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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Bifurcation phenomena in Taylor-Couette flow in a very short annulus with radial through-flow | In this study, the non-linear dynamics of Taylor-Couette flow in a very small-aspect-ratio wide-gap annulus in a counter-rotating regime under the influence of radial through-flow are investigated by solving its full three-dimensional Navier-Stokes equations. Depending on the intensity of the radial flow, either an axisymmetric (pure m=0 mode) pulsating flow structure or an axisymmetric axially propagating vortex will appear subcritical, i.e. below the centrifugal instability threshold of the circular Couette flow. We show that the propagating vortices can be stably existed in two separate parameter regions, which feature different underlying dynamics. Although in one regime, the flow appears only as a limit cycle solution upon which saddle-node-invariant-circle bifurcation occurs, but in the other regime, it shows more complex dynamics with richer Hopf bifurcation sequences. That is, by presence of incommensurate frequencies, it can be appeared as 1-, 2- and 3-torus solutions, which is known as the Ruelle-Takens-Newhouse route to chaos. Therefore, the observed bifurcation scenario is the Ruelle-Takens-Newhouse route to chaos and the period doubling bifurcation, which exhibit rich and complex dynamics. | Altmeyer, Sebastian; Sankar, M.; Do, Younghae | Univ Politecn Cataluna, Castelldefels Sch Telecom & Aerosp Engn, Barcelona 08034, Spain; Univ Technol & Appl Sci, Dept Gen Requirement, Ibri 516, Oman; Kyungpook Natl Univ, KNU Ctr Nonlinear Dynam, Dept Math, Daegu 41566, South Korea | Do, Younghae/G-3522-2011 | 57201593080; 6701530391; 7103101109 | yhdo@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.14 | 2025-06-25 | 1 | 2 | ROTATING POROUS CYLINDERS; HYDRODYNAMIC STABILITY; FILTRATION; VORTEX; INSTABILITY; DYNAMICS; ONSET | article; nonlinear system; pulsatile flow | English | 2022 | 2022-12-21 | 10.1038/s41598-022-26645-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Article | Comparison of early and late Pneumocystis jirovecii Pneumonia in kidney transplant patients: the Korean Organ Transplantation Registry (KOTRY) Study | Late Pneumocystis jirovecii pneumonia (PJP) is not rare in the era of universal prophylaxis after kidney transplantation. We aimed to determine the nationwide status of PJP prophylaxis in Korea and compare the incidence, risk factors, and outcomes of early and late PJP using data from the Korean Organ Transplantation Registry (KOTRY), a nationwide Korean transplant cohort. We conducted a retrospective analysis using data of 4,839 kidney transplant patients from KOTRY between 2014 and 2018, excluding patients who received multi-organ transplantation or were under 18 years old. Cox regression analysis was performed to determine risk factors for early and late PJP. A total of 50 patients developed PJP. The number of patients who developed PJP was same between onset before 6 months and onsets after 6 months. There were no differences in the rate, duration, or dose of PJP prophylaxis between early and late PJP. Desensitization, higher tacrolimus dose at discharge, and acute rejection were associated with early PJP. In late PJP, old age as well as acute rejection were significant risk factors. In conclusion late PJP is as common and risky as early PJP and requires individualized risk-based prophylaxis, such as prolonged prophylaxis for old patients with a history of rejection. © 2022, The Author(s). | Lee, Gongmyung; Koo, Tai Yeon; Kim, Hyung Woo; Lee, Dong Ryeol; Lee, Dong Won; Oh, Jieun; Kim, Beom Seok; Kim, Myoung Soo; Yang, Jaeseok; Kim, Myoung Soo; Kong, Jin Min; Kwon, Oh Jung; Kim, Deok Gie; Jung, Cheol Woong; Kim, Yeong Hoon; Kim, Joong Kyung; Kim, Chan-Duck; Min, Ji Won; Lee, Sik; Park, Yeon Ho; Park, Jae Berm; Park, Jung Hwan; Park, Jong-Won; Ban, Tae Hyun; Song, Sang Heon; Song, Seung Hwan; Shin, Ho Sik; Yang, Chul Woo; Yoon, Hye Eun; Lee, Kang Wook; Lee, Sang-Ho; Lee, Su Hyung; Lee, Yu Ho; Lee, Jung Pyo; Lee, Jeong-Hoon; Jeon, Jin Seok; Jun, Heungman; Jeong, Kyung Hwan; Chung, Ku Yong; Lee, Jong Soo; Ki, Ju Man; Chae, Dong-Wan; Choi, Soo Jin Na; Shin, Sung; Han, Seungyeup; Huh, Kyu Ha | Division of Nephrology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea; Division of Nephrology, Department of Internal Medicine, Korea University Anam Hospital, Seoul, South Korea; Division of Nephrology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea; Department of Internal Medicine, Maryknoll Medical Center, Pusan, South Korea; Department of Internal Medicine, Pusan National University School of Medicine, Pusan, South Korea; Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea; Division of Nephrology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea; Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea; Division of Nephrology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea; Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea; Department of Nephrology, BHS Hanseo Hospital, Pusan, South Korea; Department of Surgery, College of Medicine, Han Yang University, Seoul, South Korea; Department of Surgery, Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, Wonju, South Korea; Department of Surgery, Korea University Anam Hospital, Seoul, South Korea; Department of Internal Medicine, Inje University Busan Paik Hospital, Pusan, South Korea; Department of Internal Medicine, Bongseng Memorial Hospital, Pusan, South Korea; Department of Internal Medicine, School of Medicine, Kyungpook National University Hospital, Daegu, South Korea; Division of Nephrology, Department of Internal Medicine, Bucheon St. Mary’s Hospital, Bucheon, South Korea; Department of Internal Medicine, Jeonbuk National University Hospital, Jeonju, South Korea; Department of Surgery, Gil Medical Center, Gachon University College of Medicine, Incheon, South Korea; Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Suwon, South Korea; Department of Nephrology, Konkuk University School of Medicine, Seoul, South Korea; Department of Nephrology, Yeungnam University Hospital, Daegu, South Korea; Division of Nephrology, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, Seoul, South Korea; Department of Internal Medicine, Pusan National University Hospital, Pusan, South Korea; Department of Surgery, Ewha Womans University Seoul Hospital, Seoul, South Korea; Department of Internal Medicine, Division of Nephrology, Kosin University College of Medicine, Pusan, South Korea; Division of Nephrology, Department of Internal Medicine, Seoul St. Mary’s Hospital, Seoul, South Korea; Department of Internal Medicine, College of Medicine, Incheon St. Mary’s