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| ○ | Article | Impact of Cardiovascular Risk Factors and Cardiovascular Diseases on Outcomes in Patients Hospitalized with COVID-19 in Daegu Metropolitan City | Background: Data regarding the association between preexisting cardiovascular risk factors (CVRFs) and cardiovascular diseases (CVDs) and the outcomes of patients requiring hospitalization for coronavirus disease 2019 (COVID-19) are limited. Therefore, the aim of this study was to investigate the impact of preexisting CVRFs or CVDs on the outcomes of patients with COVID-19 hospitalized in a Korean healthcare system. Methods: Patients with COVID-19 admitted to 10 hospitals in Daegu Metropolitan City, Korea, were examined. All sequentially hospitalized patients between February 15, 2020, and April 24, 2020, were enrolled in this study. All patients were confirmed to have COVID-19 based on the positive results on the polymerase chain reaction testing of nasopharyngeal samples. Clinical outcomes during hospitalization, such as requiring intensive care and invasive mechanical ventilation (MV) and death, were evaluated. Moreover, data on baseline comorbidities such as a history of diabetes, hypertension, dyslipidemia, current smoking, heart failure, coronary artery disease, cerebrovascular accidents, and other chronic cardiac diseases were obtained. Results: Of all the patients enrolled, 954 (42.0%) had preexisting CVRFs or CVDs. Among the CVRFs, the most common were hypertension (28.8%) and diabetes mellitus (17.0%). The prevalence rates of preexisting CVRF5 or CVDs increased with age (P < 0.001). The number of patients requiring intensive care (P< 0.001) and invasive MV (P< 0.001) increased with age. The in-hospital death rate increased with age (P< 0.001). Patients requiring intensive care (5.3% vs. 1.6%; P< 0.001) and invasive MV (4.3% vs. 1.7%; P< 0.001) were significantly greater in patients with preexisting CVRF5 or CVDs. In-hospital mortality (12.9% vs. 3.1%; P< 0.001) was significantly higher in patients with preexisting CVRFs or CVDs. Among the CVRFs, diabetes mellitus and hypertension were associated with increased requirement of intensive care and invasive MV and in-hospital death. Among the known CVDs, coronary artery disease and congestive heart failure were associated with invasive MV and in-hospital death. In multivariate analysis, preexisting CVRFs or CVDs (odds ratio [OR], 1.79; 95% confidence interval [CI], 1.07-3.01; P= 0.027) were independent predictors of in-hospital death after adjusting for confounding variables. Among individual preexisting CVRF or CVll components, diabetes mellitus (OR, 2.43; 95% CI, 1.51-3.90; P< 0.001) and congestive heart failure (OR, 2.43; 95% CI, 1.06-5.87; P= 0.049) were independent predictors of in-hospital death. Conclusion: Based on the findings of this study, the patients with confirmed COVID-19 with preexisting CVRFs or CVDs had worse clinical outcomes. Caution is required in dealing with these patients at triage. | Park, Bo Eun; Lee, Jang Hoon; Park, Hyuk Kyoon; Kim, Hong Nyun; Jang, Se Yong; Bae, Myung Hwan; Yang, Dong Heon; Park, Hun Sik; Cho, Yongkeun; Lee, Bong Yul; Nam, Chang Wook; Lee, Jin Bae; Kim, Ung; Chae, Shung Chull | Kyungpook Natl Univ Hosp, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Daegu Fatima Hosp, Dept Internal Med, Daegu, South Korea; Keimyung Univ, Dept Internal Med, Dongsan Med Ctr, Daegu, South Korea; Daegu Catholic Univ Hosp, Dept Internal Med, Daegu, South Korea; Yeungnam Univ Hosp, Dept Internal Med, Daegu, South Korea | ; Park, Hang-soo/AEH-1640-2022 | ljhmh75@knu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 36 | 2 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 5.354 | 27.6 | 15 | Coronavirus; SARS-CoV-2; COVID-19; Cardiovascular Risk Factors; Cardiovascular Disease; Prognosis | CLINICAL CHARACTERISTICS | English | 2021 | 2021-01-11 | 10.3346/jkms.2021.36.e15 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Impact of the COVID-19 Pandemic on the Mental Health of Adolescent Students in Daegu, Korea | Background: In February 2020, as coronavirus disease 2019 (COVID-19) spread rapidly in Daegu, South Korea, students in that region experienced many emotional difficulties. In this study, we analyzed the stress and emotional crisis experienced by students during the COVID-19 pandemic, its causative factors, and the factors that affect negative emotions. Methods: We identified the demographic information related to the experiences of unbearable stress and emotional crisis and their causal factors at three points in time: before the pandemic, during its peak, and at the time of the survey (2-3 months after the peak). In addition, we analyzed the factors related to depression and anxiety experienced by students during the COVID-19 pandemic. The Korean version of the Patient Health Questionnaire 9 and the Korean version of the Generalized Anxiety Disorder 7 was used to assess for depressive and anxiety symptoms in the subject students, respectively. Results: A total of 8,177 students participated in the analysis, with 4,072 boys (49.8%), 4,105 girls (50.2%), and 4,463 middle school students (54.6%) and 3,177 high school students (45.4%). The percentage of students who experienced unbearable stress was 9% before the COVID-19 pandemic, increased to 16% at the peak of the COVID-19 pandemic, then decreased to 12.7% at the time of the survey. Stress was experienced more by girls (18.1% versus 13.8% in boys; chi(2) = 28.159, P < 0.001) and high school students (19.0% versus 13.5% in middle school students; chi(2) = 45.437, P < 0.001). Overall, 7.6% experienced emotional crises during the COVID-19 pandemic, which was more prevalent in girls (10.1% versus 5.2% in boys; chi(2) = 71.025, P < 0.001) and in high school students (8.8% versus 6.7% in middle school students; chi(2) = 12.996, P < 0.001). Depression and anxiety was seen in 19.8% and 12.3% of students during the COVID-19 pandemic, respectively. The risk factors for depression and anxiety included unbearable stress before the COVID-19 pandemic (P < 0.001), mental health (P = 0.044), and age (P = 0.040), whereas resilience was identified as a protective factor for depression and anxiety (P = 0.001). Conclusion: Students in Daegu experienced lots of mental difficulties since the COVID-19 pandemic. It will be necessary to improve stress management and resilience to improve students' mental health in disasters such as the COVID-19 pandemic. | Lee, Hojun; Noh, Yeseul; Seo, Ji Young; Park, Sang Hee; Kim, Myoung Haw; Won, Seunghee | Keimyung Univ, Sch Med, Dept Psychiat, Daegu, South Korea; Keimyung Univ, Dept Psychiat, Dongsan Med Ctr, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Daegu Student Suicide Prevent Ctr, Daegu, South Korea; Kyungpook Natl Univ, Wee Ctr, Kyungpook Natl Univ Hosp, Chilgok Hosp, Daegu, South Korea; Daegu Metropolitan Off Educ, Dept Phys Educ & Hlth, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Psychiat, 130 Dongdeok Ro, Daegu 41944, South Korea | 57390989300; 57402735600; 57402023700; 57402023800; 57402312600; 35278955600 | wonsh864@knu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 36 | 46 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 5.354 | 27.6 | 2.98 | 2025-07-30 | 26 | 29 | COVID-19; SARS-CoV-2; Students; Adolescents; Mental Health; Daegu | ANXIETY DISORDERS; SCHOOL CLOSURE; CHILDREN; PREVALENCE | Adolescents; COVID-19; Daegu; Mental Health; SARS-CoV-2; Students | Adolescent; Affective Symptoms; Anxiety; Child; COVID-19; Depression; Female; Humans; Male; Mental Health; Republic of Korea; Retrospective Studies; SARS-CoV-2; Stress, Psychological; Students; adolescent; anxiety; child; depression; emotional disorder; female; human; male; mental health; mental stress; retrospective study; South Korea; student | English | 2021 | 2021-11-29 | 10.3346/jkms.2021.36.e321 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Intellectual Functioning of Pediatric Patients with Chronic Kidney Disease: Results from the KNOW-Ped CKD | Background: Chronic kidney disease (CKD) has a negative impact on growth and development in children and is a risk factor for neurocognitive impairment; however, there is limited research on the cognitive function of children and adolescents with CKD. This study therefore aimed to investigate the mean intelligence and risk factors for low intelligence in children and adolescents with CKD. Methods: Eighty-one patients with CKD under 18 years old were included in the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD). Participants completed either the Wechsler Intelligence Scale for Children (6-16 years), or Wechsler Adult Intelligence Scale (> 16 years). Results: The mean full-scale intelligence quotient (IQ) was 91 +/- 19; 24.7% of participants scored a full-scale IQ below 80. Participants with a short stature (height Z scores = IIIb), longer duration of CKD (>= 5 years), and those who were Medicare or Medicaid beneficiaries, had significantly lower mean full-scale IQs. Conclusion: On linear regression analysis, the association between the full-scale IQ, and longer duration of CKD and growth failure, remained significant after controlling for demographic and clinical variables. It is therefore necessary to investigate cognitive impairment in pediatric patients with CKD who exhibit growth failure or for a longer postmorbid period. It is believed that early interventions, such as kidney transplantation, will have a positive effect on IQ in children with CKD, as the disease negatively affects IQ due to poor glomerular filtration rate over time. | Kang, Na Ri; Ahn, Yo Han; Park, Eujin; Lee, Keum Hwa; Baek, Hee Sun; Kim, Seong Heon; Cho, Heeyeon; Cho, Min Hyun; Shin, Jae Il; Lee, Joo Hoon; Cheong, Hae Il; Kang, Hee Gyung; Park, Young Seo; Ha, Il-Soo; Moon, Duk-Soo; Han, Kyoung Hee | Jeju Natl Univ, Coll Med, Dept Psychiat, Jeju, South Korea; Seoul Natl Univ, Dept Pediat, Childrens Hosp, Seoul, South Korea; Hallym Univ, Dept Pediat, Kangnam Sacred Heart Hosp, Seoul, South Korea; Yonsei Univ, Dept Pediat, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Pusan Natl Univ, Dept Pediat, Childrens Hosp, Yangsan, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Pediat, Sch Med, Seoul, South Korea; Univ Ulsan, Asan Med Ctr, Dept Pediat, Coll Med,Childrens Hosp, Seoul, South Korea; Seoul Natl Univ, Med Res Ctr, Kidney Res Inst, Coll Med, Seoul, South Korea; Jeju Natl Univ, Coll Med, Dept Pediat, 15 Aran 13 Gil, Jeju 63241, South Korea; Yeungnam Univ, Coll Med, Dept Pediat, Daegu, South Korea; Hallym Univ, Dept Pediat, Sacred Heart Hosp, Anyang, South Korea | ; SHIN, JAE IL/J-6922-2017; Kim, Seong/AAD-8853-2020; Kang, Nari/JXL-3029-2024; Moon, Duk/AAY-3702-2020; Park, Eujin/AAZ-5931-2020; Lee, Seok/ABF-7548-2020 | 38662884200; 57219957477; 56194662500; 57193231590; 56689379700; 57213778393; 15724272900; 7401727726; 57964880100; 37112404100; 34567974000; 7404071546; 56701214400; 7005904938; 57052134300; 58389645900 | hansyang78@gmail.com; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 36 | 20 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 5.354 | 27.6 | 0.46 | 2025-07-30 | 4 | 4 | Intelligence; Chronic Kidney Disease; Children | COGNITIVE FUNCTION; VITAMIN-D; NEUROCOGNITIVE OUTCOMES; RENAL-TRANSPLANTATION; IRON-DEFICIENCY; CHILDREN; ADOLESCENTS; ASSOCIATION; NEUROTOXICITY; ADULTS | Children; Chronic Kidney Disease; ClinicalTrials.gov Identifier: NCT02165878; Intelligence | Adolescent; Child; Child, Preschool; Cognition; Cognition Disorders; Cohort Studies; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Humans; Intelligence; Intelligence Tests; Male; Quality of Life; Renal Insufficiency, Chronic; adolescent; child; chronic kidney failure; cognition; cognitive defect; cohort analysis; cross-sectional study; female; glomerulus filtration rate; human; intelligence; intelligence test; male; physiology; preschool child; psychology; quality of life | English | 2021 | 2021-05-24 | 10.3346/jkms.2021.36.e138 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | New-onset Nephrotic Syndrome after Janssen COVID-19 Vaccination: a Case Report and Literature Review | Various coronavirus disease 2019 (COVID-19) vaccines are being developed, which show practical preventive effects. Here, we report a 51-year-old healthy man with nephrotic syndrome secondary to minimal change disease (MCD) after Ad26.COV.2 (Janssen) vaccination. He had no comorbid disease and received Ad26.COV.2 on April 13, 2021. Seven days after vaccination, he developed edema and foamy urine. Edema rapidly aggravated with decreased urine volume. He was admitted to the hospital 28 days after vaccination, and his body weight increased by 21 kg after vaccination. His serum creatinine level was 1.54 mg/dL, and 24-h urinary protein excretion was 8.6 g/day. Kidney biopsy revealed no abnormality in the glomeruli and interstitium of the cortex and medulla under the light microscope. Electron microscopy revealed diffuse effacement of the podocyte foot processes, thus, he was diagnosed with MCD. High-dose steroid therapy was applied, and his kidney function improved three days after steroid therapy. Three weeks after steroid use, his serum creatinine decreased to 0.95 mg/dL, and spot urine protein-to-creatine decreased to 0.2 g/g. This case highlights the risk of new-onset nephrotic syndrome secondary to MCD after vectored COVID-19 vaccination. Although the pathogenesis is uncertain, clinicians need to be careful about adverse renal effects of COVID-19 vaccines. | Lim, Jeong Hoon; Han, Man Hoon; Kim, Yong Jin; Kim, Mee Seon; Jung, Hee Yeon; Choi, Ji Young; Cho, Jang Hee; Kim, Chan Duck; Kim, Yong Lim; Park, Sun Hee | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med,Div Nephrol, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Pathol, Daegu, South Korea | Kim, Yong-Lim/AGK-3172-2022; Park, Sun-Hee/LMN-0033-2024; Cho, Jang-hee/ABD-3534-2020; Kim, Yong-Jin/J-2745-2012; Lim, Jeong-Hoon/ABE-6003-2020 | 55360244300; 57194067936; 56150365500; 56123006700; 57196396467; 7501393222; 7403536291; 8558530700; 55633533600; 57808878800 | sh-park@knu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 36 | 30 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 