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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Review | Deep Neural Network Models for Colon Cancer Screening | Simple Summary Deep learning models have been shown to achieve high performance in diagnosing colon cancer compared to conventional image processing and hand-crafted machine learning methods. Hence, several studies have focused on developing hybrid learning, end-to-end, and transfer learning techniques to reduce manual interaction and for labelling the regions of interest. However, these weak learning techniques do not always provide a clear diagnosis. Therefore, it is necessary to develop a clear explainable learning method that can highlight factors and form the basis of clinical decisions. However, there has been little research carried out employing such transparent approaches. This study discussed the aforementioned models for colon cancer diagnosis. Early detection of colorectal cancer can significantly facilitate clinicians' decision-making and reduce their workload. This can be achieved using automatic systems with endoscopic and histological images. Recently, the success of deep learning has motivated the development of image- and video-based polyp identification and segmentation. Currently, most diagnostic colonoscopy rooms utilize artificial intelligence methods that are considered to perform well in predicting invasive cancer. Convolutional neural network-based architectures, together with image patches and preprocesses are often widely used. Furthermore, learning transfer and end-to-end learning techniques have been adopted for detection and localization tasks, which improve accuracy and reduce user dependence with limited datasets. However, explainable deep networks that provide transparency, interpretability, reliability, and fairness in clinical diagnostics are preferred. In this review, we summarize the latest advances in such models, with or without transparency, for the prediction of colorectal cancer and also address the knowledge gap in the upcoming technology. | Kavitha, Muthu Subash; Gangadaran, Prakash; Jackson, Aurelia; Maran, Balu Alagar Venmathi; Kurita, Takio; Ahn, Byeong-Cheol | Nagasaki Univ, Sch Informat & Data Sci, Nagasaki 8528521, Japan; Kyungpook Natl Univ, Sch Med, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Univ Malaysia Sabah, Borneo Marine Res Inst, Kota Kinabalu 88400, Sabah, Malaysia; Hiroshima Univ, Grad Sch Adv Sci & Engn, Higashihiroshima 7398521, Japan | Kurita, Takio/D-8674-2012; Kavitha, M.S./AAI-6438-2020; Gangadaran, Prakash/AAV-3102-2021; Venmathi Maran, Balu Alagar/G-5163-2014 | 57218147465; 54393130400; 57859033900; 58789989400; 7201523114; 7202791511 | kavitha@nagasaki-u.ac.jp;prakashg@knu.ac.kr;aureliajcksn@gmail.com;baymaran@ums.edu.my;tkurita@hiroshima-u.ac.jp;abc2000@knu.ac.kr; | CANCERS | CANCERS | 2072-6694 | 14 | 15 | SCIE | ONCOLOGY | 2022 | 5.2 | 29.7 | 1.18 | 2025-06-25 | 21 | 30 | artificial intelligence; colorectal cancer; interpretation; neural network; transfer learning; transparency | COMPUTER-AIDED DIAGNOSIS; COLORECTAL LESIONS; POLYPS; CLASSIFICATION; METASTASIS; SYSTEM; COLONOSCOPY; PREDICTION; CARCINOMA; HISTOLOGY | artificial intelligence; colorectal cancer; interpretation; neural network; transfer learning; transparency | artificial intelligence; attitude to health; biotechnology; cancer diagnosis; cancer localization; cancer screening; clinical decision making; colon cancer; colonoscopy; convolutional neural network; deep neural network; diagnostic accuracy; diagnostic procedure; human; image processing; learning; prediction; Review; transfer of learning | English | 2022 | 2022-08 | 10.3390/cancers14153707 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effects of Low-Frequency Vibrations on Single Point Incremental Sheet Forming | This study investigated the effects of longitudinal low-frequency vibrations on the performance of the single point incremental forming process of an aluminum alloy 1050 (AA1050) sheet. Low-frequency vibrations were added to the forming tool's axial movement. A finite element model of low-frequency vibration single point incremental forming was established. Numerical simulation analyzed the effect of low-frequency vibrations on the entire forming process. Then, the simulation results were verified through actual experiments. The results showed that low-frequency vibrations could significantly reduce the forming force and improve the formed product's geometric accuracy. | Xiao, Xiao; Oh, Se-Hyeon; Kim, Sang-Hoon; Kim, Young-Suk | Kyungpook Natl Univ, Grad Sch, Daegu 41566, South Korea; Hwashin Co Ltd, Eonhagongdan 1 Gil, Yeongcheon Si 38828, South Korea; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea | ; Kim, Sang-Hoon/AAA-2248-2020 | 57195394085; 57452093300; 57188627890; 36065820800 | xiaoye012512@knu.ac.kr;sehyeon3642@knu.ac.kr;sang-hoon.kim@hwashin.co.kr;caekim@knu.ac.kr; | METALS | METALS-BASEL | 2075-4701 | 12 | 2 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2022 | 2.9 | 29.7 | 0.5 | 2025-06-25 | 6 | 6 | incremental sheet forming; low-frequency vibration; forming force; geometric accuracy | LIMIT CURVE; REDUCTION; FORCE; FRICTION; IMPROVEMENT; PRECISION; EXTRUSION; LOAD | Forming force; Geometric accuracy; Incremental sheet forming; Low-frequency vibration | English | 2022 | 2022-02 | 10.3390/met12020346 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Efficacy and Optimal Pressure of Continuous