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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
Article Beyond CHD7 gene: unveiling genetic diversity in clinically suspected CHARGE syndrome The Verloes or Hale diagnostic criteria have been applied for diagnosing CHARGE syndrome in suspected patients. This study was conducted to evaluate the diagnostic rate of CHD7 according to these diagnostic criteria in suspected patients and also to investigate other genetic defects in CHD7-negative patients. The clinical findings and the results of genetic testing of CHD7, chromosome microarray, exome sequencing, or genome sequencing of 59 subjects were reviewed. CHD7 pathogenic variants were identified in 78% of 46 subjects who met either the Verloes or Hale diagnostic criteria and in 87% of 38 subjects who met both criteria, whereas no CHD7 variant was detected in 13 subjects who met neither criterion. Among 23 patients without the CHD7 variant, six genetic diseases were identified in 7 patients, including Wolf-Hirschhorn syndrome, 1q21 deletion syndrome, 19q13 microdeletion, and pathogenic variants in PLCB4, TRRAP, and OTX2. Based on these comprehensive analyses, the overall diagnostic rate was 73% for seven different genetic diseases. This study emphasizes the importance of comprehensive clinical and genetic evaluation in patients with clinically suspected CHARGE syndrome, recognizing the overlapping phenotypes in other rare genetic disorders. Kim, Dohyung; Yoon, Ji-Hee; Bae, Hyunwoo; Hwang, Soojin; Seo, Go Hun; Koh, June-Young; Ju, Young Seok; Do, Hyo-Sang; Kim, Soyoung; Choi, In Hee; Kim, Gu-Hwan; Kim, Ja Hye; Choi, Jin-Ho; Lee, Beom Hee Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pediat, Seoul, South Korea; Univ Ulsan, Coll Med, Med Genet Ctr, Asan Med Ctr, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Pediat, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Pediat, Seoul, South Korea; 3Billion Inc, Div Med Genet, Seoul, South Korea; Inocras Inc, Daejeon, South Korea; Asan Inst Life Sci, Asan Med Ctr, Seoul, South Korea; Univ Ulsan, Coll Med, Dept Genet Counseling, Seoul, South Korea Bae, Hyunwoo/LMN-7326-2024; Ju, Young Seok/E-1324-2012; Ju, Young/E-1324-2012 58728704100; 57226059286; 58729500000; 57463015100; 57062033100; 57214751451; 25947457600; 56067568900; 57201923858; 55513671300; 59654349600; 57218494549; 56196966800; 55513175800 mdlbh@hanmail.net; JOURNAL OF HUMAN GENETICS J HUM GENET 1434-5161 1435-232X 70 5 SCIE GENETICS & HEREDITY 2024 2.5 49.5 0 2025-05-07 0 0 MUTATIONS; ASSOCIATION; VARIANTS; SPECTRUM; DEFECTS; DISEASE; SOX2 CHARGE Syndrome; Child; Child, Preschool; DNA Helicases; DNA-Binding Proteins; Exome Sequencing; Female; Genetic Testing; Genetic Variation; Humans; Infant; Male; Phenotype; genomic DNA; CHD7 protein, human; DNA binding protein; DNA helicase; adolescent; adult; Article; chd7 gene; child; chromosome; chromosome deletion; chromosome deletion 19q13; chromosome deletion 1q21; clinical evaluation; clinical feature; cohort analysis; controlled study; female; gene; gene deletion; gene identification; gene mutation; genetic disorder; genetic screening; genetic variability; human; infant; major clinical study; male; microarray analysis; molecular diagnosis; otx2 gene; phenotype; plcb4 gene; syndrome CHARGE; trrap gene; whole exome sequencing; whole genome sequencing; Wolf Hirschhorn syndrome; diagnosis; genetic variation; genetics; preschool child; syndrome CHARGE English 2025 2025-05 10.1038/s10038-025-01325-1 바로가기 바로가기 바로가기 바로가기
Article Complete genome sequence of Pseudarthrobacter sp. NIBRBAC000502770 from coal mine of Hongcheon on Republic of Korea ObjectivesThe data were collected to obtain the complete genome sequence of Pseudarthrobacter sp. NIBRBAC000502770, isolated from the rhizosphere of Sasamorpha in a heavy metal-contaminated coal mine in Hongcheon, Republic of Korea. The objective was to explore the strain's genetic potential for plant growth promotion and heavy metal resistance, particularly arsenate and copper. The aim focused on identifying microbes that enhance plant growth in metal-tolerant environments and evaluating the strain's bioremediation and agricultural uses. This study sought key genes for bioremediation and agricultural applications in contaminated soils, aiding sustainable management and biotechnology.Data descriptionWe report the complete genome sequence of Pseudarthrobacter sp. NIBRBAC000502770, isolated from a coal mine in Hongcheon, Republic of Korea. The genome contains a chromosome (4,403,796 bp) and a plasmid (74,326 bp, named pMK-1) with 286-fold coverage. Genome annotation identified 4,209 genes, including 3,926 protein-coding genes, 51 tRNA genes, and 15 rRNA genes, with a G + C content of 66.1%. Functional analysis revealed genes related to plant growth promotion and heavy metal resistance, such as arsenate (arsR, arsC) and copper (copC, copD) resistance genes. Genes involved in auxin biosynthesis suggest potential agricultural applications. The genome and plasmid are available in GenBank (CP041198.1, CP014497.1), offering insights into bioremediation and plant growth in metal-contaminated environments. Park, Min-Kyu; Park, Yeong-Jun; Kang, Myung-Suk; Kim, Min-Ha; Kim, Soo-Young; Shin, Jae-Ho Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, NGS Core Facil, Daegu 41566, South Korea; Microbalance Co Ltd, Daegu 41566, South Korea; Natl Inst Biol Resources, Incheon 22689, South