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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Review | Investigating the multifaceted role of nucleolin in cellular function and Cancer: Structure, Regulation, and therapeutic implications | Nucleolin (NCL), a highly conserved and multifunctional phosphoprotein, is primarily localized in the nucleolus and participates in various cellular compartments, including the nucleoplasm, cytoplasm, and plasma membrane. Initially discovered in the 1970 s, NCL is integral to ribosome biogenesis through its roles in ribosomal RNA transcription, processing, and assembly. Beyond ribosome synthesis, NCL plays critical roles in cellular processes such as DNA and RNA metabolism, chromatin remodeling, and cell cycle regulation, underscoring its essentiality for cell viability. Structurally, NCL comprises multiple functional domains, which facilitates interaction with various kinases and other proteins. NCL's extensive post-translational modifications influence its localization and function. Importantly, NCL has emerged as a key player in multiple pathologies, particularly cancer, where it contributes to tumor growth, metastasis, and drug resistance. On the cell surface, NCL acts as a co-receptor for growth factors and other ligands, facilitating oncogenic signaling. Additionally, its regulation of non-coding RNAs, stabilization of oncogenic mRNAs, and involvement in immune evasion highlight its potential as a therapeutic target. This review provides an unexplored in-depth overview of NCL's structure, functions, and modifications, with a focus on its role in cancer biology and its therapeutic implications. | Prakash, Kruthika; Satishkartik, Srisri; Ramalingam, Satish; Gangadaran, Prakash; Gnanavel, S.; Aruljothi, K. N. | SRM Inst Sci & Technol, Dept Genet Engn, Kattankulathur 603203, India; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, FOUR KNU Convergence Educ Program Biomed Sci Creat, Daegu 41944, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Daegu 41944, South Korea; SRM Inst Sci & Technol, Dept Biomed Engn, Biomat Lab, Chengalpattu 603203, Tamil Nadu, India | ArulJothi, KN/AFU-0629-2022 | 59733317200; 59732967600; 23987942300; 54393130400; 59908301900; 56705564100 | aruljotn@srmist.edu.in; | GENE | GENE | 0378-1119 | 1879-0038 | 957 | SCIE | GENETICS & HEREDITY | 2024 | 2.4 | 53.7 | 0 | 2025-05-07 | 0 | 0 | Nucleolin; Nucleolus; Ribosome biogenesis; Cancer; Metastasis; Therapeutic target | PRE-RIBOSOMAL-RNA; MITOSIS-SPECIFIC PHOSPHORYLATION; SURFACE-EXPRESSED NUCLEOLIN; MESSENGER-RNA; BINDING-PROTEIN; G-QUADRUPLEX; DNA-DAMAGE; CHROMOSOME PERIPHERY; N-GLYCOSYLATION; LUNG-CANCER | Cancer; Metastasis; Nucleolin; Nucleolus; Ribosome biogenesis; Therapeutic target | Animals; Humans; Neoplasms; Nucleolin; Phosphoproteins; Protein Processing, Post-Translational; RNA-Binding Proteins; messenger RNA; nucleolin; ribosome RNA; untranslated RNA; nucleolin; phosphoprotein; RNA binding protein; biogenesis; cell cycle regulation; cell function; cell membrane; cell surface; cell viability; chromatin assembly and disassembly; controlled study; cytoplasm; human; human cell; immune evasion; intracellular space; malignant neoplasm; metastasis; neoplastic cell transformation; nonhuman; nucleolus; pharmacology; protein processing; regulatory mechanism; review; ribosome; RNA metabolism; RNA transcription; signal transduction; animal; chemistry; genetics; metabolism; neoplasm; pathology | English | 2025 | 2025-07-15 | 10.1016/j.gene.2025.149479 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Review | Theranostic extracellular vesicles: Emerging frontiers in neuromuscular disease diagnosis and therapy | Extracellular vesicles are endocytic origin nano-sized particles secreted by diverse cell types. These vesicles exchange information that alters the biological response of recipient cells across distant compartments. Neuromuscular diseases are a broad range of acquired or inherited progressive condition that affects the neuron cells and voluntary muscle functioning. Due to mutations and environmental factors, the muscles and neuron cells degenerate and are unable to regenerate. This review focuses on the biological significance and theranostic roles of EVs in the neuromuscular junction and current insights into rare diseases. EV-mediated response in neuromuscular diseases is involved in the pathophysiological process that includes homeostasis, immune response, cell adhesion, crossing the blood–brain barrier, and neuromuscular junction communication. The surface proteins and receptors of EVs serve as diagnostic biomarkers in disease progression and retrogression. Investigating the functional significance of EVs communicated between the brain and muscle may unravel the disease phenotype. Moreover, the current studies on EV therapeutics show a promising therapeutic strategy for the identification of biomarkers in neuromuscular diseases. © 2025 Elsevier B.V. | Archana, Rajavel; Rajendran, Ramya Lakshmi; Gangadaran, Prakash; Raja, Natesan Sella | Membrane Protein Interaction Laboratory, Department of Genetic Engineering, School of Bioengineering, SRM Institute of Science & Technology, Kattankulathur 603203, Tamilnadu, India; BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Sciences, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea, Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea, Cardiovascular Research Institute, Kyungpook National University, Daegu, 