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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Etiologies of altered level of consciousness in the emergency room | Altered levels of consciousness (ALCs) is a challenging issue; however, data describing its etiology and frequency are lacking. This study aimed to clarify and classify the etiologies of ALCs in the emergency room (ER) and to evaluate their destinations and the form of discharge. This retrospective study included patients with an ALC who visited the ER of a university hospital between January 2018 and December 2020. The cause and classification of the ALCs were carefully determined by a consortium of board-certified faculty members in emergency medicine, internal medicine, and neurology. The reference point for determining the etiology of ALC was discharge from the ER. In total, 2028 patients with ALCs were investigated. More than half (1037, 51.1%) visited the ER between 9:00 and 18:00. The most common etiology was systemic infection (581, 28.6%), followed by metabolic causes (455, 22.4%), and stroke (271, 13.4%). The two leading etiologies were extracranial and had a majority of the cases (1036, 51.5%). The overall mortality rate was 17.2%. This study provides fundamental information on ALC in the ER. Although intracranial etiologies have been foregrounded, this study demonstrated that extracranial etiologies are the main cause of ALC in the ER. | Kim, Keun Tae; Jeon, Jae Cheon; Jung, Chang-Gyu; Park, Jung A.; Seo, Jong-Geun; Kwon, Doo Hyuk | Keimyung Univ, Dept Neurol, Sch Med, Daegu, South Korea; Keimyung Univ, Dept Emergency Med, Sch Med, Daegu, South Korea; Keimuyung Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Daegu Catholic Univ, Dept Neurol, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu, South Korea; Yeungnam Univ, Dept Neurol, Coll Med, 170 Hyeonchungno, Daegu 42415, South Korea | Kim, Keun Tae/IQU-1105-2023 | 57204465615; 57215830861; 57191478350; 57225162068; 16040307500; 57216938491 | kspy1d@naver.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.5 | 2025-06-25 | 7 | 7 | MENTAL STATUS | Consciousness; Consciousness Disorders; Emergency Service, Hospital; Humans; Patient Discharge; Retrospective Studies; consciousness; consciousness disorder; hospital discharge; hospital emergency service; human; retrospective study | English | 2022 | 2022-03-23 | 10.1038/s41598-022-09110-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Fatigue-free visual perception of high-density super-multiview augmented reality images | It is well known that wearing virtual reality (VR) and augmented reality (AR) devices for long periods can cause visual fatigue and motion sickness due to vergence-accommodation conflict (VAC). VAC is considered the main obstacle to the development of advanced three-dimensional VR and AR technology. In this paper, we present a novel AR high-density super-multiview (HDSMV) display technique capable of eliminating VAC in wide range. The designed binocular time-sequential AR HDSMV projection, which delivers 11 views to each eye pupil, is experimentally demonstrated, confirming that VAC is eliminated over a wide-range of viewer's focus distance. It is believed that the proposed time-sequential AR HDSMV method will pave the way for the development of VAC-free AR technology. | Lim, Sungjin; Jeon, Hosung; Jung, Minwoo; Lee, Chulwoong; Moon, Woonchan; Kim, Kwangsoo; Kim, Hwi; Hahn, Joonku | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Korea Univ, Dept Elect & Informat Engn, Sejong 30019, South Korea | 56706721300; 56663784700; 57216159562; 57190258533; 56340460500; 57188873326; 8933596300; 10142501600 | hwikim@korea.ac.kr;jhahn@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.43 | 2025-06-25 | 6 | 7 | LIGHT-FIELD DISPLAY; 3-DIMENSIONAL DISPLAY; VERGENCE; 3D; DISCOMFORT; CONFLICT | English | 2022 | 2022-02-22 | 10.1038/s41598-022-06778-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Feasibility of targeted cascade genetic testing in the family members of BRCA1/2 gene pathogenic variant/likely pathogenic variant carriers | The pathogenic variant (PV) or likely pathogenic variant (LPV) BRCA1/2 gene is strongly associated with hereditary breast or ovarian cancer. Therefore, it is important to screen blood relatives to establish preventive modalities and surveillance. This study evaluated the feasibility of targeted cascade genetic testing for family members of BRCA1/2 gene PV or LPV carriers. We screened 18 families