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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Assessing the effects of climate change on flood inundation in the lower Mekong Basin using high-resolution AGCM outputs | Climate change currently affects the resilience and aquatic ecosystem. Climate change alters rainfall patterns which have a great impact on river flow. Annual flooding is an important hydrological characteristic of the Mekong River Basin (MRB) and it drives the high productivity of the ecosystem and biodiversity in the Tonle Sap floodplain and the Mekong Delta. This study aims to assess the impacts of climate change on river flow in the MRB and flood inundation in the Lower Mekong Basin (LMB). The changing impacts were assessed by a two-dimensional rainfall-runoff and inundation model (RRI model). The present climate (1979-2003) and future projected climate (2075-2099) datasets from MRI-AGCM3.2H and MRI-AGCM3.2S models were applied with a linear scaling bias correction method before input into the RRI model. The results of climate change suggested that flood magnitude in the LMB will be severer than the present climate by the end of the twenty-first century. The increment of precipitation between 6.6 and 14.2% could lead to increase extreme flow (Q(5)) 13-30%, peak inundation area 19-43%, and peak inundation volume 24-55% in the LMB for ranging of Representative Concentration Pathways (RCP) and sea surface temperature (SST) scenarios while there is no significant change on peak flood timing. | Try, Sophal; Tanaka, Shigenobu; Tanaka, Kenji; Sayama, Takahiro; Lee, Giha; Oeurng, Chantha | Kyoto Univ, Grad Sch Engn, Uji 6110011, Japan; Kyoto Univ, Disaster Prevent Res Inst, Uji 6110011, Japan; Kyungpook Natl Univ, Dept Construct & Disaster Prevent Engn, Gyeongsangdaero 2559, Sangju 742711, South Korea; Inst Technol Cambodia, Fac Hydrol & Water Resource Engn, Russian Conf Blvd, Phnom Penh 12156, Cambodia | ; Try, Sophal/HJP-8855-2023; Sayama, Takahiro/IRZ-9977-2023 | 57196045412; 7405552751; 7406925763; 7004375739; 35069799400; 36483430800 | trysophal001@gmail.com; | PROGRESS IN EARTH AND PLANETARY SCIENCE | PROG EARTH PLANET SC | 2197-4284 | 7 | 1 | SCIE | GEOSCIENCES, MULTIDISCIPLINARY | 2020 | 3.604 | 32.3 | 1.31 | 2025-06-25 | 35 | 36 | Climate change; River discharge; Flood inundation; Lower Mekong Basin | TONLE-SAP LAKE; TEMPERATURE; PULSE; PRECIPITATION; UNCERTAINTY; SCENARIOS; ECOSYSTEM; RUNOFF; IMPACT; CMIP5 | Climate change; Flood inundation; Lower Mekong Basin; River discharge | English | 2020 | 2020-07-29 | 10.1186/s40645-020-00353-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | An integrated 1D breathing lung simulation with relative hysteresis of airway structure and regional pressure for healthy and asthmatic human lungs | This study aims to develop a one-dimensional (1D) computational fluid dynamics (CFD) model with dynamic airway geometry that considers airway wall compliance and acinar dynamics. The proposed 1D model evaluates the pressure distribution and the hysteresis between the pressure and tidal volume (V-tidal) in the central and terminal airways for healthy and asthmatic subjects. Four-dimensional CT images were captured at 11-14 time points during the breathing cycle. The airway diameter and length were reconstructed using a volume-filling method and a stochastic model at respective time points. The obtained values for the airway diameter and length were interpolated via the Akima spline to avoid unboundedness. A 1D energy balance equation considering the effects of wall compliance and parenchymal inertance was solved using the efficient aggregationbased algebraic multigrid solver, a sparse matrix solver, reducing the computational costs by around 90% when compared with the generalized minimal residual solver. In the Vtidal versus displacement in the basal direction (z-coordinate), the inspiration curve was lower than the expiration curve, leading to relative hysteresis. The dynamic deformation model was the major factor influencing the difference in the workload in the central and terminal airways. In contrast, wall compliance and parenchymal inertance appeared only marginally to affect the pressure and workload. The integrated 1D model mimicked dynamic deformation by predicting airway diameter and length at each time point, describing the effects of wall compliance and parenchymal inertance. This computationally efficient model could be utilized to assess breathing mechanism as an alternative to pulmonary function tests. NEW & NOTEWORTHY This study introduces a one-dimensional (1D) computational fluid dynamics (CFD) model mimicking the realistic changes in diameter and length in whole airways and reveals differences in lung deformation between healthy and asthmatic subjects. Utilizing computational models, the effects of parenchymal inertance and airway wall compliance are investigated by changing ventilation frequency and airway wall elastance, respectively. | Yoon, Sujin; Tran Minh Tam; Rajaraman, Prathish K.; Lin, Ching-Long; Tawhai, Merryn; Hoffman, Eric A.; Choi, Sanghun | Kyungpook Natl Univ, Sch Mech Engn, Daegu, South Korea; Univ Iowa, IIHR Hydrosci & Engn, Iowa City, IA USA; Univ Iowa, Dept Mech Engn, Iowa City, IA 52242 USA; Univ Iowa, Dept Biomed Engn, Iowa City, IA 52242 USA; Univ Iowa, Dept Radiol, Iowa City, IA 52242 USA; Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA; Univ Auckland, Auckland Bioengn Inst, Auckland, New Zealand | ; Choi, Sanghun/AGS-7430-2022 | 57210139250; 57219429275; 59266216700; 8923593300; 6602735857; 58000586800; 55847101000 | s-choi@knu.ac.kr; | JOURNAL OF APPLIED PHYSIOLOGY | J APPL PHYSIOL | 8750-7587 | 1522-1601 | 129 | 4 | SCIE | PHYSIOLOGY;SPORT SCIENCES | 2020 | 3.532 | 32.4 | 0.72 | 2025-06-25 | 15 | 13 | 4D CT scans; dynamic deforming model; lung hysteresis; wall compliance and parenchymal inertance | HYPERPOLARIZED HE-3; FLOW OBSTRUCTION; VENTILATION; MODEL; REGISTRATION; DEFORMATION; RESISTANCE; MECHANICS; IMAGES | Asthma; Computer Simulation; Humans; Lung; Models, Biological; Respiration; Respiratory Function Tests; asthma; biological model; breathing; computer simulation; human; lung; lung function test | English | 2020 | 2020-10 | 10.1152/japplphysiol.00176.2020 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Attenuation of Inflammatory Symptoms by Icariside B2 in Carrageenan and LPS-Induced Inflammation Models via Regulation of MAPK/NF-κB Signaling Cascades | Prolonged inflammatory responses can lead to the development of several chronic diseases, such as autoimmune disorders and the development of natural therapeutic agents is required. A murine model was used