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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Automated Screening of Precancerous Cervical Cells Through Contrastive Self-Supervised Learning | Cervical cancer is a significant health challenge, yet it can be effectively prevented through early detection. Cytology-based screening is critical for identifying cancerous and precancerous lesions; however, the process is labor-intensive and reliant on trained experts to scan through hundreds of thousands of mostly normal cells. To address these challenges, we propose a novel distribution-augmented approach using contrastive self-supervised learning for detecting abnormal squamous cervical cells from cytological images. Our method utilizes color augmentations to enhance the model's ability to differentiate between normal and high-grade precancerous cells; specifically, high-grade squamous intraepithelial lesions (HSILs) and atypical squamous cells-cannot exclude HSIL (ASC-H). Our model was trained exclusively on normal cervical cell images and achieved high diagnostic accuracy, demonstrating robustness against color distribution shifts. We employed kernel density estimation (KDE) to assess cell type distributions, further facilitating the identification of abnormalities. Our results indicate that our approach improves screening accuracy and reduces the workload for cytopathologists, contributing to more efficient cervical cancer screening programs. | Chun, Jaewoo; Yu, Ando; Ko, Seokhwan; Chong, Gunoh; Park, Jiyoung; Han, Hyungsoo; Park, Nora Jeeyoung; Cho, Junghwan | Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, Daegu 41944, South Korea; Kyungpook Natl Univ, Clin Omics Inst, Daegu 41405, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Obstet & Gynecol, Daegu 41404, South Korea; Kyungpook Natl Univ, Dept Pathol, Chilgok Hosp, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu 41933, South Korea; Kyungpook Natl Univ, Sch Med, Dept Physiol, Daegu 51944, South Korea | 59491926400; 57295299200; 57205603624; 23099068000; 57210160197; 7401969388; 57226185359; 57424663500 | jchana1996@knu.ac.kr;yuando@knu.ac.kr;stanleyhugo90@gmail.com;gochong@knu.ac.kr;jyparkmd@knu.ac.kr;hshan@knu.ac.kr;pathpyj@knu.ac.kr;joshua@knu.ac.kr; | LIFE-BASEL | LIFE-BASEL | 2075-1729 | 14 | 12 | SCIE | BIOLOGY | 2024 | 3.4 | 20.1 | 0 | 2025-05-07 | 1 | 1 | cervical cancer; cytology-based screening; distribution-augmented contrastive learning; self-supervised learning; precancerous cells | CYTOLOGY | cervical cancer; cytology-based screening; distribution-augmented contrastive learning; precancerous cells; self-supervised learning | English | 2024 | 2024-12 | 10.3390/life14121565 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Dual Biologic or Small Molecule Therapy in Refractory Pediatric Inflammatory Bowel Disease (DOUBLE-PIBD): A Multicenter Study from the Pediatric IBD Porto Group of ESPGHAN | Background: Current data on dual biologic therapy in children are limited. This multicenter study aimed to evaluate the effectiveness and safety of dual therapy in pediatric patients with inflammatory bowel disease (IBD). Methods: A retrospective study from 14 centers affiliated with the Pediatric IBD Interest and Porto Groups of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition. Included were children with IBD who underwent combinations of biologic agents or biologic and small molecule therapy for at least 3 months. Demographic, clinical, laboratory, endoscopic, and imaging data were collected. Adverse events were recorded. Results: Sixty-two children (35 Crohn's disease, 27 ulcerative colitis; median age 15.5 [interquartile range, 13.1-16.8] years) were included. They had all failed previous biologic therapies, and 47 (76%) failed at least 2 biologic agents. The dual therapy included an anti-tumor necrosis factor agent and vedolizumab in 30 children (48%), anti-tumor necrosis factor and ustekinumab in 21 (34%) children, vedolizumab and ustekinumab in 8 (13%) children, and tofacitinib with a biologic in 3 (5%) children. Clinical remission was observed in 21 (35%), 30 (50%), and 38 (63%) children at 3, 6, and 12 months, respectively. Normalization of C-reactive protein and decrease in fecal calprotectin to <250 mu g/g were achieved in 75% and 64%, respectively, at 12 months of follow-up. Twenty-nine (47%) children sustained adverse events, 8 of which were regarded as serious and led to discontinuation of therapy in 6. Conclusions: Dual biologic therapy may be effective in children with refractory IBD. The potential efficacy should be weighed against the risk of serious adverse events. LAY SUMMARY This multicenter study describes 62 children with refractory inflammatory bowel disease who received dual biologic therapy. Clinical remission was observed in 21 (35%), 30 (50%), and 38 (63%) children at 3, 6, and 12 months, respectively. Several serious adverse events were reported. | Yerushalmy-Feler, Anat; Olbjorn, Christine; Kolho, Kaija-Leena; Aloi, Marina; Musto, Francesca; Martin-de-Carpi, Javier; Lozano-Ruf, Ana; Yogev, Dotan; Matar, Manar; Scarallo, Luca; Bramuzzo, Matteo; de Ridder, Lissy; Kang, Ben; Norden, Christoph; Wilson, David C.; Tzivinikos, Christos; Turner, Dan; Cohen, Shlomi | Tel Aviv Univ, Dana Dwek Childrens Hosp, Pediat Gastroenterol Inst, Sackler Fac Med,Tel Aviv Sourasky Med Ctr, Tel Aviv, Israel; Akershus Univ Hosp, Dept Paediat & Adolescent Med, Lorenskog, Norway; Helsinki Univ Hosp, Childrens Hosp, Dept Paediat Gastroenterol, Helsinki, Finland; Univ Helsinki, Helsinki, Finland; Tampere Univ, Tampere, Finland; Sapienza Univ Rome, Umberto Hosp 1, Dept Maternal & Child Hlth, Pediat Gastroenterol & Liver Unit, Rome, Italy; Hosp St Joan Deu, Dept Pediat Gastroenterol Hepatol & Nutr, Barcelona, Spain; Hebrew Univ Jerusalem, Juliet Keiden Inst Pediat Gastroenterol & Nutr, Shaare Zedek Med Ctr, Jerusalem, Israel; Tel Aviv Univ, Inst Gastroenterol Nutr & Liver Dis, Sackler Fac Med, Schneider Childrens Med Ctr, Tel Aviv, Israel; Meyer Childrens Hosp, Gastroenterol & Nutr Unit, Florence, Italy; IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Gastroenterol Digest Endoscopy & Nutr