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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
Article QRS complex characteristics and patient outcomes in out-of-hospital pulseless electrical activity cardiac arrest Background Pulseless electrical activity (PEA) is increasingly observed in out-of-hospital cardiac arrest (OHCA), but outcomes are still poor. We aimed to assess the relationship between QRS characteristics and outcomes of patients with OHCA with initial PEA (OHCA-P). Methods This prospective observational study included patients aged at least 18 years who developed OHCA-P between 1 January 2016 and 31 December 2018, and were enrolled in the Daegu Emergency Medical Services registry, South Korea. We performed multivariable logistic regression analyses to identify the associations between QRS characteristics and OHCA-P outcomes, in which QRS complexes were considered separately (model 1) and simultaneously (model 2). The primary outcome was survival to hospital discharge and the secondary outcome was a favourable neurological outcome. Results Of the 3659 patients with OHCA, 576 were enrolled (median age 73 years; 334 men). A higher QRS amplitude was associated with survival to hospital discharge and a favourable neurological outcome in model 1 (adjusted OR (aOR) 1.077 and 1.106, respectively; 95% CI 1.021 to 0.136 and 1.029 to 1.190, respectively) and model 2 (aOR 1.084 and 1.123, respectively; 95% CI 1.026 to 1.145 and 1.036 to 1.216, respectively). A QRS width of <120 ms was associated with survival to hospital discharge and a favourable neurological outcome in model 1 (aOR 3.371 and 4.634, respectively; 95% CI 1.633 to 6.960 and 1.562 to 13.144, respectively) and model 2 (aOR 3.213 and 5.103, respectively; 95% CI 1.568 to 6.584 and 1.682 to 15.482, respectively). Survival to hospital discharge and neurological outcome were not associated with QRS frequency. Conclusion OHCA-P outcomes were better when the initial QRS complex showed a higher amplitude or narrower width. Kim, Jung Ho; Ryoo, Hyun Wook; Kim, Jong-Yeon; Ahn, Jae Yun; Moon, Sungbae; Lee, Dong Eun; Mun, You Ho; Son, Jang Won Yeungnam Univ, Dept Emergency Med, Sch Med, Daegu, South Korea; Coll Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Emergency Med, Kyungpook Natl Univ Hosp, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Publ Hlth, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Chilgok Hosp, Sch Med, Dept Emergency Med, Daegu, South Korea; Yeungnam Univ, Div Cardiol, Internal Med, Sch Med, Daegu, South Korea ; Lee, Dong Eun/HTN-4501-2023; Ahn, Jae Yun/N-2652-2017; Kim, Jung Ho/LDE-9088-2024; Kim, Jungho/LDE-9088-2024 57205704177; 55350557500; 58382951500; 56937505400; 57191584601; 57202299238; 57210884077; 36646742500 ryoo@knu.ac.kr; EMERGENCY MEDICINE JOURNAL EMERG MED J 1472-0205 1472-0213 38 1 SCIE EMERGENCY MEDICINE 2021 3.814 29.7 0.6 2025-07-30 5 6 cardiac arrest; ECG; guidelines; prehospital care Aged; Aged, 80 and over; Cardiopulmonary Resuscitation; Electric Countershock; Electrocardiography; Emergency Medical Services; Female; Hospitalization; Humans; Male; Middle Aged; Out-of-Hospital Cardiac Arrest; Patient Discharge; Prospective Studies; Registries; Republic of Korea; Survival Rate; Time-to-Treatment; epinephrine; adult; advanced cardiac life support; aged; Article; basic life support; congestive cardiomyopathy; controlled study; coronary angiography; electric activity; emergency health service; emergency response time; extracorporeal oxygenation; female; heart arrhythmia; hospital discharge; human; logistic regression analysis; major clinical study; male; observational study; out of hospital cardiac arrest; practice guideline; priority journal; prospective study; pulseless electrical activity; QRS amplitude; QRS complex; QRS interval; resuscitation; return of spontaneous circulation; South Korea; treatment outcome; cardioversion; electrocardiography; hospitalization; middle aged; mortality; out of hospital cardiac arrest; pathophysiology; register; survival rate; time to treatment; very elderly English 2021 2021-01 10.1136/emermed-2020-209623 바로가기 바로가기 바로가기 바로가기
Article ASSESSMENT OF HYPERREFLECTIVE FOCI AFTER BEVACIZUMAB OR DEXAMETHASONE TREATMENT ACCORDING TO DURATION OF MACULAR EDEMA IN PATIENTS WITH BRANCH RETINAL VEIN OCCLUSION Purpose: To evaluate the association between hyperreflective foci (HRF) on spectral domain optical coherence tomography and therapeutic effect of intravitreal bevacizumab (IVB) or intravitreal dexamethasone implants (IVD) according to macular edema (ME) duration in branch retinal vein occlusion. Methods: Consecutive treatment-naive patients received IVB or IVD for at least 6 months. Each group was subdivided according to ME duration (= 3 months). Hyperreflective foci and best-corrected visual acuity were compared. Results: Of 139 eyes (139 patients), 69 received IVB and 70 received IVD. At baseline, eyes with ME >= 3 months had more outer and total retinal HRF than eyes with ME = 3 months group, IVD resulted in greater best-corrected visual acuity improvement than IVB (P = 0.017). Conclusion: Increased outer retinal HRF at baseline in eyes with ME >= 3 months together with a greater reduction in HRF at 6 months and better visual outcomes after IVD suggests that the inflammatory aspect of disease should be considered in the treatment of ME. Thus, IVD injection could be more appropriate for patients with a longer ME duration after branch retinal vein occlusion. Do, Jae Rock; Park, Su Jin; Shin, Jae Pil; Park, Dong Ho Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Ophthalmol, 130 Dongdeok Ro, Daegu 41944, South Korea; Sungkyunkwan Univ, Samsung Changwon Hosp, Sch