41944, South Korea; Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea, Cardiovascular Research Institute, Kyungpook National University, Daegu, 41944, South Korea; Membrane Protein Interaction Laboratory, Department of Genetic Engineering, School of Bioengineering, SRM Institute of Science & Technology, Kattankulathur 603203, Tamilnadu, India | 59958071300; 57195318729; 54393130400; 24723259200 | prakashg@knu.ac.kr; rajan3@srmist.edu.in; | Gene | GENE | 0378-1119 | 1879-0038 | 964 | SCIE | GENETICS & HEREDITY | 2024 | 2.4 | 53.7 | 0 | Biomarkers; Blood–brain barrier; Extracellular vesicles; Neuromuscular diseases; Theranostics | biological marker; membrane protein; nanoparticle; blood brain barrier; cell adhesion; controlled study; diagnosis; exosome; homeostasis; human; immune response; neuromuscular disease; neuromuscular junction; nonhuman; personalized medicine; phenotype; review | English | Final | 2025 | 10.1016/j.gene.2025.149640 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Unsupervised domain adaptation by cross-domain consistency learning for CT body composition | Computed tomography (CT) scans of the abdomen have become the gold standard for assessing body composition (BC). Accurate estimation of skeletal muscle and adipose tissues from CT scan slices is crucial for diagnosis and prognosis. Much research in abdominal image analysis focuses on the third lumbar vertebra (L3) due to its stability and ease of labeling compared to other lumbar vertebrae. This study leverages labeled L3 slices (source domain) to predict unlabeled slices from thoracic T1 to sacrum S5 region (target domain). We proposed a Twin Encoder-Decoder Network (TED-Net) with distinct weight initialization employing Cross-domain Consistency Learning (CDCL) for joint training across the domains. This strategy extends the network's knowledge by enforcing consistency between predictions from two segmentation networks. The training objective includes supervised loss terms for the source domain and unsupervised loss terms for the target domain. This results in increases of 6.68%, 3.31%, and 4.40% in Precision, Dice Similarity Coefficient, and Intersection over Union, respectively, indicating significant improvement in performance on the target domain, suggesting that domain-invariant feature learning through cross-domain consistency learning enhances a network's adaptability over unlabeled domains. | Ali, Shahzad; Lee, Yu Rim; Park, Soo Young; Tak, Won Young; Jung, Soon Ki | Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea | Jung, Soon Ki/P-7687-2018; Ali, Shahzad/GPG-6925-2022 | 57709386500; 57194094753; 57191674344; 7004074582; 57226791905 | shahzadali@knu.ac.kr; skjung@knu.ac.kr; | MACHINE VISION AND APPLICATIONS | MACH VISION APPL | 0932-8092 | 1432-1769 | 36 | 1 | SCIE | COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;COMPUTER SCIENCE, CYBERNETICS;ENGINEERING, ELECTRICAL & ELECTRONIC | 2024 | 2.3 | 53.7 | 0 | 2025-05-07 | 0 | 0 | Body composition; Unsupervised domain adaptation; CT segmentation; Skeletal muscle; Adipose tissues | ADIPOSE-TISSUE; SARCOPENIA; MUSCLE; IMAGE | Adipose tissues; Body composition; CT segmentation; Skeletal muscle; Unsupervised domain adaptation | Computerized tomography; Diagnosis; Image analysis; Image coding; Image segmentation; Joints (anatomy); Network coding; Tissue engineering; Adipose tissue; Body composition; Computed tomography scan; Computed tomography segmentation; Cross-domain; Domain adaptation; Domain consistency; Skeletal muscle; Target domain; Unsupervised domain adaptation; Muscle | English | 2025 | 2025-01 | 10.1007/s00138-024-01615-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Accurate structural crack detection using NestedUNet from drone and handheld camera images | Crack detection has been significant in structural health monitoring and maintenance of concrete facilities. Many efforts have been made to automate the crack detection process using convolutional neural networks (CNNs). However, many previous CNN architectures and datasets have limitations that require improvements to reduce training time, GPU requirements, and model generalization capabilities. To mitigate these problems, we have developed a new dataset with different types of complex cracks utilizing a handheld camera and drone in different light, environmental conditions, and varying backgrounds. At the same time, we presented an enhanced CNN encoder-decoder architecture that achieves crack segmentation with higher accuracy with fewer parameters. To cope with spatial information loss effectively, we used nested skip connections in the encoder part, along with the EfficientNet-B7 encoder, for speed, accuracy enhancement, and parameter minimization. In the decoder part, residual convolution blocks are employed to alleviate the vanishing gradient problem and aid spatial information recovery. In addition, we added the convolutional block attention module (CBAM) within our architecture to enhance feature extraction by emphasizing crack details over the background. Experimental results demonstrate that our proposed method achieves a 96.15 % accuracy, 85.78 % precision, 82.23 % recall, and 84.00 % F1-score on our custom dataset. Comparisons with other models show that our model outperforms them on all evaluation matrices while having fewer parameters. © 2025 | Khan, Safran; Jan, Abdullah; Seo, Keonwon | PhD Student, Major in Civil Engineering, Civil and Environmental Engineering