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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Review | COVID-19 Outbreak in Daegu City, Korea and Response to COVID-19: How Have We Dealt and What Are the Lessons? | The first coronavirus disease 2019 (COVID-19) outbreak in Daegu city was overcome by efforts, including; 1) prompt isolation and quarantine action by local government with cooperative help from expert groups and the central government, 2) high-intensity social distancing and active cooperation of citizens, 3) admission of asymptomatic and mild patients in `residential treatment centers', and 4) use of a telephone scoring system for the allocation of patients, with a mortality rate of 2.5%. A continuous suppression policy with test, tracing, and treatment (3 Ts) was implemented as an active response to the initial outbreaks in Korea. With the introduction of vaccines and therapeutic agents, the COVID-19 crisis had improved. Recently, the omicron variant was responsible for most domestic outbreaks, albeit with a low mortality rate (0.1%). Since the omicron outbreak, a damage mitigation policy has been implemented, focusing on protecting vulnerable groups. In the future, preparation including below are needed; 1) improving the national public health emergency response system, 2) strengthening the crisis response capacity of local governments, 3) cooperation between public healthcare and private healthcare, and 4) establishing a resilient medical response system. | Kim, Shin-Woo | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med,Div Infect Dis, Daegu, South Korea | Kim, Sun/G-3451-2013 | 57189703358 | ksw2kms@knu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 37 | 50 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 4.5 | 28.1 | 2.07 | 2025-06-25 | 14 | 13 | FOLLOW-UP; GUIDELINES | Covid-19; Daegu city; Korea; Lessons; Outbreak; Preparedness; Response to covid-19 | COVID-19; Disease Outbreaks; Humans; Republic of Korea; SARS-CoV-2; epidemic; epidemiology; human; South Korea | English | 2022 | 2022-12-26 | 10.3346/jkms.2022.37.e356 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | COX-2 Inhibitor Use as an Early Treatment Option for Knee Osteoarthritis Patients in Korea: A Population-Based Cross-Sectional Study | Background: To investigate the use of cyclooxygenase-2 (COX-2) inhibitors as an initial drug treatment for knee osteoarthritis (OA) patients. Methods: From 2013 to 2015, patients with knee OA were identified from the Korean nationwide claims database. Among them, we extracted incident cases of knee OA to identify the initial drug treatment. Trends in the use of non-steroid anti-inflammatory drugs (NSAIDs) including COX-2 inhibitors were analyzed during the first year after their diagnosis. Associated factors for COX-2 inhibitor use were examined using a multivariate logistic regression model. Results: We identified 2,857,999 incident knee OA patients (955,259 in 2013, 981,314 in 2014, and 921,426 in 2015). The mean ?? standard deviation age of patients was 64.2 ?? 9.8 years. The frequency of COX-2 inhibitor use as initial treatment increased from 3.5% in 2013 to 7.2% in 2015 (P < 0.01). In patients taking the medication regularly for one year after diagnosis (medication possession ratio ??? 50%), COX-2 inhibitor use also rapidly increased from 5.5% in 2013 to 11.1% in 2015 (P < 0.01). However, the frequencies of non-selective NSAID and analgesic use did not decrease remarkably. Factors associated with patients using COX-2 inhibitors on initial drug treatment were older age (odds ratio [OR], 1.08), female (OR, 1.24), and comorbidity (OR, 1.03). Type of institution, physician speciality, and insurance type of patients were also associated. Conclusion: In Korea, COX-2 inhibitors have rapidly increased as an initial treatment for knee OA patients, but it has not appeared to reduce the use of non-selective NSAIDs and analgesics. | Cho, Soo-Kyung; Choi, Seongmi; Kim, Hyoungyoung; Song, Yeo-Jin; Jung, Sun-Young; Jang, Eun Jin; Sung, Yoon-Kyoung | Hanyang Univ, Dept Rheumatol, Hosp Rheumat Dis, 222-1 Wangsimni Ro, Seoul 04763, South Korea; Hanyang Univ, Inst Rheumatol Res, Seoul, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Chung Ang Univ, Coll Pharm, Seoul, South Korea; Andong Natl Univ, Dept Informat Stat, 1375 Gyeongdong Ro, Andong 36729, South Korea | ; Song, Young Goo/AGV-5104-2022 | 35185890800; 57211676692; 57202108695; 57221374749; 57207445502; 37861741600; 15754508900 | jejstat@gmail.com;sungyk@hanyang.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 37 | 18 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 4.5 | 28.1 | 0.8 | 2025-06-25 | 5 | 5 | Osteoarthritis; Knee; Medical Management; COX Inhibitor; Nonsteroidal Anti-inflammatory Drugs | NONSTEROIDAL ANTIINFLAMMATORY DRUGS; MANAGEMENT; ADHERENCE; SAFETY; PAIN | Cox inhibitor; Knee; Medical management; Nonsteroidal anti-inflammatory drugs; Osteoarthritis | Aged; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cross-Sectional Studies; Cyclooxygenase 2 Inhibitors; Female; Humans; Middle Aged; Osteoarthritis, Knee; Republic of Korea; analgesic agent; cyclooxygenase 2 inhibitor; nonsteroid antiinflammatory agent; aged; cross-sectional study; female; human; knee osteoarthritis; middle aged; South Korea | English | 2022 | 2022-05-09 | 10.3346/jkms.2022.37.e148 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Epidemiological Trends of Pediatric Inflammatory Bowel Disease in Korea: A Multicenter Study of the Last 3 Years Including the COVID-19 Era br | Background: Studies on how the coronavirus pandemic has affected pediatric inflammatory bowel disease (PIBD) are lacking. We aimed to investigate the trends in epidemiology, characteristics, initial management, and short-term outcomes of PIBD in South Korea over the recent three years including the era of coronavirus disease 2019 (COVID-19).Methods: This multicenter study retrospectively investigated temporal trends in the epidemiology of PIBD in Korea. Annual occurrences, disease phenotypes, and initial management at diagnosis were analyzed from January 2018 to June 2021.Results: A total of 486 patients from 17 institutions were included in this epidemiological evaluation. Analysis of the occurrence trend confirmed a