to assess the anti-inflammatory effects of the megastigmane glucoside, icariside B2 (ICSB), and the assessment was carried out in vitro, and in vivo. The in vitro anti-inflammatory effects of ICSB were tested using LPS-stimulated BV2 cells, and the protein expression levels of inflammatory genes and cytokines were assessed. Mice were subcutaneously injected with 1% carrageenan (CA) to induce acute phase inflammation in the paw. Inflammation was assessed by measuring paw volumes hourly; subsequently, the mice were euthanized and the right hind paw skin was expunged and processed for reverse transcription-polymerase chain reaction (RT-PCR) and Western blot analyses. ICSB inhibits LPS-stimulated nitric oxide (NO) and prostaglandin E2 (PGE(2)) generation by reducing the expression of inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2). ICSB also inhibits the COX-2 enzyme with an IC50 value of 7.80 +/- 0.26 mu M. Molecular docking analysis revealed that ICSB had a strong binding affinity with both murine and human COX-2 proteins with binding energies of -8 kcal/mol and -7.4 kcal/mol, respectively. ICSB also reduces the manifestation of pro-inflammatory cytokines, such as TNF-alpha, IL-6, and IL-1 beta, at their transcriptional and translational level. ICSB hinders inhibitory protein kappa B alpha (I kappa B alpha) phosphorylation, thereby terminating the nuclear factor kappa-light-chain-enhancer of activated B cell (NF-kappa B) nuclear translocation. ICSB also represses the mitogen-activated protein kinases (MAPKs) signaling pathways. ICSB (50 mg/kg) showed an anti-edema effect in CA-induced mice and suppressed the CA-induced increases in iNOS and COX-2 protein levels. ICSB attenuated inflammatory responses by downregulating NF-kappa B expression through interference with extracellular signal-regulated kinase (ERK) and p38 phosphorylation, and by modulating the expression levels of iNOS, COX-2, TNF-alpha, IL-1 beta, and IL-6. | Alam, Md Badrul; Kwon, Yoon-Gyung; Simu, Shakina Yesmin; Shahriyar, Sk Abrar; Lee, Sang Han | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Grad Sch, Daegu 41566, South Korea; Kyungpook Natl Univ, Inner Beauty Antiaging Ctr, Food & Bioind Res Inst, Daegu 41566, South Korea; Ajou Univ, Dept Brain Sci, Sch Med, Suwon 16499, South Korea; Ajou Univ, Grad Sch, Biomed Sci, Sch Med, Suwon 16499, South Korea; Kyungpook Natl Univ, Knu BnC, Daegu 41566, South Korea | Lee, Seung Eun/ABG-1607-2021; Alam, Md Badrul/AAK-7176-2021 | 56706777100; 59102005400; 56676236800; 57204422642; 57221453703 | mbalam@knu.ac.kr;yongyeung@knu.ac.kr;simu90@aumc.ac.kr;sksy.kmu@gmail.com;sang@knu.ac.kr; | BIOMOLECULES | BIOMOLECULES | 2218-273X | 10 | 7 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2020 | 4.879 | 32.4 | 0.4 | 2025-06-25 | 16 | 14 | anti-inflammatory effects; icariside B2; NF-kappa B signaling; MAP-kinase | ANTIINFLAMMATORY ACTIVITY; INDUCED EDEMA; LUNG INJURY; LIGNAN; CONSTITUENTS; INHIBITION; PATHWAY; PAW; L. | Anti-inflammatory effects; Icariside B2; MAP-kinase; NF-κB signaling | Animals; Anti-Inflammatory Agents; Carrageenan; Cyclohexanones; Disease Models, Animal; Edema; Epimedium; Gene Expression Regulation; Glucosides; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; NF-kappa B; Norisoprenoids; Phosphorylation; Plant Extracts; buffer; carrageenan; cyclooxygenase 2; edetic acid; glucoside; hematin; icariside b2; immunoglobulin enhancer binding protein; indometacin; inducible nitric oxide synthase; interleukin 1beta; interleukin 6; mitogen activated protein kinase; nitric oxide; phenol; prostaglandin E2; synaptophysin; tumor necrosis factor; unclassified drug; vascular cell adhesion molecule 1; antiinflammatory agent; carrageenan; cyclohexanone derivative; glucoside; immunoglobulin enhancer binding protein; lipopolysaccharide; megastigmane; norisoprenoid; plant extract; animal cell; animal experiment; animal model; antiinflammatory activity; Article; attenuation; BV-2 cell line; carrageenan-induced inflammation; cell viability; controlled study; enzyme activity; enzyme linked immunosorbent assay; Epimedium; Epimedium koreanum nakai; fluorescence microscopy; gene expression; genetic transfection; high performance liquid chromatography; IC50; immunofluorescence test; lipopolysaccharide-induced inflammation; luciferase assay; MAPK signaling; molecular docking; mouse; MTT assay; nonhuman; paw edema; protein expression; protein phosphorylation; reverse transcription polymerase chain reaction; signal transduction; software; Western blotting; X ray crystallography; animal; chemistry; conformation; disease model; drug effect; edema; gene expression regulation; MAPK signaling; metabolism; molecular model; phosphorylation | English | 2020 | 2020-07 | 10.3390/biom10071037 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Cerevisterol Alleviates Inflammation via Suppression of MAPK/NF-κB/AP-1 and Activation of the Nrf2/HO-1 Signaling Cascade | As part of our continuous effort to find potential anti-inflammatory agents from endophytic fungi, a Fusarium solani strain, isolated from the plant Aponogeton undulatus Roxb., was investigated. Cerevisterol (CRVS) was identified from endophytic fungi, a Fusarium solani strain, and moreover exhibited anti-inflammatory activity. However, the underlying mode of action remains poorly understood. The aim of this study is to reveal the potential mechanisms of CRVS against inflammation on a molecular level in LPS-activated RAW 264.7 peritoneal macrophage cells. CRVS was isolated from F. solani and characterized based on spectral data analysis. The MTT assay was performed to measure cell viability in CRVS-treated macrophages. Anti-inflammatory activity was assessed by measurement of nitric oxide (NO) and prostaglandin E-2 (PGE(2)) levels, as well as the production of various cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and -6 (IL-6) in LPS-stimulated macrophages. RT-PCR and immunoblotting analyses were done to examine the expression of various inflammatory response genes. A reporter gene assay was conducted to measure the level of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) and activator protein-1 (AP-1) transactivation. CRVS suppresses the LPS-induced production of NO and PGE(2), which is a plausible mechanism for this effect is by reducing the expression of iNOS and COX-2. CRVS also decreases the expression of pro-inflammatory cytokines, such as TNF-alpha, IL-6, and IL-1 beta. CRVS halted the nuclear translocation of NF-kappa B by blocking the phosphorylation of inhibitory protein kappa B alpha (I kappa B alpha) and suppressing NF-kappa B transactivation. The mitogen-activated protein kinases (MAPK) signaling