for BRCA1/2 gene status via the conventional cascade genetic test (n = 9) and targeted cascade genetic test (n = 9), which targeted the exon region wherein the index patient showed PV or LPV. The pedigree and clinicopathologic characteristics were reviewed and analyzed. All index patients were diagnosed with breast cancer, while the third family members were all healthy. In the conventional cascade test group, 3 index patients and 3 family members had the BRCA1/2 gene PV or LPV. In the targeted cascade test group, 5 family members had same type of BRCA1/2 gene PV or LPV as their index patients. Two families had an identical string of BRCA1/2 gene PV or LPV. Although the targeted cascade genetic test cannot completely characterize the BRCA1/2 gene, it is sufficient for determining its PV or LPV status. This limited genetic test can be used for family members of PV or LPV carriers. | Lee, Jeeyeon; Ham, Ji Yeon; Park, Ho Yong; Jung, Jin Hyang; Kim, Wan Wook; Kang, Byeongju; Chae, Yee Soo; Lee, Soo Jung; Lee, In Hee; Lee, Nan Young | Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Clin Pathol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Hemato Oncol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Daegu, South Korea | ; lee, nan/HZM-0321-2023; Lee, Jong-Mok/KVY-9550-2024; PARK, JUN-YOUNG/P-5981-2015 | 37079213100; 56464754800; 56564377200; 57209310173; 26023273400; 57279815300; 57190793908; 57203597252; 57191881516; 57209204358 | leenanyoung70@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.43 | 2025-06-25 | 6 | 6 | OVARIAN-CANCER; HEREDITARY BREAST; MUTATION CARRIERS; SEQUENCE VARIANTS; DECISION; HISTORY; IMPACT; RISKS | BRCA1 Protein; BRCA2 Protein; Breast Neoplasms; Feasibility Studies; Female; Genetic Carrier Screening; Genetic Predisposition to Disease; Genetic Variation; Heredity; Heterozygote; Humans; Male; Pedigree; Phenotype; Predictive Value of Tests; BRCA1 protein; BRCA1 protein, human; BRCA2 protein; BRCA2 protein, human; breast tumor; feasibility study; female; genetic predisposition; genetic variation; genetics; heredity; heterozygote; heterozygote detection; human; male; pathology; pedigree; phenotype; predictive value | English | 2022 | 2022-02-03 | 10.1038/s41598-022-05931-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Flicker-free dual-volume augmented reality display using a pixelated interwoven integral floating technique with a geometric phase lens | A geometric phase (GP) integral floating display can provide multifocal threedimensional (3D) augmented reality (AR) images with enhanced depth expression by switching the focal modes of the GP lens via polarization control. However, using temporal multiplexing to switch between the focal modes of GP optics causes flickering as each 3D AR image is fully presented in different frames and their temporal luminance profile becomes easily recognizable, particularly as the number of available focal modes increases. Here, we propose a novel integral floating technique to generate pixelated interwoven 3D AR images; a half of each image is spatially mixed with another and presented in both focal modes simultaneously to resolve the flickering issue. The principle was verified via experimental demonstration and optically measured data. (c) 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement | Lee, Hyeontaek; Lee, Jae-Won; Shin, JungYeop; Hong, Sunghee; Kim, Hak-Rin; Choi, Hee-Jin | Sejong Univ, Dept Phys, Seoul 05006, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Korea Elect Technol Inst, Seoul 03924, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea | ; Kim, Hak-Rin/T-1897-2019 | 57216647090; 58377059800; 57956975700; 55608796400; 7410124944; 7404340092 | rineey@knu.ac.kr;hjchoi@sejong.ac.kr; | OPTICS EXPRESS | OPT EXPRESS | 1094-4087 | 30 | 23 | SCIE | OPTICS | 2022 | 3.8 | 29.5 | 0.61 | 2025-06-25 | 5 | 6 | NEAR-EYE DISPLAY; DIGITAL HOLOGRAPHY; OPTICAL-ELEMENTS; SENSITIVITY; SYSTEM; ARRAY | Flickering; Image enhancement; Experimental demonstrations; Geometric phase; Integral floating; Multifocal; Polarization control; Temporal multiplexing; article; augmented reality; three-dimensional imaging; Augmented reality | English | 2022 | 2022-11-07 | 10.1364/oe.474795 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Genetic and morphological variation of Vespa velutina nigrithorax which is an invasive species in a mountainous area | The yellow-legged hornet (Vespa velutina nigrithorax) is an invasive species in South Korea with negative