Hospital, The Catholic University of Korea College of Medicine, Bucheon, South Korea; Department of Nephrology, Chungnam National University Hospital, Daejeon, South Korea; Department of Nephrology, Kyung Hee University Hospital at Gangdong, Seoul, South Korea; Department of Surgery, Ajou University School of Medicine, Suwon, South Korea; Division of Nephrology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, South Korea; Department of Nephrology, SMG-SNU Boramae Medical Center, Seoul, South Korea; Department of Surgery, Myongji Hospital, Goyang, South Korea; Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, South Korea; Department of Surgery, Inje University Ilsan Paik Hospital, Goyang, South Korea; Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, South Korea; Department of Surgery, Ewha Womans University Mokdong Hospital, Seoul, South Korea; Department of Surgery, Ulsan University Hospital, Ulsan, South Korea; Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea; Division of Nephrology, Seoul National University Bundang Hospital, Seoul, South Korea; Department of Surgery, Chonnam National University Medical School, Gwangju, South Korea; Department of Surgery, Asan Medical Center, Seoul, South Korea; Department of Internal Medicine, Keimyung University School of Medicine, Daegu, South Korea; Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea | 57761623500; 25646406800; 57226441883; 57218150487; 57199467944; 8409118400; 56127911000; 35268871600; 57212326527; 59073802900; 7202290990; 57252511100; 57198637675; 7402016375; 7410196419; 56508055400; 8558530700; 56212607100; 57192521521; 57189388760; 13605451500; 56682283600; 54955660800; 56119751700; 36162581500; 57226657760; 57216238599; 7407743404; 57737628900; 7501514537; 55890136000; 57307240100; 56344334200; 56028990400; 57218629097; 36120293400; 55508260600; 8443579300; 24773386100; 57201264463; 57220162686; 23471686900; 35784016900; 56160996300; 24281360600; 35183155900 | jcyjs@yuhs.ac; | Scientific Reports | SCI REP-UK | 2045-2322 | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.5 | 2025-06-25 | 7 | Adolescent; Humans; Kidney Transplantation; Organ Transplantation; Pneumocystis carinii; Pneumonia, Pneumocystis; Registries; Retrospective Studies; adolescent; adverse event; human; kidney transplantation; organ transplantation; Pneumocystis carinii; Pneumocystis pneumonia; register; retrospective study | English | Final | 2022 | 10.1038/s41598-022-14580-5 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Comparison of the gut microbiome of sacbrood virus-resistant and -susceptible Apis cerana from South Korea | Honey bees are important pollinators for the conservation of the ecosystem and agricultural products and provide a variety of products important for human use, such as honey, pollen, and royal jelly. Sacbrood disease (SD) is a devastating viral disease in Apis cerana; an effective preventive measure for SD is urgently needed. In this study, the relationship between the gut microbiome of honey bees and SD was investigated by pyrosequencing. Results revealed that sacbrood virus (SBV)-resistant A. cerana strains harbour a unique acetic acid bacterium, Bombella intestini, and the lactic acid bacteria (LAB) Lactobacillus (unclassified)ᵤc, Bifidobacterium longum, B. catenulatum, Lactococcus lactis, and Leuconostoc mesenteroides in larvae and Hafnia alvei, B. indicum, and the LAB L. mellifer and Lactobacillus HM215046ₛ in adult bees. Changes in the gut microbiome due to SBV infection resulted in loss of bacteria that could affect host nutrients and inhibit honey bee pathogens, such as Gilliamella JFONₛ, Gilliamellaᵤc, Pseudomonas putida, and L. kunkeei in A. cerana larvae and Frischellaᵤc, Pantoea agglomerans, Snodgrassellaᵤc, and B. asteroides in adult bees. These findings provide important information for the selection of probiotics for A. cerana larvae and adults to prevent pathogenic infections and keep honey bees healthy. | Yun, Bo-Ram; Truong, A-Tai; Choi, Yong Soo; Lee, Man Young; Kim, Byoung Yong; Seo, Minjung; Yoon, Soon-Seek; Yoo, Mi-Sun; Van Quyen, Dong; Cho, Yun Sang | Anim & Plant Quarantine Agcy, Bacterial Dis Div, Parasit & Insect Dis Lab, Dept Anim & Plant Hlth Res, Gimcheon 39660, South Korea; Natl Inst Agr Sci, Dept Agr Biol, Wonju 55365, South Korea; ChunLab Inc, Seoul 06194, South Korea; Vietnam Acad Sci & Technol, Univ Sci & Technol Ha Noi, 18 Hoang Quoc Viet, Hanoi, Vietnam; Korea Dis Control & Prevent Agcy, Div Vectors & Parasit Dis, 187 Osongsaengmyeong 2 Ro, Cheongju 28159, Chungbuk, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Med, Daegu 41566, South Korea; Thai Nguyen Univ Sci, Fac Biotechnol, Thai Nguyen 250000, Vietnam | Lee, Jeong Won/AAC-4169-2022; Truong, A-Tai/GLU-9752-2022; Cho, Yun Sang/ACA-6165-2022 | 57200184586; 57204063883; 56204087700; 56053174700; 57744004000; 57744082100; 9838890500; 57217039464; 6504349432; 16066666200 | msyoo99@korea.kr;dvquen@gmail.com;choys@korea.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.92 | 2025-06-25 | 13 | 13 | COMPLETE GENOME SEQUENCE; HONEY-BEE; MELLIFERA L.; SP NOV.; PHYLOGENETIC ANALYSIS; GEN. NOV.; BACTERIA; CULTIVATION; PREVALENCE; STRAINS | Animals; Bacteria; Bees; Disease Susceptibility; Ecosystem; Gastrointestinal Microbiome; Larva; RNA Viruses; Virus Diseases; animal; bacterium; bee; disease predisposition; ecosystem; genetics; intestine flora; larva; RNA virus; virus infection | English | 2022 | 2022-06-15 | 10.1038/s41598-022-13535-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Convolutional neural network-based reconstruction for positronium annihilation localization | A novel hermetic detector composed of 200 bismuth germanium oxide crystal scintillators and 393 channel silicon photomultipliers has been developed for positronium (Ps) annihilation studies. This compact 4 pi detector is capable of simultaneously detecting gamma-ray decay in all directions, enabling not only the study of visible and invisible exotic decay processes but also tumor localization in positron emission tomography for small animals. In this study, we investigate the use of a convolutional neural network (CNN) for the localization of Ps annihilation synonymous with tumor localization. Two-gamma decay systems of the Ps annihilation from Na-22 and F-18 radioactive sources are simulated using a GEANT4 simulation. The simulated datasets are preprocessed by applying energy cutoffs. The spatial error in the XY plane from the CNN is compared to that from the classical weighted k-means algorithm centroiding, and the feasibility of CNN-based Ps annihilation reconstruction with tumor localization is discussed. | Jegal, Jin; Jeong, Dongwoo; Seo, Eun-Suk; Park, HyeoungWoo; Kim, Hongjoo | Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Univ Maryland, Dept Phys, College Pk, MD 20742 USA | Kim, Hong Joo/AAE-1178-2022; , ES/AAN-2324-2020 | 57192238874; 57221047608; 7005953753; 58950744700; 59051568100 | hyeoung87@gmail.com;hongjoo@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.28 | 2025-06-25 | 4 | 4 | LIFETIME SPECTROSCOPY | Animals; Computer Simulation; Neoplasms; Neural Networks, Computer; Positron-Emission Tomography; Tomography, X-Ray Computed; animal; computer simulation; neoplasm; positron emission tomography; procedures; x-ray computed tomography | English | 2022 | 2022-05-20 | 10.1038/s41598-022-11972-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Deep convolutional neural network-based skeletal classification of cephalometric image compared with automated-tracing software | This study aimed to investigate deep convolutional neural network- (DCNN-) based artificial intelligence (AI) model using cephalometric images for the classification of sagittal skeletal relationships and compare the performance of the newly developed DCNN-based AI model with that of the automated-tracing AI software. A total of 1574 cephalometric images were included and classified based on the A-point-Nasion- (N-) point-B-point (ANB) angle (Class I being 0-4 degrees, Class II > 4 degrees, and Class III < 0 degrees). The DCNN-based AI model was developed using training (1334 images) and validation (120 images) sets with a standard classification label for the individual images. A test set of 120 images was used to compare the AI models. The agreement of the DCNN-based AI model or the automated-tracing AI software with a standard classification label was measured using Cohen's kappa coefficient (0.913 for the DCNN-based AI model; 0.775 for the automated-tracing AI software). In terms of their performances, the micro-average values of the DCNN-based AI model (sensitivity, 0.94; specificity, 0.97; precision, 0.94; accuracy, 0.96) were higher than those of the automated-tracing AI software (sensitivity, 0.85; specificity, 0.93; precision, 0.85; accuracy, 0.90). With regard to the sagittal skeletal classification using cephalometric images, the DCNN-based AI model outperformed the automated-tracing AI software. | Kim, Ho-Jin; Kim, Kyoung Dong; Kim, Do-Hoon | Kyungpook Natl Univ, Sch Dent, Dept Orthodont, 2175 Dalgubul Daero, Daegu 41940, South Korea; Kyungpook Natl Univ, Coll IT Engn, Sch Elect & Elect Engn, Daegu, South Korea; Kyungpook Natl Univ, Med Big Data Res Ctr, Daegu, South Korea | Kim, Hong/AAR-4892-2020 | 57200084686; 57789439700; 55624468392 | hojinkim@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.71 | 2025-06-25 | 14 | 10 | DIAGNOSIS | Artificial Intelligence; Neural Networks, Computer; Software; artificial intelligence; software | English | 2022 | 2022-07-08 | 10.1038/s41598-022-15856-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Deep neural network-based structural health monitoring technique for real-time crack detection and localization using strain gauge sensors | Structural health monitoring (SHM) techniques often require a large number of sensors to evaluate and monitor the structural health. In this paper, we propose a deep neural network (DNN)-based SHM method for accurate crack detection and localization in real time using a small number of strain gauge sensors and confirm its feasibility based on experimental data. The proposed method combines a DNN model with principal component analysis (PCA) to predict the strain field based on the local strains measured by strain gauge sensors located rather sparsely. We demonstrate the potential of the proposed technique via a cyclic 4-point bending test performed on a composite material specimen without cracks and seven specimens with different lengths of cracks. A dataset containing local strains measured with 12 strain gauge sensors and strain field measured with a digital image correlation (DIC) device was prepared. The strain field dataset from DIC is converted to a smaller dimension latent space with a few eigen basis via PCA, and a DNN model is trained to predict principal component values of each image with 12 strain gauge sensor measurements as input. The proposed method turns out to accurately predict the strain field for all specimens considered in the study. | Yoon, Jiyoung; Lee, Junhyeong; Kim, Giyoung; Ryu, Seunghwa; Park, Jinhyoung | Korea Inst Ind Technol, Adv Mechatron R&D Grp, Daegu 42994, South Korea; Korea Adv Inst Sci & Technol, Dept Mech Engn, Daejeon 34141, South Korea; Kyungpook Natl Univ, Dept Mech Engn, Daegu 41566, South Korea; Korea Univ Technol & Educ, Sch Mechatron Engn, Cheonan 31253, South Korea | Ryu, Seunghwa/B-9155-2011; Kim, Kyoung-Sook/A-7768-2017 | 57218699427; 57203144888; 57979801000; 55555333000; 57225161884 | jhpark98@koreatech.ac.kr;ryush@kaist.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 2.77 | 2025-06-25 | 33 | 41 | IDENTIFICATION | Dacarbazine; Neural Networks, Computer; Principal Component Analysis; dacarbazine; principal component analysis | English | 2022 | 2022-11-23 | 10.1038/s41598-022-24269-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Determination of sequence and absolute configuration of peptide amino acids by HPLC-MS/CD-based detection of liberated N-terminus phenylthiohydantoin amino acids | We report a method for the simultaneous determination of the sequence and absolute configuration of peptide amino acids using a combination of Edman degradation and HPLC-MS/CD. Phenylthiohydantoin (PTH) derivatives of 20 pairs of standard d- and l-amino acids were synthesized by the Edman reaction. The CD spectra of the derivatives revealed that each pair of the PTH derivatives exhibited the absorption with opposite signs at around 270 nm. These standard PTH derivatives showed well-resolved resolution without interference from byproducts in the ion chromatogram and clear positive/negative CD absorptions when subjected on a reversed phase HPLC-MS system coupled with a CD-2095 HPLC detector. This method was applied for the detection of a synthetic pentapeptide and a natural depsipeptide (halicylindramide C). The sequence and configuration of the pentapeptide and up to eight residues of halicylindramide C were successfully analyzed by this method. The amino acid configuration of the pentapeptide was also determined successfully by subjecting its acid hydrolysates to the Edman reaction followed by HPLC-MS/CD. | Hahn, Dongyup; Wang, Weihong; Choi, Hyukjae; Kang, Heonjoong | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Integrat Biotechnol, Daegu 41566, South Korea; Seoul Natl Univ, Sch Earth & Environm Sci, Lab Marine Drugs, NS-80,1 Gwanak Ro, Seoul 08826, South Korea; Seoul Natl Univ, Res Inst Oceanog, Seoul 08826, South Korea; Yeungnam