pathways are also suppressed. CRVS treatment also inhibited the transactivation of AP-1 and the phosphorylation of c-Fos. Furthermore, CRVS could induce the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) by down-regulating Kelch-like ECH-associated protein 1 (Keap-1) and up-regulating hemeoxygenases-1 (HO-1) expression. The results suggest that CRVS acts as a natural agent for treating inflammatory diseases by targeting an MAPK, NF-kappa B, AP-1, and Nrf2-mediated HO-1 signaling cascade. | Alam, Md Badrul; Chowdhury, Nargis Sultana; Sohrab, Md Hossain; Rana, Md Sohel; Hasan, Choudhury Mahmood; Lee, Sang-Han | Kyungpook Natl Univ, Grad Sch, Dept Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Inner Beauty Antiaging Ctr, Food & Bioind Res Inst, Daegu 41566, South Korea; Manarat Int Univ, Dept Pharm, Dhaka 1212, Bangladesh; BCSIR Labs, PSRD, Dhaka 1205, Bangladesh; Jahangirnagar Univ, Dept Pharm, Dhaka 1342, Bangladesh; Univ Dhaka, Dept Pharmaceut Chem, Dhaka 1205, Bangladesh; Knu BnC, Daegu 41566, Bangladesh | Lee, Seung Eun/ABG-1607-2021; Alam, Md Badrul/AAK-7176-2021 | 56706777100; 38662263600; 6602262411; 59678934400; 7005576989; 57221453703 | mbalam@knu.ac.kr;nscmiu@gmail.com;mhsohrab@bcsir.gov.bd;sohelrana.ju@gmail.com;cmhasan@gamil.com;sang@knu.ac.kr; | BIOMOLECULES | BIOMOLECULES | 2218-273X | 10 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2020 | 4.879 | 32.4 | 2.46 | 2025-06-25 | 60 | 60 | cerevisterol; Fusarium solani; Aponogeton undulatus Roxb; NF-kappa B; Nrf2; HO-1 | NF-KAPPA-B; STIMULATED RAW 264.7; HEME OXYGENASE-1; ANTIINFLAMMATORY ACTIVITY; MAPK; AP-1; MACROPHAGES; PATHWAYS; EXPRESSION; EXERTS | Aponogeton undulatus Roxb; Cerevisterol; Fusarium solani; HO-1; NF-κB; Nrf2 | Animals; Anti-Inflammatory Agents; Cell Survival; Dinoprostone; Fusarium; Heme Oxygenase-1; Inflammation; Magnoliopsida; MAP Kinase Signaling System; Membrane Proteins; Mice; Molecular Docking Simulation; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide; Phosphorylation; Phytosterols; RAW 264.7 Cells; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Transcription Factor AP-1; antiinflammatory agent; cerevisterol; heme oxygenase 1; immunoglobulin enhancer binding protein; interleukin 1beta; interleukin 6; nitric oxide; prostaglandin E2; reactive oxygen metabolite; small interfering RNA; sterol; transcription factor AP 1; transcription factor Nrf2; unclassified drug; antiinflammatory agent; cerevisterol; heme oxygenase 1; Hmox1 protein, mouse; immunoglobulin enhancer binding protein; membrane protein; Nfe2l2 protein, mouse; phytosterol; prostaglandin E2; transcription factor AP 1; transcription factor Nrf2; Article; cell culture; cell viability; controlled study; down regulation; enzyme linked immunosorbent assay; fungal strain; Fusarium solani; gene expression; genetic transfection; human; human cell; immunoblotting; inflammation; luciferase assay; macrophage; MAPK signaling; molecular docking; MTT assay; protein expression; protein phosphorylation; RAW 264.7 cell line; reverse transcription polymerase chain reaction; signal transduction; Western blotting; angiosperm; animal; cell survival; chemistry; Fusarium; inflammation; MAPK signaling; metabolism; microbiology; mouse; phosphorylation; signal transduction | English | 2020 | 2020-02 | 10.3390/biom10020199 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Development of 6′-N-Acylated Isepamicin Analogs with Improved Antibacterial Activity against Isepamicin-Resistant Pathogens | The development of new aminoglycoside (AG) antibiotics has been required to overcome the resistance mechanism of AG-modifying enzymes (AMEs) of AG-resistant pathogens. The AG acetyltransferase, AAC(6')-APH(2 ''), one of the most typical AMEs, exhibiting substrate promiscuity towards a variety of AGs and acyl-CoAs, was employed to enzymatically synthesize new 6'-N-acylated isepamicin (ISP) analogs, 6'-N-acetyl/-propionyl/-malonyl ISPs. They were all active against the ISP-resistant Gram-negative bacteria tested, and the 6'-N-acetyl ISP displayed reduced toxicity compared to ISP in vitro. This study demonstrated the importance of the modification of the 6'-amino group in circumventing AG-resistance and the potential of regioselective enzymatic modification of AG scaffolds for the development of more robust AG antibiotics. | Ban, Yeon Hee; Song, Myoung Chong; Kim, Hee Jin; Lee, Heejeong; Wi, Jae Bok; Park, Je Won; Lee, Dong Gun; Yoon, Yeo Joon | Seoul Natl Univ, Coll Pharm, Nat Prod Res Inst, Seoul 08826, South Korea; Ewha Womans Univ, Dept Chem & Nanosci, Seoul 03760, South Korea; Kyungpook Natl Univ, Coll Nat Sci, BK21 Plus KNU Creat BioRes Grp, Sch Life Sci, Daehakro 80, Daegu 41566, South Korea; Korea Univ, Dept Integrated Biomed & Life Sci, Seoul 02841, South Korea | Lee, Dong-Gun/IWD-9833-2023; Song, Myoung/M-7381-2013; Song, Myoung Chong/M-7381-2013 | 35279095000; 9335354000; 56984405800; 56010549700; 57217173399; 8710254600; 55668060900; 7402126465 | yhban@snu.ac.kr;smch517@snu.ac.kr;kimijini93@gmail.com;gml09wjd@naver.com;slwlwhs@korea.ac.kr;jewonpark@korea.ac.kr;dglee222@knu.ac.kr;yeojoonyoon@snu.ac.kr; | BIOMOLECULES | BIOMOLECULES | 2218-273X | 10 | 6 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2020 | 4.879 | 32.4 | 0.27 | 2025-06-25 | 4 | 4 | isepamicin analogs; 6 '-N-acylation; enzymatic synthesis; antibacterial activity; cytotoxicity | AMINOGLYCOSIDE; ANTIBIOTICS; TOXICITY; SIDE | 6′-N-acylation; Antibacterial activity; Cytotoxicity; Enzymatic synthesis; Isepamicin analogs | Acylation; Anti-Bacterial Agents; Cells, Cultured; Drug Resistance, Bacterial; Escherichia coli; Gentamicins; Gram-Negative Bacteria; HEK293 Cells; Humans; Microbial Sensitivity Tests; Phosphotransferases (Alcohol Group Acceptor); Pseudomonas aeruginosa; Staphylococcus aureus; Toxicity Tests; 6′ n acylated isepamicin; aminoglycoside antibiotic agent; isepamicin; unclassified drug; aminoglycoside 2''-phosphotransferase; antiinfective agent; gentamicin; isepamicin; phosphotransferase; antibacterial activity; antibiotic sensitivity; antimicrobial activity; Article; binding affinity; carbon nuclear magnetic resonance; chemical structure; cytotoxicity assay; enzyme purification; enzyme synthesis; Escherichia coli; gene overexpression; IC50; in vitro study; infectious agent; infrared spectroscopy; liquid chromatography-mass spectrometry; MTT assay; nonhuman; proton nuclear magnetic resonance; ultra performance liquid chromatography; acylation; antibiotic resistance; cell culture; chemistry; drug effect; enzymology; genetics; Gram negative bacterium; growth, development and aging; HEK293 cell line; human; metabolism; microbial sensitivity