Unit, Trieste, Italy; Sophia Childrens Univ Hosp, Erasmus Med Ctr, Dept Paediat Gastroenterol, Rotterdam, Netherlands; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Copenhagen Univ Hosp, Paediat Dept, Hvidovre, Denmark; Royal Hosp Children & Young People, Dept Paediat Gastroenterol & Nutr, Edinburgh, Scotland; Al Jalila Childrens Specialty Hosp, Dubai, U Arab Emirates | Bramuzzo, Matteo/K-2504-2018; 康, 奔/JMQ-0812-2023; Olbjørn, Christine/L-7176-2016; de Ridder, Lissy/A-1897-2013; Turner, Dan/KHT-2166-2024; SCARALLO, LUCA/GRF-4722-2022; Aloi, Marina/K-2496-2016 | 56016081800; 15760654500; 6701638121; 22950164000; 57489631300; 8617822100; 57223946362; 56888594200; 57193614026; 57204424323; 33067537800; 56146332500; 57194823199; 57217485861; 56480940600; 56230811200; 57198448551; 36808812900 | shlomico@tlvmc.gov.il; | INFLAMMATORY BOWEL DISEASES | INFLAMM BOWEL DIS | 1078-0998 | 1536-4844 | 30 | 2 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2024 | 4.3 | 20.1 | 10.69 | 2025-05-07 | 22 | 22 | dual biologics; Crohn's disease; ulcerative colitis | SEVERE CROHNS-DISEASE; MAINTENANCE THERAPY; ULCERATIVE-COLITIS; ACTIVITY INDEX; MODERATE; SAFETY; INFLIXIMAB; INDUCTION; EFFICACY; TOFACITINIB | Crohn's disease; dual biologics; ulcerative colitis | Adolescent; Biological Products; Child; Colitis, Ulcerative; Humans; Inflammatory Bowel Diseases; Necrosis; Retrospective Studies; Ustekinumab; acetylsalicylic acid; adalimumab; albumin; biological product; C reactive protein; calgranulin; corticosteroid; infliximab; Janus kinase inhibitor; tofacitinib; tumor necrosis factor inhibitor; ustekinumab; vedolizumab; biological product; ustekinumab; adolescent; adverse drug reaction; arthralgia; arthritis; Article; autoimmune hepatitis; biological therapy; body mass; cellulitis; child; Clostridium difficile infection; cohort analysis; colectomy; coronavirus disease 2019; Crohn disease; deep vein thrombosis; demographics; disability; disease exacerbation; drug withdrawal; eczema; endoscopy; enteric feeding; episcleritis; erythema nodosum; erythrocyte sedimentation rate; external otitis; fatigue; female; fever; folliculitis; follow up; headache; hematocrit; hemoglobin blood level; hospitalization; human; hypertransaminasemia; ileostomy; imaging; impetigo; inflammatory bowel disease; influenza; infusion; laboratory test; leukocyte count; magnetic resonance enterography; major clinical study; male; mouth ulcer; multicenter study; multivariate analysis; osteomyelitis; pediatric patient; peripheral arthritis; phenotype; predictor variable; primary sclerosing cholangitis; psoriasis; pyoderma gangrenosum; rash; retrospective study; school child; sinusitis; skin abscess; small molecule therapy; treatment indication; treatment response time; ulcerative colitis; ultrasound; univariate analysis; upper respiratory tract infection; urticaria; clinical trial; necrosis; ulcerative colitis | English | 2024 | 2024-02-01 | 10.1093/ibd/izad064 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Empirical Therapy Versus Tailored Therapy of Helicobacter pylori in Korea: Results of the K-CREATE Study | Background: The optimal duration of regimens for tailored therapy based on genotypic resistance for clarithromycin has yet to be established. Aim: This study was a nationwide, multicenter, randomized trial comparing empirical therapy with tailored therapy based on genotypic resistance for first-line eradication of Helicobacter pylori. We also compared the eradication rates of 7- and 14-day regimens for each group. Patients and Methods: Patients with H. pylori infection were first randomized to receive empirical or tailored therapy. Patients in each group were further randomized into 7- or 14-day regimens. Empirical therapy consisted of a triple therapy (TT) regimen (twice-daily doses of pantoprazole 40 mg, amoxicillin 1 g, and clarithromycin 500 mg) for 7 or 14 days. Tailored therapy consisted of TT of 7 or 14 days in patients without genotypic resistance. Patients with genotypic resistance were treated with bismuth quadruple therapy (BQT) regimens (twice-daily doses of pantoprazole 40 mg, three daily doses of metronidazole 500 mg, and four times daily doses of bismuth 300 mg and tetracycline 500 mg) for 7 or 14 days. A 13C-urea breath test assessed eradication rates. The primary outcome was eradication rates of each group. Results: A total of 593 patients were included in the study. The eradication rates were 65.7% (201/306) in the empirical therapy group and 81.9% (235/287) in the tailored therapy group for intention-to-treat analysis (p < 0.001). In the per-protocol analysis, the eradication rates of the empirical therapy and tailored groups were 70.3% (201/286) and 85.5% (235/274) (p < 0.001), respectively. There was no difference in compliance between the two groups. The rate of adverse events was higher in the tailored group compared to the empirical group (p < 0.001). Discussion: Our study confirmed that tailored therapy based on genotypic resistance was more effective than empirical therapy for H. pylori eradication in Korea. However, no significant difference was found between 7- and 14-day regimens for each group. Future studies are needed to determine the optimal duration of therapy for empirical and tailored therapy regimens. | Kim, Joon Sung; Kim, Byung-Wook; Kim, Jin Il; Chung, Woo Chul; Jung, Sung Woo; Bang, Chang Seok; Kim, Gwang Ha; Jeon, Seon Woo; Joo, Moon Kyoung; Lee, Si Hyung; Lim, Yun Jeong; Sung, Jae Kyu; Seo, Seung Young; Park, Sun Young; Lee, Wan Sik; Lee, Hang Lak; Kim, Ki Bae; Kim, Heung Up | Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Catholic Univ Korea, Yeouido St Marys Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Catholic Univ Korea, St Vincent Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Korea Univ, Coll Med, Ansan Hosp, Dept Internal Med, Ansan, South Korea; Hallym Univ, Coll Med, Dept Internal Med, Chuncheon Sacred Heart Hosp, Chunchon, South Korea; Pusan Natl Univ, Coll Med, Dept Internal Med, Busan, South Korea; Pusan Natl Univ Hosp, Biomed Res Inst, Busan, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Gastroenterol, Chilgok, South Korea; Korea