Positive Airway Pressure in Intensity-Modulated Radiotherapy for Locally Advanced Lung Cancer | Simple Summary Radiation pneumonitis is a major late complication in radiotherapy (RT) for lung cancer. Respiratory gating radiotherapy and deep inspiration breath hold are representative techniques to protect the normal lung by managing the movement of the tumor. However, these are highly patient-dependent techniques. Continuous positive airway pressure (CPAP) is used as an alternative, but it is unclear how much pressure will be effective. We aimed to determine the optimal pressure of CPAP for RT through changes in the dosimetric parameters and lung volume according to pressure. The air pressure was raised in five steps of 4, 7, 10, 14, and 17 cmH(2)O and a CT scan was performed at the baseline and at each pressure step, accompanied by contouring and RT planning. CPAP linearly increased lung volume and decreased the dosimetric parameter in the pressure range 7 to 13 cmH(2)O (p < 0.01). Above 13 cmH(2)O, V5 of the heart also showed a significant decrease (p < 0.01). We aimed to determine the optimal pressure of continuous positive airway pressure (CPAP) for radiotherapy (RT) through changes in the dosimetric parameters and lung volume according to pressure. Patients with locally advanced lung cancer, who underwent CPAP during computed tomography (CT) simulation, were included. The air pressure was raised in five steps of 4, 7, 10, 14, and 17 cmH(2)O and a CT scan was performed at the baseline and at each pressure step, accompanied by contouring and RT planning. Paired t- and Wilcoxon signed rank tests were used to compare the volumetric and dosimetric parameters according to pressure and interpressure. A total of 29 patients were selected, and 158 CT datasets were obtained. The lung volume increased significantly at all pressures (p < 0.01). The Dmean of the lung decreased significantly from 7 cmH(2)O (p < 0.01), the V5, V10, V15, and V20 of the lung decreased significantly from 7 cmH(2)O with increasing pressure, and the Dmean and V5 of the heart decreased significantly from 14 cmH(2)O with increasing pressure. The V50 showed no significant differences at any pressure. We recommend the use of at least 7 cmH(2)O with 14 cmH(2)O as the optimal pressure to achieve the effect of heart preservation. | Park, Jaehyeon; Yea, Ji Woon; Oh, Se An; Park, Jongmoo; Park, Jae Won; Lee, Jeong Eun | Yeungnam Univ, Dept Radiat Oncol, Med Ctr, Daegu 42415, South Korea; Yeungnam Univ, Dept Radiat Oncol, Coll Med, Daegu 42415, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiat Oncol, Daegu 41944, South Korea | ; Park, Ji Won/JCD-9105-2023; Park, Jun/H-7127-2019 | 57208665003; 55305655400; 55305602300; 56180048900; 57225161977; 57206732333 | kapicap@naver.com;jelee@knu.ac.kr; | CANCERS | CANCERS | 2072-6694 | 14 | 17 | SCIE | ONCOLOGY | 2022 | 5.2 | 29.7 | 0.38 | 2025-06-25 | 3 | 4 | radiotherapy; lung cancer; motion management; continuously positive airway pressure | INSPIRATION BREATH-HOLD; RADIATION PNEUMONITIS; RESPIRATORY MANEUVERS; CARDIAC VOLUME; IMPACT; MANAGEMENT; REDUCTION; THERAPY; MOTION; TUMORS | continuously positive airway pressure; lung cancer; motion management; radiotherapy | adult; advanced cancer; aged; Article; clinical article; clinical effectiveness; computer assisted tomography; continuous positive airway pressure; dosimetry; female; human; intensity modulated radiation therapy; lung cancer; lung volume; male; pressure measurement; simulation | English | 2022 | 2022-09 | 10.3390/cancers14174308 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Encoder-Weighted W-Net for Unsupervised Segmentation of Cervix Region in Colposcopy Images | Simple Summary The cervix region segmentation significantly affects the accuracy of diagnosis when analyzing colposcopy. Detecting the cervix region requires manual, intensive, and time-consuming labor from a trained gynecologist. In this paper, we propose a deep learning-based automatic cervix region segmentation method that enables the extraction of the region of interest from colposcopy images in an unsupervised manner. The segmentation performance with a Dice coefficient improved from 0.612 to 0.710 by applying the proposed loss function and encoder-weighted learning scheme and showed the best performance among all the compared methods. The automatically detected cervix region can improve the performance of image-based interpretation and diagnosis by suggesting where the clinicians should focus during colposcopy analysis. Cervical cancer can be prevented and treated better if it is diagnosed early. Colposcopy, a way of clinically looking at the cervix region, is an efficient method for cervical cancer screening and its early detection. The cervix region segmentation significantly affects the performance of computer-aided diagnostics using a colposcopy, particularly cervical intraepithelial neoplasia (CIN) classification. However, there are few studies of cervix segmentation in colposcopy, and no studies of fully unsupervised cervix region detection without image pre- and post-processing. In this study, we propose a deep learning-based unsupervised method to identify cervix regions without pre- and post-processing. A new loss function and a novel scheduling scheme for the baseline W-Net are proposed for fully unsupervised cervix region segmentation in colposcopy. The experimental results showed that the proposed method achieved the best performance in the cervix segmentation