5.354 | 27.6 | 3.79 | 2025-07-30 | 35 | 35 | Minimal Change Disease; Nephrotic Syndrome; COVID-19; Vectored Vaccine | COVID-19; Minimal Change Disease; Nephrotic Syndrome; Vectored Vaccine | COVID-19; COVID-19 Vaccines; Humans; Male; Middle Aged; Nephrosis, Lipoid; Nephrotic Syndrome; SARS-CoV-2; Vaccination; adverse event; case report; human; immunology; lipoid nephrosis; male; middle aged; nephrotic syndrome; prevention and control; vaccination | English | 2021 | 2021-08-02 | 10.3346/jkms.2021.36.e218 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Osteonecrosis of the Femoral Head: an Updated Review of ARCO on Pathogenesis, Staging and Treatment | Non-traumatic osteonecrosis of the femoral head (ONFH) usually affects adults younger than 50 years and frequently leads to femoral head collapse and subsequent arthritis of the hip. It is becoming more prevalent along with increasing use of corticosteroids for the adjuvant therapy of leukemia and other myelogenous diseases as well as management of organ transplantation. This review updated knowledge on the pathogenesis, classification criteria, staging system, and treatment of ONFH. | Hines, Jeremy T.; Jo, Woo Lam; Cui, Quanjun; Mont, Michael A.; Koo, Kyung Hoi; Cheng, Edward Y.; Goodman, Stuart B.; Ha, Yong Chan; Hernigou, Phillippe; Jones, Lynne C.; Kim, Shin Yoon; Sakai, Takashi; Sugano, Nobuhiko; Yamamoto, Takuaki; Lee, Mel S.; Zhao, Dewei; Drescher, Wolf; Kim, Tae Young; Lee, Young Kyun; Yoon, Byung Ho; Baek, Seung Hoon; Ando, Wataru; Kim, Hong Seok; Park, Jung Wee | Univ Virginia, Sch Med, Dept Orthopaed Surg, Charlottesville, VA 22908 USA; Catholic Univ Korea, Coll Med, Dept Orthopaed Surg, Seoul St Marys Hosp, Seoul, South Korea; Northwell Hlth, Dept Orthopaed Surg, Lenox Hill Hosp, New York, NY USA; Seoul Natl Univ, Bundang Hosp, Dept Orthopaed Surg, Coll Med, 82 Gumi Ro 173 Beon Gil, Seongnam 13620, South Korea; Univ Minnesota, Sch Med, Dept Orthopaed Surg, Minneapolis, MN 55455 USA; Stanford Univ, Dept Orthopaed Surg, Sch Med, Redwood City, CA USA; Chung Ang Univ, Dept Orthopaed Surg, Coll Med, Seoul, South Korea; Henri Mondor Hosp, Creteil, France; Johns Hopkins Univ, Sch Med, Dept Orthopaed Surg, Baltimore, MD USA; Kyungpook Natl Univ, Sch Med, Dept Orthoped Surg, Daegu, South Korea; Yamaguchi Univ, Dept Orthoped Surg, Grad Sch Med, Yamaguchi, Japan; Osaka Univ, Dept Orthopaed Surg, Grad Sch Med, Suita, Osaka, Japan; Fukuoka Univ, Fac Med, Dept Orthopaed Surg, Fukuoka, Japan; Kaohsiung Chang Gung Mem Hosp, Dept Orthopaed Surg, Kaohsiung, Taiwan; Dalian Univ, Dept Orthoped, Affiliated Zhongshan Hosp, Dalian, Peoples R China; RWTH Univ Hosp, Dept Orthoped Surg, Aachen, Germany; Konkuk Univ, Dept Orthopaed Surg, Coll Med, Seoul, South Korea; Ewha Womans Univ, Dept Orthopaed Surg, Coll Med, Seoul, South Korea | Koo, Kyung-Hoi/D-7053-2012; Kim, Tae/C-1272-2009; Lee, Young-Kyun/D-6175-2012; Zhao, Dewei/G-8369-2016; Ando, Wataru/MYS-6851-2025; Kim, Soo/J-5411-2012; Kim, Hyeun-Sung/H-3400-2018; Goodman, Stuart/AAZ-7499-2020 | 57202211458; 57040633000; 7103080108; 7005154075; 23488849400; 7201743350; 7402115472; 7102444576; 7005153893; 25625068200; 26663842900; 55176978800; 7101688414; 8069263600; 34971445900; 13104086400; 7004289286; 57049785800; 15044971000; 15078729100; 56232924900; 7006024884; 57026504200; 57210893279 | khkoo@snu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 36 | 24 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 5.354 | 27.6 | 12.28 | 2025-07-30 | 126 | 143 | Hip; Femoral Head; Osteonecrosis; Avascular Necrosis | TOTAL HIP-ARTHROPLASTY; CROSS-LINKED POLYETHYLENE; FAT-CELL ENLARGEMENT; NONTRAUMATIC OSTEONECROSIS; AVASCULAR NECROSIS; INTRAOSSEOUS PRESSURE; MAGNETIC-RESONANCE; CORE DECOMPRESSION; RISK-FACTORS; SYMPTOMATIC OSTEONECROSIS | Avascular Necrosis; Femoral Head; Hip; Osteonecrosis | Femur Head; Femur Head Necrosis; Glucocorticoids; Hip; Humans; Osteonecrosis; Prednisolone; glucocorticoid; prednisolone; bone necrosis; classification; femoral head; femur head necrosis; hip; human; pathology | English | 2021 | 2021-06-21 | 10.3346/jkms.2021.36.e177 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Pediatric Emergency Department Utilization and Coronavirus Disease in Daegu, Korea | Background: Limited data exist on children's utilization of the emergency department (ED) in the ongoing coronavirus disease 2019 (COVID-19) pandemic. Thus, we aimed to examine ED utilization among pediatric patients and the impact of COVID-19 in one large city affected by the outbreak. Methods: This retrospective study included data from six EDs in Daegu, Korea. We compared the demographic and clinical data of patients presenting to the ED during the COVID-19 pandemic (February 1st-June 30th 2020) with those of patients who visited the ED in this period during 2018 and 2019. Results: Fewer patients, particularly children visited the EDs during the study period in 2020 than those in the previous (2018/2019) year period: the number of adult patient decreased by 46.4% and children by 76.9%. Although the number of patients increased from the lowest point of the decrease in March 2020, the number of pediatric patients visiting the ED remained less than half (45.2%) in June 2020 compared with that of previous years. The proportion of patients with severe conditions increased in adults, infants, and school-aged children, and consequently resulted in increased ambulance use and higher hospitalization rates. Fewer infants and young children but more school-aged children visited the Ell with febrile illnesses in 2020 than in 2018/2019. Conclusion: The COVID-19 pandemic has led to a substantial decrease in pediatric Ell utilization. These findings can help reallocate human and material resources in the Ells during infectious disease outbreaks. | Jang, Kyung Mi; Ahn, Ji Young; Choi, Hee Joung; Lee, Sukhee; Kim, Dongsub; Lee, Dong Won; Choe, Jae Young | Yeungnam Univ, Yeungnam Univ Hosp, Dept Pediat, Sch Med, Daegu, South Korea; Keimyung Univ, Dept Pediat, Sch Med, Daegu, South Korea; Daegu Catholic Univ, Sch Med, Dept Emergency Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Daegu Fatima Hosp, Dept Pediat, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Emergency Med, 130 Dongdeok Ro, Daegu 41944, South Korea | ; Choe, Jae/AAJ-5209-2020; ahn, jiyoung/KSM-2201-2024 | 57203762745; 57204718185; 25937150300; 57205602138; 57205248455; 57219048083; 57023107400 | choejy@hanmail.net; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 36 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 5.354 | 27.6 | 1.72 | 2025-07-30 | 12 | 17 | COVID-19; Severe Acute Respiratory Syndrome Coronavirus 2; Children; Emergency Department | EAST RESPIRATORY SYNDROME; SYNDROME OUTBREAK; CARE UTILIZATION; IMPACT; COVID-19; MORTALITY | Children; COVID-19; Emergency Department; Severe Acute Respiratory Syndrome Coronavirus 2 | Adolescent; Adult; Child; Child, Preschool; COVID-19; Disease Outbreaks; Emergency Service, Hospital; Female; Humans; Infant; Male; Republic of Korea; SARS-CoV-2; Young Adult; adolescent; adult; child; epidemic; epidemiology; female; hospital