Univ, Guro Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Yeungnam Univ, Coll Med, Dept Internal Med, Daegu, South Korea; Dongguk Univ, Coll Med, Dept Internal Med, Ilsan Hosp, Goyang, South Korea; Chungnam Natl Univ, Coll Med, Dept Internal Med, Daejeon, South Korea; Jeonbuk Natl Univ, Med Sch, Dept Internal Med, Jeonju, South Korea; Chonnam Natl Univ Hosp, Dept Internal Med, Gwangju, South Korea; Chonnam Natl Univ, Hwasun Hosp, Dept Internal Med, Hwasun, South Korea; Hanyang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Chungbuk Natl Univ Hosp, Dept Internal Med, Cheongju, South Korea; Jeju Natl Univ, Coll Med, Dept Internal Med, Jeju, South Korea | ; Kim, Woo/D-2733-2015; Kim, Gwang Ha/ABF-3932-2021; Lee, Si/ABH-1408-2020; Kim, Ki Bae/KYQ-0127-2024; Bang, Chang SEOK/I-9689-2019; Lee, Jeong/JFA-4725-2023; Kim, Jin Young/AAB-6510-2020; Jeon, Seongwoo/AAU-4618-2020; LIM, Yun Jeong/KVY-6446-2024 | 25932931200; 58940148600; 58252089900; 35075629400; 35174493300; 57991522300; 35214772400; 59510684700; 35313509000; 35771122400; 56501161800; 8439931900; 56883674300; 59261188700; 57208140974; 57219409756; 56106965700; 58028929800 | gastro@catholic.ac.kr; | HELICOBACTER | HELICOBACTER | 1083-4389 | 1523-5378 | 29 | 4 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;MICROBIOLOGY | 2024 | 4.3 | 20.1 | 1.35 | 2025-05-07 | 2 | 2 | drug resistance; eradication; Helicobacter; PCR; tailored therapy | ERADICATION; RESISTANCE; TIME | drug resistance; eradication; Helicobacter; PCR; tailored therapy | Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Clarithromycin; Drug Resistance, Bacterial; Drug Therapy, Combination; Female; Genotype; Helicobacter Infections; Helicobacter pylori; Humans; Male; Metronidazole; Middle Aged; Pantoprazole; Republic of Korea; Treatment Outcome; Young Adult; amoxicillin; bismuth; clarithromycin; metronidazole; pantoprazole; placebo; tetracycline; amoxicillin; antiinfective agent; clarithromycin; metronidazole; pantoprazole; adult; antibiotic therapy; Article; bacterial clearance; clinical assessment; controlled study; diarrhea; double blind procedure; drug dose regimen; drug efficacy; drug safety; empirical therapy; epigastric discomfort; female; gastrointestinal endoscopy; genetic resistance; genotype; headache; Helicobacter infection; human; intermethod comparison; Korea; major clinical study; male; middle aged; multicenter study; nausea; patient compliance; polymerase chain reaction; population research; pruritus; randomized controlled trial; tailored therapy; taste disorder; treatment duration; treatment outcome; urea breath test; weakness; aged; antibiotic resistance; clinical trial; combination drug therapy; drug effect; drug therapy; genetics; Helicobacter infection; Helicobacter pylori; microbiology; South Korea; young adult | English | 2024 | 2024-07 | 10.1111/hel.13126 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Improving Tumor-Infiltrating Lymphocytes Score Prediction in Breast Cancer with Self-Supervised Learning | Tumor microenvironment (TME) plays a pivotal role in immuno-oncology, which investigates the intricate interactions between tumors and the human immune system. Specifically, tumor-infiltrating lymphocytes (TILs) are crucial biomarkers for evaluating the prognosis of breast cancer patients and have the potential to refine immunotherapy precision and accurately identify tumor cells in specific cancer types. In this study, we conducted tissue segmentation and lymphocyte detection tasks to predict TIL scores by employing self-supervised learning (SSL) model-based approaches capable of addressing limited labeling data issues. Our experiments showed a 1.9% improvement in tissue segmentation and a 2% improvement in lymphocyte detection over the ImageNet pre-training model. Using these SSL-based models, we achieved a TIL score of 0.718 with a 4.4% improvement. In particular, when trained with only 10% of the entire dataset, the SwAV pre-trained model exhibited a superior performance over other models. Our work highlights improved tissue segmentation and lymphocyte detection using the SSL model with less labeled data for TIL score prediction. | Kim, Sijin; Hasan, Kazi Rakib; Ando, Yu; Ko, Seokhwan; Lee, Donghyeon; Park, Nora Jee-Young; Cho, Junghwan | Kyungpook Natl Univ, Dept Biomed Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu 41944, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Pathol, Daegu 41404, South Korea; Kyungpook Natl Univ, Clin Om Inst, Daegu 41405, South Korea | RAKIB HASAN, KAZI/GNP-8208-2022; Cho, Junghwan/AAK-4752-2020 | 59121832700; 59123122700; 57295299200; 57205603624; 57870503500; 57226185359; 57424663500 | zmgpg123@knu.ac.kr;krhasan02@knu.ac.kr;yuando@knu.ac.kr;skanny@knu.ac.kr;lowelkids24@knu.ac.kr;pathpjy@knu.ac.kr;joshua@knu.ac.kr; | LIFE-BASEL | LIFE-BASEL | 2075-1729 | 14 | 1 | SCIE | BIOLOGY | 2024 | 3.4 | 20.1 | 0.66 | 2025-04-16 | 2 | 3 | self-supervised learning; histopathology; breast cancer; tumor-infiltrating lymphocytes; tissue segmentation and lymphocyte detection | HISTOPATHOLOGY IMAGES; CLASSIFICATION | breast cancer; histopathology; self-supervised learning; tissue segmentation and lymphocyte detection; tumor-infiltrating lymphocytes | English | 2024 | 2024-01 | 10.3390/life14010090 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Maternal and Neonatal Outcomes Based on Changes in Glycosylated Hemoglobin Levels During First and Second Trimesters of Pregnancy in Women with Pregestational Diabetes: Multicenter, Retrospective Cohort Study in South Korea | This study compared glycosylated hemoglobin (HbA1c) levels in the first and second trimesters of pregnancy and assessed maternal and neonatal outcomes according to HbA1c variations among women with pregestational diabetes. This retrospective, multicenter Korean study involved mothers with diabetes who had given birth in 17 hospitals. A total of 292 women were divided into three groups based on HbA1c levels during the first and second trimesters: women with HbA1c levels maintained at = 6.5% (poorly-controlled [PC] group); and women with HbA1c >= 6.5% in the first trimester but <6.5% in the second trimester (improved-control [IC] group). The PC group had the highest