significant increase in PIBD, regardless of the COVID-19 pandemic. In Crohn's disease, patients with post-coronavirus outbreaks had significantly higher fecal calprotectin levels than those with previous onset (1,339.4 +/- 717.04 vs. 1,595.5 +/- 703.94, P = 0.001). Patients with post-coronavirus-onset ulcerative colitis had significantly higher Pediatric Ulcerative Colitis Activity Index scores than those with previous outbreaks (48 +/- 17 vs. 36 +/- 15, P = 0.004). In the initial treatment of Crohn's disease, the use of 5-aminosalicylic acid (5-ASA) and steroids significantly decreased (P = 0.006 and 0.001, respectively), and enteral nutrition and the use of infliximab increased significantly (P = 0.045 and 0.009, respectively). There was a significant increase in azathioprine use during the initial treatment of ulcerative colitis (P = 0.020).Conclusion: Regardless of the COVID-19 pandemic, the number of patients with PIBD is increasing significantly annually in Korea. The initial management trends for PIBD have also changed. More research is needed to establish appropriate treatment guidelines considering the epidemiological and clinical characteristics of Korean PIBD. | Choi, So Yoon; Choi, Sujin; Kang, Ben; Choe, Byung-Ho; Lee, Yeoun Joo; Park, Jae Hong; Kim, Yu Bin; Kim, Jae Young; Lee, Kunsong; Lee, Kyung Jae; Kang, Ki Soo; Lee, Yoo Min; Kim, Hyun Jin; Kang, Yunkoo; Jang, Hyo-Jeong; Yi, Dae Yong; Hong, Suk Jin; Choi, You Jin; Hong, Jeana; Kim, Soon Chul | Kosin Univ Gospel Hosp, Kosin Univ Coll Med, Dept Pediat, Busan, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Childrens Hosp, Sch Med, Dept Pediat, Daegu, South Korea; Pusan Natl Univ Childrens Hosp, Dept Pediat, Yangsan, South Korea; Ajou Univ Sch Med, Dept Pediat, Suwon, South Korea; Gyeongsang Natl Univ, Changwon Hosp, Dept Pediat, Chang Won, South Korea; Dankook Univ Hosp, Dept Pediat, Cheonan, South Korea; Hallym Univ Sacred Heart Hosp, Dept Pediat, Anyang, South Korea; Jeju Natl Univ Hosp, Dept Pediat, Jeju, South Korea; Soonchunhyang Univ, Bucheon Hosp, Coll Med, Dept Pediat, Bucheon, South Korea; Chungnam Natl Univ Hosp, Chungnam Natl Univ Coll Med, Dept Pediat, Daejeon, South Korea; Yonsei Univ Wonju Coll Med, Dept Pediat, Wonju, South Korea; Keimyung Univ Sch Med, Keimyung Univ Dongsan Med Ctr, Dept Pediat, Daegu, South Korea; Chung Ang Univ, Chung Ang Univ Hosp, Coll Med, Dept Pediat, Seoul, South Korea; Daegu Catholic Univ, Sch Med, Dept Pediat, Daegu, South Korea; Inje Univ Ilsan Paik Hosp, Inje Univ Coll Med, Dept Pediat, Goyang, South Korea; Kangwon Natl Univ Sch Med, Dept Pediat, Chunchon, South Korea; Jeonbuk Natl Univ Med Sch & Hosp, Dept Pediat, Jeonju, South Korea; Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Res Inst Clin Med, Biomed Res Inst, Jeonju, South Korea; Jeonbuk Natl Univ Childrens Hosp, Dept Pediat, 20 Geonji ro, Jeonju 54907, South Korea | Lee, Yong Jae/GLR-4153-2022; Lee, Yeoun Joo/AHA-7302-2022; kim, Seok-jun/E-7924-2015; 康, 奔/JMQ-0812-2023; Choe, Byung-Ho/KSM-6251-2024; Yi, Dae/G-1729-2014; Lee, KyungJae/MIO-6255-2025; Kim, Siwon/KHX-9078-2024; Kim, Youngmin/C-7926-2019; lee, dong/I-9385-2017 | 57207282105; 57223972405; 57194823199; 57574977300; 34877162300; 57202928590; 57212382905; 57203251636; 55911172700; 57022460500; 56892514000; 55588928200; 58975661600; 55607051000; 55355948500; 57190851975; 56573097000; 56063619400; 55371401700; 36087407700 | kimsc@jbnu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 37 | 37 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 4.5 | 28.1 | 0.16 | 2025-06-25 | 1 | 1 | Inflammatory Bowel Disease; Pediatric; COVID-19; Occurrence; Management | ENDOSCOPIC ACTIVITY; CROHNS-DISEASE; VALIDATION; MANAGEMENT; OUTCOMES; CHILDREN; INDEX; SCORE | Covid-19; Inflammatory bowel disease; Management; Occurrence; Pediatric | Azathioprine; Colitis, Ulcerative; COVID-19; Crohn Disease; Humans; Inflammatory Bowel Diseases; Infliximab; Leukocyte L1 Antigen Complex; Mesalamine; Pandemics; Republic of Korea; Retrospective Studies; azathioprine; calgranulin; infliximab; mesalazine; clinical trial; Crohn disease; human; inflammatory bowel disease; multicenter study; pandemic; retrospective study; South Korea; ulcerative colitis | English | 2022 | 2022-09-26 | 10.3346/jkms.2022.37.e279 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Evaluation of Current Resources Available for Community-Based Cardiac Rehabilitation in Korea: A Nationwide Survey Study | Background: In Korea, the actual distribution of cardiac rehabilitation (CR) to the clinical field is insufficient due to the many barriers for cardiovascular patients to participate in CR. Community-based CR is a useful alternative to overcome these obstacles. Through a nationwide survey, we investigated the possibility of regional medical and public health management institutes which can be in charge of community-based CR in Korea. Methods: The questionnaires on recognition of CR and current available resources in health-related institutions were developed with reference to the CR evaluation tools of York University and the International Council of Cardiovascular Prevention and Rehabilitation. The questionnaires were sent to regional public and private medical institutions and public health management institutions. Results: In total, 2,267 questionnaires were sent to 1,186 institutions. There were 241 and 242 responses from 173 and 179 regional private and public medical institutions, respectively. And a total of 244 responses were gathered from 180 public health management institutions. Although many institutions were equipped with the necessary facilities for exercise training, there were few patient-monitoring systems during exercise. Most institutions were aware of the need for CR, but were burdened with the cost of establishing personnel and facilities to operate CR. Conclusion: Most regional medical, and public health management institutions in Korea are unprepared for the implementation of community-based CR programs. To encourage the utilization of such, there should be efforts to establish a national consensus. | Kim, Chul; Sung, Jidong; Han, Jae-Young; Jee, Sungju; Lee, Jang Woo; Lee, Jong Hwa; Kim, Won-Seok; Bang, Heui Je; Baek, Sora; Joa, Kyung Lim; Kim, Ae Ryoung; Lee, So Young; Kim, Jihee; Kim, Chung