test; Pseudomonas aeruginosa; Staphylococcus aureus; synthesis; toxicity testing | English | 2020 | 2020-06 | 10.3390/biom10060893 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Endogenous Collagenases Regulate Osteoclast Fusion | The precise regulation of osteoclast differentiation and function is crucial for the maintenance of healthy bone. Despite several reports of collagenase expression in bone tissues, the precise isoform expression as well as the role in osteoclasts are still unclear. In the present report, the expression of matrix metalloprotease (MMP)8 and MMP13 was confirmed in mouse bone marrow macrophage osteoclast precursors. The mRNA and protein expressions of both collagenases were significantly reduced by receptor activator of nuclear factor kappa B ligand (RANKL) stimulation. Notably, either inhibition of MMP expression by siRNA or treatment of cells with collagenase inhibitor Ro 32-3555 significantly augmented osteoclast fusion and resorption activity without affecting the osteoclast number. The inhibition of collagenase by Ro 32-3555 increased the expression of osteoclast fusion genes, Atp6v0d2 and Dcstamp, without affecting nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) protein expression. The enhanced osteoclast fusion by collagenase inhibition appears to be mediated through an extracellular signal regulated kinase (ERK)-dependent pathway. Collectively, these data provide novel information on the regulation of osteoclast fusion process. | Kim, Hyo Jeong; Lee, Youngkyun | Kyungpook Natl Univ, Sch Dent, Dept Biochem, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Inst Hard Tissue & Biotooth Regenerat IHBR, Daegu 41940, South Korea | 57203629899; 36062942200 | hjsm48@nate.com;ylee@knu.ac.kr; | BIOMOLECULES | BIOMOLECULES | 2218-273X | 10 | 5 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2020 | 4.879 | 32.4 | 0.27 | 2025-06-25 | 7 | 7 | collagenase; osteoclast; fusion; ERK | MATRIX-METALLOPROTEINASE; GENE-EXPRESSION; DC-STAMP; KAPPA-B; BONE; DIFFERENTIATION; ACTIVATION; MMP-13; OSTEOBLASTS; INHIBITION | Collagenase; ERK; Fusion; Osteoclast | Animals; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Female; Humans; Imidazoles; MAP Kinase Signaling System; Matrix Metalloproteinase 13; Matrix Metalloproteinase 8; Matrix Metalloproteinase Inhibitors; Membrane Proteins; Mice; Mice, Inbred ICR; NFATC Transcription Factors; Osteoclasts; RANK Ligand; Vacuolar Proton-Translocating ATPases; acid phosphatase tartrate resistant isoenzyme; beta actin; caffeic acid; calcitonin receptor; cathepsin K; colecalciferol; collagenase; colony stimulating factor 1; cyclosporine; lipopolysaccharide; matrix metalloprotease 13; matrix metalloprotease 8; messenger RNA; metalloproteinase; mitogen activated protein kinase; mitogen activated protein kinase 1; mitogen activated protein kinase 3; osteoclast differentiation factor; prostaglandin E2; RhoA guanine nucleotide binding protein; small interfering RNA; unclassified drug; Atp6v0d2 protein, mouse; cipemastat; collagenase 3; Dcstamp protein, mouse; imidazole derivative; matrix metalloproteinase inhibitor; membrane protein; Mmp13 protein, mouse; MMP8 protein, mouse; neutrophil collagenase; Nfatc1 protein, mouse; osteoclast differentiation factor; proton transporting adenosine triphosphate synthase; transcription factor NFAT; animal cell; animal tissue; Article; bone metabolism; bone tissue; calvaria; cell migration; cell size; controlled study; female; finite element analysis; gene expression; gene knockdown; genetic transfection; human; macrophage; morphometry; mouse; nonhuman; osteoclast; osteoclastogenesis; protein expression; real time polymerase chain reaction; reverse transcription polymerase chain reaction; signal transduction; Western blotting; animal; bone marrow cell; cell culture; cell differentiation; cytology; drug effect; genetics; Institute for Cancer Research mouse; MAPK signaling; metabolism; osteoclast | English | 2020 | 2020-05 | 10.3390/biom10050705 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Hemistepsin A Inhibits Cell Proliferation and Induces G0/G1-Phase Arrest, Cellular Senescence and Apoptosis Via the AMPK and p53/p21 Signals in Human Hepatocellular Carcinoma | Hemistepsin A (HsA), a natural sesquiterpene lactone isolated from Hemistepta lyrata, has been known as a wide range of anti-tumor effects. The aim of this study was to determine whether HsA suppresses hepatocellular carcinoma (HCC) and to figure out the cellular signaling pathways involved in the anti-HCC activities by experiments using the Huh7 cells (a human HCC cell line) and a xenograft HCC model. In this study, HsA completely inhibited HCC cell proliferation, presumably because it induced G0/G1 cell cycle arrest and mitochondrial-related apoptosis. HsA up-regulated p53, p21, cleaved caspase-3 and cleaved PARP (poly (ADP-ribose) polymerase), but reduced cyclin D, CDK6 and Bcl-2 expressions, and it disrupted mitochondrial membrane potential (Delta Psi m). Moreover, phosphorylation of AMP-activated protein kinase (AMPK) was increased by HsA as did the resveratrol and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR, positive controls). Inhibition of AMPK by using compound C, a competent inhibitor of AMPK, attenuated the loss of Delta Psi m, p53 up-regulation and cellular senescence. The efficacy of HsA to reduce HCC cell proliferation, compared to that of other known anti-HCC agents, appears to be similar or slightly better. The anti-tumor effect of HsA was also determined in mice, showing reduced growth of xenografted tumors with no weight loss. Overall, the results suggest that HsA should be considered as a candidate anti-HCC drug. | Baek, Su Youn; Hwang, Ui Wook; Suk, Ho Young; Kim, Young Woo | Kyungpook Natl Univ, Inst Phylogen & Evolut, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Korean Herb Bio Convergence Promot, Daegu 41566, South Korea; Kyungpook Natl Univ, Teachers Coll, Dept Biol Educ, Daegu 41566, South Korea; Yeungnam Univ, Dept Life Sci, 280 Daehak Ro, Gyongsan 38541, Gyeongsangbuk D, South Korea; Dongguk Univ, Sch Korean Med, Gyeongju 38066, South Korea | 57192371420; 35074015800; 7005704783; 55699527800 | rhodeus@nate.com;uwhwang1@gmail.com;hsuk@yu.ac.kr;ywk@dongguk.ac.kr; | BIOMOLECULES | BIOMOLECULES | 2218-273X | 10 | 5 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2020 | 4.879 | 32.4 | 1 | 2025-06-25 | 25 | 26 | hemistepsin A (HsA); hepatocellular carcinoma (HCC); AMP-activated protein kinase (AMPK/mTOR); p53; G0/G1 cell cycle arrest; apoptosis | SESQUITERPENE LACTONE; ACTIVATION; P53; CANCER; DEATH | AMP-activated protein kinase (AMPK/mTOR); Apoptosis; G0/G1 cell cycle arrest; Hemistepsin