pregnancy-associated hypertension (PAH) incidence, while the incidence did not significantly differ between the WC and IC groups. The receiver operating characteristic (ROC) curve indicated that HbA1c in the second trimester could predict PAH with a cut-off value of 5.7%. The PC versus WC versus IC group showed statistically significantly higher neonatal birthweight and significantly higher rates of large for gestational age (LGA); however, those were not significantly different between the WC and IC groups. HbA1c levels in the second trimester could predict LGA, with a cut-off value of 5.4%. Therefore, the second trimester HbA1c levels were significantly associated with both maternal and neonatal outcomes. | Kim, Mi Ju; Park, Suyeon; Choi, Sooran; Hong, Subeen; Sung, Ji-Hee; Seol, Hyun-Joo; Lee, Joon Ho; Kim, Seung Cheol; Choi, Sae-Kyoung; Kwon, Ji Young; Lee, Seung Mi; Lee, Se Jin; Hwang, Han-Sung; Lee, Gi Su; Park, Hyun Soo; Lee, Soo-Jeong; Cho, Geum Joon; Bae, Jin-Gon; Seong, Won Joon; Ko, Hyun Sun | Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu 41944, South Korea; Inha Univ, Coll Engn, Dept Elect Engn, Incheon 22212, South Korea; Catholic Univ Korea, Incheon St Marys Hosp, Dept Obstet & Gynecol, Seoul 06591, South Korea; Sungkyunkwan Univ, Dept Obstet & Gynecol, Seoul 03063, South Korea; Kyung Hee Univ, Dept Obstet & Gynecol, Seoul 02447, South Korea; Yonsei Univ, Yonsei Univ Hlth Syst, Dept Obstet & Gynecol, Seoul 03722, South Korea; Pusan Natl Univ, Dept Obstet & Gynecol, Busan 46241, South Korea; Seoul Natl Univ Hosp, Dept Obstet & Gynecol, Seoul 08826, South Korea; Kangwon Natl Univ, Dept Appl Anim Sci, Gangwon 24341, South Korea; Konkuk Univ, Dept Obstet & Gynecol, Seoul 05030, South Korea; Keimyung Univ, Sch Med, Dept Obstet & Gynecol, Daegu 42601, South Korea; Providence St Joseph Eureka Hosp, Family Med Residency, Eureka, CA 95501 USA; Univ Ulsan, Coll Med, Dept Obstet & Gynecol, Ulsan 44610, South Korea; Korea Univ, Dept Obstet & Gynecol, Seoul 02841, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Obstet & Gynecol, Seoul 06591, South Korea | ; Kim, seung chul/D-9216-2018; Lee, Soo-Jeong/A-4001-2015; Lee, Joon HO/KBC-5407-2024; Kim, Mi Ju/HGU-8470-2022 | 55908927600; 57460689900; 55756824400; 57208189052; 56347330000; 15924081200; 59722192200; 57484521500; 36924484600; 35218066400; 50262091500; 57206256821; 17345595900; 58022196600; 57201459522; 55989527600; 12545334500; 57215844401; 26656946000; 37026301100 | ties1004@naver.com;hi0438@naver.com;csran@inha.ac.kr;unihsy@naver.com;jihee.sung@samsung.com;seolhj@khu.ac.kr;doctor-joon@hanmail.net;ksch0127@naver.com;obgysk@catholic.ac.kr;jiyoungk@catholic.ac.kr;lbsm@snu.ac.kr;23wls@naver.com;20080251@kuh.ac.kr;cllgs315@naver.com;hsparkmd@gmail.com;exsjlee@uuh.ulsan.kr;md_cho@hanmail.net;gonmd@dsmc.or.kr;wjseong@knu.ac.kr;mongkoko@catholic.ac.kr; | LIFE-BASEL | LIFE-BASEL | 2075-1729 | 14 | 12 | SCIE | BIOLOGY | 2024 | 3.4 | 20.1 | 0 | 2025-05-07 | 0 | 0 | first trimester; glycosylated hemoglobin; maternal outcomes; neonatal outcomes; pregestational diabetes; second trimester | RISK; HYPERGLYCEMIA; HBA(1C) | first trimester; glycosylated hemoglobin; maternal outcomes; neonatal outcomes; pregestational diabetes; second trimester | English | 2024 | 2024-12 | 10.3390/life14121575 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Meaning-making while staying connected matters in psychological adaptation during pandemic: a longitudinal moderated mediation study | Adversity may bring about both negative and positive changes in psychological adaptation. Although there is mounting evidence regarding the psychological distress during the pandemic, the other side of posttraumatic change, posttraumatic growth (PTG) and its predictors are relatively underexamined. Moreover, there is a paucity of longitudinal investigations that examined intra- and interpersonal predictors responsible for both sides of psychological adaptation. Therefore, this study comprehensively examined the longitudinal relationship among cognitive processing, social support, and adaptation during the pandemic using a moderated mediation model. Specifically, it was tested whether two types of event-related rumination mediated the link between perceived stress and ambilateral adaptational outcomes, and whether social support moderated the mediating pathways of ruminations on adaptation. After informed consent, a representative sample of adults was followed up for over a year, and answered a package of online questionnaires. The results showed that intrusive rumination prospectively predicted greater psychological distress and less PTG in response to stress, whereas deliberate rumination led to less psychological distress and more PTG over time. As predicted, the indirect protective effect of deliberate rumination was stronger when perceived social support was higher. This longitudinal study highlighted the core factors responsible for continued suffering and personal growth during the pandemic. These results have both practical and clinical implications for mental healthcare in the post-COVID era, when the heterogeneity of psychological adaptation increases and preparation for the next pandemic is warranted. | Kim, Bin-Na; Kang, Hyo Shin; Park, Jungkyu | Gachon Univ, Dept Psychol, Seongnam, South Korea; Kyungpook Natl Univ, Dept Psychol, Daegu, South Korea | 56125185200; 57219595147; 56206565000 | hyoshin.kang@knu.ac.kr;jkp@knu.ac.kr; | FRONTIERS IN PSYCHOLOGY | FRONT PSYCHOL | 1664-1078 | 15 | SSCI | PSYCHOLOGY, MULTIDISCIPLINARY | 2024 | 2.9 | 20.1 | 0 | 2025-04-16 | 0 | 1 | psychological distress; posttraumatic growth; social support; event-related rumination; pandemic | POSTTRAUMATIC GROWTH INVENTORY; DELIBERATE RUMINATION; STRESS; ADOLESCENTS; RESILIENCE; HEALTH; LIFE; US | event-related rumination; pandemic; posttraumatic growth; psychological distress; social support | English | 2024 | 2024-02-29 | 10.3389/fpsyg.2024.1364903 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Review | Role of Tumor-Associated Macrophages in Cervical Cancer: Integrating Classical Perspectives with Recent Technological Advances | Tumor-associated macrophages (TAMs) play a pivotal role