economic, ecological, and public health impacts. We investigated genetic and morphological variation in the species populations on Mt. Jiri, the tallest mountain in South Korea. We hypothesized that a high-altitude would be negatively correlated with the genetic diversity of the hornet population, and hornet wing morphology would change with an increase in altitude. Our results showed that the genetic diversity of yellow-legged hornets did not decrease as altitude increased. Regardless of the altitude, the inbreeding coefficient was high at the newly colonized sites. A single genetic population occurred in the mountainous areas examined and gradually expanded its range. Wing morphology, especially shape, did not change with an increase in altitude or decrease in temperature. Although snow cover and cool temperatures at high altitudes could limit nest-building activities, they did not prevent the extension of the range of the species. Therefore, the yellow-legged hornet cannot be controlled naturally by climate or topography; combined approaches, including chemical control, nest removal, and bait-trapping techniques should be implemented. | Do, Yuno; Park, Woong-Bae; Park, Jun-Kyu; Kim, Chang-Jun; Choi, Moon Bo | Kongju Natl Univ, Dept Biol Sci, Gongju, South Korea; Korea Natl Arboretum, Res Panning & Coordinat Team, Pochon, Gyeonggi, South Korea; Kyungpook Natl Univ, Inst Plant Med, Daegu, South Korea | Park, Junkyu/AAE-1509-2020; KIm, Changjun/GZM-7308-2022 | 52163435800; 57537588500; 57216365592; 55286588300; 51863232400 | changjunkim@korea.kr;kosinchoi@hanmail.net; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.36 | 2025-06-25 | 4 | 5 | YELLOW-LEGGED HORNET; HYMENOPTERA VESPIDAE; POPULATION-STRUCTURE; ASIAN HORNET; CONSEQUENCES; SOFTWARE; KOREA; FRAGMENTATION; LEPELETIER; EXPANSION | Animals; Introduced Species; Republic of Korea; Temperature; Wasps; animal; genetics; introduced species; South Korea; temperature; wasp | English | 2022 | 2022-03-18 | 10.1038/s41598-022-08756-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Genomic epidemiology of SARS-CoV-2 Omicron variants in the Republic of Korea | The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic since 2019. Variants of concern (VOCs) declared by the World Health Organization require continuous monitoring because of their possible changes in transmissibility, virulence, and antigenicity. The Omicron variant, a VOC, has become the dominant variant worldwide since November 2021. In the Republic of Korea (South Korea), the number of confirmed cases increased rapidly after the detection of Omicron VOC on November 24, 2021. In this study, we estimated the underlying epidemiological processes of Omicron VOC in South Korea using time-scaled phylodynamic analysis. Three distinct phylogenetic subgroups (Kor-O1, Kor-O2, and Kor-O3) were detected in South Korea. The Kor-O1 subgroup circulated in the Daegu region, whereas Kor-O2 and Kor-O3 circulated in Incheon and Jeollanam-do, respectively. The viral population size and case number of the Kor-O1 subgroup increased more rapidly than those of the other subgroups, indicating the rapid spread of the virus. The results indicated the multiple introductions of Omicron sub-lineages into South Korea and their subsequent co-circulation. The evolution and transmission of SARS-CoV-2 should be continuously monitored, and control strategies need to be improved to control the multiple variants. | Lee, Dong-Wook; Kim, Jeong-Min; Park, Ae Kyung; Kim, Da-Won; Kim, Ji-Yun; Lim, Noori; Lee, Hyeokjin; Kim, Il-Hwan; Kim, Jeong-Ah; Lee, Chae Young; Kwon, Jung-Hoon; Kim, Eun-Jin | Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Korea Dis Control & Prevent Agcy, Div Emerging Infect Dis, Bur Infect Dis Diag Control, Cheongju 28159, South Korea | ; Park, Sue/J-2757-2012 | 57711484300; 57203325163; 57210753537; 57299949900; 57299583700; 57299583800; 57207324810; 57207979541; 57365772200; 57222424110; 55559800200; 57225870516 | Junghoon.kwon@knu.ac.kr;ekim@korea.