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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | The Geometric Mean of Min Matrices | In this paper, we consider the geometric mean of min matrices. We establish a closed form for the geometric mean of two positive definite min matrices. We further show that the set of min matrices is geodesically convex in the Cartan-Hadamard manifold of positive definite matrices. We also present monotonic one-parameter families of min matrices. | Shin, Byeong-Chun; Lim, Yongdo; Choi, Hayoung | Chonnam Natl Univ, Dept Math, Gwangju 61186, South Korea; Sungkyunkwan Univ, Dept Math, Suwon 16419, South Korea; Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea | 59936166200; 55931749600; 56942685000 | bcshin@chonnam.ac.kr; ylim@skku.edu; hayoung.choi@knu.ac.kr; | TAIWANESE JOURNAL OF MATHEMATICS | TAIWAN J MATH | 1027-5487 | 2224-6851 | 29 | 3 | SCIE | MATHEMATICS | 2024 | 0.6 | 58.3 | N/A | 0 | 0 | positive definite matrix; min matrix; Karcher mean; tridiagonal matrix | Karcher mean; min matrix; positive definite matrix; tridiagonal matrix | English | 2025 | 2025-06 | 10.11650/tjm/250101 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | Article | EpCAM and CD24 specific EVRNA analysis for ovarian cancer diagnosis | Extracellular vesicles (EVs) are recently emerged as biomarkers for cancer diagnosis. RNA in EV specifically has drawn attention for its high stability and accuracy for early cancer diagnosis. However, analysis of EV RNA in plasma for cancer diagnosis often can be limited by a low population of cancer-derived EVs in the plasma samples. Herein, we developed a sensitive EV RNA analysis technique with protein-specific EV enrichment for accurate ovarian cancer diagnosis. © 2025 The Author(s). Bulletin of the Korean Chemical Society published by Korean Chemical Society and Wiley-VCH GmbH. | Kim, Yejin; Hyun, Da Han; Lee, Yoon Hee; Lim, Woojeong; Lee, Hoyeon; Lee, Soyeon; Jang, Hyeon-Ki; Lim, Joohyun; Hong, Dae Gy; Park, Jun Seok; Park, Soo Yeun; Park, Jongmin | Department of Biomedical Science, School of Medicine, Kyungpook National University, Daegu, South Korea, Colorectal Cancer Center, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Biomedical Science, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Obstetrics and Gynecology, School of Medicine, Kyungpook National University, Daegu, South Korea, Department of Obstetrics and Gynecology, Kyungpook National University Chilgok Hospital, Daegu, South Korea; Department of Chemistry, Kangwon National University, Chuncheon, South Korea; Department of Chemistry, School of Physics and Chemistry, Gwangju Institute of Science and Technology (GIST), Gwangju, South Korea; Multidimensional Genomics Research Center, Kangwon National University, Chuncheon, South Korea, Institute for Molecular Science and Fusion Technology, Kangwon National University, Chuncheon, South Korea; Multidimensional Genomics Research Center, Kangwon National University, Chuncheon, South Korea, Division of Chemical Engineering and Bioengineering, College of Art Culture and Engineering, Kangwon National University, Chuncheon, South Korea; Department of Chemistry, Kangwon National University, Chuncheon, South Korea, Multidimensional Genomics Research Center, Kangwon National University, Chuncheon, South Korea, Institute for Molecular Science and Fusion Technology, Kangwon National University, Chuncheon, South Korea; Department of Obstetrics and Gynecology, Kyungpook National University Chilgok Hospital, Daegu, South Korea; Department of Biomedical Science, School of Medicine, Kyungpook National University, Daegu, South Korea, Colorectal Cancer Center, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea; Colorectal Cancer Center, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Chemistry, Kangwon National University, Chuncheon, South Korea, Multidimensional Genomics Research Center, Kangwon National University, Chuncheon, South Korea, Institute for Molecular Science and Fusion Technology, Kangwon National University, Chuncheon, South Korea | 59958260300; 58089142700; 59681678900; 57824267700; 57209416447; 59136312900; 46661885000; 7403454017; 26656670100; 35226761100; 59908460400; 57217845765 | parkjs0802@knu.ac.kr; yeun21c@knu.ac.kr; jpark@kangwon.ac.kr; | Bulletin of the Korean Chemical Society | B KOREAN CHEM SOC | 0253-2964 | 1229-5949 | SCIE | CHEMISTRY, MULTIDISCIPLINARY | 2024 | 2.2 | 58.4 | 0 | extracellular vesicle; immunomagnetic enrichment; miRNA; ovarian cancer | Diagnosis; Diseases; Cancer diagnosis; Early cancer; Extracellular; Extracellular vesicle; Immunomagnetic; Immunomagnetic enrichment; MiRNA; Ovarian cancer diagnosis; Ovarian cancers; Plasma samples; RNA | English | Article in press | 2025 | 10.1002/bkcs.70041 | 바로가기 | 바로가기 | 바로가기 | |||||||||||
| ○ | ○ | Article | Influence of SARS-CoV-2 omicron variant infection on seizure occurrence among children: The large-scale multicenter study | Purpose: During the pandemic of the coronavirus disease 2019 (COVID-19) Omicron variant, we experienced an increase in patients with COVID-19-associated seizures. However, there was a lack of literature about the occurrence of seizures according to different pandemics. Therefore, we investigated the characteristics of seizures in pediatric patients before and after the spread of the Omicron variant. Method: We analyzed the clinical findings of pediatric patients who visited outpatient clinics or emergency rooms and were diagnosed with COVID-19 at seven hospitals in Korea from 2020 to 2022. We divided the participants into pre-Omicron and post-Omicron groups based on whether it was before or after January 1, 2022, the onset of the Omicron variant pandemic in Korea. We then compared seizure incidence and clinical characteristics between the two groups. Result: We enrolled 1608 patients aged 5.2 +/- 4.8 