emergency service; human; infant; male; preschool child; South Korea; young adult | English | 2021 | 2021-01-04 | 10.3346/jkms.2021.36.e11 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Correction | Pediatric Emergency Department Utilization and Coronavirus Disease in Daegu, Korea (vol 36, e11, 2021) | Jang, Kyung Mi; Ahn, Ji Young; Choi, Hee Joung; Lee, Sukhee; Kim, Dongsub; Lee, Dong Won; Choe, Jae Young | Yeungnam Univ, Sch Med, Yeungnam Univ Hosp, Dept Pediat, Daegu, South Korea; Keimyung Univ, Sch Med, Dept Pediat, Daegu, South Korea; Daegu Catholic Univ, Dept Emergency Med, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Pediat, Sch Med, Daegu, South Korea; Daegu Fatima Hosp, Dept Pediat, Daegu, South Korea; Kyungpook Natl Univ, Dept Emergency Med, Sch Med, 130 Dongdeok Ro, Daegu 41944, South Korea | Lee, Dongwon/IAU-6865-2023; ahn, jiyoung/KSM-2201-2024; Choe, Jae/AAJ-5209-2020 | 57203762745; 57204718185; 25937150300; 57205602138; 57205248455; 57219048083; 57023107400 | choejy@hanmail.net; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 36 | 3 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 5.354 | 27.6 | 0.11 | 2025-07-30 | 1 | 1 | erratum | English | 2021 | 2021-01-18 | 10.3346/jkms.2021.36.e32 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Predicting survival in heart failure: a risk score based on machine-learning and change point algorithm | Objective Machine learning (ML) algorithm can improve risk prediction because ML can select features and segment continuous variables effectively unbiased. We generated a risk score model for mortality with ML algorithms in East-Asian patients with heart failure (HF). Methods From the Korean Acute Heart Failure (KorAHF) registry, we used the data of 3683 patients with 27 continuous and 44 categorical variables. Grouped Lasso algorithm was used for the feature selection, and a novel continuous variable segmentation algorithm which is based on change-point analysis was developed for effectively segmenting the ranges of the continuous variables. Then, a risk score was assigned to each feature reflecting nonlinear relationship between features and survival times, and an integer score of maximum 100 was calculated for each patient. Results During 3-year follow-up time, 32.8% patients died. Using grouped Lasso, we identified 15 highly significant independent clinical features. The calculated risk score of each patient ranged between 1 and 71 points with a median of 36 (interquartile range: 27-45). The 3-year survival differed according to the quintiles of the risk score, being 80% and 17% in the 1st and 5th quintile, respectively. In addition, ML risk score had higher AUCs than MAGGIC-HF score to predict 1-year mortality (0.751 vs. 0.711, P < 0.001). Conclusions In East-Asian patients with HF, a novel risk score model based on ML and the new continuous variable segmentation algorithm performs better for mortality prediction than conventional prediction models. | Kim, Wonse; Park, Jin Joo; Lee, Hae-Young; Kim, Kye Hun; Yoo, Byung-Su; Kang, Seok-Min; Baek, Sang Hong; Jeon, Eun-Seok; Kim, Jae-Joong; Cho, Myeong-Chan; Chae, Shung Chull; Oh, Byung-Hee; Kook, Woong; Choi, Dong-Ju | Seoul Natl Univ, Dept Math Sci, Gwanak Ro 1, Seoul, South Korea; Seoul Natl Univ, Cardiovasc Ctr, Dept Internal Med, Div Cardiol,Bundang Hosp, Seongnam, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Chonnam Natl Univ, Heart Res Ctr, Gwangju, South Korea; Yonsei Univ, Dept Internal Med, Wonju Coll Med, Wonju, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Catholic Univ Korea, Dept Internal Med, Seoul, South Korea; Sungkyunkwan Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Asan Med Ctr, Dept Internal Med, Seoul, South Korea; Chungbuk Natl Univ, Dept Internal Med, Coll Med, Cheongju, South Korea; Kyungpook Natl Univ, Dept Internal Med, Coll Med, Daegu, South Korea; Mediplex Sejong Hosp, Dept Internal Med, Incheon, South Korea; Seoul Natl Univ, Cardiovasc Ctr, Dept Internal Med, Div Cardiol,Bundang Hosp, Gumiro 166, Gyeonggi Do, Seongnam, South Korea; MetaEyes, 41 Yonsei Ro 5Da Gil, Seoul, South Korea | Jeong, Gi/AAB-2830-2021; Oh, Byung-Hee/G-9875-2011; Choi, Dong-Ju/J-5686-2012 | 57202605224; 35799900000; 56151235500; 56150430800; 7102851884; 7405685375; 7201371594; 7004279641; 36065764100; 7401727518; 7101962036; 57216293873; 57204406090; 35274349200 | woongkook@snu.ac.kr;djchoi@snubh.org; | CLINICAL RESEARCH IN CARDIOLOGY | CLIN RES CARDIOL | 1861-0684 | 1861-0692 | 110 | 8 | SCIE | CARDIAC & CARDIOVASCULAR SYSTEMS | 2021 | 6.138 | 27.6 | 0.58 | 2025-07-30 | 9 | 9 | Heart failure; Machine learning; Grouped Lasso; Prognostic model; Mortality; Change-point analysis | OPERATING CHARACTERISTIC CURVES; MORTALITY; MODEL; HOSPITALIZATION; DISCHARGE | Change-point analysis; Grouped Lasso; Heart failure; Machine learning; Mortality; Prognostic model | Aged; Female; Heart Failure; Humans; Machine Learning; Male; Middle Aged; Predictive Value of Tests; Prognosis; Registries; Republic of Korea; Risk Assessment; Survival Rate; albumin; amiodarone; beta adrenergic receptor blocking agent; beta arrestin 1; brain natriuretic peptide; C reactive protein; creatinine; digoxin; glucose; hemoglobin; hydroxymethylglutaryl coenzyme A reductase inhibitor; loop diuretic agent; potassium; sodium; acute heart failure; acute heart infarction; adult; age; aged; algorithm; Article; atrial fibrillation; body mass; cardiac resynchronization therapy; cerebrovascular disease; cholesterol blood level; chronic kidney failure; chronic obstructive lung disease; cohort analysis; congestive cardiomyopathy; controlled study; diabetes mellitus; diastolic blood pressure; echocardiography; female; glomerulus filtration rate; heart ejection fraction; heart failure; heart rate; hospitalization; human; hypertension; ischemic heart disease; lung congestion; major clinical study; male; middle aged; mortality rate; multicenter study; New York Heart Association class; observational study; prospective study; receiver operating characteristic; survival prediction; systolic blood pressure; urea nitrogen blood level; valvular heart disease; very elderly; heart failure; machine learning; mortality; predictive value; prognosis; register; risk assessment; South Korea; survival rate | English | 2021 | 2021-08 | 10.1007/s00392-021-01870-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Prehospital Notification Using a Mobile Application Can Improve Regional Stroke Care System in a Metropolitan Area | Background: Acute ischemic stroke is a time-sensitive disease. Emergency medical service (EMS) prehospital notification of potential patients with stroke could play an important role in improving the in-hospital medical response and timely treatment of patients with acute ischemic stroke. We analyzed the effects of FASTroke, a mobile app that EMS can use to notify hospitals of patients with suspected acute ischemic stroke at the prehospital stage. Methods: We conducted a retrospective observational study of patients diagnosed with acute ischemic stroke at 5 major hospitals in metropolitan Daegu