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 1.35 | 2025-06-25 | 18 | 19 | COVID-19; Genomics; Humans; Phylogeny; Republic of Korea; SARS-CoV-2; epidemiology; genetics; genomics; human; phylogeny; South Korea | English | 2022 | 2022-12-27 | 10.1038/s41598-022-26803-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Human magnetic sense is mediated by a light and magnetic field resonance-dependent mechanism | Numerous organisms use the Earth's magnetic field as a sensory cue for migration, body alignment, or food search. Despite some contradictory reports, yet it is generally accepted that humans do not sense the geomagnetic field. Here, we demonstrate that a magnetic field resonance mechanism mediates light-dependent magnetic orientation in men, using a rotary chair experiment combined with a two-alternative forced choice paradigm. Two groups of subjects were classified with different magnetic orientation tendencies depending on the food context. Magnetic orientation of the subjects was sensitive to the wavelength of incident light and was critically dependent on blue light reaching the eyes. Importantly, it appears that a magnetic field resonance-dependent mechanism mediates these responses, as evidenced by disruption or augmentation of the ability to orient by radiofrequency magnetic fields at the Larmor frequency and the dependence of these effects on the angle between the radiofrequency and geomagnetic fields. Furthermore, inversion of the vertical component of the geomagnetic field revealed a non-canonical inclination compass effect on the magnetic orientation. These results establish the existence of a human magnetic sense and suggest an underlying quantum mechanical magnetoreception mechanism. | Chae, Kwon-Seok; Kim, Soo-Chan; Kwon, Hye-Jin; Kim, Yongkuk | Kyungpook Natl Univ, Dept Biol Educ, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Nanosci & Nanotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41566, South Korea; Hankyong Natl Univ, Res Ctr Appl Human Sci, Dept Elect & Elect Engn, Anseong 17579, South Korea; Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea | 15743626400; 55974550600; 57213653536; 7410204041 | kschae@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.78 | 2025-06-25 | 9 | 11 | RADICAL-PAIR MECHANISM; COMPASS ORIENTATION; MAGNETORECEPTION; CRYPTOCHROME; BIRDS; SUPEROXIDE | Humans; Magnetic Fields; Magnetics; Male; Orientation; Radio Waves; Vibration; adult; article; blue light; case report; clinical article; human; human experiment; magnetic field; magnetoreceptor; male; radiofrequency; two alternative forced choice; magnetism; orientation; physiology; radiofrequency radiation; vibration | English | 2022 | 2022-05-30 | 10.1038/s41598-022-12460-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Hybrid selection based multi/many-objective evolutionary algorithm | In the last decade, numerous multi/many-objective evolutionary algorithms (MOEAs) have been proposed to handle multi/many-objective problems (MOPs) with challenges such as discontinuous Pareto Front (PF), degenerate PF, etc. MOEAs in the literature can be broadly divided into three categories based on the selection strategy employed such as dominance, decomposition, and indicator-based MOEAs. Each category of MOEAs have their advantages and disadvantages when solving MOPs with diverse characteristics. In this work, we propose a Hybrid Selection based MOEA, referred to as HS-MOEA, which is a simple yet effective hybridization of dominance, decomposition and indicator-based concepts. In other words, we propose a new environmental selection strategy where the Pareto-dominance, reference vectors and an indicator are combined to effectively balance the diversity and convergence properties of MOEA during the evolution. The superior performance of HS-MOEA compared to the state-of-the-art MOEAs is demonstrated through experimental simulations on DTLZ and WFG test suites with up to 10 objectives. | Dutta, Saykat; Mallipeddi, Rammohan; Das, Kedar Nath | Natl Inst Technol Silchar, Dept Math, Silchar, India; Kyungpook Natl Univ, Sch Elect Engn, Dept Artificial Intelligence, Daegu, South Korea | Mallipeddi, Rammohan/AAL-5306-2020; Dutta, Saykat/ABE-3044-2021 | 57204580655; 25639919900; 55220472200 | mallipeddi.ram@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.57 | 2025-06-25 | 9 | 8 | NONDOMINATED SORTING APPROACH; OPTIMIZATION; PERFORMANCE; MOEA/D | article; decomposition; evolutionary algorithm; simulation | English | 2022 | 2022-04-27 | 10.1038/s41598-022-10997-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Identification of noble candidate gene associated with sensitivity to phytotoxicity of etofenprox in soybean | Phytotoxicity is caused by the interaction between plants and a chemical substance, which can cause critical damage to plants. Understanding the molecular mechanism underlying plant-chemical interactions is important for managing pests in crop fields and avoiding plant phytotoxicity