연구성과로 돌아가기
2022 연구성과 (122 / 280)
※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ○ | ○ | Article | Kinetics of neutralizing antibodies against SARS-CoV-2 infection according to sex, age, and disease severity | Knowledge of the factors affecting the difference in kinetics and longevity of the neutralizing antibody (nAb) response to SARS-CoV-2 is necessary to properly prioritize vaccination. In the present study, from March to December 2020, of the 143 patients who recovered from COVID-19, 87 underwent study visits scheduled every 3 months. Patient demographics and blood samples were collected followed by a plaque reduction neutralization test to analyze nAb titers. A linear mixed model was used to compare the effects of sex, age, and disease severity over time. Results demonstrated a gradual reduction in nAb titers over time with a significant decrease from 6 to 9 months post-COVID-19 infection (p = 50 years than in those aged < 50 years (p = 0.036) irrespective of time Moreover, the nAb titer was 2.41 times higher in the moderate or above than that in the below moderate disease severity group (p < 0.001). However, no significant differences were observed in terms of sex (p = 0.300). Given the reduction in nAbs over time, maintaining protective neutralizing antibodies regardless of sex, age, or disease severity is needed. | Kim, Yoonjung; Bae, Joon-Yong; Kwon, Kitae; Chang, Hyun-Ha; Lee, Won Kee; Park, Heedo; Kim, Jeonghun; Choi, Isaac; Park, Man-Seong; Kim, Shin-Woo | Kyungpook Natl Univ, Sch Med, Kyungpook Natl Univ Hosp, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Korea Univ, Coll Med, Biosafety Ctr, Dept Microbiol,Inst Viral Dis, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Med Informat, Daegu, South Korea | Kim, Ji Hoon/AAB-4602-2022; Park, Man-Seong/AAF-1207-2020; Kim, Sun/G-3451-2013; Kim, Jeong/J-2748-2012; Kim, Hanjin/KYP-2633-2024 | 57203160508; 55201437800; 9733850500; 7407521688; 22953484700; 57222394276; 57221379773; 57835389400; 7404491121; 57189703358 | ms0392@korea.ac.kr;ksw2kms@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.5 | 2025-06-25 | 6 | 7 | RATES | Antibodies, Neutralizing; Antibodies, Viral; COVID-19; Humans; SARS-CoV-2; Severity of Illness Index; neutralizing antibody; virus antibody; human; severity of illness index | English | 2022 | 2022-08-05 | 10.1038/s41598-022-17605-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Larvicidal Activity of Methyl Benzoate, a Volatile Organic Compound, Against the Mosquitoes Aedes albopictus and Culex pipiens (Diptera: Culicidae) | Methyl benzoate (MBe) is a volatile organic molecule found in various plants; it is used as an insect semiochemical. MBe also has a biorational insecticidal effect against various agricultural and urban arthropod pests. The present study was the first to assess the larvicidal potential of MBe against fourth-instar larvae of the mosquitoes Aedes albopictus (Skuse) and Culex pipiens (L.). A positive association was observed between MBe concentrations and larval mortality in both the species. The highest mortality recorded was 100% for Ae. albopictus and 56% for Cx. pipiens after 24 h of exposure to 200 ppm MBe. The lethal median concentration (LC50) values of MBe against fourth-instar larvae of Ae. albopictus and Cx. pipiens were 61 ppm and 185 ppm, respectively. These results suggest that MBe has great potential for use as an environmentally friendly larvicidal agent for mosquito control. | Mostafiz, Md Munir; Ryu, Jihun; Akintola, Ashraf Akintayo; Choi, Kwang Shik; Hwang, Ui Wook; Hassan, Errol; Lee, Kyeong-Yeoll | Kyungpook Natl Univ, Coll Agr & Life Sci, Div Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Biomed Convergence Sci & Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Dok & Ulleung Do Isl, Daegu 41566, South Korea; Univ Queensland Gatton, Sch Agr & Food Sci, Gatton, Qld 4343, Australia | ; Ryu, Jihun/MSY-6008-2025; Mostafiz, Md. Munir/AAD-7664-2019; Akintola, Ashraf/KZU-7081-2024 | 57204895546; 57210884178; 57218618629; 36602283400; 35074015800; 16458195700; 57217153096 | leeky@knu.ac.kr; | JOURNAL OF MEDICAL ENTOMOLOGY | J MED ENTOMOL | 0022-2585 | 1938-2928 | 59 | 2 | SCIE | ENTOMOLOGY;VETERINARY SCIENCES | 2022 | 2.1 | 29.5 | 0.8 | 2025-06-25 | 5 | 5 | climate change; biorational insecticidal effect; mosquito control; plant essential oil; environmentally friendly larvicide | ESSENTIAL OILS; AEGYPTI; CHIKUNGUNYA; MANAGEMENT; TOXICITY; SUSCEPTIBILITY; CHALLENGES; EXTRACTS; VECTORS; DISEASE | biorational insecticidal effect; climate change; environmentally friendly larvicide; mosquito control; plant essential oil | Aedes; Animals; Benzoates; Culex; Insecticides; Larva; Oils, Volatile; Volatile Organic Compounds; benzoic acid; essential oil; insecticide; methyl benzoate; volatile organic compound; Aedes; animal; chemistry; Culex; larva | English | 2022 | 2022-03-16 | 10.1093/jme/tjab230 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Midtrimester cervical elastography in pregnant women with a history of loop electrosurgical excision procedure (LEEP) | We aimed to compare cervical elastographic parameters based on