A (HsA); Hepatocellular carcinoma (HCC); P53 | Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; G1 Phase Cell Cycle Checkpoints; Hep G2 Cells; Humans; Lactones; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Protein Kinases; Sesquiterpenes; Signal Transduction; Tumor Suppressor Protein p53; 5 amino 4 imidazolecarboxamide riboside; antineoplastic agent; beta galactosidase; chenodeoxycholic acid; cyclin D; cyclin D1; cyclin dependent kinase 6; cyclin E; deoxypodophyllotoxin; doxorubicin; hemistepsin a; hydroxymethylglutaryl coenzyme A reductase kinase; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; protein bcl 2; protein p21; protein p53; resveratrol; sesquiterpene lactone derivative; sorafenib; unclassified drug; AMP-activated protein kinase kinase; antineoplastic agent; cyclin dependent kinase inhibitor 1A; hemistepsin; lactone; protein kinase; protein p53; sesquiterpene; AMPK signaling; animal experiment; animal model; apoptosis; Article; cell aging; cell death; cell migration; cell proliferation; cell viability; controlled study; down regulation; drug dose comparison; drug efficacy; flow cytometry; G1 phase cell cycle checkpoint; Huh-7 cell line; human; human cell; incubation time; liver cell carcinoma; mitochondrial membrane potential; mouse; MTT assay; nonhuman; p53/p21 signaling; percentage of cells in G0/G1 phase; percentage of cells in G2/M phase; phase contrast microscopy; protein expression level; protein phosphorylation; signal transduction; tumor growth; tumor volume; upregulation; Western blotting; wound healing assay; animal; apoptosis; Bagg albino mouse; cell proliferation; drug effect; G1 phase cell cycle checkpoint; Hep-G2 cell line; liver cell carcinoma; liver tumor; metabolism; nude mouse; signal transduction | English | 2020 | 2020-05 | 10.3390/biom10050713 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Network Pharmacology-Based Approaches of Rheum undulatum Linne and Glycyrriza uralensis Fischer Imply Their Regulation of Liver Failure with Hepatic Encephalopathy in Mice | Rheum undulatum and Glycyrrhiza uralensis have been used as supplementary ingredients in various herbal medicines. They have been reported to have anti-inflammatory and antioxidant effects and, therefore, have potential in the treatment and prevention of various liver diseases. Considering that hepatic encephalopathy (HE) is often associated with chronic liver failure, we investigated whether an R. undulatum and G. uralensis extract mixture (RG) could reduce HE. We applied systems-based pharmacological tools to identify the active ingredients in RG and the pharmacological targets of RG by examining mechanism-of-action profiles. A CCl4-induced HE mouse model was used to investigate the therapeutic mechanisms of RG on HE. We successfully identified seven bioactive ingredients in RG with 40 potential targets. Based on an integrated target-disease network, RG was predicted to be effective in treating neurological diseases. In animal models, RG consistently relieved HE symptoms by protecting blood-brain barrier permeability via downregulation of matrix metalloproteinase-9 (MMP-9) and upregulation of claudin-5. In addition, RG inhibited mRNA expression levels of both interleukin (IL)-1 beta and transforming growth factor (TGF)-beta 1. Based on our results, RG is expected to function various biochemical processes involving neuroinflammation, suggesting that RG may be considered a therapeutic agent for treating not only chronic liver disease but also HE. | Baek, Su Youn; Lee, Eun Hye; Oh, Tae Woo; Do, Hyun Ju; Kim, Kwang-Youn; Park, Kwang-Il; Kim, Young Woo | Kyungpook Natl Univ, Inst Phylogen & Evolut, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med Sci, Daegu 41566, South Korea; Korea Inst Oriental Med, Daegu 41566, South Korea; Gyeongsang Natl Univ, Coll Vet Med, Jinju 52828, South Korea; Dongguk Univ, Sch Korean Med, Gyeongju 38066, South Korea | ; Lee, Eun-Hye/KDN-5679-2024 | 57192371420; 57189661699; 37047501300; 46461128400; 58076309300; 55722171100; 55699527800 | rhodeus@nate.com;eun90hye@nate.com;taewoo2080@kiom.re.kr;dododo@kiom.re.kr;lokyve@kiom.re.kr;kipark@gnu.ac.kr;ywk@dongguk.ac.kr; | BIOMOLECULES | BIOMOLECULES | 2218-273X | 10 | 3 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2020 | 4.879 | 32.4 | 0.4 | 2025-06-25 | 8 | 10 | Rheum undulatum; Glycyrriza uralensis; hepatic encephalopathy; MMP-9; neuroinflammation | BLOOD-BRAIN-BARRIER; DISRUPTION; RHUBARB; TRANSPLANTATION; ANTHRAQUINONES; CLAUDIN-5; CELLS; RHEIN | Glycyrriza uralensis; Hepatic encephalopathy; MMP-9; Neuroinflammation; Rheum undulatum | Animals; Disease Models, Animal; Fabaceae; Hepatic Encephalopathy; Liver Failure; Male; Mice; Mice, Inbred BALB C; Plant Extracts; Rheum; carbon tetrachloride; chrysophanic acid; claudin 5; emodin; gelatinase B; Glycyrrhiza uralensis extract; glycyrrhizic acid; interleukin 1beta; isoliquiritigenin; liquiritigenin; messenger RNA; plant extract; rhein; Rheum undulatum extract; sennoside A; transforming growth factor beta1; unclassified drug; water; plant extract; analysis; animal cell; animal experiment; animal model; animal tissue; Article; blood brain barrier; controlled study; down regulation; drug analysis; drug mechanism; drug targeting; gene expression; Glycyrrhiza uralensis; hepatic encephalopathy; integrated target disease network; liver failure; male; membrane permeability; mouse; mouse model; nervous system inflammation; network pharmacology; neurologic disease; nonhuman; pharmacology; prediction; Rheum; Rheum undulatum; upregulation; animal; Bagg albino mouse; chemistry; complication; disease model; Fabaceae; hepatic encephalopathy; liver failure; metabolism; pathology | English | 2020 | 2020-03 | 10.3390/biom10030437 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Phytogenic Generation of NiO Nanoparticles Using Stevia Leaf Extract and Evaluation of Their In-Vitro Antioxidant and Antimicrobial Properties | In the present study, economically viable NiO nanoparticles were produced by biogenic preparation using stevia leaf broth and their in-vitro antioxidant and antimicrobial activities were evaluated. The properties of the prepared NiO nanoparticles were confirmed by analytical techniques such as Ultraviolet-Visible (UV-Vis), X-ray diffraction (XRD), FE-SEM, and Fourier transform infrared spectroscopy (FTIR) analyses. Morphological studies using scanning electron microscopy (SEM) and transmission electron microscopy (TEM) showed that the size of synthesized nanoparticles ranged from 20 to 50 nm, most of which were spherical and few of which were agglomerated. The role of the biological moieties, which reduce and cap the