by insecticides. The genomic region responsible for sensitivity to phytotoxicity of etofenprox (PE), controlled by a single dominant gene, was detected by constructing high density genetic map using recombination inbred lines (RILs) in soybean. The genomic region of similar to 80 kbp containing nine genes was identified on chromosome 16 using a high-throughput single nucleotide polymorphism (SNP) genotyping system using two different RIL populations. Through resequencing data of 31 genotypes, nonsynonymous SNPs were identified in Glyma.16g181900, Glyma.16g182200, and Glyma.16g182300. The genetic variation in Glyma.16g182200, encoding glycosylphosphatidylinositol-anchored protein (GPI-AP), caused a critical structure disruption on the active site of the protein. This structural variation of GPI-AP may change various properties of the ion channels which are the targets of pyrethroid insecticide including etofenprox. This is the first study that identifies the candidate gene and develops SNP markers associated with PE. This study would provide genomic information to understand the mechanism of phytotoxicity in soybean and functionally characterize the responsive gene. | Kim, Ji-Min; Ha, Jungmin; Shin, Ilseob; Lee, Ju Seok; Park, Jung-Ho; Lee, Jeong-Dong; Kang, Sungteag | Dankook Univ, Dept Crop Sci & Biotechnol, Cheonan 31116, South Korea; Gangneung Wonju Natl Univ, Dept Plant Sci, Kangnung 25457, South Korea; Korea Res Inst Biosci & Biotechnol, Bioevaluat Ctr, Cheongju 28116, South Korea; Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea | Ha, Jungmin/JAC-1760-2023 | 57211517085; 57203884327; 57223439186; 57871955400; 36546514200; 40462075100; 9736708500 | kangst@dankook.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0 | 2025-06-25 | 0 | 0 | GPI-ANCHORED PROTEINS; LETTUCE PHYSIOLOGY; SODIUM-CHANNELS; EXPRESSION | English | 2022 | 2022-09-02 | 10.1038/s41598-022-19323-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Immobilised teicoplanin does not demonstrate antimicrobial activity against Staphylococcus aureus | Antibacterial bone biomaterial coatings appeal to orthopaedics, dentistry and veterinary medicine. Achieving the successful, stable conjugation of suitable compounds to biomaterial surfaces is a major challenge. A pragmatic starting point is to make use of existing, approved antibiotics which are known to remain functional in a stationary, immobilised state. This includes the macrocyclic glycopeptide, teicoplanin, following the discovery, in the 1990's, that it could be used as a chiral selector in chromatographic enantiomeric separations. Importantly teicoplanin works at the level of the bacterial cell wall making it a potential candidate for biomaterial functionalisations. We initially sought to functionalise titanium (Ti) with polydopamine and use this platform to capture teicoplanin, however we were unable to avoid the natural affinity of the antibiotic to the oxide surface of the metal. Whilst the interaction between teicoplanin and Ti was robust, we found that phosphate resulted in antibiotic loss. Before contemplating the covalent attachment of teicoplanin to Ti we examined whether a commercial teicoplanin stationary phase could kill staphylococci. Whilst this commercially available material could bind N-Acetyl-L-Lys-D-Ala-D-Ala it was unable to kill bacteria. We therefore strongly discourage attempts at covalently immobilising teicoplanin and/or other glycopeptide antibiotics in the pursuit of novel antibacterial bone biomaterials. | Britton, S.; Lee, K.; Azizova, L.; Shaw, G.; Ayre, W. Nishio; Mansell, J. P. | Univ West England, Dept Appl Sci, Coldharbour Lane, Bristol BS16 1QY, Avon, England; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Dept Chem, Daegu 41566, South Korea; Cardiff Univ, Sch Dent, Cardiff CF14 4XY, Wales | 57916740000; 56404800600; 24765997300; 57916936600; 56008200000; 7005775374 | Jason.mansell@uwe.ac.uk; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.07 | 2025-06-25 | 0 | 1 | CHIRAL STATIONARY PHASES; LIQUID-CHROMATOGRAPHY; ANTIBIOTICS; PERFORMANCE; SEPARATION; ACIDS; HPLC | Anti-Bacterial Agents; Biocompatible Materials; Chromatography, High Pressure Liquid; Glycopeptides; Oxides; Phosphates; Staphylococcus aureus; Teicoplanin; Titanium; antiinfective agent; biomaterial; glycopeptide; oxide; phosphate; teicoplanin; titanium; chemistry; high performance liquid chromatography; procedures; Staphylococcus aureus | English | 2022 | 2022-10-05 | 