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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Review | Non-Coding RNAs as Potential Targets for Diagnosis and Treatment of Oral Lichen Planus: A Narrative Review | Oral lichen planus (OLP) is a chronic inflammatory disease that is characterized by the infiltration of T cells into the oral mucosa, causing the apoptosis of basal keratinocytes. OLP is a multifactorial disease of unknown etiology and is not solely caused by the malfunction of a single key gene but rather by various intracellular and extracellular factors. Non-coding RNAs play a critical role in immunological homeostasis and inflammatory response and are found in all cell types and bodily fluids, and their expression is closely regulated to preserve normal physiologies. The dysregulation of non-coding RNAs may be highly implicated in the onset and progression of diverse inflammatory disorders, including OLP. This narrative review summarizes the role of non-coding RNAs in molecular and cellular changes in the oral epithelium during OLP pathogenesis. | Kim, Tae-Jun; Kim, Yu Gyung; Jung, Won; Jang, Sungil; Ko, Hyoung-Gon; Park, Chan Ho; Byun, Jin-Seok; Kim, Do-Yeon | Kyungpook Natl Univ, Sch Dent, Dept Pharmacol, Daegu 41940, South Korea; Jeonbuk Natl Univ, Inst Oral Biosci, Sch Dent, Dept Oral Med, Jeonju 54896, South Korea; Jeonbuk Natl Univ, Sch Dent, Inst Oral Biosci, Dept Oral Biochem, Jeonju 54896, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Anat & Neurobiol, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Dent Biomat, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral Med, Daegu 41940, South Korea | ; Ko, Hyoung-Gon/KQU-8680-2024; Kim, Do-Yeon/AET-3021-2022; Jung, Won/GRN-8894-2022; Kim, Yong-Tae/HQZ-0240-2023; Jang, Sungil/AGS-7671-2022; Kim, Young-Bo/AAR-8052-2021 | 57200911346; 57221687604; 57203126364; 55469340300; 14522654800; 55728043300; 55430621800; 57203012542 | jsbyun@knu.ac.kr;dykim82@knu.ac.kr; | BIOMOLECULES | BIOMOLECULES | 2218-273X | 13 | 11 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2023 | 4.8 | 21.2 | 0.29 | 2025-06-25 | 6 | 7 | oral lichen planus; microRNA; long non-coding RNA; circular RNA; inflammation; T lymphocyte | NF-KAPPA-B; T-CELL RESPONSES; MESSENGER-RNA; CIRCULAR RNAS; MALIGNANT-TRANSFORMATION; ALTERED EXPRESSION; ANTITUMOR-ACTIVITY; MONONUCLEAR-CELLS; GENE-EXPRESSION; ACTIVATION | circular RNA; inflammation; long non-coding RNA; microRNA; oral lichen planus; T lymphocyte | Apoptosis; Humans; Keratinocytes; Lichen Planus, Oral; Mouth Mucosa; T-Lymphocytes; circular ribonucleic acid; hypoxia inducible factor 1alpha; long untranslated RNA; mammalian target of rapamycin; microRNA; microRNA 146a; microRNA 155; peptides and proteins; transcription factor FOXP3; TRIM21; unclassified drug; apoptosis; body fluid; CD4+ T lymphocyte; CD8+ T lymphocyte; cell proliferation; homeostasis; human; keratinocyte; mouth mucosa; oral lichen planus; regulatory T lymphocyte; Review; T lymphocyte; Th1 cell; Th17 cell; Th2 cell; genetics; oral lichen planus; pathology | English | 2023 | 2023-11 | 10.3390/biom13111646 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Pyroptosis-Mediated Damage Mechanism by Deoxynivalenol in Porcine Small Intestinal Epithelial Cells | Deoxynivalenol (DON) is known as a vomitoxin, which frequently contaminates feedstuffs, such as corn, wheat, and barley. Intake of DON-contaminated feed has been known to cause undesirable effects, including diarrhea, emesis, reduced feed intake, nutrient malabsorption, weight loss, and delay in growth, in livestock. However, the molecular mechanism of DON-induced damage of the intestinal epithelium requires further investigation. Treatment with DON triggered ROS in IPEC-J2 cells and increased the mRNA and protein expression levels of thioredoxin interacting protein (TXNIP). To investigate the activation of the inflammasome, we confirmed the mRNA and protein expression levels of the NLR family pyrin domain containing 3 (NLRP3), apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and caspase-1 (CASP-1). Moreover, we confirmed that caspase mediates the mature form of interleukin-18, and the cleaved form of Gasdermin D (GSDMD) was increased. Based on these results, our study suggests that DON can induce damage through oxidative stress and pyroptosis in the epithelial cells of the porcine small intestine via NLRP3 inflammasome. | Kang, Tae Hong; Shin, Sangsu; Park, JeongWoong; Lee, Bo Ram; Lee, Sang In | Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; Kyungpook Natl Univ, Res Ctr Horse Ind, Sangju 37224, South Korea; Kyungpook Natl Univ, Dept Anim Biotechnol, Sangju 37224, South Korea; Rural Dev Adm, Natl Inst Anim Sci, Anim Biotechnol Div, Wonju 55365, South Korea | 57903443800; 55490360000; 58198744600; 56124581700; 57203597336 | mir88@korea.kr;silee78@knu.ac.kr; | TOXINS | TOXINS | 2072-6651 | 15 | 4 | SCIE | FOOD SCIENCE & TECHNOLOGY;TOXICOLOGY | 2023 | 3.9 | 21.2 | 1.4 | 2025-06-25 | 10 | 10 | deoxynivalenol; intestinal epithelial cell; porcine; pyroptosis | BARRIER INTEGRITY; OXIDATIVE STRESS; IL-1-BETA; CASPASES; INJURY; GSDMD; TIME | deoxynivalenol; intestinal epithelial cell; porcine; pyroptosis | Animals; Caspase 1; Caspases; Epithelial Cells; Inflammasomes; Intestine, Small; NLR Family, Pyrin Domain-Containing 3 Protein; Pyroptosis; RNA, Messenger; Swine; antioxidant; catalase; cryopyrin; cytokine; gasdermin; glutamate cysteine ligase; inflammasome; interleukin 18; interleukin 1beta; interleukin 1beta converting enzyme; messenger RNA; reactive oxygen metabolite; superoxide dismutase; thioredoxin interacting protein; vomitoxin; caspase; cryopyrin; inflammasome; interleukin 1beta converting enzyme; messenger RNA; vomitoxin; animal cell; apoptosis; Article; body weight loss; cell culture; cell death; cell viability; controlled study; cryopreservation; diarrhea; food intake; gene expression; IC50; immunocytochemistry; immunofluorescence; intestine epithelium cell; IPEC-J2 cell line; malabsorption; mRNA expression level; nonhuman; nutrient; oxidative stress; pig; protein expression; pyroptosis; real time polymerase chain reaction; RNA extraction; small intestine; vomiting; Western blotting; animal; epithelium cell; genetics; metabolism; pig; small intestine | English | 2023 | 2023-04 | 10.3390/toxins15040300 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article; Proceedings Paper | Simulation of Electron-Hole Pairs Created by ?