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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Compound-level identification of sasang constitution type-specific personalized herbal medicine using data science approach | Introduction: Sasang Constitutional Medicine (SCM) is a type of traditional Korean medicine where patients are classified as one of four Sasang constitution types (Sasang type) and medi-cations consisting of medicinal herbs are prescribed according to the Sasang type. Despite the importance of personalized medicine, the operation mechanism is largely unknown. To gain a better understanding, we investigated the compound information that composes Sasang type-specific personalized herbal medicines on both multivariate and univariate levels.Methods: Five machine learning classifiers including extremely randomized trees (ERT) were trained to investigate whether the Sasang type can be explained by compound information at the multivariate level. Hierarchical clustering was conducted to determine whether compounds are processed distributedly or specifically. Taxonomic and biosynthetic analyses were conducted on these compounds. A univariate level statistical test was conducted to provide more robust Sasang type-specific compound information.Results: Using the trained ERT classifier, sixty important compounds were extracted. The sixty compounds were clustered into three groups, corresponding to each Sasang type-prominent compounds, suggesting that most compounds have specific preference for the Sasang type. Structural and biosynthetic characteristics of these Sasang type-prominent compounds were determined based on taxonomy and pathway analyses. Fourteen compounds showed statistically significant relevance with the Sasang type. Additionally, we predicted the Sasang type of un-known herbs, which were confirmed by their biological effects in functional assays. Conclusion: This study investigated the personalized herbal medicines of the SCM using compound information. This study provided information on the chemical characteristics of the compounds that are essential for classifying the Sasang type of medicinal herbs, as well as predictions regarding the Sasang type of the commonly used but unidentified medicinal herbs. | Park, Sa-Yoon; Kim, Young Woo; Song, Yu Rim; Bak, Seon Been; Jang, Young Pyo; Kim, Il-Kon; Kim, Ji-Hwan; Kim, Chang-Eop | Gachon Univ, Coll Korean Med, Dept Physiol, Seongnam 13120, South Korea; Kyungpook Natl Univ, Dept Comp Sci & Engn, Daegu 41566, South Korea; Dongguk Univ, Sch Korean Med, Gyeongju 38066, South Korea; Kyung Hee Univ, Coll Pharm, Seoul 02447, South Korea; Gachon Univ, Gil Hosp Korean Med, Dept Sasang Constitut Med, Incheon 21565, South Korea | ; Jang, Young Pyo/AAJ-8782-2020; Park, Sa-Yoon/AFH-3513-2022 | 57197843146; 55699527800; 57437229000; 57455566300; 57193012972; 57919554300; 57203990182; 57194146036 | jani77@gachon.ac.kr;eopchang@gachon.ac.kr; | HELIYON | HELIYON | 2405-8440 | 9 | 2 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.4 | 20.5 | 0.47 | 2025-06-25 | 2 | 4 | Personalized herbal medicine; Sasang constitutional medicine; Chemical characteristics; Compound information | STRESS; YAP | Chemical characteristics; Compound information; Personalized herbal medicine; Sasang constitutional medicine | English | 2023 | 2023-02 | 10.1016/j.heliyon.2023.e13692 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Evaluation of physicochemical characteristics and centerline temperatures of Sr ceramic waste form | When disposing of spent fuel, nuclides such as Cs-137 and Sr-90, which generate short-term decay heat, must be removed from the spent nuclear fuel for efficient storage facility utilization. The Korea Atomic Energy Research Institute (KAERI) has been developing a nuclide management process that can enhance disposal efficiency by sorting and collecting primary nuclides and a technology for separating Sr nuclides from the spent nuclear fuels using precipitation and distillation. In this study, we prepared Sr ceramic waste form, SrTiO3, using the solid-state reaction method to immobilize the Sr nuclides, and its physicochemical properties were evaluated. Moreover, the radiological and thermal characteristics of the Sr waste form were evaluated by estimating the composition of Sr nuclides considering the spent nuclear fuel history such as burnup and cooling period. The waste form was found to be stable with good mechanical strength and leaching properties in addition to a low coefficient of thermal expansion, which would be advantageous for intermediate storage. Based on the experimental and radiological results, the centerline temperature of the waste form caused by Sr-90 nuclide was estimated using the steadystate conduction equation. The centerline temperature increased with increasing diameter of the waste form. When generating the SrTiO3 waste form using the Sr nuclide recovered after a cooling period of 10 years, the centerline temperature was estimated to exceed the melting point of SrTiO3 at a diameter of 0.275 m, under all burn-up conditions. These results provide fundamental data for the management and intermediate storage of Sr waste. | Lee, Byeonggwan; Choi, Jung-Hoon; Lee, Ki Rak; Kang, Hyun Woo; Eom, Hyeon Jin; Shin, Kyuchul; Park, Hwan-Seo | Korea Atom Energy Res Inst, 111 Daedeok Daero 989, Daejeon 34057, South Korea; Kyungpook Natl Univ, Dept Hydrogen & Renewable Energy, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Appl Chem, 80 Daehak Ro, Daegu 41566, South Korea | ; Lee, Byeonggwan/HPD-2363-2023 | 57201269846; 56227488100; 14420116600; 55128039500; 57222569272; 14030501800; 56175751900 | mrchoijh@kaeri.re.kr; | HELIYON | HELIYON | 2405-8440 | 9 | 7 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.4 | 20.5 | 0.35 | 2025-06-25 | 3 | 3 | Waste burden minimization technology; Nuclide management process; Sr waste form fabrication; High-level waste; Ceramic waste form; SrTiO3 | SYNROC-C; IMMOBILIZATION; SRTIO3 | Ceramic waste