Department, Utah State University, Old Main Hill, Logan, United States; PhD Student, Major in Civil Engineering, School of Architectural, Civil, Environmental, and Energy Engineering, Kyungpook National University, Daegu, South Korea; Major in Civil Engineering, School of Architectural, Civil, Environmental, and Energy Engineering, Kyungpook National University, Daegu, South Korea | 58537330900; 58298899200; 59969286100 | kwseo@knu.ac.kr; | KSCE Journal of Civil Engineering | KSCE J CIV ENG | 1226-7988 | 1976-3808 | 29 | 9 | SCIE | ENGINEERING, CIVIL | 2024 | 2 | 53.8 | 0 | CBAM attention; CNN; Crack detection; Deep learning; Efficient net; Lightweight network; Nested skip connections; Segmentation | Cameras; Computer system recovery; Convolution; Convolutional neural networks; Decoding; Deep learning; Network architecture; Signal encoding; Structural health monitoring; Convolutional block attention module attention; Convolutional neural network; Deep learning; Efficient net; Hand-held cameras; Lightweight network; Nested skip connection; Segmentation; Spatial informations; Structural crack detection; Crack detection; Image segmentation | English | Final | 2025 | 10.1016/j.kscej.2025.100204 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Amine-Functionalized Carbonate Mortars of CO2 Absorption for Carbon Neutrality and Enhanced Rebar Corrosion Resistance | This study investigated the effects of carbon dioxide (CO2) uptake by dimethylamine (DMA), diethylamine (DEA) and isopropylamine (IPA) in amine-added cement mortars and the corrosion resistance of rebars covered with amine-added mortars in the presence of 4% calcium chloride solution. Quantitative findings showed that DEA at 2% demonstrated the highest CO2 uptake rate, which was 1.8 times faster than that of the control mortar. In corrosion tests, DMA and DEA mortars exhibited a 40-85% decrease in corrosion potential after 15 days compared to initial values, indicating improved corrosion resistance. However, in saltwater tests, all samples showed corrosion potential values below - 350 mV after 12 days, suggesting active corrosion. Qualitatively, the amines demonstrated improved corrosion resistance compared with the control samples, with DMA and DEA being more effective than IPA. This enhanced performance is attributed to the ability of amines, particularly DEA, to adsorb onto the surface of the rebar and form a protective layer, increasing the pH of the pore solution and potentially binding with chloride ions. This research presents a new model for the production of building materials using innovative technologies to reduce atmospheric carbon dioxide content while also enhancing durability. The study highlights the complex interplay between CO2 absorption, carbonation, and corrosion processes in amine-modified cementitious materials, providing valuable insights for developing more sustainable and durable concrete structures. | Kim, Tae-heon; Kuppusamy, Madhan; Park, Shin-Deuk; Kim, Sun-Woo; Park, Sung-Sik; Kim, Wha-Jung | Kyungpook Natl Univ, Dept Civil Engn, Daegu 41566, South Korea; GOONWORLD Corp Res Inst, Daegu 41065, South Korea; Chosun Univ, Dept Chem Educ, Gwangju 61452, South Korea | KUPPUSAMY, MADHAN/AEA-7121-2022; Kim, Tae/C-5935-2015; KIM, SUN/HSB-7040-2023 | 57204217686; 57203712410; 59446506900; 57089310400; 36241850300; 57203533494 | huny1016@krindus.co.kr; mitmadhan@gmail.com; yyy608ttn@naver.com; swookim@chosun.ac.kr; sungpark@knu.ac.kr; kimwj@knu.ac.kr; | INTERNATIONAL JOURNAL OF CIVIL ENGINEERING | INT J CIV ENG | 1735-0522 | 2383-3874 | 23 | 3 | SCIE | ENGINEERING, CIVIL | 2024 | 2 | 53.8 | 0 | 2025-05-07 | 0 | 0 | CO2 absorption; Amine-based catalyst; Saltwater exposure; Carbon neutrality; Rebar corrosion | REINFORCING STEEL; CAPTURE; BEHAVIOR | Amine-based catalyst; Carbon neutrality; CO<sub>2</sub> absorption; Rebar corrosion; Saltwater exposure | Atmospheric corrosion; Bars (metal); Bioremediation; Carbon capture; Carbon capture and storage; Carbon capture and utilization; Carbon sequestration; Carbonation; Concrete buildings; Corrosion protection; Corrosion resistance; Direct air capture; Pollution induced corrosion; Seawater corrosion; Zero-carbon; Amine-based catalyst; Carbon neutralities; CO 2 uptake; CO2 absorption; Diethylamines; Dimethylamines; Isopropylamine; Rebar corrosion; Saltwater exposure; ]+ catalyst; Mortar | English | 2025 | 2025-03 | 10.1007/s40999-024-01054-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Experimental study and finite element model of 3-ply bellows expansion joints system subjected to monotonic load | Piping systems are vital in various industries and infrastructure networks but are vulnerable to damage from seismic activity, liquefaction, ground subsidence, and other factors. Damage to piping systems occurs mainly at the connections due to earthquakes, ground subsidence, and liquefaction. To ensure the safety of piping systems, this study developed a 3-ply bellows expansion joint capable of withstanding deformation caused by earthquakes. In high load conditions, while a transitional 1-ply bellows expansion joint must be thickened for durability, the 3-ply bellows expansion joint is more accessible to manufacture and provides superior fatigue resistance. The seismic deformation performance of 3-ply bellows expansion joints was evaluated by performing four monotonic loading tests: tensile-compression, shear, and bending. Additionally, the complex behavior of a 3ply bellows