years. Among post-Omicron group (n = 1293), 286 (22 %) patients presented with COVID-19-associated seizures; in contrast, only one (0.3 %) patient in pre-Omicron group (n = 315). Status epilepticus occurred in 18 (6.2 %) patients, multiple seizures in 64 (22 %), and afebrile seizures in 33 (11.5 %). Clinical diagnoses of seizures were seizures associated with COVID-19 infection (239/286, 83.6 %), epilepsy (39/286, 13.6 %), neuroinflammatory disease (4/286, 1.4 %), seizures associated with multisystem inflammatory syndrome in children (MIS-C, 4/286, 1.4 %), and hyponatremic seizures (1/286, 0.3 %). Conclusion: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron variant is associated with a high incidence of seizure as a presenting symptom. Clinical diagnoses vary, including seizures associated with the SARS-CoV-2 omicron variant without a definitive diagnosis, epilepsy, MIS-C, neuroinflammatory disease, and hyponatremia. | Kong, Juhyun; Lyu, Sooyoung; Nam, Sang Ook; Kim, Young Ok; Ahn, Ji-ye; Yeom, Jung Sook; Lee, Sun Ho; Kim, Kyung-Ran; Lee, Bo Lyun; Hur, Yun Jung; Han, Young Joo; Hwang, Su-Keong; Lee, Yun-Jin | Pusan Natl Univ, Dept Pediat, Childrens Hosp, Yangsan, South Korea; Pusan Natl Univ, Sch Med, Yangsan, South Korea; Pusan Natl Univ, Yangsan Hosp, Res Inst Convergence Biomed Sci & Technol, Yangsan, South Korea; Chonnam Natl Univ Hosp, Dept Pediat, Gwangju, South Korea; Chosun Univ Hosp, Dept Pediat, Gwangju, South Korea; Gyeongsang Natl Univ Hosp, Dept Pediat, Jinju, South Korea; Gyeongsang Natl Univ, Changwon Hosp, Dept Surg, Chang Won, South Korea; Inje Univ, Busan Paik Hosp, Dept Pediat, Busan, South Korea; Inje Univ, Haeundae Paik Hosp, Dept Pediat, Busan, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Pediat, Daegu, South Korea | 57203547871; 56785463800; 36461383000; 57192207814; 57289813200; 56046032700; 57192542488; 57190005709; 24553938600; 36637334200; 59708480900; 57204321861; 55786639400 | jinnyeye@naver.com; | BRAIN & DEVELOPMENT | BRAIN DEV-JPN | 0387-7604 | 1872-7131 | 47 | 3 | SCIE | CLINICAL NEUROLOGY;PEDIATRICS | 2024 | 1.3 | 58.4 | 0 | 2025-05-07 | 0 | 0 | Seizure; COVID19; SARS-CoV-2; Omicron | COVID19; Omicron; SARS-CoV-2; Seizure | Child; Child, Preschool; COVID-19; Female; Humans; Incidence; Infant; Male; Republic of Korea; SARS-CoV-2; SARS-CoV-2 variants; Seizures; diazepam; levetiracetam; lorazepam; midazolam; phenobarbital; phenytoin; afebrile seizure; Arnold Chiari malformation; Article; birth weight; brain atrophy; central nervous system disease; cerebellum atrophy; cerebellum hypoplasia; cerebral palsy; child; continuous infusion; contrast enhancement; controlled study; coronavirus disease 2019; developmental delay; disease association; electroencephalogram; epilepsy; epileptic discharge; epileptic state; female; fever; hospitalization; human; hyponatremia; incidence; infant; inflammation; Korea; major clinical study; male; multicenter study; myelination; neoplasm; nervous system inflammation; neurologic disease; nuclear magnetic resonance imaging; pandemic; pediatric multisystem inflammatory syndrome; pediatric patient; pneumonia; polymerase chain reaction; SARS-CoV-2 Omicron; seizure; seizure duration; clinical trial; complication; epidemiology; etiology; preschool child; seizure; Severe acute respiratory syndrome coronavirus 2; South Korea | English | 2025 | 2025-06 | 10.1016/j.braindev.2025.104341 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | MRSF-TDDFT: A new tool in quantum chemistry for better understanding molecules and materials | Quantum chemical theories are essential tools for predicting the properties of complex quantum systems without the need for prior empirical data. While traditional theories have long dominated the field, their applicability is often limited in complex scenarios, particularly for systems involving excited states. Mixed-Reference Spin-Flip Time-Dependent Density Functional Theory (MRSF-TDDFT) addresses these challenges, offering a robust, accurate, and computationally efficient framework for studying both ground and excited states of large molecular systems. MRSF-TDDFT achieves predictive accuracy on par with much more computationally intensive quantum chemical methods. Notably, it successfully describes the doubly excited states, a limitation of conventional TDDFT, by naturally incorporating key doubly excited configurations within its response space. This capability also enables MRSF-TDDFT to accurately reproduce the correct asymptotic behavior of bond-breaking potential energy surfaces. Furthermore, it resolves critical photochemical features, such as the conical intersections, which elude both TDDFT and Complete Active Space Self-Consistent Field (CASSCF) methods. Despite its advanced predictive power, MRSF-TDDFT retains computational efficiency comparable to traditional TDDFT. With the development of custom-tailored functionals, its accuracy can be further enhanced, extending its potential applications. This innovation represents a significant advancement, empowering researchers to uncover intricate molecular behaviors and facilitate the design of novel materials with unprecedented precision. | Park, Woojin; Lee, Seunghoon; Komarov, Konstantin; Mironov, Vladimir; Nakata, Hiroya; Zeng, Tao; Huix-Rotllant, Miquel; Choi, Cheol Ho | Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Seoul Natl Univ, Dept Chem, Seoul, South Korea; Pohang Univ Sci & Technol, Ctr Quantum Dynam, Pohang, South Korea; Terra Quantum AG, St Gallen, Switzerland; Kyoto Univ, Fukui Inst Fundamental Chem, Kyoto, Japan; York Univ, Dept Chem, Toronto, ON, Canada; Aix Marseille Univ, CNRS, ICR, Marseille, France | Lee, Seunghoon/AAB-4846-2021; Huix-Rotllant, Miquel/S-8914-2019; Huix-Rotllant, Miquel/J-3291-2016 | 57223952329; 57194591254; 57193073953; 16203310700; 55305767500; 58038551800; 25634188900; 57940570600 | cchoi@knu.ac.kr; | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | B KOREAN CHEM SOC | 0253-2964 | 1229-5949 | 46 | 4 | SCIE | CHEMISTRY, MULTIDISCIPLINARY | 2024 | 2.2 | 58.4 | 0 | 2025-05-07 | 0 | 0 | excited state; ground state; MRSF-TDDFT; nonadiabatic; quantum chemistry | DENSITY-FUNCTIONAL THEORY; ELECTRON-AFFINITIES; EXCITED-STATES; ENERGY-LEVELS; SPECTROSCOPY; CARBON | excited state; ground state; MRSF-TDDFT; nonadiabatic; quantum chemistry | Complexation; Molecular docking; Molecular mechanics; Quantum optics; Spin dynamics; Chemical theories; Complex quantum systems; Empirical data; Excited-states; Mixed-reference spin-flip time-dependent density functional theory; Non-adiabatic; Property; Quantum chemical; Spin flip time; Time dependent density functional theory; Molecules | English | 2025 | 2025-04 | 10.1002/bkcs.70011 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Non-targeted metabolite profiling reveals biochemical diversity of three East Asian mosses | Mosses are known for their rich diversity in bioactive compounds and their essential role in maintaining ecosystems. While genetic and metabolomics studies have been conducted on some model species, research on comprehensive metabolomics of common mosses in East Asia remains limited. In this study, we conducted an untargeted analysis of three East Asian moss species, Niphotrichum japonicum, Calohypnum plumiforme, and Polytrichum formosum, by ultrasonic-assisted extraction and liquid chromatography coupled with high-resolution mass spectrometry. This approach facilitated the detailed profiling and compound classification through reference databases. Tandem mass spectrometry with positive mode tentatively identified 188, 183, and 186 metabolites, respectively, with lipids and terpenoids as the predominant class. Among these, 25 potential biomarkers were identified to differentiate between species. Multivariate analysis, including principal component analysis, revealed distinct metabolic profiles for each species, representing taxonomical differences, confirming data reproducibility, and clear species differentiation. Enrichment analysis further highlighted the upregulation of unsaturated fatty acid biosynthesis across all moss species. This is the first report utilizing an untargeted metabolomics approach with chemometrics to differentiate moss species cultivated in the same location, offering a new foundation for studying the metabolic responses of East Asian mosses. | Zahra, Fatima Tuz; Min, Kyungwon; Lee, Jungeun; Jung, Maeng-Joon; Lee, Hyoungseok; Kim, Sunghwan | Kyungpook Natl Univ, Dept Chem, 80 Daehak Ro, Daegu 41566, South Korea; Korea Polar Res Inst, Div Life Sci, Incheon 21990, South Korea; Kyungpook Natl Univ, Mass Spectrometry Based Convergence Res Inst, Daegu, South Korea; Green Nano Mat Res Ctr, Daegu, South Korea | ; Kim, Sunghwan/HKN-9812-2023 | 58627102400; 56051297100; 57206732355; 56291394700; 57216148355; 57203772967 | soulaid@kopri.re.kr; sunghwank@knu.ac.kr; | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | B KOREAN CHEM SOC | 0253-2964 | 1229-5949 | 46 | 6 | SCIE | CHEMISTRY, MULTIDISCIPLINARY | 2024 | 2.2 | 58.4 | 0 | 2025-06-11 | 0 | 0 | bryophytes; metabolite profiling; multivariate data analysis; non-targeted analysis; UPLC-Q-cIM-TOF-MS | BIOSYNTHESIS; ARABIDOPSIS; BOREAL; SOIL | bryophytes; metabolite profiling; multivariate data analysis; non-targeted analysis; UPLC-Q-cIM-TOF-MS | Discriminant analysis; High performance liquid chromatography; High pressure liquid chromatography; Inductively coupled plasma mass spectrometry; Metabolites; Taxonomies; Bioactive compounds; Bryophyte; Metabolite profiling; Metabolomics; Moss species; Multivariate data analysis; Non-targeted; Non-targeted analyze; Targeted metabolite profiling; UPLC-Q-cIM-TOF-MS; Biomarkers | English | 2025 | 2025-06 | 10.1002/bkcs.70032 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Editorial Material | Rethinking the diagnostic value of thymic CT in ocular myasthenia gravis | Seok, Hung Youl | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Neurol, 130 Dongdeok Ro, Daegu 41944, South Korea | Seok, Hung Youl/HZI-4365-2023 | 24472118000 | shy2354@gmail.com; | ACTA NEUROLOGICA BELGICA | ACTA NEUROL BELG | 0300-9009 | 2240-2993 | 125 | 3 | SCIE | CLINICAL NEUROLOGY;NEUROSCIENCES | 2024 | 2.1 | 58.4 | 0 | 2025-05-07 | 0 | 0 | corticosteroid; computer assisted tomography; controlled study; demographics; diagnostic test accuracy study; diagnostic value; electromyography; electrophysiology; human; Letter; myasthenia gravis; nerve stimulation; ocular myasthenia gravis; patient selection; thymus; thymus hyperplasia; diagnosis; letter; myasthenia gravis | English | 2025 | 2025-06 | 10.1007/s13760-024-02716-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | Article | Cloning and Expression Studies of Osmotin-Like Protein Gene from Solanum nigrum in Escherichia coli | Plants face various biotic and abiotic stresses, necessitating the activation of defense mechanisms, including pathogenesis-related (PR) proteins. Osmotin-like proteins (OLPs), belonging to the PR-5 family, play a crucial role in plant defense by enhancing resistance to pathogens and environmental stresses. However, the functional characterization of OLPs remains limited. This study aimed to clone and express the OLP gene from the medicinal plant Solanum nigrum in Escherichia coli to facilitate further functional and structural analyses. The genomic DNA of S. nigrum was isolated from in vitro-cultured plants, and the OLP gene was amplified using primers designed via Primer3 software based on NCBI sequences. Gradient PCR optimization determined the optimal annealing temperature between 58.3 °C and 60 °C. The amplified gene was cloned into the pTZ57R/T vector and transformed into E. coli. Sequencing confirmed a 98% homology with reported OLP sequences. For expression analysis, the gene was subcloned into the expression vector pET15b and transformed into E. coli BL21 (DE3). Induction with 1 mM IPTG at 37 °C for 3 h resulted in the production of a 26 kDa protein, confirmed by SDS-PAGE and Protein Dot Blot analysis using anti-histidine antibodies. The successful cloning and expression of OLP provide a foundation for investigating its role in plant-pathogen interactions and its potential applications in agriculture and medicine. This study contributes to understanding PR proteins and offers insights into their potential for enhancing stress tolerance in crops. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025. | Saleem, Muhammad Zafar; Arshad, Fatima; Ahmad, Nauman; Iftikhar, Muhammad; Saleem, Ammara; Jahangir, Ghulam Zahra; Zulfiqar, Asma; Arshed, Muhammad Zeeshan; Shah, Anis Ali; Shaffique, Shifa; Gatasheh, Mansour K. | Centre for Applied Molecular Biology (CAMB), University of the Punjab, Lahore, Pakistan; Centre for Applied Molecular Biology (CAMB), University of the Punjab, Lahore, Pakistan; Centre for Applied Molecular Biology (CAMB), University of the Punjab, Lahore, Pakistan; Division of Science and Technology (DSnT), Department of Botany, University of Education Lahore, Main Campus, Lahore, Pakistan, Department of Botany, Division of Science and Technology, University of Education, Lahore, Pakistan; Institute of Botany, University of the Punjab Lahore, Lahore, Pakistan; Centre for Applied Molecular Biology (CAMB), University of the Punjab, Lahore, Pakistan; Institute of Botany, University of the Punjab Lahore, Lahore, Pakistan; Institute of Botany, University of the Punjab Lahore, Lahore, Pakistan; Division of Science and Technology (DSnT), Department of Botany, University of Education Lahore, Main Campus, Lahore, Pakistan; School of Applied Biosciences, College of Agriculture & Life Science, Kyungpook National University, 80 Daehak-ro, Buk-Gu, Daegu, 41566, South Korea; Department of Biochemistry, College of Science, King Saud University, P.O.Box 2455, Riyadh, 11451, Saudi Arabia | 57217312133; 59820141300; 57222544572; 59875899600; 35196904800; 36982858600; 43462229700; 57669695500; 57211606140; 57203898867; 15742571400 | Iftikharf12m38@gmail.com; anisalibot@gmail.com; | Molecular Biotechnology | MOL BIOTECHNOL | 1073-6085 | 1559-0305 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 2.5 | 58.5 | 0 | 2025-06-11 | 0 | E. coli strain; OLP gene; Pathogenesis related proteins (PR); PCR; Solanum nigrum | Algae; Fungi; Gene encoding; Transcription; Vegetation; Biotic and abiotic stress; Cloning and expression; E coli strain; E. coli; Osmotin-like protein gene; Pathogenesis related protein; Pathogenesis-related proteins; PCR; Protein genes; Solanum nigrum; Pathogens | English | Article in press | 2025 | 10.1007/s12033-025-01448-y | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | Article | Decoding the Chloroplast Genome of Korean endemic plant Acer okamotoanum: Comparative Genomics, Phylogenetic Insights, and Potential for Marker Development | Acer okamotoanum, a medicinally significant endemic plant of Korea, has seen limited genomic research. To address this gap, we conducted a comprehensive sequencing and analysis of its chloroplast genome. The assembled genome is 156,242 bp in length, with typical quadripartite structure, consisting of a large single-copy region, a small single-copy region, and two inverted repeat regions. It contains 130 genes, including 85 protein-coding, 37 tRNA, and 8 rRNA genes. Sixteen genes have a single intron, while clpP and ycf3 possess two introns each. Additionally, 17 genes are duplicated within the inverted repeat regions. The genome analysis revealed 92 Simple Sequence Repeats (SSRs), predominantly located in intergenic regions, with a bias toward A/T-rich codons. Comparative analysis with five closely related Acer species highlighted a highly conserved genomic structure, but also revealed differences in SSRs and repeat sequences. Hypervariable regions, such as rpl32-trnL and ycf1, were identified as potential molecular markers for phylogenetic and population studies. Phylogenetic analysis involving 37 chloroplast genomes confirmed the monophyly of the Acer genus and placed A. okamotoanum within the Platanoidea section, closely related to A. truncatum. This study improves the understanding of A. okamotoanum’s genomic structure, offering insights for phylogenetic analysis, marker development, and conservation efforts. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025. | Kadam, Suhas K.; Tamboli, Asif S.; Youn, Jin-Suk; Pak, Jae Hong; Choo, Yeon-Sik | Department of Agricultural Biotechnology, National Institute of Agricultural Sciences, Rural Development Administration, Jeollabuk-Do, Jeonju-Si, South Korea; Research Institute for Dok-Do and Ulleung-Do Island, Kyungpook National University, 80 Daehak-Ro, Buk-Gu, Daegu, 41566, South Korea; Research Institute for Dok-Do and Ulleung-Do Island, Kyungpook National University, 80 Daehak-Ro, Buk-Gu, Daegu, 41566, South Korea; Research Institute for Dok-Do and Ulleung-Do Island, Kyungpook National University, 80 Daehak-Ro, Buk-Gu, Daegu, 41566, South Korea; Research Institute for Dok-Do and Ulleung-Do Island, Kyungpook National University, 80 Daehak-Ro, Buk-Gu, Daegu, 41566, South Korea, Department of Biology, School of Life Sciences, Kyungpook National University, 80 Daehak-Ro, Buk-Gu, Daegu, 41566, South Korea | 57188723669; 56974034100; 57210840807; 7102232932; 26040458100 | yschoo@knu.ac.kr; | Molecular Biotechnology | MOL BIOTECHNOL | 1073-6085 | 1559-0305 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 2.5 | 58.5 | 0 | 2025-05-07 | 0 | Acer okamotoanum; Chloroplast genome; Comparative genomics; Phylogeny; Ulleungdo Island | Abiotic; Anthropogenic; Biotic; Invertebrates; Plant diseases; Acer okamotoanum; Chloroplast genome; Comparative