Reen; Kwon, Oh Pum | Inje Univ, Dept Rehabil Med, Sanggye Paik Hosp, Seoul, South Korea; Sungkyunkwan Univ, Div Cardiol, Dept Med, Sch Med, Seoul, South Korea; Chonnam Natl Univ, Chonnam Natl Univ Hosp, Dept Phys Med & Rehabil, Med Sch, Gwangju, South Korea; Chungnam Natl Univ, Chungnam Natl Univ Hosp, Dept Rehabil Med, Coll Med, Daejeon, South Korea; Natl Hlth Insurance Serv Ilsan Hosp, Dept Phys Med & Rehabil, Goyang, South Korea; Dong Univ, Dept Phys Med & Rehabil, Coll Med, Busan, South Korea; Seoul Natl Univ, Seoul Natl Univ Bundang Hosp, Dept Rehabil Med, Coll Med, Seoul, South Korea; Chungbuk Natl Univ, Dept Rehabil Med, Coll Med, Cheongju, South Korea; Kangwon Natl Univ, Dept Rehabil Med, Sch Med, Chunchon, South Korea; Inha Univ Hosp, Dept Phys Med & Rehabil, Incheon, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Rehabil Med, Sch Med, Daegu, South Korea; Jeju Natl Univ, Jeju Natl Univ Hosp, Dept Rehabil Med, Coll Med, Jeju, South Korea; Wonkwang Univ, Wonkwang Univ Hosp, Dept Rehabil Med, Med Sch, Iksan, South Korea; Univ Ulsan, Ulsan Univ Hosp, Dept Phys Med & Rehabil, Coll Med, Ulsan, South Korea | Lee, Jaewon/N-9064-2013; Joa, Kyung-Lim/ABB-3860-2020; jee, sungju/E-8391-2016; , 김원석/AAJ-2334-2020; Han, Jae-Young/AAV-1100-2021 | 55936526100; 57221027209; 15765035600; 56487143900; 55999572900; 55690046100; 57028735900; 55246577800; 55875523200; 55245910100; 57196257330; 57202327370; 55822889900; 35848509700; 55822295300 | medipia@gmail.com; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 37 | 14 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 4.5 | 28.1 | 0.48 | 2025-06-25 | 3 | 3 | Cardiac Rehabilitation; Community Networks; Surveys and Questionnaires; Public Policy | PSYCHOMETRIC VALIDATION; PARTICIPATION | Cardiac Rehabilitation; Community Networks; Public Policy; Surveys and Questionnaires | Cardiac Rehabilitation; Humans; Republic of Korea; Surveys and Questionnaires; heart rehabilitation; human; questionnaire; South Korea | English | 2022 | 2022-04-11 | 10.3346/jkms.2022.37.e109 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Finger Drop-Dominant Variant of Guillain-Barre Syndrome in a Patient With COVID-19: A Case Report | Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 that may trigger Guillain-Barre syndrome (GBS) in selected patients. We describe a case of GBS presenting as marked finger extensor weakness in a 73-year-old woman with COVID-19. Her clinical and electrophysiological findings were consistent with a diagnosis of acute motor axonal neuropathy subtype of GBS with prominent finger dropping. Treatment with intravenous immunoglobulin for 5 days completely resolved her finger extension weakness after 19 months, although other involved extremities recovered earlier at 3 months. This study highlights that COVID-19-associated GBS can present in various forms aside from the classic variant, even in patients without any COVID-19 symptoms. Therefore, it is important to always consider the diagnosis of GBS in patients with COVID-19. | Kang, Minsung; Seok, Hung Youl | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Keimyung Univ, Dongsan Med Ctr, Dept Neurol, Sch Med, 1035 Dalgubeol Daero, Daegu 42601, South Korea | ; Seok, Hung Youl/HZI-4365-2023 | 57719257600; 24472118000 | shy2354@gmail.com; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 37 | 20 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 4.5 | 28.1 | 0.48 | 2025-06-25 | 0 | 3 | Guillain-Barre Syndrome; COVID-19; SARS-CoV-2; Finger Drop | Covid-19; Finger drop; Guillain-barre syndrome; Sars-cov-2 | Aged; COVID-19; Female; Guillain-Barre Syndrome; Humans; Immunoglobulins, Intravenous; Muscle Weakness; SARS-CoV-2; immunoglobulin; aged; case report; complication; female; Guillain Barre syndrome; human; muscle weakness | English | 2022 | 2022-05-23 | 10.3346/jkms.2022.37.e160 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Impact of the COVID-19 Pandemic on Patient Delay and Clinical Outcomes for Patients With Acute Myocardial Infarction | Background: It has been known that the fear of contagion during the coronavirus disease 2019 (COVID-19) creates time delays with subsequent impact on mortality in patients with acute myocardial infarction (AMI). However, difference of time delay and clinical outcome in patients with ST-segment elevation myocardial infarction (STEMI) or non-STEMI between the COVID-19 pandemic and pre-pandemic era has not been fully investigated yet in Korea. The aim of this study was to investigate the impact of COVID-19 pandemic on time delays and clinical outcome in patients with STEMI or non-STEMI compared to the same period years prior. Methods: A total of 598 patients with STEMI (n = 195) or non-STEMI (n = 403) who underwent coronary angiography during the COVID-19 pandemic (February 1 to April 30, 2020) and pre pandemic era (February 1 to April 30, 2017, 2018, and 2019) were analyzed in this study. Main outcomes were the incidence of time delay, cardiac arrest, and in-hospital death. Results: There was 13.5% reduction in the number of patients hospitalized with AMI during the pandemic compared to pre-pandemic era. In patients with STEMI, door to balloon time tended to be longer during the pandemic compared to pre-pandemic era (55.7 +/- 12.6 minutes vs. 60.8 +/- 13.0 minutes, P = 0.08). There were no significant differences in cardiac arrest (15.6% vs. 10.4%, P = 0.397) and in-hospital mortality (15.6% vs. 10.4%, P = 0.397) between pre-pandemic and the pandemic era. In patients with non-STEMI, symptom to door time was significantly longer (310.0 +/- 346.2 minutes vs. 511.5 +/- 635.7 minutes, P = 0.038) and the incidence of cardiac arrest (0.9% vs. 3.5%, P = 0.017) and in-hospital mortality (0.3% vs. 2.3%, P = 0.045) was significantly greater during the pandemic compared to pre-pandemic era. Among medications, angiotensin converting enzyme inhibitors/angiotensin type 2 receptor blockers (ACE-I/ARBs) were underused in STEMI (64.6% vs. 45.8%, P = 0.021) and non-STEMI (67.8% vs. 57.0%, P = 0.061) during the pandemic. Conclusion: During the COVID-19 pandemic, there has been a considerable reduction in hospital admissions for AMI, time delay, and underuse of ACE-I/ARBs for the management of AMI, and this might be closely associated with the excess