in the tumor microenvironment, influencing cancer progression and contributing to poor prognosis. However, in cervical cancer (CC), their significance and involvement are relatively less studied than in other gynecological cancers such as ovarian and endometrial cancer. This review aims to provide an overview of TAMs, covering their origins and phenotypes and their impact on CC progression, along with major TAM-targeted therapeutic approaches. Furthermore, we advocate for the integration of cutting-edge research methodologies, such as single-cell RNA sequencing and spatial RNA sequencing, to enable in-depth and comprehensive investigations into TAMs in CC, which would be beneficial in leading to more personalized and effective immunotherapy strategies for patients with CC. | Choi, Yeseul; Lee, Donghyeon; Kim, Na Young; Seo, Incheol; Park, Nora Jee-Young; Chong, Gun Oh | Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, Grad Program, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu 41944, South Korea; Kyungpook Natl Univ, Clin Om Inst, Daegu 41405, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Pathol, Daegu 41404, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Obstet & Gynecol, Daegu 41404, South Korea | ; Kim, Na-young/KHU-6533-2024 | 57226123444; 57870503500; 59122269200; 56022683900; 57226185359; 23099068000 | yeseul.choi830@knu.ac.kr;lowellkids24@knu.ac.kr;skduddl98@knu.ac.kr;iseo@knu.ac.kr;pathpjy@knu.ac.kr;gochong@knu.ac.kr; | LIFE-BASEL | LIFE-BASEL | 2075-1729 | 14 | 4 | SCIE | BIOLOGY | 2024 | 3.4 | 20.1 | 0.86 | 2025-05-07 | 6 | 5 | cervical cancer; tumor-associated macrophage; M1-like phenotype; M2-like phenotype; angiogenesis; metastasis; multi-omics; single-cell transcriptomics; spatial transcriptomics | SQUAMOUS-CELL CARCINOMA; INTRAEPITHELIAL NEOPLASIA; CLINICAL-SIGNIFICANCE; PD-L1 EXPRESSION; PROGRESSION; ANGIOGENESIS; DIVERSITY; RISK; LYMPHANGIOGENESIS; POLARIZATION | angiogenesis; cervical cancer; M1-like phenotype; M2-like phenotype; metastasis; multi-omics; single-cell transcriptomics; spatial transcriptomics; tumor-associated macrophage | English | 2024 | 2024-04 | 10.3390/life14040443 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | The Mclust Analysis of Tumor Budding Unveils the Role of the Collagen Family in Cervical Cancer Progression | In RNA-seq data analysis, condensing the gene count matrix size is pivotal for downstream investigations, particularly pathway analysis. For this purpose, harnessing machine learning attracts increasing interest, while conventional methodologies depend on p-value comparisons. In this study, 20 tissue samples from real-world cervical cancers were subjected to sequencing, followed by the application of the Mclust algorithm to delineate an optimal cluster. By stratifying tumor budding into high and low groups and quantifying the epithelial-to-mesenchymal transition (EMT) score to scrutinize tumor budding, we discerned 24 EMT-related genes, with 5 showing strong associations with cervical cancer prognosis. Our observations elucidate a biological flow wherein EMT, Matrix Metallopep-tidase 2 (MMP2), and extracellular matrix (ECM) degradation are interconnected, ultimately leading to collagen type VI and exacerbating the prognosis of cervical cancer. The present study underscores an alternative method for selecting useful EMT-related genes by employing an appropriate clustering algorithm, thereby avoiding classical methods while unveiling novel insights into cervical cancer etiology and prognosis. Moreover, when comparing high and low tumor budding, collagen type VI emerges as a potential gene marker for the prognosis of cervical cancer. | Lee, Olive E. M.; Le, Tan Minh; Chong, Gun Oh; Cho, Junghwan Joshua; Park, Nora Jee-Young | Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Program BK21 4, Daegu 41944, South Korea; Kyungpook Natl Univ, Clin Om Inst, Daegu 41405, South Korea; Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu 41404, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Obstet & Gynecol, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu 41944, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Pathol, Daegu 41404, South Korea | ; Cho, Junghwan/AAK-4752-2020; Le, Tan/ITT-2150-2023 | 58029901300; 57870749600; 23099068000; 57424663500; 57226185359 | pathpjy@knu.ac.kr; | LIFE-BASEL | LIFE-BASEL | 2075-1729 | 14 | 8 | SCIE | BIOLOGY | 2024 | 3.4 | 20.1 | 0.6 | 2025-05-07 | 1 | 1 | cervical cancer; Mclust; tumor budding; collagen type VI; EMT; ECM | EXPRESSION; BIOMARKER; SELECTION | cervical cancer; collagen type VI; ECM; EMT; Mclust; tumor budding | English | 2024 | 2024-08 | 10.3390/life14081004 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Metformin treatment is associated with improved survival in diabetic patients hospitalized with acute heart failure: A prospective observational study using the Korean acute heart failure registry data | Aims: Although the hypothesis that metformin is beneficial for patients with diabetes and heart failure (HF) has been steadily raised, there is limited data on metformin use in patients with acute HF. We analyzed the association of metformin on all-cause mortality in hospitalized patients with type 2 diabetes and acute HF.Methods: The Korean Acute Heart Failure registry prospectively enrolled patients hospitalized for acute HF from 2011 to 2014. Among this cohort, we analyzed patients with diabetes with baseline estimated glomerular filtration rate (eGFR) of 30 ml/min/1.73 m(2) or more. We analyzed the all-cause mortality and re-hospitalization for HF within 1 year after discharge. Inverse probability treatment weighting method was used to adjust baseline differences on metformin treatment.Results: The study analyzed data from 1,309 patients with HF and diabetes (mean age 69 years, 56 % male). Among them, 613 (47 %) patients were on metformin at admission. During the median follow-up period of 11 months, 132 (19 %) and 74 (12 %) patients not receiving and receiving metformin treatment died, respectively. The mortality rate was lower in metformin users than in non-users (hazard ratio 0.616 [0.464-0.819] P= 60 ml/min/1.73 m(2), P-for-interaction=0.176) or