Med, Dept Ophthalmol, Chang Won, South Korea 58600232100; 57194422330; 56517350400; 36676632900 DongHo_Park@knu.ac.kr; RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES RETINA-J RET VIT DIS 0275-004X 1539-2864 41 2 SCIE OPHTHALMOLOGY 2021 3.975 29.8 2.41 2025-07-30 15 17 bevacizumab; branch retinal vein occlusion; dexamethasone; hyperreflective foci; macular edema OPTICAL COHERENCE TOMOGRAPHY; INTRAVITREAL TRIAMCINOLONE; MICROGLIAL ACTIVATION; VISUAL OUTCOMES; DEGENERATION; ASSOCIATION; EXPRESSION; ACETONIDE bevacizumab; branch retinal vein occlusion; dexamethasone; hyperreflective foci; macular edema Aged; Angiogenesis Inhibitors; Bevacizumab; Dexamethasone; Female; Fluorescein Angiography; Follow-Up Studies; Glucocorticoids; Humans; Intravitreal Injections; Macular Edema; Male; Retinal Vein Occlusion; Retrospective Studies; Tomography, Optical Coherence; Vascular Endothelial Growth Factor A; Visual Acuity; angiogenesis inhibitor; bevacizumab; dexamethasone; glucocorticoid; vasculotropin A; aged; complication; female; fluorescence angiography; follow up; human; intravitreal drug administration; macular edema; male; optical coherence tomography; procedures; retina vein occlusion; retrospective study; visual acuity English 2021 2021-02 10.1097/iae.0000000000002826 바로가기 바로가기 바로가기 바로가기
Article Human-in-the-Loop Predictive Analytics Using Statistical Learning The human-in-the-loop cyber-physical system provides numerous solutions for the challenges faced by the doctors or medical practitioners. There is a linear trend of advancement and automation in the medical field for the early diagnosis of several diseases. One of the critical and challenging diseases in the medical field is coma. In the medical research field, currently, the prediction of these diseases is performed only using the data gathered from the devices only; however, the human's input is much essential to accurately understand their health condition to take appropriate decision on time. Therefore, we have proposed a healthcare framework involving the concept of artificial intelligence in the human-in- the-loop cyber-physical system. This model works via a response loop in which the human's intention is concluded by gathering biological signals and context data, and then, the decision is interpreted to a system action that is recognizable to the human in the physical environment, thereby completing the loop. In this paper, we have designed a model for early prognosis of coma using the electroencephalogram dataset. In the proposed approach, we have achieved the best results using a statistical learning algorithm called autoregressive integrated moving average in comparison to artificial neural networks and long short-term memory models. In order to measure the efficiency of our model, we have used the root mean squared error (RMSE), mean absolute error (MAE), and mean squared error (MSE) value to evaluate the linear models as it gives the difference between the measured value and true or correct value. We have achieved the least possible error value for our dataset. To conduct this experiment, we used the dataset available in the phsyionet opensource community. Ganesan, Anusha; Paul, Anand; Nagabushnam, Ganesan; Gul, Malik Junaid Jami Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu, South Korea Gul, Malik junaid jami/O-1392-2018; Paul, Anand/V-6724-2017; Ganesan, Anusha/ABA-2785-2021; Nagabushnam, Ganesan/ABA-2780-2021; Gul, Malik/O-1392-2018 57226711297; 56650522400; 57226713013; 57203752948 paul.editor@gmail.com; JOURNAL OF HEALTHCARE ENGINEERING J HEALTHC ENG 2040-2295 2040-2309 2021 SCIE HEALTH CARE SCIENCES & SERVICES 2021 3.822 29.8 0.65 2025-07-30 7 9 HEART-RATE-VARIABILITY; CYBER-PHYSICAL SYSTEM; SLEEP; DIAGNOSIS Artificial Intelligence; Coma; Humans; Neural Networks, Computer; Cyber Physical System; Diagnosis; Embedded systems; Errors; Mean square error; Neural networks; Predictive analytics; Auto-regressive integrated moving average; Biological signals; Mean absolute error; Mean squared error; Medical practitioner; Physical environments; Root mean squared errors; Statistical learning; Article; artificial intelligence; artificial neural network; coma; electroencephalogram; human; human in the loop cyber physical system; learning algorithm; long short term memory network; prognosis; statistical model; coma; Learning algorithms English 2021 2021-07-30 10.1155/2021/9955635 바로가기 바로가기 바로가기 바로가기
Article; Retracted Publication RETRACTED: Sports Training Health Analysis Algorithm Based on Heart Rhythm Feature Extraction and Convolutional Neural Network (Retracted Article) Intelligent sports equipment and software have emerged in the field of sports as a result of the advancement of information technology, allowing professional athletes to collect and visually display the movement and physical signs of the human body to aid in the planning of sports strategies. Intuitive data, on the other hand, cannot assist ordinary people who lack professional knowledge in exercising correctly. As a result, in the field of intelligent sports and health, effective use of collected exercise and physical sign data to analyze the user's personal physical condition and generate reasonable exercise suggestions has emerged as a research direction. In humans, the heart sound signal is a biological signal. It can help people detect and monitor heart health problems by analyzing the characteristics of heart sound signals. The goal of this paper is to use heart sound to identify and analyze athletes' training health. It provides a revolutionary health analysis algorithm based on heart rhythm feature extraction and convolutional neural networks, which is based