form; High-level waste; Nuclide management process; Sr waste form fabrication; SrTiO<sub>3</sub>; Waste burden minimization technology | English | 2023 | 2023-07 | 10.1016/j.heliyon.2023.e18406 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | In vitro and in vivo postprandial hypoglycemic effects and comprehensive metabolite profiling of Dangjo chili pepper (Capsicum annuum L. cv. Dangjo) | The Dangjo chili pepper (DJ) has been reported to contain various compounds with alpha-glucosidase inhibitory activity. However, the hypoglycemic effect of DJ and the active ingredients responsible have not been fully investigated. Herein, the current study aimed to examine DJ as a novel alpha-glucosidase inhibitor for the prevention of hyperglycemia. The identification of metabolites and the assessment of alpha-glucosidase inhibitory activity was conducted in three chili pepper species. Glucose uptake inhibition by DJ ethanol extract (DJE) was evaluated in Caco-2 cells. Furthermore, an oral carbohydrate tolerance test was performed in C57BL/6 mice. A total of 18 metabolites were identified in Dangjo, Green, and Cucumber chili peppers. Among these, quercitrin was one the most abundant flavonoid in DJ. The DJ showed the highest inhibition of alpha-glucosidase activity against both maltose and sucrose compared to other peppers. In addition, isoorientin, quercitrin, and DJE had similar inhibitory activities for both substrates. Glucose uptake was significantly inhibited in the DJE group compared to the control group. The mice were orally administered freeze-dried DJ at 150 and 300 mg/kg body weight (B.W.), and blood glucose levels were measured. Under glucose loading, both groups had significantly reduced blood glucose concentration compared to the control group (p = 0.001). Under maltose loading, the blood glucose concentration was decreased in the 150 mg/kg B.W. group compared to the control group (p = 0.025). These results indicate that Dangjo chili pepper has the potential to function as a postprandial hypoglycemic agent by inhibiting the alpha-glucosidase activity. | Kim, Kyeong Jin; Park, Soo-yeon; Kim, Jin Tae; Lee, Hong Jin; Jung, Sung Keun; Kim, Young-Jun; Lee, Choong Hwan; Byun, Sanguine; Kim, Ji Yeon | Seoul Natl Univ Sci & Technol, Dept Nano Bio Engn, 232 Gongneung Ro, Seoul 01811, South Korea; Seoul Natl Univ Sci & Technol, Dept Food Sci & Technol, 232 Gongneung Ro, Seoul 01811, South Korea; Chung Ang Univ, Dept Food Sci & Biotechnol, Anseong 17546, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Konkuk Univ, Dept Biosci & Biotechnol, Seoul 05029, South Korea; Yonsei Univ, Dept Biotechnol, Seoul 03722, South Korea | ; Park, Soo-yeon/HOH-1638-2023; Kim, Jin Man/HJO-8987-2023; Kim, Joo/X-7562-2019; Lee, Hong Jin/JYQ-2079-2024; Byun, Sanguine/AAR-5451-2021; Jung, SUNG KEUN/AGR-2623-2022 | 57204269550; 56498086600; 57200163432; 35766582000; 35310491400; 57211016047; 8934856300; 24490630000; 55873676800 | jiyeonk@seoultech.ac.kr; | FOOD BIOSCIENCE | FOOD BIOSCI | 2212-4292 | 2212-4306 | 51 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2023 | 4.8 | 20.5 | 0.94 | 2025-06-25 | 7 | 7 | Dangjo chili pepper; Quercitrin; Type 2 diabetes mellitus; Postprandial blood glucose; ?-Glucosidase inhibitor | ALPHA-GLUCOSIDASE; INHIBITION; AMYLASE | Dangjo chili pepper; Postprandial blood glucose; Quercitrin; Type 2 diabetes mellitus; α-Glucosidase inhibitor | English | 2023 | 2023-02 | 10.1016/j.fbio.2022.102180 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Increase of glutamate in satellite glial cells of the trigeminal ganglion in a rat model of craniofacial neuropathic pain | IntroductionSatellite glial cells (SGCs) that envelop the cell bodies of neurons in sensory ganglia have been shown to both release glutamate, and be activated by glutamate in the context of nociceptive signaling. However, little is known about the subpopulations of SGCs that are activated following nerve injury and whether glutamate mechanisms in the SGCs are involved in the pathologic pain.MethodsTo address this issue, we used light and electron microscopic immunohistochemistry to examine the change in the glutamate levels in the SGCs and the structural relationship between neighboring neurons in the trigeminal ganglion (TG) in a rat model of craniofacial neuropathic pain, CCI-ION.ResultsAdministration of ionomycin, ATP and Bz-ATP induced an increase of extracellular glutamate concentration in cultured trigeminal SGCs, indicating a release of glutamate from SGCs. The level of glutamate immunostaining in the SGCs that envelop neurons of all sizes in the TG was significantly higher in rats with CCI-ION than in control rats, suggesting that SGCs enveloping nociceptive as well as non-nociceptive mechanosensitive neurons are activated following nerve injury, and that the glutamate release from SGCs increases in pathologic pain state. Close appositions between substance-P (SP)-immunopositive (+) or calcitonin gene-related peptide (CGRP)+, likely nociceptive neurons, between Piezo1+, likely non-nociceptive, mechanosensitive neurons and SP+ or CGRP+ neurons, and between SGCs of neighboring neurons were frequently observed.DiscussionThese findings suggest that glutamate in the trigeminal SGCs that envelop all types of neurons may play a role in the mechanisms of neuropathic pain, possibly via paracrine signaling. | Cho, Yi Sul; Mah, Won; Youn, Dong Ho; Kim, Yu Shin; Ko, Hyoung-Gon; Bae, Jin Young; Kim, Yun Sook; Bae, Yong Chul | Kyungpook Natl Univ, Sch Dent, Dept Anat Physiol & Neurobiol, Daegu, South Korea; Univ Texas Hlth Sci Ctr San Antonio, Sch Dent, Dept Oral & Maxillofacial Surg, Programs Integrated Biomed Sci, San Antonio, TX 78229 USA; Univ Texas Hlth Sci Ctr San Antonio, Sch Dent, Programs Translat Sci, Dept Oral & Maxillofacial Surg, San Antonio, TX USA; Univ Texas Hlth Sci Ctr San Antonio, Sch Dent, Dept Oral & Maxillofacial Surg, Programs Biomed Engn, San Antonio, TX USA; Univ Texas Hlth Sci Ctr San Antonio, Sch Dent, Dept Oral & Maxillofacial