nanoparticles, was studied using FTIR analysis. The prepared nanoparticles strongly inhibited gram-negative bacteria, which is a camper with gram-positive bacteria and fungi. Furthermore, it performs an effective in-vitro activity through alpha,alpha-diphenyl-beta-picrylhydrazyl (DPPH) reduction. Thus, it can be concluded that the effective and easy green synthesis process used for NiO nanoparticles provides potential antimicrobial agents against multidrug-resistant microbes. | Srihasam, Saiganesh; Thyagarajan, Krishnan; Korivi, Mallikarjuna; Lebaka, Veeranjaneya Reddy; Mallem, Siva Pratap Reddy | Jawaharlal Nehru Technol Univ, Dept Phys, Anantapur 515002, Anantapuramu, India; Jawaharlal Nehru Technol Univ, Dept Phys, Pulivendula 516390, India; Zhejiang Normal Univ, Coll Phys Educ & Hlth Sci, Exercise & Metab Res Ctr, Jinhua 321004, Zhejiang, Peoples R China; Yeungnam Univ, Dept Food Sci & Technol, Gyeongbuk 38541, South Korea; Yogi Vemana Univ, Dept Microbiol, Kadapa 516003, Andhra Pradesh, India; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea | Lebaka, Reddy/E-7347-2016; Korivi, Mallikarjuna/C-7952-2012; Thyagarajan, Krishnan/AAZ-8088-2021 | 57213605143; 57213214401; 6505851696; 9037435100; 55422639100 | srihasamsaiganesh@gmail.com;ktrjntu@gmail.com;mallik.k5@gmail.com;lvereddy@yahoo.com;dr.mspreddy@gmail.com; | BIOMOLECULES | BIOMOLECULES | 2218-273X | 10 | 1 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2020 | 4.879 | 32.4 | 5.12 | 2025-06-25 | 101 | 116 | stevia broth; biogenic preparation; NiO nanoparticles; antibacterial; anti-oxidant activity | GREEN SYNTHESIS; NICKEL-OXIDE; ANTIBACTERIAL ACTIVITY; LEAVES; FABRICATION; OXIDATION | Anti-oxidant activity; Antibacterial; Biogenic preparation; NiO nanoparticles; Stevia broth | Anti-Bacterial Agents; Anti-Infective Agents; Antioxidants; Gram-Negative Bacteria; Gram-Positive Bacteria; Green Chemistry Technology; Metal Nanoparticles; Microbial Sensitivity Tests; Microscopy, Electron, Transmission; Nickel; Particle Size; Plant Extracts; Plant Leaves; Spectroscopy, Fourier Transform Infrared; Stevia; X-Ray Diffraction; antiinfective agent; antioxidant; chloramphenicol; nanoparticle; nickel oxide nanoparticle; plant extract; Stevia extract; unclassified drug; antiinfective agent; antioxidant; metal nanoparticle; nickel; nickel monoxide; plant extract; antimicrobial activity; antioxidant activity; Article; Aspergillus fumigatus; Aspergillus niger; Bacillus subtilis; clinical effectiveness; controlled study; DPPH radical scavenging assay; drug effect; drug efficacy; drug mechanism; drug response; Escherichia coli; field emission scanning electron microscopy; Fourier transform infrared spectroscopy; in vitro study; nonhuman; particle size; plant leaf; scanning electron microscopy; Stevia; Streptococcus pneumonia; transmission electron microscopy; ultraviolet visible spectroscopy; X ray diffraction; zone of inhibition; chemistry; Gram negative bacterium; Gram positive bacterium; green chemistry; infrared spectroscopy; metabolism; microbial sensitivity test; plant leaf; procedures | English | 2020 | 2020-01 | 10.3390/biom10010089 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | The Role of Natural Compounds and their Nanocarriers in the Treatment of CNS Inflammation | Neuroinflammation, which is involved in various inflammatory cascades in nervous tissues, can result in persistent and chronic apoptotic neuronal cell death and programmed cell death, triggering various degenerative disorders of the central nervous system (CNS). The neuroprotective effects of natural compounds against neuroinflammation are mainly mediated by their antioxidant, anti-inflammatory, and antiapoptotic properties that specifically promote or inhibit various molecular signal transduction pathways. However, natural compounds have several limitations, such as their pharmacokinetic properties and stability, which hinder their clinical development and use as medicines. This review discusses the molecular mechanisms of neuroinflammation and degenerative diseases of CNS. In addition, it emphasizes potential natural compounds and their promising nanocarriers for overcoming their limitations in the treatment of neuroinflammation. Moreover, recent promising CNS inflammation-targeted nanocarrier systems implementing lesion site-specific active targeting strategies for CNS inflammation are also discussed. | Khadka, Bikram; Lee, Jae-Young; Park, Dong Ho; Kim, Ki-Taek; Bae, Jong-Sup | Mokpo Natl Univ, Dept Biomed Hlth & Life Convergence Sci, BK21-4, Jeonnam 58554, South Korea; Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Ophthalmol, Daegu 41944, South Korea; Mokpo Natl Univ, Coll Pharm, Jeonnam 58554, South Korea; Mokpo Natl Univ, Nat Med Res Inst, Jeonnam 58554, South Korea; Kyungpook Natl Univ, Pharmaceut Sci Res Inst, Coll Pharm, CMR1, Daegu 41566, South Korea | ; Bae, Jong-Sup/AAU-9724-2020; Lee, Jae-Yeong/AEP-9607-2022 | 57219279407; 56195895300; 36676632900; 24488281700; 16021543200 | khadkabikram180@gmail.com;jaeyoung@cnu.ac.kr;DongHo_Park@knu.ac.kr;ktkim0628@mokpo.ac.kr;baejs@knu.ac.kr; | BIOMOLECULES | BIOMOLECULES | 2218-273X | 10 | 10 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2020 | 4.879 | 32.4 | 0.28 | 2025-06-25 | 16 | 19 | neuroinflammation; central nervous system (CNS) degenerative diseases; natural compounds; neuroprotective; nanocarriers; blood-brain barrier (BBB); targeting | SOLID LIPID NANOPARTICLES; BLOOD-BRAIN-BARRIER; S-ALLYL CYSTEINE; DRUG-DELIVERY; IN-VITRO; CEREBRAL-ISCHEMIA; CARBON NANOTUBES; OXIDATIVE DAMAGE; TANSHINONE IIA; AMYLOID-BETA | Blood–brain barrier (BBB); Central nervous system (CNS) degenerative diseases; Nanocarriers; Natural compounds; Neuroinflammation; Neuroprotective; Targeting | Apoptosis; Blood-Brain Barrier; Central Nervous System; Drug Delivery Systems; Humans; Inflammation; Nanoparticles; Neurons; Neuroprotective Agents; alkaloid; alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid; alpha synuclein; anthocyanin; apolipoprotein E; beta secretase 1; brain derived neurotrophic factor; colecalciferol; copper zinc superoxide dismutase; cryopyrin; curcumin; cyclooxygenase 2; Fas associated death domain protein; gallic acid; genistein; ginsenoside; glutathione peroxidase; huntingtin; hydroxymethylglutaryl coenzyme A reductase kinase; immunoglobulin enhancer binding protein; interleukin 10; interleukin 1beta; interleukin 4; interleukin 6; interleukin 8; lycopene; monocyte chemotactic protein 1; n methyl dextro aspartic acid receptor; nanocarrier; nitrogen oxide; omega 3 fatty acid; phenol derivative; piperine; quercetin; reactive oxygen metabolite; resveratrol; s allylcysteine; tanshinone; terpenoid