with a Dice coefficient of 0.71 with less computational cost. The proposed method produced cervix segmentation masks with more reduction in outliers and can be applied before CIN detection or other diagnoses to improve diagnostic performance. Our results demonstrate that the proposed method not only assists medical specialists in diagnosis in practical situations but also shows the potential of an unsupervised segmentation approach in colposcopy. | Park, Jinhee; Yang, Hyunmo; Roh, Hyun-Jin; Jung, Woonggyu; Jang, Gil-Jin | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Neopons, Daegu 41404, South Korea; Ulsan Natl Inst Sci & Technol, Dept Biomed Engn, Ulsan 44919, South Korea; Univ Ulsan, Coll Med, Ulsan Univ Hosp, Dept Obstet & Gynaecol, Ulsan 44033, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea | 57697146900; 57215700143; 36197365400; 58291338100; 7102646102 | pjhdrm@knu.ac.kr;hmyang@unist.ac.kr;0729345@uuh.ulsan.kr;wgjung@unist.ac.kr;gjang@ee.knu.ac.kr; | CANCERS | CANCERS | 2072-6694 | 14 | 14 | SCIE | ONCOLOGY | 2022 | 5.2 | 29.7 | 1.13 | 2025-06-25 | 9 | 12 | unsupervised learning; unsupervised segmentation; colposcopy; cervical cancer screening; W-Net | cervical cancer screening; colposcopy; unsupervised learning; unsupervised segmentation; W-Net | ablation therapy; Article; atrophy; colposcopy; convolutional neural network; deep learning; encoder weighted W net; feature extraction; human; image analysis; image segmentation; loss of function mutation; qualitative analysis; quantitative analysis; scanning laser ophthalmoscopy; training; uterine cervix; uterine cervix carcinoma in situ | English | 2022 | 2022-07 | 10.3390/cancers14143400 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Evaluation on Flexibility of Phenomenological Hardening Law for Automotive Sheet Metals | Constitutive modeling of sheet metals involves building a system of equations governing the material behavior under multi-axial stress states. In general, these equations require a hardening law that describes the stress-strain relationship. This study provides a thorough examination of the existing phenomenological hardening laws in the literature. Based on their ordinary differential equations, special efforts were made to discuss the degree of flexibility of these hardening laws. Four new phenomenological hardening laws were proposed during the discussions to capture the stress-strain relationship of automotive sheet metals, such as aluminum alloy and steel sheets. Then, applications of 18 hardening laws for fitting the uniaxial tensile stress-strain data of 12 automotive sheet metals were thoroughly compared. The comparisons reveal that the proposed hardening laws capture well the experimental stress strain data of all examined materials. Compared to several combined hardening laws, the proposed functions have comparable flexibility but require fewer parameters. | Quoc Tuan Pham; Kim, Young-Suk | Ton Duc Thang Univ, Inst Computat Sci, Div Computat Math & Engn, Ho Chi Minh City 756000, Vietnam; Ton Duc Thang Univ, Fac Civil Engn, Ho Chi Minh City 756000, Vietnam; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea | Kim, Sang-Hoon/AAA-2248-2020; Pham, Tuan/AAH-8010-2019 | 57191753992; 36065820800 | phamquoctuan@tdtu.edu.vn;caekim@knu.ac.kr; | METALS | METALS-BASEL | 2075-4701 | 12 | 4 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2022 | 2.9 | 29.7 | 0.42 | 2025-06-25 | 5 | 5 | automotive sheet metal; hardening law; aluminum alloys; steels; ordinary differential equation | HIGH-STRENGTH STEEL; OF-THE-ART; DUCTILE FRACTURE; BEHAVIOR; IDENTIFICATION; WORK; DEFORMATION; PREDICTION; CURVE; SIMULATION | aluminum alloys; automotive sheet metal; hardening law; ordinary differential equation; steels | English | 2022 | 2022-04 | 10.3390/met12040578 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Experimental verification of semimetallic band structure in PtSe2 via thermoelectric power measurements | This study presents an investigation of the band structure in a semimetallic two-dimensional (2D) PtSe2 nanosheet based on thermoelectric transport phenomena. Mechanically exfoliated PtSe2 nanosheets, including naturally doped nonneutral samples, were studied. The gatetuned electrical conductivity and thermoelectric power were measured by varying the temperature. Based on the combined effects of gatetuning and shifting of zero-gate energy level, the semimetallic band structure of 2D PtSe2 was confirmed in the band over a wide energy range. Furthermore, the temperature dependence of transport properties was investigated to determine the band structure and intrinsic properties. Published under an exclusive license by AIP Publishing. | Kim, Jeongmin; Youn, Seonhye; Bang, Joonho; Moon, Hongjae; Jang, Woosun; Roh, Jong Wook; Kim, Dong Hwan; Chang, Joonyeon; Lee, Wooyoung | DGIST, Div Nanotechnol, 333 Techno Jungang Daero, Daegu 42988, South Korea; Yonsei Univ, Dept Mat Sci & Engn, 50 Yonsei Ro, Seoul 03722, South Korea; Sungkyunkwan Univ, Dept Energy Sci, Suwon 16419, South Korea; Yonsei Univ, Ctr Artificial Synesthesia Mat Discovery, Seoul 03722, South Korea; Kyungpook Natl Univ, Sch Nano Mat Engn, Gyeongsangbuk Do 37224, South Korea; Korea Inst Sci & Technol, Nat Prod Inst, Seoul 02792, South Korea; Korea Inst Sci & Technol, Postsilicon Semicond Inst, Ctr Spintron, Seoul 02792, South Korea | Bang, Joonho/AFZ-9712-2022; Jang, Woosun/K-7112-2019 | 57203325094; 57218557480; 56168055600; 57193670680; 36930463300; 