genomics; Endemic plants; Genomic structure; Inverted repeat; Marker development; Phylogeny; Simple sequence repeats; Ulleungdo island; Genome | English | Article in press | 2025 | 10.1007/s12033-025-01383-y | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Clinical efficacy of 0.1% cyclosporine A in dry eye patients with inadequate responses to 0.05% cyclosporine A: a switching, prospective, open-label, multicenter study | Purpose To assess the clinical efficacy of 0.1% cyclosporine A (CsA) in dry eye patients who have shown inadequate responses to previous treatment with 0.05% CsA. Design This study was designed as a switching, prospective, multicenter, 12-week, open-label study. Methods Patients with dry eye disease (DED), who experienced inadequate responses to at least 3 months of treatment with 0.05% cyclosporine, were enrolled in this study. Clinical evaluations included the National Eye Institute (NEI) corneal and conjunctival staining scores, tear film break-up time (TF-BUT), Symptom Assessment in Dry Eye (SANDE), ocular discomfort scale (ODS), and tear volume. These parameters were assessed at baseline, and again at 4, 8, and 12 weeks after switching to 0.1% CsA. Results Ninety-one patients were enrolled in the study, and 70 patients completed the trial. Statistical analysis was performed on the full analysis set (FAS) using the Markov Chain Monte Carlo (MCMC) method to account for missing data. After switching to 0.1% CsA, subjective symptoms assessed by the Symptom Assessment in Dry Eye (SANDE) and Ocular Discomfort Scale (ODS) showed improvement (p < 0.0001). Objective signs of dry eye, including the National Eye Institute (NEI) score, tear film break-up time (TF-BUT), and tear volume also improved (p < 0.0001). Conclusions In patients with dry eye disease (DED) who exhibited inadequate responses to 0.05% cyclosporine A (CsA), switching to 0.1% CsA resulted in significant improvements in both subjective symptoms and objective clinical signs. This finding suggests that higher concentrations of CsA may be more effective in treating individuals with moderate to severe DED. | Yoon, Sook Hyun; Kim, Eun Chul; You, In-Cheon; Choi, Chul Young; Kim, Jae Yong; Song, Jong Suk; Hyon, Joon Young; Kim, Hong Kyun; Seo, Kyoung Yul | Daegu Catholic Univ Med, Dept Ophthalmol, Daegu, South Korea; Catholic Univ Korea, Bucheon St Marys Hosp, Coll Med, Dept Ophthalmol, Bucheon, South Korea; Jeonbuk Natl Univ, Med Sch, Dept Ophthalmol, Jeonju, South Korea; Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Ophthalmol, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Ophthalmol, Seoul, South Korea; Korea Univ, Coll Med, Dept Ophthalmol, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Ophthalmol, Seongnam, South Korea; Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, Daegu, South Korea; Yonsei Univ, Coll Med, Inst Vis Res, Dept Ophthalmol, Seoul, South Korea | ; Hyon, Joon/J-5720-2012; Seo, Kyoung/I-5484-2019; , James/ABG-8160-2020 | 57222323711; 25625082600; 16644134200; 14522006600; 15923054800; 7404786554; 58914643400; 57218260940; 7201839260 | okeye@knu.ac.kr; SEOKY@yuhs.ac; | BMC OPHTHALMOLOGY | BMC OPHTHALMOL | 1471-2415 | 25 | 1 | SCIE | OPHTHALMOLOGY | 2024 | 1.7 | 58.7 | 0 | 2025-05-07 | 0 | 0 | Dry eye disease; Cyclosporine A; Cationic emulsion; Switching; Multicenter study | CATIONIC EMULSION; DISEASE; SAFETY; BENEFITS; THERAPY | Cationic emulsion; Cyclosporine A; Dry eye disease; Multicenter study; Switching | Adult; Aged; Cyclosporine; Drug Substitution; Dry Eye Syndromes; Female; Humans; Immunosuppressive Agents; Male; Middle Aged; Ophthalmic Solutions; Prospective Studies; Tears; Treatment Outcome; cyclosporine; eye drops; immunosuppressive agent; adult; aged; clinical trial; drug substitution; drug therapy; dry eye syndrome; female; human; lacrimal fluid; male; metabolism; middle aged; multicenter study; physiology; prospective study; treatment outcome | English | 2025 | 2025-01-22 | 10.1186/s12886-025-03862-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Histone H3 lysine 9 tri-methylation is associated with pterygium | BackgroundPterygium, abnormal growths of conjunctival tissue onto the cornea, are common ocular surface conditions with a high risk of recurrence after surgery and potential ophthalmic complications. The exact cause of pterygium remains unclear, and the triggers are still unknown. This study aims to investigate the relationship between pterygium and epigenetics to uncover the cause of pterygium and identify biomarkers for its diagnosis.MethodsWe performed a ChIP-seq assay to compare genome-wide histone modification levels between normal conjunctiva and stage 3 pterygium samples.ResultsIn this study, we investigate the epigenetic profiles of patients with pterygium, focusing on histone H3 lysine 4 (H3K4) and lysine 9 (H3K9) trimethylation (me3). While H3K4me3 levels showed no significant genome-wide change, they were significantly altered in genes related to development and ocular diseases. Conversely, H3K9me3 levels were markedly elevated genome-wide, particularly at the promoters of 82 genes involved in developmental pathways. Furthermore, we identify six genes, ANK2, AOAH, CBLN2, CDH8, CNTNAP4, and DPP6, with decreased gene expression correlated with substantially increased H3K9me3, suggesting their potential as biomarkers for pterygium.ConclusionThis study represents the first report linking histone modification to pterygium progression, providing valuable insights into therapeutic strategies and potential drug targets. | Choi, Dahee; Na, Ann-Yae; Jeoung, Seok-Won; Choi, Yun-Hee; Park, Nayoon; Park, Hyun-Sun; Kwon, Hyuk-Kwon; Lee, Hyun-Shik; Cho, Dong-Hyung; Kim, Dong Hyun; Ryu, Hong-Yeoul | Kyungpook Natl Univ, KNU Inst Basic Sci, Coll Nat Sci, Sch Life Sci,KNU G LAMP Project Grp,BK21 FOUR KNU, Daegu 41566, South Korea; Korea Univ, Dept