute, Kyungpook National University, Daegu, 41405, South Korea, Department of Pathology, Kyungpook National University Chilgok Hospital, Daegu, 41404, South Korea; Clinical Omics Institute, Kyungpook National University, Daegu, 41405, South Korea, Brain Korea 21 FOUR Program, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea, Department of Physiology, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; Clinical Omics Institute, Kyungpook National University, Daegu, 41405, South Korea, Department of Obstetrics and Gynecology, Kyungpook National University Chilgok Hospital, 807 Hoguk-Ro, Buk-Gu, Daegu, 41404, South Korea; Department of Immunology, School of Medicine, Kyungpook National University, 680 Gukchaebosang-Ro, Jung-Gu, Daegu, 41944, South Korea, Clinical Omics Institute, Kyungpook National University, Daegu, 41405, South Korea, Brain Korea 21 FOUR Program, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea | 57215828146; 39362841900; 29767612900; 57200324105; 57220102675; 56335508500; 57226185359; 7401969388; 23099068000; 56022683900 | iseo@knu.ac.kr;gochong@knu.ac.kr; | Probiotics and Antimicrobial Proteins | PROBIOTICS ANTIMICRO | 1867-1306 | 1867-1314 | SCIE | MICROBIOLOGY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 4.4 | 21.8 | 0 | 2025-05-07 | 0 | Bacteriocin; Microbiome; MRSA; Streptococcus; Vagina; Viridans | English | Article in press | 2024 | 10.1007/s12602-024-10412-2 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Development and validation of a prediction model for postoperative urinary retention after prolapse surgery: A retrospective cohort study | Background Postoperative urinary retention (POUR), a common condition after prolapse surgery with potential serious sequelae if left untreated, lacks a clearly established optimal timing for catheter removal. This study aimed to develop and validate a predictive model for postoperative urinary retention lasting > 2 and > 4 days after prolapse surgery. Methods We conducted a retrospective review of 1,122 patients undergoing prolapse surgery. The dataset was divided into training and testing cohorts. POUR was defined as the need for continuous intermittent catheterization resulting from a failed spontaneous voiding trial, with passing defined as two consecutive voids >= 150 mL and a postvoid residual urine volume 2 and > 4 days, respectively. Multivariable logistic model identified 6 predictors. For predicting POUR, internal validation using cross-validation approach showed good performance, with accuracy lasting > 2 (area under the curve [AUC] 0.73) and > 4 days (AUC 0.75). Split validation using pre-separated dataset also showed good performance, with accuracy lasting > 2 (AUC 0.73) and > 4 days (AUC 0.74). Calibration curves demonstrated that the model accurately predicted POUR lasting > 2 and > 4 days (from 0 to 80%). Conclusions The proposed prediction model can assist clinicians in personalizing postoperative bladder care for patients undergoing prolapse surgery by providing accurate individual risk estimates. | Kim, Min Ju; Lee, Sungyoung; Lee, So Yeon; Oh, Sumin; Jeon, Myung Jae | Kyungpook Natl Univ, Chilgok Hosp, Dept Obstet & Gynecol, Daegu, South Korea; Seoul Natl Univ Hosp, Dept Genom Med, Seoul, South Korea; Gangseo MizMidi Hosp, Dept Obstet & Gynecol, Seoul, South Korea; Korea Univ, Guro Hosp, Dept Obstet & Gynecol, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Obstet & Gynecol, 103 Daehak Ro, Seoul 03080, South Korea; Seoul Natl Univ Hosp, Dept Obstet & Gynecol, Seoul, South Korea | Lee, Hye/J-2154-2015; Lee, Yeong Yeh/G-2470-2010; Jeon, Myung/J-5634-2012 | 58638895300; 55716390100; 57214899201; 57221461466; 8131985300 | jeonmj@snu.ac.kr; | BMC WOMENS HEALTH | BMC WOMENS HEALTH | 1472-6874 | 24 | 1 | SCIE;SSCI | OBSTETRICS & GYNECOLOGY;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2024 | 2.7 | 21.8 | 0 | 2025-05-07 | 0 | 0 | Clinical decision-making; Pelvic organ prolapse; Urinary retention | LONG-TERM CATHETERIZATION; TRIAL COMPARING SHORT; VAGINAL PROLAPSE; RISK; INCONTINENCE; WOMEN | Clinical decision-making; Pelvic organ prolapse; Urinary retention | Aged; Cohort Studies; Female; Humans; Logistic Models; Middle Aged; Pelvic Organ Prolapse; Postoperative