a previous loop electrosurgical excision procedure (LEEP) and to determine whether they can predict preterm delivery in pregnant women with a history of LEEP. This multicenter prospective case-control study included 71 singleton pregnant women at 14-24 weeks of gestation with a history of LEEP and 1:2 gestational age-matched controls. We performed cervical elastography using E-cervix and compared maternal characteristics, delivery outcomes, cervical length (CL), and elastographic parameters between the two groups. The median mid-trimester CL was significantly shorter in the LEEP group. Most elastographic parameters, including internal os (IOS), external os (EOS), elasticity contrast index (ECI), and hardness ratio (HR), were significantly different in the two groups. In the LEEP group, the sPTD group compared to the term delivery (TD) group showed a higher rate of previous sPTD (50% vs. 1.7%, p < 0.001), higher IOS and ECI (IOS: 0.28 [0.12-0.37] vs. 0.19 [0.10-0.37], p = 0.029; ECI: 3.89 [1.79-4.86] vs. 2.73 [1.48-5.43], p = 0.019), and lower HR (59.97 [43.88-92.43] vs. 79.06 [36.87-95.40], p = 0.028), but there was no significant difference in CL (2.92 [2.16-3.76] vs. 3.13 [1.50-3.16], p = 0.247). In conclusion, we demonstrated that a history of LEEP was associated with a change in cervical strain measured in mid-trimester as well as with CL shortening. We also showed that cervical elastography can be useful in predicting sPTD in pregnant women with previous LEEP. | Cha, Hyun-Hwa; Seong, Won Joon; Kim, Hyun Mi; Seol, Hyun-Joo; Sung, Ji-Hee; Park, Hyun Soo; Hwang, Han-Sung; Kwon, Hayan; Jung, Yun Ji; Kwon, Ja-Young; Oh, Soo-young | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Obstet & Gynecol, Daegu, South Korea; Kyung Hee Univ, Sch Med, Dept Obstet & Gynecol, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Obstet & Gynecol, 81 Irwon Ro, Seoul 06351, South Korea; Dongguk Univ, Grad Sch Med, Dept Obstet & Gynecol, Goyang, South Korea; Konkuk Univ, Med Ctr, Sch Med, Dept Obstet & Gynecol, Seoul, South Korea; Yonsei Univ, Coll Med, Inst Womens Life Med Sci, Dept Obstet & Gynecol, Seoul, South Korea | 37033517800; 26656946000; 57219838830; 15924081200; 56347330000; 59442050000; 17345595900; 36865684900; 56581000200; 8656241100; 55601514300 | ohsymd@skku.edu; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.28 | 2025-06-25 | 5 | 4 | PRIOR CONE BIOPSY; PRETERM BIRTH; LENGTH; DELIVERY; ULTRASONOGRAPHY; PREDICTION; RISK | Case-Control Studies; Cervix Uteri; Elasticity Imaging Techniques; Electrosurgery; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Trimester, Second; Pregnant Women; case control study; clinical trial; diagnostic imaging; elastography; electrosurgery; female; human; multicenter study; newborn; pregnancy; pregnant woman; second trimester pregnancy; surgery; uterine cervix | English | 2022 | 2022-06-02 | 10.1038/s41598-022-13170-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Modeling Incorporating the Severity-Reducing Long-term Immunity: Higher Viral Transmission Paradoxically Reduces Severe COVID-19 During Endemic Transition | Natural infection with severe acute respiratory syndrome-coronavirus-2 or vaccination induces virus-specific immunity protecting hosts from infection and severe disease. While the infection-preventing immunity gradually declines, the severity-reducing immunity is relatively well preserved. Here, based on the different longevity of these distinct immunities, we develop a mathematical model to estimate courses of endemic transition of coronavirus disease 2019 (COVID-19). Our analysis demonstrates that high viral transmission unexpectedly reduces the rates of progression to severe COVID-19 during the course of endemic transition despite increased numbers of infection cases. Our study also shows that high viral transmission amongst populations with high vaccination coverages paradoxically accelerates the endemic transition of COVID-19 with reduced numbers of severe cases. These results provide critical insights for driving public health policies in the era of 'living with COVID-19.' | Hong, Hyukpyo; Noh, Ji Yun; Lee, Hyojung; Choi, Sunhwa; Choi, Boseung; Kim, Jae Kyoung; Shin, Eui-Cheol | Korea Adv Inst Sci & Technol KAIST, Dept Math Sci, Daejeon 34141, South Korea; Biomed Math Grp, Inst Basic Sci IBS, Daejeon 34126, South Korea; Korea Adv Inst Sci & Technol KAIST, Grad Sch Med Sci & Engn, Lab Immunol & Infect Dis, Daejeon 34141, South Korea; Korea Univ, Div Infect Dis, Dept Internal Med, Coll Med, Seoul 02841, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu 41566, South Korea; Natl Inst Math Sci, Div Fundamental Res Publ Agenda, Daejeon 34047, South Korea; Korea Univ, Div Big Data Sci, Sejong 30019, South Korea; Korea Virus Res Inst, Inst Basic Sci IBS, Ctr Viral Immunol, Daejeon 34126, South Korea | ; Choi, Sunhwa/D-8320-2011; Hong, Hyukpyo/JWO-7035-2024; Kim, Jae Kyoung/F-1297-2015; Shin, Eui-Cheol/C-1690-2011 | 57223215809; 24587375200; 57196021198; 49961295500; 25026927400; 56150933800; 7202356401 | jaekkim@kaist.ac.kr;ecshin@kaist.ac.kr; | IMMUNE NETWORK | IMMUNE NETW | 1598-2629 | 2092-6685 | 22 | 3 | SCIE | IMMUNOLOGY | 2022 | 6 | 29.5 | 0.19 | 2025-06-25 | 2 | 2 | COVID-19; SARS-CoV-2; Immunity; Severity; Endemic transition | SARS-COV-2; VACCINE | COVID-19; Endemic transition; Immunity; SARS-CoV-2; Severity | anti-SARS-CoV-2 agent; molnupiravir; SARS-CoV-2 vaccine; Article; basic reproduction number; breakthrough infection; compartment model; coronavirus disease 2019; disease burden; disease course; disease severity; endemic disease; health care policy; hospitalization; human; longevity; mathematical model; public health; secondary infection; vaccination; vaccination coverage; virus immunity; virus transmission | English | 2022 | 2022-06 | 10.4110/in.2022.22.e23 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Non-Helicobacter pylori Helicobacter (NHPH) positive gastric cancer | Genetic analysis and culturing techniques for gastric non-Helicobacter pylori Helicobacter (NHPH) are progressing. NHPH is reported to accompany nodular gastritis, gastric MALT lymphoma, and mild gastritis. However, only a few gastric cancer cases infected by NHPH have been reported. PCR analysis specific for NHPH and H. pylori was performed for DNA from gastric mucosa of 282 Korean gastric cancer patients, who were treated with endoscopic submucosal dissection. For more precise strain detection of NHPH, NHPH-positive mucosa was stained by immunohistochemistry specific for Helicobacter suis. The Cancer Genome Atlas (TCGA) classification was analyzed for these 3 gastric cancer sub-groups by in situ hybridization and immunohistochemistry. Among 281 patients, 3 patients (1.1%) were positive for NHPH. One patient (Patient 1) was also positive for H. pylori by PCR, another patient (Patient 3) was positive for serum IgG for H. pylori, and the other patient (Patient 2) had no evidence for H. pylori infection. Gastric mucosa of Patients 2 and 3 were positive for H. suis staining. All three NHPH-positive gastric cancers were located in the antrum, and belonged to the Chromosomal Instability Type of TCGA classification. Gastric NHPH can be a cause of gastric cancer, although likely with lower pathogenesis than H. pylori. | Yasuda, Tomohiko; Lee, Hyun Seok; Nam, Su Youn; Katoh, Hiroto; Ishibashi, Yuko; Murayama, Somay Yamagata; Matsui, Hidenori; Masuda, Hiroki; Rimbara, Emiko; Sakurazawa, Nobuyuki; Suzuki, Hideyuki; Yoshida, Hiroshi; Seto, Yasuyuki; Ishikawa, Shumpei; Jeon, Seong Woo; Nakamura, Masahiko; Nomura, Sachiyo | Univ Tokyo, Grad Sch Med, Dept Gastrointestinal Surg, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan; Nippon Med Sch, Chiba Hokusoh Hosp, Dept Gastrointestinal Surg, Chiba, Japan; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Univ Tokyo, Grad Sch Med, Dept Prevent Med, Tokyo, Japan; Univ Tokyo, Grad Sch Med, Dept Breast & Endocrine Surg, Tokyo, Japan; Natl Inst Infect Dis, Dept Chemotherapy & Mycoses, Tokyo, Japan; Kitasato Univ, Omura Satoshi Mem Inst, Tokyo, Japan; Nippon Med Sch, Dept Gastrointestinal & Hepatobiliary Pancreat Su, Tokyo, Japan; Natl Inst Infect Dis, Dept Bacteriol 2, Tokyo, Japan | Nakamura, Masahiko/KEI-0244-2024; Jeon, Seongwoo/AAU-4618-2020; Ishikawa, Shumpei/NBW-9562-2025; Katoh, Hiroto/ADO-8117-2022; Rimbara, Emiko/F-4113-2017 | 57196322671; 36647886100; 55617028500; 59096586700; 57194762025; 56857509900; 57200956968; 57222521673; 8660827400; 6505785530; 57216605723; 57205371689; 7102216638; 57872141000; 9733636500; 7405341212; 35427653500 | sachiyo.nomura1012@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 1.14 | 2025-06-25 | 16 | 16 | HEILMANNII INFECTION; PREVALENCE; ORGANISMS; PATIENT | Gastric Mucosa; Gastritis; Helicobacter; Helicobacter Infections; Helicobacter pylori; Humans; Stomach Neoplasms; gastritis; genetics; Helicobacter; Helicobacter infection; Helicobacter pylori; human; pathology; stomach mucosa; stomach tumor | English | 2022 | 2022-03-21 | 10.1038/s41598-022-08962-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Oncologic necessity for the complete removal of residual microcalcifications after neoadjuvant chemotherapy for breast cancer | The surgical range of breast cancer that shows pathologic complete response (pCR) without change in microcalcifications after neoadjuvant chemotherapy (NAC) is controversial. This study examined whole breast specimens to evaluate the necessity of mastectomy in those cases. The viability of cancer cells around the residual microcalcification was assessed using prospectively collected breast samples to confirm the presence or absence of cancer cells. A total of 144 patients with breast cancer and diffuse microcalcifications were classified into the reduced mass with no change in residual microcalcification (RESMIN, n = 49) and non-RESMIN (n = 95) groups. Five specimens were prospectively evaluated to assess the presence of viable cancer cells around the microcalcification. Tumor responses to NAC were significantly better with high pCR rates in the RESMIN group (p = 0.005 and p = 0.002). The incidence of human epidermal growth factor receptor 2-positive and triple-negative breast cancers was significantly high in the RESMIN group (p = 0.007). Although five (10.2%) patients had locoregional recurrence in the RESMIN group, no local recurrence in the breast was reported. Although pCR was highly estimated, residual cancers, including ductal carcinoma in situ, remained in 80% cases. Therefore, given the weak scientific evidence available currently, complete removal of residual microcalcifications should be considered for oncologic safety. | Lee, Jeeyeon; Park, Nora Jee-Young; Park, Ho Yong; Kim, Wan Wook; Kang, Byeongju; Keum, Heejung; Kim, Hye Jung; Kim, Won Hwa; Chae, Yee Soo; Lee, Soo Jung; Lee, In Hee; Park, Ji-Young; Jung, Jin Hyang | Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Hematol Oncol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Daegu, South Korea | Park, Jin-Young/HDN-0483-2022; PARK, JUN-YOUNG/P-5981-2015 | 37079213100; 57226185359; 56564377200; 26023273400; 57279815300; 57221998716; 57203506201; 36081886500; 57190793908; 57203597252; 57191881516; 57210160197; 57209310173 | jyparkmd@knu.ac.kr;jjh01@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.5 | 2025-06-25 | 7 | 7 | PREOPERATIVE CHEMOTHERAPY; LESIONS; CALCIFICATIONS; CARCINOMAS; WOMEN | Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Calcinosis; Chemotherapy, Adjuvant; Female; Humans; Mammography; Mastectomy; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Receptor, ErbB-2; Retrospective Studies; Triple Negative Breast Neoplasms; antineoplastic agent; epidermal growth factor receptor 2; adjuvant chemotherapy; breast tumor; calcinosis; drug therapy; female; human; mammography; mastectomy; metabolism; neoadjuvant therapy; pathology; retrospective study; triple negative breast cancer; tumor recurrence | English | 2022 | 2022-12-13 | 10.1038/s41598-022-24757-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Phylogenomic insight into dysploidy, speciation, and plastome evolution of a small Mediterranean genus Reichardia (Cichorieae; Asteraceae) | Reichardia Roth is a small Mediterranean genus comprising ten homogeneous species with basic chromosome numbers of 7, 8, and 9. To assess the plastid genome evolution and differentiation of Reichardia species, we assembled the complete plastome sequences of seven Reichardia and two Launaea species and conducted various phylogenomic analyses comparatively with nuclear ribosomal DNA ITS sequences. Reichardia and Launaea plastomes were highly conserved in gene content and order, containing 130 genes. Plastid phylogenomic reconstruction strongly suggested that Reichardia was a sister to Launaea, and its common ancestor initially diverged into two major lineages: the first containing species with n = 8 chromosomes exclusively, and the other with n = 9, 8, and 7 chromosomes. Although the ancestral Reichardia karyotype was suggested to most likely be n =9 from ancestral chromosome number reconstruction, the pattern of descending dysploidy indicated by the phylogenetic trees based on nuclear ribosomal DNA ITS was less evident in the trees based on the plastome. Possible reasons for these findings are discussed. | Cho, Myong-Suk; Yang, JiYoung; Mejias, Jose A.; Kim, Seung-Chul | Sungkyunkwan Univ, Dept Biol Sci, Suwon 16419, South Korea; Kyungpook Natl Univ, Res Inst Dok Do & Ulleung Do Isl, Daegu 41566, South Korea; Univ Seville, Dept Plant Biol & Ecol, Seville, Spain | Kim, Seung-Chul/AAR-6157-2020; Mejias, Jose/AAC-5599-2020 | 56326352700; 55193226000; 57241563300; 57214983739 | sonchus96@skku.edu; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.21 | 2025-06-25 | 3 | 3 | SUBTRIBE SONCHINAE ASTERACEAE; ADAPTIVE RADIATION; CHLOROPLAST DNA; COLONIZATION; SELECTION; SOFTWARE; SONCHUS; LACTUCEAE; INFERENCE; ALIGNMENT | Asteraceae; DNA, Ribosomal; Evolution, Molecular; Genome, Plastid; Phylogeny; Tabernaemontana; ribosome DNA; Asteraceae; genetics; molecular evolution; phylogeny; plastid genome; Tabernaemontana | English | 2022 | 2022-06-30 | 10.1038/s41598-022-15235-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Physician adherence and patient-reported outcomes in heart failure with reduced ejection fraction in the era of angiotensin receptor-neprilysin inhibitor therapy | This Korean nationwide, multicenter, noninterventional, prospective cohort study aimed to analyze physician adherence to guideline-recommended therapy for heart failure (HF) with reduced ejection fraction (HFrEF) and its effect on patient-reported outcomes (PROs). Patients diagnosed with or hospitalized for HFrEF within the previous year were enrolled. Treatment adherence was considered optimal when all 3 categories of guideline-recommended medications (angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, or angiotensin receptor-neprilysin inhibitors; beta-blockers; and mineralocorticoid receptor antagonists) were prescribed and suboptimal when <= 2 categories were prescribed. The 36-Item Short Form Survey (SF-36) scores were compared at baseline and 6 months between the 2 groups. Overall, 854 patients from 30 hospitals were included. At baseline, the optimal adherence group comprised 527 patients (61.7%), whereas during follow-up, the optimal and suboptimal adherence groups comprised 462 (54.1%) and 