death in Korea. | Choi, Hyohun; Lee, Jang Hoon; Park, Hyuk Kyoon; Lee, Eunkyu; Kim, Myeong Seop; Kim, Hyeon Jeong; Park, Bo Eun; Kim, Hong Nyun; Kim, Namkyun; Jang, Se Yong; Bae, Myung Hwan; Yang, Dong Heon; Park, Hun Sik; Cho, Yongkeun | Kyungpook Natl Univ Hosp, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea | ; Park, Hang-soo/AEH-1640-2022 | 57723256300; 54581258000; 57221712499; 57722787900; 57371425600; 57204359002; 57201131446; 56706769800; 55887032700; 57207977889; 36607356800; 35277423400; 57198844106; 9249593500 | ljhmh75@knu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 37 | 21 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 4.5 | 28.1 | 1.91 | 2025-06-25 | 13 | 12 | Coronavirus; SARS-CoV-2; COVID-19; Time Delay; Cardiac Arrest; Acute Myocardial Infarction; Prognosis | DISEASE; PCI | Acute myocardial infarction; Cardiac arrest; Coronavirus; Covid-19; Prognosis; Sars-cov-2; Time delay | Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; COVID-19; Heart Arrest; Hospital Mortality; Humans; Myocardial Infarction; Pandemics; ST Elevation Myocardial Infarction; angiotensin receptor antagonist; dipeptidyl carboxypeptidase inhibitor; heart arrest; heart infarction; hospital mortality; human; pandemic; ST segment elevation myocardial infarction | English | 2022 | 2022-05-30 | 10.3346/jkms.2022.37.e167 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Letter | Letter to the Editor: Guillain-Barre Syndrome Needs to Be Considered as a Cause of Idiopathic Bilateral Vocal Fold Paralysis | Kim, Sohyeon; Kang, Minsung; Park, Jin-Sung; Seok, Hung Youl | Keimyung Univ, Dongsan Med Ctr, Sch Med, Dept Neurol, Daegu 42601, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, 807 Hoguk Ro, Daegu 41404, South Korea | ; Seok, Hung Youl/HZI-4365-2023 | 57214724357; 57719257600; 44061744500; 24472118000 | neurojspark@gmail.com;shy2354@gmail.com; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 37 | 41 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 4.5 | 28.1 | 0 | 2025-06-25 | 0 | 0 | COVID-19; Guillain-Barre Syndrome; Humans; RNA, Messenger; Vaccination; Vocal Cord Paralysis; Vocal Cords; messenger RNA; adverse event; Guillain Barre syndrome; human; vaccination; vocal cord; vocal cord paralysis | English | 2022 | 2022-10-24 | 10.3346/jkms.2022.37.e315 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Maternal and Neonatal Outcomes in Pregnant Women With Coronavirus Disease 2019 in Korea | Background: This study aimed to describe the maternal, obstetrical, and neonatal outcomes in pregnant women with coronavirus disease 2019 (COVID-19) and identify the predictors associated with the severity of COVID-19. Methods: This multicenter observational study included consecutive pregnant women admitted because of COVID-19 confirmed using reverse transcriptase-polymerase chain reaction (RT-PCR) test at 15 hospitals in the Republic of Korea between January 2020 and December 2021. Results: A total of 257 women with COVID-19 and 62 newborns were included in this study. Most of the patients developed this disease during the third trimester. Nine patients (7.4%) developed pregnancy-related complications. All pregnant women received inpatient treatment, of whom 9 (3.5%) required intensive care, but none of them died. The gestational age at COVID-19 diagnosis (odds ratio [OR], 1.096, 95% confidence interval [CI], 1.04-1.15) and parity (OR, 1.703, 95% CI, 1.13-2.57) were identified as significant risk factors of severe diseases. Among women who delivered, 78.5% underwent cesarean section. Preterm birth (38.5%), premature rupture of membranes (7.7%), and miscarriage (4.6%) occurred, but there was no stillbirth or neonatal death. The RT-PCR test of newborns' amniotic fluid and umbilical cord blood samples was negative for severe acute respiratory syndrome coronavirus 2. Conclusion: At the time of COVID-19 diagnosis, gestational age and parity of pregnant women were the risk factors of disease severity. Vertical transmission of COVID-19 was not observed, and maternal severity did not significantly affect the neonatal prognosis. | Chung, Youseung; Kim, Eun Jin; Kim, Hee-Sung; Park, Kyung-Hwa; Baek, Ji Hyeon; Kim, Jungok; Lee, Ji Yeon; Lee, Chang-Seop; Lim, Seungjin; Kim, Shin-Woo; Kim, Eu Suk; Shi, Hye Jin; Hong, Shin Hee; Jun, Jae-Bum; Hong, Kyung-Wook; Choi, Jae-Phil; Kim, Jinyeong; Yang, Kyung Sook; Yoon, Young Kyung | Korea Univ, Coll Med, Dept Internal Med, Div Infect Dis, 73 Inchon Ro, Seoul 02841, South Korea; Ajou Univ, Sch Med, Dept Internal Med, Div Infect Dis, Suwon, South Korea; Chungbuk Natl Univ, Coll Med, Dept Internal Med, Cheongju, South Korea; Chonnam Natl Univ, Dept Infect Dis, Med Sch, Gwangju, South Korea; Inha Univ, Coll Med, Dept Internal Med, Div Infect Dis, Incheon, South Korea; Chungnam Natl Univ, Sch Med, Dept Internal Med, Daejeon, South Korea; Chungnam Natl Univ, Sejong Hosp, Div Infect Dis, Sejong, South Korea; Keimyung Univ, Dongsan Hosp, Sch Med, Dept Infect Dis, Daegu, South Korea; Jeonbuk Natl Univ, Dept Internal Med, Med Sch, Jeonju, South Korea; Pusan Natl Univ, Yangsan Hosp, Dept Internal Med, Div Infect Dis, Yangsan, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Internal Med,Div Infect Dis, Seongnam, South Korea; Gachon Univ, Coll Med, Gil Med Ctr, Dept Internal Med,Div Infect Dis, Incheon, South Korea; Univ Ulsan, Ulsan Univ Hosp, Coll Med, Dept Internal Med,Div Infect Dis, Ulsan, South Korea; Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Coll Med, Dept Internal Med, Jinju, South Korea; Seoul Med Ctr, Dept Internal Med, Div Infect Dis, Seoul, South Korea; Hanyang Univ, Guri Hosp, Dept Internal Med, Div Infect Dis, Guri, South Korea; Korea Univ, Coll Med, Dept Biostat, Seoul, South Korea | Kim, Sara/F-2951-2013; Kyung, Yoon/AAS-3428-2020; Kim, Sun/G-3451-2013; Lee, Chang-Seop/IQU-1791-2023; Kim, Eun/AAS-6706-2020; Kim, Jungok/JWP-9097-2024; KIM, SUN/I-9389-2017; Hong, Kyung-Wook/T-3067-2018 | 57226712779; 57207014488; 57210418671; 57219637574; 26644740900; 57207436660; 57216774221; 26423010200; 55633469300; 8710731500; 22938086900; 57204566540; 57727964600; 56402582300; 38461203300; 8635780700; 57222440773; 35270603000; 25947937900 | young7912@korea.