25638796100; 57195540717; 57203369778; 55498383000 | wooyoung@yonsei.ac.kr; | APPLIED PHYSICS LETTERS | APPL PHYS LETT | 0003-6951 | 1077-3118 | 120 | 4 | SCIE | PHYSICS, APPLIED | 2022 | 4 | 29.7 | 0.49 | 2025-06-25 | 3 | 4 | FIGURE; RISE | Platinum compounds; Selenium compounds; Structural properties; Temperature distribution; Transport properties; Electrical conductivity; Experimental verification; Gate tuning; Metallic bands; Metallics; Non-neutral; Thermoelectric power measurement; Thermoelectric transport; Transport phenomenon; Two-dimensional; Band structure | English | 2022 | 2022-01-24 | 10.1063/5.0076972 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Correction | Experimental verification of semimetallic band structure in PtSe2 via thermoelectric power measurements (vol 120, 043103 2022) | Kim, Jeongmin; Youn, Seonhye; Bang, Joonho; Moon, Hongjae; Jang, Woosun; Roh, Jong Wook; Kim, Dong Hwan; Chang, Joonyeon; Lee, Wooyoung | DGIST, Div Nanotechnol, 333 Techno Jungang Daero, Daegu 42988, South Korea; Yonsei Univ, Dept Mat Sci & Engn, 50 Yonsei Ro,Seodaemoon Gu, Seoul 03722, South Korea; Sungkyunkwan Univ, Dept Energy Sci, Suwon 16419, South Korea; Yonsei Univ, Ctr Artificial Synesthesia Mat Discovery, Seoul 03722, South Korea; Kyungpook Natl Univ, Sch Nano Mat Engn, Daegu 37224, Gyeongsangbug, South Korea; Korea Inst Sci & Technol, Nat Prod Inst, Seoul 02792, South Korea; Korea Inst Sci & Technol, Postsilicon Semicondtuctor Inst, Ctr Spintron, Seoul 02792, South Korea | Bang, Joonho/AFZ-9712-2022; Jang, Woosun/K-7112-2019 | 57203325094; 57218557480; 56168055600; 57193670680; 36930463300; 25638796100; 57195540717; 57203369778; 55498383000 | wooyoung@yonsei.ac.kr; | APPLIED PHYSICS LETTERS | APPL PHYS LETT | 0003-6951 | 1077-3118 | 120 | 20 | SCIE | PHYSICS, APPLIED | 2022 | 4 | 29.7 | 0 | 2025-06-25 | 1 | 0 | English | 2022 | 2022-05-16 | 10.1063/5.0097303 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Fabrication and Characterization of the Broccoli-like Structured CuO Thin Films Synthesized by a Facile Hydrothermal Method and Its Photoelectrochemical Water Splitting Application | CuO thin films with broccoli-like structure were prepared using a facile hydrothermal method to construct photocathodes for water-splitting application. The morphological, structural, and optical properties of thin films were characterized and measured using several techniques, including X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), photoluminescence (PL), and ultraviolet-visible spectroscopy (UV-Vis). The thickness, structure, and morphology of CuO thin films can be controlled by varying the precursor concentration (C-p) and reaction temperature (T-r), which are also discussed. Moreover, the electrical properties of CuO thin films were also measured in the three-electrode system. The photocurrent density of photocathodes, when synthesized by a 0.5 M solution at 150 degrees C for 12 h, was 0.5 mA/cm(2) at -0.6 V vs. Ag/AgCl, which is 1.8 times higher than that of photocathodes synthesized in a 0.1 M solution at 100 degrees C with the same reaction time. In addition, increasing the reaction temperature and precursor concentration aided in the enhancement of the IPCE and APCE values, which peaked at a wavelength range of 330-400 nm. | Nguyen Hoang Lam; Nguyen Tam Nguyen Truong; Chau Thi Thanh Thuy; Tamboli, Mohaseen S.; Tamboli, Asiya M.; Jung, Jinjoo; Ahn, Kwang-soon; Kim, Chang-Duk; Jung, Jae Hak | Yeungnam Univ, Sch Chem Engn, 280 Daehak Ro, Gyongsan 38541, South Korea; Korea Inst Energy Technol KENTECH, 200 Hyeokshin Ro, Naju 58330, South Korea; Kyungpook Natl Univ, Dept Phys, Daegu 702701, South Korea | ; Lam, Nguyen/KRO-9111-2024 | 58313026700; 25958384000; 57188972485; 6506784566; 57223215588; 55750032400; 7202870619; 57200982445; 13308234300 | nhlam@tvu.edu.vn;tamnguyentn@ynu.ac.kr;chauthuy041091@gmail.com;tamboli.mohseen@gmail.com;asiyashaikh2020@gmail.com;jjjung@knu.ac.kr;kstheory@ynu.ac.kr;duks@knu.ac.kr;jhjung@ynu.ac.kr; | METALS | METALS-BASEL | 2075-4701 | 12 | 3 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2022 | 2.9 | 29.7 | 0.75 | 2025-06-25 | 8 | 9 | CuO thin film; hydrothermal method; morphology; photocurrent density; water splitting | HYDROGEN EVOLUTION; OPTICAL-PROPERTIES; OXIDE; PHOTOCATHODES; PHOTOANODE; THICKNESS; LAYERS; CU2O | CuO thin film; Hydrothermal method; Morphology; Photocurrent density; Water splitting | English | 2022 | 2022-03 | 10.3390/met12030484 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Finite Element Analysis on Welding-Induced Distortion of Automotive Rear Chassis Component | Welding-induced distortion is a major concern for the industrial joining practice. The welding-induced distortion at the weldment between the coupled torsion beam axle (CTBA) of the automotive rear chassis parts and trailing arm connected to the wheel hub axle module seriously affects the tow angle, camber angle, and caster of the wheel axle. In this paper, the welding process between CTBA and trailing arm was numerically analyzed via SYSWELD (i.e., a finite element analysis code), using the material properties predicted via J-MatPro SW, material properties software, considering the thermo-mechanical-metallurgical properties of materials. From the numerical study for the weldment of CTBA and trailing arm, we predicted the welding and thermal distortions, temperature variation, microstructure, and residual stress at the concerned area. As a result, the temperature of