Korea shin, Jaeho/K-6792-2013 7404490480; 56275800900; 8508396800; 57220001819; 56165963800; 57224125922 pmk601313@knu.ac.kr; yjpark1091@knu.ac.kr; rosemaker@korea.kr; bistorta@korea.kr; sy7540@korea.kr; jhshin@knu.ac.kr; BMC GENOMIC DATA BMC GENOMIC DATA 2730-6844 26 1 SCIE GENETICS & HEREDITY 2024 2.5 49.5 0 2025-05-07 0 0 Whole genome sequencing; Pseudarthrobacter sp. NIBRBAC000502770; Heavy metal resistance; De novo assembly ANNOTATION De novo assembly; Heavy metal resistance; Pseudarthrobacter sp. NIBRBAC000502770; Whole genome sequencing Biodegradation, Environmental; Coal; Coal Mining; Genome, Bacterial; Metals, Heavy; Republic of Korea; Rhizosphere; Soil Microbiology; Whole Genome Sequencing; arsenic acid; auxin; copper; transfer RNA; coal; heavy metal; agricultural procedures; arsC gene; arsR gene; Article; bacterial gene; bacterial genome; bacterial strain; bacterium; bioremediation; biosynthesis; biotechnology; chromosome; coal mining; copC gene; copD gene; DNA base composition; gene sequence; genome sequence; nonhuman; plant growth; plasmid; Pseudarthrobacter; soil pollution; South Korea; sustainable agriculture; bacterial genome; coal mining; genetics; microbiology; rhizosphere; whole genome sequencing English 2025 2025-01-17 10.1186/s12863-025-01300-x 바로가기 바로가기 바로가기 바로가기
Article Effects of PM2.5 Metal Components Derived From Porcine Farm Exposure on Sperm Function in Mice This study aimed to identify the effects of major metal components present in particulate matter (PM)2.5 on the reproductive system, sperm function, and embryo development. Through intratracheal instillation, male mice were exposed to various concentrations of metal components, including calcium oxide (Ca), iron oxide (Fe), aluminum oxide (Al), zinc oxide (Zn), lead oxide (Pb), and a mixture of these metals, in PM2.5 collected from the porcine farm. After 14 days, testicular inflammation and abnormal sperm morphology were observed in the exposed mice. These results indicate that such metal exposure enhances inflammatory cytokines in the testis and oxidative stress-induced apoptosis. Moreover, the exposure influenced sperm deformation, capacitation status, testosterone levels, and testosterone biosynthesis. Importantly, embryo development was also found to be impacted due to decreased sperm fertility. This study demonstrates that major metal components of PM2.5 derived from porcine farm pose adverse effects on the male reproductive system. Kim, Chae Yeon; Kim, Chae Rim; Kim, Eungyung; Park, Kanghyun; Kim, Hyeonjin; Ma, Lei; Huang, Ke; Liu, Zhibin; Park, Junsu; Jung, Minwoong; Li, Shengqing; Wen, Weihong; Kim, Sangsik; Park, Sijun; Ryoo, Zae Young; Yi, Junkoo; Kim, Myoung Ok Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Dept Anim Sci & Biotechnol, Sangju, South Korea; Natl Inst Anim Sci, Anim Environm Div, Wanju, South Korea; Fudan Univ, Huashan Hosp, Dept Pulm & Crit Care Med, Shanghai, Peoples R China; Northwestern Polytech Univ, Inst Med Res, Xian, Peoples R China; Kyungpook Natl Univ, Dept Energy Chem Engn, Sangju, South Korea; Kyungpook Natl Univ, Sch Life Sci, FOUR KNU Creat BioRes Grp BK21, Daegu 41566, South Korea; Hankyong Natl Univ, Sch Anim Life Convergence Sci, Anseong, South Korea; Hankyong Natl Univ, Gyeonggi Reg Res Ctr, Anseong, South Korea RYOO, ZAEYOUNG/AAQ-1573-2020 57966906800; 59761066000; 57217871658; 58530860300; 57343180400; 57217867673; 59760893100; 58640210100; 57222137944; 55890039300; 53981564000; 7102171031; 56158171800; 59761932100; 59510682500; 56182537200; 8934745900 junkoo@hknu.ac.kr; ok4325@knu.ac.kr; JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY J BIOCHEM MOL TOXIC 1095-6670 1099-0461 39 5 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;TOXICOLOGY 2024 2.8 49.5 0 2025-05-07 0 0 metal; particulate matter; reproductive system; sperm; testis PARTICULATE MATTER; SILVER NANOPARTICLES; SPERMATOGENESIS; TESTOSTERONE; MOTILITY; PM10; FINE metal; particulate matter; reproductive system; sperm; testis Animals; Apoptosis; Farms; Male; Metals; Mice; Oxidative Stress; Particulate Matter; Spermatozoa; Swine; Testis; Testosterone; aluminum; aluminum oxide; bromethol; calcium; calcium oxide; iron; iron oxide; lead; lead oxide; messenger RNA; metal; reactive oxygen metabolite; testosterone; zinc; zinc oxide; metal; acrosome reaction; animal cell; animal experiment; animal tissue; apoptosis; Article; body weight; body weight change; cell death; controlled study; embryo; embryo development; epididymis; female; germ layer; in vitro study; inflammation; male; male genital system; mouse; nonhuman; orchitis; oxidative stress; particulate matter 2.5; phenotype; pig farming; PM2.5 exposure; seminiferous tubule; South Korea; sperm; sperm count; sperm function; sperm quality; spermatogenesis; spermatozoon motility; testis; testis weight; testosterone synthesis; agricultural worker; animal; drug effect; metabolism; particulate matter; pathology; pig; spermatozoon; toxicity English 2025 2025-05 10.1002/jbt.70279 바로가기 바로가기 바로가기 바로가기