Complications; Retrospective Studies; Risk Factors; Urinary Catheterization; Urinary Retention; adverse event; aged; bladder catheterization; cohort analysis; epidemiology; etiology; female; human; middle aged; pelvic organ prolapse; postoperative complication; retrospective study; risk factor; statistical model; surgery; urine retention | English | 2024 | 2024-06-07 | 10.1186/s12905-024-03171-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Gut Microbes in Polycystic Ovary Syndrome and Associated Comorbidities; Type 2 Diabetes, Non-Alcoholic Fatty Liver Disease (NAFLD), Cardiovascular Disease (CVD), and the Potential of Microbial Therapeutics | Polycystic ovary syndrome (PCOS) is one of the most common endocrine anomalies among females of reproductive age, highlighted by hyperandrogenism. PCOS is multifactorial as it can be associated with obesity, insulin resistance, low-grade chronic inflammation, and dyslipidemia. PCOS also leads to dysbiosis by lowering microbial diversity and beneficial microbes, such as Faecalibacterium, Roseburia, Akkermenisa, and Bifidobacterium, and by causing a higher load of opportunistic pathogens, such as Escherichia/Shigella, Fusobacterium, Bilophila, and Sutterella. Wherein, butyrate producers and Akkermansia participate in the glucose uptake by inducing glucagon-like peptide-1 (GLP-1) and glucose metabolism, respectively. The abovementioned gut microbes also maintain the gut barrier function and glucose homeostasis by releasing metabolites such as short-chain fatty acids (SCFAs) and Amuc₁₁₀₀ protein. In addition, PCOS-associated gut is found to be higher in gut-microbial enzyme beta-glucuronidase, causing the de-glucuronidation of conjugated androgen, making it susceptible to reabsorption by entero-hepatic circulation, leading to a higher level of androgen in the circulatory system. Overall, in PCOS, such dysbiosis increases the gut permeability and LPS in the systemic circulation, trimethylamine N-oxide (TMAO) in the circulatory system, chronic inflammation in the adipose tissue and liver, and oxidative stress and lipid accumulation in the liver. Thus, in women with PCOS, dysbiosis can promote the progression and severity of type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), and cardiovascular diseases (CVD). To alleviate such PCOS-associated complications, microbial therapeutics (probiotics and fecal microbiome transplantation) can be used without any side effects, unlike in the case of hormonal therapy. Therefore, this study sought to understand the mechanistic significance of gut microbes in PCOS and associated comorbidities, along with the role of microbial therapeutics that can ease the life of PCOS-affected women. | Singh, Vineet; Mahra, Kanika; Jung, DaRyung; Shin, Jae-Ho | Kyungpook Natl Univ, Dept Appl Biosci, Daegu, South Korea | ; shin, Jaeho/K-6792-2013; Singh, Vineet/ABC-7000-2021 | 57211642447; 58998079500; 57221116102; 57224125922 | jhshin@knu.ac.kr; | PROBIOTICS AND ANTIMICROBIAL PROTEINS | PROBIOTICS ANTIMICRO | 1867-1306 | 1867-1314 | 16 | 5 | SCIE | MICROBIOLOGY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 4.4 | 21.8 | 1.2 | 2025-05-07 | 10 | 10 | Gut microbes; Microbial metabolites; PCOS; Obesity; Insulin resistance; Diabetes; NAFLD; CVD; Probiotics; Fecal microbiome transplantation | CORONARY-ARTERY CALCIFICATION; DOUBLE-BLIND PLACEBO; PROBIOTIC SUPPLEMENTATION; OXIDATIVE STRESS; SYNBIOTIC SUPPLEMENTATION; INSULIN-RESISTANCE; SYNDROME PCOS; WOMEN; PREVALENCE; OBESITY | CVD; Diabetes; Fecal microbiome transplantation; Gut microbes; Insulin resistance; Microbial metabolites; NAFLD; Obesity; PCOS; Probiotics | Animals; Cardiovascular Diseases; Comorbidity; Diabetes Mellitus, Type 2; Dysbiosis; Female; Gastrointestinal Microbiome; Humans; Non-alcoholic Fatty Liver Disease; Polycystic Ovary Syndrome; androstenedione; beta glucuronidase; C reactive protein; follitropin; glucagon like peptide 1; high density lipoprotein cholesterol; luteinizing hormone; probiotic agent; short chain fatty acid; testosterone; triacylglycerol; adipose tissue; Bifidobacterium; cardiovascular disease; chronic inflammation; comorbidity; diabetes mellitus; dysbiosis; dyslipidemia; echography; Escherichia coli; Faecalibacterium; fecal microbiota