-Rays Interaction in Scintillation Crystals Using Geant4 Toolkit | Understanding the electron-hole pair (e-h pair) production process in scintillators is essential for further studies of the scintillation mechanism. The number of e-h pairs can be derived from theoretical and empirical approaches. However, simulation approaches have been chosen to study all the related physical processes and spatial information in scintillation crystals. Due to the complexity of particle interaction and physical properties of solid-state, the simulation approach could be better than the analytical approach. This work aims to develop a Geant4-based simulation toolkit for studying scintillation mechanisms in single-crystalline scintillators since Geant4 can accurately calculate particle energy loss. Due to the lack of a solid-state physics model for insulators, the plasmon creation and phonon loss process for electrons are implemented in the Geant4 toolkit. The electrons, which are created by ?-rays interaction in crystals, can make further ionization to generate secondary electrons or create plasmons, or lose energy to phonons. Then the created plasmons decay into e-h pairs. These electrons and holes are tracked with information on energy and position. Therefore, the number of created e-h pairs and their spatial distribution can be extracted. In this work, we will present the result of the creation process of e-h pairs per MeV in scintillation crystals induced by ?-rays interaction. The number of e-h pairs created by ? ray in some popular inorganic crystals has been calculated. Assuming maximum conversion efficiency from the e-h pair to the luminescence light, we can calculate the maximum light yield of the intrinsic scintillator. | Luan, Nguyen Thanh; Kim, Hong Joo; Vuong, Phan Quoc | Kyungpook Natl Univ, Dept Phys, Daegu, South Korea | Kim, Hong Joo/AAE-1178-2022; Thanh Duong, Nguyen/AGY-4248-2022 | 57210576969; 59051568100; 57207618553 | thanhluan.ngtl@gmail.com;hongjoo@knu.ac.kr; | IEEE TRANSACTIONS ON NUCLEAR SCIENCE | IEEE T NUCL SCI | 0018-9499 | 1558-1578 | 70 | 7 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;NUCLEAR SCIENCE & TECHNOLOGY | 2023 | 1.9 | 21.2 | 0.15 | 2025-06-25 | 2 | 2 | Electron-hole pair (e-h pair); Geant4; inorganic scintillation; longitudinal optical (LO) phonon; Monte-Carlo simulation; plasmon | ENERGY-RESOLUTION SCINTILLATOR; TEMPERATURE-DEPENDENCE; LIGHT YIELD; PURE CSI; EFFICIENCY; CE3+; NAI(TL); PHOTON | Electron-hole pair (e-h pair); Geant4; inorganic scintillation; longitudinal optical (LO) phonon; Monte-Carlo simulation; plasmon | Electrons; Energy dissipation; Intelligent systems; Ionization; Monte Carlo methods; Phonons; Scintillation; Scintillation counters; Charge carriers process; Electron hole pairs; Geant4; Geant4 toolkits; Inorganic scintillation; Inorganics; Longitudinal optical phonons; Monte Carlo's simulation; Scintillation crystals; Scintillation mechanisms; Plasmons | English | 2023 | 2023-07 | 10.1109/tns.2023.3271328 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | TLR/MyD88-Mediated Inflammation Induced in Porcine Intestinal Epithelial Cells by Ochratoxin A Affects Intestinal Barrier Function | The intestinal epithelium performs vital functions such as nutrient absorption and acting as an intestinal barrier to maintain the host's homeostasis. Mycotoxin, which affects the processing and storage of animal feedstuff, is a problematic pollutant in farming products. Ochratoxin A generated by Aspergillus and Penicillium fungi causes inflammation, intestinal dysfunction, decline in growth, and reduced intake in porcine and other livestock. Despite these ongoing problems, OTA-related studies in intestinal epithelium are lacking. This study aimed to demonstrate that OTA regulates TLR/MyD88 signaling in IPEC-J2 cells and induces barrier function impairment through tight junction reduction. We measured expression of TLR/MyD88 signaling-related mRNAs and proteins. The indicator of intestinal barrier integrity was confirmed through immunofluorescence and transepithelial electrical resistance. Additionally, we confirmed whether inflammatory cytokines and barrier function were affected by MyD88 inhibition. MyD88 inhibition alleviated inflammatory cytokine levels, tight junction reduction, and damage to barrier function due to OTA. These results indicate that OTA induces TLR/MyD88 signaling-related genes and impairs tight junctions and intestinal barrier function in IPEC-J2 cells. MyD88 regulation in OTA-treated IPEC-J2 cells mitigates the tight junction and intestinal barrier function impairments. Our findings provide a molecular understanding of OTA toxicity in porcine intestinal epithelial cells. | Yoon, Jung Woong; Shin, Sangsu; Park, JeongWoong; Lee, Bo Ram; Lee, Sang In | Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; Kyungpook Natl Univ, Res Ctr Horse Ind, Sangju 37224, South Korea; Kyungpook Natl Univ, Dept Anim Biotechnol, Sangju 37224, South Korea; Rural Dev Adm, Natl Inst Anim Sci, Anim Biotechnol Div, Wonju 55365, South Korea | 58061240700; 55490360000; 58198744600; 56124581700; 57203597336 | mir88@korea.kr;silee78@knu.ac.kr; | TOXICS | TOXICS | 2305-6304 | 11 | 5 | SCIE | ENVIRONMENTAL SCIENCES;TOXICOLOGY | 2023 | 3.9 | 21.2 | 1.13 | 2025-06-25 | 8 | 7 | ochratoxin A; IPEC-J2 cells; TLR; MyD88 signaling; tight junction; intestinal barrier; inflammation | HEALTH; MYCOTOXIN; FOOD | inflammation; intestinal barrier; IPEC-J2 cells; ochratoxin A; tight junction; TLR/MyD88 signaling | alpha1 interferon; beta1 interferon; interferon regulatory factor 7; interleukin 1 receptor associated kinase 4; interleukin 6; mycotoxin; myeloid differentiation factor 88; ochratoxin; protein ZO1; toll like receptor; toll like receptor 1; toll like receptor 2; toll like receptor 3; toll like receptor 4; toll like receptor 5; toll like receptor 6; toll like receptor 7; toll like receptor 8; toll like receptor 9; tumor necrosis factor; tumor necrosis factor receptor associated factor 6; absorption; animal cell; animal experiment; animal model; Article; cell culture; controlled study; electric resistance; enteritis; immunofluorescence; inflammation; intestine epithelium; intestine epithelium cell; intestine function; IPEC-J2 cell line; mRNA expression level; nonhuman; signal transduction; tight junction; TLR signaling | English | 2023 | 2023-05-06 | 10.3390/toxics11050437 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Toxicokinetics and tissue distribution of phalloidin in mice | Phalloidin, a bicyclic heptapeptide found in Amanita mushroom, specifically binds to F-actin in the liver causing cholestatic hepatotoxicity. However, the toxicokinetics and tissue distribution properties of phalloidin as well as their underlying mechanisms have to be studied further. The area under the plasma concentration curve (AUC) of phalloidin increased in proportion to the doses (0.2, 0.4, and 0.8 mg/kg for intravenous injection and 2, 5, and 10 mg/kg for oral administration). Phalloidin exhibited dose-independent low volume of distribution (395.6-456.9 mL/kg) and clearance (21.4-25.5 mL/min/kg) and low oral bioavailability (2.4%-3.3%). This could be supported with its low absorptive permeability (0.23 +/- 0.05 