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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Comparative Study of 3-Dimensional-Printed Poly-L-Lactic Acid/Bone Morphogenetic Protein (BMP)/Collagen Bone Substitute and Commercial Hydroxyapatite/BMP for Bone Regeneration Efficacy Using a Mouse Calvarial Model | Background: Bone substitutes such as hydroxyapatite (HA) ceramic and recombinant bone morphogenetic protein-2 (BMP-2) are essential in treating bone defects. However, the challenges of controlled and localized BMP-2 delivery necessitate the development of advanced bone graft substitutes. This study introduces and evaluates an innovative, ready-to-use bone substitute employing 3-dimensional-printed poly-L-lactic acid (PLLA) scaffolds combined with BMP-2 to enhance bone regeneration efficiency. Methods: We conducted a comparative study using C57BL/6 mice to evaluate the efficacy of rhBMP-2-coated PLLA scaffolds against traditional HA-based bone graft materials. The PLLA scaffolds were coated with varying concentrations of BMP-2 using an alginate-catechol method. Bone regeneration was assessed through micro-computed tomography (CT) imaging and histological analysis 4 weeks after implantation. The statistical significance of bone mass and formation differences across groups was determined using Student t-test and analysis of variance. Results: Micro-CT analysis revealed substantial bone formation in the group with PLLA scaffolds containing 0.1% BMP-2, exhibiting a bone volume ratio of 11.1% +/- 2.8%, significantly higher than all other groups (p = 0.008). Histological analysis corroborated these findings, showing dense collagen deposition and active osteoblast presence in this group, indicating enhanced bone regeneration. Conclusions: The novel PLLA scaffold with alginate-catechol-coated BMP-2 significantly enhances bone regeneration compared to traditional bone graft materials. This innovative approach holds promising potential for clinical applications in orthopedics, particularly for treating bone defects. | Kim, Tae Ho; Hong, Yu Ri; Lim, Jeong Ok; Oh, Chang-Wug | Kyungpook Natl Univ Hosp, Biomed Res Inst, Daegu, South Korea; Kyungpook Natl Univ, Joint Inst Regenerat Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Orthoped Surg, 130 Dongdeok Ro, Daegu 41944, South Korea | Oh, Chang-Wug/AAO-4602-2021 | 57206927313; 58003346100; 59702737400; 22135834200 | jolim@knu.ac.kr; cwoh@knu.ac.kr; | CLINICS IN ORTHOPEDIC SURGERY | CLIN ORTHOP SURG | 2005-291X | 2005-4408 | 17 | 2 | SCIE | ORTHOPEDICS | 2024 | 2 | 44.2 | 0 | 2025-05-07 | 0 | 0 | Bone morphogenetic protein 2; Three-dimensional; Poly (L-lactide); Bone substitute; Hydroxyapatite | DRUG-DELIVERY SYSTEMS | Bone morphogenetic protein 2; Bone substitute; Hydroxyapatite; Poly (L-lactide); Three-dimensional | Animals; Bone Morphogenetic Protein 2; Bone Regeneration; Bone Substitutes; Collagen; Durapatite; Mice; Mice, Inbred C57BL; Polyesters; Printing, Three-Dimensional; Skull; Tissue Scaffolds; X-Ray Microtomography; alginic acid; catechol; collagen; hydroxyapatite; pentobarbital; polylactic acid; recombinant bone morphogenetic protein 2; bone morphogenetic protein 2; hydroxyapatite; polyester; polylactide; animal cell; animal experiment; animal tissue; Article; bone defect; bone density; bone graft; bone mass; bone regeneration; bone volume; C57BL 6 mouse; calvaria; chemical procedures; clinical effectiveness; comparative study; concentration (parameter); controlled study; histology; implantation; male; micro-computed tomography; mouse; nonhuman; orthopedics; ossification; osteoblast; postoperative period; statistical significance; Student t test; three dimensional printing; animal; bone prosthesis; C57BL mouse; diagnostic imaging; drug effect; micro-computed tomography; pharmacology; skull; surgery; tissue scaffold | English | 2025 | 2025-04 | 10.4055/cios24323 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Hyperlipidemia and Rotator Cuff Tears: Exploring Mechanisms and Effective Treatment | The detrimental effects of hyperlipidemia on the healing of rotator cuff tears are well documented. The proposed underlying mechanisms for these effects include alterations in the extracellular matrix, inflammation, and oxidative stress, which hamper the reparative