on exercise training. It greatly improves the accuracy of the recognition and prediction of the athlete's training health status. Li, Jing; Lu, Yunhang; Xiao, Ziyi Xi An Jiao Tong Univ, Sports Ctr, Xian 710049, Shaanxi, Peoples R China; Kyungpook Natl Univ, Dept Phys Educ, Daegu 41566, South Korea; Yanching Inst Technol, Teaching & Res Off Coll Phys Educ, Langfang 065201, Peoples R China 57276351900; 57262012200; 57262012300 lijing.74@xjtu.edu.cn;luyunhang2021@163.com;xiaoziyiyanjing@163.com; JOURNAL OF HEALTHCARE ENGINEERING J HEALTHC ENG 2040-2295 2040-2309 2021 SCIE HEALTH CARE SCIENCES & SERVICES 2021 3.822 29.8 0.09 2025-07-30 1 1 PREDICTION Algorithms; Athletes; Heart Sounds; Humans; Neural Networks, Computer; Sports; Cardiology; Convolution; Convolutional neural networks; Extraction; Feature extraction; Sports; Analysis algorithms; Convolutional neural network; Features extraction; Heart sound signal; Human bodies; Ordinary people; Professional knowledge; Rhythm features; Sports equipment; Sports trainings; article; athlete; convolutional neural network; exercise; feature extraction; health status; heart rhythm; heart sound; human; prediction; algorithm; athlete; heart sound; sport; Heart English 2021 2021-08-31 10.1155/2021/2946044 바로가기 바로가기 바로가기 바로가기
Article Stabilizing Control of Complex Biological Networks Based on Attractor-Specific Network Reduction Global stabilization of complex biological networks means controlling the network to converge to a desired stable state, or an attractor, irrespective of initial states by perturbing a set of targeted nodes. Global stabilization is of paramount importance in systems biology since attractors represent key phenotypes of biological systems. Most of the previous attempts resort to either near-brute force or analytical searching with huge computational burden. In this article, we propose a novel control scheme that can achieve global stabilization of complex biological networks by alleviating such issues. For this purpose, a Boolean network model of complex biological networks is considered. We first reduce the Boolean network using a simple coordinate transformation with respect to the desired attractor without loss of the information on connectivity needed for global stabilization. We then identify control inputs by searching for a minimum node set whose perturbation makes the reduced Boolean network acyclic. The proposed control scheme is remarkable since our network reduction procedure needs no structural conditions, and global stabilization is guaranteed with modest computational complexity and scalability. To evaluate its applicability, the proposed control scheme is applied to random Boolean networks as well as to a regulation influence network describing the metastatic process of cells, and the results are analyzed in comparison with other approaches. Yang, Jung-Min; Lee, Chun-Kyung; Cho, Kwang-Hyun Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea; Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon 34141, South Korea Cho, Kwang-Hyun/C-1684-2011 57208450551; 57202995708; 35263583400 jmyang@ee.knu.ac.kr;chunkyung@kaist.ac.kr;ckh@kaist.ac.kr; IEEE TRANSACTIONS ON CONTROL OF NETWORK SYSTEMS IEEE T CONTROL NETW 2325-5870 2372-2533 8 2 SCIE AUTOMATION & CONTROL SYSTEMS;COMPUTER SCIENCE, INFORMATION SYSTEMS 2021 4.347 30.0 0.44 2025-07-30 9 9 Boolean networks (BNs); complex networks; network reduction; stabilizing control; systems biology DYNAMICS Boolean networks (BNs); complex networks; network reduction; stabilizing control; systems biology Complex networks; Process control; Stabilization; Biological networks; Biological system modeling; Boolean Networks; Global stabilization; Network reduction; Network-based; Regulation; Stabilizing control; Stable state; Systems biology; Biological systems English 2021 2021-06 10.1109/tcns.2020.3041423 바로가기 바로가기 바로가기 바로가기
Article Comparative Metabolite Profiling of Traditional and Commercial Vinegars in Korea Vinegar, composed of various organic acids, amino acids, and volatile compounds, has been newly recognized as a functional food with health benefits. Vinegar is produced through alcoholic fermentation of various raw materials followed by acetic acid fermentation, and detailed processes greatly vary between different vinegar products. This study performed metabolite profiling of various vinegar products using gas chromatography-mass spectrometry to identify metabolites that are specific to vinegar production processes. In particular, seven traditional vinegars that underwent spontaneous and slow alcoholic and acetic acid fermentations were compared to four commercial vinegars that were produced through fast acetic acid fermentation using distilled ethanol. A total of 102 volatile and 78 nonvolatile compounds were detected, and the principal component analysis of metabolites clearly distinguished between the traditional and commercial vinegars. Ten metabolites were identified as specific or significantly different compounds depending on vinegar production processes, most of which had originated from complex microbial metabolism during traditional vinegar fermentation. These process-specific compounds of vinegars may serve as potential biomarkers for fermentation process controls as well as authenticity and quality evaluation. Shin, Minhye; Kim, Jeong-Won; Gu, Bonbin; Kim, Sooah; Kim, Hojin; Kim, Won-Chan; Lee, Mee-Ryung; Kim, Soo-Rin Inha Univ, Dept Microbiol, Coll Med, Incheon 22212, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Jeonju Univ, Dept Environm Sci Biotechnol, Jeonju 55069, South Korea; Natl Agr Prod Qual Management Serv, Expt Res Inst, Gimcheon Si 39660, South