Univ, Coll Pharm, 280 Daehak Ro, Gyongsan 38541, Gyeongsangbuk D, South Korea; Seoul Natl Univ, Interdisciplinary Grad Program Genet Engn, NS-80, Seoul 08826, South Korea | 36554163400; 55355129000; 7404339587; 7404070913 | h5choi@yu.ac.kr;hjkang@snu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.21 | 2025-06-25 | 3 | 3 | INDUCED CIRCULAR-DICHROISM; LIQUID-CHROMATOGRAPHY; CYTOTOXIC DEPSIPEPTIDES; PHENYL ISOTHIOCYANATE; AXIAL CHIRALITY; BIPHENYL CORE; ALPHA-AMINO; D-ASPARTATE; REAGENT; RESIDUE | Amines; Amino Acids; Chromatography, High Pressure Liquid; Mass Spectrometry; Peptides; Phenylthiohydantoin; amine; amino acid; peptide; phenylthiohydantoin; chemistry; high performance liquid chromatography; mass spectrometry; procedures | English | 2022 | 2022-06-18 | 10.1038/s41598-022-14205-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Development of mixed starter culture for the fermentation of Ethiopian honey wine, Tej | Ethiopian honey wine is one of the country's most popular spontaneously fermented traditional alcoholic beverages. However, the final product of this natural fermentation system is frequently of poor and inconsistent quality. Furthermore, it makes the process difficult to predict, control, and correct. Thus, the main aim of this study was to develop a direct fermentation system for Ethiopian honey wine, Tej. After isolating fermentative microbial strains from Tej samples, they were subjected to intensive screening to fit to its purpose. Later, phenotypic and genotypic characterization, and inoculation of isolates to honey-must were performed sequentially. Finally, microbial interaction and physicochemical analysis, including volatile compounds profiling, were done for the inoculated samples. The identified isolates were strains of Saccharomycetaceae and Lactobacillaceae families. These strains showed a good ability to tolerate osmotic stress and a lower pH environment. Tej sample produced by mixed culture inoculation of Saccharomyces and Lactobacillus species showed similar physicochemical, volatile compounds, and sensory attributes values with that of the control sample. Thus, a mixture of Saccharomyces and Lactobacillus strains could be used as a starter culture to produce Ethiopian honey, Tej, without scarifying of its major quality attributes. | Fentie, Eskindir Getachew; Jeong, Minsoo; Emire, Shimelis Admassu; Demsash, Hundessa Dessalegn; Kim, Min-Chul; Lim, Kyeongmo; Shin, Jae-Ho | Addis Ababa Sci & Technol Univ, Coll Biol & Chem Engn, Addis Ababa 16417, Ethiopia; Addis Ababa Univ, Addis Ababa Inst Technol, Sch Chem & Bioengn, King George VI St,POB 385, Addis Ababa 16417, Ethiopia; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea | Fentie, Eskindir/LIG-6089-2024; shin, Jaeho/K-6792-2013 | 57245844200; 57292954900; 36189913000; 57192308986; 57203466596; 57805008000; 57224125922 | jhshin@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.5 | 2025-06-25 | 4 | 7 | GAS CHROMATOGRAPHY/MASS SPECTROMETRY; SOLID-PHASE MICROEXTRACTION; SACCHAROMYCES-CEREVISIAE; VOLATILE COMPOSITION; RAPD-PCR; YEAST; LACTOBACILLI; DIVERSITY; BACTERIA; GROWTH | Ethiopia; Fermentation; Honey; Humans; Lactobacillus; Saccharomyces; Wine; Ethiopia; fermentation; honey; human; Lactobacillus; Saccharomyces; wine | English | 2022 | 2022-08-04 | 10.1038/s41598-022-17594-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Article | Diagnostic and therapeutic characteristics of diabetes mellitus and risk of out-of-hospital cardiac arrest | This study aimed to evaluate the risks of diabetes mellitus (DM) on out-of-hospital cardiac arrest (OHCA) and to investigate whether the risks of DM on OHCA varied according to the diagnostic and therapeutic characteristics of diabetes. We conducted a multicenter prospective case–control study in 17 University hospitals in Korea from September 2017 to December 2020. Cases were EMS-treated OHCA patients aged 20 to 79 with a presumed cardiac etiology. Community-based controls were recruited at a 1:2 ratio after matching for age, sex, and urbanization level of residence. A structured questionnaire and laboratory findings were collected from cases and controls. Multivariable conditional logistic regression analyses were conducted to estimate the risk of DM on OHCA by characteristics. A total of 772 OHCA cases and 1544 community-based controls were analyzed. A total of 242 (31.3%) OHCAs and 292 (18.9%) controls were previously diagnosed with DM. The proportions of type I DM (10.7% vs. 2.1%) and insulin therapy (15.3% vs. 6.5%) were higher in OHCAs with DM than in controls with DM. The duration of DM was longer in OHCAs than in controls (median 12 vs. 7 years). DM was associated with an increased risk of OHCA (aOR (95% CI), 2.13 (1.64–2.75)). Compared to the no diabetes group, the risks of OHCA increased in the diabetes patients with type I DM (5.26 (1.72–16.08)) and type II DM group (1.63 (1.18–2.27)), a long duration of DM prevalence (1.04 (1.02–1.06) per 1-year prevalence duration), and a high HbA1c level (1.38 (1.19–1.60) per 1% increase). By treatment modality, the aOR (95% CI) was lowest in the oral hypoglycemic agent (1.47 (1.08–2.01)) and highest in the insulin (6.63 (3.04–14.44)) groups. DM was associated with an increased risk of OHCA, and the risk magnitudes varied according to the diagnostic and therapeutic characteristics. © 2022, The Author(s). | Park, Jeong Ho; Ro, Young Sun; Shin, Sang Do; Cha, Kyoung-Chul; Song, Kyoung Jun; Hwang, Sung Oh; Lee, Mi Jin; Park, Jong-Hak; Kim, Su Jin; Oh, Sung Bum; Shin, Jonghwan; Park, Seung Min; Sim, Min Seob; Kim, Won Young; Park, In-Cheol; Ryu, Hyun Ho; You, Yeonho; Kim, Sang-Chul; Park, Ju Ok | Department of Emergency Medicine, Seoul National University College of Medicine and Seoul National University Hospital, Seoul, South Korea, Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, 101 Daehak-Ro, Jongno-Gu, Seoul, 03080, South Korea; Department of Emergency Medicine, Seoul National University College of Medicine and Seoul National University Hospital, Seoul, South Korea, Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, 101 Daehak-Ro, Jongno-Gu, Seoul, 03080, South Korea; Department of Emergency Medicine, Seoul National University College of Medicine and Seoul National University Hospital, Seoul, South Korea, Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, 101 Daehak-Ro, Jongno-Gu, Seoul, 03080, South Korea, Seoul National University Hospital, Seoul, South Korea; Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea; Laboratory of Emergency Medical Services, Seoul National University Hospital Biomedical Research Institute, 101 Daehak-Ro, Jongno-Gu, Seoul, 03080, South Korea, Department of Emergency Medicine, Seoul National University Boramae Medical