processes in the affected tendon tissues. Recent therapeutic strategies target these pathways, reflecting a growing body of research dedicated to mitigating these effects and promoting healing. This literature review aims to provide a comprehensive understanding of the pathophysiology underlying rotator cuff tears, examine the interplay between hyperlipidemia and rotator cuff tear healing, synthesize current knowledge on contributing biological mechanisms, and outline potential therapeutic interventions to optimize clinical management and treatment outcomes for patients. | Lee, Kang-San; Park, Sung-Jin; Kim, Dong-Hyun; Chung, Seok Won; Kim, Jun-Young; Cho, Chul-Hyun; Yoon, Jong Pil | Kyungpook Natl Univ Hosp, Dept Orthoped Surg, 130 Dongdeok Ro, Daegu 41944, South Korea; Konkuk Univ, Med Ctr, Dept Orthoped Surg, Seoul, South Korea; Daegu Catholic Univ, Sch Med, Dept Orthoped Surg, Daegu, South Korea; Keimyung Univ, Sch Med, Dept Orthoped Surg, Daegu, South Korea | 58967020700; 58527890700; 57198637188; 37065938600; 57201935381; 35785599900; 36098548400 | altjp1@gmail.com; | CLINICS IN ORTHOPEDIC SURGERY | CLIN ORTHOP SURG | 2005-291X | 2005-4408 | 17 | 2 | SCIE | ORTHOPEDICS | 2024 | 2 | 44.2 | 0 | 2025-05-07 | 0 | 0 | Rotator cuff tear; Hyperlipidemia; Inflammation; Oxidative stress | NONSTEROIDAL ANTIINFLAMMATORY DRUGS; BODY-MASS INDEX; FATTY INFILTRATION; TENDON; REPAIR; HYPERCHOLESTEROLEMIA; MANAGEMENT; SEVERITY; STATINS; DISEASE | Hyperlipidemia; Inflammation; Oxidative stress; Rotator cuff tear | Humans; Hyperlipidemias; Oxidative Stress; Rotator Cuff Injuries; Wound Healing; cholesterol; cyclooxygenase 2 inhibitor; low density lipoprotein; nonsteroid antiinflammatory agent; simvastatin; triacylglycerol; vitamin D; Article; cholesterol blood level; gene expression; human; hyperlipidemia; inflammation; lipoprotein blood level; nonhuman; oxidative stress; pathophysiology; protein expression; rotator cuff repair; rotator cuff rupture; triacylglycerol blood level; vitamin blood level; vitamin D deficiency; xanthoma; hyperlipidemia; rotator cuff injury; surgery; therapy; wound healing | English | 2025 | 2025-04 | 10.4055/cios24301 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Effects of motivations for news consumption on intention to purchase paid news service in the changing news media environment | This study examined the effects of motivations for news consumption on paying intention for paid news services, highlighting the mediating role of news use behavior and news dependency. The study found that the motivation of surveillance was negatively associated with paying intention, while the motivation of entertainment was positively associated with the outcome variable. The negative association between the motivation of surveillance and paying intention is different from the findings of previous studies. It implies that for those who consume news with the motivation of surveillance, news service could be perceived as a given, and thus, they are not willing to pay for the traditional function of news. This is an important finding and contribution, considering that the study elaborated on which motivation was linked to the outcome variable and in what direction. In addition, the study's findings ask the news industry and news practitioners to make the balance between the news function of information provision and that of entertainment not only to maintain the traditional value of news but also to maximize news consumers' willingness to pay for paid news service. © AMIC/WKWSCI-NTU 2025. | Park, Namkee; Kim, Yeonshik | Department of Communication, Yonsei University, Seoul, South Korea; Department of Journalism and Mass Communications, Kyungpook National University, Daegu, South Korea | 18038495600; 59931918000 | npark@yonsei.ac.kr; | Asian Journal of Communication | ASIAN J COMMUN | 0129-2986 | 1742-0911 | SSCI | COMMUNICATION | 2024 | 1.5 | 44.3 | N/A | 0 | Motivations; news dependency; news use; paying intention for paid news services | English | Article in press | 2025 | 10.1080/01292986.2025.2509526 | 바로가기 | 바로가기 | 바로가기 | |||||||||||