the welded area was predicted between 102 degrees C and 840 degrees C at the end of weldment and converged to room temperature after 1000 s. The maximum portion of the martensite structure at the welded area was expected to be 55%. The expected distortions of the trailing arm after the weldment were 0.52 mm, -1.47 mm, and 0.44 mm in the x, y, and z-directions, respectively. Finally, the limitations of this research and recommendations are presented. | Kim, Jin-Jae; Bae, Moonki; Hong, Myoung-Pyo; Kim, Young-Suk | Kyungpook Natl Univ, Grad Sch, Daegu 41566, South Korea; Hyundai Motor Grp, R&D Div, Metall Mat Res Lab, Seoul 18280, South Korea; Korea Inst Ind Technol, Smart Mfg Technol R&D Grp, Daegu 711883, South Korea; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea | ; Kim, Sang-Hoon/AAA-2248-2020 | 57209555877; 57072755200; 57192270657; 36065820800 | jinjaekim@knu.ac.kr;BMK@hyundai.com;mp77@kitech.re.kr;caekim@knu.ac.kr; | METALS | METALS-BASEL | 2075-4701 | 12 | 2 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2022 | 2.9 | 29.7 | 0.42 | 2025-06-25 | 4 | 5 | chassis component; coupled torsion beam axle; finite element method; welding distortion; SYSWELD | RESIDUAL-STRESS; DEFORMATION; PREDICTION | Chassis component; Coupled torsion beam axle; Finite element method; SYSWELD; Welding distortion | English | 2022 | 2022-02 | 10.3390/met12020287 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Impact Toughness of Spring Steel after Bainite and Martensite Transformation | It has been reported that a multiphase microstructure with bainite, martensite, and retained austenite obtained by austempering, or quenching and tempering of spring steel containing Si, Mn, and Cr exhibits high strength and ductility. However, little research has been conducted on the bainite formation and impact fracture behavior of next-generation spring steel from the perspective of engineering and industrial applications. The microstructural transformation characteristics of bainite and martensite related to the heat treatment cycle on the maker side were quantitatively analyzed using electron backscatter diffraction (EBSD) and scanning electron microscopy (SEM) analyses. Moreover, the effects and mechanical properties of bainite and martensite formation in response to changes in lath length and width were studied and analyzed. That is, to obtain the mechanical properties of spring steel with the highest quality, tensile and impact specimens, whose microstructure and notch shape change according to the heat-treatment cycle, were prepared and studied. | Suh, Min-Soo; Nahm, Seung-Hoon; Suh, Chang-Min; Park, No-Keun | Korea Inst Energy Res, Daejeon 34129, South Korea; Korea Res Inst Stand & Sci, Daejeon 34113, South Korea; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Yeungnam Univ, Sch Mat Sci & Engn, Gyongsan 38541, South Korea | ; Park, Nokeun/A-8366-2013; PARk, Nokeun/A-8366-2013 | mssuh@kier.re.kr;shnahm@kriss.re.kr;cnasuh@knu.ac.kr;park@yu.ac.kr; | METALS | METALS-BASEL | 2075-4701 | 12 | 2 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2022 | 2.9 | 29.7 | 7 | spring steel; electron backscatter diffraction; bainite; martensite; austempering; lath; impact test | VARIANT SELECTION; FATIGUE BEHAVIOR; TEMPERATURE; HYDROGEN; CRACKING; SI | English | 2022 | 2022-02 | 10.3390/met12020304 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | MBP-11901 Inhibits Tumor Growth of Hepatocellular Carcinoma through Multitargeted Inhibition of Receptor Tyrosine Kinases | Simple Summary Although various treatments such as surgery and chemotherapy exist for advanced or unresectable HCC, most patients suffer from intractable diseases, having a poor prognosis. While immunotherapy using immune checkpoint inhibitors was recently proposed for HCC, only a small percentage of patients respond. Thus, there remains an unmet need for the development of therapeutic agents for the treatment of liver cancer. Here, we presented multi-RTKi MBP-11901, an innovative targeted anticancer agent for HCC, suggesting it as a new therapeutic strategy for the treatment of liver cancer. Hepatocellular carcinomas (HCCs) are aggressive tumors with a poor prognosis. Approved first-line treatments include sorafenib, lenvatinib, and a combination of atezolizumab and bevacizumab; however, they do not cure HCC. We investigated MBP-11901 as a drug candidate for HCC. Cell proliferation and cytotoxicity were evaluated using normal and cancer human liver cell lines, while Western blotting and flow cytometry evaluated apoptosis. The anticancer effect of MBP-11901 was verified in vitro through migration, invasion, colony formation, and JC-1 MMP assays. In mouse models, the tumor volume, tumor weight, and bodyweight were measured, and cancer cell proliferation and apoptosis were analyzed. The toxicity of MBP-11901 was investigated through GOT/GPT and histological analyses in the liver and kidney. The signaling mechanism of MBP-11901 was investigated through kinase assays, phosphorylation analysis, and in silico docking simulations. Results. MBP-11901 was effective against various human HCC cell lines, leading to the disappearance of most tumors when administered orally in animal models. This effect was dose-dependent, with no differences in efficacy according to administration intervals. MBP-11901 induced anticancer effects by targeting the signaling mechanisms of FLT3, VEGFR2, c-KIT, and PDGFR beta. MBP-11901 is suggested as a novel therapeutic agent for the