Ophthalmol, Coll Med, 73,Goryeodae Ro, Seoul 02841, South Korea; Korea Univ, Sch Hlth & Environm Sci, Seoul, South Korea; Chonnam Natl Univ, Dept Pharmacol, Med Sch, Jeonnam 58128, South Korea; Gyeongsang Natl Univ, Div Bio & Med Bigdata Dept, Program BK4, Div Life Sci, Jinju 52828, South Korea | kwon, hyuk-kwon/AAS-4154-2021 | 59135735300; 57201530058; 57822770000; 57192687511; 59405747900; 58804766900; 37009030900; 59858434400; 58950702200; 57223712473; 55889917800 | amidfree@gmail.com; rhr4757@knu.ac.kr; | BMC OPHTHALMOLOGY | BMC OPHTHALMOL | 1471-2415 | 25 | 1 | SCIE | OPHTHALMOLOGY | 2024 | 1.7 | 58.7 | 0 | 2025-05-07 | 0 | 0 | Pterygium; Histone modification; Development; Biomarker | GENE-EXPRESSION; DNA METHYLATION; PROMOTER HYPERMETHYLATION; GROWTH-FACTOR; PATHOGENESIS; SUMOYLATION; EPIGENETICS; RECURRENCE; ROLES | Biomarker; Development; H3K4me3; H3K9me3; Histone modification; Pterygium | Adult; Aged; Biomarkers; Conjunctiva; Epigenesis, Genetic; Female; Histones; Humans; Lysine; Male; Methylation; Middle Aged; Pterygium; biological marker; histone; lysine; adult; aged; conjunctiva; diagnosis; female; genetic epigenesis; genetics; human; male; metabolism; methylation; middle aged; pathology; pterygium | English | 2025 | 2025-03-03 | 10.1186/s12886-025-03939-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | 1D Network computational fluid dynamics for evaluating regional pressures in subjects with cement dust exposure | Cement dust is a primary contributor to air pollution and is responsible for causing numerous respiratory diseases. The impact of cement dust exposure on the respiratory health of residents is increasing owing to the demand for construction associated with urbanization. Long-term inhalation of cement dust leads to a reduction in lung function, alterations in airway structure, increased inhalation and exhalation resistance, and heightened work of breath. In this study, we investigated the effects of cement dust exposure on lung function based on the pulmonary function test (PFT) and one-dimensional computational fluid dynamics (1D CFD). Statistical tests were performed to address the disparity of airway function between healthy and cement dust-exposed participants. The percent predicted values of forced vital capacity percent (FVC%) and forced expiratory volume in 1 s (FEV1%) were found to be decreased in the group of dust-exposed participants. An elevation of regional pressure variation was found in cement dust-exposed airways during both inhalation and exhalation that was associated with alternations of airway structural features therein. The 1D CFD model is beneficial for a cost-effective estimation of airway regional pressure and provides valuable insights for more precise diagnosis and treatment planning in individuals exposed to cement dust. | Tran, Minh Tam; Nguyen, Quoc Hung; Cui, Xinguang; Chae, Kum Ju; Kim, Sujeong; Yoo, Ji-Seung; Choi, Sanghun | Kyungpook Natl Univ & IEDT, Sch Mech Engn, 80 Daehak Ro, Daegu 41566, South Korea; Huazhong Univ Sci & Technol, Sch Aerosp Engn, Wuhan, Peoples R China; Jeonbuk Natl Univ, Biomed Res Inst Jeonbuk Natl Univ Hosp, Inst Med Sci, Dept Radiol,Res Inst Clin Med, Jeonju, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Allergy & Clin Immunol, Daegu, South Korea; Kyungpook Natl Univ, Sch Life Sci, FOUR KNU Creat BioRes Grp BK21, Daegu 41566, South Korea | Tran, Minh Tam/KDN-3469-2024; Yoo, Ji-Seung/KHD-6177-2024 | 58770600000; 58798508300; 50261346800; 57195310676; 36666447400; 59510752300; 55847101000 | s-choi@knu.ac.kr; | JOURNAL OF BIOMECHANICS | J BIOMECH | 0021-9290 | 1873-2380 | 180 | SCIE | BIOPHYSICS;ENGINEERING, BIOMEDICAL | 2024 | 2.4 | 58.9 | 0 | 2025-05-07 | 0 | 0 | Cement dust; Computed tomography; Computational fluid dynamics; Airway; Lung | PULMONARY-FUNCTION; WORKERS; MODEL; DROP; RESISTANCE; SYMPTOMS; INDUSTRY; HEALTH | Airway; Cement dust; Computational fluid dynamics; Computed tomography; Lung | Adult; Computer Simulation; Construction Materials; Dust; Female; Forced Expiratory Volume; Humans; Hydrodynamics; Inhalation Exposure; Lung; Male; Middle Aged; Models, Biological; Pressure; Respiratory Function Tests; Vital Capacity; Cements; Computational fluid dynamics; Dust; Pulmonary diseases; % reductions; Airway structures; Cement dust; Computational fluid; Computed tomography; Fluid-dynamics; Lung; Lung function; One-dimensional; Pulmonary function test; adult; aged; air pollution; Article; body mass; chronic obstructive lung disease; clinical article; cohort analysis; computational fluid dynamics; computer assisted tomography; controlled study; diagnostic test accuracy study; dust; dust exposure; exhalation; female; forced expiratory volume; forced vital capacity; functional residual capacity; hospitalization; human; human experiment; lung function; lung function test; lung lobe; male; middle aged; normal human; peak expiratory flow; smoking; treatment planning; very elderly; adverse event; biological model; building material; computer simulation; hydrodynamics; inhalational exposure; lung; pathophysiology; physiology; pressure; procedures; vital capacity; Lung cancer | English | 2025 | 2025-02 | 10.1016/j.jbiomech.2025.112501 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effect of Sb Doping on the Thermoelectric Properties of MNiSn (M=Ti, Zr, Hf) Half-Heusler Alloys Fabricated by a Rapid Solidification Process | Among half-Heusler alloys, MNiSn (M = Ti, Zr, Hf) compounds have been extensively investigated due to their unique crystal structure and promising thermoelectric properties. However, forming the MNiSn half-Heusler single phase directly during the solidification process is challenging, necessitating a prolonged annealing step for homogenization. Rapid Solidification Processing (RSP) was employed to synthesize materials with controlled microstructures and high thermoelectric performance