derivative; toll like receptor 4; transforming growth factor beta; tumor necrosis factor receptor; tumor necrosis factor receptor superfamily member 6; ubidecarenone; nanoparticle; neuroprotective agent; Alzheimer disease; amyotrophic lateral sclerosis; antiinflammatory activity; astrocyte; blood brain barrier; cell infiltration; central nervous system; cytokine production; degenerative disease; disease duration; disease severity; disorders of mitochondrial functions; human; Huntington chorea; innate immunity; JAK-STAT signaling; lipid oxidation; macrophage; MAPK signaling; microglia; multiple sclerosis; nanomedicine; necroptosis; nervous system inflammation; neuroapoptosis; nonhuman; oxidative stress; Parkinson disease; phase 2 clinical trial (topic); phytochemistry; protein expression; protein phosphorylation; pyroptosis; Review; traumatic brain injury; apoptosis; chemistry; diagnostic imaging; drug delivery system; drug effect; inflammation; metabolism; nerve cell; pathology | English | 2020 | 2020-10 | 10.3390/biom10101401 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A novel method of vesicle preparation by simple dilution of bicelle solution | We prepared phospholipid vesicles in continuous dilution from small phospholipid bilayer bicelles. As vesicles are useful as delivery carriers, it is necessary to develop a method of continuous encapsulation. Bicelles are composed of long-chain 1,2-dimyristoyl-sn-glycero-3-phosphocholine in bilayers and short-chain 1,2-dihexanoyl-sn-glycero-3-phosphocholine as a detergent. Bicelles were diluted in a batch system and a flow system and their membrane properties were compared; sizes were analyzed by dynamic light scattering and membrane properties by fluorescence spectroscopy. In the flow system, the initial bicelles (10 - 20 nm) coalesced by dilution and hydration of the detergent into large vesicles ( > 30 nm). Uptake of methylene blue solution revealed the internal aqueous phase. Transmission electron microscopy confirmed the formation of vesicles by dilution. The membrane fluidity of the vesicles showed an ordered gel phase. The results suggest that bicelles can form vesicles by continuous dilution. This method is suitable for encapsulating materials. | Taguchi, Shogo; Kang, Bong-Su; Suga, Keishi; Okamoto, Yukihiro; Jung, Ho-Sup; Umakoshi, Hiroshi | Univ Hyogo, Grad Sch Engn, Dept Chem Engn & Mat Sci, 2167 Shosha, Himeji, Hyogo 6712280, Japan; Kyungpook Natl Univ, Sch Mech Engn, 80 Daehak Ro, Daegu 41566, South Korea; Tohoku Univ, Grad Sch Engn, Dept Chem Engn, Aoba Ku, 6-6-07 Aoba Aramaki Asa, Sendai, Miyagi 9808579, Japan; Osaka Univ, Grad Sch Engn Sci, Div Chem Engn, 1-3 Machikaneyama Cho, Toyonaka, Osaka 5608531, Japan; Seoul Natl Univ, Ctr Food & Bioconvergence, Dept Food Sci & Biotechnol, 1 Gwanak Ro, Seoul 08826, South Korea | Jung, Hosup/AAB-5708-2020; UMAKOSHI, HIROSHI/O-4583-2016; Okamoto, Yukihiro/N-4128-2018 | 57059904200; 55330925300; 58074932700; 35269706600; 36985354800; 6701925853 | taguchis@eng.u-hyogo.ac.jp;bong-su@knu.ac.kr;keishi.suga.b7@tohoku.ac.jp;okamoto@cheng.es.osaka-u.ac.jp;jhs@snu.ac.kr;umakoshi@cheng.es.osaka-u.ac.jp; | BIOCHEMICAL ENGINEERING JOURNAL | BIOCHEM ENG J | 1369-703X | 1873-295X | 162 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;ENGINEERING, CHEMICAL | 2020 | 3.978 | 32.5 | 0.45 | 2025-06-25 | 9 | 9 | Bicelle; Continuous vesicle preparation; Dilution process | LIPOSOMES; NMR; TRANSITION; PROTEINS | Bicelle; Continuous vesicle preparation; Dilution process | Aromatic compounds; Fluorescence spectroscopy; High resolution transmission electron microscopy; Light scattering; Liposomes; Phospholipids; fluorescent dye; laurdan; methylene blue; reactive oxygen metabolite; Aqueous phase; Batch systems; Delivery carriers; Membrane fluidity; Membrane properties; Methylene blue solution; Phospholipid bilayer; Phospholipid vesicles; absorption; apoptosis; aqueous solution; Article; cell membrane fluidity; critical micelle concentration; dilution; fluidization; hydration; hydrophobicity; measurement; melting temperature; membrane fluidity; phospholipid bilayer; phospholipid vesicle; photon correlation spectroscopy; physical chemistry; polarization; priority journal; room temperature; spectrofluorometry; transmission electron microscopy; Dilution | English | 2020 | 2020-10-15 | 10.1016/j.bej.2020.107725 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Aggregate Properties Affecting Shear Strength and Permanent Deformation Characteristics of Unbound-Base Course Materials | Resistance to permanent deformation is the primary performance indicator of unbound aggregate pavement layers. In relation to the applied wheel-load deviator stress, the shear strength property of a confined base/subbase controls the rate of permanent strain accumulation in that aggregate layer. The objective of this study was to quantify the impact of aggregate properties on the shear strength and permanent deformation characteristics of unbound aggregates. Sixteen different aggregates were studied in the laboratory for two different gradations: original quarry source and engineered midrange gradations. Aggregate specimens were prepared at these gradations to determine moisture-density relationships, and conduct monotonic and repeated load triaxial tests at the target maximum dry densities and optimal moisture contents. In addition, imaging-based aggregate particle shapes or morphological indices were obtained. The laboratory findings indicated that the particle size corresponded to 60% passing, and imaging-based angularity index contributed significantly to the increases in the shear strength properties of aggregates, which were also affected by density and moisture content. Permanent strain accumulations were primarily influenced by applied shear stress in relation to the shear strength of aggregates, and rutting model parameters obtained through regression analyses were influenced by applied stress, strength, and material properties. Further, an aggregate with plastic fines showed the highest permanent strain accumulation, hence clearly indicating the significant influence of plasticity of fines on the permanent strain accumulation. | Byun, Yong-Hoon; Feng, Bin; Qamhia, Issam I. A.; Tutumluer, Erol | Kyungpook Natl Univ, Sch Agr Civil & Bioind Engn, 80 Daehak Ro, Daegu 41566, South Korea; Univ Illinois, Dept Civil & Environm Engn, 205 North Mathews Ave, Urbana, IL 61801 USA | Tutumluer, Erol/O-2650-2019; Byun, Yong-Hoon/JKI-8441-2023 | yhbyun@knu.ac.kr; | JOURNAL OF MATERIALS IN CIVIL ENGINEERING | J MATER CIVIL ENG | 0899-1561 | 1943-5533 | 32 | 1 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2020 | 