treatment of advanced or unresectable liver cancer. | Park, Hyun Jin; Choi, Garam; Ha, Seongmin; Kim, Yesl; Choi, Min-Jin; Kim, Minsup; Islam, Md Kamrul; Chang, Yongmin; Kwon, Tae-Jun; Kim, Dongkyu; Jang, Eunbee; Kim, Tae Hwan; Chang, Sha Joung; Kim, Yeoun-Hee | Etnova Therapeut Corp, R&D Ctr, 124 Sagimakgol Ro, Seongnam Si 13207, South Korea; Kyungpook Natl Univ, Inst Biomed Engn Res, 680 Gukchaebosang Ro, Daegu 680, South Korea; InCerebro Drug Discovery Inst, Seoul 01811, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Preclin Res Ctr, 80 Cheombok Ro, Daegu 41061, South Korea; Daegu Catholic Univ, Coll Pharm, 13-13 Hayang Ro, Gyongsan 38430, South Korea | Islam, Md Kamrul/AAE-3221-2021; Islam, Md. Kamrul/AAE-3221-2021; Kim, Dong/AEG-4375-2022; Park, Hyun-Jin/HPE-8152-2023 | 57203526784; 56013903700; 57239556900; 57575471700; 57575891200; 56122945800; 57193930944; 7501840633; 35798369900; 57779034700; 57576108400; 57200570001; 57576322400; 57576538700 | phj0808@etnova.co.kr;garam1458@etnova.co.kr;996574@naver.com;yesl_kim@etnova.co.kr;zzz9924@etnova.co.kr;minsupkim.bio@gmail.com;mkislam2008@yahoo.com;ychang@knu.ac.kr;tjkwon@kmedihub.re.kr;dgkim728@kmedihub.re.kr;wkddmsql96@naver.com;thkim@cu.ac.kr;sjchang3136@etnova.co.kr;yhkim@etnova.co.kr; | CANCERS | CANCERS | 2072-6694 | 14 | 8 | SCIE | ONCOLOGY | 2022 | 5.2 | 29.7 | 0.38 | 2025-06-25 | 3 | 4 | hepatocellular carcinoma; targeted therapy; tyrosine kinase inhibitor; anticancer agent; complete response | anticancer agent; complete response; hepatocellular carcinoma; targeted therapy; tyrosine kinase inhibitor | alanine aminotransferase; antineoplastic agent; aspartate aminotransferase; CD135 antigen; fibroblast growth factor receptor 1; fibroblast growth factor receptor 2; mammalian target of rapamycin; MAP4K2 protein; mbp 11901; mitogen activated protein kinase 1; mitogen activated protein kinase 3; mitogen activated protein kinase kinase 1; mitogen activated protein kinase kinase 2; mitogen activated protein kinase kinase 5; platelet derived growth factor beta receptor; protein tyrosine kinase; sorafenib; stem cell factor; unclassified drug; vasculotropin receptor 2; alanine aminotransferase blood level; animal cell; animal experiment; animal model; animal tissue; antineoplastic activity; Article; aspartate aminotransferase blood level; binding affinity; body weight; cancer inhibition; cell counting kit 8 assay; cell growth assay; cell invasion; cell migration; cell proliferation; cell proliferation assay; colony formation; colony formation assay; cytotoxicity; cytotoxicity assay; dose response; drug cytotoxicity; flow cytometry; histology; human; human cell; human tissue; immunofluorescence assay; immunohistochemistry; in vitro study; in vivo study; liver cell carcinoma; male; mitochondrial membrane potential; molecular docking; mouse; mouse model; nonhuman; protein phosphorylation; transwell assay; tumor volume; tumor weight; tumor xenograft; Western blotting | English | 2022 | 2022-04 | 10.3390/cancers14081994 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Optimal delipidation solvent to secure extracellular matrix from human perirenal adipose tissue | The objective of this study was to select the optimal delipidation solvent for preparation of human perirenal adipose tissue-derived extracellular matrix (ECM). Human perirenal adipose tissue can be obtained in large amounts during surgery, and it can be an alternative source of human ECM. Delipidation is an essential procedure for the ECM preparation, because lipid strongly inhibits regeneration of target tissue. Isopropanol has been widely used as a delipidation solvent for adipose tissue. However, because adipose tissue is mostly composed of nonpolar lipid, a nonpolar solvent might be more effective for delipidation. We evaluated the delipidation efficiency of acetone, chloroform, methanol, ether, ethanol, isopropanol, water, chloroform/methanol, ethanol/heptane, ether/methanol, hexane/ethanol, and butanol/methanol solvents for ECM extraction from human perirenal adipose tissue. Among them, acetone-treated adipose tissue showed the greatest delipidation efficiency (93.05%), significantly lower residual DNA content, and the greatest residual collagen concentration (42.49 +/- 0.05 mu g/g). In addition, acetone-treated tissue also had well-preserved ultrastructure with high porosity and significantly low in vitro cytotoxicity. These results suggested that acetone may be an optimal delipidation solvent for extraction of ECM from human perirenal adipose tissue. | Chun, So Young; Ha, Yun-Sok; Yoon, Bo Hyun; Lee, Eun Hye; Kim, Bo Mi; Gil, Haejung; Han, Man-Hoon; Kwon, Tae Gyun; Kim, Bum Soo; Lee, Jun Nyung | Kyungpook Natl Univ Hosp, BioMed Res Inst, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Urol, Daegu, South Korea; Kyungpook Natl Univ, Joint Inst Regenerat Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Pathol, 130 Dongdeok Ro, Daegu 41944, South Korea | Kim, Shin-Hyun/F-5504-2012; Lee, Yun-Soo/AAA-7364-2022 | 8688166900; 35487226400; 57218931150; 57189661699; 57218929773; 57221906264; 57194067936; 15073765400; 57202817150; 16301364600 | dock97@hanmail.net;ljnlover@gmail.com; | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | J BIOMED MATER RES A | 1549-3296 | 1552-4965 | 110 | 4 | SCIE | ENGINEERING, BIOMEDICAL;MATERIALS SCIENCE, BIOMATERIALS | 2022 | 4.9 | 29.7 | 0.23 | 2025-06-25 | 2 | 3 | adipose tissue; delipidation; extracellular matrix; perirenal; solvent | DENATURED