Center, Seoul, South Korea; Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea, Yonsei University Wonju Severance Christian Hospital, Wonju, South Korea; Kyungpook National University Hosptial, Daegu, South Korea; Korea University Ansan Hospital, Ansan, South Korea; Korea University Anam Hospital, Seoul, South Korea; Dankook University Hospital, Yongin, South Korea; Seoul National University Boramae Medical Center, Seoul, South Korea; Seoul National University Bundang Hospital, Seongnam, South Korea; Sungkyunkwan University Samsung Medical Center, Seoul, South Korea; Ulsan University Asan Medical Center, Seoul, South Korea; Yonsei University Severance Hospital, Seoul, South Korea; Chonnam National University Hospital, Gwangju, South Korea; Chungnam National University Hospital, Daejeon, South Korea; Chungbuk National University Hospital, Cheongju, South Korea; Hallym University Dongtan Sacred Heart Hospital, Chuncheon, South Korea | 57222635486; 37665990400; 57049712400; 39860962000; 57037616400; 57202063517; 55507282600; 57196407523; 57196044127; 57428640900; 57049712300; 54411205900; 26645185500; 55661654200; 56573250000; 26325849500; 35077217100; 7601581324; 57196406548 | Ro.youngsun@gmail.com; | Scientific Reports | SCI REP-UK | 2045-2322 | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.28 | 2025-06-25 | 4 | Adult; Aged; Case-Control Studies; Diabetes Complications; Diabetes Mellitus; Female; Hospitals, University; Humans; Male; Middle Aged; Odds Ratio; Out-of-Hospital Cardiac Arrest; Prospective Studies; Republic of Korea; Risk Factors; adult; aged; case control study; clinical trial; diabetes mellitus; diabetic complication; female; human; male; middle aged; multicenter study; odds ratio; out of hospital cardiac arrest; prospective study; risk factor; South Korea; university hospital | English | Final | 2022 | 10.1038/s41598-022-05390-w | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | Article | Dominant predictors of early post-transplant outcomes based on the Korean Organ Transplantation Registry (KOTRY) | Data for Asian kidney transplants are very limited. We investigated the relative importance of prognostic markers in Asian kidney transplants by using Korean Organ Transplantation Registry (KOTRY) cohort. Prediction models were developed by data-driven variable selection approach. The relative importance of the selected predictors was measured by dominance analysis. A total of 4854 kidney transplant donor-recipient pairs were analyzed. Overall patient survival rates were 99.8%, 98.8%, and 91.8% at 1, 3, and 5 years, respectively. Death-censored graft survival rates were 98.4%, 97.0%, and 95.8% at 1, 3, and 5 years. Biopsy-proven acute rejection free survival rates were 90.1%, 87.4%, and 87.03% at 1, 3, and 5 years. The top 3 dominant predictors for recipient mortality within 1 year were recipient cardiovascular disease history, deceased donor, and recipient age. The dominant predictors for death-censored graft loss within 1 year were acute rejection, deceased donor, and desensitization. The dominant predictors to acute rejection within 1 year were donor age, HLA mismatched numbers, and desensitization. We presented clinical characteristics of patients enrolled in KOTRY during the last 5 years and investigated dominant predictors for early post-transplant outcomes, which would be useful for clinical decision-making based on quantitative measures. © 2022, The Author(s). | Jeong, Jong Cheol; Koo, Tai Yeon; Ro, Han; Lee, Dong Ryeol; Lee, Dong Won; Kim, Jayoun; Chae, Dong-Wan; Kim, Young Hoon; Huh, Kyu Ha; Park, Jae Berm; Kim, Yeong Hoon; Han, Seungyeup; Choi, Soo Jin Na; Lee, Sik; Min, Sang-Il; Ha, Jongwon; Kim, Myoung Soo; Ahn, Curie; Yang, Jaeseok; Ahn, Curie; Kim, Myoung Soo; Kong, Jin Min; Kwon, Oh Jung; Kim, Deok Gie; Jung, Cheol Woong; Kim, Joong Kyung; Kim, Chan-Duck; Min, Ji Won; Park, Sung Kwang; Park, Yeon Ho; Park, Jae Berm; Park, Jung Hwan; Song, Sang Heon; Ban, Tae Hyun; Song, Seung Hwan; Shin, Ho Sik; Yang, Chul Woo; Lee, Sam Yeol; Lee, Sang-Ho; Lee, Su Hyung; Lee, Yu Ho; Lee, Jung Pyo; Lee, Jeong-Hoon; Jeon, Jin Seok; Jun, Heungman; Jeong, Kyunghwan; Chung, Ku Yong; Chae, Dong-Wan; Ki, Ju Man; Shin, Sung; Oh, Jieun | Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea; Department of Nephrology, Seongnam Citizens Medical Center, Seongnam, South Korea; Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Inchon, South Korea; Division of Nephrology, Medicine, Maryknoll Medical Center, Busan, South Korea, Department of Internal Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea College of Medicine, Seoul, South Korea; Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, Busan, South Korea, Department of Nephrology, Chungnam National University Hospital, Daejeon, South Korea; Medical Research Collaborating Center, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea; Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea; Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, South Korea; Department of Internal Medicine, Keimyung University School of Medicine, Daegu, South Korea; Department of Surgery, Chonnam National University Medical School, Gwangju, South Korea; Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju, South Korea; Department of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea; Department of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea, Transplantation Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea; Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, Korean Organ Transplantation Registry Foundation, 3rd Floor, Myeongryun-gil 22, Jongno-gu, Seoul, South Korea; Laboratory of Transplantation Immunology, Division of Nephrology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Room 336, 3rd Floor, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, Korean Organ Transplantation Registry Foundation, 3rd Floor, Myeongryun-gil 22, Jongno-gu, Seoul, South Korea; Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea; Department of Nephrology, BHS Hanseo Hospital, Busan, South Korea; Department of Surgery, College of Medicine, Han Yang University, Seoul, South Korea; Department of Surgery, Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, Wonju, South Korea; Department of Surgery, Korea University Anam Hospital, Seoul, South Korea; Department of Internal Medicine, Bongseng Memorial Hospital, Busan, South Korea; Department of Internal Medicine, School of Medicine, Kyungpook National University Hospital, Daegu, South Korea; Division of Nephrology, Department of Internal Medicine, Bucheon St. Mary’s Hospital, Bucheon-si, South Korea; Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju, South Korea; Department of Surgery, Gil Medical Center, Gachon University College of