expansion joint was expressed by creating a simplified finite element model. Based on this, the finite element model was validated using bending monotonic loading test data for a piping system with two bellows expansion joints, and it was confirmed that the results were in good agreement. The constructed finite element model can serve as a tool for understanding the integrated behavior of piping systems, including the 3-ply bellows expansion joints. | Kim, Dongchang; Jeon, Bub-gyu; Jeong, Young-soo; Eem, Seunghyun; Yu, Jinseok | Kyungpook Natl Univ, Dept Convergence & Fus Syst Engn, Major Plant Syst Engn, Daegu 41566, South Korea; Pusan Natl Univ, Seism Res & Test Ctr, Yangsan 50612, South Korea; Taesungflexible Co, Gimhae 50875, South Korea | 58487965700; 54961482000; 53163674500; 52363442900; 59797732000 | eemsh@knu.ac.kr; | KSCE JOURNAL OF CIVIL ENGINEERING | KSCE J CIV ENG | 1226-7988 | 1976-3808 | 29 | 7 | SCIE | ENGINEERING, CIVIL | 2024 | 2 | 53.8 | N/A | 0 | 0 | Piping systems; 3-Ply bellows expansion joint; Monotonic loading test; Finite element model; Simplified | 3-Ply bellows expansion joint; Finite element model; Monotonic loading test; Piping systems; Simplified | 3-ply bellow expansion joint; Bellows expansion joint; Finite element modelling (FEM); Industry networks; Joint system; Loading tests; Monotonic load; Monotonic loading; Monotonic loading test; Simplified; Earthquake effects | English | 2025 | 2025-07 | 10.1016/j.kscej.2024.100152 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | A Phase 2, Multi-Center, Randomized, Double-Blind, Parallel-Group Trial to Evaluate the Efficacy and Safety of CKD-495 in Patients With Acute and Chronic Gastritis | CKD-495 is a newly developed drug extracted from Cinnamomum cassia Presl. This phase II study assessed the clinical benefits of CKD-495 in the treatment of acute and chronic gastritis. This study randomly assigned 250 patients with endoscopically-proven gastric mucosal erosion to five groups. The groups received either 75 mg or 150 mg of CKD-495, 100 mg of rebamipide, 60 mg of Artemisiae argyi folium 95% ethanol ext. (20 -> 1) (Stillen; Dong-A ST Co., Ltd., Seoul, Korea), or placebo for 2 weeks, respectively. The primary endpoint was the erosion improvement rate, and the secondary endpoints were erosion cure rates, improvement rates of gastrointestinal symptoms, edema, redness, and hemorrhage. Drug-related adverse events were evaluated. The endoscopic erosion improvement rate was significantly higher in the 75 mg CKD-495 group than in the other groups in both the full analysis set (73% vs. 41%, 45%, 52%, 48% for the 75 mg CKD-495, 150 mg CKD-495, placebo, 60 mg Stillen, and 100 mg rebamipide groups, respectively) and the per-protocol set (PPS) (75% vs. 37%, 45%, 51%, 50%). The cure rate of gastric erosion was significantly higher in the 75 mg CKD-495 group than in the other groups. The improvement rates of hemorrhage erosion were significantly higher in the 150-mg CKD-495 group. No significant differences were observed in the safety profiles. No serious adverse events or drug reactions were observed. These results demonstrate that 75 mg of CKD-495 has excellent efficacy for the treatment of endoscopic and symptomatic improvements for acute and chronic gastritis.Trial Registration: ClinicalTrials.gov identifier: NCT03437785 | Park, Su Hyun; Lee, Oh Young; Lee, Yong Chan; Park, Kyung Sik; Park, Jong Jae; Park, Moo In; Song, Geun Am; Lee, Dong Ho; Jung, Hyunsoo; Kim, Sung Kook; Kim, Tae Nyeun; Choi, Suck-Chei; Jee, Sam Ryong; Rew, Jong Sun; Lee, Soo Teik; Choi, Eun Kwang; Baik, Gwang Ho; Park, Shin Jung | Hanyang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Yonsei Univ, Severance Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Keimyung Univ, Coll Med, Dept Internal Med, Daegu, South Korea; Korea Univ, Guro Hosp, Dept Internal Med, Seoul, South Korea; Kosin Univ, Coll Med, Dept Internal Med, Busan, South Korea; Pusan Natl Univ, Sch Med, Dept Internal Med, Busan, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam Si, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Yeungnam Univ, Coll Med, Dept Internal Med, Daegu, South Korea; Wonkwang Univ, Coll Med, Dept Internal Med, Iksan, South Korea; Inje Univ, Busan Paik Hosp, Coll Med, Dept Internal Med, Pusan, South Korea; Chonnam Natl Univ, Chonnam Natl Univ Hosp, Dept Internal Med, Med Sch, Gwangju, South Korea; Chonbuk Natl Univ Hosp, Dept Internal Med, Jeonju, South Korea; Jeju Natl Univ, Dept Internal Med, Sch Med, Jeju, South Korea; Hallym Univ, Chuncheon Sacred Heart Hosp, Dept Internal Med, Chunchon, South Korea; Chong Kun Dang Pharmaceut Corp, Chong Kun Dang Res Inst, Seoul, South Korea | 57250673200; 57252457600; 57230987200; 59735507200; 34668368400; 8666034000; 56803090800; 59047680300; 59735672500; 34770060400; 8449938100; 7408119608; 14621389400; 7004014155; 7601418502; 25930823000; 7801423477; 55889967400 | leeoy@hanyang.ac.kr; | CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | CAN J GASTROENTEROL | 2291-2789 | 2291-2797 | 2025 | 1 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2024 | 2.3 | 54.1 | 0 | 2025-05-07 | 0 | 0 | ARTEMISIA-ASIATICA; HELICOBACTER-PYLORI; EROSIVE GASTRITIS; DA-9601; REBAMIPIDE; EXTRACT; PATHOGENESIS; ACTIVATION; ACID | Acute Disease; Adult; Aged; Alanine; Anti-Ulcer Agents; Chronic Disease; Double-Blind Method; Female; Gastric Mucosa; Gastritis; Humans; Male; Middle Aged; Plant Extracts; Quinolones; Treatment Outcome; antibiotic