Article Investigation of the Space Charge Dynamic in the Nanocomposite BaTiO3 -Doped XLPE Understanding space charge dynamics in cross-linked polyethylene (XLPE) is crucial for optimizing electrical insulation systems, preventing insulation failure, and ensuring the reliable performance of electrical equipment. Research is focused on advanced characterization techniques and predictive models to mitigate space charge effects, which are key factors in the aging and degradation of high-voltage polymer insulators. While experimental measurements are common, theoretical models are less so. This paper investigates the dynamics of space charges in barium titanate (BaTiO3)-doped XLPE nanocomposites under a continuous electric field using the bipolar charge transport model. The results show that doping with BaTiO3 significantly improves the dielectric properties of XLPE. The study presents and discusses the evolution of the electric field and charge density over time for different types of charges. Boumous, Samira; Boumous, Zouhir; Latreche, Samia; Habeeb, Majeed Ali; Fellah, Mamoun; Lamiri, Leila; Avramov, Pavel V.; El-Hiti, Gamal A. Mohamed Cherif Messaidia Univ, Lab Elect Engn & Renewable Energy, Souk Ahras, Algeria; Ferhat Abbas Setif 1Univ UFAS, Automat Lab Setif LAS, Setif, Algeria; Univ Babylon Babil, Dept Phys, Coll Educ Pure Sci, Hillah, Iraq; ABBES Laghrour Univ, Mech Engn Dept, PO 1252, Khenchela 40004, Algeria; Res Ctr Ind Technol CRTI, POB 64, Algiers 16014, Algeria; Kyungpook Natl Univ, Daegu 41566, South Korea; King Saud Univ, Dept Optometry, Coll Appl Med Sci, Riyadh 11433, Saudi Arabia ; Lamiri, Leila/HLX-5424-2023; FELLAH, Mamoun/AFL-5285-2022; El-Hiti, Gamal A./I-5942-2013; El-Hiti, Gamal/I-5942-2013; Habeeb, Majeed/R-8615-2017 57224880963; 24528251000; 57225251394; 47961729100; 55821516400; 54906176900; 7004322420; 7004126373 mamoun.fellah@yahoo.fr; JOURNAL OF ELECTRONIC MATERIALS J ELECTRON MATER 0361-5235 1543-186X 54 1 SCIE ENGINEERING, ELECTRICAL & ELECTRONIC;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED 2024 2.5 49.6 5.41 2025-05-07 5 6 Dielectric proprieties; XLPE nanocomposite; BaTiO3; bipolar charge; transport model CROSS-LINKED POLYETHYLENE; DIELECTRIC-PROPERTIES; SIMULATION BaTiO<sub>3</sub>; bipolar charge; Dielectric proprieties; transport model; XLPE nanocomposite Elastomers; Electric insulation; Hydroelasticity; Surface discharges; BaTiO 3; Bipolar charge; Crosslinked polyethylene; Dielectric propriety; Electrical insulation systems; Insulation failures; Reliable performance; Space charge dynamics; Transport modelling; XLPE nanocomposite; Crosslinking English 2025 2025-01 10.1007/s11664-024-11610-y 바로가기 바로가기 바로가기 바로가기
Article Microiontophoretic Application of Dynorphin in Dental Pain: Excitatory or Inhibitory Effects Background: The tooth exhibits increased sensitivity to noxious stimuli due to the dense innervation of thin myelinated A delta fibers and unmyelinated C fibers within the dental pulp. While prior research has identified dynorphin expression in layers I-II of the dorsal horn across the spinal cord in various pain models, its functional role in trigeminal nociception, including tooth pain, remains under- explored. This study examines the potential role of dynorphin in the nociceptive processing of dental stimuli. Methods: Experiments were performed on adult male ferrets weighing 0.9-1.4 kg. The effects of dynorphin on electrically evoked responses of tooth pulp neurons were recorded extracellularly. Results: The results demonstrated that the microiontophoretic application of dynorphin A induced excitatory and inhibitory effects on N-methyl-D-aspartate (NMDA)-evoked responses in electrically stimulated tooth pulp neurons. Specifically, dynorphin A attenuated NMDA-evoked responses in 16 out of 32 neurons by 61 +/- 6%, facilitated NMDA-evoked responses in 10 out of 32 neurons by 69 +/- 17%, and elicited mixed inhibitory and facilitatory responses in six out of 32 neurons. The inhibitory effects of dynorphin were blocked by nor-binaltorphimine, a kappa receptor antagonist, whereas the facilitatory effects were inhibited by D,L-2-amino5-phosphonovaleric acid, an NMDA receptor antagonist. Conclusion: These findings suggest that dynorphin A-induced excitatory responses are mediated by NMDA receptors, whereas its inhibitory responses are mediated through kappa opioid receptors in dental pain. Thus, dynorphin exerts diverse effects, highlighting its role in the perception and modulation of dental pain. Choi, Seung-Ho; Kim, Yu-Mi; Son, Jo-Young; Ahn, Dong-Kuk Kyungpook Natl Univ, Sch Dent, Dept Oral Physiol, 2177 Dalgubeol Daero, Daegu 41940, South Korea 59546717700; 57816812300; 57201998311; 7202706889 dkahn@knu.ac.kr; JOURNAL OF PAIN RESEARCH J PAIN RES 1178-7090 18 SCIE CLINICAL NEUROLOGY 2024 2.5 49.6 4.72 2025-05-07 2 2 dynorphin; N-methyl-D-aspartate; kappa receptor; dental pulp; analgesics LONG-LASTING ALLODYNIA; SPINAL-CORD; PERIPHERAL INFLAMMATION; MORPHINE; NMDA; ANTINOCICEPTION; EXPRESSION; RECEPTORS; NEURONS; RATS analgesics; dental pulp; dynorphin; kappa receptor; N-methyl-D-aspartate analgesic agent; chloral hydrate; dynorphin; formaldehyde; isoflurane; kappa opiate receptor; n methyl dextro aspartic acid; norbinaltorphimine; pentobarbital; protein c fos; vecuronium; anesthesia; animal experiment; animal tissue; Article; blood pressure; medical procedures; microiontophoretic; Mustela putorius furo; nerve cell; nonhuman; tooth pain; tooth pulp English 2025 2025 10.2147/jpr.s499040 바로가기 바로가기 바로가기 바로가기