x 10(-6) cm/s) in Caco-2 cells. The tissue-to-plasma AUC ratios of intravenously injected and orally administered phalloidin were the highest in the liver and intestines, respectively, and also high in the kidneys, suggesting that the liver, kidneys, and intestines could be susceptible to phalloidin exposure and that active transport via the hepatic and renal organic anion transporters (OATP1B1, OATP1B3, and OAT3) may contribute to the higher distribution of phalloidin in the liver and kidneys. | Lim, Chang Ho; Song, Im-Sook; Lee, Jihoon; Lee, Min Seo; Cho, Yong-Yeon; Lee, Joo Young; Kang, Han Chang; Lee, Hye Suk | Catholic Univ Korea, Coll Pharm, Bucheon 14662, South Korea; Catholic Univ Korea, BK21 Four Sponsored Adv Program SmartPharma Leader, Bucheon 14662, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Vessel Organ Interact Res Ctr VOICE,BK21 FOUR Comm, Daegu 41566, South Korea | Kang, Han/I-5999-2019; Cho, Yong-Yeon/AAD-4263-2020 | 57317155800; 7201564500; 57195979045; 57225079010; 55472207900; 57215684977; 36150873700; 35316111800 | maxlim8580@catholic.ac.kr;isssong@knu.ac.kr;legadema0905@knu.ac.kr;minseo.lee@catholic.ac.kr;yongyeon@catholic.ac.kr;joolee@catholic.ac.kr;hckang@catholic.ac.kr;sianalee@catholic.ac.kr; | FOOD AND CHEMICAL TOXICOLOGY | FOOD CHEM TOXICOL | 0278-6915 | 1873-6351 | 179 | SCIE | FOOD SCIENCE & TECHNOLOGY;TOXICOLOGY | 2023 | 3.9 | 21.2 | 0.3 | 2025-06-25 | 2 | 2 | Phalloidin; Toxicokinetics; Tissue distribution; Active transport; Oral absorption | MASS-SPECTROMETRY; CYCLOPEPTIDE TOXINS; INDUCED CHOLESTASIS; AMANITA-VIROSA; AMATOXINS; PHALLOTOXINS; TOXICITY; ACTIN; TRANSPORTERS; PREVENTION | Active transport; Oral absorption; Phalloidin; Tissue distribution; Toxicokinetics | Amanita; Animals; Caco-2 Cells; Humans; Mice; Phalloidine; Tissue Distribution; Toxicokinetics; organic anion transporter 3; phalloidin; solute carrier organic anion transporter 1B1; solute carrier organic anion transporter 1B3; phalloidin; absorption; active transport; animal cell; animal experiment; area under the plasma concentration curve; Article; bioavailability; Caco-2 cell line; cell membrane permeability; concentration response; controlled study; human; human cell; intestine tissue; kidney tissue; liver tissue; male; mass spectrometry; metabolic clearance; mouse; mushroom poisoning; nonhuman; tissue distribution; tissue specificity; toxicokinetics; transport kinetics; volume of distribution; Amanita; animal; tissue distribution; toxicokinetics | English | 2023 | 2023-09 | 10.1016/j.fct.2023.113994 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Real-world analysis of first-line afatinib in patients with EGFR-mutant non-small cell lung cancer and brain metastasis: survival and prognostic factors | Background: Overall survival (OS) in patients with non-small cell lung cancer (NSCLC) and brain metastases (BMs) is poor. We aimed to identify prognostic factors and ascertain treatment outcomes of firstline afatinib for patients with epidermal growth factor receptor (EGFR)-mutant NSCLC with BM in a realworld setting. Methods: This retrospective observational study reviewed electronic records of patients with EGFR-mutant NSCLC who received first-line afatinib treatment between October 2014 and October 2019 in 16 hospitals across South Korea. The Kaplan-Meier method estimated time on treatment (TOT) and OS; multivariate analyses were performed using Cox proportional hazards (PH) models. Results: Among 703 patients who received first-line afatinib, 262 (37.3%) had baseline BM. Of 441 patients without baseline BM, 92 (20.9%) developed central nervous system (CNS) failure. Compared with patients without CNS failure, those with CNS failure during afatinib treatment were younger (P=0.012), had a higher Eastern Cooperative Oncology Group (ECOG) performance status (PS) (P<0.001), increased metastatic site involvement (P<0.001), advanced stage disease (P<0.001), with liver metastasis (P=0.008) and/ or bone metastasis (P<0.001) at baseline. Cumulative incidence of CNS failure in years 1, 2 and 3 was 10.1%, 21.5% and 30.0%, respectively. In multivariate analysis, cumulative incidence was significantly higher in patients with ECOG PS =2 (P<0.001), uncommon EGFR mutations (P=0.001), and no baseline pleural metastasis (P=0.017). Median TOT was 16.0 months (95% CI: 14.8-17.2) and, in patients with CNS failure, without CNS failure, and with baseline BM was 12.2, 18.9, and 14.1 months, respectively (P<0.001). Median OS was 52.9 months (95% CI: 45.4-60.3) and, in patients with CNS failure, without CNS failure, and with baseline BM was 29.1, 67.3 and 48.5 months, respectively (P<0.001). Conclusions: First-line afatinib in the real-world setting showed clinically meaningful effectiveness in patients with EGFR-mutant NSCLC and BM. CNS failure was a poor prognostic factor for TOT and OS correlating with younger age, poor ECOG PS, higher metastatic number, advanced disease stage, uncommon EGFR mutations, and baseline liver and/or bone metastases. | Kim, Jehun; Jang, Tae Won; Choi, Chang Min; Kim, Mi Hyun; Lee, Sung Yong; Park, Cheol Kyu; Chang, Yoon Soo; Lee, Kye Young; Kim, Seung Joon; Yang, Sei Hoon; Ryu, Jeong Seon; Lee, Jeong Eun; Lee, Shin Yup; Park, Chan Kwon; Lee, Sang Hoon; Jang, Seung Hun; Yoon, Seong Hoon | Kosin Univ, Coll Med, Gospel Hosp, Dept Internal Med, 262 Gamcheon Ro, Busan 49267, South Korea; Ulsan Univ, Dept Internal Med, Asan Med Ctr, Seoul, South Korea; Pusan Natl Univ, Pusan Natl Univ Hosp, Dept Internal Med, Sch Med, Pusan, South Korea; Biomed Res Inst, Pusan, South Korea; Korea Univ, Div Pulmonol Allergy & Crit Care Med, Dept Internal Med, Guro Hosp, Seoul, South Korea; Chonnam Natl Univ, Dept Internal Med, Med Sch, Hwasun, Jeonnam, South Korea; Hwasun Hosp, Hwasun, Jeonnam, South Korea; Yonsei Univ, Dept Internal Med, Gangnam Severance Hosp, Seoul, South Korea; Konkuk Univ, Dept Internal Med, Med Ctr, Seoul, South Korea; Catholic Univ, Dept Internal Med, Seoul St Marys Hosp, Seoul, South Korea; Wonkwang Univ Hosp, Dept Internal Med, Iksan, South Korea; Inha Univ Hosp, Dept Internal Med, Incheon, South Korea; Chungnam Natl Univ, Dept Internal Med, Daejeon, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Catholic Univ, Dept Internal Med, Yeoudo St Marys Hosp, Seoul, South Korea; Yonsei Univ, Dept Internal Med, Severance Hosp, Seoul, South Korea; Hallym Univ, Dept Internal Med, Sacred Heart Hosp, Anyang, South Korea; Pusan Natl Univ, Dept Internal Med, Yangsan Hosp, Yangsan, South Korea | ; Park, Cheol-Kyu/AAT-9872-2021; Lee, Joo Yong/ADE-2110-2022; Lee, Sang-Hoon/ABH-6210-2020; Kim, Woo/A-8216-2019; Lee, Jeong Eun/R-8689-2019 | 57191899861; 7102426031; 14024046800; 26323727500; 56734650000; 57205721111; 58293916800; 8720534800; 57225930594; 7406950928; 7401868634; 57209104622; 49863712700; 14623269200; 57207065392; 7402219050; 