10.1038/s41598-022-20310-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Impact on capsule formation for three different types of implant surface tomography | Although capsular contracture remains one of the major problems following silicone breast implantation, the associated mechanism has yet to be determined. This study thus aimed to investigate capsule formation and capsular contracture using three types of implants with different surface topographies in vivo. Three types of implants (i.e., smooth, macrotexture, and nanotexture) with different surface topographies were inserted in a total of 48 Wistar rats. After 4 and 12 weeks, the samples were analyzed via histological, immunohistochemical, and Western blot examination. To identify implant movement, the degree to which implant position changed was measured. And the surface topography was characterized using scanning electron microscopy. Hematoxylin-eosin staining showed that the nanotexture type implant promoted significant decreases in capsule thickness at 12 weeks (P < 0.05), while Masson trichrome staining showed decreased collagen fiber density with the same implant type. Immunohistochemical and Western blot examination revealed reduced fibrosis markers (myofibroblast, and transforming growth factor beta-1) in the nanotexture surface implant. Meanwhile, implant location evaluation found that the nanotexture and smooth surface implants had significantly increased movement (P < 0.05). The nanotexture surface implant had been found to reduce capsule formation given that it minimizes the effects of factors related to foreign body reaction. | Jeon, Hyeon Jun; Kang, MyeongJae; Lee, Joon Seok; Kang, Jieun; Kim, Eun A.; Jin, Hee Kyung; Bae, Jae-sung; Yang, Jung Dug | Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, 130 Dongdeok Ro, Daegu 700421, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Exosome Convergence Res Ctr, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Lab Anim Med, Daegu, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Dept Physiol, Sch Med, Daegu, South Korea | Yang, Jung/R-7806-2019; LEE, JIN/Q-3108-2018; Kim, Young/T-8521-2019; Bae, Jae-sung/AAM-8663-2021 | 57201068256; 57445997600; 56496041000; 57212252058; 55241586600; 8088145800; 35209510400; 55171704700 | lambyang@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.99 | 2025-06-25 | 14 | 14 | SILICONE BREAST IMPLANTS; CONTRACTURE; AUGMENTATION; TOPOGRAPHY | Animals; Breast Implantation; Breast Implants; Contracture; Rats; Rats, Wistar; Tomography; adverse device effect; animal; breast augmentation; breast endoprosthesis; contracture; rat; tomography; Wistar rat | English | 2022 | 2022-08-08 | 10.1038/s41598-022-17320-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | In vivo evaluation of the effects of combined boron and gadolinium neutron capture therapy in mouse models | While boron neutron capture therapy (BNCT) depends primarily on the short flight range of the alpha particles emitted by the boron neutron capture reaction, gadolinium neutron capture therapy (GdNCT) mainly relies on gamma rays and Auger electrons released by the gadolinium neutron capture reaction. BNCT and GdNCT can be complementary in tumor therapy. Here, we studied the combined effects of BNCT and GdNCT when boron and gadolinium compounds were co-injected, followed by thermal neutron irradiation, and compared these effects with those of the single therapies. In cytotoxicity studies, some additive effects (32-43%) were observed when CT26 cells were treated with both boron- and gadolinium-encapsulated PEGylated liposomes (B- and Gd-liposomes) compared to the single treatments. The tumor-suppressive effect was greater when BNCT was followed by GdNCT at an interval of 10 days rather than vice versa. However, tumor suppression with co-injection of B- and Gd-liposomes into tumor-bearing mice followed by neutron beam irradiation was comparable to that observed with Gd-liposome-only treatment but lower than B-liposome-only injection. No additive effect was observed with the combination of BNCT and GdNCT, which could be due to the shielding effect of gadolinium against thermal neutrons because of its overwhelmingly large thermal neutron cross section. | Lee, Woonghee; Kim, Kyung Won; Lim, Jeong Eun; Sarkar, Swarbhanu; Kim, Jung Young; Chang, Yongmin; Yoo, Jeongsoo | Kyungpook Natl Univ, Dept Mol Med, Brain Korea 21 Four KNU Convergence Educ Program, Sch Med, Daegu 41944, South Korea; Korea Inst Radiol & Med Sci, Div Appl RI, Seoul 