Letter Clinical outcomes of percutaneous treatments for trigeminal neuralgia in multiple sclerosis: A reassessment of insights and concerns Seok, Hung Youl Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Neurol, 130 Dongdeok Ro, Daegu 41944, South Korea Seok, Hung Youl/HZI-4365-2023 24472118000 shy2354@gmail.com; CLINICAL NEUROLOGY AND NEUROSURGERY CLIN NEUROL NEUROSUR 0303-8467 1872-6968 249 SCIE CLINICAL NEUROLOGY;SURGERY 2024 1.6 49.8 0 2025-05-07 0 0 Trigeminal neuralgia; Multiple sclerosis; Percutaneous treatments; Clinical outcomes; Neurovascular conflict Clinical outcomes; Multiple sclerosis; Neurovascular conflict; Percutaneous treatments; Trigeminal neuralgia anesthesia induction; balloon occlusion; central pain syndrome; clinical assessment; clinical evaluation; clinical feature; clinical outcome; comparative study; conflict; demyelination; diagnostic accuracy; dysesthesia; facial nerve paralysis; follow up; human; hypesthesia; ICHD-3; Letter; multiple sclerosis; nuclear magnetic resonance imaging; pathophysiology; percutaneous balloon compression; personal experience; prevalence; radiofrequency; recurrent disease; symptom; therapy effect; thermocoagulation; treatment outcome; trigeminal nerve; trigeminus neuralgia; adult; adverse drug reaction; clinical outcome; drug therapy; letter; side effect; therapy; trigeminus neuralgia; unexpected outcome of drug treatment English 2025 2025-02 10.1016/j.clineuro.2025.108780 바로가기 바로가기 바로가기 바로가기
Article Impact of preoperative prognostic factors on survival outcomes in intrahepatic cholangiocarcinoma: a retrospective cohort study Purpose: This study assesses preoperative prognostic factors in intrahepatic cholangiocarcinoma (ICC) to improve risk assessment and inform clinical decisions, focusing on the role of lymph node dissection (LND). Methods: We conducted a retrospective analysis of 234 patients who underwent surgery for ICC at a single institution between 2010 and 2019. Prognostic factors affecting overall survival (OS) were identified through univariate and multivariable logistic regression analyses. Patients were categorized into high-, intermediate-, and low-risk groups based on the number of adverse prognostic factors. Survival curves were compared between the groups that underwent LND and those that did not within each risk category. Results: Of the 234 patients, 138 (59.0%) underwent LND, and 96 (41.0%) did not (non-LND). Significant prognostic factors included preoperative elevation of CEA (>5 ng/mL), CA 19-9 (>37 U/mL), tumor multiplicity, tumor size >5 cm, and extrahepatic invasion. These factors were associated with adverse OS (hazard ratio ranging from 1.69 to 2.54). High-risk patients had significantly lower median OS compared to intermediate and low-risk groups in both LND and non-LND cohorts, but no significant difference in median OS between LND and non-LND groups within each risk category was observed. Conclusion: Preoperative prognostic factors such as CEA, CA 19-9, tumor size, and multiplicity are vital for assessing patient risk in ICC. These factors guide clinical decision-making and emphasize the need fortargeted treatment strategies, including the consideration of LND, particularly in high-risk patients. The study underscores the importance of these prognostic indicators in enhancing treatment outcomes. Jeon, Hyun Jeong; Yoon, So Jeong; Chae, Ho Chang; Kim, Hyeong Seok; Shin, Sang Hyun; Han, In Woong; Heo, Jin Seok; Kim, Hongbeom Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Surg,Div Hepatobiliary Pancreat Surg, Daegu, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Surg, Div Hepatobiliary Pancreat Surg,Sch Med, 81 Irwon Ro, Seoul 06351, South Korea 57266297900; 57219111679; 58694328200; 57221454343; 36109355100; 59682837300; 7102832040; 57103962000 surgeonkhb@gmail.com; ANNALS OF SURGICAL TREATMENT AND RESEARCH ANN SURG TREAT RES 2288-6575 2288-6796 108 6 SCIE SURGERY 2024 1.6 49.8 0 0 Cholangiocarcinoma; Lymph node excision; Prognosis; Risk factors; Survival NUTRITIONAL-STATUS; HEPATECTOMY; MARKER Cholangiocarcinoma; Lymph node excision; Prognosis; Risk factors; Survival English 2025 2025-06 10.4174/astr.2025.108.6.345 바로가기 바로가기 바로가기 바로가기
Article Postoperative results after open-wedge high tibial osteotomy with lateral hinge fracture Background: Lateral hinge fracture (LHF) is a known complication of open-wedge high tibial osteotomy (OWHTO), potentially resulting in postoperative instability, displacement, loss of correction, malunion, and non-union. This study tested the hypothesis that patients who develop LHF after OWHTO can achieve clinical outcomes comparable to those without LHF, without requiring additional surgical intervention. Methods: This retrospective study included 96 patients who underwent OWHTO with a locking plate between 2019 and 2021. Postoperative radiographs and computed tomography (CT) scans identified LHF in 24 patients (25%). Lower limb alignment was assessed using whole-leg standing radiographs at 6 weeks, 3 months, 6 months, and 12 months postoperatively. Clinical outcomes were evaluated using the Hospital for Special Surgery (HSS) score, Knee Society Knee Score (KS), and Function Score (FS). Results: In patients with LHF, the mechanical axis was 59.0 +/- 7.4% at 6 weeks, 57.7 +/- 7.8% at 3 months, 55.9 +/- 9.5% at 6 months, and 53.9 +/- 12.2% at 12 months. In patients without LHF, the corresponding values were 58.5 +/- 6.1%, 57.8 +/- 6.7%, 56.7 +/- 7.0%, and 55.6 +/- 7.4%, respectively. Although the mechanical axis decreased by 5.2% in the LHF group and 2.9% in the non-LHF group by 12 months, the difference was not statistically significant (p = .219). Similarly, the longitudinal change in alignment did not differ significantly between groups (p = .743). Postoperative clinical