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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | pKr-2 induces neurodegeneration via upregulation of microglial TLR4 in the hippocampus of AD brain | We recently demonstrated that prothrombin kringle-2 (pKr-2) derived from blood-brain barrier (BBB) disruption could induce hippocampal neurodegeneration and object recognition impairment through neurotoxic inflammatory responses in the five familial Alzheimer's disease mutation (5XFAD) mice. In the present study, we aimed to determine whether pKr-2 induces microglial activation by stimulating toll-like receptor 4 (TLR4) upregulation and examine whether this response contributes to pKr-2-induced neuroinflammatory damage in the hippocampi of mice models. We observed that inflammatory responses induced by pKr-2 administration in the hippocampi of wild-type mice were significantly abrogated in TLR4-deficient mice (TLR4-/-), and caffeine supply or rivaroxaban treatment that inhibits the overexpression of hippocampal pKr-2 reduced TLR4 upregulation in 5XFAD mice, resulting in the inhibition of neuroinflammatory responses. Similar to the expression patterns of pKr-2, TLR4, and the TLR4 transcription factors, PU.1 and p-c-Jun, seen in the postmortem hippocampal tissues of Alzheimer's disease (AD) patients, our results additionally showed the influence of transcriptional regulation on TLR4 expression following pKr-2 expression in triggering the production of neurotoxic inflammatory mediators. Therefore, we conclude that pKr-2 may play a role in initiating upregulation of microglial TLR4, consequently inducing hippocampal neurodegeneration. Furthermore, the control of pKr-2-induced microglial TLR4 could be a useful therapeutic strategy against hippocampal neurodegeneration in AD. | Kim, Sehwan; Sharma, Chanchal; Shin, Minsang; Kim, Hyung-Jun; Kim, Jaekwang; Kim, Sang Ryong | Kyungpook Natl Univ, Sch Life Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41944, South Korea; Kyungpook Natl Univ, BK21 FOUR KNU Creat Biores Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Microbiol, Daegu 41944, South Korea; Korea Brain Res Inst, Dementia Res Grp, Daegu 41068, South Korea | 57193232250; 57193577728; 7401536650; 57191717907; 57201935123; 56486163800 | srk75@knu.ac.kr; | BRAIN, BEHAVIOR, & IMMUNITY - HEALTH | BRAIN BEHAV IMMUN-HL | 2666-3546 | 28 | ESCI | IMMUNOLOGY;NEUROSCIENCES;PSYCHIATRY | 2023 | 3.7 | 22.4 | 0.91 | 2025-06-25 | 4 | 4 | Prothrombin kringle -2; Toll -like receptor 4; Microglia; Hippocampus; Neuroinflammation; Neurodegeneration; Alzheimer's disease | TOLL-LIKE RECEPTORS; IN-VIVO; C-JUN; ALZHEIMERS; PU.1; INFLAMMATION; EXPRESSION; THROMBIN; DISEASE; NEUROINFLAMMATION | Alzheimer's disease; Hippocampus; Microglia; Neurodegeneration; Neuroinflammation; Prothrombin kringle-2; Toll-like receptor 4 | caffeine; protein c jun; prothrombin; rivaroxaban; toll like receptor 4; transcription factor PU 1; 5xFAD mouse; adult; aged; Alzheimer disease; animal cell; animal experiment; animal model; animal tissue; Article; brain damage; brain nerve cell; cell activation; cognitive defect; controlled study; drug effect; female; gene overexpression; hippocampal CA1 region; hippocampal tissue; hippocampus; human; human tissue; kringle domain; male; microglia; molecular pathology; mouse; nerve degeneration; nervous system inflammation; neurotoxicity; nonhuman; novel object recognition test; protein expression; protein function; prothrombin kringle 2; transcription regulation; upregulation | English | 2023 | 2023-03 | 10.1016/j.bbih.2023.100593 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Correction | Prediction of strawberry fruit yield based on cultivar-specific growth models in the tunnel-type greenhouse (vol 63, pg 467, 2022) | Jo, Jung Su; Kim, Dong Sub; Jo, Won Jun; Sim, Ha Seon; Lee, Hye Jin; Moon, Yu Hyun; Woo, Ui Jeong; Jung, Soo Bin; Kim, Steven; Mo, Xiaoming; Ahn, Su Ran; Kim, Sung Kyeom | Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Hort Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea; Kongju Natl Univ, Dept Hort, Yesan 32439, South Korea; Calif State Univ Monterey Bay, Dept Math & Stat, Seaside, CA 93955 USA | Kim, Sung Kyeom/AAD-9230-2019; Kim, Dong/G-7392-2017 | 57197337268; 15760138600; 57219474538; 57220890640; 57900161200; 57226272477; 57226269481; 57474949700; 55243558900; 57222468175; 57220895028; 50262290200 | skkim76@knu.ac.kr; | HORTICULTURE ENVIRONMENT AND BIOTECHNOLOGY | HORTIC ENVIRON BIOTE | 2211-3452 | 2211-3460 | 64 | 3 | SCIE | HORTICULTURE | 2023 | 2.5 | 22.4 | 0 | 2025-06-25 | 0 | 0 | English | 2023 | 2023-06 | 10.1007/s13580-022-00484-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Resilient modulus estimation using in-situ modulus detector: performance and factors | The resilient modulus of subgrade should be estimated for pavement designs that undergo repetitive loading from vehicular movement. In this study, an in-situ modulus detector (IMD) with flat, wedge, and cone tips is employed to estimate the resilient modulus. The specimens with three different levels of water content are compacted, and the dynamic responses for two hammer drop heights are analysed. For all specimens, elastic waves are acquired to estimate the shear modulus and Poisson's ratio using bender and piezo-disk elements. The resilient modulus estimated from the IMD is compared with the lightweight deflectometer (LWD) modulus. The experimental results show a stronger relationship between the flat and wedge tips than between the cone and wedge tips. Furthermore, higher drop heights result in strong relationships between the resilient, shear, and LWD moduli. This study proposes an intrinsic design and verification of an IMD for reliable resilient modulus estimation in pavement design. | Kim, Sang Yeob; Kim, Dong-Ju; Lee, Jong-Sub; Kang, Thomas H-K; Byun, Yong-Hoon | Korea Univ, Sch Civil Environm & Architectural Engn, Seoul, South Korea; Seoul Natl Univ, Dept Architecture & Architectural Engn, Seoul, South Korea; Kyungpook Natl Univ, Sch Agr Civil & Bioind Engn, Daegu, South Korea | Lee, Jong-Sub/G-2752-2012; Byun, Yong-Hoon/JKI-8441-2023; Kang, Thomas/AAP-5210-2020 | 57202787920; 7409760881; 55690048400; 26643496900; 42761048000 | yhbyun@knu.ac.kr; | INTERNATIONAL JOURNAL OF PAVEMENT ENGINEERING | INT J