left ventricular ejection fraction (= 50 %, P-for-interaction=0.224).Conclusions: Metformin treatment at the time of admission was associated with a lower risk for 1-year mortality in patients with diabetes, hospitalized for acute HF. | Chun, Kyeong-Hyeon; Oh, Jaewon; Lee, Chan Joo; Park, Jin Joo; Lee, Sang Eun; Kim, Min-Seok; Cho, Hyun-Jai; Choi, Jin-Oh; Lee, Hae-Young; Hwang, Kyung-Kuk; Kim, Kye Hun; Yoo, Byung-Su; Choi, Dong-Ju; Baek, Sang Hong; Jeon, Eun-Seok; Kim, Jae-Joong; Cho, Myeong-Chan; Chae, Shung Chull; Oh, Byung-Hee; Kang, Seok-Min | Natl Hlth Insurance Serv Ilsan Hosp, Div Cardiol, Goyang, South Korea; Yonsei Univ, Severance Hosp, Cardiovasc Res Inst, Cardiol Div,Coll Med, Seoul, South Korea; Seoul Natl Univ, Div Cardiol, Bundang Hosp, Seongnam, South Korea; Asan Med Ctr, Div Cardiol, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Sungkyunkwan Univ, Coll Med, Seoul, South Korea; Chungbuk Natl Univ, Dept Internal Med, Coll Med, Cheongju, South Korea; Chonnam Natl Univ, Dept Internal Med, Gwangju, South Korea; Yonsei Univ, Dept Internal Med, Wonju Coll Med, Wonju, South Korea; Catholic Univ Korea, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Dept Internal Med, Coll Med, Daegu, South Korea; Mediplex Sejong Hosp, Dept Internal Med, Incheon, South Korea | ; Choi, Dong-Ju/J-5686-2012; Lee, Jeong Hoon/AAF-2400-2020; Oh, Byung-Hee/G-9875-2011; choi, jo/O-5940-2014 | 57207775021; 58392341700; 57226133622; 35799900000; 57207065107; 57212315719; 35285421400; 15848011800; 56151235500; 7402426370; 56150430800; 7102851884; 35274349200; 7201371594; 7004279641; 57225030259; 58092080500; 7101962036; 57216293873; 7405685375 | smkang@yuhs.ac; | DIABETES & METABOLISM | DIABETES METAB | 1262-3636 | 1878-1780 | 50 | 1 | SCIE | ENDOCRINOLOGY & METABOLISM | 2024 | 4.7 | 20.2 | 0.58 | 2025-04-16 | 1 | 1 | Acute heart failure; Mortality; Metformin; Type 2 diabetes | CLINICAL-OUTCOMES; GLUCOSE CONTROL; MORTALITY; RISK; MELLITUS | Acute heart failure; Mortality, Metformin; Type 2 diabetes | Aged; Diabetes Mellitus, Type 2; Female; Heart Failure; Hospitalization; Humans; Male; Metformin; Republic of Korea; Routinely Collected Health Data; Stroke Volume; Ventricular Function, Left; acarbose; angiotensin receptor antagonist; beta adrenergic receptor blocking agent; dipeptidyl carboxypeptidase inhibitor; dipeptidyl peptidase IV inhibitor; glitazone derivative; glucose; hemoglobin A1c; hydroxymethylglutaryl coenzyme A reductase inhibitor; insulin; loop diuretic agent; metformin; mineralocorticoid antagonist; sulfonylurea; thiazide diuretic agent; acute heart failure; aged; all cause mortality; Article; body mass; clinical outcome; cohort analysis; controlled study; diabetic patient; estimated glomerular filtration rate; female; follow up; glucose blood level; heart left ventricle ejection fraction; hospital admission; hospital discharge; hospitalization; human; insulin treatment; left ventricular systolic dysfunction; major clinical study; male; non insulin dependent diabetes mellitus; observational study; prescription; prospective study; register; survival; thorax radiography; complication; heart failure; heart left ventricle function; heart stroke volume; non insulin dependent diabetes mellitus; routinely collected health data; South Korea | English | 2024 | 2024-01 | 10.1016/j.diabet.2023.101504 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Letter | Rethinking the diagnosis of double-seronegative myasthenia gravis | Kim, Sohyeon; Eun, Mi-Yeon; Lee, Jae-Joon; Seok, Hung Youl | Keimyung Univ, Dongsan Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Keimyung Univ, Dongsan Hosp, Sch Med, Dept Neurol, 1035 Dalgubeol Daero, Daegu 42601, South Korea | Seok, Hung Youl/HZI-4365-2023; Eun, Mi-Yeon/AAV-2877-2021 | 57214724357; 36463396500; 57209362997; 24472118000 | shy2354@gmail.com; | EUROPEAN JOURNAL OF NEUROLOGY | EUR J NEUROL | 1351-5101 | 1468-1331 | 31 | 3 | SCIE | CLINICAL NEUROLOGY;NEUROSCIENCES | 2024 | 3.9 | 20.2 | 0 | 2025-05-07 | 0 | 0 | Autoantibodies; Humans; Myasthenia Gravis; Receptors, Cholinergic; autoantibody; cholinergic receptor; clinical feature; diagnostic accuracy; diagnostic procedure; double seronegative myasthenia gravis; human; immunotherapy; Letter; myasthenia gravis; nerve stimulation; prevalence; repetitive nerve stimulation; serodiagnosis; single fiber electromyography; treatment outcome | English | 2024 | 2024-03 | 10.1111/ene.16151 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Advanced electromagnetic wave-based method for characterizing defects in cement-based structures using time domain reflectometry | This study presents novel electromagnetic wave-based methods for evaluating the integrity of cement-based structures using time domain reflectometry (TDR). Two cement-based plates with embedded rebars are prepared under sound and defective conditions. TDR tests are carried out using transmission lines with various numbers of artificial joints, and electromagnetic waves are measured to assess the integrity of the plates. The experimental results show that the travel time of electromagnetic waves is consistently longer in sound plates than in defective ones, and an increase in the reflection coefficients is observed in the defect zone of the defective plates. Electromagnetic wave velocities are higher in the defective plates, especially when connectors are present in the transmission line. A novel approach based on the area of the reflection coefficient provides larger areas in the defective plates, and the attenuation effect of the electromagnetic waves induces a difference in the areas of the reflection coefficient between the two defect conditions. An alternative method using the centroid of the defect zone slightly overestimates the location of the defect zone. The length of the defect zone is estimated using the defect ratio and wave velocities of cement, air, and plate. The length of the defect zone can also be calculated using the travel times within the plate, total measured length of the plate, and wave velocities in the cement and air. Therefore, the electromagnetic wave-based methods proposed in this study may be useful for estimating the location