Korea; Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea; Daegu Univ, Dept Food & Nutr, Gyongsan 38453, South Korea KIM, WON/AAJ-4506-2020; Kim, Soo Rin/X-2192-2019 57208401604; 57201153922; 57226499229; 36554561100; 56372903900; 55492085000; 55637250600; 36659584200 alsgp01@gmail.com;jungwon1103@naver.com;ant369369@naver.com;skim366@jj.ac.kr;rex7878@korea.kr;kwc@knu.ac.kr;mrlee@daegu.ac.kr;soorinkim@knu.ac.kr; METABOLITES METABOLITES 2218-1989 11 8 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY 2021 5.581 30.1 0.31 2025-07-30 4 4 GC/MS; metabolomics; vinegar; lactic acid; propanoic acid; erythritol; 2,3-butanediol VOLATILE COMPOUND PROFILES; ACETIC-ACID BACTERIA; BIOGENIC-AMINES; GAS-CHROMATOGRAPHY; ETHYL-ESTERS; FERMENTATION; IDENTIFICATION; SPECTROMETRY; YEASTS; WINES 2,3-butanediol; Erythritol; GC/MS; Lactic acid; Metabolomics; Propanoic acid; Vinegar English 2021 2021-08 10.3390/metabo11080478 바로가기 바로가기 바로가기 바로가기
Article Effect of Korean Red Ginseng on Plasma Ceramide Levels in Postmenopausal Women with Hypercholesterolemia: A Pilot Randomized Controlled Trial Cardiovascular disease (CVD) is a crucial cause of death in postmenopausal women. Plasma ceramide concentrations are correlated with the development of atherosclerosis and are significant predictors of CVD. Here, we conducted a 4-week, double-blinded, placebo-controlled clinical pilot study to investigate the effect of Korean red ginseng (KRG) on serum ceramide concentrations in 68 postmenopausal women with hypercholesterolemia. Patients were randomly assigned to two groups: the experimental group (n = 36) received KRG and the control (n = 32) group received placebo, 2 g each, once daily. Serum ceramides were measured using liquid chromatography-tandem mass spectrometry at baseline and study completion, with changes in serum ceramide levels as the primary end point. We detected significantly greater mean changes in C16 ceramide levels (d18:1/16:0: -6.4 +/- 6.3 pmol/mL vs. 14.6 +/- 6.8 pmol/mL, respectively, p = 0.040; d18:1/22:0: -20.8 +/- 24.4 pmol/mL vs. 71.1 +/- 26.2 pmol/mL, respectively, p = 0.020). Additionally, changes in the median C16 (d18:1/16:0) and C22 (d18:1/22:0) ceramide levels were significantly greater in KRG-group subjects with metabolic syndrome than those without. Therefore, we found that KRG decreases the serum levels of several ceramides in postmenopausal women with hypercholesterolemia, suggesting it may be beneficial for preventing CVD in these individuals. Kwon, Yu-Jin; Lee, Gyung-Min; Liu, Kwang-Hyeon; Jung, Dong-Hyuk Yonsei Univ, Yongin Severance Hosp, Dept Family Med, Coll Med, Yongin 16995, South Korea; Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, BK 21 FOUR Community Based Intelligent Novel Drug, Daegu 41566, South Korea Kwon, Yu-Jin/ACB-8082-2022 57188592099; 57217829865; 55768214700; 35738919100 digda3@yuhs.ac;lgm00179@naver.com;dstlkh@knu.ac.kr;balsan2@yuhs.ac; METABOLITES METABOLITES 2218-1989 11 7 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY 2021 5.581 30.1 0.31 2025-07-30 5 4 Korean red ginseng; ceramides; menopause; cardiovascular diseases; hypercholesterolemia CORONARY-ARTERY-DISEASE; CARDIOVASCULAR-DISEASE; LIPIDS; RISK; SPHINGOMYELIN; GINSENOSIDES; KINASE Cardiovascular diseases; Ceramides; Hypercholesterolemia; Korean red ginseng; Menopause acylcarnitine; cardiovascular agent; ceramide; diacylglycerol; ginseng extract; monoacylglycerol; phosphatidylethanolamine; placebo; plant extract; sphingomyelin; sphingomyelin phosphodiesterase; adult; alcohol consumption; Article; atherosclerosis; blood level; blood sampling; body mass; cardiovascular disease; cause of death; controlled study; correlational study; diabetes mellitus; diastolic blood pressure; double blind procedure; drug effect; female; ginseng; glucose blood level; high density lipoprotein cholesterol level; human; hypercholesterolemia; hypertension; leukocyte count; lipid blood level; liquid chromatography-mass spectrometry; major clinical study; metabolic syndrome X; middle aged; physical activity; pilot study; postmenopause; questionnaire; randomized controlled trial; smoking; systolic blood pressure; triacylglycerol blood level; waist circumference English 2021 2021-07 10.3390/metabo11070417 바로가기 바로가기 바로가기 바로가기
Article A compact photonic resonator absorption microscope for point of care digital resolution nucleic acid molecular diagnostics Rapid, sensitive, and selective detection of nucleic acid biomarkers for health diagnostic applications becomes feasible for point of care scenarios when the detection instrument is inexpensive, simple, and robust. Here, we report the design, implementation, and characterization of a point of care instrument for photonic resonator absorption microscopy (PRAM) that takes advantage of resonant optical coupling between plasmonic gold nanoparticle tags and a photonic crystal (PC) surface. Matching the PC resonant wavelength to the gold nanoparticle's surface plasmon wavelength generates localized and efficient quenching of the PC resonant reflection intensity, resulting in the ability to clearly detect and count individual gold nanoparticles when they are captured on the PC surface. Surface-captured nanoparticles are observed by illuminating the PC at normal incidence with polarized light from a low-intensity red LED, and recording of PC reflected intensity on an inexpensive CMOS image sensor. A contrast limited adaptive histogram equalization (CLAHE) image processing algorithm was applied to derive counts of captured nanoparticles. The instrument is utilized in the context of an activate capture + digital counting (AC + DC) assay for a specific miRNA sequence, using nucleic acid toehold probes applied to