City, Korea, from February 2020 to January 2021. The clinical conditions and time required for managing patients were compared according to whether the EMS employed FASTroke app and further compared the factors by dividing the patients into subgroups according to the preregistration received by the hospitals when using FASTroke app. Results: Of the 563 patients diagnosed with acute ischemic stroke, FASTroke was activated for 200; of these, 93 were preregistered. The FASTroke prenotification showed faster door-to computed-tomography times (19 minutes vs. 25 minutes, P < 0.001), faster door-to-intravenousthrombolysis times (37 minutes vs. 48 minutes, P < 0.001), and faster door-to-endovascularthrombectomy times (82 minutes vs. 119 minutes, P < 0.001). The time was further shortened when the preregistration was conducted simultaneously by the receiving hospital. Conclusion: The FASTroke app is an easy and useful tool for prenotification as a regional stroke care system in the metropolitan area, leading to reduced transport and acute ischemic stroke management time and more reperfusion treatment. The effect was more significant when the preregistration was performed jointly. | Lee, Sang-Hun; Ryoo, Hyun Wook; Jin, Sang-Chan; Ahn, Jae Yun; Sohn, Sung-Il; Hwang, Yang-Ha; Do, Youngrok; Lee, Yoon-Soo; Kim, Jung Ho | Keimyung Univ, Dongsan Hosp, Sch Med, Dept Emergency Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Emergency Med, Daegu, South Korea; Keimyung Univ, Dongsan Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Catholic Univ Daegu, Sch Med, Dept Neurol, Daegu, South Korea; Daegu Fatima Hosp, Dept Neurosurg, Daegu, South Korea; Yeungnam Univ, Coll Med, Dept Emergency Med, Daegu, South Korea | ; Kim, Jungho/LDE-9088-2024; Ahn, Jae Yun/N-2652-2017; HWANG, Yang-Ha/F-3068-2013; Kim, Jung Ho/LDE-9088-2024 | 57210919228; 55350557500; 57205700670; 56937505400; 36479287000; 7402311308; 57203177485; 54782808500; 57205704177 | ryoo@knu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 36 | 48 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 5.354 | 27.6 | 0.23 | 2025-07-30 | 3 | 2 | Stroke; Thrombolytic Therapy; Emergency Medical Services | ACUTE ISCHEMIC-STROKE; HOSPITAL PRENOTIFICATION; EARLY MANAGEMENT; 2018 GUIDELINES; TIME; DELAYS; SCALE; MINUTES | Emergency Medical Services; Stroke; Thrombolytic Therapy | Acute Disease; Aged; Aged, 80 and over; Emergency Medical Services; Female; Fibrinolytic Agents; Humans; Ischemic Stroke; Male; Middle Aged; Mobile Applications; Odds Ratio; Registries; Retrospective Studies; Thrombectomy; Time-to-Treatment; fibrinolytic agent; acute disease; aged; brain ischemia; emergency health service; female; human; male; middle aged; mobile application; odds ratio; register; retrospective study; thrombectomy; time to treatment; very elderly | English | 2021 | 2021-12-13 | 10.3346/jkms.2021.36.e327 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Prevalence of SARS-CoV-2 Antibody in 2,935 Healthcare Workers at 6 Major Hospitals, Daegu, Korea | Background: In Korea, the first community outbreak of coronavirus disease 2019 (COVID-19) occurred in Daegu on February 18, 2020. This study was performed to investigate the prevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibodies in healthcare workers (HCWs) at 6 major hospitals in Daegu. Methods: Blood specimens of 2,935 HCWs at 6 major hospitals in Daegu from January 2021 to February 2021 were collected. Every specimen was tested for antibody against SARS-CoV-2 using both Elecsys Anti-SARS-CoV-2 electrochemiluminescence immunoassay (Roche Diagnostics, Rotkreuz, Switzerland) and R-FIND COVID-19 IgG/M/A enzyme-linked immunosorbent assay kit (SG medical Inc., Seoul, Korea) as screening tests. If 1 or more of these screening test results was positive, 2 additional antibody tests were performed using Abbott Anti-SARS-CoV-2 IgG assay (Abbott, Abbott Park, IL, USA) and cPass SARS-CoV-2 Neutralization Antibody Detection Kit (GenScript USA Inc., Piscataway, NJ, USA). If 2 or more of the total 4 test results were positive, it was determined as positive for the antibody against SARS-CoV-2. Results: According to the criteria of SARS-CoV-2 antibody positivity determination, 12 subjects were determined as positive. The overall positive rate of the SARS-CoV-2 antibody was 0.41% (12/2,935). Of the 12 subjects determined as positive, 7 were diagnosed with COVID-19, and the remaining 5 were nondiagnosed cases of COVID-19. Conclusion: In early 2021, the overall seroprevalence of SARS-CoV-2 antibody among HCW located in Daegu was 0.41%, and 0.17% excluding COVID-19 confirmed subjects. These results were not particularly high compared with the general public and were much lower than HCWs in other countries. | Kim, Yu Kyung; Minn, Dohsik; Song, Do Young; Lee, Chae Hoon; Ryoo, Nam Hee; Jeon, Chang-Ho; Song, Kyung Eun; Suh, Jang Soo; Chang, Soon Hee | Kyungpook Natl Univ, Sch Med, Dept Clin Pathol, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Seegene Med Fdn, Dept Diagnost Immunol, Seoul, South Korea; Daegu Fatima Hosp, Dept Lab Med, Daegu, South Korea; Yeungnam Univ, Coll Med, Dept Lab Med, Daegu, South Korea; Keimyung Univ, Sch Med, Dept Lab Med, Daegu, South Korea; Daegu Catholic Univ Hosp, Dept Lab Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Lab Med, Daegu, South Korea | ; Kim, Young-Il/ISS-7678-2023 | 9237571900; 57223127194; 55650920000; 38163061600; 7801573357; 35082040600; 57843936100; 57201729629; 57222602055 | marta10@hanmail.net; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 36 | 43 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 5.354 | 27.6 | 0.34 | 2025-07-30 | 3 | 3 | COVID-19; SARS-CoV-2 Antibody; Healthcare Worker; Neutralizing Antibody | COVID-19; Healthcare Worker; Neutralizing Antibody; SARS-CoV-2 Antibody | Adult; Aged; Antibodies, Neutralizing; Antibodies, Viral; Antibody Specificity; COVID-19; Enzyme-Linked Immunosorbent Assay; Female; Health Personnel; Hospitals; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Male; Middle Aged; Prevalence; Republic of Korea; SARS-CoV-2; immunoglobulin A; immunoglobulin G; immunoglobulin M; neutralizing antibody; virus antibody; adult; aged; antibody specificity; blood; diagnosis; enzyme linked immunosorbent assay; epidemiology; female; health care personnel; hospital; human; immunology; male; middle aged; prevalence; South Korea | English | 2021 | 2021-11-08 | 10.3346/jkms.2021.36.e294 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Procedural Sedation for Pediatric Upper Gastrointestinal Endoscopy in Korea | Background: Sedative upper endoscopy is similar in pediatrics and adults, but it is characteristically more likely to lead to respiratory failure. Although recommended guidelines for pediatric procedural sedation are available within South Korea and internationally, Korean pediatric endoscopists use different drugs, either alone or in combination, in practice. Efforts are being made to minimize the risk of sedation while avoiding procedural challenges. The purpose of this study was to collect and analyze data on the sedation methods used by Korean pediatric