281 (32.9%) patients, respectively. Patients in the suboptimal adherence group were older, with a lower body mass index, and increased comorbidities, including renal dysfunction. SF-36 scores were significantly higher in the optimal adherence group for most domains (P < 0.05). This study showed satisfactory physician adherence to contemporary treatment for HFrEF. Optimal adherence to HF medication significantly correlated with better PROs. | Kim, In-Cheol; Youn, Jong-Chan; Jang, Se Yong; Lee, Sang Eun; Cho, Hyun-Jai; Choi, Jin-Oh; Lee, Ju-Hee; Kim, Kyung-Hee; Lee, Sun Hwa; Kim, Kye Hun; Lee, Jong Min; Yoo, Byung-Su | Keimyung Univ, Coll Med, Dept Internal Med, Div Cardiol,Dongsan Hosp, Daegu, South Korea; Catholic Univ Korea, Coll Med, Catholic Res Inst Intractable Cardiovasc Dis, Div Cardiol,Dept Internal Med,Seoul St Marys Hosp, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Div Cardiol, Daegu, South Korea; Asan Med Ctr, Dept Internal Med, Div Cardiol, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Div Cardiol, Seoul, South Korea; Samsung Med Ctr, Dept Internal Med, Div Cardiol, Seoul, South Korea; Incheon Sejong Hosp, Dept Internal Med, Div Cardiol, Incheon, South Korea; Jeonbuk Natl Univ Hosp, Dept Internal Med, Div Cardiol, Jeonju, South Korea; Chonnam Natl Univ Hosp, Coll Med, Dept Internal Med, Div Cardiol, Gwangju, South Korea; Catholic Univ Korea, Coll Med, Uijeongbu St Marys Hosp, Div Cardiol,Dept Internal Med, Uijongbu, South Korea; Yonsei Univ, Wonju Coll Med, Div Cardiol, Dept Internal Med,Wonju Severance Christian Hosp, 20 Ilsan Ro, Wonju 26426, Gangwon Do, South Korea | Kim, Hyun-Chang/G-6624-2015; lee, sun hwa/R-1431-2019; Choi, Joon/D-6140-2017; Lee, Jong Min/HJY-8328-2023; LEE, JI/L-6920-2013; Youn, Jong-Chan/AAS-1405-2020; Kim, Kyung-Hee/JBI-8300-2023 | 55477715300; 14070921900; 57207977889; 57207065107; 35285421400; 15848011800; 57204073070; 57209988283; 57887827800; 56150430800; 56765392700; 7102851884; 56399550000; 58392341700; 59858642600; 58847286300; 57201935119; 36007319200; 36063048400; 57190673137; 7404507139; 7005028587; 57212676463; 36723733700; 56124196600; 56053351800; 35740671300; 57225790014; 56669926200 | yubs@yonsei.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.43 | 2025-06-25 | 5 | 6 | QUALITY-OF-LIFE; PERFORMANCE-MEASURES; ELDERLY-PATIENTS; MANAGEMENT; GUIDELINE | Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Antihypertensive Agents; Guideline Adherence; Heart Failure; Humans; Mineralocorticoid Receptor Antagonists; Neprilysin; Patient Reported Outcome Measures; Physicians; Prospective Studies; Receptors, Angiotensin; Registries; Stroke Volume; angiotensin receptor; angiotensin receptor antagonist; antihypertensive agent; beta adrenergic receptor blocking agent; membrane metalloendopeptidase; mineralocorticoid antagonist; clinical trial; heart failure; heart stroke volume; human; multicenter study; patient-reported outcome; physician; physiology; prospective study; protocol compliance; register | English | 2022 | 2022-05-11 | 10.1038/s41598-022-11740-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Prediction of maternal complications and neonatal outcome in dichorionic diamniotic twins with fetal weight discordancy measured by ultrasonography | This study aimed to determine the relationship between estimated fetal weight discordance by ultrasonography and maternal and neonatal outcomes in dichorionic diamniotic twin pregnancies. We conducted a retrospective review of the medical records of 106 twin pregnancies delivered at a single tertiary center between January 2011 and February 2020. At 20-24 and 28-32 weeks of gestation, participants were divided into two groups: discordant twins with an estimated fetal weight difference of more than 20% and concordant twins with a weight difference of less than 20%. Maternal complications and neonatal outcomes were compared between the two groups. Although the incidences of preeclampsia and placenta previa were significantly higher in discordant twins measured between 20 and 24 weeks, no statistical significance was found in neonatal outcomes. Delivery times were earlier, and neonatal weights were lower in discordant twins measured between 28 and 32 weeks. Neonatal outcomes such as ventilator use and neurodevelopment were also significantly different. Discordance in estimated fetal weight measured using ultrasonography between 20 and 24 weeks can be a risk factor for maternal preeclampsia and placenta previa, whereas discordance at 28-32 weeks may predict poor neonatal outcomes. | Kim, Hyun Mi; Cha, Hyun-Hwa; Seong, Won Joon; Lee, Hye Jin; Kim, Mi Ju | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Obstet & Gynecol, Daegu 41944, South Korea | LEE, HYEJIN/W-1345-2018; Kim, Mi Ju/HGU-8470-2022 | 57219838830; 37033517800; 26656946000; 57869430500; 55908927600 | ties1004@naver.