55479240500 | jangtw22@hanmail.com; | TRANSLATIONAL LUNG CANCER RESEARCH | TRANSL LUNG CANCER R | 2218-6751 | 2226-4477 | 12 | 6 | SCIE | ONCOLOGY;RESPIRATORY SYSTEM | 2023 | 4 | 21.3 | 0.47 | 2025-06-25 | 3 | 3 | Afatinib; non-small cell lung cancer (NSCLC); brain metastasis (BM); EGFR mutation; tyrosine kinase inhibitor (TKI) | ASIAN PATIENTS; OPEN-LABEL; TARGETED THERAPY; NAIVE PATIENTS; RISK-FACTORS; MUTATION; GEFITINIB; EFFICACY; ADENOCARCINOMA; ERLOTINIB | Afatinib; brain metastasis (BM); EGFR mutation; non-small cell lung cancer (NSCLC); tyrosine kinase inhibitor (TKI) | afatinib; epidermal growth factor receptor; adult; advanced cancer; Article; bone metastasis; brain metastasis; cancer prognosis; cancer staging; cancer survival; central nervous system disease; central nervous system failure; controlled study; cumulative incidence; ECOG Performance Status; electronic medical record; exon; female; first-line treatment; gene mutation; human; Kaplan Meier method; liver metastasis; major clinical study; male; medical record review; multicenter study; non small cell lung cancer; observational study; overall survival; pleura metastasis; proportional hazards model; response evaluation criteria in solid tumors; retrospective study; South Korea; treatment outcome | English | 2023 | 2023-06 | 10.21037/tlcr-22-832 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Real-world first-line afatinib for advanced EGFR mutation-positive non-small cell lung cancer in Korea: updated survival data | Background: Data from clinical trials and real-world studies show that afatinib is effective in treating non-small cell lung cancer (NSCLC) harboring activating mutations in the epidermal growth factor receptor (EGFR) gene. A previous analysis of patients enrolled in the Korean Academy of Tuberculosis and Respiratory Disease (KATRD) EGFR cohort showed that first-line afatinib was well tolerated and effectiveness results were encouraging. At the time of the previous analysis, survival data were not mature. Here we briefly present updated survival data from the cohort.Methods: The study was a retrospective, multicenter (15 sites) review of electronic records of Korean adult patients (aged >20 years) with advanced EGFR mutation-positive NSCLC who initiated first-line afatinib (N=421). Progression-free survival (PFS) and overall survival (OS) were evaluated using Kaplan-Meier survival curves.Results: Overall, median PFS was 20.2 months and median OS was 48.6 months. OS rates at 36 and 60 months were 60.1% and 42.3%, respectively. Presence vs. absence of baseline brain metastases was associated with significantly reduced median PFS (14.9 vs. 28.6 months; P= 70 years).Conclusions: Afatinib was effective in Korean patients with EGFR mutation-positive NSCLC with median OS over 4 years. The presence of baseline brain metastases and/or uncommon EGFR mutations were associated with reduced survival. In the absence of baseline brain metastases, median OS was more than 5 years. | Choi, Juwhan; Choi, Chang Min; Chang, Yoon Soo; Lee, Kye Young; Kim, Seung Joon; Yang, Sei Hoon; Ryu, Jeong Seon; Lee, Jeong Eun; Lee, Shin Yup; Park, Ji Young; Kim, Young-Chul; Oh, In-Jae; Jung, Chi Young; Lee, Sang Hoon; Yoon, Seong Hoon; Lee, Sung Yong; Jang, Tae Won | Korea Univ, Guro Hosp, Dept Internal Med, Div Pulm, Seoul, South Korea; Ulsan Univ, Crit Care Med, Asan Med Ctr, Asan Med Ctr, Seoul, South Korea; Yonsei Univ, Gangnam Severance Hosp, Div Pulm, Dept Internal Med, Seoul, South Korea; Konkuk Univ, Med Ctr, Precis Med Lung Canc Ctr, Seoul, South Korea; Catholic Univ, Seoul St Marys Hosp, Dept Internal Med, Div Pulm, Catholic Univ Seoul St, Seoul, South Korea; Wonkwang Univ Hosp, Dept Internal Med, Div Pulm & Crit Care Med, Iksan, South Korea; Inha Univ Hosp, Dept Internal Med, Div Pulm, Div Pulmonol,Sch Med, Incheon, South Korea; Chungnam Natl Univ Hosp, Dept Internal Med, Div Pulm, Daejeon, South Korea; Kyungpook Natl Univ, Dept Internal Med, Div Pulm, Daegu, South Korea; Hallym Univ, Sacred Heart Hosp, Div Pulm Allergy & Crit Med, Dept Internal Med, Anyang, South Korea; Hwasun Hosp, Hwasun, South Korea; Chonnam Natl Univ, Med Sch, Dept Internal Med, Hwasun, South Korea; Daegu Catholic Univ, Dept Internal Med, Div Pulm, Med Ctr, Daegu, South Korea; Yonsei Univ, Kangnam Severance Hosp, Coll Med, Dept Internal Med,Div Pulm, Seoul, South Korea; Pusan Natl Univ, Yangsan Hosp, Div Pulm, Dept Internal Med, Yangsan, South Korea; Kosin Univ Gospel Hosp, Dept Internal Med, Div Pulm, Div Gastroenterol, Pusan, South Korea; Kosin Univ Gospel Hosp, Gospel Hosp, Dept Internal Med, Div Pulm, 262 Gamchenro, Pusan 49267, South Korea | Oh, In-Jae/AAG-5919-2020; Lee, Joo Yong/ADE-2110-2022; Lee, Jeong Eun/R-8689-2019; Park, Jin-Young/HDN-0483-2022; Lee, Sang-Hoon/ABH-6210-2020; Kim, Yong-Joo/AAK-1840-2021 | 57193228530; 14024046800; 58293916800; 8720534800; 57225930594; 7406950928; 7401868634; 57209104622; 49863712700; 57193095178; 35201246200; 58754601500; 57223991305; 57207065392; 55479240500; 56734650000; 7102426031 | jangtw22@hanmail.net; | TRANSLATIONAL LUNG CANCER RESEARCH | TRANSL LUNG CANCER R | 2218-6751 | 2226-4477 | 12 | 11 | SCIE | ONCOLOGY;RESPIRATORY SYSTEM | 2023 | 4 | 21.3 | 0.16 | 2025-06-25 | 1 | 1 | Afatinib; epidermal growth factor receptor (EGFR); first-line; non-small cell lung cancer (NSCLC); real-world | ASIAN PATIENTS; OPEN-LABEL; ADENOCARCINOMA | Afatinib; epidermal growth factor receptor (EGFR); first-line; non-small cell lung cancer (NSCLC); real-world | afatinib; epidermal growth factor receptor; adult; advanced cancer; aged; Article; brain metastasis; cancer survival; cohort analysis; controlled study; drug dose reduction; exon; gene mutation; human; Kaplan Meier method; Korea; non small cell lung cancer; overall response rate; overall survival; progression free survival; retrospective study | English | 2023 | 2023-11 | 10.21037/tlcr-23-383 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | D-dimer to fibrinogen ratio predicts early neurological deterioration in ischemic stroke with atrial fibrillation | Introduction: The D-dimer to fibrinogen ratio (DFR) is a good indicator of clot-producing activity in thrombotic disease, but its clinical usefulness in stroke patients with nonvalvular atrial fibrillation (NVAF) has not been studied. We evaluated the association between the DFR and early neurological deterioration (END) in acute ischemic stroke (AIS) patients with NVAF.Methods: We included consecutive AIS patients with NVAF between 2013 and 2015 from the registry of a realworld prospective cohort from 11 large centers in South Korea. END was defined as an increase =2 in the total NIHSS score or = 1 in the motor NIHSS score within the first 72 h of admission. The DFR was calculated as follows: DFR = D-dimer (mg/L)/fibrinogen (mg/dL) x 100.Results: A total of 1018 AIS