gold nano-urchin (AuNU) nanoparticles to achieve 160 aM detection limits in a 30 min. assay. (C) 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement Ghosh, Shreya; Li, Nantao; Xiong, Yanyu; Ju, Young-Gu; Rathslag, Michael P.; Onal, Ege G.; Falkiewicz, Erika; Kohli, Manish; Cunningham, Brian T. Univ Illinois, Holonyak Micro & Nanotechnol Lab, Urbana, IL 61801 USA; Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA; Kyungpook Natl Univ, Dept Phys Educ, 80 Daehak Ro, Daegu, South Korea; Univ Illinois, Dept Bioengn, Urbana, IL 61801 USA; Univ Illinois, Sch Integrat Biol, Urbana, IL 61801 USA; Univ Utah, Huntsman Canc Inst, Salt Lake City, UT 84112 USA; Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USA; Univ Illinois, Canc Ctr Illinois, Urbana, IL 61801 USA ; Xiong, Yanyu/AAB-7245-2021; Kohli, Manish/AAN-8862-2021 57161512400; 57188699534; 57218517526; 7202809560; 57219852419; 57225943483; 57225944485; 55681014400; 7202329774 bcunning@illinois.edu; BIOMEDICAL OPTICS EXPRESS BIOMED OPT EXPRESS 2156-7085 12 8 SCIE BIOCHEMICAL RESEARCH METHODS;OPTICS;RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING 2021 3.562 30.2 1.28 2025-07-30 18 20 INTERFEROMETRIC SCATTERING MICROSCOPY; BIOSENSOR; PLATFORM Biomolecules; Gold metallography; Image recording; Metal nanoparticles; Optical data processing; Plasmonic nanoparticles; Resonators; RNA; Surface plasmons; biological marker; gold nanoparticle; microRNA; nanoparticle; nucleic acid; Contrast Limited Adaptive Histogram Equalization (CLAHE); Detection instruments; Diagnostic applications; Image processing algorithm; Molecular diagnostics; Resonant reflection; Resonant wavelengths; Selective detection; Article; head and neck cancer; histogram; illumination; image processing; light scattering; limit of detection; lymphocyte; nonhuman; signal noise ratio; spectroscopy; tissue microarray; Gold nanoparticles English 2021 2021-08-01 10.1364/boe.427475 바로가기 바로가기 바로가기 바로가기
Correction A compact photonic resonator absorption microscope for point of care digital resolution nucleic acid molecular diagnostics (vol 12, pg 4637, 2021) Ghosh, Shreya; LI, Nantao; Xiong, Yanyu; Ju, Young-gu; Rathslag, Michael P.; Onal, Ege G.; Falkiewicz, Erika; Kohli, Manish; Cunningham, Brian T. Univ Illinois, Holonyak Micro & Nanotechnol Lab, Urbana, IL 61801 USA; Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA; Kyungpook Natl Univ, Dept Phys Educ, 80 Daehak Ro, Daegu, South Korea; Univ Illinois, Dept Bioengn, Urbana, IL 61801 USA; Univ Illinois, Sch Integrat Biol, Urbana, IL 61801 USA; Univ Utah, Huntsman Canc Inst, Salt Lake City, UT 84112 USA; Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USA; Univ Illinois, Canc Ctr Illinois, Urbana, IL 61809 USA Kohli, Manish/AAN-8862-2021; Xiong, Yanyu/AAB-7245-2021 57161512400; 57188699534; 57218517526; 7202809560; 57219852419; 57225943483; 57225944485; 55681014400; 7202329774 bcunning@illinois.edu; BIOMEDICAL OPTICS EXPRESS BIOMED OPT EXPRESS 2156-7085 12 8 SCIE BIOCHEMICAL RESEARCH METHODS;OPTICS;RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING 2021 3.562 30.2 0 2025-07-30 0 0 erratum English 2021 2021-08-01 10.1364/boe.438307 바로가기 바로가기 바로가기 바로가기
Article A novel apoptosis probe, cyclic ApoPep-1, for in vivo imaging with multimodal applications in chronic inflammatory arthritis Apoptosis plays an essential role in the pathophysiologic processes of rheumatoid arthritis. A molecular probe that allows spatiotemporal observation of apoptosis in vitro, in vivo, and ex vivo concomitantly would be useful to monitoring or predicting pathophysiologic stages. In this study we investigated whether cyclic apoptosis-targeting peptide-1 ((C)ApoPep-1) can be used as an apoptosis imaging probe in inflammatory arthritis. We tested the utility of (C)ApoPep-1 for detecting apoptotic immune cells in vitro and ex vivo using flow cytometry and immunofluorescence. The feasibility of visualizing and quantifying apoptosis using this probe was evaluated in a murine collagen-induced arthritis (CIA) model, especially after treatment. (C)ApoPep-1 peptide may successfully replace Annexin V for in vitro and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay for ex vivo in the measurement of apoptotic cells, thus function as a sensitive probe enough to be used clinically. In vivo imaging in CIA mice revealed that (C)ApoPep-1 had 42.9 times higher fluorescence intensity than Annexin V for apoptosis quantification. Furthermore, it may be used as an imaging probe for early detection of apoptotic response in situ after treatment. The (C)ApoPep-1 signal was mostly co-localized with the TUNEL signal (69.6% of TUNEL+ cells) in defined cell populations in joint tissues of CIA mice. These results demonstrate that (C)ApoPep-1 is sufficiently sensitive to be used as an apoptosis imaging probe for multipurpose applications which could detect the same target across in vitro, in vivo, to ex vivo in inflammatory arthritis. So, In-Seop; Kang, Jin Hee; Hong, Jung Wan; Sung, Shijin; Hasan, Al Faruque; Sa, Keum Hee; Han, Seung Woo; Kim, In San; Kang, Young Mo Kyungpook Natl Univ, Dept Internal Med Rheumatol, Sch Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu, South Korea; Kyungpook Natl Univ, Dept Biochem & Cell Biol, Sch Med, Daegu, South Korea; Korea Inst Sci & Technol, Biomed Res Inst, Ctr Theragnosis, Seoul, South Korea ; Al, Faruque/U-9865-2019; Li, Shaofu/O-2241-2019; Han, Seungwoo/R-5326-2019; kang, tae/K-2099-2015 7004320789; 55425883500; 57190075064; 55787126100; 57222194299; 7801506165; 55246807000; 34770432800; 26221798000 ymkang@knu.ac.kr; APOPTOSIS APOPTOSIS 1360-8185 1573-675X 26 3-4 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;CELL BIOLOGY 