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.21 | 2025-06-25 | 6 | 3 | GROWTH; MORBIDITY; DIAGNOSIS; MORTALITY; AGE | English | 2022 | 2022-09-01 | 10.1038/s41598-022-18864-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Prognostic value of the metabolic score obtained via [¹⁸F]FDG PET/CT and a new prognostic staging system for gastric cancer | We developed and validated a new staging system that includes metabolic information from pretreatment [F-18]Fluorodeoxyglucose ([F-18]FDG) positron emission tomography/computed tomography (PET/CT) for predicting disease-specific survival (DSS) in gastric cancer (GC) patients. Overall, 731 GC patients undergoing preoperative [F-18]FDG PET/CT were enrolled and divided into the training (n=543) and validation (n=188) cohorts. A metabolic score (MS) was developed by combining the maximum standardized uptake value (SUVmax) of the primary tumor (T_SUVmax) and metastatic lymph node (N_SUVmax). A new staging system incorporating the MS and tumor-node-metastasis (TNM) stage was developed using conditional inference tree analysis. The MS was stratified as follows: score 1 (T_SUVmax 4.5 and N_SUVmax 1.9), and score 4 (T_SUVmax>4.5 and N_SUVmax>1.9) in the training cohort. The new staging system yielded five risk categories: category I (TNM I, II and MS 1), category II (TNM I, II and MS 2), category III (TNM I, II and MS >= 3), category IV (TNM III, IV and MS <= 3), and category V (TNM III, IV and MS 4) in the training cohort. DSS differed significantly between both staging systems; the new staging system showed better prognostic performance in both training and validation cohorts. The MS was an independent prognostic factor for DSS, and discriminatory power of the new staging system for DSS was better than that of the conventional TNM staging system alone. | Kim, Sung Hoon; Song, Bong-Il; Kim, Hae Won; Won, Kyoung Sook; Son, Young-Gil; Ryu, Seung Wan; Kang, Yoo Na | Keimyung Univ, Dept Nucl Med, Sch Med, Daegu, South Korea; Yeungnam Univ Hosp, Dept Nucl Med, Daegu, South Korea; Keimyung Univ, Dept Nucl Med, Dongsan Hosp, Daegu, South Korea; Keimyung Univ, Sch Med, Dept Surg, Dongsan Hosp, Daegu, South Korea; Kyungpook Natl Univ, Dept Forens Med, Sch Med, Daegu, South Korea | ; Song, Bong-il/LIC-9102-2024 | 57208285815; 36164442800; 55739523500; 7005951440; 56706881600; 55420795900; 7402784356 | song@dsmc.or.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.07 | 2025-06-25 | 2 | 1 | POSITRON-EMISSION-TOMOGRAPHY; PREDICTIVE-VALUE; FDG UPTAKE; MODEL; METASTASIS; RECURRENCE; SURVIVAL | Fluorodeoxyglucose F18; Humans; Lymph Nodes; Positron Emission Tomography Computed Tomography; Prognosis; Stomach Neoplasms; fluorodeoxyglucose f 18; diagnostic imaging; human; lymph node; positron emission tomography-computed tomography; prognosis; stomach tumor | English | 2022 | 2022-11-30 | 10.1038/s41598-022-24877-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Programmable and tunable flat-top supercontinuum laser sources via electro-optic intensity and phase modulation scheme | In this study, we presented flat-topped coherent supercontinuum lasers with tunable repetition rates and programmable spectral bandwidths. Supercontinuum sources with ultra-broadband and high-repetition-rate coverage can be achieved by merging nonlinearly broadened electro-optic optical frequency combs with optical line-by-line spectrum shaping. Spectral bandwidth programming is implemented by iterative spectrum shaping and input power control of highly nonlinear stages, whereas repetition rate tuning is performed by modulation speed control in optical frequency combs. Herein, we implemented a programmable and tunable flat-topped supercontinuum with a maximum bandwidth and repetition rate of 55 nm at 10 dB and 50 GHz, respectively. To clarify the coherence of the supercontinuum during tuning and programming, we performed a phase-noise analysis. We proposed a remarkably modified self-heterodyne method to measure the phase noise of each mode precisely by filtering specific supercontinuum taps in a Mach-Zehnder interferometer. With this method, it has been proved that the single-sideband spectra in each mode are almost similar to that of the RF clock, indicating that our programmable and tunable supercontinuum generation process added minimal degradation to the phase noise properties. This study shows possibilities for generating hundreds of programmable and tunable flat-topped optical carriers with robustness and coherence. | Song, Minhyup; Song, Minje; Lim, Seungyoung; Choi, Hyunjong; Lee, Taehyun; Choi, Gyudong; Jung, Youngjin; Ahn, Joon Tae | Elect & Telecommun Res Inst, Photon Wireless Devices Res Div, Daejeon 34129, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea; Korea Univ, Sch Comp & Informat Technol, Seoul 02841, South Korea; Korea Univ, Sch Elect Engn, Seoul 02841, South Korea | 43761532400; 57202726212; 57213792974; 57223016828; 59042718400; 56037178100; 57945647700; 7403019198 | sminhyup@etri.re.kr;mjsong@etri.re.