COLLAGEN; FAT; DECELLULARIZATION; PURIFICATION; EXTRACTION; GRAFTS; VALVES | adipose tissue; delipidation; extracellular matrix; perirenal; solvent | Adipose Tissue; Extracellular Matrix; Humans; Solvents; Water; Chlorine compounds; Efficiency; Ethanol; Ethers; Organic solvents; Solvent extraction; Tissue; Tissue regeneration; 2 propanol; acetone; alcohol; chloroform; collagen; collagen type 1; ether; glycolipid; glycosaminoglycan; heptane; hexane; laminin; methanol; phospholipid; water; solvent; Adipose tissue; Alternative source; Delipidation; Extracellular matrices; Isopropanol; Large amounts; Lipid A; Non-polar; Perirenal; Target tissues; adipose tissue; Article; autolysis; cell proliferation; cell viability; controlled study; cytotoxicity; decellularized extracellular matrix; delipidation; DNA isolation; extracellular matrix; freeze drying; human; human cell; human tissue; immunohistochemistry; lipid analysis; Masson staining; MTT assay; perirenal fat; porosity; scanning electron microscopy; target tissue; tissue regeneration; ultrastructure; adipose tissue; chemistry; Acetone | English | 2022 | 2022-04 | 10.1002/jbm.a.37341 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Correction | Predicting survival in heart failure: a risk score based on machine-learning and change point algorithm (vol 110, pg 1321, 2021) | Kim, Wonse; Park, Jin Joo; Lee, Hae-Young; Kim, Kye Hun; Yoo, Byung-Su; Kang, Seok-Min; Baek, Sang Hong; Jeon, Eun-Seok; Kim, Jae-Joong; Cho, Myeong-Chan; Chae, Shung Chull; Oh, Byung-Hee; Kook, Woong; Choi, Dong-Ju | Seoul Natl Univ, Dept Math Sci, Gwanak Ro 1, Seoul, South Korea; Seoul Natl Univ, Div Cardiol, Dept Internal Med, Cardiovasc Ctr,Bundang Hosp, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Chonnam Natl Univ, Heart Res Ctr, Gwangju, South Korea; Yonsei Univ, Dept Internal Med, Wonju Coll Med, Wonju, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Catholic Univ Korea, Dept Internal Med, Seoul, South Korea; Sungkyunkwan Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Asan Med Ctr, Dept Internal Med, Seoul, South Korea; Chungbuk Natl Univ, Dept Internal Med, Coll Med, Cheongju, South Korea; Kyungpook Natl Univ, Dept Internal Med, Coll Med, Daegu, South Korea; Mediplex Sejong Hosp, Dept Internal Med, Incheon, South Korea; Seoul Natl Univ, Div Cardiol, Dept Internal Med, Cardiovasc Ctr,Bundang Hosp, Gumiro 166, Gyeonggi Do, Seongnam, South Korea; MetaEyes, 41 Yonsei Ro,5da Gil, Seoul, South Korea | Choi, Dong-Ju/J-5686-2012; Oh, Byung-Hee/G-9875-2011; Jeong, Gi/AAB-2830-2021 | 57202605224; 35799900000; 56151235500; 56150430800; 7102851884; 7405685375; 7201371594; 7004279641; 36065764100; 7401727518; 7101962036; 57216293873; 57204406090; 35274349200 | woongkook@snu.ac.kr;djchoi@snubh.org; | CLINICAL RESEARCH IN CARDIOLOGY | CLIN RES CARDIOL | 1861-0684 | 1861-0692 | 111 | 4 | SCIE | CARDIAC & CARDIOVASCULAR SYSTEMS | 2022 | 5 | 29.7 | 0 | 2025-06-25 | 0 | 0 | erratum | English | 2022 | 2022-04 | 10.1007/s00392-021-01947-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Reliability of Alkaline Phosphatase for Differentiating Flare Phenomenon from Disease Progression with Bone Scintigraphy | Simple Summary Bone scintigraphy is the most widely used radionuclide technique to investigate bone metastasis, primarily due to its reasonable time and cost factor. However, it is important to recognize that bone scintigraphy to assess treatment response sometimes shows a "flare phenomenon", which can be misinterpreted as disease progression. Distinction between flare phenomenon and disease progression could help in the decision to continue effective treatments in patients with flare phenomenon and to cease ineffective treatments and consider other salvage treatment plans in patients with disease progression. Despite many methods having been tried to answer this question, there was still no reliable way to differentiate between flare phenomenon and progression of bone metastases. Our results suggest that ALP is a useful serologic marker to differentiate flare phenomenon from disease progression on bone scintigraphy in breast or prostate cancer patients with bone metastasis. The flare phenomenon (FP) on bone scintigraphy after the initiation of systemic treatment seriously complicates evaluations of therapeutic response in patients with bone metastases. The aim of this study was to evaluate whether serum alkaline phosphatase (ALP) can differentiate FP from disease progression on bone scintigraphy in these patients. Breast or prostate cancer patients with bone metastases who newly underwent systemic therapy were reviewed. Pretreatment baseline and follow-up data, including age, pathologic factors, type of systemic therapy, radiologic and bone scintigraphy findings, and ALP levels, were obtained. Univariate and multivariate analyses of these factors were performed to predict FP. An increased extent and/or new lesions were found in 160 patients on follow-up bone scintigraphy after therapy. Among the 160 patients, 80 (50%) had an improvement on subsequent bone scintigraphy (BS), while subsequent scintigraphy also showed an increased uptake in 80 (50%, progression). Multiple regression analysis revealed that stable or decreased ALP was an independent predictor for FP (p < 0.0001). ALP was an independent predictor for FP on subgroup analysis for breast and prostate cancer (p = 0.001 and p = 0.0223, respectively). Results of the study suggest that ALP is a useful serologic marker to