2021 5.561 30.5 0.09 2025-07-30 2 1 Cyclic ApoPep-1; Probe; Apoptosis imaging; Rheumatoid arthritis; Multipurpose applications Apoptosis imaging; Cyclic ApoPep-1; Multipurpose applications; Probe; Rheumatoid arthritis Animals; Apoptosis; Arthritis; Arthritis, Experimental; Arthritis, Rheumatoid; Diagnostic Imaging; Disease Models, Animal; Fluorescent Dyes; In Situ Nick-End Labeling; Mice; Oligopeptides; cyclic apoptosis targeting peptide 1; cyclopeptide; unclassified drug; cysteinyl-glutaminyl-arginyl-prolyl-prolyl-arginine; fluorescent dye; oligopeptide; animal cell; animal experiment; animal model; animal tissue; apoptosis; apoptotic cell percentage; Article; cell culture; cell isolation; collagen-induced arthritis; controlled study; ex vivo study; flow cytometry; fluorescence imaging; fluorescence intensity; human; human cell; immunocompetent cell; immunofluorescence; in vitro study; in vivo study; Jurkat cell line; male; molecular probe; mouse; multimodal imaging; nonhuman; peripheral blood mononuclear cell; priority journal; quantitative analysis; rheumatoid arthritis; synovial fluid; T lymphocyte; tissue section; treatment response; TUNEL assay; animal; apoptosis; arthritis; chemistry; diagnostic imaging; disease model; experimental arthritis; procedures; rheumatoid arthritis English 2021 2021-04 10.1007/s10495-021-01659-z 바로가기 바로가기 바로가기 바로가기
Article Interleukin-10 Attenuates Liver Fibrosis Exacerbated by Thermoneutrality Background: Crosstalk between brown adipose tissue (BAT) and the liver is receiving increasing attention. This study investigated the effect of BAT dysfunction by thermoneutral (TN) housing on liver fibrosis in mice and examined the effect of secreted factors from brown adipocytes on the activation of hepatic stellate cells (HSCs). Methods: The carbon tetrachloride (CCl4)-induced liver fibrosis mouse model was used to evaluate fibrotic changes in the livers of mice housed under standard and TN conditions. The effect of BAT on the activation of HSCs was examined using cultured cells treated with conditioned media from brown adipocytes. Results: Under TN conditions, mice with CCl4-induced liver fibrosis exhibited increased liver injury, collagen deposition, and alpha smooth muscle actin (alpha-SMA) expression in the liver compared with mice maintained at room temperature. The numbers of liver-infiltrating immune cells and T cells producing IL-17A and IFN-gamma were also significantly increased in the livers of mice housed under TN conditions. Treatment of HSCs with conditioned media from brown adipocytes markedly attenuated HSC activation, as shown by down-regulated alpha-SMA expression at day 4, day 7 and day 10 of culture. At thermoneutrality, with CCl4 administration, IL-10-deficient mice exhibited more severe liver fibrosis than wild-type mice. Interestingly, conditioned media from IL-10-deficient brown adipocytes could up-regulate the expression of alpha-SMA and induce HSCs activation. Conclusions: BAT inactivation by thermoneutrality contributes to the activation of pro-inflammatory and pro-fibrotic pathways in mice with CCl4-induced liver fibrosis. Normal brown adipocytes secreted factors that impair the activation of HSCs, while this protective effect was lost in IL-10-deficient brown adipocytes. Thus, the BAT-liver axis may serve as a potential therapeutic target for liver fibrosis, and IL-10 may be a key factor regulating the activation of HSCs by BAT. Ha Thi Nga; Moon, Ji Sun; Tian, Jingwen; Lee, Ho Yeop; Kim, Seok-Hwan; Lee, Young-Sun; Jeon, Jae-Han; Yi, Hyon-Seung Chungnam Natl Univ, Lab Endocrinol & Immune Syst, Sch Med, Daejeon, South Korea; Chungnam Natl Univ, Dept Med Sci, Sch Med, Daejeon, South Korea; Chungnam Natl Univ, Res Ctr Endocrine & Metab Dis, Sch Med, Daejeon, South Korea; Chungnam Natl Univ, Dept Surg, Sch Med, Daejeon, South Korea; Korea Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Dept Internal Med, Sch Med, Daegu, South Korea Yi, Hyon-Seung/ABA-2729-2022; Lee, Young-Sun/ABI-6420-2020; Kim, Seok-Hwan/G-9981-2015 57218201578; 57207780661; 57218201812; 57221714890; 55899471100; 13407433000; 36910340400; 55376878100 jmpbooks@cnu.ac.kr; FRONTIERS IN MEDICINE FRONT MED-LAUSANNE 2296-858X 8 SCIE MEDICINE, GENERAL & INTERNAL 2021 5.058 30.5 1.26 2025-07-30 16 17 liver fibrosis; hepatic stellate cells; thermoneutrality; brown adipose tissue; IL-10; conditioned media BROWN ADIPOSE-TISSUE; HEPATIC STELLATE CELLS; T-CELLS; ACTIVATION; EXPRESSION; RECEPTOR; DISEASE; OBESITY; STRESS; IMMUNE brown adipose tissue; conditioned media; hepatic stellate cells; IL-10; liver fibrosis; thermoneutrality alanine aminotransferase; alpha smooth muscle actin; aspartate aminotransferase; carbon tetrachloride; CD11b antigen; CD3 antigen; CD4 antigen; CD8 antigen; cholesterol; collagen; gamma interferon; Hermes antigen; interleukin 10; interleukin 17; interleukin 1beta; interleukin 6; L selectin; mitogen activated protein kinase 1; mitogen activated protein kinase 3; mitogen activated protein kinase p38; triacylglycerol; uncoupling protein 1; alanine aminotransferase blood level; animal experiment; animal model; animal tissue; Article; aspartate aminotransferase blood level; brown adipose tissue; carbon tetrachloride-induced liver cirrhosis; cell activation; cell infiltration; cell isolation; cholesterol blood level; controlled study; disease severity; down regulation; environmental temperature; enzyme linked immunosorbent assay; flow cytometry; hepatic stellate cell; histology; immunocompetent cell; immunohistochemistry; limit of quantitation; liver cell; liver tissue; male; mouse; mouse model; nonhuman; oxidative phosphorylation; pathogenesis; protein expression; real time polymerase chain reaction; T lymphocyte; temperature; thermoneutrality; triacylglycerol blood level; upregulation; Western blotting English 2021 2021-05-26 10.3389/fmed.2021.672658 바로가기 바로가기 바로가기 바로가기