PAVEMENT ENG | 1029-8436 | 1477-268X | 24 | 2 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL;MATERIALS SCIENCE, CHARACTERIZATION & TESTING | 2023 | 3.4 | 22.4 | 0.81 | 2025-06-25 | 8 | 8 | Elastic wave; in-situ test; LWD; resilient modulus; subgrade | RESISTANCE; STRENGTH | Elastic wave; in-situ test; LWD; resilient modulus; subgrade | Drops; Pavements; Shear flow; Deflectometers; Detector performance; Drop height; In-situ test; Lightweight deflectometer; Pavement design; Repetitive loadings; Resilient modulus; S ratio; Subgrade; Elastic waves | English | 2023 | 2023-01-28 | 10.1080/10298436.2022.2096883 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | A multiplexed siRNA screen identifies key kinase signaling networks of brain glia | The dynamic behaviors of brain glial cells in various neuroinflammatory conditions and neurological disorders have been reported; however, little is known about the underlying intracellular signaling pathways. Here, we developed a multiplexed kinome-wide siRNA screen to identify the kinases regulating several inflammatory phenotypes of mouse glial cells in culture, including inflammatory activation, migration, and phagocytosis of glia. Subsequent proof-of-concept experiments involving genetic and pharmacological inhibitions indicated the importance of T-cell receptor signaling components in microglial activation and a metabolic shift from glycolysis to oxidative phosphorylation in astrocyte migration. This time- and cost-effective multiplexed kinome siRNA screen efficiently provides exploitable drug targets and novel insight into the mechanisms underlying the phenotypic regulation of glial cells and neuroinflammation. Moreover, the kinases identified in this screen may be relevant in other inflammatory diseases and cancer, wherein kinases play a critical role in disease signaling pathways. | Kim, Jong-Heon; Han, Jin; Afridi, Ruqayya; Kim, Jae-Hong; Rahman, Md Habibur; Park, Dong Ho; Lee, Won Suk; Song, Gyun Jee; Suk, Kyoungho | Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, Dept Pharmacol, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Ophthalmol, Daegu, South Korea; Neuracle Sci Co Ltd, Seoul, South Korea; Catholic Kwandong Univ, Coll Med, Dept Med Sci, Gangneung Si, South Korea; Catholic Kwandong Univ, Int St Marys Hosp, Translat Brain Res Ctr, Incheon, South Korea; Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD USA | Rahman, Md Habibur/HMD-4572-2023 | 57203324811; 57218360938; 57200759784; 55926599800; 59607139800; 36676632900; 59442639300; 7402253055; 7005114595 | ksuk@knu.ac.kr; | LIFE SCIENCE ALLIANCE | LIFE SCI ALLIANCE | 2575-1077 | 6 | 5 | SCIE | BIOLOGY | 2023 | 3.3 | 22.5 | 0.16 | 2025-06-25 | 1 | 1 | NITRIC-OXIDE; ACTIVATION; ASTROCYTES; EXPRESSION; PATHWAY; ROLES | Animals; Brain; Cell Movement; Mice; Neuroglia; RNA, Small Interfering; Signal Transduction; small interfering RNA; animal; brain; cell motion; genetics; glia; mouse; signal transduction | English | 2023 | 2023-05 | 10.26508/lsa.202201605 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Energy, Exergy and Economic (3E) analysis of evacuated tube heat pipe solar collector to promote storage energy under North African climate | Evacuated tube solar collectors are solar water heating devices known to be technically viable and economically attractive. In contrast, these systems encounter several problems owing to the unavoidable heat and water losses along the manifold, essentially conduction and convection losses. In warm weather, heat pipes become partially filled with water and boil, increasing the need for a pressure vessel. One of the popular strategies used to tackle this technical trouble is integrating Phase Change Materials (PCMs) into the evacuated tube solar collectors. In this paper, this problem was approached with a broader perspective by assembling three collectors technically modified, thermally optimized, and economically profitable. The first configuration presents a normal industrial solar collector (1). While in the second and third configurations, the solar system was improved through several modifications. In the second system, the manifold was re-insulated all around (2). In the third, the manifold was surrounded by PCM filled into a copper cavity (3). To well highlight the performed amendments, a comparative approach between the three vacuum tube heat pipe solar collectors is presented. The established methodology is based on energy and exergy analysis and is supplemented by an economic evaluation. It was found that the energy and exergy efficiencies for the conventional collector were 41 % and 15 % respectively. While the thermal energy performance recorded for the second collector was ranged between 60 % and 80 %. Concerning the third collector with insulation and thermal storage unit, the total solar energy absorbed during a typical day was 39.68 MJ, the total useful energy recuperated during a day was 4.11 MJ and the daily thermal efficiency was 13 %. The efficiency of the improved collector (3) was further improved until 28 MJ of energy storage was recorded of which 4.3 MJ were delivered to the water overnight. Moreover, an economic feasibility study was carried out, in which the economic feasibility for the last new system. showed an amortization period of five years. | Bouadila, Salwa; Rehman, Tauseef-ur; Baig, Maughal Ahmed Ali; Skouri, Safa; Baddadi, Sara | Ctr Rech & Technol Energie, Borj Cedria BP 95, Hamam Lif 2050, Ben Arous, Tunisia; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; CMR Tech Campus, Dept Mech Engn, Hyderabad, India | ; BOUADILA, Salwa/AAP-6218-2020; Rehman, Tauseef-ur/AAE-3086-2022; Baig, Maughal Ahmed Ali/AAF-9768-2020 | 55710749600; 57159403400; 37116375300; 55711209900; 57205263214 | salwa.bouadila@crten.rnrt.tn; | SUSTAINABLE ENERGY TECHNOLOGIES AND ASSESSMENTS | SUSTAIN ENERGY TECHN | 2213-1388 | 2213-1396 | 55 | SCIE | ENERGY & FUELS;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2023 | 7.1 | 22.5 | 2.12 | 2025-06-25 | 20 | 23 | Energy efficiency; Exergy efficiency; ETSC; Latent heat storage; PCM | THERMAL PERFORMANCE; FLAT-PLATE; WATER-HEATER; SYSTEM; EFFICIENCY | Energy efficiency; ETSC; Exergy efficiency; Latent heat storage; PCM | North Africa; Collector efficiency; Economic analysis; Electron tubes; Exergy; Heat