scores improved in all patients, with no significant differences between groups regardless of LHF status. Conclusion: Patients who experienced LHF following OWHTO demonstrated comparable clinical outcomes and alignment correction to those without LHF, suggesting that LHF does not adversely affect postoperative results. Kim, Hee-June; Shin, Ji-Yeon; Lee, Hyun-Joo; Kim, Dong-Hyun; Yoon, Jong Pil; Kim, Joon-Woo; Oh, Chang-Wug; Kyung, Hee-Soo Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Orthopaed Surg, 130 Dongduk Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Daegu, South Korea Oh, Chang-Wug/AAO-4602-2021 36463735200; 55567961600; 58838750100; 57198637188; 36098548400; 22951329000; 22135834200; 59945612900 hskyung@knu.ac.kr; JOURNAL OF ORTHOPAEDIC SURGERY J ORTHOP SURG-HONG K 1022-5536 2309-4990 33 2 SCIE ORTHOPEDICS;SURGERY 2024 1.6 49.8 N/A 0 0 high tibial osteotomy; knee; lateral hinge fracture; open wedge high tibial osteotomy CORTEX DISRUPTION high tibial osteotomy; knee; lateral hinge fracture; open wedge high tibial osteotomy Adult; Aged; Bone Plates; Female; Humans; Male; Middle Aged; Osteoarthritis, Knee; Osteotomy; Postoperative Complications; Retrospective Studies; Tibia; Tibial Fractures; Treatment Outcome; adult; anterior posterior axis; Article; computer assisted tomography; female; fracture; high tibial osteotomy; human; major clinical study; male; opening wedge high tibial osteotomy; retrospective study; adverse event; aged; bone plate; diagnostic imaging; etiology; knee osteoarthritis; middle aged; osteotomy; postoperative complication; procedures; surgery; tibia; tibia fracture; treatment outcome English 2025 2025-05 10.1177/10225536251350424 바로가기 바로가기 바로가기 바로가기
Letter Upper respiratory tract infections in myasthenia gravis: Key considerations and future research directions Seok, Hung Youl Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Neurol, 130 Dongdeok Ro, Daegu 41944, South Korea Seok, Hung Youl/HZI-4365-2023 24472118000 shy2354@gmail.com; CLINICAL NEUROLOGY AND NEUROSURGERY CLIN NEUROL NEUROSUR 0303-8467 1872-6968 249 SCIE CLINICAL NEUROLOGY;SURGERY 2024 1.6 49.8 0 2025-05-07 0 0 Myasthenia gravis: Upper respiratory tract; infection; Rituximab; Vaccination; Demographic factor Demographic factor; Myasthenia gravis: Upper respiratory tract infection; Rituximab; Vaccination rituximab; rituximab; demographics; human; Letter; myasthenia gravis; upper respiratory tract infection; vaccination; aged; controlled study; drug therapy; intravenous drug administration; letter; myasthenia gravis; therapy; vaccination English 2025 2025-02 10.1016/j.clineuro.2025.108745 바로가기 바로가기 바로가기 바로가기
Article Exploration of silk-hyaluronic acid hydrogels crosslinked by the Fenton reaction Herein, HRP-free silk-HA hybrid hydrogels are generated using the Fenton reaction. The findings reveal that a higher HA concentration, at an appropriate crosslinking density, increases the random coil content while decreasing the beta-sheet content by reducing the interactions of Fe3+ ions with silk fibroin. This facilitates the formation of homogeneous hydrogel networks with enhanced optical transparency. The crosslinking strategies presented here offer a basis for the fabrication of hybrid hydrogel scaffolds based on proteins or polymers having phenolic hydroxyl moieties, without the use of HRP-catalyzed reactions, for a broad range of biomedical applications. Park, Yeong Won; Lee, Dong Yun; Choi, Jaewon Kyungpook Natl Univ, Dept Polymer Sci & Engn, Daegu 41566, South Korea 59398249100; 57211001605; 57210206972 jwchoi@knu.ac.kr; MATERIALS LETTERS MATER LETT 0167-577X 1873-4979 379 SCIE MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED 2024 2.7 50.0 0 2025-05-07 0 0 Silk fibroin; Hyaluronic acid; Hydrogel; Fenton reaction; Crosslinking Crosslinking; Fenton reaction; Hyaluronic acid; Hydrogel; Silk fibroin Crosslinking; Hyaluronic acid; Silk; Cross-linking density; Crosslinked; Fe 3+; Fenton reactions; Hyaluronic acid hydrogels; Hybrid hydrogels; Hydrogel networks; Optical transparency; Random coil; Silk fibroin; Microgels English 2025 2025-01-15 10.1016/j.matlet.2024.137682 바로가기 바로가기 바로가기 바로가기
Review Is platelet-rich plasma better than steroids as epidural drug of choice in lumbar disc disease with radiculopathy? Meta-analysis of randomized controlled trials The current meta-analysis was performed to analyze the efficacy and safety of platelet-rich plasma (PRP) as an epidural injectate, in comparison with steroids in the management of radiculopathy due to lumbar disc disease (LDD). We conducted independent and duplicate searches of the electronic databases (PubMed, Embase and Cochrane Library) in March 2024 to identify randomized controlled trials (RCTs) analyzing the efficacy of epidural PRP for pain relief in the management of LDD. Animal or in vitro studies, clinical studies without a comparator group, and retrospective or non-randomised clinical studies were excluded. Diverse post-intervention pain scores [visual analog score (VAS)] and functional scores [Oswestry Disability Index (ODI), SF-36], as reported in the reviewed studies, were evaluated. Statistical analysis was performed using STATA 17 software. 