within a short processing time. Optimized RSP processes were then used to produce ribbon-shaped samples, aiming to enhance thermoelectric performance through grain size reduction and the synthesis of half-Heusler alloys with minimal amounts of detrimental phases. In the alloy design step, Ti, Zr, and Hf were typically mixed at the M sites to reduce lattice thermal conductivity. To address cost and production efficiency concerns associated with incorporating Hf, alloy compositions with reduced Hf content were designed. A comparative analysis of the thermoelectric properties of Ti0.5Zr0.17Hf0.33NiSn(1-x)Sbx (x = 0.02 similar to 0.08) was conducted by varying doping levels of Sb as the dopant element. The addition of Sb led to a gradual increase in electron concentration, resulting in a significant rise in electrical conductivity. However, this increase in electronic thermal conductivity had a detrimental effect on the overall dimensionless Fig. of merit ZT value. The maximum ZT value of 0.92 was achieved in Ti0.5Zr0.17Hf0.33NiSn0.98Sb0.02 at 773K, demonstrating the potential of Hf-reduced half-Heusler alloys synthesized by RSP for thermoelectric applications. | Park, Eunjin; Yi, Seong-Hoon | Kyungpook Natl Univ, Sch Mat Sci & Engn, Dept Mat Sci & Met Engn, Daegu 41566, South Korea | 59728627500; 14008383000 | yish@knu.ac.kr; | KOREAN JOURNAL OF METALS AND MATERIALS | KOREAN J MET MATER | 1738-8228 | 63 | 4 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2024 | 1.4 | 58.9 | 0 | 2025-05-07 | 0 | 0 | Half-Heusler phase; Thermoelectric material; Rapid solidification | TRANSPORT-PROPERTIES; TINISN; PERFORMANCE; SEMICONDUCTOR; ZRNISN; METAL | Half-Heusler phase; Rapid solidification; Thermoelectric material | Antimony alloys; Antimony compounds; Germanium compounds; Hafnium; Hafnium compounds; Manganese alloys; Mercury amalgams; Metal casting; Metal castings; Rapid solidification; Rapid thermal processing; Titanium alloys; Titanium compounds; Zinc alloys; Zirconium; Zirconium alloys; Zirconium compounds; Half-heusler; Half-Heusler alloys; Half-heusler phase; Heusler phasis; Rapid solidification processing; Sb doping; Thermo-Electric materials; Thermoelectric material; Thermoelectric performance; Thermoelectric properties; Hafnium alloys | Korean | 2025 | 2025-04 | 10.3365/kjmm.2025.63.4.243 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Reduction Behavior of Black Mass Recovered from NCM-Based Spent Lithium-ion Batteries in Ar Atmosphere | With the growing demand for LIBs (lithium-ion batteries) for EVs (electric-powered vehicles), it will be important to recover valuable metals from spent lithium-ion batteries in the future. The black mass recovered from spent lithium-ion battery contains elements such as Li, Ni, Co, and Mn with C. The carbon in the black mass can act as a reducing agent of oxide. This study investigated the effect of reaction temperature on the reduction behavior and Li recovery from black mass powder mixed with spent NCM (LiNiXCoYMnZO2) powder and C in an Ar atmosphere. In the isothermal reaction, the weight loss rate increased with an increase of temperature, and the final amount of weight loss also increased. After significant weight loss, the NCM powder was decomposed and nickel and cobalt oxides were reduced to metals. When significant weight loss occurred, a significant amount of CO gas was also emitted. This phenomenon is due to the reduction of nickel and cobalt oxides in the black mass and the reaction of CO2 with C by the Boudouard reaction. When the isothermally reacted black mass was leached in water, the Li recovery increased with an increase of the reaction temperature, and the Li recovery above 900 degrees C was about 98%. From these results, by heating the black mass in an inert atmosphere lithium can be separated and recovered from valuable metals and C. | Hwang, Jae-Ho; Lee, Sang-Yeop; Lee, So-Yeong; Sohn, Ho-Sang | Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Mat Sci & Met Engn, Daegu 41566, South Korea | 59943911000; 59943726000; 57208210267; 7201426373 | sohn@knu.ac.kr; | KOREAN JOURNAL OF METALS AND MATERIALS | KOREAN J MET MATER | 1738-8228 | 63 | 6 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2024 | 1.4 | 58.9 | N/A | 0 | 0 | Lithium-ion battery; Reduction; Boudouard reaction; Recycling; Water leaching | Boudouard reaction; Lithium-ion battery; Recycling; Reduction; Water leaching | Cobalt compounds; Cobalt deposits; Ions; Isotherms; Leaching; Lithium compounds; Manganese compounds; Metal recovery; Nickel oxide; Powder metals; Reduction; % reductions; Boudouard reaction; Ion batteries; Lithium ions; Reaction temperature; Reduction behavior; Spent lithium-ion batteries; Valuable metals; Water leaching; Weight loss; Lithium-ion batteries; Recycling | English | 2025 | 2025-06 | 10.3365/kjmm.2025.63.6.430 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Chemical constituents of Himantormia lugubris collected from Antarctica and their PTP1B and α-glucosidase inhibitory activities | A phytochemical investigation of an Antarctic endemic species [Himantormia lugubris (Hue) M. Lamb] led to the isolation and structural elucidation of three new compounds including one lanostane-type triterpenoid (1, himanlugubrol A), one ergostane-type sterol (2, himanlugubrol B), one benzyl orsellinate derivative (3, himanlugubrin A), along with ten known compounds (4-13). The chemical structures of new compounds were determined using diverse NMR techniques, HRESIMS data analysis, and computational approaches supported by advanced statistics (DP4+). The anti-diabetic potential of all isolated compounds was investigated by evaluating their inhibitory effects on PTP1B and alpha-glucosidase enzymes. As a result, compound 3 moderately inhibited PTP1B with an IC50 value of 43.86 mu M and significantly inhibited alpha-glucosidase (IC50 = 73.46 mu M) in