Medicine, Incheon, South Korea; Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Nephrology, Konkuk University School of Medicine, Seoul, South Korea; Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, Busan, South Korea, Department of Nephrology, Yeungnam University Hospital, Daegu, South Korea; Division of Nephrology, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, Seoul, South Korea; Department of Surgery, Ewha Womans University Seoul Hospital, Seoul, South Korea; Division of Nephrology, Department of Internal Medicine, Kosin University College of Medicine, Busan, South Korea; Division of Nephrology, Department of Internal Medicine, Seoul St. Mary’s Hospital, Seoul, South Korea; Department of Surgery, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, South Korea; Department of Nephrology, Kyung Hee University Hospital at Gangdong, Seoul, South Korea; Department of Surgery, Ajou University School of Medicine, Suwon, South Korea; Division of Nephrology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, South Korea; Department of Nephrology, SMG-SNU Boramae Medical Center, Seoul, South Korea; Department of Surgery, Myongji Hospital, Goyang, South Korea; Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, South Korea; Department of Surgery, Inje University Ilsan Paik Hospital, Goyang, South Korea; Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, South Korea; Department of Surgery, Ewha Womans University Mokdong Hospital, Seoul, South Korea; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea, Department of Surgery, Ulsan University Hospital, Ulsan, South Korea; Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea; Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea; Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea | 37761626800; 25646406800; 26538034700; 57218150487; 57199467944; 56272817800; 23471686900; 57281310600; 35183155900; 13605451500; 7410196419; 24281360600; 35784016900; 57192521521; 57225298942; 16240657000; 35268871600; 57265492500; 57212326527; 7201986669; 57991986800; 7202290990; 57252511100; 57198637675; 7402016375; 56508055400; 8558530700; 56212607100; 57203275923; 57189388760; 57902887600; 56682283600; 36162581500; 56119751700; 57226657760; 57216238599; 7407743404; 57197749641; 55890136000; 57307240100; 56344334200; 56028990400; 57218629097; 36120293400; 55508260600; 8443579300; 24773386100; 57964963700; 57220162686; 56160996300; 8409118400 | jcyjs@yuhs.ac; | Scientific Reports | SCI REP-UK | 2045-2322 | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.28 | 2025-06-25 | 4 | Graft Rejection; Graft Survival; Humans; Kidney Transplantation; Registries; Republic of Korea; Tissue Donors; Treatment Outcome; donor; epidemiology; graft rejection; graft survival; human; kidney transplantation; register; South Korea; treatment outcome | English | Final | 2022 | 10.1038/s41598-022-12302-5 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Early neoproterozoic supracrustal successions in the central Korean Peninsula: Implications for the paleotectonic history of East Asia | The Early Neoproterozoic supracrustal metasedimentary succession from the Paju-Yangju-Dongducheon area in the central Korean Peninsula is distributed along the northwestern margin of the basement gneisses in the Middle Paleoproterozoic Gyeonggi Massif. The metasedimentary succession includes quartzite, quartz-mica schist, mica schist, calc schist, marble, and calc-silicate, showing alternating layering and large-scale isoclinal folds with Middle Paleoproterozoic gneisses. The basement gneisses yield zircon LA-MC-ICPMS U-Pb ages of 1.87-1.86 Ga. Detrital zircon U-Pb ages of eight quartzites, seven quartz-mica schists and four calc schists suggest the following features. (1) Early Neoproterozoic (ca. 0.92 Ga) sedimentation, (2) prominent age peaks in the Late Paleo-proterozoic to Mesoproterozoic range, (3) sandy proximal and muddy to calcic distal provenances, and (4) age population under extensional and trailing edge settings. The detritus of the quartzites were mainly derived from the peripheral Middle Paleoproterozoic basement. In contrast, quartz-mica schists and calc schists show detritus derived from distal Late Paleoproterozoic to Mesoproterozoic clastic sources in the southeastern North China Craton and central Korean Peninsula where magmatic rocks related to the extensional tectonics associated with the disruption of the Columbia supercontinent occur. The detrital zircon records and litho-tectonic features indicate that the Early Neoproterozoic rocks in the Paju-Yangju-Dongducheon area, as well as the central Korean Peninsula, show similarities with the southeastern North China Craton. We therefore interpret that the Early Neoproterozoic supracrustal metasedimentary successions were deposited in marginal shallow marine to fluvial environments from the marginal part of the linked central Korean Peninsula and the southeastern North China Craton which were located at the southwestern margin of western part of the Columbia supercontinent during the Early Neoproterozoic (ca. 0.92 Ga). However, metamorphic overgrowths on zircons and large-scale isoclinal folding in the alternation of the Early Neoproterozoic metasedimentary and the Middle Paleoproterozoic rocks in the Paju-Yangju-Dongducheon area are related to Late Permian to Triassic compressional collision tectonics in the central Korean Peninsula after the Early Neoproterozoic sedimentation. | Kim, Sung Won; Lee, Bo Young; Ko, Kyoungtae; Santosh, M.; Kee, Weon Seo; Park, Seung-Ik; Lee, Seung Hwan; Lee, Byung Choon; Koh, Hee Jae; Jeong, Youn-Joong | Korea Inst Geosci & Mineral Resources, Geol Div, Daejeon 34132, South Korea; China Univ Geosci, Sch Earth Sci & Resources, 29 Xueyuan Rd, Beijing 100083, Peoples R China; Univ Adelaide, Dept Earth Sci, Adelaide, SA 5005, Australia; Northwest Univ, Dept Geol, State Key Lab Continental Dynam, Northern Taibai Str 229, Xian 710069, Peoples R China; Kyungpook Natl Univ, Dept Geol, Daegu 41566, South Korea; Korea Basic Sci Inst, Div Earth & Environm Sci, Chungbuk 28119, South Korea | Kim, Sung/U-2460-2017; Santosh, M/B-2563-2012 | 57205215568; 57912075900; 56652511400; 57531732700; 12791811800; 55832472000; 57911879500; 57911487900; 57911282600; 49161097900 | wskee@kigam.re.kr; | PRECAMBRIAN RESEARCH | PRECAMBRIAN RES | 0301-9268 | 1872-7433 | 381 | SCIE | GEOSCIENCES, MULTIDISCIPLINARY | 2022 | 3.8 | 29.5 | 0.61 | 2025-06-25 | 6 | 5 | Early Neoproterozoic sedimentation; Paju-Yangju-Dongducheon area; Gyeonggi Massif; Central Korean Peninsula; Paleotectonic evolution; Detrital zircon record | NORTH CHINA CRATON; WESTERN GYEONGGI MASSIF; SOUTH-KOREA; GEOLOGICAL SIGNIFICANCE; PRECAMBRIAN BASEMENT; PLUTONIC ROCKS; YANGTZE BLOCK; MAGMATISM; GEOCHEMISTRY; EVOLUTION | Central Korean Peninsula; Detrital zircon record; Early Neoproterozoic sedimentation; Gyeonggi Massif; Paju–Yangju–Dongducheon area; Paleotectonic evolution | Gyeonggi Massif; South Korea; collision zone; folding; gneiss; Proterozoic; quartzite; schist; sedimentation; supracrustal rock; tectonic evolution; tectonics; uranium-lead dating; zircon | English | 2022 | 2022-10 | 10.1016/j.precamres.2022.106849 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effect of pretransplant dialysis vintage on clinical outcomes in deceased donor kidney transplant | The waiting time for deceased donor kidney transplants (DDKT) is increasing. We evaluated DDKT prognosis according to the pretransplant dialysis vintage. A total of 4117 first-time kidney transplant recipients were enrolled from a prospective nationwide cohort in Korea. DDKT recipients were divided into tertiles according to pretransplant dialysis duration. Graft failure, mortality, and composite were compared between DDKT and living donor kidney transplant (LDKT) recipients. Pretransplant dialysis vintage was longer annually in DDKT recipients. In the subdistribution of the hazard model for the competing risk, the first tertile did not show an increased risk of graft failure compared with LDKT recipients; however, the second and third tertile groups had an increased risk of graft failure compared to LDKT recipients (adjusted hazard ratio [aHR] 3.59; 95% confidence interval [CI] 1.69-7.63; P < 0.001; aHR 2.37; 95% CI 1.06-5.33; P = 0.037). All DDKT groups showed a significantly higher risk of patient death than LDKT, with the highest risk in the third tertile group (aHR 11.12; 95% CI 4.94-25.00; P < 0.001). A longer pretransplant dialysis period was associated with a higher risk of the composite of patient death and graft failure in DDKT recipients. DDKT after a short period of dialysis had non-inferior results on graft survival compared with LDKT. | Lim, Jeong-Hoon; Jeon, Yena; Kim, Deok Gie; Kim, Yeong Hoon; Kim, Joong Kyung; Yang, Jaeseok; Kim, Myoung Soo; Jung, Hee-Yeon; Choi, Ji-Young; Park, Sun-Hee; Kim, Chan-Duck; Kim, Yong-Lim; Cho, Jang-Hee | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Yonsei Univ, Wonju Severance Christian Hosp, Dept Surg, Wonju Coll Med, Wonju, South Korea; Inje Univ, Dept Internal Med, Busan Paik Hosp, Busan, South Korea; Bongseng Mem Hosp, Dept Internal Med, Busan, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Yonsei Univ, Dept Surg, Coll Med, Seoul, South Korea | Kim, Seung-Ki/J-2742-2012; Kim, Tae-Hee/AAN-9079-2021; Kim, Min-Hyuk/ITV-2946-2023; Cho, Jang-hee/ABD-3534-2020; Lim, Jeong-Hoon/ABE-6003-2020; Yang, Jae/LUW-8250-2024; Kim, Yong-Lim/AGK-3172-2022; Jung, Hee-Yeon/AFB-8578-2022; Park, Sun-Hee/LMN-0033-2024 | 55360244300; 57209909350; 57198637675; 7410196419; 56508055400; 57212326527; 35268871600; 57196396467; 7501393222; 7501831741; 8558530700; 55633533600; 7403536291; 57991986800; 7202290990; 57252511100; 7402016375; 59216189400; 56212607100; 57192521521; 57189388760; 13605451500; 56682283600; 54955660800; 56119751700; 36162581500; 57226657760; 57216238599; 7407743404; 57737628900; 7501514537; 55890136000; 57307240100; 56344334200; 56028990400; 57218629097; 36120293400; 55508260600; 8443579300; 24773386100; 57201264463; 23471686900; 35784016900; 56160996300; 24281360600; 35183155900 | jh-cho@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.57 | 2025-06-25 | 7 | 8 | UNITED-STATES; WAITING TIME; MORTALITY; SURVIVAL; ASSOCIATION; DURATION; RISK | Graft Survival; Humans; Kidney Transplantation; Living Donors; Prospective Studies; Renal Dialysis; Retrospective Studies; Treatment Outcome; adverse event; graft survival; hemodialysis; human; kidney transplantation; living donor; prospective study; retrospective study; treatment outcome | English | 2022 | 2022-10-21 | 10.1038/s41598-022-20003-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Effect of teriparatide on drug treatment of tuberculous spondylitis: an experimental study | Tuberculous spondylitis often develops catastrophic bone destruction with uncontrolled inflammation. Because anti-tuberculous drugs do not have a role in bone formation, a combination drug therapy with a bone anabolic agent could help in fracture prevention and promote bone reconstruction. This study aimed to investigate the influence of teriparatide on the effect of anti-tuberculous drugs in tuberculous spondylitis treatment. We used the virulent Mycobacterium tuberculosis (Mtb) H37Rv strain. First, we investigated the interaction between teriparatide and anti-tuberculosis drugs (isoniazid and rifampin) by measuring the minimal inhibitory concentration (MIC) against H37Rv. Second, we evaluated the therapeutic effect of anti-tuberculosis drugs and teriparatide on our previously developed in vitro tuberculous spondylitis model of an Mtb-infected MG-63 osteoblastic cell line using acid-fast bacilli staining and colony-forming unit counts. Selected chemokines (interleukin [IL]-8, interferon gamma-induced protein 10 kDa [IP-10], monocyte chemoattractant protein [MCP]-1, and regulated upon activation, normal T cell expressed and presumably secreted [RANTES]) and osteoblast proliferation (alkaline phosphatase [ALP] and alizarin red S [ARS] staining) were measured. Teriparatide did not affect the MIC of isoniazid and rifampin. In the Mtb-infected MG-63 spondylitis model, isoniazid and rifampin treatment significantly reduced Mtb growth, and cotreatment with teriparatide did not change the anti-tuberculosis effect of isoniazid (INH) and rifampin (RFP). IP-10 and RANTES levels were significantly increased by Mtb infection, whereas teriparatide did not affect all chemokine levels as inflammatory markers. ALP and ARS staining indicated that teriparatide promoted osteoblastic function even with Mtb infection. Cotreatment with teriparatide and the anti-tuberculosis drugs activated bone formation (ALP-positive area increased by 705%, P=0.0031). Teriparatide was effective against Mtb-infected MG63 cells without the anti-tuberculosis drugs (ARS-positive area increased by 326%, P=0.0037). Teriparatide had no effect on the efficacy of anti-tuberculosis drugs and no adverse effect on the activity of Mtb infection in osteoblasts. Furthermore, regulation of representative osteoblastic inflammatory chemokines was not changed by teriparatide treatment. In the in vitro Mtb-infected MG-63 cell model of tuberculous spondylitis, cotreatment with the anti-tuberculosis drugs and teriparatide increased osteoblastic function. | Lee, Subum; Seo, Ye-Jin; Choi, Je-Yong; Che, Xiangguo; Kim, Hyun-Ju; Eum, Seok-Yong; Hong, Min-Sun; Lee, Sun-Kyoung; Cho, Dae-Chul | Korea Univ, Coll Med, Dept Neurosurg, Anam Hosp, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Neurosurg, 