endoscopists to help physicians perform pediatric sedative upper endoscopy (PSUE). Methods: The PSUE procedures performed in 15 Korean pediatric gastrointestinal endoscopic units within a year were analyzed. Drugs used for sedation were grouped according to the method of use, and the depth of sedation was evaluated based on the Ramsay scores. The procedures and their complications were also assessed. Results: In total, 734 patients who underwent PSUE were included. Sedation and monitoring were performed by an anesthesiologist at one of the institutions. The sedative procedures were performed by a pediatric endoscopist at the other 14 institutions. Regarding the number of assistants present during the procedures, 36.6% of procedures had one assistant, 38.8% had 2 assistants, and 24.5% had 3 assistants. The average age of the patients was 11.6 years old. Of the patients, 19.8% had underlying diseases, 10.0% were taking medications such as epilepsy drugs, and 1.0% had snoring or sleep apnea history. The average duration of the procedures was 5.2 minutes. The subjects were divided into 5 groups as follows: 1) midazolam + propofol + ketamine (M + P + K): n = 18, average dose of 0.03 + 2.4 + 0.5 mg/kg; 2) M + P: n = 206, average dose of 0.06 + 2.1 mg/kg; 3) M + K: n = 267, average dose of 0.09 + 0.69 mg/kg; 4) continuous P infusion for 20 minutes: n = 15, average dose of 6.6 mg/kg; 5) M: n = 228, average dose of 0.11 mg/kg. The average Ramsay score for the five groups was 3.7, with significant differences between the groups (P < 0.001). Regarding the adverse effects, desaturation and increased oxygen supply were most prevalent in the M + K group. Decreases and increases in blood pressure were most prevalent in the M + P + K group, and bag-mask ventilation was most used in the M + K group. There were no reported incidents of intubation or cardiopulmonary resuscitation. A decrease in oxygen saturation was observed in 37 of 734 patients, and it significantly increased in young patients (P = 0.001) and when ketamine was used (P = 0.014). Oxygen saturation was also correlated with dosage (P = 0.037). The use of ketamine (P < 0.001) and propofol (P < 0.001) were identified as factors affecting the Ramsay score in the logistic regression analysis. Conclusion: Although the drug use by Korean pediatric endoscopists followed the recommended guidelines to an extent, it was apparent that they combined the drugs or reduced the doses depending on the patient characteristics to reduce the likelihood of respiratory failure. Inducing deep sedation facilitates comfort during the procedure, but it also leads to a higher risk of complications. | Lee, Yoo Min; Kang, Ben; Kim, Yu Bin; Kim, Hyun Jin; Lee, Kyung Jae; Lee, Yoon; Choi, So Yoon; Lee, Eun Hye; Yi, Dae Yong; Jang, Hyo-Jeong; Choi, You Jin; Hong, Suk Jin; Kim, Ju Young; Kang, Yunkoo; Kim, Soon Chul | Soonchunhyang Univ, Coll Med, Dept Pediat, Bucheon Hosp, Bucheon, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Ajou Univ, Dept Pediat, Sch Med, Suwon, South Korea; Chungnam Natl Univ Hosp, Dept Pediat, Daejeon, South Korea; Hallym Univ, Dept Pediat, Coll Med, Chunchon, South Korea; Korea Univ, Dept Pediat, Anam Hosp, Seoul, South Korea; Kosin Univ, Coll Med, Dept Pediat, Gospel Hosp, Busan, South Korea; Inje Univ, Haeundae Paik Hosp, Dept Pediat, Coll Med, Busan, South Korea; Eulji Univ, Nowon Eulji Med Ctr, Dept Pediat, Sch Med, Seoul, South Korea; Chung Ang Univ, Chung Ang Univ Hosp, Coll Med, Dept Pediat, Seoul, South Korea; Keimyung Univ, Dongsan Med Ctr, Dept Pediat, Sch Med, Daegu, South Korea; Inje Univ, Dept Pediat, Ilsan Paik Hosp, Goyang, South Korea; Daegu Catholic Univ, Dept Pediat, Sch Med, Daegu, South Korea; Eulji Univ, Daejeon Eulji Med Ctr, Dept Pediat, Sch Med, Daejeon, South Korea; Yonsei Univ, Dept Pediat, Wonju Coll Med, Wonju, South Korea; Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Dept Pediat, Med Sch, Jeonju, South Korea; Jeonbuk Natl Univ, Res Inst Clin Med, Biomed Res Inst, Jeonbuk Natl Univ Hosp, Jeonju, South Korea | Lee, Yong Jae/GLR-4153-2022; 康, 奔/JMQ-0812-2023; Kim, Siwon/KHX-9078-2024; lee, dong/I-9385-2017; Kim, Woo/D-2733-2015; Kim, Youngmin/C-7926-2019; Lee, Yun-Soo/AAA-7364-2022; Yi, Dae/G-1729-2014 | 55588928200; 57194823199; 57224523593; 58975661600; 57022460500; 55588945800; 57207282105; 57188855950; 57190851975; 55355948500; 56063619400; 56573097000; 57202996384; 55607051000; 36087407700 | kimsc@jbnu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 36 | 20 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 5.354 | 27.6 | 0.8 | 2025-07-30 | 6 | 7 | Children; Endoscopy; Ketamine; Midazolam; Propofol; Sedation | INDUCED SLEEP ENDOSCOPY; MIDAZOLAM-KETAMINE; ADVERSE EVENTS; ORAL MIDAZOLAM; OPERATING-ROOM; PROPOFOL; CHILDREN; ESOPHAGOGASTRODUODENOSCOPY; ANALGESIA; ANESTHESIOLOGIST | Children; Endoscopy; Ketamine; Midazolam; Propofol; Sedation | Adult; Child; Child, Preschool; Conscious Sedation; Endoscopy, Gastrointestinal; Female; Humans; Hypnotics and Sedatives; Ketamine; Male; Midazolam; Pediatrics; Propofol; Republic of Korea; hypnotic sedative agent; ketamine; midazolam; propofol; adult; child; conscious sedation; female; gastrointestinal endoscopy; human; male; organization and management; pediatrics; preschool child; procedures; South Korea | English | 2021 | 2021-05-24 | 10.3346/jkms.2021.36.e136 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Response to beta-blockers and natriuretic peptide level in acute heart failure: analysis of data from the Korean acute heart failure registry | Background To investigate the effect of beta-blockers according to NP levels and HF phenotypes because natriuretic peptide (NP) level can be used to risk-stratify HF patients regardless of left ventricular ejection fraction (LVEF). Methods Of 5,625 patients in the Korean acute heart failure registry, we included patients with LVEF and NP levels. HF phenotypes were defined as HF with reduced ejection fraction (HFrEF) (EF = 50%). Patients were further stratified by NP tertiles. Primary outcome was 5-year all-cause mortality according to beta-blocker use at discharge. Results Both B-type NP (BNP) (r = -0.279,P 0.05). After adjusting covariates, the use of beta-blockers was associated with a 38%-reduced mortality (hazard ratio: 0.62; 95% confidence interval: 0.39-0.98;P = 0.040) in HFpEF patients in the 3rd NP tertile but not in those in 1st and 2nd tertiles. Conclusions We confirm that the use of beta-blockers is beneficial in patients with HFrEF. Furthermore, we extend the benefits of beta-blockers to patients with HFpEF and high NP levels. Graphic abstract | Park, Chan Soon; Park, Jin Joo; Mebazaa, Alexandre; Lee, Hae-Young; Kim, Kye Hun; Yoo, Byung-Su; Kang, Seok-Min; Baek, Sang Hong; Jeon, Eun-Seok; Kim, Jae-Joong; Cho, Myeong-Chan; Chae, Shung Chull; Oh, Byung-Hee; Choi, Dong-Ju | Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Daejeon, South Korea; Seoul Natl Univ, Div Cardiol, Cardiovasc Ctr, Bundang Hosp, Gumiro 166, Seongnam, Gyeonggi Do, South Korea; Univ Paris Diderot, Hop Univ St Louis Lariboisiere, AP HP, UMR Inserm 