pipes; Heat storage; Passive solar; Phase change materials; Solar heating; Solar water heaters; Storage (materials); Thermal insulation; Economic feasibilities; Energy economics; ETSC; Evacuated tube solar collector; Evacuated tubes; Exergy efficiencies; Heat-pipe solar collectors; Latent heat storage; Solar water heating; Storage energy; alternative energy; climate conditions; comparative study; economic analysis; energy efficiency; energy storage; exergy; feasibility study; heat production; heat source; latent heat flux; solar power; Energy efficiency | English | 2023 | 2023-02 | 10.1016/j.seta.2022.102959 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Impact of environmental factors on night-time electricity generation using thermoelectric generator | Nighttime electricity generation (NTEG) using thermoelectric generators (TEGs) and radiative cooling concept is a widely known phenomenon. However, the NTEGs are challenged by low voltage generation. The factors influencing the performance of the NTEGs comprise environmental conditions, such as ambient temperature, wind velocity and relative humidity. However, the effect of these parameters has not been explored. Therefore, the present study aims to experimentally investigate the influence of these variables on the generated power resulting from the temperature difference created between different entities of the NTEG setup by using an inhouse designed facility. The experimental setup consisted of multiple TEGs sandwiched between a radiative plate at the top and an aluminium block attached to a hot plate at the bottom. The tests were performed on various nights to analyse the effect of these parameters. The night with a higher ambient temperature triggered higher temperature difference between the top and bottom surface of the TEGs, resulting in the higher voltage production. Moreover, the same trend was observed for the wind velocity. By contrast, the largest temperature gap between an emitter plate and the surrounding air was recorded on a night with the lowest relative humidity, thereby providing a higher voltage. Furthermore, with various series, parallel and series-parallel configurations, we finally found a combination of commercially available TEGs for NTEG, which can be effectively used for lighting up a three-watt bulb. | Khan, Shahvaiz; Cheema, Taqi Ahmad; Abbas, Ahmad; Ullah, Rizwan; Park, Cheol Woo | GIK Inst Engn Sci & Technol, Fac Mech Engn, Swabi 23460, Pakistan; Kyungpook Natl Univ, Sch Mech Engn, 80 Daehak Ro, Daegu 41566, South Korea | Abbas, Ahmad/GSM-9364-2022 | 57464063800; 36522492600; 57193502684; 57534907400; 7408416474 | tacheema@giki.edu.pk;chwoopark@knu.ac.kr; | SUSTAINABLE ENERGY TECHNOLOGIES AND ASSESSMENTS | SUSTAIN ENERGY TECHN | 2213-1388 | 2213-1396 | 56 | SCIE | ENERGY & FUELS;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2023 | 7.1 | 22.5 | 0.46 | 2025-06-25 | 5 | 5 | Energy harvesting; Thermoelectric generators; Nighttime electricity generation; Open circuit voltage; Temperature difference | PERFORMANCE; ENERGY | Energy harvesting; Nighttime electricity generation; Open circuit voltage; Temperature difference; Thermoelectric generators | Electric generators; Electric power generation; Electronic equipment; Open circuit voltage; Temperature; Thermoelectric equipment; Timing circuits; Wind; Electricity-generation; Environmental factors; High-voltages; Night time; Nighttime electricity generation; Open-circuit voltages; Series-parallel; Temperature differences; Thermoelectric generators; Wind velocities; air temperature; electricity generation; environmental conditions; environmental factor; relative humidity; wind velocity; Energy harvesting | English | 2023 | 2023-03 | 10.1016/j.seta.2022.103000 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Potential Role of Vermicompost in Abiotic Stress Tolerance of Crop Plants: a Review | Abiotic stress is a major component in crop loss worldwide because it can change a plant's physiological processes, making it more vulnerable to viruses and pests while also restricting its ability to survive and thrive. The overuse of chemical fertilizers, insecticides, and herbicides in modern conventional agriculture contributes to major environmental issues such as water contamination, soil salinization and degradation, and biodiversity loss. Therefore, in the future, more sustainable farming practices will be needed to assure food security and production despite such unfavorable environmental conditions. Applying organic fertilizer would be the most effective and environmentally responsible way to attain this goal while addressing environmental issues. Earthworms and microbes work together to break down organic matter to create vermicompost (VC), which is nutrient-rich and microbiologically active. By modifying the physiological, biological, and biochemical processes of the crop plants, vermicompost has the potential to significantly improve plant growth, flowering, crop productivity, nutrient use efficiency (NUE), and translocation, as well as increasing tolerance to a wide range of abiotic stresses. The current research aimed to determine whether vermicompost may help vegetable crops manage abiotic challenges to achieve food security in a sustainable manner. Particular focus was placed on the physiological changes that occur in plants under stressful environmental conditions and how vermicompost plays a vital role in helping plants adapt to these stresses. | Toor, Muhammad Danish; Kizilkaya, Ridvan; Ullah, Izhar; Koleva, Lyubka; Basit, Abdul; Mohamed, Heba I. | Ondokuz Mayis Univ, Fac Agr, Dept Soil Sci & Plant Nutr, Samsun, Turkiye; Ondokuz Mayis Univ, Fac Agr, Dept Hort, Samsun, Turkiye; Agr Univ Plovdiv, Dept Plant Physiol & Biochem, Plovdiv, Bulgaria; Kyungpook Natl Univ, Dept Hort, Daegu 41566, South Korea; Ain Shams Univ, Fac Educ, Dept Biol & Geol Sci, Cairo 1575, Egypt | Basit, Abdul/AAX-2414-2021; mohamed, heba/U-8673-2019; Ullah, izhar/MYR-3437-2025; Koleva, Lyubka/B-4695-2009; Kızılkaya, Rıdvan/AAY-1550-2020 | 57375664400; 9038789000; 57211559793; 6505802976; 57218918852; 37102371200 | hebaibrahim79@gmail.com; | JOURNAL OF SOIL SCIENCE AND PLANT NUTRITION | J SOIL SCI PLANT NUT | 0718-9508 | 0718-9516 | 23 | 4 | SCIE | ENVIRONMENTAL SCIENCES;PLANT SCIENCES;SOIL SCIENCE | 2023 | 