| ○ | ○ | Review | Inorganic Solid-State Electrolytes for Solid-State Sodium Batteries: Electrolyte Design and Interfacial Challenges | Recent advancements in inorganic solid electrolytes (ISEs), achieving sodium (Na)-ion conductivities exceeding 10 -2 S cm-1 at room temperature (RT), have generated significant interest in the development of solid-state sodium batteries (SSSBs). However, the ISEs face challenges such as their limited electrochemical stability windows (ESWs) and compatibility issues with high-capacity, high-voltage cathode materials and Na metal anodes. The success of high-performance SSSBs hinges on developing ideal ISEs that deliver high Na+ ion conductivities, robust chemical and electrochemical stability, and well constructed electrode/ISE interfaces. This review explores the fundamental principles and strategies to optimize SSSB performance by addressing issues related to ISEs and their interfaces, emphasizing that many interfacial challenges are intrinsically linked to ISE properties. It highlights recent advancements in ISE research, including the mechanisms of Na-ion conduction and the key factors influencing it, such as crystal structure, lattice dynamics, point defects, and grain boundaries. It also discusses prototyping strategies for cell design from the perspectives of material and defect chemistry. Additionally, the review identifies key challenges and future opportunities for advancing SSSBs and provides rational solutions to guide future research toward the practical realization of high-performance SSSBs.Keywords: Solid-state sodium batteries; Inorganic solid electrolytes; Interfacial mechanism; Electrochemical stability window; Ionic conductivity; Modification strategies | Lee, Dongsoo; Kakarla, Ashok Kumar; Sun, Seho; Kim, Patrick Joohyun; Choi, Junghyun | Gachon Univ, Sch Chem Biol & Battery Engn, Seongnam Si 13120, Gyeonggi Do, South Korea; Yeungnam Univ, Sch Chem Engn, Gyongsan 38541, South Korea; Kyungpook Natl Univ, Dept Appl Chem, Daegu 41566, South Korea | ; Lee, Dongsoo/AAY-4231-2021; KAKARLA, ASHOK KUMAR/KDM-7470-2024; Sun, Seho/LIC-4232-2024 | 57201799820; 58668090400; 56799447300; 57195611779; 59883103900 | pjkim@knu.ac.kr; junghchoi@gachon.ac.kr; | CHEMELECTROCHEM | CHEMELECTROCHEM | 2196-0216 | 12 | 3 | SCIE | ELECTROCHEMISTRY | 2024 | 3.5 | 44.3 | 0 | 2025-05-07 | 0 | 0 | NA-ION BATTERIES; ROOM-TEMPERATURE; BETA-ALUMINA; SUPERIONIC CONDUCTOR; ENERGY-STORAGE; LITHIUM; METAL; DIFFUSION; TRANSPORT; NA3PS4 | Anode materials; Cathode materials; Crystal lattices; Point defects; Single crystals; Sodium-ion batteries; Solid electrolytes; Battery electrolyte; Electrochemical stabilities; High capacity; Inorganic solid electrolytes; Inorganic solids; Ion conductivities; Na+ ions; Performance; Sodium battery; Solid-state electrolyte; Grain boundaries | English | 2025 | 2025-02-01 | 10.1002/celc.202400612 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Broad Antibacterial Activity and Mechanism of Garlic (Allium sativum L. cv. Uiseong) Extracts against Cell Wall of Aeromonas hydrophila | Aeromonas hydrophila is a pathogenic bacterium known for its resistance to antibiotics and its ability to cause infections in aquatic environments. This has made disease management more complex, making the development of alternative antimicrobial agents necessary. Uiseong garlic is a superior variety from Republic of Korea, renowned for its high level of beneficial compounds, making it a promising candidate for natural antimicrobial application. Therefore, this study aimed to investigate the antibacterial activity and mechanism of Uiseong garlic extracts against the cell wall of A. hydrophila. Uiseong garlic extracts were prepared using water and ethanol at 22oC and 90oC, respectively. The antibacterial activities of Uiseong garlic extracts were evaluated for their yield, antibacterial dynamics, leakage of bacterial intracellular proteins, and changes in morphological characteristics. Uiseong garlic extracts at 22oC exhibited significant antibacterial activities against foodborne pathogens, particularly against 9 strains of A. hydrophila. In this study, the ethanol extract at 22oC demonstrated significantly higher antibacterial activity compared to the water extract at 22oC, with a similar pattern of antimicrobial dynamics with polymyxin B. The ethanol extract at 22oC caused a higher concentration of leaked bacterial proteins (92.87 +/- 0.46 mu g/ml), indicating cell membrane disruption. Additionally, transmission