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 37 | 41 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 4.5 | 28.1 | 1.91 | 2025-06-25 | 12 | 12 | Severe Acute Respiratory Syndrome Coronavirus 2; Coronavirus Disease 2019; Pregnancy; Neonate | SARS-COV-2 INFECTION; PERINATAL OUTCOMES; COVID-19 | Coronavirus disease 2019; Neonate; Pregnancy; Severe acute respiratory syndrome coronavirus 2 | Cesarean Section; COVID-19; COVID-19 Testing; Female; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Pregnant Women; Premature Birth; RNA-Directed DNA Polymerase; RNA directed DNA polymerase; cesarean section; clinical trial; female; human; multicenter study; newborn; pregnancy; pregnancy complication; pregnancy outcome; pregnant woman; prematurity; vertical transmission | English | 2022 | 2022-10-24 | 10.3346/jkms.2022.37.e297 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Mental Health of Adolescents and Subjective Economic Deterioration Caused by COVID-19 in Korea | Background: The coronavirus disease 2019 (COVID-19) pandemic greatly impacted the health and economy worldwide. Children and adolescents are less affected by COVID-19 but are more vulnerable to secondary damage, such as mental health. We would like to evaluate the subjective economic changes caused by COVID-19 in Korea and adolescents' mental health status. Methods: The data are based on the Korea Youth Risk Behavior Survey, published by the Korea Center for Disease Control and Prevention in South Korea. It is an annual cross-sectional national representative survey of middle and high school students. There were 54,948 subjects, and the survey was conducted from August 3, 2020 to November 13, 2020. We investigated usual stress, loneliness, anxiety, sadness and hopelessness, and suicidal ideation. Results: We found that the odds ratio of adolescent mental health increased as the economic deterioration caused by COVID-19 increased. Overall, it was more severe in female students, and the greater the economic change, the worse the anxiety in boys and the worse the sadness and hopelessness in girls. Conclusion: We hope that it will be possible to prevent and intervene early in adolescents, considering not only the risk of infection from COVID-19 but also mental health, especially mental health related to the economic deterioration caused by COVID-19. | Lee, JaeHyuck; Hong, Seung Wan; Kim, Keonyeop | Keimyung Univ, Sch Med, Dept Family Med, Daegu Dongsan Hosp, Daegu, South Korea; Keimyung Univ, Sch Med, Dept Family Med, Dongsan Hosp, Daegu, South Korea; Kyungpook Natl Univ, Dept Prevent Med, Sch Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea | 58904622600; 57201285880; 35076059600 | pmkky@knu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 37 | 35 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 4.5 | 28.1 | 0.32 | 2025-06-25 | 1 | 2 | COVID-19; Mental Health; Economic Deterioration; Adolescents | SOCIOECONOMIC-STATUS; DISORDER; DEPRESSION; CHILDREN; SUICIDE; ANXIETY; CARE | Adolescents; Covid-19; Economic deterioration; Mental health | English | 2022 | 2022-09-05 | 10.3346/jkms.2022.37.e268 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Nationwide Survey for Pediatric Gastrostomy Tube Placement in Korea | Background: Various methods have been implemented for pediatric gastrostomy tube placement. We aimed to investigate the performance status of pediatric gastrostomy in South Korea and to present indications and appropriate methods for domestic situations.Methods: A survey was conducted among pediatric endoscopists who performed upper gastrointestinal endoscopy in Korea. The questionnaire consisted of 16 questions on gastrostomy performance status.Results: Among the 48 institutions where the survey was applied, 36 (75%) responded. Of the 36 institutions, gastrostomy was performed in 31 (86.1%). The departments in which gastrostomy was performed were pediatrics at 26 institutions (81.3%), surgery at 24 institutions (75.0%), internal medicine at 9 institutions (28.1%), and radiology at 7 institutions (21.9%). There were 18 institutions (66.7%) using the pull method for percutaneous endoscopic gastrostomy (PEG) and nine institutions (33.3%) using the push method. When performing gastrostomies, fundoplication procedures were performed in 19 institutions (61.3%), if deemed necessary. However, 12 institutions (38.7%) answered that gastrostomy was always implemented alone. Complications after gastrostomy included buried bumper syndrome, wound infection, leakage, tube migration, and incorrect opening site in the stomach, but the number of cases with complications was very small.Conclusion: In Korea, a pediatric gastrostomy is implemented in various ways depending on the institution. Clinicians are concerned about choosing the most effective methods with fewer complications after the procedure. In our study, we reported only a few complications. Korea has good accessibility for pediatric gastrointestinal endoscopy, and this survey showed that it is a safe procedure that can be considered initially in pediatric gastrostomy. This study is expected to help to create optimal pediatric PEG guidelines in Korea. | Lee, Sangwoo; Choe, Byung-Ho; Kang, Ben; Kim, Soon Chul | Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Jeonbuk Natl Univ, Med Sch & Hosp, Dept Pediat, Jeonju, South Korea; Jeonbuk Natl Univ, Biomed Res Inst Jeonbuk Natl Univ Hosp, Res Inst Clin Med, Jeonju, South Korea; Jeonbuk Natl Univ, Dept Pediat, Childrens Hosp, 20 Geonji-ro, Jeonju 54907, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, 680 Gukchaebosang-ro, Daegu 41944, South Korea | 康, 奔/JMQ-0812-2023; Choe, Byung-Ho/KSM-6251-2024; Kim, Siwon/KHX-9078-2024 | 57369796700; 57574977300; 57194823199; 36087407700 | benkang@knu.ac.kr;kimsc@jbnu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 37 | 40 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 4.5 | 28.1 | 0.16 | 2025-06-25 | 1 | 1 | Gastrostomy; Pediatrics; Endoscopic Surgical Procedure; Buried Bumper | PERCUTANEOUS ENDOSCOPIC GASTROSTOMY; COMPLICATIONS | Buried bumper; Endoscopic surgical procedure; Gastrostomy; Pediatrics | Child; Enteral Nutrition; Gastrostomy; Humans; Pediatrics; Republic of Korea; Surveys and Questionnaires; child; enteric feeding; gastrostomy; human; pediatrics; procedures; questionnaire; South Korea | English | 2022 | 2022-10-17 | 