differentiate FP from disease progression on bone scintigraphy in patients with bone metastasis. Clinical interpretation for scintigraphic aggravation can be further improved by the ALP data and it may prevent fruitless changes of therapeutic modality by misdiagnosis of disease progression in cases of FP. | Jung, Ji-hoon; Hong, Chae-Moon; Jo, Il; Jeong, Shin-Young; Lee, Sang-Woo; Lee, Jaetae; Ahn, Byeong-Cheol | Hanyang Univ, Dept Radiol, Coll Med, Guri Hosp, Guri 11923, South Korea; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41944, South Korea | ; Lee, Sang-Jun/A-3892-2015; lee, sangwoo/KUD-1906-2024 | 57061328700; 37050876700; 57394389500; 36164032500; 57196249819; 7601451907; 7202791511 | hoon2510@nate.com;shahking@hanmail.net;eye12knowu@hanmail.net;syjeong@knu.ac.kr;swleenm@knu.ac.kr;jaetae@knu.ac.kr;abc2000@knu.ac.kr; | CANCERS | CANCERS | 2072-6694 | 14 | 1 | SCIE | ONCOLOGY | 2022 | 5.2 | 29.7 | 0.76 | 2025-06-25 | 7 | 8 | bone scintigraphy; flare phenomenon; alkaline phosphatase; bone metastasis; breast cancer; prostate cancer | RESISTANT PROSTATE-CANCER; METABOLIC MARKERS; BREAST-CANCER; SYSTEMIC THERAPY; PHASE-II; METASTASES; SCAN; CHEMOTHERAPY; DIAGNOSIS; WOMEN | Alkaline phosphatase; Bone metastasis; Bone scintigraphy; Breast cancer; Flare phenomenon; Prostate cancer | alkaline phosphatase; radioisotope; adult; aged; alkaline phosphatase blood level; Article; bone metastasis; bone scintiscanning; breast cancer; cancer patient; computer assisted tomography; contrast enhancement; controlled study; disease exacerbation; human; major clinical study; male; multiple regression; multivariate analysis; prostate cancer; reliability; salvage therapy; serology; systemic therapy; treatment response; univariate analysis; very elderly | English | 2022 | 2022-01 | 10.3390/cancers14010254 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Risk Assessment of Postoperative Pneumonia in Cancer Patients Using a Common Data Model | Simple Summary The incidence of postoperative pneumonia (POP) in patients with cancer is high owing to functional impairment of the immune system associated with cancer and additional lung damage caused by surgery. The incidence of POP following major cancer surgeries is unclear. Therefore, we investigated the incidence and risk factors of POP after cancer surgery in patients with the five most common cancers in Korea using a common data model (CDM). The CDM was a method to easily solve clinical questions using medical big data. The cumulative POP incidence in the five cancers using the CDM was approximately 3%. POP was most common in lung cancer (n = 91, 4.5%), followed by gastric (n = 133, 3.3%), colon (n = 19, 3.1%), liver (n = 14, 1.7%), and breast (n = 5, 0.5%) cancers. Older age, male sex, chronic pulmonary disease, mood disorder, and cerebrovascular disease were POP risk factors in patients with cancer. The incidence of postoperative pneumonia (POP) in patients with cancer is high, but its incidence following major cancer surgeries is unclear. Therefore, we investigated the incidence and risk factors of POP after surgery in patients with the five most common cancers in Korea using a common data model (CDM). Patients aged >19 years who underwent gastric, colon, liver, lung, or breast cancer surgery between January 2011 and December 2020 were included, excluding patients who underwent chemotherapy or radiotherapy. Pneumonia was defined as a pneumonia diagnosis code in patients hospitalized postoperatively. Gastric, colon, lung, breast, and liver cancers were noted in 4004 (47.4%), 622 (7.4%), 2022 (24%), 958 (11.3%), and 839 (9.9%) of 8445 patients, respectively. The cumulative POP incidence was 3.1% (n = 262), with the highest incidence in lung cancer (n = 91, 4.5%), followed by gastric (n = 133, 3.3%), colon (n = 19, 3.1%), liver (n = 14, 1.7%), and breast (n = 5, 0.5%) cancers. In multivariable analysis, older age, male sex, history of chronic pulmonary disease, mood disorder, and cerebrovascular disease were POP predictors. The cumulative POP incidence in the five cancers using the CDM was approximately 3%. Older age, male sex, chronic pulmonary disease, mood disorder, and cerebrovascular disease were POP risk factors in patients with cancer. | Lee, Yong Hoon; Kim, Do-Hoon; Kim, Jisun; Lee, Jaetae | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Med Big Data Res Ctr, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Med Informat, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41944, South Korea | Lee, Jaetae/ABF-3980-2020 | 57199022948; 55624468392; 58147425600; 7601451907 | jaetae@knu.ac.kr; | CANCERS | CANCERS | 2072-6694 | 14 | 23 | SCIE | ONCOLOGY | 2022 | 5.2 | 29.7 | 0.28 | 2025-06-25 | 4 | 3 | postoperative pneumonia; cancer; common data model | BACTERIAL-COLONIZATION; SURGERY; COMPLICATIONS; DISEASE | cancer; common data model; postoperative pneumonia | adult; age; aged; Article; breast cancer; cancer patient; cancer surgery; cerebrovascular disease; chronic lung disease; cohort analysis; colon cancer; common data model; controlled study; human; hypertension; immune system; incidence; Korea; liver cancer; lung cancer; major clinical study; middle aged; model; mood disorder; Parkinson disease; pneumonia; postoperative pneumonia; retrospective study; risk assessment; risk factor; sex; stomach cancer | English | 2022 | 2022-12 | 10.3390/cancers14235988 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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