5 RCTs including 310 patients (PRP/Steroids = 153/157) were included in the analysis. The included studies compared the efficacy and safety of epidural PRP and steroids at various time-points including 1, 3, 6, 12, 24, and 48 weeks. Epidural PRP injection was found to offer comparable pain relief (VAS; WMD = -0.09, 95% CI [-0.66, 0.47], p = 0.641; I-2 = 96.72%, p < 0.001), functional improvement (ODI; WMD = 0.72, 95% CI [-6.81, 8.25], p = 0.524; I-2 = 98.73%, p < 0.001), and overall health improvement (SF-36; WMD = 1.01, 95% CI [-1.14, 3.17], p = 0.224; I-2 = 0.0%, p = 0.36) as epidural steroid injection (ESI) at all the observed time points in the included studies without any increase in adverse events or complications. Epidural administration of PRP offers comparable benefit as epidural steroid injection (ESI) in the management of radiculopathy due to LDD. The safety profile of the epidural PRP is also similar to ESI. Muthu, Sathish; Viswanathan, Vibhu Krishnan; Gangadaran, Prakash Orthopaed Res Grp, Dept Spine Surg, Coimbatore, India; Karpagam Acad Higher Educ, Fac Engn, Dept Biotechnol, Coimbatore, India; Govt Med Coll, Dept Orthopaed, Karur, India; Devadoss Hosp, Dept Orthopaed, Madurai, India; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Daegu, South Korea Viswanathan, Vibhu/Q-1461-2017; Gangadaran, Prakash/AAV-3102-2021; Muthu, Sathish/G-5756-2018 57217850874; 54421451700; 54393130400 prakashg@knu.ac.kr; EXPERIMENTAL BIOLOGY AND MEDICINE EXP BIOL MED 1535-3702 1535-3699 250 SCIE MEDICINE, RESEARCH & EXPERIMENTAL 2024 2.7 50.0 0 2025-05-07 0 1 PRP; epidural steroid; degenerative disc disease; pain relief; biologics AUTOLOGOUS CONDITIONED SERUM; LOW-BACK-PAIN; NONOPERATIVE TREATMENT; DOUBLE-BLIND; INJECTIONS; THERAPIES; EFFICACY; COMPRESSION; SCIATICA biologics; degenerative disc disease; epidural steroid; pain relief; PRP Humans; Injections, Epidural; Intervertebral Disc Degeneration; Intervertebral disc disease; Intervertebral Disc Displacement; Lumbar Vertebrae; Male; Platelet-Rich Plasma; Radiculopathy; Randomized Controlled Trials as Topic; Steroids; Treatment Outcome; biological product; steroid; steroid; adverse event; analgesia; epidural drug administration; follow up; human; in vitro study; intervertebral disk degeneration; lumbar disk degeneration; Oswestry Disability Index; outcome assessment; pain intensity; platelet-rich plasma cell; quality control; radiculopathy; randomized controlled trial (topic); risk assessment; sensitivity analysis; Short Form 36; Short Survey; systematic review; thrombocyte rich plasma; visual analog scale; complication; drug therapy; epidural drug administration; intervertebral disk degeneration; intervertebral disk disease; intervertebral disk hernia; lumbar vertebra; male; meta analysis; randomized controlled trial (topic); therapy; treatment outcome English 2025 2025-02-04 10.3389/ebm.2025.10390 바로가기 바로가기 바로가기 바로가기
Article Preoperative controlling nutritional status score for patients with medullary thyroid cancer Purpose: Medullary thyroid cancer (MTC) is aggressive in nature compared with differentiated thyroid cancer, with a poor 10-year overall survival rate. Given the effect of the immune-inflammatory system on the survival of patients with cancer, the aim of this study was to investigate the prognostic significance of the preoperative Controlling Nutritional Status (CONUT) score in patients with MTC. Methods: This multicenter, retrospective study included 221 patients with MTC who underwent thyroidectomy at four tertiary hospitals. The CONUT score was calculated for all patients using preoperative serum albumin and total cholesterol concentrations and lymphocyte counts. Patients were stratified into high and low CONUT score groups based on a cut-off score of 2. Results: Overall, 164 (74%) and 57 (26%) patients were categorized into low and high CONUT score groups, respectively. There were no significant differences in the clinicopathological characteristics, including age, sex, primary tumor size, preoperative levels of calcitonin and carcinoembryonic antigen, and neck lymph node and distant metastasis between the two groups. The 10-year disease-specific survival rate in the high CONUT score group was significantly shorter than that in the low CONUT score group (85.7% vs. 97.3%; p < 0.001). Multivariate analysis revealed that a high CONUT score was an independent prognostic factor for disease-specific survival (p = 0.008). Conclusion: The preoperative CONUT score appears to be an independent prognostic indicator in patients with surgically treated MTC, with a high score indicating a poorer prognosis. Our findings underscore the importance of preoperative nutritional and immunological assessments in MTC management. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025. Kim, Mijin; Kim, Hee Kyung; Kim, Chae A.; Jin, Meihua; Jeon, Min Ji; Kang, Ho-Cheol; Lim, Dong Jun; Kim, Eun Sook; Ahn, Byeong-Cheol; Kim, Won Gu; Kim, Bo Hyun Department of Internal Medicine, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, South Korea; Department of Internal Medicine, Chonnam National University Medical School, Gwangju, South Korea; Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea; Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea, Division of Endocrinology and Metabolism, Department of Internal Medicine, Dankook University Hospital, Dankook University College of Medicine, Cheonan, South Korea; Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea; Department of Internal Medicine, Chonnam National University Medical School, Gwangju, South Korea; Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea; Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea; Department of Nuclear Medicine, Kyungpook National University Hospital, Daegu, South Korea; Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea; Department of Internal Medicine, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, South Korea 57203466579; 59805716600; 58140001000; 57221418547; 59809081300; 8400902400; 56405024100; 58912079800; 59527540200; 59809081400; 59807954100 pons71@pusan.ac.kr; wongukim@amc.seoul.kr; Endocrine ENDOCRINE 1355-008X 1559-0100 SCIE ENDOCRINOLOGY & METABOLISM 2024 2.9 50.0 N/A 0 Controlling Nutritional Status score; Disease-specific survival; Medullary thyroid cancer; Prognostic significance English Article in press 2025 10.1007/s12020-025-04233-8 바로가기 바로가기 바로가기