3.4 | 22.5 | 0.44 | 2025-06-25 | 7 | 8 | Sustainability; Abiotic stress tolerance; Conventional agriculture; Growth; Yield | HEAT TOLERANCE; MORPHOLOGICAL-CHARACTERISTICS; BIOCHEMICAL RESPONSES; LIPID-PEROXIDATION; METAL AVAILABILITY; MICROBIAL ACTIVITY; EARTHWORM CASTS; ORGANIC WASTES; GLYOXALASE-I; HUMIC ACIDS | Abiotic stress tolerance; Conventional agriculture; Growth; Sustainability; Yield | English | 2023 | 2023-12 | 10.1007/s42729-023-01476-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Correlation between the Structural Variations in Thiol-Based Hardeners and Properties of Thiol-Epoxy Polymers | Epoxy-based elastomers with remarkable flexibility have garnered attention due to their versatility in various applications, including sensors, smart fabrics, nanocomposites, and thermally conductive composite materials. In these studies, the selection of an appropriate hardener is crucial to imparting elastomeric properties to epoxy. Among the various available hardeners, thiol-based hardeners present notable advantages. First, they facilitate rapid curing at low temperatures via an epoxy-thiol click reaction. Second, the flexibility of the C-S bonds enables glass transition near room temperature. Despite these merits, the utilization of thiol-based hardeners in epoxy elastomer materials remains limited, primarily due to the lack of a well-established structure-property relationship between the thiol hardeners and epoxy elastomers. In this study, we carefully examined the effect of the hardener structure on the properties of thiol-epoxy polymers. While maintaining the structure of a tetrafunctional thiol as a cross-linker, we varied the structure of a bifunctional thiol to analyze its influence on the physical properties of the resulting thiol-epoxy material. Factors such as the presence or absence of an oxygen atom, the existence of a ring structure, the presence or absence of aromatics, and the geometric shape of the hardener all influenced the mechanical properties, such as modulus, stress, and toughness. Notably, the structure of the bifunctional hardener allowed precise control over the glass transition temperature of the thiol-epoxy material near room temperature, resulting in distinct mechanical behaviors (elastic or plastic) at room temperature. Based on these findings, we successfully developed a thiol-epoxy material exhibiting elastomeric behavior at room temperature and shape memory characteristics at temperatures close to room temperature (e.g., 40 C-degrees). | Kim, Daewhan; Yu, Changhoon; Kwon, Yonghwan; Kim, Jinju; Chung, Kyeongwoon; Kim, Hyun-Joong; Kwon, Min Sang | Seoul Natl Univ, Dept Mat Sci & Engn, Seoul 08826, South Korea; Seoul Natl Univ, Dept Res Inst Adv Mat, Seoul 08826, South Korea; Kyungpook Natl Univ, Dept Biofibers & Biomat Sci, Daegu 41566, South Korea; Seoul Natl Univ, Dept Agr Forestry & Bioresources, Seoul 08826, South Korea | Lee, Chung Whan/AAK-8902-2020; Kwon, Min Sang/LSM-1406-2024; Kwon, Min Sang/I-5237-2015 | 55820312900; 57204195212; 57204198742; 57827237700; 56416916000; 55739607300; 7103153987 | minsang@snu.ac.kr; | ACS APPLIED POLYMER MATERIALS | ACS APPL POLYM MATER | 2637-6105 | 5 | 11 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;POLYMER SCIENCE | 2023 | 4.5 | 22.6 | 0.94 | 2025-06-25 | 9 | 8 | thiol-epoxy polymer; thiol hardener; thiol-epoxy click reaction; epoxy elastomers; shape memory polymers | CONDUCTIVE ADHESIVES; MECHANICAL-PROPERTIES; COMPOSITES; NETWORKS; ELASTOMERS; RESISTANCE; BEHAVIOR; RESINS | epoxy elastomers; shape memory polymers; thiol hardener; thiol-epoxy click reaction; thiol-epoxy polymer | Conductive materials; Glass; Glass transition; Plastics; Room temperature; Structural properties; Toughness; Click reaction; Epoxy; Epoxy elastomer; Epoxy material; Epoxy polymers; Shape memory polymers; Thiol hardener; Thiol-epoxy click reaction; Thiol-epoxy polymer; Elastomers | English | 2023 | 2023-10-10 | 10.1021/acsapm.3c01502 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Improvement of modified maximum force criterion for forming limit diagram prediction of sheet metal | This study presents a new criterion (MMFC2) for predicting the forming limit curve (FLC) of sheet metal. The strain path evolution of a critical element examined in a uniaxial tensile test is elaborated by incorporating the results of experimental measurement, finite element simulation, and theoretical prediction via the Modified Maximum Force Criterion (MMFC). A scaling factor is introduced to mimic the theoretical evaluation with the simulated one. It is believed that the rotation of the principal axes of the theoretically considering material point, which is initially co-axial with the external load coordinate, implicates the macro track of the strain path change. Furthermore, an optimal event of the second derivative of the axial rotations is proposed to indicate the strain localization and formulate the FLC. The performance of the proposed criterion is compared with that of the original MMFC in predicting the FLC of three automotive sheet metals, of which all related data were published in the Benchmark of Numisheet 2014 conference. The use of three different hardening laws and three yield functions is examined in the analogy. The comparison reveals that the results of MMFC2 are more sensitive to the employed constitutive model than that of MMFC. Furthermore, the proposed MMFC2 presents concordant results with the experimental data. Nakajima tests are conducted for CR4 mild steel sheets to validate the capacity of the proposed criterion. Well agreement between the experimentally measured data and theoretical prediction based on the Yld2k yield function verifies its usefulness in practice. | Pham, Quoc Tuan; Islam, Md Shafiqul; Sigvant, Mats; Caro, Lluis Perez; Lee, Myoung-Gyu; Kim, Young-Suk | Blekinge Inst Technol, Dept Mech Engn, Karlskrona, Sweden; Volvo Cars, S-81110 Olofstrom, Sweden; RISE Res Inst Sweden, Component Mfg Unit, Olofstrom, Sweden; Seoul Natl Univ, Dept Mat Sci & Engn, Seoul 08826, South Korea; Seoul Natl Univ, RIAM, Seoul 08826, South Korea; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea | Islam, Md Shafiqul/AEN-7201-2022; Pérez, Lluís/J-3217-2014; Pham, Tuan/AAH-8010-2019; Sigvant, Mats/JJG-2577-2023; Perez Caro, Lluis/J-3217-2014; Pham, Quoc