patients with NVAF were evaluated. In multivariable logistic regression analysis, the highest DFR tertile was closely associated with END (adjusted odds ratio [aOR] = 2.14, 95 % confidence interval [CI]: 1.24-3.69). Hypertension (aOR = 1.71, 95 % CI: 1.09-2.70), initial NIHSS score (aOR = 1.05, 95 % CI: 1.02-1.07) and use of anticoagulants (aOR = 0.41, 95 % CI: 0.28-0.60) were also correlated with END. In addition to END, the DFR was correlated with discharge NIHSS and modified Rankin Scale (mRS) scores and the 3-month mRS score.Conclusions: High DFR values were associated with END in AIS patients with NVAF. As the DFR is an indicator directly related to the main pathological mechanism of NVAF patients (fibrinolysis and coagulation), it may be useful in predicting their prognosis. | Nam, Ki-Woong; Kim, Chi Kyung; Yu, Sungwook; Oh, Kyungmi; Chung, Jong-Won; Bang, Oh. Young; Kim, Gyeong-Moon; Jung, Jin-Man; Song, Tae-Jin; Kim, Yong-Jae; Kim, Bum Joon; Heo, Sung Hyuk; Park, Kwang-Yeol; Kim, Jeong-Min; Park, Jong-Ho; Choi, Jay Chol; Park, Man-Seok; Kim, Joon-Tae; Choi, Kang-Ho; Ha Hwang, Yang; Seo, Woo-Keun | Seoul Natl Univ, Dept Neurol, Boramae Med Ctr, Seoul Metropolitan Govt, Seoul, South Korea; Korea Univ, Korea Univ Guro Hosp, Dept Neurol, Coll Med, Seoul, South Korea; Korea Univ, Korea Univ Anam Hosp, Dept Neurol, Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Neurol, Sch Med, Seoul, South Korea; Korea Univ, Ansan Hosp, Coll Med, Dept Neurol, Ansan, South Korea; Ewha Womans Univ, Sch Med, Dept Neurol, Seoul, South Korea; Catholic Univ Korea, Dept Neurol, Seoul, South Korea; Asan Med Ctr, Dept Neurol, Seoul, South Korea; Kyung Hee Univ, Coll Med, Dept Neurol, Seoul, South Korea; Chung Ang Univ, Chung Ang Univ Hosp, Dept Neurol, Coll Med, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Neurol, Seoul, South Korea; Hanyang Univ, Myongji Hosp, Dept Neurol, Coll Med, Seoul, South Korea; Jeju Natl Univ, Dept Neurol, Jeju, South Korea; Chonnam Natl Univ Hosp, Dept Neurol, Chungnam, South Korea; Kyungpook Natl Univ Hosp, Dept Neurol, Daegu, South Korea; Sungkyunkwan Univ, Dept Digital Hlth, SHAIST, Seoul, South Korea; Korea Univ, Coll Med, Dept Neurol, Guro Hosp, 148 Gurodong Ro,Guro Gu, Seoul 08308, South Korea | Kim, Chi/AAR-9819-2020; Kim, Jeong-Min/ABH-2469-2021; Jung, Jin-Man/LJL-8037-2024; choi, jo/O-5940-2014; Heo, Sung/P-3529-2019; Kim, Jinkwon/AAR-6729-2021; Kim, Yong-Jae/JQW-5758-2023; Choi, Kangho/HKV-1503-2023 | 57189377536; 56701057800; 56144716300; 16048029600; 55553751200; 7006620221; 35237139600; 15755814800; 55507164200; 55865497600; 57214661365; 18835720200; 36060099300; 7601375827; 57390600900; 7501392645; 7404490852; 23667663000; 36491173100; 7402311308; 22981667600 | ckkim7@korea.ac.kr; | THROMBOSIS RESEARCH | THROMB RES | 0049-3848 | 1879-2472 | 229 | SCIE | HEMATOLOGY;PERIPHERAL VASCULAR DISEASE | 2023 | 3.7 | 21.4 | 0.44 | 2025-06-25 | 5 | 3 | Ischemic stroke; D-dimer; Coagulopathy; Fibrinolysis; Prognosis | D-DIMER/FIBRINOGEN RATIO; PULMONARY-EMBOLISM; THROMBUS | Coagulopathy; D-dimer; Fibrinolysis; Ischemic stroke; Prognosis | Atrial Fibrillation; Brain Ischemia; Fibrinogen; Humans; Ischemic Stroke; Prospective Studies; Risk Factors; Stroke; anticoagulant agent; C reactive protein; D dimer; fibrinogen; fibrin fragment D; fibrinogen; aged; Article; atrial fibrillation; body mass; controlled study; D dimer to fibrinogen ratio; deterioration; disease duration; drug use; dyslipidemia; female; human; hypertension; ischemic stroke; logistic regression analysis; major clinical study; male; medical history; medical parameters; multivariate logistic regression analysis; National Institutes of Health Stroke Scale; Rankin scale; scoring system; systolic blood pressure; very elderly; brain ischemia; cerebrovascular accident; complication; prospective study; risk factor | English | 2023 | 2023-09 | 10.1016/j.thromres.2023.07.014 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Defining Structural Cracks in Exterior Walls of Concrete Buildings Using an Unmanned Aerial Vehicle | In Republic of Korea, cracks in concrete structures are considered to be objective structural defects, and the constant maintenance of deteriorating facilities leads to substantial social costs. Thus, it is important to develop technologies that enable economical and efficient building safety inspection. Recently, the application of UAVs and deep learning is attracting attention for efficient safety inspection. However, the currently developed technology has limitations in defining structural cracks that can seriously affect the stability of buildings. This study proposes a method to define structural cracks on the outer wall of a concrete building by merging the orthoimage layer and the structural drawing layer with the UAV and deep learning that were previously applied during a safety inspection. First, we acquired data from UAV-based aerial photography and detected cracks through deep learning. Structural and non-structural cracks were defined using detected crack layer, design drawing layer defined the structural part, and the orthoimage layer was based on UAV images. According to the analysis results, 116 structural parts cracks and 149 non-structural parts cracks were defined out of a total of 265 cracks. In the future, the proposed method is expected to greatly contribute to safety inspections by being able to determine the quality and risk of cracks. | Woo, Hyun-Jung; Hong, Won-Hwa; Oh, Jintak; Baek, Seung-Chan | Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy Engn, Daegu 41566, South Korea; Kyungil Univ, Dept Architecture, Gyongsan 38428, South Korea | 57219244497; 7401527968; 55977660300; 56909374400 | baeksc@kiu.kr; | DRONES | DRONES-BASEL | 2504-446X | 7 | 3 | SCIE | REMOTE SENSING | 2023 | 4.4 | 21.4 | 1.33 | 2025-06-25 | 7 | 11 | unmanned aerial vehicles; aerial photography; structural cracks; concrete buildings | UAV | aerial photography; concrete buildings; structural cracks; unmanned aerial vehicles | Concrete buildings; Concretes; Medical imaging; Photographic equipment; Unmanned aerial vehicles (UAV); Walls (structural partitions); Aerial vehicle; Exterior walls; Non-structural; Orthoimages; Republic of Korea; Safety inspections; Structural crack; Structural defect; Structural parts; Unmanned aerial vehicle; Aerial photography | English | 2023 | 2023-03 | 10.3390/drones7030149 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Energy Minimization in Reconfigurable Intelligent Surface-Assisted Unmanned Aerial Vehicle-Enabled Wireless Powered Mobile Edge Computing Systems with Rate-Splitting Multiple Access | In this study, a reconfigurable intelligent surface (RIS)-assisted wireless-powered mobile edge computing (WP-MEC) system is proposed, where a single-antenna unmanned aerial vehicle (UAV)-mounted cloudlet provides offloading