agent; artemisiae argyi folium extract; ckd 495 agent; plant extract; rebamipide; stillen; unclassified drug; alanine; antiulcer agent; plant extract; quinolone derivative; rebamipide; abdominal distension; adult; anorexia; Article; blood analysis; chronic gastritis; cold sweat; controlled study; diarrhea; dizziness; double blind procedure; drug efficacy; drug safety; duodenitis; dyspepsia; edema; endoscopy; eructation; esophagogastroduodenoscopy; female; gastrointestinal discomfort; heartburn; human; major clinical study; male; middle aged; multicenter study; nausea and vomiting; phase 2 clinical trial; postprandial discomfort; randomized controlled trial; skin redness; stomach erosion; stomach ulcer; thorax pain; urinalysis; acute disease; aged; chronic disease; clinical trial; drug effect; drug therapy; gastritis; pathology; stomach mucosa; treatment outcome | English | 2025 | 2025 | 10.1155/cjgh/2702089 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | Endoscopic vacuum therapy for gastrointestinal transmural defects: a literature review | Endoscopic vacuum therapy (EVT) has emerged as a transformative approach for managing gastrointestinal (GI) transmural defects, offering a less invasive and more promising alternative to surgery. Initially developed to address anastomotic leaks after rectal surgery, the application of EVT has expanded to include other locations within the GI tract. This review investigated the principles, indications, procedures, outcomes, challenges, and future perspectives of EVT for the management of GI transmural defects. In conclusion, EVT has demonstrated favorable outcomes in GI defect closure, with reduced complications, shortened hospital stay, and decreased morbidity rates as compared with conventional treatments. Although EVT faces challenges in some specific anatomical locations and in managing severe complications such as major bleeding, ongoing advancements in technology and standardization efforts offer promise for broader indications and better outcomes. Future perspectives include exploring novel EVT devices, refining patient selection criteria and pre-emptive applications, and standardizing procedural protocols. | Le, Tan Minh; Tran, Van Huy; Chung, Kyu Sung; Jeon, Seong Woo | Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, BK21 Four Program, Daegu, South Korea; Hue Univ, Univ Med & Pharm Hosp, Gastroenterol & Endoscopy Ctr, Hue, Vietnam; Kyungpook Natl Univ, Sch Med, Dept Internal Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea | Jeon, Seongwoo/AAU-4618-2020; Le, Tan/ITT-2150-2023 | 57870749600; 56448091600; 59713113900; 9733636500 | swjeon@knu.ac.kr; | CLINICAL ENDOSCOPY | CLIN ENDOSC | 2234-2400 | 2234-2443 | 58 | 2 | ESCI | GASTROENTEROLOGY & HEPATOLOGY | 2024 | 2.3 | 54.1 | 0 | 2025-05-07 | 0 | 0 | Anastomotic leak; Endoscopy; Gastrointestinal tract; Therapeutics; Vacuum | ESOPHAGEAL ANASTOMOTIC LEAKS; PRESSURE WOUND THERAPY; ASSISTED CLOSURE; MANAGEMENT; PERFORATIONS; OPTION; SYSTEM | Anastomotic leak; Endoscopy; Gastrointestinal tract; Therapeutics; Vacuum | anastomosis leakage; anatomical location; aortic aneurysm endovascular graft; complication; endoscopy; gastrointestinal endoscopy; gastrointestinal tract; hospitalization; human; major bleeding; patient selection; review; standardization; surgery; therapy; vacuum; vacuum assisted closure | English | 2025 | 2025-03 | 10.5946/ce.2024.150 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Phase 2 Open-label, Single-arm, Multi-center Clinical Trial to Evaluate the Efficacy and Safety of Camostat Mesylate in Patients with Protein-losing Enteropathy After Fontan Operation | Protein-losing enteropathy (PLE) is a serious complication after the Fontan operation with limited treatment options. This phase 2, multi-center, open-label trial evaluated the efficacy and safety of Camostat Mesylate (CM), a serine protease inhibitor, as adjunctive therapy for PLE. Nineteen patients aged 4 years and older with PLE after the Fontan operation were enrolled. CM was administered for six months in addition to their individualized conventional treatments. Assessments were made at 1, 3, and 6 months of CM administration, and at one month after CM discontinuation. Outcomes evaluated were the changes in serum albumin level, stool alpha-1 antitrypsin, and clinical symptoms such as, diarrhea, edema, weight change, and ascites. Of the 19 patients enrolled, 4 voluntarily withdrew consent, and the data from the 15 patients who completed the study were analyzed. Their median age was 15.0 years (interquartile range, 12.0–21.5) and the median time between the Fontan surgery and PLE diagnosis was 2.4 years. Serum albumin levels increased from 2.2 to 2.5 g/dL (p = 0.183), while stool alpha-1 antitrypsin levels significantly decreased from 215.6 to 75.5 mg/dL (p = 0.016) over six months. Patients with baseline diarrhea showed notable improvements: serum albumin increased from 1.8 to 2.4 g/dL (p = 0.138) and stool alpha-1 antitrypsin decreased from 220.3 to 75.5 mg/dL (p = 0.075) over 6 months. No serious adverse events occurred. CM demonstrated significant reductions in gastrointestinal protein losses, particularly in patients with baseline diarrhea. Trial registration NCT05474664. © The Author(s) 2025. | Park, Woo Young; Kim, Gi Beom; Lee, Sang Yun; Baek, Jae Suk; Kim, Soo Jin; Jung, Jowon; Hyun, Myung Chul; Lim, Young Tae; Lee, HyoungDoo; Ko, Hoon; Lee, Joowon | Department of Pediatrics, Seoul National University