942,Dept Anesthesiol & Intens Care Med, Paris, France; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Chonnam Natl Univ, Heart Res Ctr, Gwangju, South Korea; Yonsei Univ, Dept Internal Med, Wonju Coll Med, Wonju, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Catholic Univ Korea, Dept Internal Med, Seoul, South Korea; Sungkyunkwan Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Asan Med Ctr, Div Cardiol, Seoul, South Korea; Chungbuk Natl Univ, Dept Internal Med, Coll Med, Cheongju, South Korea; Kyungpook Natl Univ, Dept Internal Med, Coll Med, Daegu, South Korea; Mediplex Sejong Hosp, Dept Internal Med, Incheon, South Korea | Deniau, Benjamin/AAU-7314-2021; Choi, Dong-Ju/J-5686-2012; Oh, Byung-Hee/G-9875-2011; Jeong, Gi/AAB-2830-2021 | 57198830480; 35799900000; 57210091243; 56151235500; 56150430800; 7102851884; 7405685375; 7201371594; 7004279641; 36065764100; 7401727518; 7101962036; 57216293873; 35274349200 | djchoi@snubh.org; | CLINICAL RESEARCH IN CARDIOLOGY | CLIN RES CARDIOL | 1861-0684 | 1861-0692 | 110 | 9 | SCIE | CARDIAC & CARDIOVASCULAR SYSTEMS | 2021 | 6.138 | 27.6 | 0.19 | 2025-07-30 | 1 | 2 | Beta-blockers; Heart failure; Natriuretic peptide; Mortality | PRESERVED EJECTION FRACTION; NT-PROBNP; PROGNOSTIC VALUE; SPIRONOLACTONE; DIAGNOSIS; OUTCOMES; ASSOCIATION; MECHANISMS; MORTALITY; ENALAPRIL | Beta-blockers; Heart failure; Mortality; Natriuretic peptide | Acute Disease; Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Female; Follow-Up Studies; Heart Failure; Humans; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Registries; Republic of Korea; Risk Factors; Stroke Volume; Ventricular Function, Left; amino terminal pro brain natriuretic peptide; beta adrenergic receptor blocking agent; thiazide diuretic agent; beta adrenergic receptor blocking agent; brain natriuretic peptide; peptide fragment; pro-brain natriuretic peptide (1-76); acute heart failure; adult; Article; cohort analysis; controlled study; female; heart ejection fraction; heart failure; heart failure with reduced ejection fraction; human; major clinical study; male; middle aged; mortality; multicenter study; propensity score; retrospective study; survival rate; acute disease; aged; follow up; heart failure; heart left ventricle function; heart stroke volume; metabolism; pathophysiology; physiology; register; risk factor; South Korea; very elderly | English | 2021 | 2021-09 | 10.1007/s00392-020-01689-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Revised Korean Antiviral Guideline Reduces the Hepatitis B-related Hepatocellular Carcinoma Risk in Cirrhotic Patients | Background: Since September 2015, the initiation of antiviral therapy (AVT) for patients with chronic hepatitis B (CHB)-related cirrhosis has been reimbursed according to the revised Korean Association for the Study of Liver (KASL) guideline, if the patient had hepatitis B virus DNA level >= 2,000 IU/L, regardless of aminotransferase or alanine aminotransferase levels. This study investigated whether the KASL guideline implementation reduced the risk of CHB-related hepatocellular carcinoma (HCC) in patients with cirrhosis in South Korea. Methods: A total of 429 patients with CHB-related cirrhosis who initiated AVT between 2014 and 2016 were recruited. The risk of HCC development was compared between patients who initiated AVT before and after September 2015 (pre-guideline [n = 196, 45.7%] vs. post-guideline implementation [n = 233, 54.3%]). Results: Univariate analysis showed that AVT initiation before guideline implementation, older age, male gender, and diabetes significantly predicted increased risk of HCC development (all P < 0.05). Subsequent multivariate analysis showed that AVT initiation before guideline implementation (HR = 1.941), older age (HR = 5.762), male gender (HR = 2.555), and diabetes (HR = 1.568) independently predicted increased risk of HCC development (all P < 0.05). Additionally, multivariate analysis showed that AVT initiation before guideline implementation (HR = 2.309), male gender (HR = 3.058), and lower platelet count (HR = 0.989) independently predicted mortality (P < 0.05). The cumulative incidences of HCC and mortality were significantly higher in patients who initiated AVT before guideline implementation than in those who initiated AVT after guideline implementation (all P < 0.05, log-rank test). Conclusion: The prognosis of patients with CHB-related cirrhosis who initiated AVT improved after guideline implementation according to the revised KASL guideline. | Kim, David Sooik; Park, Soo Young; Kim, Beom Kyung; Park, Jun Yong; Kim, Do Young; Han, Kwang-Hyub; Lee, Yu Rim; Tak, Won Young; Kweon, Young Oh; Jung, Inkyung; Han, Minkyung; Kim, Eun Hwa; Ahn, Sang Hoon; Kim, Seung Up | Yonsei Univ, Inst Gastroenterol, Dept Internal Med, Coll Med, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Korea, South Korea; Severance Hosp, Yonsei Liver Ctr, Seoul, South Korea; Yonsei Univ, Dept Biomed Syst Informat, Div Biostat, Coll Med, Seoul, South Korea; Yonsei Univ, Dept Biomed Syst Informat, Biostat Collaborat Unit, Coll Med, Seoul, South Korea | park, soo-young/N-3170-2017; Kim, Dong/F-4608-2014; Kim, Jinwoo/NQF-6310-2025; SANG-HOON, AHN/AAV-2600-2020; Ahn, Sang Hoon/AFM-2603-2022; Kim, Jin Hyoung/AAE-8050-2019; Jung, Inkyung/Q-2018-2016; Park, Jun/H-7127-2019; Kim, Nayoung/J-5387-2012; Kim, Sun/L-4239-2013 | 57209330152; 57191674344; 35302925200; 47861376300; 56119929100; 7402963689; 57194094753; 7004074582; 7004694832; 16039030000; 55322884600; 57201077476; 7401989551; 54933821200 | ksukorea@yuhs.ac; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 36 | 16 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 5.354 | 27.6 | 0.34 | 2025-07-30 | 3 | 4 | Hepatitis B; Antiviral Therapy; Hepatocellular Carcinoma; Management; Guideline | MANAGEMENT; DISEASE | Antiviral Therapy; Guideline; Hepatitis B; Hepatocellular Carcinoma; Management | Antiviral Agents; Carcinoma, Hepatocellular; Female; Guidelines as Topic; Hepatitis B virus; Hepatitis B, Chronic; Humans; Incidence; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Republic of Korea; Risk Factors; Treatment Outcome; antivirus agent; chronic hepatitis B; complication; female; genetics; Hepatitis B virus; human; incidence; isolation and purification; liver cell carcinoma; liver cirrhosis; liver tumor; male; middle aged; practice guideline; risk factor; South Korea; treatment outcome; virology | English | 2021 | 2021-04-26 | 10.3346/jkms.2021.36.e105 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Severe Disease Activity Based on the Paris Classification Is Associated with the Development of Extraintestinal Manifestations in Korean Children and Adolescents with Ulcerative Colitis | Background: There are limited data regarding the extraintestinal manifestations (EIMs) associated with pediatric inflammatory bowel disease (IBD) in Korea. We aimed to investigate the clinical features and factors associated with the development of EIMs in Korean children and adolescents with IBD. Methods: This multicenter, retrospective study was conducted from 2010 to 2017. Baseline