opportunities to K user equipments (UEs) with a single antenna, and the K UEs can harvest the energy from the broadcast radio-frequency signals of the UAV. In addition, rate-splitting multiple access is used to provide offloading opportunities to multiple UEs for effective power control and high spectral efficiency. The aim of this paper is to minimize the total energy consumption by jointly optimizing the resource allocation in terms of time, power, computing frequency, and task load, along with the UAV trajectory and RIS phase-shift matrix. Since coupling issues between optimization variable designs are caused, however, an alternating optimization-based algorithm is developed. The performance of the proposed algorithm is verified via simulations and compared with the benchmark schemes of partial optimizations of resource allocation, path planning, and RIS phase design. The proposed algorithm exhibits high performance in WP-MEC systems with insufficient resources, e.g., achieving up to 40% energy reduction for a UAV with eight elements of RIS. | Kim, Jihyung; Hong, Eunhye; Jung, Jaemin; Kang, Jinkyu; Jeong, Seongah | Elect & Telecommun Res Inst, Spatial Wireless Transmiss Res Sect, Daejeon 34129, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea; Myongji Univ, Dept Informat & Commun Engn, Yongin 17058, South Korea | Kang, Joonhyuk/C-1771-2011; Jeong, Seongah/I-2863-2017; Jeong, Seongah/ABW-7285-2022; Jung, Jaemin/C-2064-2011 | 55862546900; 58773061600; 57842231600; 56283062100; 55210226900 | savant21@etri.re.kr;ghddms21@knu.ac.kr;jjm91548971@mju.ac.kr;jkkang@mju.ac.kr;seongah@knu.ac.kr; | DRONES | DRONES-BASEL | 2504-446X | 7 | 12 | SCIE | REMOTE SENSING | 2023 | 4.4 | 21.4 | 0.48 | 2025-06-25 | 4 | 4 | mobile edge computing; wireless energy transfer; reconfigurable intelligent surfaces; offloading; unmanned aerial vehicle; rate-splitting multiple access | OPTIMIZATION | mobile edge computing; offloading; rate-splitting multiple access; reconfigurable intelligent surfaces; unmanned aerial vehicle; wireless energy transfer | Benchmarking; Broadcasting antennas; Conformal mapping; Energy utilization; Inductive power transmission; Interlocking signals; Linear programming; Mobile antennas; Motion planning; Power management (telecommunication); Smart antennas; Unmanned aerial vehicles (UAV); Unmanned surface vehicles; Aerial vehicle; Edge computing; Multiple access; Offloading; Rate splitting; Rate-splitting multiple access; Reconfigurable; Reconfigurable intelligent surface; Unmanned aerial vehicle; Wireless energy transfers; Resource allocation | English | 2023 | 2023-12 | 10.3390/drones7120688 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | FANET Routing Protocol Analysis for Multi-UAV-Based Reconnaissance Mobility Models | Different from mobile ad hoc networks (MANETs) and vehicular ad hoc networks (VANETs), a flying ad hoc network (FANET) is a very low-density network where node topology changes rapidly and irregularly. These characteristics, the density, mobility, and speed of flight nodes, affect the performance of FANET. Furthermore, application scenarios and environmental settings could affect the performance of FANETs. In this paper, we analyzed the representative FANET protocols, AODV, DSDV, and OLSR, according to mobility models, SRWP, MP, RDPZ, EGM, and DPR, under the multi-UAV-based reconnaissance scenario. We evaluated them in terms of the number of nodes, network connectivity, mobility model's reconnaissance rate, speed of nodes, and ground control station (GCS) location. As a result, we found that AODV showed the highest PDR performance (81%) with SRWP in multiple UAV-based reconnaissance scenarios. As for a mobility model under the consideration of reconnaissance rate, SRWP was excellent at 76%, and RDPZ and EGM mobility models were reasonable at 62% and 60%, respectively. We also made several interesting observations such as how when the number of nodes increases, the connectivity of the network increases, but the performance of the routing protocol decreases, and how the GCS location affects the PDR performance of the combination of routing protocols and mobility models. | Kim, Taehwan; Lee, Seonah; Kim, Kyong Hoon; Jo, Yong-Il | Gyeongsang Natl Univ, Dept AI Convergence Engn, 501 Jinjudaero, Jinju Si 52828, South Korea; Gyeongsang Natl Univ, Dept Aerosp & Software Engn, 501 Jinjudaero, Jinju Si 52828, South Korea; Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea | ; Kim, Honghyok/LDF-5356-2024 | 58171979700; 25822639700; 15065463500; 57211049631 | saleese@gnu.ac.kr;kyong.kim@knu.ac.kr; | DRONES | DRONES-BASEL | 2504-446X | 7 | 3 | SCIE | REMOTE SENSING | 2023 | 4.4 | 21.4 | 4.34 | 2025-06-25 | 21 | 36 | FANET; routing protocol; NS-3; multi-UAVs; reconnaissance; mobility models | AD HOC NETWORKS | FANET; mobility models; multi-UAVs; NS-3; reconnaissance; routing protocol | Mobile telecommunication systems; Reconnaissance aircraft; Unmanned aerial vehicles (UAV); VTOL/STOL aircraft; Ad-hoc networks; Flying ad hoc network; Ground-control stations; Mobility modeling; Multi UAV; NS-3; Performance; Reconnaissance; Routing-protocol; Station location; Vehicular ad hoc networks | English | 2023 | 2023-03 | 10.3390/drones7030161 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Impact of Atrial Fibrillation on Patients Undergoing Transcatheter Aortic Valve Implantation (TAVI): The K-TAVI Registry | Purpose: The incidence and prognostic implications of atrial fibrillation (AF) in patients with severe aortic stenosis (AS) undergo-ing transcatheter aortic valve implantation (TAVI) are controversial, especially for Korean patients. Furthermore, the pattern of an-tithrombotic therapy for these patients is unknown. The present study sought to identify the impact of AF on Korean patients un-dergoing TAVI and demonstrate the status of antithrombotic therapy for these patients.Materials and Methods: A total of 660 patients who underwent TAVI for severe AS were recruited from the nationwide K-TAVI registry in Korea. The enrolled patients were stratified into sinus rhythm (SR) and AF groups. The primary endpoint was all-cause death at 1-year.Results: AF was recorded in 135 patients [pre-existing AF 108 (16.4%) and new-onset AF 27 (4.1%)]. The rate of all-cause death at 1 year was significantly higher in patients with AF than in those with SR [16.2% vs. 6.4%, adjusted hazard ratio (HR): 2.207, 95% con-fidence interval (CI): 1.182-4.120, p=0.013], regardless of the onset timing of AF. The rate of new pacemaker insertion at 1 year was also significantly higher in patients with AF than in those with SR (14.0% vs. 5.5%, adjusted HR: 3.137, 95%CI: 1.621-6.071, p=0.001). Among AF patients, substantial number of patients received the combination of multiple antithrombotic agents (77.8%), and the most common combination was that of aspirin