Children’s Hospital, Seoul National University College of Medicine, 101, Daehak-Ro, Jongno-Gu, Seoul, South Korea; Department of Pediatrics, Seoul National University Children’s Hospital, Seoul National University College of Medicine, 101, Daehak-Ro, Jongno-Gu, Seoul, South Korea; Department of Pediatrics, Seoul National University Children’s Hospital, Seoul National University College of Medicine, 101, Daehak-Ro, Jongno-Gu, Seoul, South Korea; Department of Pediatrics, Asan Medical Center Children’s Hospital, Ulsan University College of Medicine, Seoul, South Korea; Department of Pediatrics, Sejong General Hospital, Bucheon, South Korea; Department of Pediatrics, Yonsei University College of Medicine, Seoul, South Korea; Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Pediatrics, Pusan National University College of Medicine, Yangsan, South Korea; Department of Pediatrics, Pusan National University College of Medicine, Yangsan, South Korea; Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, South Korea | 57221332706; 35559009600; 59288335400; 35782787900; 57197827818; 8893465100; 8704315000; 57197274340; 56568700700; 57193211185; 58606986900 | ped9526@snu.ac.kr; | Pediatric Cardiology | PEDIATR CARDIOL | 0172-0643 | 1432-1971 | SCIE | CARDIAC & CARDIOVASCULAR SYSTEMS;PEDIATRICS | 2024 | 1.4 | 54.2 | 0 | 2025-05-07 | 0 | Camostat mesylate; Fontan operation; Protein-losing enteropathy; Stool alpha-1 antitrypsin | English | Article in press | 2025 | 10.1007/s00246-025-03859-9 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | Article | Clinical and Radiologic Outcomes of Single-level Decompression by Unilateral Endoscopic Biportal Technique in Degenerative Spinal Stenosis: Over 5-year Follow-up | Study Design: Retrospective. Objective: To report radiologic and clinical outcomes of single-level unilateral biportal endoscopic (UBE) decompression over 5 years for degenerative lumbar spinal stenosis (LSS) without instability. Summary of Background Data: UBE decompression has recently been introduced as a surgical treatment for LSS without instability. UBE has been shown in studies to have advantages in the prevention of infection and early rehabilitation. However, there is no long-term follow-up study. Methods: One hundred twenty-seven patients who underwent UBE decompression for single-level LSS with at least 5 years of follow-up were analyzed. Clinical outcomes including Oswestry Disability Index (ODI), Visual analog system (VAS), modified MacNab criteria, time to ambulation, operative time, and length of hospital stay were investigated. The radiologic outcome was assessed by dynamic plain radiographs. Results: ODI improved from 63.2±10.7 before surgery to 18.8±9.2 after 5 years of follow-up (P<0.001). Leg VAS decreased from 7.3±0.7 before surgery to 1.75±0.5 at the last follow-up (P<0.001). Per modified Macnab criteria, only 9.4% (12/127) showed poor clinical results. There were no infections, but there were 4 cases (3%) of dura tear and 1 case (0.07%) of transient palsy. Intervertebral angle showed significant change from preoperative to final follow-up, 6.3 ±3.2-5.2 ±3.5 degrees. (P=0.012). The intervertebral distance also showed a significant difference from 10.5±2.3 mm before surgery to 9.1±2.2 mm after surgery. (P=0.005). No significant changes in dynamic stability occurred. Among 127 patients, revision surgery was performed in 9 cases (7%). Conclusions: UBE decompression of LSS without instability demonstrated good clinical outcomes over 5 years and did not show significant segmental instability after surgery. Although revision surgery was performed after UBE decompression, there were no severe complications, and revision rates were similar to other techniques. UBE is considered to be an alternative technique to microscopic and traditional decompression in LSS. © 2025 Wolters Kluwer Health, Inc. | Kim, Ju-Eun; Park, Eugene J.; Park, Daniel K. | Baroseomyeon Hospital, Busan, South Korea; Department of Orthopedic Surgery, Kyungpook National University Hospital, Kyungpook National University, School of Medicine, Daegu, South Korea; Michigan Orthopedic Surgeons, Southfield, MI, United States | 56487007900; 55371642100; 24336011200 | dspfuture@hanmail.net; danparkmd@gmail.com; | Clinical Spine Surgery | CLIN SPINE SURG | 2380-0186 | 2380-0186 | SCIE | CLINICAL NEUROLOGY;ORTHOPEDICS | 2024 | 1.7 | 54.3 | 0 | 2025-05-07 | 0 | biportal; endoscopic; laminectomy; spinal stenosis | English | Article in press | 2025 | 10.1097/bsd.0000000000001776 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | Article | Correlation between Clinical Improvement and Dural Sac Cross-Sectional Area Expansion in Biportal Endoscopic Lumbar Decompression | Study Design: Retrospective study. Objective: To correlate the changes in the dural area on MRI and clinical outcome after unilateral biportal endoscopic (UBE) decompression. Summary of Background Data: Clinical outcomes after UBE decompression have been published for up to 2 years for patients with isolated spinal stenosis at 1 level. Serial dural expansion after UBE decompression has not been published as well as correlation to clinical outcomes. Method: We retrospectively reviewed the clinical and radiologic outcomes of 86 patients who underwent UBE decompression for spinal stenosis. Preoperative and postoperative visual analog score (VAS) and Oswestry Disability Index (ODI) were analyzed, and MRI was used for radiologic evaluation before surgery, 3 days