01812, South Korea | ; Sarkar, Swarbhanu/ISS-1138-2023; Kim, Soon Hee/GXF-6736-2022; Kim, Kyunghoon/AGO-0079-2022 | 55881469700; 57733158200; 57732661800; 36603493100; 7601371677; 7501840633; 8215136400 | yooj@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.71 | 2025-06-25 | 9 | 10 | NANOPARTICLES; GDNCT; AGENT | Animals; Boron; Boron Compounds; Disease Models, Animal; Gadolinium; Liposomes; Mice; Neoplasms; Neutron Capture Therapy; boron; boron derivative; gadolinium; liposome; animal; disease model; mouse; neoplasm; neutron capture therapy | English | 2022 | 2022-08-03 | 10.1038/s41598-022-17610-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Influence of cerebral microbleeds on mechanical thrombectomy outcomes | In ischemic stroke patients undergoing endovascular treatment (EVT), we aimed to test the hypothesis that cerebral microbleeds (CMBs) are associated with clinical outcomes, while estimating the mediating effects of hemorrhagic transformation (HT), small-vessel disease burden (white matter hyperintensities, WMH), and procedural success. From a multicenter EVT registry, patients who underwent pretreatment MR imaging were analyzed. They were trichotomized according to presence of CMBs (none vs. 1-4 vs. >= 5). The association between CMB burden and 3-month mRS was evaluated using multivariable ordinal logistic regression, and mediation analyses were conducted to estimate percent mediation. Of 577 patients, CMBs were present in 91 (15.8%); 67 (11.6%) had 1-4 CMBs, and 24 (4.2%) had >= 5. Increases in CMBs were associated with hemorrhagic complications (beta = 0.27 [0.06-0.047], p = 0.010) in multivariable analysis. The CMB effect on outcome was partially mediated by post-procedural HT degree (percent mediation, 14% [0-42]), WMH (23% [7-57]) and lower rates of successful reperfusion (6% [0-25]). In conclusion, the influence of CMBs on clinical outcomes is mediated by small-vessel disease burden, post-procedural HT, and lower reperfusion rates, listed in order of percent mediation size. | Lee, Seong-Joon; Hwang, Yang-Ha; Hong, Ji Man; Choi, Jin Wook; Park, Ji Hyun; Park, Bumhee; Kang, Dong-Hun; Kim, Yong-Won; Kim, Yong-Sun; Hong, Jeong-Ho; Yoo, Joonsang; Kim, Chang-Hyun; Sohn, Sung-Il; Lee, Jin Soo | Ajou Univ, Med Ctr, Dept Neurol, Sch Med, 164,World Cup Ro, Suwon 16499, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu, South Korea; Ajou Univ, Med Ctr, Dept Radiol, Sch Med, Suwon, South Korea; Ajou Univ, Ajou Res Inst Innovat Med, Off Biostat, Med Ctr, Suwon, South Korea; Ajou Univ, Dept Biomed Informat, Sch Med, Suwon, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea; Keimyung Univ, Dept Neurol, Dongsan Med Ctr, Daegu, South Korea; Yonsei Univ, Yongin Severance Hosp, Dept Neurol, Coll Med, Yongin, South Korea; Keimyung Univ, Dept Neurosurg, Dongsan Med Ctr, Daegu, South Korea | HWANG, Yang-Ha/F-3068-2013; Kim, Chang-Hyun/I-5166-2012; Hong, Ji Man/AAE-2686-2022; Hong, Jeong-Ho/T-8099-2018; Park, Ji/ABG-5893-2020 | 57218256679; 7402311308; 55729426200; 55722501000; 57192071799; 57205620923; 8977805800; 56203298200; 57095278300; 55931654800; 55261162200; 56059033400; 36479287000; 55963063300 | jinsoo22@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.78 | 2025-06-25 | 12 | 11 | ACUTE ISCHEMIC-STROKE; INTRACEREBRAL HEMORRHAGE; ENDOVASCULAR THROMBECTOMY; RISK; THERAPY; THROMBOLYSIS; MANAGEMENT; BURDEN | Cerebral Hemorrhage; Humans; Magnetic Resonance Imaging; Stroke; Thrombectomy; adverse event; brain hemorrhage; cerebrovascular accident; clinical trial; complication; human; multicenter study; nuclear magnetic resonance imaging; procedures; thrombectomy | English | 2022 | 2022-03-07 | 10.1038/s41598-022-07432-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Integrated analysis of expression profiles with meat quality traits in cattle | MicroRNAs (miRNAs) play a vital role in improving meat quality by binding to messenger RNAs (mRNAs). We performed an integrated analysis of miRNA and mRNA expression profiling between bulls and steers based on the differences in meat quality traits. Fat and fatty acids are the major phenotypic indices of meat quality traits to estimate between-group variance. In the present study, 90 differentially expressed mRNAs (DEGs) and 18 differentially expressed miRNAs (DEMs) were identified. Eighty-three potential DEG targets and 18 DEMs were used to structure a negative interaction network, and 75 matching target genes were shown in this network. Twenty-six target genes were