Tuan/AAH-8010-2019 | 57191753992; 57198634262; 6505768006; 57204050474; 26323686000; 36065820800 | quoc.tuan.pham@bth.se; | INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES | INT J SOLIDS STRUCT | 0020-7683 | 1879-2146 | 273 | SCIE | MECHANICS | 2023 | 3.4 | 22.6 | 1.28 | 2025-06-25 | 9 | 9 | Forming limit diagram; Modified maximum force criterion; Sheet metal; Diffuse neck; Localized neck | THICKNESS NORMAL STRESS; LOCALIZED NECKING; BIFURCATION-ANALYSIS; ALUMINUM-ALLOY; HARDENING LAW; STRAIN-RATE; CURVES; MODEL; STEEL; TEMPERATURE | Diffuse neck; Forming limit diagram; Localized neck; Modified maximum force criterion; Sheet metal | Benchmarking; Sheet metal; Tensile testing; Diffuse neck; Forming limit curve; Forming limit diagrams; Localised; Localized neck; Maximum forces; Modified maximum force criteria; Path evolutions; Strain paths; Yield function; Forecasting | English | 2023 | 2023-06-15 | 10.1016/j.ijsolstr.2023.112264 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Temperature-Invariant Large Broadband Polyimide Dielectrics with Multimodal Porous Networks | Herein, we describe sponge-like polymeric materials withmultimodalporous networks with stable ultralow dielectric properties over broadfrequency and temperature ranges. A hierarchically porous polyimide(PI) film was prepared via nonsolvent-induced phase separation (NIPS),followed by stepwise thermal imidization. Through the swelling andthe subsequent liquid-liquid phase separation, highly insulatinginterconnected pores of the internal layer and the water-vapor impermeable,closed-cell skin of the outer layer were directly formed on the PIfilm. The grafting of porous PI onto amino-functionalized mesoporoussilica (AMS) to further adjust the overall thermal stability and dielectricconstant has become a valid strategy. The porous PI-grafted-AMS (PPI-g-AMS) exhibited uniform micropores, which were regularlyshaped with an average diameter of 16.3 +/- 0.6 mu m. The glasstransition temperature (T (g)) of PPI-g-AMS increased considerably from 367 degrees C to as highas 398 degrees C because of the formation of interchain cross-linkingbridges in the AMS. Outstanding dielectric constant (D (k)) and dissipation factor (D (f)) of 1.84 and 0.0018 at a frequency of 1 MHz, respectively, wereachieved for PPI-g-AMS-1 with the addition of AMSwith 1% wt. Moreover, stable and ultralow D (k) (similar to 1.84 at 1 MHz) and D (f) (similar to 0.001at 1 MHz) values were achieved over a broad temperature range from-20 to 200 degrees C. These findings indicate the broad applicationpotential of polymeric materials as interlevel insulation materialsin the next-generation 5G/6G infrastructure. | Khim, Seongjun; Hwang, Yun Chan; Choi, Jaewon; Park, Hyunjin; Nam, Ki-Ho | Kyungpook Natl Univ, Dept Text Syst Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Polymer Sci & Engn, Daegu 41566, South Korea; Korea Res Inst Chem Technol KRICT, Chem Mat Solut Ctr, Daejeon 34114, South Korea | ; Park, Hyunjin/D-1435-2019 | 58024968200; 58302885000; 57210206972; 57198844143; 55553181500 | knam@knu.ac.kr; | ACS APPLIED POLYMER MATERIALS | ACS APPL POLYM MATER | 2637-6105 | 5 | 6 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;POLYMER SCIENCE | 2023 | 4.5 | 22.6 | 2.15 | 2025-06-25 | 13 | 16 | polyimides; low-k dielectrics; nonsolvent-inducedphase separation; molecular sieve; multimodal porousnetworks | INDUCED PHASE-SEPARATION; POLYMER NANOCOMPOSITES; POROSITY MEASUREMENT; FILMS; CONSTANT; MORPHOLOGY; MEMBRANES | low-k dielectrics; molecular sieve; multimodal porous networks; nonsolvent-induced phase separation; polyimides | Glass transition; Grafting (chemical); Molecular sieves; Phase separation; Polyimides; Silica; Swelling; Amino-functionalized mesoporous silicas; Broad temperature ranges; Dissipation factors; Low- k dielectrics; Multi-modal; Multimodal porous network; Nonsolvent-induced phase separation; Polyimide film; Porous networks; Ultra-low dielectric; Low-k dielectric | English | 2023 | 2023-05-12 | 10.1021/acsapm.3c00369 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Antimicrobial activity of a-mangostin against Staphylococcus species from companion animals in vitro and therapeutic potential of a-mangostin in skin diseases caused by S. pseudintermedius | Antimicrobial resistance in Staphylococcus species from companion animals is becoming increasingly prevalent worldwide. S. pseudintermedius is a leading cause of skin infections in companion animals. a-mangostin (a-MG) exhibits various pharmacological activities, including antimicrobial activity against G (+) bacteria. This study investigated the antimicrobial activity of a-MG against clinical isolates of Staphylococcus species from companion animals and assessed the therapeutic potential of a-MG in skin diseases induced by S. pseudintermedius in a murine model. Furthermore, the action mechanisms of a-MG against S. pseudintermedius were investigated. a-MG exhibited antimicrobial activity against clinical isolates of five different Staphylococcus species from skin diseases of companion animals in vitro, but not G (-) bacteria. a-MG specifically interacted with the major histocompatibility complex II analogous protein (MAP) domain-containing protein located in the cytoplasmic membrane of S. pseudintermedius via hydroxyl groups at C-3 and C-6. Pretreatment of S. pseudintermedius with anti-MAP domain-containing protein polyclonal serum significantly reduced the antimicrobial activity of a-MG. The sub-minimum inhibitory concentration of a-MG differentially regulated 194 genes, especially metabolic pathway and virulence determinants, in S. pseudintermedius. a-MG in pluronic lecithin organogel significantly reduced the bacterial number, partially restored the epidermal barrier, and suppressed the expression of cytokine genes associated with pro-inflammatory, Th1, Th2, and Th17 in skin lesions induced by S. pseudintermedius in a murine model. Thus, a-MG is a potential therapeutic candidate for treating skin diseases caused by Staphylococcus species in companion animals. | Park, Seong Yong; Lee, Jung Hwa; Ko, Seo Yeon; Kim, Nayeong; Kim, Seong Yeop; Lee, Je Chul | Kyungpook Natl Univ, Sch Med, Dept Microbiol, Daegu, South Korea | 57958559800; 58303148700; 57959870800; 57211500281; 59782772500; 25930392000 | leejc@knu.ac.kr; | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | FRONT CELL INFECT MI | 2235-2988 | 13 | SCIE | IMMUNOLOGY;MICROBIOLOGY | 2023 | 4.6 | 22.7 | 2.16 | 2025-06-25 | 13 | 13 | Staphylococcus species; companion animals; alpha-Mangostin; antimicrobial activity; MAP domain-containing protein | GARCINIA-MANGOSTANA; ALPHA-MANGOSTIN; ANTIBACTERIAL ACTIVITY; BACTERICIDAL ACTIVITY; MAP PROTEIN; AUREUS; XANTHONES; INFLAMMATION; MRSA | antimicrobial activity; companion animals; MAP domain-containing protein; Staphylococcus species; α-Mangostin | Animals; Anti-Infective Agents; Disease Models, Animal; Membrane Proteins; Mice; Pets; Skin Diseases; Staphylococcus; alpha mangostin; bacterial protein; DNA polymerase; gamma interferon; genomic DNA; interleukin 13; interleukin 17; interleukin 1beta; major histocompatibility antigen class 2; tumor necrosis factor; unclassified drug; xanthone derivative; antiinfective agent; mangostin; membrane protein; amino acid sequence; animal experiment; animal model; animal tissue; antibiotic sensitivity; antimicrobial activity; Article; bacterial metabolism; bacterial strain; bacterial virulence; bactericidal activity; bacterium culture; bacterium isolate; biotinylation; cell culture; cell lysate; cell membrane; chemical structure; colony forming unit; controlled study; cytotoxicity; cytotoxicity assay; DNA sequencing; Escherichia coli; female; field emission scanning electron microscopy; gene control; gene expression; histology; in vitro study; liquid chromatography-mass spectrometry; major histocompatibility complex; membrane vesicle; minimum bactericidal concentration; minimum inhibitory concentration; mouse; murine; nonhuman; pet animal; polyacrylamide gel electrophoresis; protein domain; proton nuclear magnetic resonance; Pseudomonas aeruginosa; pull-down assay; quadrupole mass spectrometry; real time polymerase chain reaction; RNA extraction; skin defect; staphylococcal skin infection; Staphylococcus aureus; Staphylococcus epidermidis; Staphylococcus pseudintermedius; Staphylococcus schleiferi; Th1 cell; Th17 cell; Th2 cell; ultrasound; animal; disease model; skin disease; Staphylococcus | English | 2023 | 2023-05-25 | 10.3389/fcimb.2023.1203663 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Association of changes in body mass index and waist circumference with cardiovascular risk in non-alcoholic fatty liver disease: A nationwide study | Background: We investigated whether changes in body mass index (BMI) and waist circumference (WC) are associated with cardiovascular risk in patients with NAFLD using a nationwide dataset. Methods: Using the National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) data in Korea, a total of 19,057 subjects who underwent two consecutive medical check-ups (2009-2010 and 2011- 2012) and who had a fatty-liver index (FLI) value of >= 60 were included in the analysis. Cardiovascular events were defined as the occurrence of stroke or transient ischemic attack, coronary heart disease, and cardiovascular death. Results: After multivariable adjustment, the risk of cardiovascular events was significantly lower in subjects with decreases in both BMI and WC (HR, 0.83; 95% CI, 0.69-0.99) and those with increased BMI and decreased WC (HR, 0.74; 95% CI, 0.59-0.94) when compared with those who showed increases in both BMI and WC. The effect of cardiovascular risk reduction among the group with increased BMI but decreased WC was particulary pronounced among those who had metabolic syndrome during the second check-up (HR, 0.63; 95% CI 0.43-0.93, p for interaction 0.02). Conclusions: Changes in BMI and WC were significantly associated with cardiovascular risk in NAFLD patients. NAFLD patients with increased BMI and decreased WC had the lowest cardiometabolic risk. (c) 2023 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. | Jang, Se Young; Kim, Hwa Jung; Chang, Jun Young | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Div Gastroenterol & Hepatol, Dept Internal Med,Sch Med, Daegu, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Clin Epidemiol & Biostat, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Neurol, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea | 57202881977; 57049824100; 56346807100 | noyerpapa@amc.seoul.kr; | DIGESTIVE AND LIVER DISEASE | DIGEST LIVER DIS | 1590-8658 | 1878-3562 | 55 | 11 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 4 | 22.7 | 0.29 | 2025-06-25 | 3 | 2 | Body mass index; Cardiovascular diseases; Non-alcoholic fatty liver disease; Waist circumference | THIGH FAT; MORTALITY; INDIVIDUALS; MUSCLE; NAFLD | Body mass index; Cardiovascular diseases; Non-alcoholic fatty liver disease; Waist circumference | Body Mass Index; Cardiovascular Diseases; Heart Disease Risk Factors; Humans; Non-alcoholic Fatty Liver Disease; Risk Factors; Waist Circumference; adult; Article; body mass; cardiovascular mortality; cardiovascular risk; cerebrovascular accident; cohort analysis; controlled study; fatty liver index; female; human; ischemic heart disease; Korea; major clinical study; male; mass screening; medical examination; metabolic syndrome X; middle aged; national health insurance; nonalcoholic fatty liver; risk assessment; risk reduction; transient ischemic attack; waist circumference; body mass; cardiovascular disease; complication; heart disease risk factor; nonalcoholic fatty liver; risk factor; waist circumference | English | 2023 | 2023-11 | 10.1016/j.dld.2023.06.006 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Crystal growth, luminescence, and scintillation properties of Zn2Te3O8 crystal for 0νββ decay search | A single crystal of Zn2Te3O8 (ZTO) was grown using the conventional Czochralski technique. TGA analysis showed that the melting point of ZTO is 681 °C, while it exhibits a structural phase transition at 621 °C. The powder X-ray diffraction analysis of ZTO confirmed that it possesses a single crystalline monoclinic structure with the C2/c space group. An indirect band gap of 3.75 eV was estimated for the ZTO crystal based on its absorption spectrum. The X-ray-induced luminescence of the grown crystal comprised a broad band peaking at 565 nm, which can be tentatively assigned to the self-trapped exciton emission from the (Te3O8)4− molecular complexes. The photoluminescence measured under 280 nm excitation