comparison to the positive controls, ursolic acid (IC50 = 5.92 mu M) and acarbose (IC50 = 210.11 mu M), respectively. Enzyme kinetic analysis revealed that compound 3 demonstrated noncompetitive inhibition of PTP1B and mixed-type inhibition of alpha-glucosidase. Additionally, molecular docking results supported these in vitro findings, showing that compound 3 had strong binding affinities for the active sites of both PTP1B and alpha-glucosidase, indicated by the key H-bond and van der Waals interactions and negative binding energies. | Ha, Manh Tuan; Le, Thi Thanh; Lee, Da Yeong; Kim, Chung Sub; Youn, Ui Joung; Kim, Sang Hee; Kim, Jeong Ah; Min, Byung Sun | Daegu Catholic Univ, Coll Pharm, Drug Res & Dev Ctr, Gyongsan 38430, Gyeongbuk, South Korea; Sungkyunkwan Univ, Sch Pharm, Suwon 16419, South Korea; Sungkyunkwan Univ, Dept Biopharmaceut Convergence, Suwon 16419, South Korea; Korea Polar Res Inst, Div Life Sci, Incheon 21990, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu 41566, South Korea | Tuan, Ha/AAW-5444-2021; Kim, Chung Sub/GLN-7192-2022 | 57189040434; 57350699400; 57927408300; 12142324700; 16417618600; 57208574704; 24722570900; 55663638200 | sangheekim@kopri.re.kr; jkim6923@knu.ac.kr; bsmin@cu.ac.kr; | PHYTOCHEMISTRY LETTERS | PHYTOCHEM LETT | 1874-3900 | 1876-7486 | 66 | SCIE | CHEMISTRY, MEDICINAL;PLANT SCIENCES | 2024 | 1.4 | 59.2 | 0 | 2025-05-07 | 0 | 0 | Himantormia lugubris; Parmeliaceae; Lanostane-type triterpenoid; Ergostane-type sterol; PTP1B, alpha-glucosidase | TRITERPENOIDS | Ergostane-type sterol; Himantormia lugubris; Lanostane-type triterpenoid; Parmeliaceae; PTP1B, α-glucosidase | 24 methyl 5alpha cholest 22 ene 3beta,5,6beta triol; 3beta,5alpha dihydroxyergost 22 en 6 one; acarbose; alpha glucosidase; antidiabetic agent; atranol; benzyl derivative; brassicasterol; demethylated nidulol; ergosterol; ergosterol peroxide; himanlugubrin a; himanlugubrol a; himanlugubrol b; methyl orsellinate; protein tyrosine phosphatase 1B; sterol derivative; triterpenoid; unclassified drug; ursolic acid; usnic acid; allosteric site; Antarctica; antidiabetic activity; Article; carbon nuclear magnetic resonance; chemical structure; controlled study; drug isolation; drug structure; enzyme inhibition; enzyme kinetic assay; heteronuclear multiple bond correlation; Himantormia lugubris; IC50; lichen (organism); molecular docking; nonhuman; proton nuclear magnetic resonance | English | 2025 | 2025-04 | 10.1016/j.phytol.2025.02.009 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Comparative Chloroplast Genomics and Phylogeny of Crinum brachynema (Amaryllidaceae): A Narrow Endemic Geophyte of the Western Ghats of India | Crinum brachynema (Amaryllidaceae) is an endemic species of the Western Ghats, India. It has high medicinal value and contains galanthamine (GAL) alkaloid, an anti-Alzheimer drug. The development of molecular markers with high-discrimination ability for C. brachynema is important to make species recognition easier and understand phylogeny and therapeutic values. In this study, we successfully assembled and characterized the complete chloroplast (cp.) genome of C. brachynema, revealing a genome of 158,570 base pairs with a typical tetrad structure. The genome contains 113 unique genes, including 79 protein-coding genes (CDS), 30 tRNA genes, and 4 rRNA genes. There were 47 long repeats and 74 simple sequence repeats (SSRs) in the cp. genome that were mostly located in intergenic spacer (IGS). Multiple genome alignments demonstrated a high degree of genomic similarity among seven Amaryllidaceae species with the large single copy (LSC) region exhibiting the most variability. The study identified common hotspot regions, such as rps16-trnQ-UUG, ndhF, rpl32-trnL-UAG, and ycf1 that are shared among Amaryllidaceae species. Phylogenetic analysis revealed a close relationship between C. brachynema and C. asiaticum var. pedunculatum. The outcomes of this study can be applied to epidemiological genetics research enhancing our understanding of cp. genomics. Additionally, this study would serve as a valuable resource for species identification, molecular breeding, and evaluating interspecific diversity within the Crinum genus. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025. | Tamboli, Asif S.; Shelke, Priya E.; Chougule, Rupali N.; Youn, Jin-Suk; Choo, Yeon-Sik; Pak, Jae Hong; Lekhak, Manoj M. | Research Institute for Dok-Do and Ulleung-Do Island, Kyungpook National University, 80 Daehak-Ro, Buk-Gu, Daegu, 41566, South Korea; Angiosperm Taxonomy Laboratory, Department of Botany, Shivaji University, Maharashtra, Kolhapur, India; Angiosperm Taxonomy Laboratory, Department of Botany, Shivaji University, Maharashtra, Kolhapur, India; Research Institute for Dok-Do and Ulleung-Do Island, Kyungpook National University, 80 Daehak-Ro, Buk-Gu, Daegu, 41566, South Korea; Research Institute for Dok-Do and Ulleung-Do Island, Kyungpook National University, 80 Daehak-Ro, Buk-Gu, Daegu, 41566, South Korea, Department of Biology, School of Life Sciences, Kyungpook National University, 80 Daehak-Ro, Buk-Gu, Daegu, 41566, South Korea; Research Institute for Dok-Do and Ulleung-Do Island, Kyungpook National University, 80 Daehak-Ro, Buk-Gu, Daegu, 41566, South Korea; Angiosperm Taxonomy Laboratory, Department of Botany, Shivaji University, Maharashtra, Kolhapur, India | 56974034100; 57966621800; 57439752000; 57210840807; 26040458100; 7102232932; 35573958700 | jhpak@knu.ac.kr; botany@unishivaji.ac.in; | Plant Molecular Biology Reporter | PLANT MOL BIOL REP | 0735-9640 | 1572-9818 | SCIE | BIOCHEMICAL RESEARCH METHODS;PLANT SCIENCES | 2024 | 1.4 | 59.2 | 0 | 2025-05-07 | 0 | Alzheimer’s disease; Chloroplast genome; Crinum; Endemic species; Phylogeny | English | Article in press | 2025 | 10.1007/s11105-025-01536-y | 바로가기 | 바로가기 | 바로가기 |
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