10.3346/jkms.2022.37.e291 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Potential Utility of Fecal Calprotectin in Discriminating Colorectal Polyps From Other Major Etiologies in Children Presenting With Isolated Hematochezia | Background: Colorectal polyps are the most common cause of isolated hematochezia in children, which requires a colonoscopy for diagnosis. We aimed to investigate the potential utility of fecal calprotectin (FC) in assessing colorectal polyps detected by colonoscopy among children presenting with isolated hematochezia. Methods: Pediatric patients of the age of < 18 years who had undergone both colonoscopy and FC tests for isolated hematochezia from June 2016 to May 2020 were included in the present multicenter, retrospective, cross-sectional study. Comparative analysis was conducted between major causes of isolated hematochezia and FC cut-offs for discriminating colorectal polyps were explored. Results: A total 127 patients were included. Thirty-five patients (27.6%) had colorectal polyps, followed by anal fissure (14.2%), ulcerative colitis (UC; 12.6%), and others. A significant difference in FC levels was observed between patients with colorectal polyps (median, 278.7 mg/kg), anal fissures (median, 42.2 mg/kg), and UC (median, 981 mg/ kg) (P < 0.001). According to receiver operating characteristic curve analysis, among patients diagnosed with colorectal polyp or anal fissure, the most accurate FC cut-off for discriminating colorectal polyps from anal fissures on colonoscopy was 225 mg/kg (sensitivity, 59.4%; specificity, 94.4%; positive predictive value [PPV], 95.0%; negative predictive value [NPV], 56.7%; area under the curve [AUC], 0.8; 95% confidence interval [CI], 0.678-0.923; P < 0.001), while among patients diagnosed with colorectal polyp or UC, the most accurate FC cut-off for discriminating colorectal polyps from UC on colonoscopy was 879 mg/kg (sensitivity, 81.2%; specificity, 56.2%; PPV, 78.8%; NPV, 60.0%; AUC, 0.687; 95% CI, 0.521-0.852; P < 0.001). Conclusion: FC may assist in assessing the cause of lower gastrointestinal tract bleeding in children who present with isolated hematochezia. | Kim, Yu Bin; Kim, Ju Young; Choi, Sujin; Kim, Hyun Jin; Lee, Yoo Min; Lee, Yoon; Jang, Hyo-Jeong; Lee, Eun Hye; Lee, Kyung Jae; Kim, Soon Chul; Choi, So Yoon; Kang, Yunkoo; Yi, Dae Yong; Choi, You Jin; Choe, Byung-Ho; Kang, Ben | Ajou Univ, Dept Pediat, Med Ctr, Suwon, South Korea; Eulji Univ Hosp, Dept Pediat, Daejeon, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Chungnam Natl Univ Hosp, Dept Pediat, Daejeon, South Korea; Soonchunhyang Univ, Coll Med, Dept Pediat, Bucheon Hosp, Bucheon, South Korea; Korea Univ, Dept Pediat, Anam Hosp, Seoul, South Korea; Keimyung Univ, Dongsan Med Ctr, Dept Pediat, Sch Med, Daegu, South Korea; Eulji Univ, Nowon Eulji Med Ctr, Dept Pediat, Sch Med, Seoul, South Korea; Hallym Univ, Dept Pediat, Coll Med, Chunchon, South Korea; Jeonbuk Natl Univ Med Sch & Hosp, Dept Pediat, Jeonju, South Korea; Kosin Univ, Coll Med, Dept Pediat, Gospel Hosp, Busan, South Korea; Yonsei Univ, Dept Pediat, Wonju Coll Med, Wonju, South Korea; Chung Ang Univ, Chung Ang Univ Hosp, Coll Med, Dept Pediat, Seoul, South Korea; Inje Univ, Dept Pediat, Ilsan Paik Hosp, Goyang, South Korea | ; Lee, Yun-Soo/AAA-7364-2022; 康, 奔/JMQ-0812-2023; Kim, Youngmin/C-7926-2019; lee, dong/I-9385-2017; Yi, Dae/G-1729-2014; Choe, Byung-Ho/KSM-6251-2024; Kim, Siwon/KHX-9078-2024; Lee, Yong Jae/GLR-4153-2022 | 57212382905; 57202996384; 57223972405; 58975661600; 55588928200; 55588945800; 55355948500; 57188855950; 57022460500; 36087407700; 57207282105; 55607051000; 57190851975; 56063619400; 57574977300; 57194823199 | benkang@knu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 37 | 9 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 4.5 | 28.1 | 0.16 | 2025-06-25 | 0 | 1 | Fecal Calprotectin; Colorectal Polyp; Anal Fissure; Ulcerative Colitis; Hematochezia | JUVENILE POLYP | Anal fissure; Colorectal polyp; Fecal calprotectin; Hematochezia; Ulcerative colitis | Adolescent; Child; Colonic Polyps; Cross-Sectional Studies; Feces; Female; Gastrointestinal Hemorrhage; Humans; Leukocyte L1 Antigen Complex; Male; Republic of Korea; Retrospective Studies; calgranulin; adolescent; chemistry; child; clinical trial; colon polyp; cross-sectional study; feces; female; gastrointestinal hemorrhage; human; isolation and purification; male; multicenter study; pathophysiology; retrospective study; South Korea | English | 2022 | 2022-03-07 | 10.3346/jkms.2022.37.e72 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Predictors Associated With HIV Status Non-Disclosure in Korea | Background: Human immunodeficiency virus (HIV) disclosure provides personal support to people living with HIV/acquired immunodeficiency syndrome (PLWH). In addition, it has important implications for disease prevention and treatment. Research on disclosure has been conducted worldwide; however, data from South Korea are insufficient. The purpose of this study was to examine whether certain demographic, medical, and psychosocial factors act as predictors of HIV serostatus non-disclosure among PLWH in South Korea. Methods: Participants consisted of 147 PLWH who visited the outpatient infection clinic between June 2020 and January 2021. Demographics, medical factors, HIV-related stigma, and depressive and anxiety symptoms were measured. Results: The overall disclosure rate among participants was 61.2%. Logistic regression analysis showed that lower depression (odds ratio [OR], 0.918; P = 0.021) and higher disclosure concerns (OR, 1.133; P = 0.004) were significant predictors of non-disclosure. Further, married state was a major predictor of non-disclosure when single referred (OR, 3.002; P = 0.024); however, divorce, separation, and widowed status had no significant consequences. Conclusion: In South Korea, the rate of HIV disclosure is lower than in other countries. The higher disclosure concerns, lower depression and married state were suggested to be important predictors of HIV non-disclosure. High level of perceived stigma and experienced discrimination of PLWH may have affected the results. The social atmosphere linking sexual promiscuity and disease may also have influenced these results. Nationwide