Article Sulforaphane Alleviates Particulate Matter-Induced Oxidative Stress in Human Retinal Pigment Epithelial Cells Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly, and oxidative damage to retinal pigment epithelial (RPE) cells plays a major role in the pathogenesis of AMD. Exposure to high levels of atmospheric particulate matter (PM) with an aerodynamic diameter of <2.5 mu m (PM2.5) causes respiratory injury, primarily due to oxidative stress. Recently, a large community-based cohort study in the UK reported a positive correlation between PM2.5 exposure and AMD. Sulforaphane (SFN), a natural isothiocyanate found in cruciferous vegetables, has known antioxidant effects. However, the protective effects of SNF in the eye, especially in the context of AMD, have not been evaluated. In the present study, we evaluated the effect of SFN against PM2.5-induced toxicity in human RPE cells (ARPE-19) and elucidated the molecular mechanism of action. Exposure to PM2.5 decreased cell viability in ARPE-19 cells in a time- and dose-dependent manner, potentially due to elevated intracellular reactive oxygen species (ROS). SFN treatment increased ARPE-19 cell viability and decreased PM2.5-induced oxidative stress in a dose-dependent manner. PM2.5-induced downregulation of serum- and glucocorticoid-inducible kinase 1 (SGK1), a cell survival factor, was recovered by SFN. PM2.5 treatment decreased the enzymatic activities of the antioxidant enzymes including superoxide dismutase and catalase, which were restored by SFN treatment. Taken together, these findings suggest that SFN effectively alleviates PM2.5-induced oxidative damage in human ARPE-19 cells via its antioxidant effects, and that SFN can potentially be used as a therapeutic agent for AMD, particularly in cases related to PM2.5 exposure. Sim, Hyunchae; Lee, Wonhwa; Choo, Samyeol; Park, Eui Kyun; Baek, Moon-Chang; Lee, In-Kyu; Park, Dong Ho; Bae, Jong-Sup Kyungpook Natl Univ, Coll Pharm, Daegu, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Pathol & Regenerat Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Daegu, South Korea; Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Aging & Metab, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Ophthalmol, Sch Med, Daegu, South Korea Bae, Jong-Sup/AAU-9724-2020; Lee, In-Kyu/AAR-6374-2021; Lee, Wonhwa/GLQ-6506-2022 57219098739; 50161632800; 57219092520; 37071072400; 7006013097; 36071537600; 36676632900; 16021543200 DongHo_Park@knu.ac.kr;baejs@knu.ac.kr; FRONTIERS IN MEDICINE FRONT MED-LAUSANNE 2296-858X 8 SCIE MEDICINE, GENERAL & INTERNAL 2021 5.058 30.5 1.38 2025-07-30 12 13 age-related macular degeneration; retinal pigment epithelium; oxidative stress; retina; choroid IN-VITRO; MACULAR DEGENERATION; LUNG; INFLAMMATION; MECHANISMS; APOPTOSIS; DAMAGE; RESPONSES; PHASE; MODEL age-related macular degeneration; choroid; oxidative stress; retina; retinal pigment epithelium catalase; dexamethasone; reactive oxygen metabolite; serum and glucocorticoid regulated kinase 1; sulforaphane; superoxide dismutase; age related macular degeneration; apoptosis; Article; cell viability; cells; cohort analysis; cytotoxicity; down regulation; enzyme activity; human; human cell; oxidative stress; particulate matter 2.5; PM2.5 exposure; retina pigment cell; United Kingdom English 2021 2021-06-17 10.3389/fmed.2021.685032 바로가기 바로가기 바로가기 바로가기
Article Swarm and evolutionary algorithms for energy disaggregation: challenges and prospects Energy disaggregation is defined as the process of estimating the individual electrical appliance energy consumption of a set of appliances in a house from the aggregated measurements taken at a single point or limited points. The energy disaggregation problem can be modelled both as pattern recognition problem and as an optimisation problem. Among the two, the pattern recognition problem has been considerably explored while the optimisation problem has not been explored to the potential. In literature, researchers have attempted to solve the problem using various optimisation algorithms including swarm and evolutionary algorithms. However, the focus on optimisation-based methodologies, in general, swarm and evolutionary algorithm-based methodologies in particular is minimal. By considering the different problem formulations in the literature, we propose a framework to solve the energy disaggregation problem with swarm and evolutionary algorithms. With the help of simulation results using the existing problem formulations, we discuss the challenges posed by the energy disaggregation to swarm and evolutionary algorithm-based methodologies and analyse the prospects of these algorithms for the problem of energy disaggregation with some future directions. Ghorbanpour, Samira; Pamulapati, Trinadh; Mallipeddi, Rammohan Kyungpook Natl Univ, Sch Elect Engn, Daegu 702701, South Korea Mallipeddi, Rammohan/AAL-5306-2020; Pamulapati, Trinadh Reddy/AAC-5277-2021 57207109590; 57195281873; 25639919900 samira.ghorbanpour@gmail.com;trinadhpamulapati@gmail.com;mallipeddi.ram@gmail.com; INTERNATIONAL JOURNAL OF BIO-INSPIRED COMPUTATION INT J BIO-INSPIR COM 1758-0366 1758-0374 17 4 SCIE COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;COMPUTER SCIENCE, THEORY & METHODS 2021 3.295 30.5 0.94 2025-07-30 11 13 energy disaggregation; swarm and evolutionary algorithms LOAD; RECOGNITION Energy disaggregation; Swarm and evolutionary algorithms Evolutionary algorithms; Optimization; Pattern recognition; Disaggregation; Electrical appliances; Energy; Energy disaggregation; Energy-consumption; Optimization problems; Pattern recognition problems; Problem formulation; Single point; Swarm and evolutionary algorithm; Energy utilization English 2021 2021 바로가기 바로가기 바로가기 바로가기