showed a broad band luminescence peaking at about 600 nm, and its intensity was significantly enhanced upon cooling the crystal from 300 K to 10 K. The photoluminescence decay time under 280 nm excitation was shown to have two exponential components in the range from 10 K to 175 K, which became a single exponential upon further heating the crystal. Low scintillation light was observed at room temperature both under α- and β-particle excitations from 241Am and 90Sr sources, respectively. The scintillation light yield measured under β-particle excitation from the 90Sr source was enhanced by about five orders of magnitude at 10 K in comparison to that at 300 K. The scintillation light yield measured at 10 K under the same experimental conditions for ZTO in comparison with the well-known cryogenic scintillator Li2MoO4 (LMO) was shown to have four times higher scintillation light. A single-crystal ingot of ZTO was obtained for the first time; however, it had several cracks due to its phase transition. Notably, scintillation at low temperatures for a Te-based crystal was observed for the first time. These preliminary findings are very promising and show that ZTO will be a good candidate for cryogenic phonon scintillation detectors for the 0νββ decay search of 130Te. © 2024 The Royal Society of Chemistry. | Khan, Arshad; Kim, H.J.; Kim, Yeongduk; Lee, Moo Hyun; Abdalla, Ayman M.; Algethami, Jari S. | Department of Physics, Faculty of Arts and Sciences, Najran University, Najran, Saudi Arabia, Promising Centre for Sensors and Electronic Devices (PCSED), Najran University, P.O. Box: 1988, Najran, 11001, Saudi Arabia; Department of Physics, Kyungpook National University, Daegu, 41566, South Korea; Center for Underground Physics, Institute for Basic Science (IBS), Daejeon, 34126, South Korea, IBS school, University of Science and Technology (UST), Daejeon, 34113, South Korea; Center for Underground Physics, Institute for Basic Science (IBS), Daejeon, 34126, South Korea, IBS school, University of Science and Technology (UST), Daejeon, 34113, South Korea; Department of Physics, Faculty of Arts and Sciences, Najran University, Najran, Saudi Arabia, Promising Centre for Sensors and Electronic Devices (PCSED), Najran University, P.O. Box: 1988, Najran, 11001, Saudi Arabia; Promising Centre for Sensors and Electronic Devices (PCSED), Najran University, P.O. Box: 1988, Najran, 11001, Saudi Arabia, Department of Chemistry, College of Science and Arts, Najran University, Najran, 11001, Saudi Arabia | 56017063700; 59051568100; 7410207253; 57198252980; 36450112500; 57218215024 | hongjoo@knu.ac.kr; | CrystEngComm | CRYSTENGCOMM | N/A | 1466-8033 | 26 | 2 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;CRYSTALLOGRAPHY | 2023 | 2.6 | 22.7 | 0 | 2025-06-25 | 0 | Absorption spectroscopy; Chromium compounds; Cryogenics; Crystal growth; Energy gap; Excitons; Lithium compounds; Photoluminescence; Scintillation; Tellurium compounds; Tungsten compounds; X ray powder diffraction; Zinc compounds; Broad bands; Czochralski technique; Growth properties; Luminescence properties; Particle excitations; Scintillation light; Scintillation light yield; Scintillation properties; Single-crystalline; Structural phase transition; Single crystals | English | Final | 2023 | 10.1039/d3ce01032e | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Review | Diversity, Lifestyle, Genomics, and Their Functional Role of Cochliobolus, Bipolaris, and Curvularia Species in Environmental Remediation and Plant Growth Promotion under Biotic and Abiotic Stressors | Cochliobolus, Bipolaris, and Curvularia genera contain various devastating plant pathogens that cause severe crop losses worldwide. The species belonging to these genera also perform a variety of diverse functions, including the remediation of environmental contaminations, beneficial phytohormone production, and maintaining their lifestyle as epiphytes, endophytes, and saprophytes. Recent research has revealed that despite their pathogenic nature, these fungi also play an intriguing role in agriculture. They act as phosphate solubilizers and produce phytohormones, such as indole acetic acid (IAA) and gibberellic acid (GAs), to accelerate the growth of various plants. Some species have also been reported to play a significant role in plant growth promotion during abiotic stresses, such as salinity stress, drought stress, heat stress, and heavy metal stress, as well as act as a biocontrol agent and a potential mycoherbicide. Similarly, these species have been reported in numerous industrial applications to produce different types of secondary metabolites and biotechnological products and possess a variety of biological properties, such as antibacterial, antileishmanial, cytotoxic, phytotoxic, and antioxidant activities. Additionally, some of the species have been utilized in the production of numerous valuable industrial enzymes and biotransformation, which has an impact on the growth of crops all over the world. However, the current literature is dispersed, and some of the key areas, such as taxonomy, phylogeny, genome sequencing, phytohormonal analysis, and diversity, are still being neglected in terms of the elucidation of its mechanisms, plant growth promotion, stress tolerance, and bioremediation. In this review, we highlighted the potential role, function, and diversity of Cochliobolus, Curvularia, and Bipolaris for improved utilization during environmental biotechnology. | Khan, Nasir Ali; Asaf, Sajjad; Ahmad, Waqar; Jan, Rahmatullah; Bilal, Saqib; Khan, Ibrahim; Khan, Abdul Latif; Kim, Kyung-Min; Al-Harrasi, Ahmed | Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa 616, Oman; Texas Tech Univ, Inst Genom Crop Abiot Stress Tolerance, Dept Plant & Soil Sci, Lubbock, TX 79409 USA; Univ Houston, Dept Engn Technol, Sugar Land, TX 77479 USA; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea | ; Asaf, Sajjad/ABA-3647-2021; Khan, Abdul/B-1005-2010; Khan, Ibrahim/JMC-5061-2023; Khan, Abdul/H-5910-2011; Jan, Rahmatullah/AIC-3439-2022; Kim, Kyung-Min Kim/C-7007-2014; Ul-Hamid, Anwar/B-7297-2015 | 57320375300; 56595059900; 59054664000; 57201981969; 57031617400; 57191379139; 26639372800; 34868260300; 6506093146 | kkm@knu.ac.kr;aharrasi@unizwa.edu.om; | JOURNAL OF FUNGI | J FUNGI | 2309-608X | 9 | 2 | SCIE | MICROBIOLOGY;MYCOLOGY | 2023 | 4.2 | 22.7 | 1.03 | 2025-06-25 | 15 | 17 | Curvularia; Bipolaris; fungi; phytohormones; abiotic stress; biocontrol; enzymes; bioremediation; diverse role | ENDOPHYTIC FUNGI; BIOLOGICAL-CONTROL; PHOSPHATE SOLUBILIZATION; ANTIMICROBIAL EVALUATION; PHYTOPATHOGENIC FUNGUS; AIRBORNE FUNGAL; SAPROBIC FUNGI; WESTERN-GHATS; LEAF-BLIGHT; CELL-DEATH | abiotic stress; biocontrol; bioremediation; Bipolaris; Curvularia; diverse role; enzymes; fungi; phytohormones | English | 2023 | 2023-02 | 10.3390/jof9020254 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effectiveness of regdanvimab treatment for SARS-CoV-2 delta variant, which exhibited decreased in vitro activity: a nationwide real-world multicenter cohort study | BackgroundImmune-evading severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are emerging continuously. The clinical effectiveness of monoclonal antibody agents that exhibit decreased in vitro activity against SARS-CoV-2 variants needs to be elucidated. MethodsA nationwide, multicenter, retrospective cohort study was designed to evaluate the effectiveness of regdanvimab, an anti-SARS-CoV-2 monoclonal antibody agent. Regdanvimab was prescribed in South Korea before and after the emergence of the delta variant, against which the in vitro activity of regdanvimab was decreased but present. Mild to moderate coronavirus 2019 (COVID-19) patients with risk factors for disease progression who were admitted within seven days of symptom onset were screened in four designated hospitals between December 2020 and September 2021. The primary outcomes, O-2 requirements and progression to severe disease within 21 days of admission, were compared between the regdanvimab and supportive care groups, with a subgroup analysis of delta variant-confirmed patients. ResultsA total of 2,214 mild to moderate COVID-19 patients were included, of whom 1,095 (49.5%) received regdanvimab treatment. In the analysis of the total cohort, significantly fewer patients in the regdanvimab group than the supportive care group required O-2 support (18.4% vs. 27.1%, P < 0.001) and progressed to severe disease (4.0% vs. 8.0%, P < 0.001). In the multivariable analysis, regdanvimab was significantly associated with a decreased risk for O-2 support (HR 0.677, 95% CI 0.561-0.816) and progression to severe disease (HR 0.489, 95% CI 0.337-0.709). Among the 939 delta-confirmed patients, O-2 support (21.5% vs. 23.5%, P = 0.526) and progression to severe disease (4.2% vs. 7.3%, P = 0.055) did not differ significantly between the regdanvimab and supportive care groups. In the multivariable analyses, regdanvimab treatment was not significantly associated with a decreased risk for O-2 support (HR 0.963, 95% CI 0.697-1.329) or progression to severe disease (HR 0.665, 95% CI 0.349-1.268) in delta-confirmed group. ConclusionsRegdanvimab treatment effectively reduced progression to severe disease in the overall study population, but did not show significant effectiveness in the delta-confirmed patients. The effectiveness of dose increment of monoclonal antibody agents should be evaluated for variant strains exhibiting reduced susceptibility. | Kim, Haein; Jang, Young Rock; Lee, Ji Yeon; Ko, Jae-Hoon; Lee, Jee Young; Cho, Seongcheol; Lee, Yong Dae; Song, Junghoon; Hyun, Miri; Kim, Hyun Ah; Hwang, Soyoon; Ryou, Sangmi; Na, Yoo Jin; Lee, Joo-Yeon; Lee, Changhee; Lee, Nan Young; Shin, Seunghwan; Kwon, Ki Tae; Kim, Jin Yong; Peck, Kyong Ran | Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Div Infect Dis,Sch Med, Seoul, South Korea; Incheon Med Ctr, Dept Internal Med, Div Infect Dis, Incheon, South Korea; Keimyung Univ, Sch Med, Dept Internal Med, Div Infect Dis,Dongsan Hosp, Daegu, South Korea; Seoul Red Cross Hosp, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med,Div Infect Dis, Daegu, South Korea; Korea Natl Inst Hlth, Ctr Emerging Virus Res, Korea Dis Control & Prevent Agcy, Cheongju, South Korea; Gyeongsang Natl Univ, Coll Vet Med, Jinju, South Korea; Gyeongsang Natl Univ, Virus Vaccine Res Ctr, Jinju, South Korea; Kyungpook Natl Univ, Sch Med, Dept Clin Pathol, Daegu, South Korea; Chung Ang Univ Hosp, Dept Internal Med, Div Infect Dis, Seoul, South Korea; Konkuk Univ, Dept Internal Med, Div Nephrol, Med Ctr, Seoul, South Korea; Lunit Inc, Seoul, South Korea | Kim, Jung/L-9791-2019; LEE, YONGSEOK/AAF-3965-2020; Kim, Hanjin/KYP-2633-2024; Peck, Kyong Ran/AGV-5205-2022 | 57218129617; 57192212402; 57216774221; 55804188300; 57369135600; 56965894600; 57369678400; 57205474026; 55927698200; 57059615500; 57203160675; 57212327522; 57942650500; 7601455784; 55700560700; 57209204358; 56504330800; 9733850500; 57211142178; 55664295200 | sshhissh@gmail.com;ktkwon@knu.ac.kr;kjykey@gmail.com;krpeck@skku.edu; | FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | FRONT CELL INFECT MI | 2235-2988 | 13 | SCIE | IMMUNOLOGY;MICROBIOLOGY | 2023 | 4.6 | 22.7 | 0.66 | 2025-06-25 | 4 | 4 | SARS-CoV-2; delta variant; regdanvimab; monoclonal antibody; outcome | delta variant; monoclonal antibody; outcome; regdanvimab; SARS-CoV-2 | Antibodies, Monoclonal; Antibodies, Viral; COVID-19; Humans; Retrospective Studies; SARS-CoV-2; SARS-CoV-2 variants; ad 26 cov 2 s; albumin; antibiotic agent; bnt 162 b 2; C reactive protein; creatine kinase; elasomeran; ibacovavec; lactate dehydrogenase; mrna 1273; regdanvimab; remdesivir; steroid; tozinameran; vaxzevria; monoclonal antibody; regdanvimab; virus antibody; aged; Article; cohort analysis; controlled study; coronavirus disease 2019; diabetes mellitus; disease exacerbation; disease severity; drug efficacy; female; hospital admission; human; hypertension; in vitro study; lymphocytopenia; male; multicenter study (topic); multiplex real time polymerase chain reaction; neutrophil count; neutrophilia; observational study; progression free survival; real time reverse transcription polymerase chain reaction; retrospective study; risk factor; SARS-CoV-2 Delta; thrombocytopenia; treatment outcome; vaccination; virus load; whole genome sequencing; clinical trial; coronavirus disease 2019; genetics; multicenter study; Severe acute respiratory syndrome coronavirus 2 | English | 2023 | 2023-05-15 | 10.3389/fcimb.2023.1192512 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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