and clopidogrel (38.1%).Conclusion: AF was an independent predictor of 1-year mortality and new pacemaker insertion in Korean patients undergoing TAVI. | Lee, Sang Yoon; Choi, Ki Hong; Park, Taek Kyu; Kim, Jihoon; Kim, Eun Kyoung; Park, Sung-Ji; Park, Seung Woo; Gwon, Hyeon-Cheol; Chang, Kiyuk; Yu, Cheol Woong; Kim, JuHan; Choi, Young Jin; Chae, In-Ho; Lee, Jae-Hwan; Kim, Jun-Hong; Park, Jong Seon; Kim, Won-Jang; Yoon, Young Won; Ahn, Tae Hoon; Lee, Sang Rok; Choi, Byoung Joo; Yang, Tae-Hyun; Choi, Cheol Ung; Hur, Seung-Ho; Oh, Seong-Jin; Lee, Han Cheol; Park, HunSik; Kim, Hyo-Soo; Choi, Seung-Hyuk | Sungkyunkwan Univ Sch Med, Heart Vasc Stroke Inst, Div Cardiol, Dept Internal Med,Samsung Med Ctr, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Div Cardiol, Dept Internal Med, Seoul, South Korea; Korea Univ, Div Cardiol, Dept Internal Med, Cardiovasc Ctr,Anam Hosp, Seoul, South Korea; Heart Ctr Chonnam Natl Univ Hosp, Gwangju, South Korea; Sejong Gen Hosp, Cardiovasc Ctr, Cardiol, Bucheon, South Korea; Seoul Natl Univ, Div Cardiol, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; Chungnam Natl Univ, Sch Med, Dept Cardiol, Chungnam Natl Univ Hosp, Daejeon, South Korea; Pusan Natl Univ, Div Cardiol, Dept Internal Med, Yangsan Hosp, Busan, South Korea; Pusan Natl Univ, Res Inst Convergence Biomed Sci & Technol, Yangsan Hosp, Busan, South Korea; Yeungnam Univ Hosp, Dept Med, Daegu, South Korea; CHA Univ, CHA Bundang Med Ctr, Dept Cardiol, Seongnam, South Korea; Yonsei Univ, Gangnam Severance Hosp, Heart Ctr, Div Cardiol,Coll Med, Seoul, South Korea; Gachon Univ, Cardiol, Gil Med Ctr, Incheon, South Korea; Chonbuk Natl Univ Hosp, Dept Internal Med, Div Cardiol, Jeonju, South Korea; Ajou Univ, Dept Cardiol, Med Ctr, Suwon, South Korea; Univ Inje, Busan Paik Hosp, Dept Cardiol, Coll Med, Busan, South Korea; Korea Univ, Coll Med, Div Cardiol, Dept Internal Med,Guro Hosp,Cardiovasc Ctr, Seoul, South Korea; Keimyung Univ, Dept Internal Med, Dongsan Med Ctr, Daegu, South Korea; Ilsan Hosp, Div Cardiol, Natl Hlth Insurance Serv, Goyang, South Korea; Pusan Natl Univ Hosp, Dept Cardiol, Busan, South Korea; Pusan Natl Univ Hosp, Med Res, Busan, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Seoul Natl Univ Hosp, Cardiol Ctr, Dept Internal Med, Seoul, South Korea | ; Lee, Jung-Hye/F-6974-2013; Choi, So/AAV-1947-2020; Chae, In-Ho/J-5682-2012; Han, Jae-Young/AAV-1100-2021; Park, Seung/C-6989-2011; Cho, Young-Seok/J-5670-2012; Kim, Hyo/J-2753-2012 | 57904806300; 55756735500; 55750570800; 55757727000; 55705505300; 36017243100; 55176620800; 6603262426; 25521288100; 54586299100; 57196169644; 57361316200; 35274374100; 36066387900; 58394396400; 57202138283; 37070117400; 7402126578; 57222278496; 55887032200; 59287758300; 57203376310; 15046409800; 34570274500; 57445871900; 56502715100; 57198844106; 33567809200; 57213560615 | sh1214.choi@samsung.com; | YONSEI MEDICAL JOURNAL | YONSEI MED J | 0513-5796 | 1976-2437 | 64 | 7 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 2.6 | 21.4 | 1.54 | 2025-06-25 | 6 | 6 | Transcatheter aortic valve implantation; atrial fibrillation; Korean; antithrombotic agent | PERMANENT PACEMAKER IMPLANTATION; PREDICTIVE FACTORS; PROGNOSTIC VALUE; REPLACEMENT; OUTCOMES; STENOSIS; SOCIETY | antithrombotic agent; atrial fibrillation; Korean; Transcatheter aortic valve implantation | Aortic Valve; Aortic Valve Stenosis; Atrial Fibrillation; Fibrinolytic Agents; Humans; Prognosis; Registries; Risk Factors; Transcatheter Aortic Valve Replacement; Treatment Outcome; acetylsalicylic acid; anticoagulant agent; antivitamin K; cilostazol; clopidogrel; creatinine; warfarin; fibrinolytic agent; aged; all cause mortality; anticoagulant therapy; aortic valve replacement; Article; atrial fibrillation; bleeding; body mass; brain hemorrhage; brain ischemia; cardiovascular risk; cerebrovascular accident; CHA2DS2-VASc score; chronic obstructive lung disease; clinical outcome; coronary artery bypass graft; coronary artery disease; diabetes mellitus; dual antiplatelet therapy; echocardiography; electrocardiography; female; follow up; heart atrium flutter; heart infarction; heart left bundle branch block; heart left ventricle ejection fraction; heart right bundle branch block; hematocrit; hemodynamics; human; hypertension; major clinical study; male; mitral valve regurgitation; mortality; observational study; percutaneous coronary intervention; peripheral arterial disease; renal replacement therapy; retrospective study; risk factor; sinus rhythm; smoking; Society of Thoracic Surgeons score; systolic blood pressure; telemetry; transcatheter aortic valve implantation; aortic valve; aortic valve stenosis; atrial fibrillation; complication; prognosis; register; treatment outcome | English | 2023 | 2023-07 | 10.3349/ymj.2022.0649 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Implementation of Prognostic Cloud Ice Number Concentrations for the Weather Research and Forecasting (WRF) Double-Moment 6-Class (WDM6) Microphysics Scheme | The ice microphysical processes in the Weather Research and Forecasting (WRF) Double-Moment 6-class (WDM6) microphysics scheme are treated as a single-moment approach, in which the number concentration of cloud ice is diagnosed based on its mixing ratio. This study develops the revised WDM6 scheme through the implementation of prognostic cloud ice number concentrations. The effect of the prognostic number concentration on the simulated precipitation is verified through simulations of short-term winter snowfall cases during International Collaborative Experiments for the Pyeongchang 2018 Olympics and Paralympics (ICE-POP 2018) winter games and a 1-month regional climate case during the summer season, July 2009. For all cases, the revised WDM6 simulates higher cloud ice number concentrations and lower cloud ice mixing ratios than the original WDM6. The microphysics budget analysis for the snowfall cases shows that the inefficient deposition and vapor freezing nucleation processes of cloud ice reduce the available cloud ice mixing ratio. Consequently, the accretion processes with cloud ice decrease and the deposition into snow increases due to the surplus water vapor. The revised WDM6 alleviates the positive bias of surface precipitation consisting of snow over the region where the original WDM6 simulates excessive precipitation, compared to the observed data. For the regional climate case, the reduced cloud ice amount strengthens the Western North Pacific high-pressure system by allowing more solar radiation to reach the surface, leading to simulated precipitation bands and synoptic environments that are more comparable with the observed data. | Park, Sun-Young; Lim, Kyo-Sun Sunny | Kyungpook Natl Univ, Sch Earth Syst Sci, Ctr Atmospher Remote Sensing CARE, Dept Atmospher Sci, Daegu, South Korea | Lim, Kyo-Sun/I-3811-2012; Park, Sun/ABB-2937-2021 | 58111297900; 57211926026 | kyosunlim@knu.ac.kr; | JOURNAL OF ADVANCES IN MODELING EARTH SYSTEMS | J ADV MODEL EARTH SY | 1942-2466 | 15 | 2 | SCIE | METEOROLOGY & ATMOSPHERIC SCIENCES | 2023 | 4.4 | 21.4 | 0.61 | 2025-06-25 | 5 | 5 | WDM6; WRF; cloud ice; number concentration; ICE-POP 2018; regional climate | BULK PARAMETERIZATION; PART II; WINTER STORMS; MODEL; SNOW; CIRRUS; IMPACT; FIELD; DISTRIBUTIONS; SIMULATIONS | cloud ice; ICE-POP 2018; number concentration; regional climate; WDM6; WRF | Kangwon; Pacific Ocean; Pacific Ocean (North); Pyeongchang; South Korea; Budget control; Deposition; Earth system models; Mixing; Snow; Weather forecasting; (WRF) double-moment 6-class; Cloud ice; International collaborative experiment for the pyeongchang 2018 olympic and paralympic; Microphysics; Mixing ratios; Number concentration; Observed data; Olympics; Regional climate; Weather research and forecasting; atmospheric chemistry; cloud microphysics; concentration (composition); ice; precipitation (climatology); regional climate; solar radiation; weather forecasting; Ice | English | 2023 | 2023-02 | 10.1029/2022ms003009 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Mathematical Modeling of COVID-19 Transmission and Intervention in South Korea: A Review of Literature | South Korea implemented interventions to curb the spread of the novel coronavirus disease 2019 (COVID-19) pandemic with discovery of the first case in early 2020. Mathematical modeling designed to reflect the dynamics of disease transmission has been shown to be an important tool for responding to COVID-19. This study aimed to review publications on the structure, method, and role of mathematical models focusing on COVID-19 transmission dynamics in Korea. In total, 42 papers published between August 7, 2020 and August 21, 2022 were studied and reviewed. This study highlights the construction and utilization of mathematical models to help craft strategies for predicting the course of an epidemic and evaluating the effectiveness of control strategies. Despite the limitations caused by a lack of available epidemiological and surveillance data, modeling studies could contribute to providing scientific evidence for policymaking by simulating various scenarios. | Lee, Hyojung; Kim, Sol; Jeong, Minyoung; Choi, Eunseo; Ahn, Hyeonjeong; Lee, Jeehyun | Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Yonsei Univ, Sch Math & Comp Math, 50 Yonsei Ro, Seoul 03722, South Korea | Choi, Eunseo/AAI-4243-2020; Kim, Seong/AAV-1869-2020 | 57196021198; 59631040600; 58029453200; 58029453300; 58029969000; 16745337100 | ezhyun@yonsei.ac.kr; | YONSEI MEDICAL JOURNAL | YONSEI MED J | 0513-5796 | 1976-2437 | 64 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 2.6 | 21.4 | 0.61 | 2025-06-25 | 5 | 5 | COVID-19; mathematical modeling; transmission dynamics; intervention; South Korea | DYNAMICS; OUTBREAK | COVID-19; intervention; mathematical modeling; South Korea; transmission dynamics | COVID-19; Humans; Models, Theoretical; Pandemics; Republic of Korea; SARS-CoV-2; basic reproduction number; compartment model; contact examination; coronavirus disease 2019; disease transmission; epidemic; hospitalization; human; incidence; mathematical model; mortality rate; Review; social distancing; stochastic model; susceptible exposed infectious recovered model; vaccination; epidemiology; pandemic; South Korea; theoretical model | English | 2023 | 2023-01 | 10.3349/ymj.2022.0471 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Secrecy Energy Efficiency Maximization for Secure Unmanned-Aerial-Vehicle-Assisted Simultaneous Wireless Information and Power Transfer Systems | Unmanned aerial vehicle (UAV)-assisted simultaneous wireless information and power transfer (SWIPT) systems have recently gained significant attraction in internet-of-things (IoT) applications that have limited or no infrastructure. Specifically, the free mobility of UAVs in three-dimensional (3D) space allows us good-quality channel links, thereby enhancing the communication environment and improving performance in terms of achievable rates, latency, and energy efficiency. Meanwhile, IoT devices can extend their battery life by harvesting the energy following the SWIPT protocol, which leads to an increase in the overall system lifespan. In this paper, we propose a secure UAV-assisted SWIPT system designed to optimize the secrecy energy efficiency (SEE) of a ground network, wherein a base station (BS) transmits confidential messages to an energy-constrained device in the presence of a passive eavesdropper. Here, we employ a UAV acting as a helper node to improve the SEE of the system and to aid in the energy harvesting (EH) of the battery-limited ground device following the SWIPT protocol. To this end, we formulate the SEE maximization problem by jointly optimizing the transmit powers of the BS and UAV, the power-splitting ratio for EH operations, and the UAV's flight path. The solution is obtained via a proposed algorithm that leverages successive convex approximation (SCA) and Dinkelbach's method. Through simulations, we corroborate the feasibility and effectiveness of the proposed algorithm compared to conventional partial optimization approaches. | Ha, Daehan; Jeong, Seongah; Kang, Jinkyu; Kang, Joonhyuk | Korea Adv Inst Sci & Technol KAIST, Sch Elect Engn, Daejeon 34141, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 14566, South Korea; Myongji Univ, Dept Informat & Commun Engn, Yongin 17058, South Korea | Jeong, Seongah/I-2863-2017; Kang, Joonhyuk/C-1771-2011; Jeong, Seongah/ABW-7285-2022 | 55551455300; 55210226900; 56283062100; 7404517651 | daehan.ha@kaist.ac.kr;seongah@knu.ac.kr;jkkang@mju.ac.kr;jhkang@ee.kaist.ac.kr; | DRONES | DRONES-BASEL | 2504-446X | 7 | 11 | SCIE | REMOTE SENSING | 2023 | 4.4 | 21.4 | 0.24 | 2025-06-25 | 2 | 2 | unmanned aerial vehicle (UAV); physical-layer security (PLS); secrecy energy efficiency (SEE); simultaneous wireless information and power transfer (SWIPT) | UAV; COMMUNICATION; DESIGN; SWIPT | physical-layer security (PLS); secrecy energy efficiency (SEE); simultaneous wireless information and power transfer (SWIPT); unmanned aerial vehicle (UAV) | Aircraft communication; Antenna grounds; Convex optimization; Dynamic programming; Inductive power transmission; Linear programming; Medium access control; Nuclear batteries; Unmanned aerial vehicles (UAV); Aerial vehicle; Efficiency maximization; Energy; Information and power transfers; Physical layer security; Physical-layer security; Power transfer systems; Secrecy energy efficiency; Simultaneous wireless information and power transfer; Unmanned aerial vehicle; Energy transfer | English | 2023 | 2023-11 | 10.3390/drones7110672 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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