transplantation; glucose homeostasis; glucose metabolism; glucuronidation; homeostasis; human; hyperandrogenism; hyperglycemia; hyperlipidemia; inflammation; insulin resistance; intestinal reabsorption; intestine flora; microbial diversity; microbiome; non insulin dependent diabetes mellitus; nonalcoholic fatty liver; obesity; ovary hyperstimulation; ovary polycystic disease; oxidative stress; pathophysiology; phosphorylation; physiological stress; Review; subfertility; animal; comorbidity; etiology; female; metabolism; microbiology; therapy | English | 2024 | 2024-10 | 10.1007/s12602-024-10262-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Lacticaseibacillus Casei IDCC 3451 Strengthen Digestibility of Plant-based Proteins in Mice | The demand for plant-based proteins as alternative meat sources continues to increase because of environmental concerns, animal welfare, and religious reasons. However, plant-based proteins have low digestibility than real meat, which should be overcome. In the present study, the effect of co-administration of legumin protein mixture and the probiotic strain on plasma concentration of amino acids was investigated as a strategy of enhancement in protein digestion. First, the proteolytic activity of the four probiotic strains was compared. As a result, Lacticaseibacillus casei IDCC 3451 was identified as an optimal probiotic strain that efficiently digested the legumin protein mixture by forming the largest halo produced by proteolysis. Next, to investigate whether the co-administration of legumin protein mixture and L. casei IDCC 3451 could synergically improve digestibility, mice were fed either a high-protein diet or a high-protein diet with L. casei IDCC 3451 for 8 weeks. Compared to only in the high-protein diet only group, the concentrations of branched chain amino acids and essential amino acids were 1.36 and 1.41 times higher in the co-administered group, respectively. Therefore, co-supplementation of plant-based proteins with L. casei IDCC 3451 can be suggested to improve protein digestibility based on the this study. | Kim, Jungyeon; Kim, Hayoung; Jeon, Hyeon Ji; Jung, Young Hoon; Yang, Jungwoo | Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USA; Ildong Biosci, Pyeongtaek Si 17957, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea | ; Jung, Young/F-1703-2013; Kim, Jinkwon/AAR-6729-2021; Jeon, Hyeon Ji/HPH-4892-2023 | 57214338692; 57451681800; 57795638700; 55550063700; 56076383700 | younghoonjung@knu.ac.kr;yjw@ildong.com; | PROBIOTICS AND ANTIMICROBIAL PROTEINS | PROBIOTICS ANTIMICRO | 1867-1306 | 1867-1314 | 16 | 3 | SCIE | MICROBIOLOGY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 4.4 | 21.8 | 1.42 | 2025-05-07 | 4 | 3 | Legumin proteins; Proteolysis; Lacticaseibacillus casei; Amino acid absorption; High-protein diet mouse model | PROTEOLYTIC ACTIVITY; QUALITY; STRAINS | Amino acid absorption; High–protein diet mouse model; Lacticaseibacillus casei; Legumin proteins; Proteolysis | Amino Acids; Animals; Digestion; Lacticaseibacillus casei; Male; Mice; Plant Proteins; Probiotics; alanine; arginine; aspartic acid; branched chain amino acid; cysteine; glutamic acid; glycine; histidine; isoleucine; legumin; leucine; lysine; methionine; phenylalanine; plant protein; proline; serine; threonine; tryptophan; tyrosine; amino acid; probiotic agent; absorption; amino acid absorption; amino acid blood level; amino acid composition; animal experiment; Article; Bifidobacterium bifidum; body weight change; controlled study; digestion; fluid intake; food intake; ion exchange chromatography; Lactobacillus casei; Lactobacillus casei idcc 3451; Lactobacillus johnsonii; Lactobacillus reuteri; leg muscle; male; mouse; muscle weight; nonhuman; protein degradation; protein diet; synergistic effect; animal; digestion; metabolism | English | 2024 | 2024-06 | 10.1007/s12602-023-10091-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Prospective direct comparison of biologic treatments for severe eosinophilic asthma Findings from the PRISM study | Background: Although various monoclonal antibodies have been used as add-on therapy for severe eosinophilic asthma (SEA), to the best of our knowledge, no direct head -to -head comparative study