clinicodemographic, laboratory findings, disease activity, disease phenotypes, and EIMs were investigated. Results: A total of 172 patients were included. One-hundred thirty-seven (79.7%) had Crohn's disease (CD), and 35 (20.3%) had ulcerative colitis (UC). EIMs occurred in 42 patients (24.4%). EIMs developed in 34/137 diagnosed with CD (24.8%), and in 8/35 diagnosed with UC (22.9%), during a median follow-up duration of 3.2 (interquartile range, 1.9-5.4) years for CD and 3.0 (1.0-4.0) years for UC, respectively. Arthritis/arthralgia was most commonly observed (n = 15, 35.7%), followed by stomatitis/oral ulcer (n = 10, 23.8%), hepatitis (n = 5, 11.9%), nephritis (n = 4, 9.5%), pancreatitis (n = 2, 4.8%), erythema nodosum (n = 2, 4.8%), pyoderma gangrenosum (n = 1, 2.4%), primary sclerosing cholangitis (n = 1, 2.4%), uveitis (n = 1, 2.4%), and ankylosing spondylitis (n = 1, 2.4%). A significant difference in disease severity based on the Paris classification (P = 0.011) and ESR at diagnosis (P = 0.043) was observed between the EIM positive and negative group in patients with UC. According to logistic regression analyses, S1 disease severity based on the Paris classification was the only factor that was significantly associated with the development of EIMs (odds ratio, 16.57; 95% confidence interval, 2.18-287.39; P = 0.017). Conclusion: Severe disease activity based on the Paris classification in pediatric patients with UC was significantly associated with EIM development. As disease severity in the Paris classification is a dynamic parameter, treatment should be focused on disease control to minimize the occurrence of EIMs in Korean children and adolescents with UC. | Jang, Hyo-Jeong; Suh, Hyo Rim; Choi, Sujin; Hong, Suk Jin; Cho, Seung-Man; Choi, Kwang-Hae; Choe, Byung -Ho; Kang, Ben | Keimyung Univ, Dept Pediat, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Pediat, Sch Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Daegu Catholic Univ, Dept Pediat, Sch Med, Daegu, South Korea; Dongguk Univ, Dept Pediat, Sch Med, Gyeongju, South Korea; Yeungnam Univ, Dept Pediat, Sch Med, Daegu, South Korea | ; 康, 奔/JMQ-0812-2023; Choe, Byung-Ho/KSM-6251-2024 | 55355948500; 57203059359; 57223972405; 56573097000; 35168810700; 55040976900; 57574977300; 57194823199; 57327995700 | benkang@knu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 36 | 44 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 5.354 | 27.6 | 0.69 | 2025-07-30 | 5 | 7 | Extraintestinal Manifestation; Crohn's Disease; Ulcerative Colitis; Pediatric; Paris Classification | INFLAMMATORY-BOWEL-DISEASE; CROHNS-DISEASE; ACTIVITY INDEX; DIAGNOSIS; VALIDATION | Crohn’s Disease; Extraintestinal Manifestation; Paris Classification; Pediatric; Ulcerative Colitis | Adolescent; Arthritis; Child; Colitis, Ulcerative; Crohn Disease; Female; Humans; Logistic Models; Male; Odds Ratio; Pyoderma Gangrenosum; Republic of Korea; Retrospective Studies; Severity of Illness Index; Stomach Ulcer; adolescent; arthritis; child; classification; complication; Crohn disease; female; human; male; odds ratio; pathology; pyoderma gangrenosum; retrospective study; severity of illness index; South Korea; statistical model; stomach ulcer; ulcerative colitis | English | 2021 | 2021-11-15 | 10.3346/jkms.2021.36.e278 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Severe Phenotype of Non-alcoholic Fatty Liver Disease in Pediatric Patients with Subclinical Hypothyroidism: a Retrospective Multicenter Study from Korea | Background: It is uncertain whether non-alcoholic fatty liver disease (NAFLD) is associated with subclinical hypothyroidism (SH) in pediatric patients. The purpose of this study was to investigated the prevalence and related factors of SH in pediatric patients with NAFLD. We also evaluate the association between liver fibrosis and SH. Methods: We retrospectively reviewed medical records for patients aged 4 to 18 years who were diagnosed with NAFLD and tested for thyroid function from January 2015 to December 2019 at 10 hospitals in Korea. Results: The study included 428 patients with NAFLD. The prevalence of SH in pediatric NAFLD patients was 13.6%. In multivariate logistic regression, higher levels of steatosis on ultrasound and higher aspartate aminotransferase to platelet count ratio index (APRI) score were associated with increased risk of SH. Using receiver operating characteristic curves, the optimal cutoff value of the APRI score for predicting SH was 0.6012 (area under the curve, 0.67; P < 0.001; sensitivity 72.4%, specificity 61.9%, positive predictive value 23%, and negative predictive value 93.5%). Conclusion: SH was often observed in patients with NAFLD, more frequently in patients with more severe liver damage. Thyroid function tests should be performed on pediatric NAFLD patients, especially those with higher grades of liver steatosis and fibrosis. | Choi, So Yoon; Yi, Dae Yong; Kim, Soon Chul; Kang, Ben; Choe, Byung-Ho; Lee, Yoon; Lee, Yoo Min; Lee, Eun Hye; Jang, Hyo-Jeong; Choi, You Jin; Kim, Hyun Jin | Kosin Univ, Kosin Gospel Hosp, Dept Pediat, Coll Med, Busan, South Korea; Inje Univ, Haeundae Paik Hosp, Dept Pediat, Coll Med, Busan, South Korea; Chung Ang Univ, Chung Ang Univ Hosp, Coll Med, Dept Pediat, Seoul, South Korea; Jeonbuk Natl Univ, Dept Pediat, Med Sch & Hosp, Jeonju, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Korea Univ, Dept Pediat, Anam Hosp, Seoul, South Korea; Soonchunhyang Univ, Bucheon Hosp, Dept Pediat, Coll Med, Bucheon, South Korea; Eulji Univ, Nowon Eulji Med Ctr, Dept Pediat, Sch Med, Seoul, South Korea; Keimyung Univ, Dongsan Med Ctr, Dept Pediat, Sch Med, Daegu, South Korea; Inje Univ, Coll Med, Ilsan Paik Hosp, Dept Pediat, Gimhae, South Korea; Chungnam Natl Univ Hosp, Dept Pediat, 282 Munhwa Ro, Daejeon 35015, South Korea | Choe, Byung-Ho/KSM-6251-2024; 康, 奔/JMQ-0812-2023; Kim, Siwon/KHX-9078-2024; Lee, Yong Jae/GLR-4153-2022; Lee, Yun-Soo/AAA-7364-2022; Yi, Dae/G-1729-2014 | 57207282105; 57190851975; 36087407700; 57194823199; 57574977300; 55588945800; 55588928200; 57188855950; 55355948500; 56063619400; 58975661600 | tai832@cnuh.co.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 36 | 20 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 5.354 | 27.6 | 0.34 | 2025-07-30 | 5 | 4 | Non-alcoholic Fatty Liver Disease; Subclinical Hypothyroidism; Liver Steatosis; Liver Fibrosis | ASSOCIATION; THYROTROPIN; DIAGNOSIS; CHILDREN; OBESITY; INDEX; NAFLD | Liver Fibrosis; Liver Steatosis; Non-alcoholic Fatty Liver Disease; Subclinical Hypothyroidism | Adolescent; Child; Fatty Liver; Female; Humans; Hypothyroidism; Liver Cirrhosis; Male; Non-alcoholic Fatty Liver Disease; Prevalence; Republic of Korea; Retrospective Studies; Thyroid Function Tests; adolescent; child; clinical trial; fatty liver; female; human; hypothyroidism; liver cirrhosis; male; multicenter study; nonalcoholic fatty liver; prevalence; retrospective study; South Korea; thyroid function test | English | 2021 | 2021-05-24 | 10.3346/jkms.2021.36.e137 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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