Article Optimal placement and sizing of FACTS devices for optimal power flow in a wind power integrated electrical network Optimal power flow (OPF) is one of the challenging optimization problems in power domain. The complexity of the problem escalates with incorporation of uncertain and intermittent renewable sources into the electrical network. Flexible AC transmission system (FACTS) devices are also becoming more commonplace in modern power system to mitigate growing demand and to relieve congestion from the network. This paper aims to solve the OPF where the generation cost is optimized with incorporation of stochastic wind power and several types of FACTS devices such as static VAR compensator, thyristor-controlled series compensator and thyristor-controlled phase shifter. Case studies with both fixed and uncertain load demands are performed. The stochastic wind energy and load demand are modeled using suitable probability density functions. Optimization objective considers cost of thermal generation, direct cost of scheduled wind power, penalty cost for underestimation and reserve cost for overestimation of the wind power. In addition, both locations and ratings of the FACTS devices are optimized to minimize total generation cost of the system. Success history-based adaptive differential evolution (SHADE), a powerful evolutionary algorithm, is adopted to perform the optimization task. The constraints of OPF problem are handled using superiority of feasible solutions (SF) method. The integration approach of SF method with several popular metaheuristic algorithms has been proposed in this work, and a detailed comparative analysis among various algorithms establishes SHADE algorithm to be the best performer. Biswas, Partha P.; Arora, Parul; Mallipeddi, R.; Suganthan, P. N.; Panigrahi, B. K. Adv Digital Sci Ctr, Singapore, Singapore; Indian Inst Technol, Delhi, India; Kyungpook Natl Univ, Daegu, South Korea; Nanyang Technol Univ, Singapore, Singapore Mallipeddi, Rammohan/AAL-5306-2020; Panigrahi, Bijaya/G-1005-2010; Arora, Parul/AAD-1707-2021; Biswas, P/F-6696-2019; Suganthan, Ponnuthurai/A-5023-2011 57194043616; 57215358810; 25639919900; 7003996538; 25637555100 partha.b@adsc-create.edu.sg;parularora@ee.iitd.ac.in;mallipeddi@knu.ac.kr;epnsugan@ntu.edu.sg;bkpanigrahi@ee.iitd.ac.in; NEURAL COMPUTING & APPLICATIONS NEURAL COMPUT APPL 0941-0643 1433-3058 33 12 SCIE COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE 2021 5.102 30.7 4.73 2025-07-30 78 102 Optimal power flow; Wind power; FACTS devices; Uncertain load demand; Adaptive differential evolution DIFFERENTIAL EVOLUTION ALGORITHM; INCORPORATING STOCHASTIC WIND; OPTIMAL LOCATION-ALLOCATION; SYSTEM; DISPATCH; LOAD; UNCERTAINTIES; OPTIMIZATION Adaptive differential evolution; FACTS devices; Optimal power flow; Uncertain load demand; Wind power Acoustic generators; Electric load flow; Electric network parameters; Evolutionary algorithms; Optimization; Probability density function; Static Var compensators; Stochastic systems; Thyristors; Wind power; Adaptive differential evolutions; Comparative analysis; Integration approach; Meta heuristic algorithm; Optimal placement and sizings; Optimization problems; Thyristor controlled phase shifters; Thyristor controlled series compensator; Flexible AC transmission systems English 2021 2021-06 10.1007/s00521-020-05453-x 바로가기 바로가기 바로가기 바로가기
Article Comparative analysis of laser and simulated speckle pattern for single shot 3D reconstruction Stereo photogrammetry is a fundamental technique for 3D measurements in different applications. As passive stereo methods struggle in texture-less regions, different light-coded patterns are projected to solve the correspondence problem. When the reconstruction method requires a series of sequentially coded light patterns, the system is prone to movement-related errors. A single pattern is utilized where the potential subjects are dynamic or change the position rapidly. A random speckle pattern is a good candidate for such systems. Primarily, there are two approaches to generate the speckle pattern in stereoscopic systems. The speckles can be generated by the coherent illumination of a laser diode, and the laser speckle-like pattern can also be simulated and projected by a professional projector. The purpose of both is to solve the stereo correspondence problem; however, the performance of both can differ, subjective to employed 3D sensing algorithm. In this Letter, we compare the performance of both for single-shot 3D reconstruction. We have discussed the pros and cons of both methods and analyze their ability to resolve long range 3D reconstruction. Khan, Danish; Kim, Min Young Kyungpook Natl Univ, Sch Elect Engn, IT Coll, 1370 Sankyuk Dong, Daegu 702701, South Korea; Kyungpook Natl Univ, Res Ctr Neurosurg Robot Syst, 1370 Sankyuk Dong, Daegu 702701, South Korea Khan, Danish/AAW-6708-2021 57200212320; 56739349100 minykim@knu.ac.kr; APPLIED PHYSICS LETTERS APPL PHYS LETT 0003-6951 1077-3118 119 13 SCIE PHYSICS, APPLIED 2021 3.971 30.8 0.1 2025-07-30 2 2 SHAPE MEASUREMENT; PROJECTION Image reconstruction; Stereo image processing; Textures; 3-D measurement; 3D reconstruction; Comparative analyzes; Correspondence problems; Passive stereo; Performance; Single-shot; Speckle patterns; Stereo method; Stereophotogrammetry; Speckle English 2021 2021-09-27 10.1063/5.0056326 바로가기 바로가기 바로가기 바로가기
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