and length of defect zones by considering attenuation effects. | Lee, Dongsoo; Lee, Jong-Sub; Ju, Young K.; Byun, Yong-Hoon | Korea Univ, Sch Civil Environm & Architectural Engn, Seoul 02841, South Korea; Kyungpook Natl Univ, Dept Agr Civil Engn, 80 Daehak Ro, Daegu 41566, South Korea | Byun, Yong-Hoon/JKI-8441-2023; Lee, Jong-Sub/G-2752-2012 | 57483228200; 55690048400; 8505936200; 42761048000 | yhbyun@knu.ac.kr; | COMPUTERS AND CONCRETE | COMPUT CONCRETE | 1598-8198 | 1598-818X | 33 | 5 | SCIE | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS;CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL;MATERIALS SCIENCE, CHARACTERIZATION & TESTING | 2024 | 3.3 | 20.3 | 1.45 | 2025-05-07 | 3 | 3 | cement; defect; electromagnetic wave; integrity; time domain reflectometry | STRENGTH | cement; defect; electromagnetic wave; integrity; time domain reflectometry | Cements; Circular waveguides; Electric lines; Electromagnetic wave attenuation; Electromagnetic wave emission; Plates (structural components); Reflection; Reflectometers; Time domain analysis; Travel time; Attenuation effect; Cement-based; Condition; Defective plates; Integrity; Time domain reflectometry; Transmission-line; Travel-time; Wave based method; Wave velocity; Defects | English | 2024 | 2024-11 | 10.12989/cac.2024.33.5.621 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Application of shrinkage prediction models to restraint crack formation in unbonded post-tensioned slabs | This study aims to investigate the effect of restraint configuration on crack formation due to shrinkage-and-creep-induced volumetric change in unbonded post-tensioned slabs. The first part of this study focuses on the comparison of existing shrinkage and creep calculation models that are used to predict the volume-changing behavior of concrete. The second part of this study presents the finite element analysis of a series of architectural configuration prototypes subjected to shrinkage and creep, which comprise unbonded post-tensioned slabs with various restraint configurations. The shrinkage and creep effects were simulated in the analysis by imposing strains obtained from one selected calculation model. The results suggest that a slab up to 300 ft. (90 m) in length does not require a closure strip if it is unrestrained by perimeter walls, and that the most effective restraint crack mitigation strategy for a slab restrained by perimeter walls is a partial wall release. | Lara, Gabriela R. Martinez; Shin, Myoungsu; Byun, Yong-Hoon; Zi, Goangseup; Kang, Thomas H-K. | Seoul Natl Univ, Dept Architecture & Architectural Engn, 1 Gwanak Ro, Seoul 08826, South Korea; Seoul Natl Univ, Inst Engn Res, 1 Gwanak Ro, Seoul 08826, South Korea; Ulsan Natl Inst Sci & Technol UNIST, Sch Urban & Environm Engn, 50 UNIST Gil, Ulsan 44919, South Korea; Kyungpook Natl Univ, Sch Agr Civil & Bioind Engn, 80 Daehak Ro, Daegu 41566, South Korea; Korea Univ, Sch Civil Environm & Architectural Engn, Seoul 02841, South Korea | Kang, Thomas/AAP-5210-2020; Byun, Yong-Hoon/JKI-8441-2023; Zi, Goangseup/A-6157-2012; Shin, Myoungsu/F-4133-2010 | 58965523300; 7401537676; 42761048000; 6701704145; 26643496900 | tkang@snu.ac.kr; | COMPUTERS AND CONCRETE | COMPUT CONCRETE | 1598-8198 | 1598-818X | 33 | 4 | SCIE | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS;CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL;MATERIALS SCIENCE, CHARACTERIZATION & TESTING | 2024 | 3.3 | 20.3 | 0 | 2025-05-07 | 0 | 0 | crack formation; post-tensioning concrete slabs; restraint crack; shrinkage prediction | DRYING SHRINKAGE; CREEP; DESIGN | crack formation; post-tensioning concrete slabs; restraint crack; shrinkage prediction | Crack initiation; Creep; Forecasting; Shrinkage; Calculation models; Perimeter walls; Post-tensioned slabs; Post-tensioning concrete slab; Posttensioning; Restraint crack; Shrinkage and creep; Shrinkage prediction; Shrinkage prediction model; Volumetric changes; Concrete slabs | English | 2024 | 2024-04 | 10.12989/cac.2024.33.4.349 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Hyperparameter Tuning with Gaussian Processes for Optimal Abstraction Control in Simulation-based Optimization of Smart Semiconductor Manufacturing Systems | Smart manufacturing utilizes digital twins that are virtual forms of their production plants for analyzing and optimizing decisions. Digital twins have been mainly developed as discrete-event models (DEMs) to represent the detailed and stochastic dynamics of productions in the plants. The optimum decision is achieved after simulating the DEM-based digital twins under various what-if decision candidates; thus, simulation acceleration is crucial for rapid optimum determination for given problems. For the acceleration of discrete-event simulations, adaptive abstraction-level conversion approaches have been previously proposed to switch active models of each machine group between a set of DEM components and a corresponding lookup table-based mean-delay model during runtime. The switching is decided by detecting the machine group's convergence into (or divergence from) a steady state. However, there is a tradeoff between speedup and accuracy loss in the adaptive abstraction convertible simulation (AACS), and inaccurate simulation can degrade the quality of the optimum (i.e., the distance between the calculated optimum and the actual optimum). In this article, | Seok, Moon gi; Tan, Wen jun; Su, Boyi; Cai, Wentong; Kwon, Jisu; Choi, Seon han | Dongguk Univ, Dept Comp Sci & Engn, Seoul, South Korea; Nanyang Technol Univ, Sch Comp Sci & Engn, Singapore, Singapore; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu, South Korea; Ewha Womans Univ, Grad Program Smart Factory, Seoul, South Korea | ; Cai, Wentong/A-3720-2011; Tan, Wen/F-9932-2015 | 36683242700; 55445115300; 58380231400; 7401711207; 57215531728; 57199723590 | mgseok@dgu.ac.kr;wjtan@ntu.edu.sg;bsu@ntu.edu.sg;ASWTCAI@ntu.edu.sg;kjisu96@knu.ac.kr;eonhan.choi@ewha.ac.kr;seonhan.choi@ewha.ac.kr; | ACM TRANSACTIONS ON MODELING AND COMPUTER SIMULATION | ACM T MODEL COMPUT S | 1049-3301 | 1558-1195 | 35 | 1 | SCIE | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS;MATHEMATICS, APPLIED | 