designated as intersection genes, screened from 18 DEMs, and overlapped with the DEGs. Seventeen of these genes enriched to 19 terms involved in lipid metabolism. Subsequently, 13 DEGs and nine DEMs were validated using quantitative real-time PCR, and seven critical genes were selected to explore the influence of fat and fatty acids through hub genes and predict functional association. A dual-luciferase reporter and Western blot assays confirmed a predicted miRNA target (bta-miR-409a and PLIN5). These findings provide substantial evidence for molecular genetic controls and interaction among genes in cattle. | Li, Yunxiao; Yang, Miaosen; Lou, Angang; Yun, Jinyan; Ren, Chunyu; Li, Xiangchun; Xia, Guangjun; Nam, Kichang; Yoon, Duhak; Jin, Haiguo; Seo, Kangseok; Jin, Xin | Shandong Univ, Coll Life Sci, Qingdao, Peoples R China; Yanbian Univ, Engn Res Ctr North East Cold Reg Beef Cattle Sci, Minist Educ, Yanji, Peoples R China; Yanbian Univ, Coll Agr, Dept Vet Med, Yanji, Peoples R China; Sunchon Natl Univ, Coll Life Sci & Nat Resources, Dept Anim Sci & Technol, Sunchon, South Korea; Northeast Elect Power Univ, Dept Chem, Jilin, Jilin, Peoples R China; Kyungpook Natl Univ, Dept Anim Sci, Taegu, South Korea; Jilin Acad Agr Sci, Branch Anim, Changchun, Peoples R China; Jilin Agr Sci & Technol Univ, Coll Anim Sci & Technol, Jilin, Jilin, Peoples R China; Anim Husb Bur Yanbian Autonomous Prefecture, Yanji, Peoples R China | jin, xin/KWU-0198-2024; Xia, Guangjun/AAH-1999-2020 | 57541052700; 57540093400; 57195310659; 57202494541; 57568214500; 57567219800; 57211447317; 7203003221; 7202875754; 27168340700; 57212114159; 56207063800 | sks@sunchon.ac.kr;jinxin@ybu.edu.cn; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.57 | 2025-06-25 | 11 | 9 | INTRAMUSCULAR FAT-CONTENT; ACID-COMPOSITION; GENE-EXPRESSION; SUBCUTANEOUS FAT; SKELETAL-MUSCLE; ADIPOSE-TISSUE; MICRORNA; BEEF; RNA; IDENTIFICATION | Animals; Cattle; Fatty Acids; Gene Expression Profiling; Gene Regulatory Networks; Male; Meat; MicroRNAs; RNA, Messenger; fatty acid; messenger RNA; microRNA; animal; bovine; gene expression profiling; gene regulatory network; genetics; male; meat; metabolism | English | 2022 | 2022-04-08 | 10.1038/s41598-022-09998-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Investigation of ultra-precision planing process to fabricate high luminance retroreflector based on cutting force and tool vibration analysis | In ultra-precision planing process, the analysis of the critical depth of cut (DOC) is required to reduce the edge blunt and micro burrs produced by size effect which decreases of the effective area for high luminance retroreflector. However, since the machining characteristics are different according to cutting tool shape, machining material, and cutting condition, determine of the critical DOC is difficult without a comparison of machined surfaces under various DOC measured by ultra-high resolution measuring instrument. In this study, the critical DOC was analyzed using cutting force and tool vibration signals. The specific cutting energy was calculated by cutting force and cross-sectional area to analyze the stress variation according to DOC. Also, acceleration signals were converted to frequency spectrum that analyze dominant vibrating direction of the cutting tool by variation of cutting characteristic. It was confirmed that the method of using tool vibration more effective and accurate than specific cutting energy through validation of the comparison between results from analyze of the vibration signals and direction measuring surfaces. The master mold with area of 250 mm(2) was manufactured by applying analyzed critical DOC. In addition, the high luminance characteristic of a retroreflection film press formed by the master mold was confirmed. | Jeong, Ji-Young; Han, Jun Sae; Kang, Chung-Mo; Gwak, Eun-Ji; Choi, Doo-Sun; Je, Tae-Jin | Univ Sci & Technol UST, Dept Nano Mechatron Engn, Daejeon 34113, South Korea; Korea Inst Machinery & Mat KIMM, Dept Nano Mfg Technol, Daejeon 34103, South Korea; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea | 57155608700; 56601929700; 57668081000; 55849645300; 8964570800; 6508127137 | jtj@kimm.re.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0 | 2025-06-25 | 0 | 0 | SYSTEM | acceleration; article; luminance; physiological stress; vibration | English | 2022 | 2022-05-09 | 10.1038/s41598-022-10824-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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