Surg, Programs Radiol Sci, San Antonio, TX USA | Kim, Sang-Gyu/T-5925-2017; Ko, Hyoung-Gon/KQU-8680-2024; Kim, Hyongbum/D-5804-2019 | 23979595700; 36061836400; 7005252239; 56007893500; 14522654800; 55268279500; 23037541600; 56377838800 | ycbae@knu.ac.kr; | FRONTIERS IN NEUROANATOMY | FRONT NEUROANAT | 1662-5129 | 17 | SCIE | ANATOMY & MORPHOLOGY;NEUROSCIENCES | 2023 | 2.1 | 20.5 | 0.74 | 2025-06-25 | 4 | 4 | satellite glial cell; trigeminal; orofacial; glutamate; neuropathic pain | ELECTRON-MICROSCOPIC IMMUNOCYTOCHEMISTRY; GAMMA-AMINOBUTYRIC ACID; DORSAL-HORN; EXPRESSION; RELEASE; NEURONS; TRANSPORTERS; INFLAMMATION; SENSITIZATION; ACTIVATION | glutamate; neuropathic pain; orofacial; satellite glial cell; trigeminal | calcitonin gene related peptide; glutamic acid; ionomycin; ketamine; xylazine; animal cell; animal experiment; animal model; animal tissue; Article; chronic constriction injury; controlled study; craniofacial surgery; electron microscopy; endothelium cell; experimental neuropathic pain; gap junction; immunocytochemistry; immunofluorescence assay; immunogold labeling; immunohistochemistry; infraorbital nerve; male; mechanical allodynia; mechanoreceptor; nerve excitability; neuromuscular junction; nociceptive pain; nonhuman; rat; release assay; satellite glial cell; sensory nerve cell; signal transduction; trigeminus ganglion | English | 2023 | 2023-12-14 | 10.3389/fnana.2023.1302373 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Morpho-physiological and biochemical response of rice (Oryza sativa L.) to drought stress: A review | Global food shortages are caused mainly by drought, the primary driver of yield loss in agriculture worldwide. Drought stress negatively impacts the physiological and morphological characteristics of rice (Oryza sativa L.), limiting the plant productivity and hence the economy of global rice production. Physiological changes due to drought stress in rice include constrained cell division and elongation, stomatal closure, loss of turgor adjustment, reduced photosynthesis, and lower yields. Morphological changes include inhibition of seed germination, reduced tillers, early maturity, and reduced biomass. In addition, drought stress leads to a metabolic alteration by increasing the buildup of reactive oxygen species, reactive stress metabolites, antioxidative enzymes, and abscisic acid. Rice tends to combat drought through three major phenomena; tolerance, avoidance, and escape. Several mitigation techniques are introduced and adapted to combat drought stress which includes choosing drought-tolerant cultivars, planting early types, maintaining adequate moisture levels, conventional breeding, molecular maintenance, and creating variants with high-yielding characteristics. This review attempts to evaluate the various morphophysiological responses of the rice plant to drought, along with drought stress reduction techniques. | Bhandari, Utsav; Gajurel, Aakriti; Khadka, Bharat; Thapa, Ishwor; Chand, Isha; Bhatta, Dibya; Poudel, Anju; Pandey, Meena; Shrestha, Suraj; Shrestha, Jiban | Tribhuvan Univ, Inst Agr & Anim Sci, Lamjung Campus, Sundarbazar, Nepal; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Tennessee State Univ, Otis L Floyd Nursery Res Ctr, Dept Agr & Environm Sci, 472 Cadillac Lane, Mcminnville, TN 37110 USA; Tribhuvan Univ, Inst Agr & Anim Sci, Paklihawa Campus, Bhairahawa, Nepal; Agr & Forestry Univ, Rampur, Chitwan, Nepal; Nepal Agr Res Council, Natl Plant Breeding & Genet Res Ctr, Lalitpur, Khumaltar, Nepal | ; Pandey, Meena/GOJ-7653-2022; Shrestha, Jiban/AAD-1778-2020; Poudel, Anju/HLG-3959-2023; Bhandari, Utsav/LKK-0160-2024; Shrestha, Suraj/JPL-6413-2023 | 58114668500; 58114668600; 58115807700; 58707736500; 58115043900; 59325593600; 58059925700; 50262902800; 58073564600; 57221769055 | utsavbhandari103@gmail.com;gajurelaaku@gmail.com;khadkabharat28@gmail.com;ishworthapa312@gmail.com;ishachand999@gmail.com;divine@knu.ac.kr;anjupoudel65@gmail.com;pandeymeena999@gmail.com;suraz.stha07@gmail.com;jibshrestha@gmail.com; | HELIYON | HELIYON | 2405-8440 | 9 | 3 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.4 | 20.5 | 2.77 | 2025-06-25 | 42 | 53 | Drought; Morphology; Physiology; Rice; Yield | WATER-SUPPLY CONDITIONS; GRAIN-YIELD QTLS; MAPPING QTLS; ROOT MORPHOLOGY; OSMOTIC ADJUSTMENT; PLANT-RESPONSES; TOLERANCE; TRAITS; UPLAND; GROWTH | Drought; Morphology; Physiology; Rice; Yield | English | 2023 | 2023-03 | 10.1016/j.heliyon.2023.e13744 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Nitazoxanide and quercetin co-loaded nanotransfersomal gel for topical treatment of cutaneous leishmaniasis with macrophage targeting and enhanced anti-leishmanial effect | Purpose: Anti-leishmanial medications administered by oral and parenteral routes are less effective for treatment of cutaneous leishmaniasis (CL) and cause toxicity, hence targeted drug delivery is an efficient way to improve drug availability for CL with reduced toxicity. This study aimed to develop, characterize and evaluate nitazoxanide and quercetin co-loaded nanotransfersomal gel (NTZ-QUR-NTG) for the treatment of CL.Methods: NTZ-QUR-NT were prepared by thin film hydration method and were statistically optimized using Box-Behnken design. To ease the topical delivery and enhance the retention time, the NTZ-QUR-NT were dispersed in 2 % chitosan gel. Moreover, in-vitro drug release, ex-vivo permeation, macrophage uptake, cytotoxicity and anti-leishmanial assays were performed.Results: The optimized formulation indicated mean particle size 210 nm, poly dispersity index (PDI) 0.16, zeta potential (ZP) -15.1 mV and entrapment efficiency (EE) of NTZ and QUR was 88 % and 85 %, respectively. NTZ-QUR-NT and NTZ-QUR-NTG showed sustained release of the incorporated drugs as compared to the drug dispersions. Skin permeation of NTZ and QUR in NTZ-QUR-NTG was 4 times higher in comparison to the plain gels. The NTZ-QUR-NT cell internalization was almost 10-folds higher than NTZ-QUR dispersion. The cytotoxicity potential (CC50) of NTZ-QUR-NT (71.95 +/- 3.32 mu g/mL) was reduced as compared to NTZ-QUR dispersion (49.77 +/- 2.15 mu g/mL. A synergistic interaction was found between NTZ and QUR. Moreover, invitro anti-leishmanial assay presented a lower IC50 value of NTZ-QUR-NT as compared to NTZQUR dispersion. Additionally, a significantly reduced lesion size was observed in NTZ-QURNTG treated BALB/c mice, indicating its antileishmanial potential. | Bashir, Sidra; Shabbir, Kanwal; Din, Fakhar ud; Khan, Saif Ullah; Ali, Zakir; Khan, Barkat Ali; Kim, Dong Wuk; Khan, Gul Majid | Quaid I Azam Univ, Fac Biol Sci, Dept Pharm, Nanomed Res Grp, Islamabad, Pakistan; Quaid I Azam Univ, Fac Biol Sci, Dept Pharm, Islamabad, Pakistan; Bacha Khan Univ, Inst Biotechnol & Microbiol, Charsadda, Kpk, Pakistan; Gomal Univ, Drugs Design & Cosmet Lab DDCL, Fac Pharm, Dera Ismail Khan, Pakistan; Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Islamia Coll Univ, Dept Zool, Peshawar, Khyber Pakhtunk, Pakistan | KHAN, GUL MAJID/G-5739-2011; Khan, Barkat/AAK-7438-2020; Din, Fakhar-Ud-/AAR-1034-2020; Khan, Gul Majid/G-5739-2011; Din, Fakhar Ud/AAR-1034-2020 | 58085971000; 57213144986; 55905043600; 57776794700; 57220181998; 36504406600; 57193445049; 56501519000 | fudin@qau.edu.pk;gmkhan@qau.edu.pk; | HELIYON | HELIYON | 2405-8440 | 9 | 11 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.4 | 20.5 | 1.42 | 2025-06-25 | 13 | 13 | Cutaneous leishmaniasis; Nitazoxanide; Quercetin; Transfersomes; Macrophage targeting | SOLID LIPID NANOPARTICLES; DRUG-DELIVERY SYSTEMS; IN-VITRO; TRANSDERMAL DELIVERY; SKIN PERMEATION; TRANSFERSOMES; LIPOSOMES; EFFICACY; VIVO; MILTEFOSINE | Cutaneous leishmaniasis; Macrophage targeting; Nitazoxanide; Quercetin; Transfersomes | English | 2023 | 2023-11 | 10.1016/j.heliyon.2023.e21939 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Prediction of strawberry yield based on receptacle detection and Bayesian inference | The receptacle of strawberry is a more direct part than the flower for predicting yield as they eventually become fruits. Thus, we tried to predict the yield by combining an AI technique for receptacle detection in images and statistical analysis on the relationship between the number of receptacles detected and the strawberry yield over a period of time. Five major cultivars were cultivated to consider the cultivar characteristics and environmental factors for two years were collected to consider the climate difference. Faster R-CNN based object detector was used to estimate the number of receptacles per strawberry plant in given two-dimensional images, which achieved a mAP of 0.6587 for our dataset. However, not all receptacles appear on the two-dimensional images, and Bayesian analysis was used to model the uncertainty associated with the number of receptacles missed by the AI. After estimating the probability of fruiting per receptacle, prediction models for the total strawberry yield at the end of harvest season were evaluated. Even though the detection accuracy was not perfect, the results indicated that counting the receptacles by object detection and estimating the probability of fruiting per receptacle by Bayesian modeling are more useful for predicting the total yield per plant than knowing its cu-mulative yield during the first month. | Yoon, Sunghyun; Jo, Jung Su; Kim, Steven B.; Sim, Ha Seon; Kim, Sung Kyeom; Kim, Dong Sub | Kongju Natl Univ, Dept Artificial Intelligence, Cheonan 31080, South Korea; Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Hort Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea; Calif State Univ, Dept Math & Stat, Monterey Bay, Seaside, CA 93955 USA; Kongju Natl Univ, Dept Hort, Yesan 32439, South Korea | Kim, Dong/G-7392-2017; Kim, Steven/HSH-9295-2023; Kim, Sung Kyeom/AAD-9230-2019 | 57189589293; 57197337268; 55243558900; 57220890640; 50262290200; 15760138600 | skkim76@knu.ac.kr;dongsub@kongju.ac.kr; | HELIYON | HELIYON | 2405-8440 | 9 | 3 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.4 | 20.5 | 0.83 | 2025-06-25 | 8 | 7 | Bayesian statistical analysis; Faster R -CNN; Object detection; Receptacle; Two seasons | GROWTH; SEASON | Bayesian statistical analysis; Faster R–CNN; Object detection; Receptacle; Two seasons | English | 2023 | 2023-03 | 10.1016/j.heliyon.2023.e14546 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Protective effects of cell permeable Tat-PIM2 protein on oxidative stress induced dopaminergic neuronal cell death | Background: Oxidative stress is considered as one of the main causes of Parkinson's disease (PD), however the exact etiology of PD is still unknown. Although it is known that Proviral Integration Moloney-2 (PIM2) promotes cell survival by its ability to inhibit formation of reactive oxygen species (ROS) in the brain, the precise functional role of PIM2 in PD has not been fully studied yet. Objective: We investigated the protective effect of PIM2 against apoptosis of dopaminergic neuronal cells caused by oxidative stress-induced ROS damage by using the cell permeable TatPIM2 fusion protein in vitro and in vivo. Methods: Transduction of Tat-PIM2 into SH-SY5Y cells and apoptotic signaling pathways were determined by Western blot analysis. Intracellular ROS production and DNA damage was confirmed by DCF-DA and TUNEL staining. Cell viability was determined by MTT assay. PD animal model was induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and protective effects were examined using immunohistochemistry. Results: Transduced Tat-PIM2 inhibited the apoptotic caspase signaling and reduced the production of ROS induced by 1-methyl-4-phenylpyridinium (MPP+) in SH-SY5Y cells. Furthermore, we confirmed that Tat-PIM2 transduced into the substantia nigra (SN) region through the bloodbrain barrier and this protein protected the Tyrosine hydroxylase-positive cells by observation of immunohistostaining. Tat-PIM2 also regulated antioxidant biomolecules such as SOD1, catalase, 4-HNE, and 8-OHdG which reduce the formation of ROS in the MPTP-induced PD mouse model. Conclusion: These results indicated that Tat-PIM2 markedly inhibited the loss of dopaminergic neurons by reducing ROS damage, suggesting that Tat-PIM2 might be a suitable therapeutic agent for PD. | Shin, Min Jea; Eum, Won Sik; Youn, Gi Soo; Park, Jung Hwan; Yeo, Hyeon Ji; Yeo, Eun Ji; Kwon, Hyun Jung; Sohn, Eun Jeong; Lee, Lee Re; Kim, Na Yeon; Kwon, Su Yeon; Kim, Su Min; Jung, Hyo Young; Kim, Duk-Soo; Cho, Sung -Woo; Kwon, Oh-Shin; Kim, Dae Won; Choi, Soo Young | Hallym Univ, Dept Biomed Sci, Chunchon 24252, South Korea; Hallym Univ, Res Inst Biosci & Biotechnol, Chunchon 24252, South Korea; Gangneung Wonju Natl Univ, Res Inst Oral Sci, Coll Dent, Dept Biochem & Mol Biol, Kangnung 25457, South Korea; Chungnam Natl Univ, Dept Vet Med, Daejeon 34134, South Korea; Chungnam Natl Univ, Inst Vet Sci, Daejeon 34134, South Korea; Soonchunhyang Univ, Coll Med, Dept Anat, Cheonan Si 31538, South Korea; Soonchunhyang Univ, Coll Med, BK21 FOUR Project, Cheonan Si 31538, South Korea; Univ Ulsan, Coll Med, Dept Biochem & Mol Biol, Seoul 05505, South Korea; Kyungpook Natl Univ, Sch Life Sci, Coll Nat Sci, Taegu 41566, South Korea | lee, lee/KHW-4323-2024; Kim, Su Min/HOA-9063-2023; Kim, Nam Hoon/HNS-5794-2023 | 35485651200; 6602752494; 54894334000; 57190766857; 55894879100; 56406995100; 57190062260; 36903841600; 57224568196; 57226179942; 58093198400; 58174842500; 55798391300; 23089792500; 57190428583; 7402195859; 56194913400; 56912545700 | kimdw@gwnu.ac.kr;sychoi@hallym.ac.kr; | HELIYON | HELIYON | 2405-8440 | 9 | 5 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.4 | 20.5 | 0.12 | 2025-06-25 | 1 | 1 | Tat-PIM2; Parkinson's disease; Oxidative stress; ROS; Apoptosis; Protein transduction; Protein therapy | PARKINSONS-DISEASE; PIM KINASES; IN-VITRO; MECHANISMS; DELIVERY; ACTIVATION; TRANSPORT; GROWTH; BRAIN; BODY | Apoptosis; Oxidative stress; Parkinson's disease; Protein therapy; Protein transduction; ROS; Tat-PIM2 | English | 2023 | 2023-05 | 10.1016/j.heliyon.2023.e15945 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Relationships among self-esteem, ego-resilience, and caregiver burden among families of children with hematologic and oncologic disease: A cross-sectional study | Background: Pediatric hematology and oncology disease is a physically and emotionally demanding health condition for families. High self-esteem and ego-resilience among caregivers, which have recently gained increased recognition, might help ease caregiver burdens. Few studies, however, have simultaneously investigated the relationships between self-esteem, ego-resilience, and caregiver burden among caregivers of children with hematologic and oncologic disease.Objective: The purpose of this study is to investigate the relationships between caregiver burden, self-esteem, and ego-resilience and examine whether ego-resilience plays a role in mediating the relationship between self-esteem and caregiver burden among family caregivers of children with hematologic and oncologic disease.Design: Descriptive correlational study.Setting: The outpatient clinic of the department of pediatric hematology and oncology at a flagship university hospital in a metropolitan city in South Korea.Participants: The sample comprised 109 primary family caregivers of children with hematologic and oncologic disease. Convenience sampling method was used.Methods: The participants completed the Ego-Resiliency Scale, Rosenberg Self-Esteem Scale, and Family Burden Questionnaire. One-way analysis of variance, independent t-tests, and correlation analyses were conducted using IBM SPSS 25.0. The mediating effect of ego-resilience was estimated using the PROCESS macro and bootstrap method in SPSS.Results: Caregiver burden showed significant negative associations with self-esteem and ego-resilience, with moderate effect sizes (r = -.391 and -0.361, respectively, p = .001). Ego-resilience mediated the relationship between self-esteem and caregiver burden (b = -0.019; 95 % bias-corrected bootstrap confidence interval -0.035 and -0.001). Conclusions: Self-esteem and ego-resilience may lessen caregiver burden among families of children with hematologic and oncologic disease, and self-esteem of caregivers tends to promote their ego-resilience. Therefore, self-esteem and ego-resilience should be improved among family caregivers to reduce their caregiver burden. | Kim, Ji Yoon; Park, Bu Kyung | Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Kyungpook Natl Univ, Coll Nursing, Daegu, South Korea | 57205408095; 57199829070 | bukpark@knu.ac.kr; | HELIYON | HELIYON | 2405-8440 | 9 | 12 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.4 | 20.5 | 0.24 | 2025-06-25 | 2 | 2 | Caregiver burden; Ego-resilience; Self-esteem; Childhood cancer | SOUTH-KOREA; HEALTH; ADULTS | Caregiver burden; Childhood cancer; Ego-resilience; Self-esteem | English | 2023 | 2023-12 | 10.1016/j.heliyon.2023.e22652 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | The criteria of Chinese and South Koreans? mate selection: A comparative study of long-term and short-term mate selection preferences in the cross-cultural perspective | Sexual selection has become an important research topic in behavioral ecology, human behavior, and evolution. The study of mate selection preferences across cultures and countries has gradually received increasing attention. The present study was aimed to reveal the differences of long-term and short-term mate selection preferences between young people in Chinese and South Korean. An questionnaire survey method was followed to obtain the aim of the study, and a total of 273 Chinese (M = 22.07, SD = 1.75) and 181 Koreans (M = 21.75, SD = 2.05) unmarried university students were chosen to participate the study. We summarized the important core factors of in-dividual mate preferences and revealed the long-term and short-term mate preferences of young men and women in both countries through quantitative analysis. The results indicated that ed-ucation played a crucial role in the long-term mate selection for both Chinese males and females. Contrastingly, Koreans valued friendliness and easygoingness in long-term mate value and live-liness in short-term mate value. There were differences found in mate preference by gender be-tween Chinese and Koreans, influenced by cross-cultural factors. These findings strongly supported cultural differences in mate selection and provided practical suggestions for future cross-cultural mate selection research. | Lu, Yunhang | Kyungpook Natl Univ, Dept Phys Educ, Daegu 41566, South Korea | 57262012200 | yunhangluck@163.com; | HELIYON | HELIYON | 2405-8440 | 9 | 2 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.4 | 20.5 | 0.47 | 2025-06-25 | 2 | 4 | Mate selection; Mate preferences; Cross-cultural; Gender differences; Cultural differences; Confucianism | SEXUAL SELECTION; PARENTAL INVESTMENT; MENS PREFERENCES; UNITED-STATES; GENDER; EVOLUTIONARY; POLITICS; STRATEGIES; STUDENTS; WOMEN | Confucianism; Cross-cultural; Cultural differences; Gender differences; Mate preferences; Mate selection | English | 2023 | 2023-02 | 10.1016/j.heliyon.2023.e13329 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Aging Hardening and Precipitation Characteristics of Extruded Mg-9Al-0.8Zn-0.2Mn-0.3Ca-0.2Y Alloy | In this study, an Mg-9Al-0.8Zn-0.2Mn-0.3Ca-0.2Y (AZXW9100) alloy having high corrosion and ignition resistance characteristics is recently developed. This study investigates the aging hardening and Mg17Al12 precipitation characteristics of the extruded AZXW9100 alloy by comparing those of a commercial AZ91 counterpart. Both alloys' microstructures consist of equiaxed recrystallized grains and they have an intense basal texture. Unlike the AZ91 alloy with a few Al-Mn particles, the AZXW9100 alloy contains numerous Al2Y, Al8Mn4Y, and Al2Ca particles. As the aging time increases from 0 to 8 h at 200 degrees C, the hardness increases from 63.6 to 95.4 Hv and 68.8 to 98.3 Hv for the AZ91 and AZXW9100 alloys, respectively. Although the hardness increments during aging and the peak aging times are almost the same for both alloys, their Mg17Al12 precipitation behavior considerably differs. During aging, the number of Mg17Al12 continuous precipitates formed in the AZXW9100 alloy is less than that in the AZ91 alloy because of the lower amount of Al solute atoms in the former. The nucleation and growth of Mg17Al12 discontinuous precipitates (DPs) are also suppressed in the AZXW9100 alloy because of the combined effect by the reduced Al solutes, finer grains, Ca and Y solutes, and second-phase particles. Consequently, the area fraction of DPs of the peak-aged AZXW9100 alloy is nearly half that of the peak-aged AZ91 alloy. This study demonstrates that adding small amounts of Ca and Y to AZ91 alloy causes drastic variations in the Mg17Al12 precipitation behavior during aging. | Kim, Hyun Ji; Kim, Young Min; Bae, Jun Ho; Yoon, Jonghun; Park, Sung Hyuk | Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Korea Inst Mat Sci, Implementat Res Div, Chang Won 51508, South Korea; Hanyang Univ, Dept Mech Engn, Ansan 15588, South Korea | Park, Sung-Hyuk/AAE-6726-2022; Kim, Young Min/HCH-5414-2022; Kim, Hyunjin/MDS-5282-2025 | 59866513600; 58795669000; 36900467300; 56449838900; 54786002500 | sh.park@knu.ac.kr; | METALS AND MATERIALS INTERNATIONAL | MET MATER INT | 1598-9623 | 2005-4149 | 29 | 2 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2023 | 3.3 | 20.6 | 1.86 | 2025-06-25 | 14 | 14 | Magnesium; Aging; Precipitation; Microstructure; Hardness | AL-ZN ALLOY; MECHANICAL-PROPERTIES; MAGNESIUM; BEHAVIOR; MICROSTRUCTURE; AZ91; TEMPERATURE; ADDITIONS; CA; EXTRUSION | Aging; Hardness; Magnesium; Microstructure; Precipitation | Age hardening; Aluminum; Aluminum alloys; Aluminum corrosion; Binary alloys; Calcium; Calcium alloys; Hardness; Magnesium; Magnesium alloys; Manganese alloys; Textures; Ageing hardening; Aging precipitation; Aging time; AZ91 alloy; Discontinuous precipitates; Ignition resistances; Peak aged; Precipitation behaviour; Precipitation characteristics; Resistance characteristics; Precipitation (chemical) | English | 2023 | 2023-02 | 10.1007/s12540-022-01237-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Changing trends and characteristics of peptic ulcer disease: A multicenter study from 2010 to 2019 in Korea | BACKGROUND The clinical trend and characteristics of peptic ulcer disease (PUD) have not fully been investigated in the past decade.AIM To evaluate the changing trends and characteristics of PUD according to age and etiology.METHODS We analyzed seven hospital databases converted into the Observational Medical Outcomes Partnership-Common Data Model between 2010 and 2019. We classified patients with PUD who underwent rapid urease tests or Helicobacter pylori (H. pylori) serology into three groups: H. pylori-related, drug [nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin]-related, and idiopathic (H. pylori/NSAID/aspirin-negative) PUD and compared the yearly trends and characteristics among the three groups.RESULTS We included 26785 patients in 7 databases, and the proportion of old age (>= 65 years) was 38.8%. The overall number of PUD exhibited no decrease, whereas PUD in old age revealed an increasing trend (P = 0.01 for trend). Of the 19601 patients, 41.8% had H. pylori-related, 36.1% had drug-related, and 22.1% had idiopathic PUD. H. pylori-related PUD exhibited a decreasing trend after 2014 (P = 0.01), drug-related PUD demonstrated an increasing trend (P = 0.04), and idiopathic PUD showed an increasing trend in the old-age group (P = 0.01) during 10 years. Patients with drug-related PUD had significantly more comorbidities and concomitant ulcerogenic drugs. The idiopathic PUD group had a significantly higher number of patients with chronic liver disease.CONCLUSION With the aging population increase, the effects of concomitant ulcerogenic drugs and preventive strategies should be investigated in drug-induced PUD. Further studies are required to clarify the relationship between idiopathic PUD and chronic liver disease. | Choi, Yoon Jin; Kim, Tae Jun; Bang, Chang Seok; Lee, Yong Kang; Lee, Moon Won; Nam, Su Youn; Shin, Woon Geon; Seo, Seung In | Natl Canc Ctr, Dept Internal Med, Goyang Si 13620, South Korea; Samsung Med Ctr, Dept Internal Med, Div Cardiol, Seoul 06351, South Korea; Chuncheon Sacred Heart Hosp, Dept Internal Med, Chunchon 24253, South Korea; Natl Hlth Insurance Serv Ilsan Hosp, Dept Internal Med, Goyang Si 10444, South Korea; Pusan Natl Univ, Dept Internal Med, Sch Med, Busan 50463, South Korea; Kyungpook Natl Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Chilgok Hosp, Daegu 41404, South Korea; Hallym Univ, Kangdong Sacred Heart Hosp, Dept Internal Med, Coll Med, Seoul 05355, South Korea; Hallym Univ, Inst Liver & Digest Dis, Chunchon 24253, South Korea; Kangdong Sacred Heart Hosp, Dept Internal Med, Div Gastroenterol, 150 Seongan Ro, Seoul 05355, South Korea | Bang, Chang SEOK/I-9689-2019; Lee, Yoojin/AAB-9799-2022; Lee, Yeong Yeh/G-2470-2010 | 57209841798; 57189389501; 57991522300; 55541067600; 56242245200; 55617028500; 13606883400; 56537576000 | doctorssi@kdh.or.kr; | WORLD JOURNAL OF GASTROENTEROLOGY | WORLD J GASTROENTERO | 1007-9327 | 2219-2840 | 29 | 44 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 4.3 | 20.6 | 0.59 | 2025-06-25 | 4 | 3 | Peptic ulcer disease; Drug; Idiopathic; Trend; Characteristics | HELICOBACTER-PYLORI INFECTION; CLINICAL CHARACTERISTICS; HOSPITALIZATION; RISK | Characteristics; Drug; Idiopathic; Peptic ulcer disease; Trend | Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Helicobacter Infections; Helicobacter pylori; Humans; Liver Diseases; Peptic Ulcer; Republic of Korea; acetylsalicylic acid; antidepressant agent; antithrombocytic agent; bisphosphonic acid derivative; cilostazol; clopidogrel; immunosuppressive agent; nonsteroid antiinflammatory agent; prasugrel; steroid; ticagrelor; ticlopidine; triflusal; warfarin; acetylsalicylic acid; nonsteroid antiinflammatory agent; aged; Article; chronic liver disease; clinical feature; clinical outcome; comorbidity; controlled study; data analysis; data base; female; groups by age; Helicobacter infection; human; idiopathic disease; major clinical study; male; multicenter study; pathogenesis; peptic ulcer; retrospective study; serology; South Korea; trend study; adult; aging; article; Helicobacter pylori; Korea; middle aged; peptic ulcer; rapid urease test; therapy; young adult | English | 2023 | 2023-11-28 | 10.3748/wjg.v29.i44.5882 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Implications of recent neoadjuvant clinical trials on the future practice of radiotherapy in locally advanced rectal cancer | Over the last two decades, the standard treatment for locally advanced rectal cancer (LARC) has been neoadjuvant chemoradiotherapy plus total mesorectal excision followed by adjuvant chemotherapy. Total neoadjuvant treatment (TNT) and immunotherapy are two major issues in the treatment of LARC. In the two latest phase III randomized controlled trials (RAPIDO and PRODIGE23), the TNT approach achieved higher rates of pathologic complete response and distant metastasis-free survival than conventional chemoradiotherapy. Phase I/II clinical trials have reported promising response rates to neoadjuvant (chemo)-radiotherapy combined with immunotherapy. Accordingly, the treatment paradigm for LARC is shifting toward methods that increase the oncologic outcomes and organ preservation rate. However, despite the progress of these combined modality treatment strategies for LARC, the radiotherapy details in clinical trials have not changed significantly. To guide future radiotherapy for LARC with clinical and radiobiological evidence, this study reviewed recent neoadjuvant clinical trials evaluating TNT and immunotherapy from a radiation oncologist's perspective. | Kang, Min Kyu | Kyungpook Natl Univ, Sch Med, Dept Radiat Oncol, Daegu 41944, South Korea; Kyungpook Natl Univ Chilgok Hosp, Dept Radiat Oncol, Daegu 40414, South Korea; Kyungpook Natl Univ Chilgok Hosp, Dept Radiat Oncol, 807 Hoguk Ro, Daegu 40414, South Korea | KANG, MIN KYU/ACI-8824-2022 | 57201933342 | mkkang@knu.ac.kr; | WORLD JOURNAL OF GASTROENTEROLOGY | WORLD J GASTROENTERO | 1007-9327 | 2219-2840 | 29 | 6 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 4.3 | 20.6 | 0.61 | 2025-06-25 | 8 | 7 | Rectal cancer; Neoadjuvant therapy; Radiotherapy; Total neoadjuvant treatment; Immunotherapy | TOTAL MESORECTAL EXCISION; PHASE-III TRIAL; PREOPERATIVE CHEMORADIOTHERAPY; ADJUVANT CHEMOTHERAPY; OPEN-LABEL; RADIATION-THERAPY; POSTOPERATIVE CHEMORADIOTHERAPY; CONSOLIDATION CHEMOTHERAPY; COLORECTAL-CANCER; SURVIVAL OUTCOMES | Immunotherapy; Neoadjuvant therapy; Radiotherapy; Rectal cancer; Total neoadjuvant treatment | Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Combined Modality Therapy; Humans; Neoadjuvant Therapy; Neoplasm Staging; Rectal Neoplasms; Rectum; immune checkpoint inhibitor; antineoplastic agent; advanced cancer; cancer immunotherapy; cancer localization; clinical practice; distant metastasis free survival; human; neoadjuvant chemoradiotherapy; organ preservation; phase 1 clinical trial (topic); phase 2 clinical trial (topic); phase 3 clinical trial (topic); randomized controlled trial (topic); rectum cancer; Review; treatment response; adverse event; cancer staging; chemoradiotherapy; multimodality cancer therapy; neoadjuvant therapy; pathology; procedures; rectum; rectum tumor | English | 2023 | 2023-02-14 | 10.3748/wjg.v29.i6.1011 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Infliximab vs adalimumab: Points to consider when selecting anti-tumor necrosis factor agents in pediatric patients with Crohn's disease | Biologic agents with various mechanisms against Crohn's disease (CD) have been released and are widely used in clinical practice. However, two anti-tumor necrosis factor (TNF) agents, infliximab (IFX) and adalimumab (ADL), are the only biologic agents approved by the Food and Drug Administration for pediatric CD currently. Therefore, in pediatric CD, the choice of biologic agents should be made more carefully to achieve the therapeutic goal. There are currently no head-to-head trials of biologic agents in pediatric or adult CD. There is a lack of accumulated data for pediatric CD, which requires the extrapolation of adult data for the positioning of biologics in pediatric CD. From a pharmacokinetic point of view, IFX is more advantageous than ADL when the inflammatory burden is high, and ADL is expected to be advantageous over IFX in sustaining remission in the maintenance phase. Additionally, we reviewed the safety profile, immunogenicity, preference, and compliance between IFX and ADL and provide practical insights into the choice of anti-TNF therapy in pediatric CD. Careful evaluation of clinical indications and disease behavior is essential when prescribing anti-TNF agents. In addition, factors such as the efficacy of induction and maintenance of remission, safety profile, immunogenicity, patient preference, and compliance play an important role in evaluating and selecting treatment options. | Kim, Eun Sil; Kang, Ben | Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Dept Pediat, Seoul 03181, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, 680 Gukchaebosang Ro, Daegu 41944, South Korea | Kim, Nam-Joong/J-2735-2012; 康, 奔/JMQ-0812-2023 | 57205500267; 57194823199 | benkang@knu.ac.kr; | WORLD JOURNAL OF GASTROENTEROLOGY | WORLD J GASTROENTERO | 1007-9327 | 2219-2840 | 29 | 18 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 4.3 | 20.6 | 0.2 | 2025-06-25 | 2 | 2 | Anti-tumor necrosis factor; Infliximab; Adalimumab; Crohn's disease; Pediatric | INFLAMMATORY-BOWEL-DISEASE; POST-HOC ANALYSIS; ANTI-TNF THERAPY; COMBINATION THERAPY; TROUGH LEVELS; FACTOR-ALPHA; MAINTENANCE INFLIXIMAB; ADALIMUMAB MONOTHERAPY; DECISION-MAKING; CHILDREN | Adalimumab; Anti-tumor necrosis factor; Crohn’s disease; Infliximab; Pediatric | Adalimumab; Adult; Biological Factors; Child; Crohn Disease; Humans; Infliximab; Necrosis; Pediatric Crohn's disease; Treatment Outcome; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; adalimumab; immunomodulating agent; infliximab; interleukin 12; interleukin 23; tumor necrosis factor; ustekinumab; vedolizumab; adalimumab; biological factor; infliximab; tumor necrosis factor; tumor necrosis factor inhibitor; Crohn disease; drug efficacy; drug safety; human; immunogenicity; pediatric patient; randomized controlled trial (topic); Review; adult; child; Crohn disease; necrosis; pathology; treatment outcome | English | 2023 | 2023-05-14 | 10.3748/wjg.v29.i18.2784 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Tensile and High-Cycle Fatigue Properties of Die-Cast SEN6 Magnesium Alloy | This study investigates the microstructural characteristics, tensile properties, and high-cycle fatigue properties of a die-cast Mg-6Al-0.1Mn-0.1Zn-0.3Ca-0.2Y (SEN6) alloy with high corrosion and ignition resistances. The average grain size of an hourglass-shaped die-cast specimen of the SEN6 alloy is smaller at the surface region (similar to 7 mu m) compared to the center region (12-15 mu m) due to the higher cooling rate at the surface region. Four types of pores with different sizes and roundness features, namely, gas pores, island-shrinkage pores, gas-shrinkage pores, and net-shrinkage pores, are distributed throughout the specimen. The presence of small amounts of Ca and Y in the SEN6 alloy results in the formation of Al2Ca, Al8Mn4Y, and Al2Y particles. Coarse Mg17Al12 and Al2Ca particles are present along the grain boundaries, and relatively fine Al8Mn4Y and Al2Y particles are distributed inside the grains. The die-cast SEN6 alloy exhibits a tensile yield strength of 121.4 MPa, ultimate tensile strength (UTS) of 172.5 MPa, elongation of 5.1%, and fatigue limit (FL) of 50 MPa. The island-shrinkage and net-shrinkage pores act as crack initiation sites during tension owing to their irregular shape and sharp tips. In contrast, fatigue cracks initiate at the gas-shrinkage pores and Al2Ca particles present at the sub-surface. Larger gas-shrinkage pores located closer to the surface induce higher stress concentration around them during cyclic loading. The high hardness of Al2Ca particles causes a significant difference in micro-plasticity between the alpha-Mg matrix and the particles, leading to the formation of fatigue cracks. The FL and UTS of die-cast Mg alloys are linearly related: FL = 0.74 x UTS - 73.5; this relationship is observed in the die-cast SEN6 alloy as well. | Kim, Jung Eun; Kim, Ye Jin; Bae, Jun Ho; You, Bong Sun; Park, Sung Hyuk | Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Korea Inst Mat Sci, Dept Magnesium, Chang Won 51508, South Korea | Park, Sung-Hyuk/AAE-6726-2022 | 57968306900; 59052467200; 36900467300; 55664007600; 54786002500 | sh.park@knu.ac.kr; | METALS AND MATERIALS INTERNATIONAL | MET MATER INT | 1598-9623 | 2005-4149 | 29 | 12 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2023 | 3.3 | 20.6 | 1.33 | 2025-06-25 | 11 | 10 | Magnesium alloy; Die-casting; Microstructure; Tensile properties; High-cycle fatigue properties | MECHANICAL-PROPERTIES; BEHAVIOR; CORROSION; POROSITY; MICROSTRUCTURE; RESISTANCE; VACUUM; AZ91D; SIZE; LIFE | Die-casting; High-cycle fatigue properties; Magnesium alloy; Microstructure; Tensile properties | Aluminum alloys; Binary alloys; Cracks; Die casting; Grain boundaries; High-cycle fatigue; Low-cycle fatigue; Magnesium castings; Manganese alloys; Shrinkage; Stress analysis; Tensile strength; Ternary alloys; Average grain size; Die-cast; Fatigue cracks; Fatigue Limit; High cycle fatigue properties; Ignition resistances; Microstructural characteristics; Shrinkage pores; Surface region; Ultimate tensile strength; Magnesium alloys | English | 2023 | 2023-12 | 10.1007/s12540-023-01473-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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