electron microscopy analysis further confirmed that both extracts induced plasmolysis, leading to notable damage to the bacterial cell membrane. Therefore, ethanol extract of Uiseong garlic was demonstrated as a promising alternative to antibiotics for controlling A. hydrophila. | Artawinata, Putri Christy; Kim, Youjin; Choi, In Young; Park, Mi-Kyung | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Food & Bioind Res Inst, Daegu 41566, South Korea; Univ Wisconsin Madison, Dept Food Sci, Madison, WI 53706 USA | Park, Mi-Kyung/J-9643-2017 | 58303173200; 57190286137; 57200112496; 7404491155 | parkmik@knu.ac.kr; | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | J MICROBIOL BIOTECHN | 1017-7825 | 1738-8872 | 35 | SCIE | MICROBIOLOGY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 3.1 | 44.4 | 0 | 2025-05-07 | 0 | 0 | Uiseong garlic; A. hydrophila; broad antibacterial activity; protein leakage; bacterial cell membrane disruptions | DRINKING-WATER | A. hydrophila; bacterial cell membrane disruptions; broad antibacterial activity; protein leakage; Uiseong garlic | Aeromonas hydrophila; Anti-Bacterial Agents; Bacterial Proteins; Cell Wall; Garlic; Microbial Sensitivity Tests; Plant Extracts; Republic of Korea; alcohol; ampicillin; bacterial protein; garlic extract; polymyxin B; water; antiinfective agent; bacterial protein; plant extract; Aeromonas hydrophila; antibacterial activity; antibiotic resistance; Article; Bacillus cereus; bacterial cell wall; bacterial strain; controlled study; drug dosage form comparison; drug mechanism; Escherichia coli; foodborne pathogen; garlic; Korea; Listeria monocytogenes; membrane damage; microbial morphology; minimum inhibitory concentration; nonhuman; plasmolysis; Pseudomonas aeruginosa; Salmonella enterica serovar Enteritidis; Shigella sonnei; Staphylococcus aureus; temperature; transmission electron microscopy; Vibrio parahaemolyticus; Yersinia enterocolitica; cell wall; chemistry; drug effect; garlic; metabolism; microbial sensitivity test; South Korea | English | 2025 | 2025 | 10.4014/jmb.2410.10035 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Characterization of Blue Light Receptors LreA and LreB in Aspergillus flavus | Light is a key external signal factor that regulates asexual development, stress resistance, and secondary metabolism in fungi. In the presence of light, photoreceptors sense several light receptors and affect fungal life. In this study, we characterized the function of the blue light receptors LreA and LreB in Aspergillus flavus, a potent pathogenic and toxigenic fungus. lreA or lreB deletion increased the growth rate but decreased conidial production in the presence or absence of light. The DlreA- mutant strain and the DlreB-mutant strain produced abnormal conidiophores, suggesting that lreA and lreB were essential for proper conidiation in A. flavus. The absence of lreA or lreB slightly decreased the stress response tolerance against thermal and oxidative stresses. In kernel infection, the DlreA mutant strain and the DlreB mutant strain produced conidia and aflatoxin B1 that were less than those produced by the control strains. Therefore, LreA and LreB play key roles in the growth, asexual development, and pathogenicity of A. flavus. | Park, Hye-Min; Son, Ye-Eun; Cho, He-Jin; Yu, Jae-Hyuk; Park, Hee-Soo | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Univ Wisconsin Madison, Dept Bacteriol, Madison, WI 53706 USA; Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea | Park, Hee-Soo/AAC-6422-2019 | 58943284900; 57200513491; 57214721558; 7405531243; 15751448400 | phsoo97@knu.ac.kr; | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | J MICROBIOL BIOTECHN | 1017-7825 | 1738-8872 | 35 | SCIE | MICROBIOLOGY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 3.1 | 44.4 | 0 | 2025-05-07 | 0 | 0 | Aspergillus flavus; light receptors; LreA; LreB; asexual development | WHITE; SENSORS; DOMAINS; PAS | asexual development; Aspergillus flavus; light receptors; LreA; LreB | Aflatoxin B1; Aspergillus flavus; Blue Light; Fungal Proteins; Gene Deletion; Gene Expression Regulation, Fungal; Light; Oxidative Stress; Photoreceptors, Microbial; Spores, Fungal; Stress, Physiological; Zea mays; aflatoxin B1; fungal protein; LreA protein; LreB