efforts should continue to reduce the overall stigma and create a social environment where PLWH can feel safe to disclose their disease conditions. | Kim, Kyungmin; Woo, Jungmin | Kyungpook Natl Univ, Sch Med, Dept Psychiat, 130 Dongdeok Ro, Daegu 41944, South Korea | 57201480192; 56241307600 | woojm3@hanmail.net; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 37 | 16 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 4.5 | 28.1 | 0.48 | 2025-06-25 | 2 | 3 | HIV; Disclosure; Stigma; Anxiety; Depression | QUALITY-OF-LIFE; SEROSTATUS DISCLOSURE; SOUTH-INDIA; PEOPLE; STIGMA; DEPRESSION; VALIDATION; YOUNGER; VERSION; OLDER | Anxiety; Depression; Disclosure; HIV; Stigma | Disclosure; HIV Infections; Humans; Republic of Korea; Sexual Behavior; Social Stigma; epidemiology; human; Human immunodeficiency virus infection; interpersonal communication; psychology; sexual behavior; social stigma; South Korea | English | 2022 | 2022-04-25 | 10.3346/jkms.2022.37.e125 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | The Association Between Temperament and Characteristics, Smartphone App Use Patterns and Academic Performance of University Students | Background: Smartphone use patterns may predict daily life efficacy and performance improvements in sports. Additionally, personal characteristics may be associated with smartphone overuse. Methods: We investigated the correlation between the temperament and character inventory (TCI) and academic performance using smartphone log data. We hypothesized that the elite and general groups, divided based on academic performance, differed according to the TCI and downloadable smartphone apps (applications). Additionally, we hypothesized a correlation between smartphone app usage patterns and TCI. A total of 151 students provided smartphone log data of the previous four weeks. They also completed the TCI and provided academic records of the previous year. Results: The first and second most frequently used apps by both groups of students were social networking and entertainment, respectively. Elite students scored higher on novelty seeking, reward dependence, persistence, self-directedness, and self-transcendence than general students. In all participants, the usage time of serious apps was correlated with the scores for novelty seeking (r = 0.32, P < 0.007), reward dependence (r = 0.32, P < 0.007), and self-transcendence (r = 0.35, P < 0.006). In the elite group, the usage time of serious apps was correlated with the scores for novelty seeking (r = 0.45, P < 0.001), reward dependence (r = 0.39, P = 0.022), and self-transcendence (r = 0.35, P = 0.031). In the general group, the usage time of serious apps was correlated only with self-transcendence (r = 0.32, P < 0.007). Conclusion: High usage time of serious apps can help sports majors to excel academically. Particularly among sports majors, serious apps are related to activity, the desire for rewards and recognition, and the tendency to transcend themselves. | Lee, Jea Woog; Park, Sung Je; Kim, Soyeon; Chung, Un Sun; Han, Doug Hyun | Chung Ang Univ, Coll Sport Sci, Anseong, South Korea; Chung Ang Univ, Sch Med, Dept Psychiat, 84 Heukseok Ro, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Psychiat, Daegu, South Korea | ; Jea-Woog, Lee/HDO-0715-2022 | 57217636196; 57209260991; 57228323200; 24477437300; 8774251600 | hduk70@gmail.com; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 37 | 17 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 4.5 | 28.1 | 0.16 | 2025-06-25 | 1 | 1 | Smartphone Log Data; Data Science; Temperament and Character Inventory; Novelty Seeking; Reward Dependence; Serious App | TRIDIMENSIONAL PERSONALITY QUESTIONNAIRE; SOCIAL MEDIA; SELF-TRANSCENDENCE; COLLEGE-STUDENTS; UNITED-STATES; SCREEN TIME; CELL PHONE; SPORT; TRAITS; USAGE | Data Science; Novelty Seeking; Reward Dependence; Serious App; Smartphone Log Data; Temperament and Character Inventory | Academic Performance; Humans; Mobile Applications; Personality Inventory; Students; Temperament; Universities; academic achievement; human; mobile application; personality test; student; temperament; university | English | 2022 | 2022-05-02 | 10.3346/jkms.2022.37.e143 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The Changes in Epidemiology of Imipenem-Resistant Acinetobacter baumannii Bacteremia in a Pediatric Intensive Care Unit for 17 Years | Background: Acinetobacter baumannii infections cause high morbidity and mortality in intensive care unit (ICU) patients. However, there are limited data on the changes of long-term epidemiology of imipenem resistance in A. baumannii bacteremia among pediatric ICU (PICU) patients. Methods: A retrospective review was performed on patients with A. baumannii bacteremia in PICU of a tertiary teaching hospital from 2000 to 2016. Antimicrobial susceptibility tests, multilocus sequence typing (MLST), and polymerase chain reaction for antimicrobial resistance genes were performed for available isolates. Results: A. baumannii bacteremia occurred in 27 patients; imipenem-sensitive A. baumannii (ISAB, n = 10, 37%) and imipenem-resistant A. baumannii (IRAB, n = 17, 63%). There was a clear shift in the antibiogram of A. baumannii during the study period. From 2000 to 2003, all isolates were ISAB (n = 6). From 2005 to 2008, both IRAB (n = 5) and ISAB (n = 4) were isolated. However, from 2009, all isolates were IRAB (n = 12). Ten isolates were available for additional test and confirmed as IRAB. MLST analysis showed that among 10 isolates, sequence type 138 was predominant (n = 7). All 10 isolates were positive for OXA-23-like and OXA-51-like carbapenemase. Of 27 bacteremia patients, 11 were male (41%), the median age at bacteremia onset was 5.2 years (range, 0-18.6 years). In 33% (9/27) of patients, A. baumannii was isolated from tracheal aspirate prior to development of bacteremia (median, 8 days; range, 5-124 days). The overall case-fatality rate was 63% (17/27) within 28 days. There was no statistical difference in the case fatality rate between ISAB and IRAB groups (50% vs. 71%; P = 0.422). Conclusion: IRAB bacteremia causes serious threat in patients in PICU. Proactive infection control measures and antimicrobial stewardship are crucial for managing IRAB infection in PICU. | Kim, Dongsub; Lee, Haejeong; Choi, Joon-sik; Croney, Christina M.; Park, Ki-Sup; Park, Hyo Jung; Cho, Joongbum; Son, Sohee; Kim, Jin Yeong; Choi, Soo-Han; Huh, Hee Jae; Ko, Kwan Soo; Lee, Nam Yong; Kim, Yae-Jean | Sungkyunkwan Univ, Samsung Med Ctr, Dept Pediat, Sch Med, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Pediat, Daegu, South Korea; Yonsei Univ, Severance Childrens Hosp, Inst Immunol & Immunol Dis, Dept Pediat,Coll Med, Seoul, South Korea; Yonsei Univ, Yongin Severance Hosp, Dept Pediat, Coll Med, Yongin, South Korea; Univ Alabama Birmingham, Dept Pediat, Birmingham, AL USA; Samkwang Med Labs Genetree, Seoul, South Korea; Sungkyunkwan Univ, Dept Clin Res Design & Evaluat, SAIHST, Seoul, South Korea; Samsung Med Ctr, Dept Pharmaceut Serv, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Crit Care Med, Sch Med, Seoul, South Korea; Samsung Biomed Res Inst, Seoul, South Korea; Pusan Natl Univ, Pusan Natl Univ Hosp, Sch Med, Dept Pediat, Busan, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Lab Med & Genet, Sch Med, Seoul, South Korea; Sungkyunkwan Univ, Dept Microbiol, Sch Med, Seoul, South Korea; Samsung Adv Inst Hlth Sci & Technol SAIHST, Seoul, South Korea | Park, Jinkyeong/GLV-1649-2022; lee, jaecheol/AAS-3747-2020; Kim, Junetae/AAS-1234-2021 | 57205248455; 57201872364; 57205245521; 55236696700; 56465203700; 57221071745; 50360978300; 57651046200; 57750797300; 55841482200; 47861251300; 7202689224; 55663152100; 7410198066 | yaejeankim@skku.edu; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 37 | 24 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 4.5 | 28.1 | 2.23 | 2025-06-25 | 14 | 14 | Pediatric Intensive Care Units; Acinetobacter baumannii; Bacteremia | CARBAPENEM-RESISTANT; MOLECULAR EPIDEMIOLOGY; ANTIMICROBIAL RESISTANCE; BAUMANNII BACTEREMIA; RISK-FACTORS; INFECTIONS; CLONES; SUSCEPTIBILITY; IDENTIFICATION; SURVEILLANCE | Acinetobacter baumannii; Bacteremia; Pediatric intensive care units | Acinetobacter baumannii; Acinetobacter Infections; Anti-Bacterial Agents; Bacteremia; beta-Lactamases; Child; Cross Infection; Female; Humans; Imipenem; Intensive Care Units, Pediatric; Male; Microbial Sensitivity Tests; Multilocus Sequence Typing; antiinfective agent; beta lactamase; imipenem; Acinetobacter baumannii; Acinetobacter infection; bacteremia; child; cross infection; female; genetics; human; male; microbial sensitivity test; multilocus sequence typing; pediatric intensive care unit | English | 2022 | 2022-06-20 | 10.3346/jkms.2022.37.e196 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Vedolizumab Is Safe and Efficacious for the Treatment of Pediatric-Onset Inflammatory Bowel Disease Patients Who Fail a Primary Biologic Agent | Background: Vedolizumab (VDZ) is currently licensed for use in adults for the treatment of inflammatory bowel disease (IBD). We aimed to investigate the clinical course of pediatric-onset IBD following treatment with VDZ as more than a secondary biologic agent. We also evaluated factors associated with secondary loss of response (LOR) and durability of VDZ treatment. Methods: Pediatric-onset IBD patients diagnosed at an age younger than 18 years who had received VDZ as more than a secondary biologic agent were included in this retrospective observational study conducted at the Department of Pediatrics of two centers in Korea. Comparative analysis was conducted between groups divided according to the development of secondary LOR during VDZ treatment. Results: A total of 24 patients comprising 10 patients with Crohn's disease and 14 with ulcerative colitis were included. Of these, 19 were male and 5 were female. The mean age at diagnosis was 14.6 +/- 2.5 years. The mean age at initiation of VDZ was 20.5 +/- 2.8 years. Nine patients (37.5%) had received two or more biologic agents before starting VDZ. During a median of 0.9 years follow-up from VDZ initiation, 9 patients (37.5%) experienced LOR requiring interval shortening and 4 patients (16.7%) were changed to a different biologic agent. According to multivariate Cox proportional hazard regression analysis, administration of two or more biologic agents before VDZ treatment was the only factor positively associated with LOR (hazard ratio [HR], 5.6; 95% confidence interval [CI], 1.026-30.56; P = 0.047), while LOR was the only factor negatively associated with VDZ durability (HR, 0.003; 95% CI, 0.00-0.08; P = 0.010). No adverse events were observed during treatment with VDZ. Conclusion: VDZ is safe and efficacious for the treatment of pediatric-onset IBD patients failing a primary biologic agent. The durability of VDZ may be enhanced by introducing VDZ earlier in the disease course. Further prospective studies in children are required in the future to validate these findings. | Choi, Sujin; Kim, Eun Sil; Kwon, Yiyoung; Kim, Mi Jin; Choe, Yon Ho; Choe, Byung-Ho; Kang, Ben | Kyungpook Natl Univ, Sch Med, Dept Pediat, 680 Gukchaebosangro, Daegu 41944, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Pediat, Sch Med, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Pediat, Sch Med, Seoul, South Korea | Choe, Byung-Ho/KSM-6251-2024; 康, 奔/JMQ-0812-2023; Kim, Mi Jin/GXH-9639-2022 | 57223972405; 57205500267; 57211905573; 56638815200; 21333712100; 57574977300; 57194823199 | benkang@knu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 37 | 37 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 4.5 | 28.1 | 0 | 2025-06-25 | 1 | 1 | Vedolizumab; Inflammatory Bowel Disease; Crohn Disease; Ulcerative Colitis; Efficacy; Safety | MAINTENANCE THERAPY; CROHNS-DISEASE; MULTICENTER EXPERIENCE; INDUCTION THERAPY | Crohn disease; Efficacy; Inflammatory bowel disease; Safety; Ulcerative colitis; Vedolizumab | Adolescent; Adult; Antibodies, Monoclonal, Humanized; Biological Factors; Child; Colitis, Ulcerative; Female; Gastrointestinal Agents; Humans; Inflammatory Bowel Diseases; Male; Prospective Studies; Retrospective Studies; biological factor; gastrointestinal agent; monoclonal antibody; vedolizumab; adolescent; adult; child; female; human; inflammatory bowel disease; male; prospective study; retrospective study; ulcerative colitis | English | 2022 | 2022-09-26 | 10.3346/jkms.2022.37.e282 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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