has evaluated their ef ficacy. Objective: To compare the ef ficacy of reslizumab, mepolizumab, and dupilumab in patients with SEA. Methods: This was a multicenter, prospective observational study in patients with SEA who had received 1 of these biologic agents for at least 6 months. Cox proportional hazard models were used to compare the risk of the first exacerbation event, adjusting for sputum or blood eosinophils and common asthma -related covariates. The annual exacerbation rate was analyzed using a negative binomial model, and a mixed -effect model was used to analyze changes in forced expiratory volume in 1 second and asthma control test score over time. Results: A total of 141 patients with SEA were included in the analysis; 71 (50%) received dupilumab; 40 (28%) received reslizumab, and 30 (21%) received mepolizumab. During the 12 -month follow-up, 27.5%, 43.3%, and 38.0% of patients in the reslizumab, mepolizumab, and dupilumab groups, respectively, experienced at least 1 exacerbation. However, after adjusting for confounding factors, the dupilumab and mepolizumab groups showed similar outcomes in time -to -first exacerbation, exacerbation rate, forced expiratory volume in 1 second, and asthma control test score to those of the reslizumab group. Conclusion: In patients with SEA, treatment with reslizumab, mepolizumab, and dupilumab resulted in comparable clinical outcomes within a 12 -month period. Trial Registration: The cohort protocol was sanctioned by the Institutional Review Board of each study center (clinicaltrial.gov identifier NCT05164939). (c) 2023 American College of Allergy, Asthma & Immunology. All rights reserved. | Pham, Duong Duc; Lee, Ji-Hyang; Kwon, Hyouk-Soo; Song, Woo -Jung; Cho, You Sook; Kim, Hyunkyoung; Kwon, Jae -Woo; Park, So -Young; Kim, Sujeong; Hur, Gyu Young; Kim, Byung Keun; Nam, Young-Hee; Yang, Min-Suk; Kim, Mi-Yeong; Kim, Sae-Hoon; Lee, Byung-Jae; Lee, Taehoon; Park, So Young; Kim, Min-Hye; Cho, Young-Joo; Park, Chansun; Jung, Jae -Woo; Park, Han Ki; Kim, Joo-Hee; Moon, Ji-Yong; Adcock, Ian; Bhavsar, Pankaj; Chung, Kian Fan; Kim, Tae -Bum | Univ Ulsan, Asan Med Ctr, Coll Med, Dept Allergy & Clin Immunol, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea; Kangwon Natl Univ, Sch Med, Dept Allergy & Clin Immunol, Chunchon, South Korea; Chung Ang Univ, Gwangmyeong Hosp, Div Pulm Allergy & Crit Care Med, Gwangmyeong, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Korea Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Korea Univ, Med Ctr, Anam Hosp, Dept Internal Med, Seoul, South Korea; Dong A Univ, Coll Med, Dept Internal Med, Busan, South Korea; Seoul Natl Univ, Boramae Med Ctr, Dept Internal Med, Seoul Metropolitan Govt, Seoul, South Korea; Inje Univ, Coll Med, Busan Paik Hosp, Dept Internal Med, Busan, South Korea; Seoul Natl Univ, Div Allergy & Clin Immunol, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul, South Korea; Univ Ulsan, Coll Med, Ulsan Univ Hosp, Dept Internal Med, Ulsan x, South Korea; Eulji Univ, Sch Med, Dept Internal Med, Seoul, South Korea; Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Ewha Womans Univ, Mokdong Hosp, Coll Med, Dept Allergy & Clin Immunol, Seoul, South Korea; Inje Univ, Haeundae Paik Hosp, Dept Internal Med, Busan, South Korea; Chung Ang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Allergy & Clin Immunol, Daegu, South Korea; Hallym Univ, Sacred Heart Hosp, Dept Internal Med, Anyang, South Korea; Hanyang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Imperial Coll London, Natl Heart & Lung Inst, London, England | Adcock, Ian/L-3217-2019; Kim, Hyun/AAT-6695-2021; Chung, Kian/B-1872-2012; Park, Han-Ki/AAY-3102-2020; MOON, Ji-Yong/U-1476-2018; Pham, Duong/D-4674-2013; Lee, Tae/B-1160-2013; Lee, JongGu/B-7384-2013; Kim, Jin-Seok/AAK-5424-2020; Jung, Jae-Woo/L-9451-2019; Kim, Ju-Hyoung/N-1450-2019; Lee, Jae-Hyun/ABE-3803-2020; Kim, Byung-Keun/N-4256-2018 | tbkim@amc.seoul.kr; | ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY | ANN ALLERG ASTHMA IM | 1081-1206 | 1534-4436 | 132 | 4 | SCIE | ALLERGY;IMMUNOLOGY | 2024 | 4.7 | 21.8 | 2 | TRIALS | English | 2024 | 2024-04 | 10.1016/j.anai.2023.11.005 | 바로가기 | 바로가기 | 바로가기 |
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