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.71 | 2025-06-25 | 8 | 10 | OPTICAL FREQUENCY COMB; REPETITION-RATE; WAVE-FORM; GENERATION; PULSES; 10-GHZ | English | 2022 | 2022-10-27 | 10.1038/s41598-022-22463-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Quantitative measure of concrete fragment using ANN to consider uncertainties under impact loading | In this study, numerical analysis was performed to predict amount of fragments and travel distance after collision of a concrete median barrier with a truck under impact loading using Smooth Particle Hydrodynamics (SPH). The obtained results of the SPH analysis showed that amount of fragments and the travel distance can be changed depending on different velocity-to-mass ratios under same local impact energy. Using the results of the SPH analysis, artificial neural network (ANN) was constructed to consider the uncertainties for the prediction of amount of fragments and travel distance of concrete after collision. In addition, the results of the ANN were compared with the results of multiple linear regression analysis (MRA). The ANN results showed better coefficient of determination (R-2) than the MRA results. Therefore, the ANN showed improvement than the MRA results in terms of the uncertainties of the prediction of amount of fragments and travel distance. Using the constructed ANN, data augmentation was conducted from a limited number of analysis data using a statistical distribution method. Finally, the fragility curves of the concrete median barrier were suggested to estimate the probability of exceed specific amount of fragments and travel distance under same impact energy. | Kim, Kyeongjin; Kim, WooSeok; Seo, Junwon; Jeong, Yoseok; Lee, Jaeha | Natl Korea Maritime & Ocean Univ, Civil Engn, Busan 49112, South Korea; Natl Korea Maritime & Ocean Univ, Ocean Renewable Energy Engn, Busan 49112, South Korea; Chungnam Natl Univ, Dept Civil Engn, 99 Daehak Ro, Daejeon 34134, South Korea; South Dakota State Univ, Dept Civil & Environm Engn, Brookings, SD 57007 USA; Kyungpook Natl Univ, Dept Construct & Disaster Prevent Engn, 2559 Kyungsangdae Ro, Sangju 37224, South Korea | Seo, Junwon/AAH-8029-2019 | 55976314300; 56286036900; 24469249700; 54980727300; 57014428600 | jaeha@kmou.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.43 | 2025-06-25 | 6 | 6 | RESISTANCE; SIMULATION | article; artificial neural network; hydrodynamics; prediction; probability; quantitative analysis; statistical distribution; travel; uncertainty | English | 2022 | 2022-07-04 | 10.1038/s41598-022-15253-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Relationship between continuity of care and clinical outcomes in patients with dyslipidemia in Korea: a real world claims database study | Dyslipidemia is a risk factor for atherosclerotic cardiovascular disease and requires proactive management. This study aimed to investigate the association between care continuity and the outcomes of patients with dyslipidemia. We conducted a retrospective cohort study on patients with dyslipidemia by employing the Korea National Health Insurance claims database during the period 2007-2018. The Continuity of Care Index (COCI) was used to measure continuity of care. We considered incidence of atherosclerotic cardiovascular disease as a primary outcome. A Cox's proportional hazards regression model was used to quantify risks of primary outcome. There were 236,486 patients newly diagnosed with dyslipidemia in 2008 who were categorized into the high and low COC groups depending on their COCI. The adjusted hazard ratio for the primary outcome was 1.09 times higher (95% confidence interval: 1.06-1.12) in the low COC group than in the high COC group. The study shows that improved continuity of care for newly-diagnosed dyslipidemic patients might reduce the risk of atherosclerotic cardiovascular disease. | Lee, Juhee; Choi, Eunyoung; Choo, Eunjung; Linda, Siachalinga; Jang, Eun Jin; Lee, Iyn-Hyang | Kyungpook Natl Univ, Dept Stat, Daegu 41566, South Korea; Yeungnam Univ, Coll Pharm, Gyongsan 38541, South Korea; Ulsan Univ Hosp, Dept Pharm, Ulsan 44033, South Korea; Ajou Univ, Coll Pharm, Suwon 16499, South Korea; Andong Natl Univ, Dept Informat Stat, Andong 36729, South Korea; Univ York, Dept Hlth Sci, York YO10 5DD, N Yorkshire, England | 57210897006; 57657481400; 57218497400; 57464745400; 37861741600; 54780158300 | ejjang@anu.ac.kr;leeiynhyang@ynu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.5 | 2025-06-25 | 8 | 8 | OBSTRUCTIVE PULMONARY-DISEASE; AVOIDABLE HOSPITALIZATIONS; MANAGEMENT; ASSOCIATION; PREVENTION; GUIDELINES; PROVIDER; CHOICE; IMPACT; COSTS | Adult; Atherosclerosis; Continuity of Patient Care; Databases, Factual; Dyslipidemias; Female; Follow-Up Studies; Humans; Incidence; Insurance Claim Review; Male; Middle Aged; National Health Programs; Office Visits; Patient Acceptance of Health Care; Proportional Hazards Models; Republic of Korea; Retrospective Studies; Risk Factors; Treatment Outcome; adult; ambulatory care; atherosclerosis; dyslipidemia; factual database; female; follow up; human; incidence; insurance; male; middle aged; organization and management; patient attitude; patient care; proportional hazards model; public health; retrospective study; risk factor; South Korea; treatment outcome | English | 2022 | 2022-02-23 | 10.1038/s41598-022-06973-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Sex disparities in mortality among patients with kidney failure receiving dialysis | Females are known to