130 Dongduk Ro, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu, South Korea; Int TB Res Ctr, Div Immunopathol & Cellular Immunol, Changwon Si, Gyeongsangnam D, South Korea | Choi, Je-Yong/AAR-7334-2021; Lee, Subum/AFQ-2764-2022 | 57193631061; 57200397258; 7501391068; 54792660600; 57208650339; 6602611934; 35558645400; 56081936800; 55859543400 | dccho@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.21 | 2025-06-25 | 2 | 3 | MONOCYTE CHEMOATTRACTANT PROTEIN-1; PARATHYROID-HORMONE; IFN-GAMMA; INFLAMMATORY CYTOKINES; CHEMOTACTIC PROTEIN-1; CHEMOKINE RECEPTORS; HUMAN OSTEOCLASTS; BONE METASTASIS; TNF-ALPHA; CELLS | Antitubercular Agents; Chemokine CXCL10; Humans; Isoniazid; Mycobacterium tuberculosis; Rifampin; Teriparatide; Tuberculosis, Spinal; gamma interferon inducible protein 10; isoniazid; parathyroid hormone[1-34]; rifampicin; tuberculostatic agent; human; Mycobacterium tuberculosis; tuberculous spondylitis | English | 2022 | 2022-12-15 | 10.1038/s41598-022-25174-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Enhancement of cerebrospinal fluid tracer movement by the application of pulsed transcranial focused ultrasound | Efficient transport of solutes in the cerebrospinal fluid (CSF) plays a critical role in their clearance from the brain. Convective bulk flow of solutes in the CSF in the perivascular space (PVS) is considered one of the important mechanisms behind solute movement in the brain, before their ultimate drainage to the systemic lymphatic system. Acoustic pressure waves can impose radiation force on a medium in its path, inducing localized and directional fluidic flow, known as acoustic streaming. We transcranially applied low-intensity focused ultrasound (FUS) to rats that received an intracisternal injection of fluorescent CSF tracers (dextran and ovalbumin, having two different molecular weights-M-w). The sonication pulsing parameter was determined on the set that propelled the aqueous solution of toluidine blue O dye into a porous media (melamine foam) at the highest level of infiltration. Fluorescence imaging of the brain showed that application of FUS increased the uptake of ovalbumin at the sonicated plane, particularly around the ventricles, whereas the uptake of high-M-w dextran was unaffected. Numerical simulation showed that the effects of sonication were non-thermal. Sonication did not alter the animals' behavior or disrupt the blood-brain barrier (BBB) while yielding normal brain histology. The results suggest that FUS may serve as a new non-invasive means to promote interstitial CSF solute transport in a region-specific manner without disrupting the BBB, providing potential for enhanced clearance of waste products from the brain. | Yoo, Seung-Schik; Kim, Hyun-Chul; Kim, Jaeho; Kim, Evgenii; Kowsari, Kavin; Van Reet, Jared; Yoon, Kyungho | Harvard Med Sch, Brigham & Womens Hosp, Dept Radiol, 75 Francis St, Boston, MA 02115 USA; Kyungpook Natl Univ, Dept Artificial Intelligence, Daegu, South Korea; Hallym Univ Coll Med, Dongtan Sacred Heart Hosp, Dept Neurol, Hwaseong Si, Gyeonggi Do, South Korea; MIT, Dept Mech Engn, Boston, MA USA; Yonsei Univ, Sch Math & Comp Computat Sci & Engn, Seoul, South Korea | ; Yoon, Kyungho/JXN-7595-2024; Kim, Junpyo/HGD-2747-2022; Kim, Leehyung/AAN-6760-2020 | 7401970708; 57194876917; 57203325414; 59845978800; 55943178100; 57823770600; 57208559577 | yoo@bwh.harvard.edu; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 1.21 | 2025-06-25 | 19 | 17 | AMYLOID-BETA; BRAIN; DIFFUSION; DISRUPTION; IMPAIRMENT; TRANSPORT; PERFUSION; PRESSURE; DELIVERY; PATHWAY | Animals; Blood-Brain Barrier; Brain; Dextrans; Ovalbumin; Rats; Rats, Sprague-Dawley; dextran; ovalbumin; animal; blood brain barrier; brain; diagnostic imaging; rat; Sprague Dawley rat | English | 2022 | 2022-07-28 | 10.1038/s41598-022-17314-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Estimation of best corrected visual acuity based on deep neural network | In this study, we investigated a convolutional neural network (CNN)-based framework for the estimation of the best-corrected visual acuity (BCVA) from fundus images. First, we collected 53,318 fundus photographs from the Gyeongsang National University Changwon Hospital, where each fundus photograph is categorized into 11 levels by retrospective medical chart review. Then, we designed 4 BCVA estimation schemes using transfer learning with pre-trained ResNet-18 and EfficientNet-B0 models where both regression and classification-based prediction are taken into account. According to the results of the study, the predicted BCVA by CNN-based schemes is close to the actual value such that 94.37% of prediction accuracy can be achieved when 3 levels of difference can be tolerated during prediction. The mean squared error and R-2 score were measured as 0.028 and 0.654, respectively. These results indicate that the BCVA can be predicted accurately for extreme cases, i.e., the level of BCVA is close to either 0.0 or 1.0. Moreover, using the Guided Grad-CAM, we confirmed that the macula and the blood vessel surrounding the macula are mainly utilized in the prediction of BCVA, which validates the rationality of the CNN-based BCVA estimation schemes since the same area is also exploited during the retrospective medical chart review. Finally, we applied the t-distributed stochastic neighbor embedding to examine the characteristics of CNN-based BCVA estimation schemes. The developed BCVA estimation schemes can be employed to obtain the objective measurement of BVCA as well as the medical screening of people with poor access to medical care through smartphone-based fundus imaging. | Lee, Woongsup; Kim, Jin Hyun; Lee, Seongjin; Kim, Kyonghoon; Kang, Tae Seen; Han, Yong Seop | Gyeongsang Natl Univ, Dept Informat & Commun Engn, Tongyeong, South Korea; Gyeongsang Natl Univ, Dept AI Convergence Engn, Jinju, South Korea; Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu, South Korea; Gyeongsang Natl Univ, Changwon Hosp, Dept Ophthalmol, 11 Samjeongja Ro, Chang Won 51472, South Korea; Gyeongsang Natl Univ, Coll Med, Inst Hlth Sci, Dept Ophthalmol, Jinju, South Korea | 24776183200; 56242902800; 24824950900; 15065463500; 57020662400; 55489221800 | jin.kim@gnu.ac.kr;medcabin@naver.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 12 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 4.6 | 29.5 | 0.28 | 2025-06-25 | 3 | 4 | Fundus Oculi; Humans; Macula Lutea; Neural Networks, Computer; Retrospective Studies; Visual Acuity; eye fundus; human; retina macula lutea; retrospective study; visual acuity | English | 2022 | 2022-10-24 | 10.1038/s41598-022-22586-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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