Article Gossypetin Alleviates DSS-induced Colitis by Regulating COX2 and ROS-JNK Signaling Background Inflammatory Bowel Disease (IBD) represents a chronic and recurrent inflammatory condition affecting the gastrointestinal tract, with a rising global incidence. Current treatment approaches include surgery and drugs. However, surgeries are invasive procedures, while drug treatments often present with various side effects. Gossypetin, a flavonoid found abundantly in plants such as hibiscus, exhibits anti-oxidant and anti-cancer properties. However, its potential impact on IBD remains unexplored.Objective This study aimed to investigate the therapeutic potential of gossypetin on colitis.Methods We employed the DSS-induced colitis model to evaluate the therapeutic potential of gossypetin on colitis. The efficacy of gossypetin was assessed within this model using the Disease Activity Index (DAI) score and histological analysis. Additionally, we utilized qRT-PCR to measure the levels of inflammatory cytokines and Superoxide Dismutase (SOD). Immunohistochemistry confirmed the expression of tight junction markers, COX-2, and phosphorylated JNK protein, normally associated with disease progression. Furthermore, Western blot analysis was conducted to examine the SOD levels and anti-apoptotic effects of gossypetin.Results In DSS-induced colitis mice, gossypetin treatment ameliorated weight loss and reduced colon length caused by DSS treatment. Additionally, gossypetin-treated groups exhibited DAI scores and reduced histological damage. Moreover, gossypetin treatment increased tight junction expression, decreased inflammatory responses, reduced ROS levels, attenuated JNK signaling, and decreased apoptosis.Conclusion Gossypetin shows therapeutic potential for mitigating the symptoms and progression of colitis by targeting ROS-JNK signaling involved in inflammation and tissue damage. This highlights the potential of natural compounds such as gossypetin for targeted therapies with reduced side effects and improved efficacy. Kim, Hyeonjin; Kim, Eungyung; Ma, Lei; Kim, Chaeyeon; Park, Kanghyun; Liu, Zhibin; Huang, Ke; Kim, Dong Joon; Ryoo, Zae Young; Yi, Jun Koo; Sung, Yonghun; Jang, Soyoung; Kim, Myoung Ok Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Dept Anim Sci & Biotechnol, Daegu, South Korea; Kyungpook Natl Univ, Dept Dent Hyg, Daegu, South Korea; China US Henan Hormel Canc Inst, Zhengzhou, Peoples R China; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu, South Korea; Hankyong Natl Univ, Sch Anim Life Convergence Sci, Anseong, South Korea; Daegu Gyeongbuk Med Innovat Fdn DGMIF, Preclin Res Ctr, Daegu, South Korea Kim, Dong Joon/KDN-8414-2024; RYOO, ZAEYOUNG/AAQ-1573-2020 57343180400; 57217871658; 57217867673; 57966906800; 58530860300; 58640210100; 58639636600; 59903073300; 59510682500; 56182537200; 58903739800; 57139360300; 8934745900 ok4325@knu.ac.kr; jangsy@knu.ac.kr; CURRENT PHARMACEUTICAL BIOTECHNOLOGY CURR PHARM BIOTECHNO 1389-2010 1873-4316 26 5 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;PHARMACOLOGY & PHARMACY 2024 2.6 50.1 0 2025-06-11 1 1 Anti-inflammation; anti-oxidant; gossypetin; inflammatory bowel disease; DSS-induced colitis; therapeutic potential INFLAMMATORY-BOWEL-DISEASE; MICE Anti-inflammation; anti-oxidant; DSS-induced colitis; gossypetin; inflammatory bowel disease; therapeutic potential Animals; Anti-Inflammatory Agents; Apoptosis; Colitis; Colon; Cyclooxygenase 2; Dextran Sulfate; Disease Models, Animal; Flavonoids; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Reactive Oxygen Species; beta actin; caspase 3; cyclooxygenase 2; drinking water; gossypetin; interleukin 1beta; interleukin 6; occludin; protein ZO1; reactive oxygen metabolite; superoxide dismutase; tumor necrosis factor; antiinflammatory agent; dextran sulfate; flavonoid; Ptgs2 protein, mouse; reactive oxygen metabolite; animal experiment; animal model; animal tissue; apoptosis; Article; cell infiltration; controlled study; dextran sulfate sodium-induced colitis; disease exacerbation; enzyme activity; immunohistochemistry; inflammatory bowel disease; JNK signaling; male; mouse; nonhuman; oxidative stress; protein phosphorylation; real time polymerase chain reaction; reverse transcription polymerase chain reaction; upregulation; Western blotting; animal; apoptosis; C57BL mouse; colitis; colon; disease model; drug effect; drug therapy; MAPK signaling; metabolism; pathology English 2025 2025 10.2174/0113892010331882240901095733 바로가기 바로가기 바로가기 바로가기
Article Photodegradation ability of electrospun Ag–Co/polysulfone nanocomposite nanofibers against acetamiprid pesticide Non-woven neat polysulfone (PSU) and Ag–Co/PSU nanocomposite nanofibers were prepared by electrospinning process. The electrospun non-woven neat PSU and Ag–Co/PSU nanocomposite nanofibers were characterized through scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectroscopy (FTIR) and X-ray diffractometry (XRD). The SEM study presented that PSU and Ag–Co/PSU nanocomposites nanofibers were smooth, bead less, and randomly oriented. The diameter of neat PSU and Ag-Co/PSU nanocomposite nanofibers was below 800 nm. EDX spectra illustrated the elemental composition of non-woven neat PSU nanofibers and Ag–Co/PSU nanocomposite nanofibers, which showed the presence of Ag–Co NPs (nanoparticles) in the composite nanofibers. The FTIR spectrum of Ag–Co/PSU presented a peak at 710 cm−1, which might be due to the presence of Ag/Co NPs in PSU electrospun nanofibers. The photodegradation study presented that the neat PSU and Ag–Co/PSU nanocomposite nanofibers degraded about 74% and 83% acetamiprid pesticide within 5 h, respectively. It was also found that the neat PSU degraded about 20% and 67% acetamiprid pesticide while Ag–Co/PSU nanocomposite nanofibers degraded about 25% and 78% using 0.010 and 0.030 g nanofibers, respectively. Further, it was also found that the recovered PSU and Ag–Co/PSU nanocomposite electrospun nanofibers significantly degraded the acetamiprid pesticide. The photodegradation efficiency of recovered Ag–Co/PSU (47%) was higher than that of recovered neat PSU nanofibers (28%). It means that Ag–Co/PSU nanocomposite nanofibers had superior photocatalytic activity as compared to neat PSU nanofibers. Furthermore, the data were better fitted by the pseudo-first-order kinetic model compared to the pseudo-second-order kinetic model. © Iran Polymer and Petrochemical Institute 2025. Ali, Mazhar; Gul, Tamanna; Naz, Falak; Park, Soo Young; Saeed, Khalid Department of Chemistry, Bacha Khan University, KP, Charsadda, Pakistan; Department of Chemistry, Bacha Khan University, KP, Charsadda, Pakistan; Department of Chemistry, Bacha Khan University, KP, Charsadda, Pakistan; School of Applied Chemical Engineering, Polymeric Nano Materials Laboratory, Kyungpook National University, Daegu, 41566, South Korea; Department of Chemistry, Bacha Khan University, KP, Charsadda, Pakistan 58590311100; 57214320582; 57225328066; 57194041850; 56875271500 khalidsaeed@bkuc.edu.pk; Iranian Polymer Journal (English Edition) IRAN POLYM J 1026-1265 1735-5265 SCIE POLYMER SCIENCE 2024 2.8 50.5 N/A 0 Acetamiprid pesticide; Ag/Co-polysulfone; Electrospinning; Nanocomposite; Photodegradation Energy dispersive spectroscopy; Nanofibers; Scanning electron microscopy; Silver compounds; Weaving; X ray diffraction analysis; Acetamiprid pesticide; Ag/co-polysulphone; Electrospuns; Energy dispersive X ray spectroscopy; Fourier transform infrared; Nanocomposite nanofibers; Non-woven; Photo degradation; Polysulphone; Scanning electrons; Fourier transform infrared spectroscopy; Nanocomposites; Photodegradation English Article in press 2025 10.1007/s13726-025-01511-0 바로가기 바로가기 바로가기
Article Thermal behavior, flame retardant and rheological properties of low density polyethylene filled with slag In recent years, the massive discharge and irrational accumulation of slag have led to the waste of land resources and serious environmental pollution problems. In this work, to explore the potential applications of slag, it was modified with silane coupling agent 3-aminopropyltriethoxysilane (KH-550) to improve its compatibility with polymer matrix. A series of low density polyethylene (LDPE)/modified slag (MS) composites were prepared using melt blending method. The results showed that the introduction of MS significantly improved the thermal and mechanical properties of LDPE in comparison to those of its pure form. The tensile strength, tensile modulus, and Td5% of the LDPE/MS composites with 40 wt% MS content were enhanced by 58%, 113%, and 19.9 degree celsius, respectively. Furthermore, dynamic rheological analysis revealed that a higher MS filler content resulted in a higher restriction on the movement of the LDPE molecular chains. The application of slag in LDPE provides a feasible method of recycling slag and promoting sustainable development. Yan, Xin; Zhou, Yuying; Mao, Shangbin; Chen, Yujian; Liu, Chen; Wu, Hao; Wang, Hu; Zhang, He-xin; Yang, Jian-ming; Yoon, Keun-Byoung Anhui Univ Technol, Sch Chem & Chem Engn, Maanshan, Peoples R China; Kyungpook Natl Univ, Dept Polymer Sci & Engn, Daegu, South Korea Hexin, Zhang/ACI-3911-2022; Wu, Hao/KHX-9877-2024; Yang, Jianming/H-3147-2018 57222030771; 58303255000; 59306031500; 57847310400; 58606037500; 59815070500; 58744001300; 25633288200; 57192669382; 7401607550 hxzhang@ahut.edu.cn; 1085183523@qq.com; kbyoon@knu.ac.kr; IRANIAN POLYMER JOURNAL IRAN POLYM J 1026-1265 1735-5265 34 3 SCIE POLYMER SCIENCE 2024 2.8 50.5 0 2025-05-07 2 0 Slag; LDPE; Recycling; Flame retardant; Rheology DISORDER TRANSITION-TEMPERATURE; FLY-ASH; NANOCOMPOSITES; COMPOSITES; ORDER; PERFORMANCE; RESISTANCE; STABILITY; BARRIER Flame retardant; LDPE; Recycling; Rheology; Slag Bulk Density; Plastic recycling; Premixed flames; Slags; 3 aminopropyltriethoxysilane; Environmental pollution problem; Flame retardant properties; Land resources; Lower density; Melt-blending methods; Polymer matrices; Rheological property; Silane-coupling agents; Thermal behaviours; Tensile strength English 2025 2025-03 10.1007/s13726-024-01371-0 바로가기 바로가기 바로가기 바로가기
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