2024 | 1.9 | 20.3 | 0.83 | 2025-05-07 | 1 | 2 | Simulation-based optimization; runtime abstraction-level conversion; discrete-event modeling; manufacturing-system simulation | LEVEL CONVERSION; DESIGN | Additional Key Words and PhrasesSimulation-based optimization; discrete-event modeling; manufacturing-system simulation; runtime abstraction-level conversion | Gaussian distribution; Process control; Smart manufacturing; Stochastic control systems; Abstraction level; Additional key word and phrasessimulation-based optimization; Discrete event models; Hyper-parameter; Key words; Level conversions; Manufacturing system simulations; Optimisations; Run-time abstractions; Runtime abstraction-level conversion; Budget control | English | 2024 | 2024-11 | 10.1145/3646549 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Image-based characterization of internal erosion around pipe in earth dam | Internal erosion around pipes can lead to the failure of earth dams through various mechanisms. This study investigates the displacement patterns in earth dam models under three different failure modes due to internal erosion, using digital image correlation (DIC) methods. Three failure modes-erosion along a pipe (FM1), pipe leakage leading to soil erosion (FM2), and erosion in a pipe due to defects (FM3)-are analyzed using two- and three-dimensional image- processing techniques. The internal displacement of the cross-sectional area and the surface displacement of the downstream slope in the dam models are monitored using an image acquisition system. Physical model tests reveal that FM1 exhibits significant displacement on the upper surface of the downstream slope, FM2 shows focused displacement around the pipe defect, and FM3 demonstrates increased displacement on the upstream slope. The variations in internal and surface displacements with time depend on the segmented area and failure mode. Analyzing the relationships between internal and surface displacements using Pearson correlation coefficients reveals various displacement patterns for the segmented areas and failure modes. Therefore, the image-based characterization methods presented in this study may be useful for analyzing the displacement distribution and behavior of earth dams around pipes, and further, for understanding and predicting their failure mechanisms. | Kim, Dong-Ju; Aregbesola, Samuel OIamide; Lee, Jong-Sub; Cho, Hunhee; Byun, Yong-Hoon | Korea Univ, Sch Civil Environm & Architectural Engn, 145 Anam Ro, Seoul 02841, South Korea; Kyungpook Natl Univ, Dept Agr Civil Engn, 80 Daehak Ro, Daegu 41566, South Korea | Byun, Yong-Hoon/JKI-8441-2023; Lee, Jong-Sub/G-2752-2012; Aregbesola, Samuel/LXV-8805-2024 | 7409760881; 58631316600; 55690048400; 8590921600; 42761048000 | yhbyun@knu.ac.kr; | COMPUTERS AND CONCRETE | COMPUT CONCRETE | 1598-8198 | 1598-818X | 33 | 5 | SCIE | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS;CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL;MATERIALS SCIENCE, CHARACTERIZATION & TESTING | 2024 | 3.3 | 20.3 | 2.42 | 2025-05-07 | 5 | 5 | digital image correlation; displacement pattern; earth dam; failure mode; internal erosion | DEFORMATION MEASUREMENT; EMBANKMENT DAM; FAILURE | digital image correlation; displacement pattern; earth dam; failure mode; internal erosion | Correlation methods; Erosion; Failure (mechanical); Failure modes; Strain measurement; Surface measurement; Digital image correlation methods; Digital image correlations; Displacement patterns; Down-stream; Image-based; Internal erosion; Soil erosion; Surface displacement; Three-dimensional image processing; Two-dimensional; Image correlation | English | 2024 | 2024-11 | 10.12989/cac.2024.33.5.481 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Pleiotropic functions of SscA on the asexual spore of the human pathogenic fungus Aspergillus fumigatus | Asexual spores, called conidia, are key reproductive fungal particles that enable survival in harsh environmental conditions or host systems. The conidia can infect humans, animals, and plants to cause various fungal diseases. Transcription factors, including VosA, WetA, and SscA, have key roles in conidia formation and long-term survival in Aspergillus nidulans. Herein, we report the pleiotropic functions of SscA in the conidia of the human pathogen A. fumigatus. The deletion of sscA increased conidia formation despite decreased fungal growth. Absence of sscA impaired long-term survival and reduced spore resistance to various stresses, including heat, UV, and oxidation. Transcriptomic analyses showed that SscA involved the mRNA expression of cell wall organisation-related genes. Importantly, the sscA deletion mutant conidia contained an increased amount of beta-glucan and chitin compared to wild type conidia. In addition, conidial gliotoxin production was decreased in the sscA deletion strain. Overall, SscA has pleiotropic roles in conidia formation, maturation and dormancy and mycotoxin production in A. fumigatus. | Son, Ye-Eun; Han, Jiwoo; Lee, Kyung-Tae; Park, Hee-Soo | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu, South Korea; Jeonbuk Natl Univ, Korea Zoonosis Res Inst, Iksan, South Korea; Kyungpook Natl Univ, Dept Integrat Biol, Daegu, South Korea; Sch Food Sci & Biotechnol, 80 Daehak-ro,Buk-gu, Daegu 41566, South Korea | ; Park, Hee-Soo/AAC-6422-2019; Lee, Kyung-Tae/GXF-6766-2022 | 57200513491; 58776317900; 56147265800; 15751448400 | phsoo97@knu.ac.kr; | MYCOLOGY-AN INTERNATIONAL JOURNAL ON FUNGAL BIOLOGY | MYCOLOGY-UK | 2150-1203 | 2150-1211 | 15 | 2 | ESCI | MYCOLOGY | 2024 | 4.4 | 20.3 | 0 | 2025-04-16 | 2 | 0 | Aspergillus fumigatus; asexual spore; spore-specific transcription factor; C2H2 zinc finger domain; SscA; spore maturation; spore dormancy | HEAT-SHOCK PROTEINS; CELL-WALL; CANDIDA-ALBICANS; STRESS RESPONSES; VIRULENCE; IDENTIFICATION; CONIDIA | asexual spore; Aspergillus fumigatus; C<sub>2</sub>H<sub>2</sub> zinc finger domain; spore dormancy; spore maturation; spore-specific transcription factor; SscA | English | 2024 | 2024-04-02 | 10.1080/21501203.2023.2294061 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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