3.266 | 32.5 | 22 | Unbound aggregates; Base; subbase; Gradation; Shear strength; Permanent deformation | SHAPE | English | 2020 | 2020-01-01 | 10.1061/(asce)mt.1943-5533.0003000 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | Article | Chemically Induced Calcium Carbonate Precipitation for Improving Strength of Sand | Chemically induced calcium carbonate precipitation (CCP) using calcium hydroxide (CH) and carbon dioxide (CO2) was employed to clean sand for improving its strength. Joomunjin sand was mixed with 2% CH and 10% water, and then cured in a CO2 chamber under 100 or 200 kPa for 2 h. The treatments were repeated 1, 5, and 10 times. At the last treatment cycle, the treated sand was compacted into a mold for testing. A series of unconfined compression and direct shear tests were conducted on the treated sand to evaluate the effects of the CCP on the strength of the clean sand. Scanning electron microscopy (SEM) and X-ray powder diffraction (XRD) analysis were performed to evaluate the CCP and microstructure of the treated sand. The experimental results indicated that the effect of change in the CO2 chamber pressure on the calcium carbonate content (CCC) was insignificant due to the low pressures applied. As the number of treatments increased from 1 to 10, the CCC increased from 2% to 23%, resulting in increases of the unconfined compressive strength (UCS), and friction angle of treated sand. The efficiency of converting CH to CaCO3 reached 87% after 10 cycles. The UCS increased from 51 to 364 kPa as the number of treatments increased from 1 to 10. The friction angle and cohesion of clean sand also increased from 32 degrees and 0 kPa to 49 degrees and 53 kPa, respectively. (c) 2020 American Society of Civil Engineers. | Park, Sung-Sik; Le, Trung-Tri; Nong, Zhenzhen; Moon, Hong-Duk; Lee, Dong-Eun | Kyungpook Natl Univ, Dept Civil Engn, Daegu 41566, South Korea; Gyeongnam Natl Univ Sci & Technol, Dept Civil Engn, Jinju 52725, South Korea; Kyungpook Natl Univ, Dept Architectural Engn, Daegu 41566, South Korea | ; Le, Tri/ABA-9597-2021 | sungpark@knu.ac.kr;ltrungtri@gmail.com;juses0125@gmail.com;hdmoon@gntech.ac.kr;dolee@knu.ac.kr; | JOURNAL OF MATERIALS IN CIVIL ENGINEERING | J MATER CIVIL ENG | 0899-1561 | 1943-5533 | 32 | 9 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2020 | 3.266 | 32.5 | 19 | Calcium hydroxide; Carbon dioxide; Calcite binder; Sand; Strength | UNCONFINED COMPRESSIVE STRENGTH; REINFORCEMENT; CAPTURE; SURFACE | English | 2020 | 2020-09-01 | 10.1061/(asce)mt.1943-5533.0003318 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | Correction | Effects of Sustained Loading and Temperature on a Concrete-Epoxy Bonded Interface (March, 2020) | Jeong, Yoseok; Lopez, Maria M.; Bakis, Charles E. | Kyungpook Natl Univ, Dept Construct & Disaster Prevent Engn, Gyeongbuk 37224, South Korea; Modjeski & Masters Inc, Res, 100 Sterling Pkwy, Mechanicsburg, PA 17050 USA; Penn State Univ, Dept Engn Sci & Mech, 227 Hammond Bldg, University Pk, PA 16802 USA | Bakis, Charles/Q-8118-2017 | ysjeong@knu.ac.kr;MDLopez@modjeski.com;ceb5@psu.edu; | JOURNAL OF MATERIALS IN CIVIL ENGINEERING | J MATER CIVIL ENG | 0899-1561 | 1943-5533 | 32 | 10 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2020 | 3.266 | 32.5 | 0 | English | 2020 | 2020-10-01 | 10.1061/(asce)mt.1943-5533.0003393 | 바로가기 | 바로가기 | 바로가기 | ||||||||||||
| ○ | Article | Prediction of Service Life and Evaluation of Probabilistic Life-Cycle Cost for Surface-Repaired Carbonated Concrete | Concrete structures are economical and typically durable when exposed to a variety of environmental conditions. However, carbonation results in a reduction of the durability of reinforced concrete members because it damages the passive film surrounding the reinforcement, which accelerates corrosion processes and may ultimately lead to premature failure of the members. Predicting service life is complex because it depends strongly on changes in materials and environmental conditions. Existing carbonation models predict the service life based on deterministic theories. In this study, deterministic and probabilistic methods are applied to study concrete carbonation in the presence of repair materials using the maintenance periods and repair cost according to the coefficient of variation (COV) of the carbonation depth of each repair material. Water-based paint, organic alkaline inhibitor, inhibiting surface coating, and corrosion-inhibiting mortar (IM) were used as repair materials. An accelerated carbonation experiment using 20% CO2 was performed for 5 days, and then the repair materials were applied on the concrete surface. Then the samples were put back in the carbonation chamber and carbonation depth was measured after 7, 14, and 28 days. Based on the COV value, the carbonation depth and maintenance periods were predicted. These were used as parameters for the probabilistic life-cycle cost (LCC) model. Results showed that carbonation inhibition was best when the repair was done using IM. Cost results obtained from deterministic and probabilistic models were compared. When the probabilistic model is applied, the repair cost is evaluated as a curve, unlike with the deterministic model. The probabilistic model reduces the maximum cost by 50% compared to the deterministic model. As the COV decreased (indicating better quality concrete), the probabilistic model results approached those of the deterministic model evaluation. (c) 2020 American Society of Civil Engineers. | Lee, Hyungmin; Lee, Han-Seung; Suraneni, Prannoy; Singh, Jitendra Kumar; Mandal, Soumen | Univ Miami, Dept Civil Architectural & Environm Engn, 1251 Mem Dr, Coral Gables, FL 33146 USA; Hanyang Univ, Dept Architectural Engn, 1271 Sa 3 Dong, Ansan 15588, South Korea; Hanyang Univ, Innovat Durable Bldg & Infrastruct Res Ctr, Dept Architectural Engn, 1271 Sa 3 Dong, Ansan 15588, South Korea; Kyungpook Natl Univ, Intelligent Construct Automat Ctr, 80 Daehak Ro, Daegu 41566, South Korea | Singh, Jitendra/AAU-6579-2021; Lee, HanSeung/E-9087-2013; Lee, Han-Seung/E-9087-2013; Mandal, Soumen/AAB-3917-2021 | hxl791@miami.edu;ercleehs@hanyang.ac.kr;suranenip@miami.edu;jk200386@hanyang.ac.kr;sou.chm@gmail.com; | JOURNAL OF MATERIALS IN CIVIL ENGINEERING | J MATER CIVIL ENG | 0899-1561 | 1943-5533 | 32 | 10 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2020 | 3.266 | 32.5 | 6 | Probabilistic methods; Repair cost; Service life; Carbonation; Life cycle cost (LCC) | CORROSION; INFRASTRUCTURE; MAINTENANCE; ATTACK; CRACKS; DAMAGE; RISK | English | 2020 | 2020-10-01 | 10.1061/(asce)mt.1943-5533.0003390 | 바로가기 | 바로가기 | 바로가기 |
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