after surgery, and 2 years after surgery. The correlation of dural spinal area CSA (preoperative-final) and difference of clinical outcome (preoperative-final) were analyzed. Result: None of the 86 patients had permanent neurological complications. Back VAS, leg VAS, and ODI showed improvement in symptoms postoperatively and 2 years postoperatively. The postoperative CSA of the dural sac on MRI was statistically significantly increased after surgery at all time points. VAS leg was moderately correlated with change in CSA, while ODI and VAS back were weakly correlated. Correlations were all statistically significant. Conclusion: UBE decompression showed good clinical outcomes similar to previous studies, and the CSA of the dural sac on MRI significantly increased in the late postoperative phase compared with the early postoperative phase. This technique is viable option to achieve radiographic dural expansion and improvement in clinical outcomes in degenerative lumbar spinal stenosis. However, there is at best only a moderate correlation with change in CSA and clinical outcomes. © 2025 Wolters Kluwer Health, Inc. | Kim, Ju-Eun; Park, Daniel K.; Park, Eugene J. | Baroseomyeon Hospital, Busan, South Korea; Michigan Orthopedic Surgeons, Orthopedic Surgery, Southfield, MI, United States; Department of Orthopedic Surgery, Kyungpook National University Hospital, Kyungpook National University, School of Medicine, Daegu, South Korea | 56487007900; 24336011200; 55371642100 | danparkmd@gmail.com; | Clinical Spine Surgery | CLIN SPINE SURG | 2380-0186 | 2380-0186 | SCIE | CLINICAL NEUROLOGY;ORTHOPEDICS | 2024 | 1.7 | 54.3 | 0 | 2025-05-07 | 0 | endoscopic; laminectomy; spinal stenosis | English | Article in press | 2025 | 10.1097/bsd.0000000000001789 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Current concepts in arthroscopic rotator cuff repair | Rotator cuff repair has experience great development, transitioning from open surgical techniques to minimally invasive arthroscopic methods. This review explores its historical development, current repair techniques, biomechanical considerations, and advances in materials and biological augmentation. It also addresses strategies for managing partial-thickness and massive tears, compares single-row and double-row repairs, and highlights the importance of individualized postoperative rehabilitation. By integrating biomechanical precision with biological innovations, modern rotator cuff repair aims to improve healing rates, reduce retear risk, and optimize functional outcomes. | Lee, Kang-San; Kim, Dong-Hyun; Chung, Seok Won; Yoon, Jong Pil | W Gen Hosp, Dept Orthoped Surg, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Orthoped Surg, Daegu, South Korea; Konkuk Univ Med Ctr, Dept Orthoped Surg, Seoul, South Korea | 58967020700; 57198637188; 37065938600; 36098548400 | altjp@hanmail.net; | CLINICS IN SHOULDER AND ELBOW | CLIN SHOULDER ELB | 2288-8721 | 28 | 1 | ESCI | ORTHOPEDICS | 2024 | 1.7 | 54.3 | 0 | 2025-05-07 | 0 | 0 | Shoulder; Rotator cuff; Rotator cuff injuries | DOUBLE-ROW; SINGLE-ROW; SUPRASPINATUS TENDON; TRANSOSSEOUS SUTURE; TEARS; SHOULDER; FIXATION; ACROMIOPLASTY; FOOTPRINT; INTEGRITY | Rotator cuff; Rotator cuff injuries; Shoulder | English | 2025 | 2025-02 | 10.5397/cise.2025.00010 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Article | A multi-platform based metabolic comparison of dill (Anethum graveolens) and fennel (Foeniculum vulgare) using NMR and UPLC–QTOF/MS | Fennel and dill are well-known aromatic plants and are widely used commercially. They have also been recognized as a medicinal herb with numerous pharmacological activities. Thus, the interest in dill and fennel has been growing, and their industrial use is becoming more important. In this study, seeds of fennel and dill were extracted and analyzed using nuclear magnetic resonance (NMR) spectroscopy and ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UPLC–QTOF/MS)-based metabolomics. Through 1D and 2D NMR analysis, a total of 34 primary metabolites were identified, and using UPLC–QTOF/MS, different chromatograms of dill and fennel were obtained in less than 20 min. In the multivariate statistical analysis of data obtained from NMR and MS, it was confirmed that seeds of dill and fennel discriminated clearly. Sugars and organic acids were identified as the primary metabolites contributing to significant differentiation of fennel and dill. Also, flavonoids, which were identified as secondary metabolites, significantly differentiated dill and fennel. © The Author(s) 2025. | Choi, Bo-Ram; Yoon, Dahye; Shin, Woo Cheol; Jang, Jin-Kyu; Lee, Sookyeong; Lee, Dae Young | Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong, 27709, South Korea; Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, RDA, Eumseong, 27709, South Korea; BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, 41566, South Korea; BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, 41566, South Korea; National Agrobioaffiliationersity Center, National Institute of Agricultural Sciences, RDA, Jeonju, 54874, South Korea; BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu, 41566, South Korea | 57194340567; 55855383700; 57212601607; 58756632600; 57219089483; 57750904900 | dylee80@knu.ac.kr; | Journal of Plant Biochemistry and Biotechnology | J PLANT BIOCHEM BIOT | 0971-7811 | 0974-1275 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;PLANT SCIENCES | 2024 | 1.5 | 54.4 | 0 | 2025-05-07 | 0 | Dill; Fennel; Metabolomics; NMR spectroscopy; UPLC–QTOF/MS | English | Article in press | 2025 | 10.1007/s13562-025-00962-z | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | Review | Early prediction of disease in soybeans by state-of-the-art machine vision technology | Early prediction and identification of disease in any crop is essential to prevent severe damage and enhance crop productivity. Traditional method of disease identification poses a significant challenge in terms of accuracy, time consumption and real-time detection. Computer vision including image-based analysis has been an alternative to the traditional methods for efficient, convenient, and precise disease prediction at an early stage. With the advancement in machines, technologies, camera sensors, and analysis techniques like machine learning (ML) and deep learning (DL), image-based plant disease identification has become more accurate, efficient and applicable in agriculture. The imagery data obtained from digital, spectral, and thermal images are subjected to analysis through the use of algorithms or ML and DL methods. In this review we have summarized how the integration of computer vision and artificial intelligence (ML and DL) can be used for precisely predicting the disease incidence in soybean at an early stage. Recent studies conducted regarding early prediction of soybean disease, along with the challenges and limitations and their possible solutions, have also been described. The purpose of this study is to integrate the studies on the early identification of disease in soybeans along with advancement in precision agriculture. The practical applicability of smart farming systems and their integration with sensors and the Internet of Things have also been described. This study would help the researchers understand the use of computer vision integrated with ML and DL for the early prediction of soybean disease. © The Author(s), under exclusive licence to Korean Society of Crop Science (KSCS) 2025. | Ghimire, Amit; Kim, Yoonha | Department of Applied Biosciences, Kyungpook National University, Daegu, 41566, South Korea, Department of Integrative Biology, Kyungpook National University, Daegu, 41566, South Korea; Department of Applied Biosciences, Kyungpook National University, Daegu, 41566, South Korea, Department of Integrative Biology, Kyungpook National University, Daegu, 41566, South Korea, Upland Field Machinery Research Center, Kyungpook National University, Daegu, 41566, South Korea | 57823220200; 57224866763 | kyh1229@knu.ac.kr; | Journal of Crop Science and Biotechnology | J CROP SCI BIOTECHN | 1975-9479 | 2005-8276 | ESCI | PLANT SCIENCES | 2024 | 1.5 | 54.4 | 0 | 2025-05-07 | 0 | Deep learning; Diseases; Machine learning; Prediction; Soybean | English | Article in press | 2025 | 10.1007/s12892-025-00285-4 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | Review | Emerging role of circular RNAs in diabetic retinopathy | Diabetic retinopathy (DR), a significant complication that affects the retina of individuals with diabetes, poses a severe threat to their visual health. DR is classified into stages ranging from non-proliferative to proliferative forms. As the disease progresses, pathological neovascularization and hemorrhage in the retina or vitreous can occur, potentially leading to vision impairment or blindness. Current treatments for DR include intravitreal injections of anti-vascular endothelial growth factor drugs and surgical interventions such as laser photocoagulation. However, these treatments are associated with various complications and side effects. Therefore, cellular and epigenetic studies are necessary to better understand the pathogenesis of DR, which may lead to the development of novel therapeutic strategies. Several studies have demonstrated the role of circular RNAs (circRNAs) in the pathogenesis and progression of DR. CircRNAs have been shown to regulate the expression of genes involved in the proliferation, differentiation, or angiogenesis of different retinal cells, thereby influencing their function. Therefore, this review aims to investigate the role of circRNAs in different retinal cell types in DR and evaluate their potential as diagnostic and therapeutic targets for the disease. Copyright © Korean J Physiol Pharmacol | Kim, Hyunjong; Ryu, Juhee | Vessel-Organ Interaction Research Center, College of Pharmacy, Kyungpook National University, Daegu, 41566, South Korea, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 41566, South Korea; Vessel-Organ Interaction Research Center, College of Pharmacy, Kyungpook National University, Daegu, 41566, South Korea, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 41566, South Korea | 57956633200; 57208255566 | juheeryu@knu.ac.kr; | Korean Journal of Physiology and Pharmacology | KOREAN J PHYSIOL PHA | 1226-4512 | 2093-3827 | 29 | 4 | SCIE | PHARMACOLOGY & PHARMACY;PHYSIOLOGY | 2024 | 2.2 | 54.6 | 0 | Circular RNA; Diabetic retinopathy; Endothelial cells; Noncoding RNA; Retinal pigment epithelial cell | circular ribonucleic acid; untranslated RNA; vasculotropin; angiogenesis; cell differentiation; diabetic retinopathy; endothelium cell; human; intravitreal drug administration; laser coagulation; neovascularization (pathology); pathogenesis; retina pigment cell; review; visual impairment; vitreous body | English | Final | 2025 | 10.4196/kjpp.24.389 | 바로가기 | 바로가기 | 바로가기 |
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