have a better survival rate than males in the general population, but previous studies have shown that this superior survival is diminished in patients on dialysis. This study aimed to investigate the risk of mortality in relation to sex among Korean patients undergoing hemodialysis (HD) or peritoneal dialysis (PD). A total of 4994 patients with kidney failure who were receiving dialysis were included for a prospective nationwide cohort study. Cox multivariate proportional hazard models were used to determine the association between sex and the risk of cause-specific mortality according to dialysis modality. During a median follow-up of 5.8 years, the death rate per 100 person-years was 6.4 and 8.3 in females and males, respectively. The female-to-male mortality rate in patients on dialysis was 0.77, compared to 0.85 in the general population. In adjusted analyses, the risk of all-cause mortality was significantly lower for females than males in the entire population (hazard ratio [HR] 0.79, 95% confidence interval [CI] 0.71-0.87, P < 0.001). No significant differences in the risk of cardiovascular and infection-related deaths were observed according to sex. The risk of mortality due to sudden death, cancer, other, or unknown causes was significantly lower for females than males in the entire population (HR 0.66, 95% CI 0.56-0.78, P < 0.001), in patients on HD (HR 0.75, 95% CI 0.62-0.90, P = 0.003), and in patients on PD (HR 0.49, 95% CI 0.34-0.70, P < 0.001). The survival advantage of females in the general population was maintained in Korean dialysis patients, which was attributed to a lower risk of noncardiovascular and noninfectious death. | Jung, Hee-Yeon; Jeon, Yena; Kim, Yon Su; Kang, Shin-Wook; Yang, Chul Woo; Kim, Nam-Ho; Noh, Hee-Won; Jeon, Soo-Jee; Lim, Jeong-Hoon; Choi, Ji-Young; Cho, Jang-Hee; Park, Sun-Hee; Kim, Chan-Duck; Kim, Yong-Lim | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Nephrol,Kyungpook Natl Univ Hosp, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea; Chonnam Natl Univ, Dept Internal Med, Med Sch, Gwangju, South Korea | Park, Sun-Hee/LMN-0033-2024; Lim, Jeong-Hoon/ABE-6003-2020; Jung, Hee-Yeon/AFB-8578-2022; Cho, Jang-hee/ABD-3534-2020; Kim, Hyoungnae/JXN-1329-2024; Kim, Jong-Ho/R-1602-2017; Kim, Yong-Lim/AGK-3172-2022 | 57196396467; 57209909350; 7410205767; 34768359700; 7407743404; 56605215700; 57219963219; 57219960429; 55360244300; 7501393222; 7403536291; 7501831741; 8558530700; 55633533600 | ylkim@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.78 | 2025-06-25 | 8 | 11 | DISEASE; WOMEN; RISK; GENDER; IMPACT; MEN; SURVIVAL | Cohort Studies; Female; Humans; Kidney Failure, Chronic; Male; Proportional Hazards Models; Prospective Studies; Renal Dialysis; Renal Insufficiency; Risk Factors; adverse event; chronic kidney failure; cohort analysis; female; hemodialysis; human; kidney failure; male; proportional hazards model; prospective study; risk factor | English | 2022 | 2022-11-03 | 10.1038/s41598-022-16163-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Simultaneous measurement of two biological signals using a multi-layered polyvinylidene fluoride sensor | Cardiovascular and deep breathing diseases can be detected by measuring human signals such as heart rate, respiration, and blood pressure, which are important physiological parameters for accessing the state of the body. However, conventionally, heart and respiration rates are monitored using different sensors, which is cumbersome and can further increase the psychological burden on patients. To address these issues, this report proposes a sensor consisting of two stacked elements that can simultaneously measure heart and respiration rates. The two signals received can be expressed separately as heart and respiration rates after signal processing. The two stacked elements are composed of polyvinylidene fluoride thin film bonded to a polydimethylsiloxane substrate. One element (element 1) measures movement related to the heart, and the other (element 2) measures movement related to breathing. Elements 1 and 2 were experimentally observed to have sensitivities of 0.163 V/N and 0.209 V/N, respectively. In addition, the proposed system was compared with a commercial digital heart rate and respiration rate measurement instrument and was verified to be effective for simultaneous measurement of human vital signals with multiple sensors. In addition, the proposed system is flexible, lightweight, and inexpensive, making it convenient and economical. | Manh, Long-Nguyen; Li, Jinghua; Kweon, Hyunkyu; Chae, Younghun | Kumoh Natl Inst Technol, Dept Mech Syst Engn, Gumi Si 39177, South Korea; Kyungpook Natl Univ, Dept Mech Engn, Daegu 41566, South Korea | Li, Jinghua/AGS-4025-2022 | 57434946800; 57434806900; 7004390711; 7101749123 | lijinghua0121@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.43 | 2025-06-25 | 7 | 6 | CHEST-WALL; PVDF; PATCH; FILM | Fluorocarbon Polymers; Polyvinyls; fluorocarbon; polyvinyl derivative; polyvinylidene fluoride | English | 2022 | 2022-01-27 | 10.1038/s41598-022-05622-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
페이지 이동: