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| ○ | ○ | Article | Head and neck dermatitis is exacerbated by Malassezia furfur colonization, skin barrier disruption, and immune dysregulation | Introduction & objectivesHead and neck dermatitis (HND) is a refractory phenotype of atopic dermatitis (AD) and can be a therapeutic challenge due to lack of responsiveness to conventional treatments. Previous studies have suggested that the microbiome and fungiome may play a role in inducing HND, but the underlying pathogenic mechanisms remain unknown. This study aimed to determine the link between HND and fungiome and to examine the contribution of Malassezia furfur. Materials and methodsTo identify the effect of the sensitization status of M. furfur on HND, 312 patients diagnosed with AD were enrolled. To elucidate the mechanism underlying the effects of M. furfur, human keratinocytes and dermal endothelial cells were cultured with M. furfur and treated with Th2 cytokines. The downstream effects of various cytokines, including inflammation and angiogenesis, were investigated by real-time quantitative PCR. To identify the association between changes in lipid composition and M. furfur sensitization status, D-squame tape stripping was performed. Lipid composition was evaluated by focusing on ceramide species using liquid chromatography coupled with tandem mass spectrometry. ResultsIncreased sensitization to M. furfur was observed in patients with HND. Additionally, sensitization to M. furfur was associated with increased disease severity in these patients. IL-4 treated human keratinocytes cultured with M. furfur produced significantly more VEGF, VEGFR, IL-31, and IL-33. IL-4/M. furfur co-cultured dermal endothelial cells exhibited significantly elevated VEGFR, TGF-beta, TNF-alpha, and IL-1 beta levels. Stratum corneum lipid analysis revealed decreased levels of esterified omega-hydroxyacyl-sphingosine, indicating skin barrier dysfunction in HND. Finally, M. furfur growth was inhibited by the addition of these ceramides to culture media, while the growth of other microbiota, including Cutibacterium acnes, were not inhibited. ConclusionsUnder decreased levels of ceramide in AD patients with HND, M. furfur would proliferate, which may enhance pro-inflammatory cytokine levels, angiogenesis, and tissue remodeling. Thus, it plays a central role in the pathogenesis of HND in AD. | Chu, Howard; Kim, Su Min; Zhang, KeLun; Wu, Zhexue; Lee, Hemin; Kim, Ji Hye; Kim, Hye Li; Kim, Yu Ri; Kim, Seo Hyeong; Kim, Wan Jin; Lee, Yang Won; Lee, Kwang Hoon; Liu, Kwang-Hyeon; Park, Chang Ook | Yonsei Univ, Severance Hosp, Cutaneous Biol Res Inst, Dept Dermatol,Coll Med, Seoul, South Korea; Yonsei Univ, Brain Korea 21 PLUS Project Med Sci, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Brain Korea 21 FOUR Community Based Intelligent No, Daegu, South Korea; Myongji Hosp, Dept Dermatol, Goyang, South Korea; Konkuk Univ, Dept Dermatol, Sch Med, Seoul, South Korea | Kim, Sumin/IZE-4757-2023; Chu, Howard/IVH-3242-2023; Lee, Jae-Hyun/ABE-3803-2020; ZHANG, KELUN/NPJ-0253-2025; Gim, Yuri/JNZ-3445-2023 | 56982338700; 57219516843; 57218193348; 55523767300; 55810034100; 57207437062; 57222151982; 56066797500; 57196226374; 57773552600; 15033490400; 6701409341; 55768214700; 57283808600 | dstlkh@knu.ac.kr;copark@yuhs.ac; | FRONTIERS IN IMMUNOLOGY | FRONT IMMUNOL | 1664-3224 | 14 | SCIE | IMMUNOLOGY | 2023 | 5.7 | 20.2 | 3.77 | 2025-06-25 | 24 | 26 | atopic dermatitis; head and neck dermatitis; Malassezia; LC-MS; MS; lipid analysis; ceramide; red face syndrome | ATOPIC-DERMATITIS; MOLECULAR ANALYSIS; IDENTIFICATION; RESTRICTA | atopic dermatitis; ceramide; head and neck dermatitis; LC-MS/MS; lipid analysis; Malassezia; red face syndrome | Ceramides; Cytokines; Dermatitis, Atopic; Endothelial Cells; Humans; Interleukin-4; Lipids; Malassezia; ceramide; immunoglobulin E; interleukin 1beta; interleukin 31; interleukin 33; interleukin 4; transforming growth factor beta; tumor necrosis factor; vasculotropin; vasculotropin receptor; cytokine; interleukin 4; lipid; adolescent; adult; angiogenesis; Article; atopic dermatitis; child; clinical/laboratory phenotype; coculture; column chromatography; dermal microvascular endothelial cell; Eczema Area and Severity Index; facial skin biopsy; female; fungal colonization; head and neck dermatitis; histology; human; human cell; human tissue; immune dysregulation; immunohistochemistry; inflammation; keratinocyte; lipid analysis; lipid composition; liquid chromatography-mass spectrometry; major clinical study; Malassezia furfur; male; mycobiome; nonhuman; phenotype; Propionibacterium acnes; quantitative analysis; real time polymerase chain reaction; RNA extraction; selected reaction monitoring; sensitization; skin biopsy; Staphylococcus epidermidis; stratum corneum; tandem mass spectrometry; vitiligo; endothelium cell; Malassezia; physiology | English | 2023 | 2023-02-22 | 10.3389/fimmu.2023.1114321 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Infliximab trough levels are associated with endoscopic healing but not with transmural healing at one year treatment with infliximab in pediatric patients with Crohn's disease | IntroductionIt is well known that infliximab (IFX) trough levels (TLs) are associated with endoscopic healing (EH) in Crohn's disease (CD). We investigated whether IFX TLs are associated with transmural healing (TH) in pediatric patients with CD following 1-year treatment. MethodsPediatric patients with CD treated with IFX were included in this single-center prospective study. IFX TL tests, magnetic resonance enterography (MRE), and colonoscopies were simultaneously conducted after 1-year IFX treatment. TH was defined as a wall thickness of & LE;3 mm without inflammatory signs evaluated using MRE. EH was defined as a Simple Endoscopic Score for Crohn's disease of ResultsFifty-six patients were included. EH and TH were observed in 60.7% (34/56) and 23.2% (13/56) of patients, respectively. IFX TLs were higher in patients with EH (median, 5.6 vs. 3.4 & mu;g/mL, P = 0.002), whereas IFX TLs showed no significant difference in patients with and without TH (median, 5.4 vs. 4.7 & mu;g/mL, P = 0.574). No significant difference was observed in EH and TH between patients whose intervals were shortened or not. Multivariate logistic regression analysis showed that IFX TLs and disease duration to IFX initiation were associated with EH (odds ratio [OR] = 1.82, P = 0.001, and OR = 0.43, P = 0.02, respectively). DiscussionIn pediatric patients with CD, IFX TLs were associated with EH but not with TH. Further studies investigating long-term TH and proactive dosing based on therapeutic drug monitoring may clarify whether an association between IFX TLs and TH exists. | Choi, So Yoon; Kwon, Yiyoung; Choi, Sujin; Lee, So Mi; Choe, Byung-Ho; Kang, Ben | Kosin Univ, Gospel Hosp, Dept Pediat, Coll Med, Busan, South Korea; Inha Univ, Sch Med, Dept Pediat, Incheon, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea | 康, 奔/JMQ-0812-2023; Choe, Byung-Ho/KSM-6251-2024 | 57207282105; 57211905573; 57223972405; 56824903400; 57574977300; 57194823199 | benkang@knu.ac.kr; | FRONTIERS IN IMMUNOLOGY | FRONT IMMUNOL | 1664-3224 | 14 | SCIE | IMMUNOLOGY | 2023 | 5.7 | 20.2 | 0.43 | 2025-06-25 | 4 | 3 | Crohn's disease; infliximab; magnetic resonance enterography; transmural healing; trough levels | INFLAMMATORY-BOWEL-DISEASE; MAGNETIC-RESONANCE ENTEROGRAPHY; MAINTENANCE INFLIXIMAB; THERAPEUTIC WINDOW; MUCOSAL; REMISSION; CHILDREN; CALPROTECTIN; PATHOGENESIS; OPPORTUNITY | Crohn’s disease; infliximab; magnetic resonance enterography; transmural healing; trough levels | Child; Colonoscopy; Crohn Disease; Gastrointestinal Agents; Humans; Infliximab; Prospective Studies; azathioprine; C reactive protein; infliximab; gastrointestinal agent; infliximab; adolescent; anastomosis; Article; body mass; colonoscopy; Crohn disease; disease duration; edema; endoscopy; follow up; healing; human; immunomodulation; magnetic resonance enterography; male; pediatric patient; phenotype; prospective study; remission; small intestine resection; thickness; ulcerative colitis; child | English | 2023 | 2023-06-23 | 10.3389/fimmu.2023.1192827 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Mitochondrial dysfunctions in T cells: focus on inflammatory bowel disease | Mitochondria has emerged as a critical ruler of metabolic reprogramming in immune responses and inflammation. In the context of colitogenic T cells and IBD, there has been increasing research interest in the metabolic pathways of glycolysis, pyruvate oxidation, and glutaminolysis. These pathways have been shown to play a crucial role in the metabolic reprogramming of colitogenic T cells, leading to increased inflammatory cytokine production and tissue damage. In addition to metabolic reprogramming, mitochondrial dysfunction has also been implicated in the pathogenesis of IBD. Studies have shown that colitogenic T cells exhibit impaired mitochondrial respiration, elevated levels of mROS, alterations in calcium homeostasis, impaired mitochondrial biogenesis, and aberrant mitochondria-associated membrane formation. Here, we discuss our current knowledge of the metabolic reprogramming and mitochondrial dysfunctions in colitogenic T cells, as well as the potential therapeutic applications for treating IBD with evidence from animal experiments. | Lee, Hoyul; Jeon, Jae-Han; Kim, Eun Soo | Kyungpook Natl Univ, Res Inst Aging & Metab, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Internal Med, Div Gastroenterol, Daegu, South Korea | Kim, Sang/J-5398-2012 | 58017533900; 36910340400; 57203086704 | dandy813@hanmail.net; | FRONTIERS IN IMMUNOLOGY | FRONT IMMUNOL | 1664-3224 | 14 | SCIE | IMMUNOLOGY | 2023 | 5.7 | 20.2 | 0.74 | 2025-06-25 | 11 | 12 | mitochondria; IBD - inflammatory bowel disease; immunometabolism; T cell; treatment; inflammation | OPERATED CA2+ ENTRY; METABOLIC CHECKPOINT; PYRUVATE-DEHYDROGENASE; ENDOPLASMIC-RETICULUM; TRANSCRIPTION FACTOR; EXPERIMENTAL COLITIS; AEROBIC GLYCOLYSIS; CROHNS-DISEASE; IN-VIVO; DIFFERENTIATION | IBD - inflammatory bowel disease; immunometabolism; inflammation; mitochondria; T cell; treatment | Animals; Glycolysis; Inflammation; Inflammatory Bowel Diseases; Mitochondria; T-Lymphocytes; arctigenin; C reactive protein; calcineurin; carbonyl cyanide chlorophenylhydrazone; carnitine; CD28 antigen; CD3 antigen; CD4 antigen; deoxycorticosterone acetate; dichloroacetic acid; gamma interferon; glucose transporter; glucose transporter 1; glutaminase; glutamine; hexokinase; immunosuppressive agent; interleukin 17; interleukin 2; lactate dehydrogenase; lactic acid; messenger RNA; metformin; mitochondrial DNA; Myc protein; nonsteroid antiinflammatory agent; pyruvate dehydrogenase kinase 4; pyruvate dehydrogenase phosphatase; pyruvate oxidase; ritonavir; sirolimus; trinitrobenzenesulfonic acid; aerobic glycolysis; AMPK signaling; anaerobic glycolysis; autoimmune disease; autophagy (cellular); calcium homeostasis; cell death; cell dysfunction; cytokine production; dendritic cell; enzyme active site; eosinophil; epithelium lesion; erythrocyte sedimentation rate; glucose metabolism; glycolysis; hematopoietic stem cell; human; hyperglycemia; immune response; immunometabolism; inflammation; inflammatory bowel disease; lymphocytic infiltration; macrophage; mesentery lymph node; mitochondrial biogenesis; mitochondrion; monocyte count; multiple sclerosis; neutrophil; osteoporosis; oxygen consumption; pentose phosphate cycle; peripheral blood mononuclear cell; peritoneum cell; psoriasis; regulatory T lymphocyte; Review; rheumatoid arthritis; splenic T cell; systemic lupus erythematosus; T lymphocyte; Th17 cell; transcription coupled repair; tuberous sclerosis; von Hippel Lindau disease; animal; metabolism; mitochondrion | English | 2023 | 2023-09-22 | 10.3389/fimmu.2023.1219422 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Pediatric humoral immune responses and infection risk after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and two-dose vaccination during SARS-CoV-2 omicron BA.5 and BN.1 variants predominance in South Korea | Background: Humoral immune responses and infection risk after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) vaccination during the Omicron BA.5 and BN.1 variants predominant period remains unexplored in pediatric population.Methods: We examined anti-spike (anti-S) immunoglobulin G (IgG) responses in a total of 986 children aged 4-18 years who visited outpatient clinics between June 2022 and January 2023, with a history of SARS-CoV-2 infection alone, completed two doses of COVID-19 vaccination alone, vaccine-breakthrough infection (i.e., infection after the single dose of vaccination), and no antigenic exposure. Furthermore, to determine SARS-CoV-2 infection risk, the incidence of newly developed SARS-CoV-2 infection was investigated up to March 2023.Results: The anti-S IgG levels in the 'vaccine-breakthrough infection' group exceeded those in the 'infection alone' and 'vaccination alone' groups (both P <0.01). Furthermore, the 'vaccination alone' group experienced more rapid anti-S IgG waning than the 'infection alone' and 'vaccine-breakthrough infection' groups (both P <0.01). We could not identify newly developed SARS-CoV-2 infection in the 'vaccine-breakthrough infection' group.Conclusion: Our findings suggest that hybrid immunity, acquired from SARS-CoV-2 infection and COVID-19 vaccination, was a potentially higher and longer-lasting humoral immune response and protected against SARS-CoV-2 infection in pediatric population during Omicron BA.5 and BN.1 variants predominant. | Choi, Hyun-Woo; Achangwa, Chiara; Park, Joonhong; Lee, Sun Min; Lee, Nan Young; Jeon, Chae-Hyeon; Choi, Jeong-Hwa; Do, Hyun Kyung; Nam, Jeong-Hyun; Lee, June-Woo; Kim, Byoungguk; Ryu, Sukhyun; Kee, Seung-Jung | Chonnam Natl Univ Hosp, Dept Lab Med, Gwangju, South Korea; Konyang Univ, Coll Med, Dept Prevent Med, Daejeon, South Korea; Jeonbuk Natl Univ, Dept Lab Med, Med Sch & Hosp, Jeonju, South Korea; Pusan Natl Univ, Sch Med, Dept Lab Med, Pusan, South Korea; Kyungpook Natl Univ, Sch Med, Dept Clin Pathol, Daegu, South Korea; Chonnam Natl Univ, Med Sch, Res Inst Med Sci, BioMed Sci Grad Program BMSGP, Hwasun, South Korea; Korea Dis Control & Prevent Agcy, Natl Inst Infect Dis, Ctr Vaccine Res, Div Vaccine Clin Res,Natl Inst Hlth, Cheongju, South Korea; Chonnam Natl Univ, Med Sch, Dept Lab Med, Gwangju, South Korea | ; Park, Joonhong/AAZ-9885-2020; Lee, Sun Min/R-7717-2019; Ryu, Sukhyun/L-2706-2019 | 55724369200; 57225063173; 37665651200; 56079176600; 57209204358; 57643453000; 58790155200; 58563603300; 54795525100; 56537158800; 57792610600; 57203497905; 14041984100 | gentryu@onehealth.or.kr;sjkee1968@naver.com; | FRONTIERS IN IMMUNOLOGY | FRONT IMMUNOL | 1664-3224 | 14 | SCIE | IMMUNOLOGY | 2023 | 5.7 | 20.2 | 0.58 | 2025-06-25 | 4 | 4 | hybrid immunity; SARS-CoV-2; COVID-19; antibody response; child; vaccine | ANTIBODIES; SEROPREVALENCE | antibody response; child; COVID-19; hybrid immunity; SARS-CoV-2; vaccine | Breakthrough Infections; Child; COVID-19; COVID-19 Vaccines; Humans; Immunity, Humoral; Immunoglobulin G; Republic of Korea; SARS-CoV-2; Vaccination; bnt161b2; immunoglobulin G; nucleocapsid protein; RNA vaccine; SARS-CoV-2 antibody; tozinameran; SARS-CoV-2 vaccine; adult; Article; breakthrough infection; cardiovascular disease; child; comparative study; coronavirus disease 2019; endocrine disease; female; follow up; health survey; human; humoral immunity; immune response; immunoassay; incidence; infection risk; limit of quantitation; major clinical study; male; malignant neoplasm; SARS-CoV-2 (lineage BA.5); school child; sensitivity and specificity; South Korea; temporal analysis; vaccination; coronavirus disease 2019; humoral immunity; Severe acute respiratory syndrome coronavirus 2; vaccination | English | 2023 | 2023-12-20 | 10.3389/fimmu.2023.1306604 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Single cell transcriptome analyses reveal the roles of B cells in fructose-induced hypertension | Rationale: While the immune system plays a crucial role in the development of hypertension, the specific contributions of distinct immune cell populations remain incompletely understood. The emergence of single-cell RNA-sequencing (scRNA-seq) technology enables us to analyze the transcriptomes of individual immune cells and to assess the significance of each immune cell type in hypertension development. Objective: We aimed to investigate the hypothesis that B cells play a crucial role in the development of fructose-induced hypertension. Methods and Results: Eight-week-old Dahl salt-sensitive (SS) male rats were divided into two groups and given either tap water (TW) or a 20% fructose solution (HFS) for 4 weeks. Systolic blood pressure was measured using the tail-cuff method. ScRNA-seq analysis was performed on lamina propria cells (LPs) and peripheral blood mononuclear cells (PBMCs) obtained from SS rats subjected to either TW or HFS. The HFS treatment induced hypertension in the SS rats. The analysis revealed 27 clusters in LPs and 28 clusters in PBMCs, allowing for the identification and characterization of various immune cell types within each cluster. Specifically, B cells and follicular helper T (Tfh) cells were prominent in LPs, while B cells and M1 macrophages dominated PBMCs in the HFS group. Moreover, the HFS treatment triggered an increase in the number of B cells in both LPs and PBMCs, accompanied by activation of the interferon pathway. Conclusions: The significant involvement of B cells in intestinal and PBMC responses indicates their pivotal contribution to the development of hypertension. This finding suggests that targeting B cells could be a potential strategy to mitigate high blood pressure in fructose-induced hypertension. Moreover, the simultaneous increase in follicular B cells and Tfh cells in LPs, along with the upregulation of interferon pathway genes in B cells, underscores a potential autoimmune factor contributing to the pathogenesis of fructose-induced hypertension in the intestine. | Kim, Cheong-Wun; Joo, Sung Yong; Kim, Boa; Kim, Jee Young; Jang, Sungmin; Tzeng, Shiang-Jong; Lee, Sang Jin; Kim, Myunghoo; Kim, Inkyeom | Kyungpook Natl Univ, Kyungpook Natl Univ KNU Biomed Convergence Program, Cardiovasc Res Inst,Dept Pharm, Sch Med,BK21 Plus, Daegu, South Korea; Pusan Natl Univ, Dept Anim Sci, Miryang, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Sch Med, Daegu, South Korea; Natl Taiwan Univ, Grad Inst Pharmacol, Coll Med, Taipei, Taiwan; Kyungpook Natl Univ, Cardiovasc Res Inst, Sch Med, Div Rheumatol, Daegu, South Korea | Tzeng, Shiang-Jong/AED-3885-2022 | 56662531400; 57995629100; 58746260500; 57222261625; 57897824500; 8061289500; 57192516055; 36611749600; 7404144630 | sjtzeng@ntu.edu.tw;dream1331@knu.ac.kr;kimmhmm3@gmail.com;inkim@knu.ac.kr; | FRONTIERS IN IMMUNOLOGY | FRONT IMMUNOL | 1664-3224 | 14 | SCIE | IMMUNOLOGY | 2023 | 5.7 | 20.2 | 0.58 | 2025-06-25 | 4 | 4 | single-cell RNA-sequencing; immunity; hypertension; B cell; interferon pathway | REGULATORY T-CELLS; I-INTERFERON; ANTIGEN PRESENTATION; CUTTING EDGE; SUPPRESSION; MICROBIOME; MECHANISMS; NAIVE; IL-21 | B cell; hypertension; immunity; interferon pathway; single-cell RNA-sequencing | Animals; Hypertension; Interferons; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Rats; Rats, Inbred Dahl; Single-Cell Gene Expression Analysis; CD3 antigen; CD68 antigen; CD8 antigen; fructose; lipopolysaccharide; pentobarbital; protein tyrosine phosphatase; receptor type tyrosine protein phosphatase C; transcriptome; interferon; lipopolysaccharide; animal experiment; animal model; Article; B lymphocyte; blood pressure; cell isolation; controlled study; cytotoxic T lymphocyte; gene expression; gene set enrichment analysis; hypertension; male; nonhuman; peripheral blood mononuclear cell; principal component analysis; protein isolation; rat; Rattus norvegicus; single cell analysis; single cell RNA seq; systolic blood pressure; Th17 cell; transcriptome sequencing; animal; Dahl rat; genetics; metabolism; mononuclear cell; single-cell gene expression analysis | English | 2023 | 2023-11-17 | 10.3389/fimmu.2023.1279439 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | The emerging role of exosomes in innate immunity, diagnosis and therapy | Exosomes, which are nano-sized transport bio-vehicles, play a pivotal role in maintaining homeostasis by exchanging genetic or metabolic information between different cells. Exosomes can also play a vital role in transferring virulent factors between the host and parasite, thereby regulating host gene expression and the immune interphase. The association of inflammation with disease development and the potential of exosomes to enhance or mitigate inflammatory pathways support the notion that exosomes have the potential to alter the course of a disease. Clinical trials exploring the role of exosomes in cancer, osteoporosis, and renal, neurological, and pulmonary disorders are currently underway. Notably, the information available on the signatory efficacy of exosomes in immune-related disorders remains elusive and sporadic. In this review, we discuss immune cell-derived exosomes and their application in immunotherapy, including those against autoimmune connective tissue diseases. Further, we have elucidated our views on the major issues in immune-related pathophysiological processes. Therefore, the information presented in this review highlights the role of exosomes as promising strategies and clinical tools for immune regulation. | Gangadaran, Prakash; Madhyastha, Harishkumar; Madhyastha, Radha; Rajendran, Ramya Lakshmi; Nakajima, Yuichi; Watanabe, Nozomi; Velikkakath, Anoop Kumar G.; Hong, Chae Moon; Gopi, Rahul Velikkakath; Muthukalianan, Gothandam Kodiveri; Valsala Gopalakrishnan, Abilash; Jeyaraman, Madhan; Ahn, Byeong-Cheol | Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, FOUR KNU Convergence Educ Program Biomed Sci Creat, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Nucl Med, Daegu, South Korea; Univ Miyazaki, Fac Med, Dept Cardiovasc Physiol, Miyazaki, Japan; Yenepoya Deemed Univ, Ctr Syst Biol & Mol Med, Yenepoya Res Ctr, Mangalore, Karnataka, India; Sree Chitra Thirunal Inst Med Sci & Technol, Dept Tissue Engn & Regenerat Technol, Thiruvananthapuram, India; Vellore Inst Technol VIT, Dept Biomed Sci, Vellore, India; Sri Lalithambigai Med Coll & Hosp, Dr MGR Educ & Res Inst, Fac Med, Chennai, Tamil Nadu, India; Dr MGR Educ & Res Inst Univ, ACS Hosp, Dept Orthopaed, Chennai, Tamil Nadu, India | Madhyastha, Harishkumar/K-8343-2019; Kodiveri Muthukaliannan, Gothandam/C-5734-2014; Rajendran, Ramya/AAV-6338-2021; Gangadaran, Prakash/AAV-3102-2021; G, Abilash/C-1482-2019; Jeyaraman, Madhan/ABB-8464-2020 | 54393130400; 24376508900; 26431035000; 57195318729; 23767646900; 7403345507; 55062430100; 37050876700; 58085005700; 8686538600; 57199322878; 57216926503; 7202791511 | hkumar@med.miyazaki-u.ac.jp;abc2000@knu.ac.kr; | FRONTIERS IN IMMUNOLOGY | FRONT IMMUNOL | 1664-3224 | 13 | SCIE | IMMUNOLOGY | 2023 | 5.7 | 20.2 | 2.9 | 2025-06-25 | 48 | 49 | exosomes; secretory cells; tissue inflammation; circulation; therapy | POLYCYSTIC-OVARY-SYNDROME; MILK-DERIVED EXOSOMES; TOLL-LIKE RECEPTORS; REGULATORY T-CELLS; HIV TYPE-1 NEF; EXTRACELLULAR VESICLES; STEM-CELLS; PROTEOMIC ANALYSIS; DENDRITIC CELLS; INFECTED-CELLS | circulation; exosomes; secretory cells; therapy; tissue inflammation | Autoimmune Diseases; Exosomes; Humans; Immunity, Innate; Inflammation; Neoplasms; ADAM10 endopeptidase; angiotensin converting enzyme 2; apolipoprotein B; autophagy related protein; copper 64; glucose transporter 1; hypoxia inducible factor 1; immunoglobulin enhancer binding protein; interleukin 10; interleukin 1beta; interleukin 4; interleukin 7; long untranslated RNA; major histocompatibility antigen class 1; major histocompatibility antigen class 2; microRNA 29; synaptosome associated protein 23; syntaxin; toll like receptor 4; toll like receptor 8; transforming growth factor beta; tumor necrosis factor; unclassified drug; virulence factor; virus spike protein; arthritis; asthma; autoimmunity; bacterial infection; clinical trial (topic); coronavirus disease 2019; Cryptosporidium; exocytosis; exosome; homeostasis; human; immune response; immunocompetent cell; immunological tolerance; immunoregulation; immunotherapy; inflammation; innate immunity; insulin dependent diabetes mellitus; kidney disease; Leishmania; lung disease; neurologic disease; nonhuman; osteoporosis; pathophysiology; positron emission tomography; protozoal infection; psoriasis; Review; serodiagnosis; Th1 cell; Th17 cell; Trypanosoma cruzi; autoimmune disease; metabolism; neoplasm | English | 2023 | 2023-01-16 | 10.3389/fimmu.2022.1085057 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Zr-Modified Ni/CaO Dual Function Materials (DFMs) for Direct Methanation in an Integrated CO2 Capture and Utilization Process | An integrated CO2 capture and direct methanation (ICCM) system has recently gained significant attention as a promising process to produce value-added chemicals. Compared to conventional CO2 capture and utilization, ICCM is a simplified process that directly converts captured CO2 without purification at lower thermal inputs. One of the primary limitations is the deactivation of the sorbent and the embedded catalysts after several thermal cycles. In this study, we formulated thermally stable macroporous structured Ni/CaO dual function materials (DFMs) by incorporating a Zr stabilizer. The textural properties, porosity, CO2 capture performance, and catalytic activity of Zr-modified Ni/CaO (Ni/CaZr) were assessed. In situ DRIFTS was used to investigate the possible intermediates and reactions during the ICCM. It was found that CH4 is produced from the formate and methoxy intermediates route on the CaO surface and the CO intermediate route on the Ni surface. Ni/CaZr had improved thermal stability with the best CO2 capture capacity (13-14 mmol of CO2/g), CH4 productivity (13-14 mmol of CH4/g), CO2 sorption, and desorption kinetics at 500 degrees C. The benefit of adding Zr for ICCM enhanced the macroporous structures, which enhanced the CO2 mass transport and prevented the sintering of Ni and CaO. | Jo, Seongbin; Woo, Jin Hyeok; Nguyen, Tu; Kim, Ju Eon; Kim, Tae Young; Ryu, Ho-Jung; Hwang, Byungwook; Kim, Jae Chang; Lee, Soo Chool; Gilliard-AbdulAziz, Kandis Leslie | Univ Calif Riverside, Dept Chem & Environm Engn, Riverside, CA 92521 USA; Kyungpook Natl Univ, Dept Chem Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Adv Energy Technol, Daegu 41566, South Korea; Korea Inst Energy Res, Daejeon 34129, South Korea; Univ Southern Calif, Sonny Astani Dept Civil & Environm Engn, Los Angeles, CA 90089 USA | Kim, Yu/L-8480-2017; Jo, SeongBin/MFJ-9000-2025; Ryu, Ho-Jung/AAV-3451-2020 | 57190754848; 57215492471; 57223155984; 58417827600; 57208461628; 7202277238; 44461423600; 55382762400; 8524020100; 57200598917 | kjchang@knu.ac.kr;soochool@knu.ac.kr;klabdulaziz@engr.ucr.edu; | ENERGY & FUELS | ENERG FUEL | 0887-0624 | 1520-5029 | 37 | 24 | SCIE | ENERGY & FUELS;ENGINEERING, CHEMICAL | 2023 | 5.2 | 20.3 | 1.6 | 2025-06-25 | 15 | 15 | CAO-BASED SORBENTS; IN-SITU DRIFTS; CALCIUM-OXIDE; NI CATALYSTS; STABILITY; AL | Catalyst activity; Hydrogenation; Methanation; Nickel; Reaction intermediates; Sintering; Thermodynamic stability; Zirconium; CH 4; Dual function; Function material; Macroporous; Stabiliser; Thermal; Thermal inputs; Thermally stable; Value-added chemicals; ]+ catalyst; Carbon dioxide | English | 2023 | 2023-12-07 | 10.1021/acs.energyfuels.3c02935 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | A Plant-Produced Porcine Parvovirus 1-82 VP2 Subunit Vaccine Protects Pregnant Sows against Challenge with a Genetically Heterologous PPV1 Strain | Porcine parvovirus (PPV) causes reproductive failure in sows, and vaccination remains the most effective means of preventing infection. The NADL-2 strain has been used as a vaccine for similar to 50 years; however, it does not protect animals against genetically heterologous PPV strains. Thus, new effective and safe vaccines are needed. In this study, we aimed to identify novel PPV1 strains, and to develop PPV1 subunit vaccines. We isolated and sequenced PPV1 VP2 genes from 926 pigs and identified ten PPV1 strains (belonging to Groups C, D and E). We selected the Group D PPV1-82 strain as a vaccine candidate because it was close to the highly pathogenic 27a strain. The PPV1-82 VP2 protein was produced in Nicotiana benthamiana. It formed virus-like particles and exhibited a 2(11) agglutination value. The PPV1-190313 strain (Group E), isolated from an aborted fetus, was used as the challenging strain because it was pathogenic. The unvaccinated sow miscarried at 8 days postchallenge, and mummified fetuses were all PPV1-positive. By contrast, pregnant sows vaccinated with PPV1-82 VP2 had 9-11 Log(2) antibody titers and produced normal fetuses after PPV1-190313 challenge. These results suggest the PPV1-82 VP2 subunit vaccine protects pregnant sows against a genetically heterologous PPV1 strain by inducing neutralizing antibodies. | Cho, Kyou-Nam; Ouh, In-Ohk; Park, Young-Min; Park, Min-Hee; Min, Kyung-Min; Kang, Hyang-Ju; Yun, Su-Yeong; Song, Jae-Young; Hyun, Bang-Hun; Park, Choi-Kyu; Choi, Bo-Hwa; Lee, Yoon-Hee | BioApplications Inc, Pohang Si 37668, Gyeongsangbug D, South Korea; Anim & Plant Quarantine Agcy, Viral Dis Div, Gimcheon Si 39660, Gyeongsangbug D, South Korea; BioPOA, Hwaseong Si 18469, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu Si 41566, Gyeongsang Do, South Korea; Korea Dis Control & Prevent Agcy, Cheongju 28160, Chungcheongbug, South Korea | Park, Youngmin/AAG-3289-2021; LEE, SEJUE/KMX-1267-2024 | 58077791300; 56096229500; 55982602900; 57203168021; 57203167062; 14054152200; 58076956500; 7404788090; 7006836849; 24768064900; 57224205080; 16175478000 | bhchoi@bioapp.co.kr;lyhee74@korea.kr; | VACCINES | VACCINES-BASEL | 2076-393X | 11 | 1 | SCIE | IMMUNOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2023 | 5.2 | 20.4 | 0.19 | 2025-06-25 | 2 | 1 | porcine parvovirus 1; plant-produced subunit vaccine; virus-like particle; viral protein 2; cross reactivation | VIRUS; DISEASE; PATHOGENESIS; INFECTION; EVOLUTION | cross reactivation; plant-produced subunit vaccine; porcine parvovirus 1; viral protein 2; virus-like particle | kanamycin; rifampicin; subunit vaccine; Agrobacterium tumefaciens; antibody titer; Article; bacterial strain; cell agglutination; cesarean section; DNA extraction; DNA sequencing; electroporation; enzyme linked immunosorbent assay; Escherichia coli; gene sequence; hemagglutination; hemagglutination inhibition; histology; immunogenicity; Nicotiana benthamiana; nucleotide sequence; phylogeny; Porcine parvovirus; transmission electron microscopy; vaccination; virus strain | English | 2023 | 2023-01 | 10.3390/vaccines11010054 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Adverse Reactions after BNT162b2 Messenger RNA Vaccination for Coronavirus Disease 2019 in Healthcare Workers Compared with Influenza Vaccination | This study aimed to compare adverse reactions following BNT162b2 and influenza vaccinations in healthcare workers. This study included healthcare workers who received the BNT162b2 vaccine and/or inactivated influenza vaccine, quadrivalent (IIV4), on 18-29 October 2021 at a tertiary hospital in Korea. IIV4 was administered and BNT162b2 was subsequently administered one week later. The participants responded to a mobile questionnaire regarding adverse events. The overall adverse reaction rates were 90.6% in the BNT162b2 + IIV4 group, 90.4% in the BNT162b2 alone group, and 44.1% in the IIV4 alone group (p < 0.001). Fever occurred in 19.5%, 26.9%, and 3.3% of participants in the BNT162b2 + IIV4, BNT162b2 alone, and IIV4 alone groups, respectively (p < 0.001). The most common local and systemic adverse reactions were injection site pain (65.0%) and fatigue (58.6%), respectively. Injection-site pain was experienced by 88.7%, 88.5%, and 37.5% of the BNT162b2 + IIV4, BNT162b2 alone, and IIV4 alone groups, respectively (p < 0.001). Fatigue was experienced by 74.8%, 78.8%, and 38.6% of the BNT162b2 + IIV4, BNT162b2 alone, and IIV4 alone groups, respectively (p < 0.001). Adverse reactions occurred at a significantly higher frequency after BNT162b2 than after IIV4. The frequency of adverse reactions one week after vaccination with IIV4 and BNT162b2 was not different from that after vaccination with BNT162b2 alone. Therefore, coadministration of influenza vaccine with BNT162b2 can be expected to be safe. | Kim, A-Sol; Kim, Sung-Min; Song, Ji-Eun; Hwang, Soyoon; Nam, Eunkyung; Kwon, Ki Tae | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Family Med, Daegu 41404, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med,Div Infect Dis, Daegu 41404, South Korea | Song, Jieun/LLM-7026-2024; Kim, Hanjin/KYP-2633-2024; Nam, Eunkyung/HKM-7271-2023; Hwang, Soyoon/HHM-5762-2022 | 57203290656; 57216656403; 57217295366; 57203160675; 58121908200; 9733850500 | ktkwon@knu.ac.kr; | VACCINES | VACCINES-BASEL | 2076-393X | 11 | 2 | SCIE | IMMUNOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2023 | 5.2 | 20.4 | 0.58 | 2025-06-25 | 4 | 3 | SARS-CoV-2; health personnel; immunization; injection site reaction; fatigue | VACCINES | fatigue; health personnel; immunization; injection site reaction; SARS-CoV-2 | influenza vaccine; tfinj; tozinameran; abdominal pain; adult; anxiety; arthralgia; Article; autoimmune disease; chill; chronic respiratory tract disease; coronavirus disease 2019; depression; diabetes mellitus; diarrhea; disease severity; dizziness; edema; fatigue; female; fever; headache; health care personnel; heart disease; hospitalization; human; hypertension; immunization; influenza vaccination; injection site pain; major clinical study; male; middle aged; myalgia; nausea and vomiting; questionnaire; risk factor; skin redness; swelling; thorax pain | English | 2023 | 2023-02 | 10.3390/vaccines11020363 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Heterologous Prime-Boost Vaccination with Commercial FMD Vaccines Elicits a Broader Immune Response than Homologous Prime-Boost Vaccination in Pigs | Three commercial vaccines are administered in domestic livestock farms for routine vaccination to aid for foot-and-mouth disease (FMD) control in Korea. Each vaccine contains distinct combinations of inactivated serotype O and A FMD virus (FMDV) antigens: O/Manisa + O/3039 + A/Iraq formulated in a double oil emulsion (DOE), O/Primorsky + A/Zabaikalsky formulated in a DOE, and O/Campos + A/Cruzeiro + A/2001 formulated in a single oil emulsion. Despite the recommendation for a prime-boost vaccination with the same vaccine in fattening pigs, occasional cross-inoculation is inevitable for many reasons, such as lack of compliance with vaccination guidelines, erroneous application, or change in vaccine types by suppliers. Therefore, there have been concerns that a poor immune response could be induced by cross-inoculation due to a failure to boost the immune response. In the present study, it was demonstrated by virus neutralization and ELISA tests that cross-inoculation of pigs with three commercial FMD vaccines does not hamper the immune response against the primary vaccine strains and enhances broader cross-reactivity against heterologous vaccine antigens whether they were applied or not. Therefore, it could be concluded that the cross-inoculation of FMD vaccines can be used as a regimen to strategically overcome the limitation of the antigenic spectrum induced by the original regimen. | Kim, Jaejo; Lee, Seung-Heon; Kim, Ha-Hyun; Park, Jong-Hyeon; Park, Choi-Kyu | Anim & Plant Quarantine Agcy, 177 Hyeoksin 8 ro, Gimcheon City 39660, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Anim Dis Intervent Ctr, Daegu 41566, South Korea | 36067760200; 57061932300; 12805065700; 55717103700; 24768064900 | parkjhvet@korea.kr;parkck@knu.ac.kr; | VACCINES | VACCINES-BASEL | 2076-393X | 11 | 3 | SCIE | IMMUNOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2023 | 5.2 | 20.4 | 0.58 | 2025-06-25 | 3 | 3 | foot-and-mouth disease virus; cross-inoculation; heterologous prime-boost; homologous prime-boost; serological performance | MOUTH-DISEASE; MOLECULAR EPIDEMIOLOGY; KOREA | cross-inoculation; foot-and-mouth disease virus; heterologous prime-boost; homologous prime-boost; serological performance | vaccine; animal experiment; Article; cross reaction; enzyme linked immunosorbent assay; foot and mouth disease; Foot and mouth disease virus; gene sequence; immune response; immunization; immunogenicity; Korea; nonhuman; phylogenetic tree; phylogeny; serology; serotype; vaccination; virus neutralization | English | 2023 | 2023-03 | 10.3390/vaccines11030551 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Liquid dielectric layer-based microfluidic capacitive sensor for wireless pressure monitoring | Microfluidic capacitive sensors with enhanced performance and wireless sensing capability present great ad-vantages for various pressure sensor applications. In this work, a liquid dielectric layer (LDL)-based wireless capacitive sensor for high sensitivity and low-pressure detection has been demonstrated. The wireless capacitive sensor was designed based on an LC resonant circuit model and integrated into a microfluidic device by intro-ducing liquid-metal Galinstan into polydimethylsiloxane (PDMS) microchannels. The effect of various dielectric mediums (air, deionized (DI) water, and saline) on the performance of the capacitive sensor was characterized to study the sensitivity and robustness of the devices. Moreover, the high permittivity of liquid dielectric mediums enhances the sensitivity of the pressure sensor. The sensitivities of 0.0043 kPa-1, 0.0111 kPa-1, and 0.0125 kPa-1 were achieved for air, DI water, and saline-based dielectric mediums, respectively, for a low-pressure region of 0-10 kPa. Furthermore, we fabricated the wireless pressure sensor in three different form factors to enhance the applicability of the flexible wireless sensor. We also demonstrated the possibility of wirelessly monitoring human motion through real-time pressure detection using capacitive sensors fabricated with a liquid dielectric medium. The proposed LDL-based capacitive sensor, with high sensitivity, could be a potential candidate for low-pressure sensor applications, especially in detecting subtle pressure from the human body. | Munirathinam, Karthikeyan; Kwon, Kyeongha; Park, Jongsung; Lee, Dong-Weon | Chonnam Natl Univ, Sch Mech Engn, MEMS & Nanotechnol Lab, Gwangju 61186, South Korea; Chonnam Natl Univ, Adv Med Device Res Ctr Cardiovasc Dis, Gwangju 61186, South Korea; Chonnam Natl Univ, Ctr Next Generat Sensor Res & Dev, Gwangju 61186, South Korea; Korea Adv Inst Sci & Technol, Sch Elect Engn, Daejeon 305701, South Korea; Kyungpook Natl Univ, Dept Precis Mech Engn, Sangju 37224, South Korea | Kwon, Kyeongha/AAT-8407-2020 | 57219625153; 56109998000; 57189583605; 34875377700 | mems@jnu.ac.kr; | SENSORS AND ACTUATORS A-PHYSICAL | SENSOR ACTUAT A-PHYS | 0924-4247 | 1873-3069 | 357 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION | 2023 | 4.1 | 20.4 | 0.68 | 2025-06-25 | 5 | 5 | Liquid dielectric layer; Parallel plate capacitor; Wireless pressure sensor; Liquid metal; Microfluidic devices; Human motion monitoring | STRAIN SENSORS; SKIN; FILM; SOFT | Human motion monitoring; Liquid dielectric layer; Liquid metal; Microfluidic devices; Parallel plate capacitor; Wireless pressure sensor | Capacitive sensors; Deionized water; Dielectric liquids; Fluidic devices; Microchannels; Microfluidics; Permittivity; Plate metal; Polydimethylsiloxane; Pressure sensors; Printed circuit boards; Resonant circuits; Saline water; Silicones; Dielectric layer; Dielectric medium; Human motion monitoring; Human motions; Liquid dielectric layer; Liquid dielectrics; Low pressures; Microfluidics devices; Parallel plate capacitors; Wireless pressure sensors; Liquid metals | English | 2023 | 2023-08-01 | 10.1016/j.sna.2023.114393 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A case report of mucinous cystadenoma with contralateral serous cystadenofibroma in identical twin | Introduction: There are limited reports on ovarian neoplasm occurring among identical twins. Most previous reports showed ovarian teratoma found in both twins. Herein, we report for the first time a case of ovarian mucinous cystadenoma with contralateral serous cystadenofibroma found in twin siblings. Case report: One patient suffered from abdominal distension and the following computed tomography found ovarian mucinous cystadenoma. During the laparoscopy, another ovarian mass was found in the contralateral ovary. The histopathology revealed ovarian mucinous cystadenoma with contralateral serous cystadenofibroma. The twin sister had no symptoms but underwent gynecological screening. She also showed a similar finding, mucinous cystadenoma with serous cystadenofibroma on the contralateral ovary. Both patients underwent laparoscopic bilateral ovarian cystectomy. Conclusion: This is the first clinical report on left ovarian mucinous cystadenoma with right serous cystadenofibroma in twin siblings. Our cases support awareness of ovarian tumors in twin sisters. | Lee, Jisun; Kim, Yong-Jin; Heo, Yujin; Lee, Hyun Jung | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Obstet & Gynecol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Pathol, Daegu, South Korea | Kim, Yong-Jin/ADJ-6184-2022 | 57216463710; 56150365500; 58107443800; 57202930844 | hyunjunglee@knu.ac.kr; | HELIYON | HELIYON | 2405-8440 | 9 | 5 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.4 | 20.5 | 0.12 | 2025-06-25 | 1 | 1 | Mucinous cystadenoma; Serous cystadenofibroma; Identical twin | FAMILIAL RISK; HERITABILITY; TERATOMA; CANCER; OVARY | Identical twin; Mucinous cystadenoma; Serous cystadenofibroma | English | 2023 | 2023-05 | 10.1016/j.heliyon.2023.e16345 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | An update on stem cell and stem cell-derived extracellular vesicle-based therapy in the management of Alzheimer's disease | Globally, neurological diseases pose a major burden to healthcare professionals in terms of the management and prevention of the disorder. Among neurological diseases, Alzheimer's disease (AD) accounts for 50%-70% of dementia and is the fifth leading cause of mortality worldwide. AD is a progressive, degenerative neurological disease, with the loss of neurons and synapses in the cerebral cortex and subcortical regions. The management of AD remains a debate among physicians as no standard and specific "disease-modifying" modality is available. The concept of 'Regenerative Medicine' is aimed at regenerating the degenerated neural tissues to reverse the pathology in AD. Genetically modified engineered stem cells modify the course of AD after transplantation into the brain. Extracellular vesicles (EVs) are an emerging new approach in cell communication that involves the transfer of cellular materials from parental cells to recipient cells, resulting in changes at the molecular and signaling levels in the recipient cells. EVs are a type of vesicle that can be transported between cells. Many have proposed that EVs produced from mesenchymal stem cells (MSCs) may have therapeutic promise in the treatment of AD. The biology of AD, as well as the potential applications of stem cells and their derived EVs-based therapy, were explored in this paper. | Jeyaraman, Madhan; Rajendran, Ramya Lakshmi; Muthu, Sathish; Jeyaraman, Naveen; Sharma, Shilpa; Jha, Saurabh Kumar; Muthukanagaraj, Purushothaman; Hong, Chae Moon; da Fonseca, Lucas Furtado; Lana, Jose Fabio Santos Duarte; Ahn, Byeong-Cheol; Gangadaran, Prakash | ACS Med Coll & Hosp, Dr MGR Educ & Res Inst, Dept Orthopaed, Chennai 600056, Tamil Nadu, India; Sharda Univ, Sch Engn & Technol, Dept Biotechnol, Greater Noida 201310, Uttar Pradesh, India; Indian Stem Cell Study Grp ISCSG Assoc, Lucknow 226010, Uttar Pradesh, India; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Govt Dindigul Med Coll & Hosp, Dept Orthoped, Dindigul 624001, Tamil Nadu, India; Sri Balaji Vidyapeeth, Shri Sathya Sai Med Coll & Res Inst, Dept Orthoped, Chengalpet 603108, Tamil Nadu, India; All India Inst Med Sci, Dept Paediat Surg, New Delhi 110029, India; SUNY Binghamton, Upstate Binghamton Clin Campus, Dept Internal Med & Psychiat, Binghamton, NY 13904 USA; Univ Fed Sao Paulo, Dept Orthoped, BR-04023062 Sao Paulo, SP, Brazil; Bone & Cartilage Inst, Dept Orthoped, BR-13334170 Indaiatuba, SP, Brazil; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, FOUR KNU Convergence Educ Program Biomed Sci Creat, BK21, Daegu 41944, South Korea; Karpagam Acad Higher Educ, Fac Engn, Dept Biotechnol, Coimbatore 641021, Tamil Nadu, India; Uttaranchal Univ, Sch Appl & LifeSciences SALS, Dept Biotechnol, Dehra Dun 248007, India; Chandigarh Univ, Dept Biotechnol Engn & Food Technol, Mohali 140413, India | Jeyaraman, Madhan/ABB-8464-2020; Muthu, Sathish/G-5756-2018; Jha, Dr. Saurabh/ACC-9874-2022; Sharma, Shilpa/T-6420-2019; Rajendran, Ramya/AAV-6338-2021; Gangadaran, Prakash/AAV-3102-2021 | 57216926503; 57195318729; 57217850874; 57219306833; 55491666000; 56425051500; 57201699644; 37050876700; 57218318209; 57196220509; 7202791511; 54393130400 | abc2000@knu.ac.kr;prakashg@knu.ac.kr; | HELIYON | HELIYON | 2405-8440 | 9 | 7 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.4 | 20.5 | 0.79 | 2025-06-25 | 9 | 15 | Alzheimer 's disease; Cellular therapy; Mesenchymal stem cell; Extracellular vesicles; Clinical trial | ADULT HIPPOCAMPAL NEUROGENESIS; FACTOR GENE-THERAPY; NEURAL STEM; NEURONAL DIFFERENTIATION; TREATMENT STRATEGIES; IMPROVE MEMORY; ANIMAL-MODELS; MOUSE MODEL; IN-VITRO; TRANSPLANTATION | Alzheimer's disease; Cellular therapy; Clinical trial; Extracellular vesicles; Mesenchymal stem cell | English | 2023 | 2023-07 | 10.1016/j.heliyon.2023.e17808 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Analysis of the mechanism and clinical classification of thoracolumbar scoliosis using three-dimensional EOS and surface electromyography | To analyze a thoracolumbar scoliosis group, we analyzed data from the acquired database by groups: the sEMG group (n = 16) and 3D-EOS group (n = 55). The asymmetric hyper/hypo-activation ratio of muscle and LLD (>3 mm) were measured in the sEMG group. In the 3D-EOS group, we recorded the values of parameters including LLD, pelvis rotation, and kyphosis/ lordosis. In the sEMG study, sEMG examinations were conducted individually in patients with idiopathic scoliosis to analyze hyper/hypoactivation of the paraspinal muscle. In the three-dimensional EOS study, the Cobb angle, femoral height difference, and thoracic kyphosis and lumbar lordosis angles were measured using 2D images and 3D reconstructed images.Sixteen patients with thoracolumbar scoliosis were classified into asymmetric hyperactivation (A-Hyper) and asymmetric hypoactivation (A-Hypo) groups. The Cobb angle of the A-Hyper subtype was significantly higher than that of the A-Hypo subtype (22.41 versus 15.2, p = 0.023). Coronal deviation (p = 0.028) and the pelvis rotation angle (p = 0.001) were significantly higher in the LLD (+) subtype than in the LLD (-) subtype. When we classified patients cross-sectionally along with A-Hyper/Hypo and LLD (+/-), A-Hyper elevated the Cobb angle, and LLD (+) was significantly correlated with coronal deviation and pelvis rotation. In the 3D-EOS evaluation, the pelvic height difference (p = 0.043) and coronal deviation (p = 0.001) were significantly higher in the LLD (+) subtype than in the LLD (-) subtype.In conclusions, paraspinal muscular asymmetry and LLD can be strong factors in inducing or progressing thoracolumbar scoliosis. | Lee, Jin-Gyu; Yoon, Soon Young; Kim, Jeonghyun; Lim, Jiwoon; Ryu, Ju Seok | Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Seoul Natl Univ, Coll Med, Seoul, South Korea; Seoul Natl Univ, Dept Rehabil Med, Bundang Hosp, Seongnam Si, South Korea; Seoul Natl Univ, Dept Rehabil Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Rehabil Med, Bundang Hosp, 82 Gumi Ro 173 Beon Gil, Seongnam Si 13620, Gyeonggi Do, South Korea | Ryu, Ju/W-4027-2019 | 58196043800; 58617339600; 57214339386; 57251250900; 7401868702 | jseok337@snu.ac.kr; | HELIYON | HELIYON | 2405-8440 | 9 | 9 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.4 | 20.5 | 0 | 2025-06-25 | 0 | 0 | Scoliosis; Biomechanics; Paraspinal muscles; Leg length inequality; Electromyography; 3D reconstruction; 3D-EOS; Surface electromyography | ADULT SPINAL DEFORMITY; IDIOPATHIC SCOLIOSIS; PATHOGENESIS | 3D reconstruction; 3D-EOS; Biomechanics; Electromyography; Leg length inequality; Paraspinal muscles; Scoliosis; Surface electromyography | English | 2023 | 2023-09 | 10.1016/j.heliyon.2023.e19510 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Changes in the metabolome of probiotics during the stationary phase increase resistance to lyophilization | In the probiotics manufacturing process, lyophilization damages the cell membrane of microorganisms, reducing their viability and delaying reactivation of their cellular metabolism. The growth phase of microorganisms at the time of lyophilization is thought to significantly affect their viability during storage and reactivation in the in-testine. However, no study has systematically investigated the differences in overcoming mechanisms in mi-croorganisms harvested at different growth phases against lyophilization. Therefore, in this study, we comparatively assessed the resistance mechanism of Bifidobacterium animalis ssp. lactis and Lacticaseibacillus rhamnosus harvested at exponential and stationary growth phases. We found that B. animalis ssp. lactis and L. rhamnosus harvested at the stationary phase had shorter lag phase in growth and higher survival rates during storage than those harvested at the exponential phase. As a result of metabolome analysis, the cells harvested at the stationary phase accumulated trehalose and arabinose, which function as cryoprotectants and protect cells from lyophilization-induced damage. These findings could provide a basis for establishing a manufacturing protocol for lyophilized probiotics that can be rapidly reactivated in the intestine to achieve optimal metabolic activity and induce health benefits. | Jeon, Hyeon Ji; Kim, Jungyeon; Seok, Woo Yeon; Kim, Gwang-Seob; Choi, Boyoung; Shin, Minhye; Lee, Ju-Hoon; Kim, Younghoon; Yang, Jungwoo; Jung, Young Hoon | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Univ Illinois, Carl R Woese Inst Genom Biol, Urbana, IL 61801 USA; Ildong Biosci, Pyeongtaek Si 17957, Gyeonggi Do, South Korea; Inha Univ, Coll Med, Dept Microbiol, Incheon 22212, South Korea; Seoul Natl Univ, Res Inst Agr & Life Sci, Dept Food & Anim Biotechnol, Seoul 08826, South Korea; Seoul Natl Univ, Res Inst Agr & Life Sci, Dept Agr Biotechnol, Seoul 08826, South Korea | Kim, Tae-You/J-2750-2012; Jeon, Hyeon Ji/HPH-4892-2023; Jung, Young/F-1703-2013; Jung, Young Hoon/F-1703-2013; Lee, Ju-Hoon/AAK-7256-2020; Kim, Jinkwon/AAR-6729-2021 | 57795638700; 57214338692; 58130944200; 57225053759; 57226773629; 57208401604; 54975259000; 57861979600; 56076383700; 55550063700 | hhyyeeoonnji@gmail.com;kim131812@kribb.re.kr;swooy70@ildong.com;gskim3139@ildong.com;benmartin@ildong.com;mhshin@inha.ac.kr;juhlee@snu.ac.kr;yjw@ildong.com;younghoonjung@knu.ac.kr; | FOOD BIOSCIENCE | FOOD BIOSCI | 2212-4292 | 2212-4306 | 53 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2023 | 4.8 | 20.5 | 0.8 | 2025-06-25 | 6 | 6 | Probiotics; Lyophilization; Shelf stability; Metabolomics; Stress-response molecule | LACTIC-ACID BACTERIA; SACCHAROMYCES-BOULARDII; TREHALOSE; STRESS; STORAGE; GROWTH; CRYOPROTECTANT; BULGARICUS; STABILITY; VIABILITY | Lyophilization; Metabolomics; Probiotics; Shelf stability; Stress-response molecule | English | 2023 | 2023-06 | 10.1016/j.fbio.2023.102499 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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