protein; unclassified drug; aflatoxin B1; fungal protein; visual proteins and pigments; Article; Aspergillus flavus; conidium; controlled study; fungal development; fungal strain; fungal virulence; growth rate; nonhuman; oxidative stress; physiological stress; protein analysis; protein function; protein targeting; strain difference; biosynthesis; blue light; fungus spore; gene deletion; gene expression regulation; genetics; growth, development and aging; light; maize; metabolism; microbiology; radiation response | English | 2025 | 2025 | 10.4014/jmb.2411.11054 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Characterization of Protosiphon botryoides KNUA219 Isolated from Dokdo Island as a Potential Biofuel Resource | The increasing demand for sustainable and eco-friendly energy sources has intensified research into alternative biofuel feedstocks. Microalgae, recognized for their rapid growth and production of high-value products, have emerged as promising candidates for third-generation biofuels. This study evaluates the potential of Protosiphon botryoides KNUA219, a microalga isolated from Dokdo Island, South Korea, as a biodiesel feedstock. Molecular and morphological analyses confirmed its identity, while growth experiments demonstrated its species-specific physiological characteristics, including an optimal pH range of 5-7, limited salinity tolerance, and high biomass productivity. Biochemical analysis revealed significant levels of carbohydrates (30.42 +/- 1.65%), proteins (26.18 +/- 1.14%), and lipids (14.86 +/- 0.33%) in P. botryoides KNUA219, with glucose and galactose as the dominant monosaccharides. Fatty acid methyl ester profiling identified a lipid composition consisting of saturated (20.54%), monounsaturated (19.03%), and polyunsaturated fatty acids (42.65%), with palmitic, oleic, and linolenic acids as key components. Biodiesel quality assessments indicated compliance with critical standards for cetane number and cold filter plugging point, although optimization was required for iodine value and density. Proximate and ultimate analyses revealed favorable energy properties, including a high volatile matter content (88.94 +/- 0.33%) and a calorific value of 23.11 +/- 0.11 MJ/kg. These findings establish P. botryoides KNUA219 as a promising and sustainable resource for biodiesel production, while highlighting its potential for broader industrial applicability. | Noh, Hae-Seo; Do, Jeong-Mi; Suh, Ho-Seong; Park, Su-Bin; Yoon, Ho-Sung | Kyungpook Natl Univ, Dept Biol, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat Biores Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Integrated Blue Carbon Res Ctr, Adv Bioresource Res Ctr, Daegu 41566, South Korea; Nakdonggang Natl Inst Biol Resources NNIBR, Biol Resources Res Dept, Sangju 37242, South Korea | Park, Su-Bin/IVH-9442-2023 | 59670381700; 57208562245; 58139501200; 57201732680; 7402990205 | hsy@knu.ac.kr; | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | J MICROBIOL BIOTECHN | 1017-7825 | 1738-8872 | 35 | SCIE | MICROBIOLOGY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 3.1 | 44.4 | 0 | 2025-05-07 | 0 | 0 | Microalgae; Protosiphon; biomass; high-value products; biodiesel | MICROALGAE; BIODIESEL; GROWTH; PURIFICATION; OIL; PH | biodiesel; biomass; high-value products; Microalgae; Protosiphon | Biofuels; Biomass; Fatty Acids; Glucose; Hydrogen-Ion Concentration; Islands; Lipids; Microalgae; Monosaccharides; Phylogeny; Republic of Korea; RNA, Ribosomal, 16S; algal protein; biodiesel; biofuel; carbohydrate; fatty acid ester; galactose; glucose; linolenic acid; lipid; monosaccharide; monounsaturated fatty acid; oleic acid; palmitic acid; polyunsaturated fatty acid; saturated fatty acid; volatile organic compound; biofuel; fatty acid; glucose; lipid; monosaccharide; RNA 16S; algal growth; Article; biochemical analysis; biofuel resource; biomass production; controlled study; energy resource; fatty acid analysis; isolation procedure; lipid composition; microalga; microalga characterization; microalga isolation; microorganism detection; molecular diagnosis; morphology; nonhuman; pH; physiology; Protosiphon botryoides KNUA219; quality control; salt tolerance; South Korea; biomass; chemistry; genetics; growth, development and aging; island (geological); metabolism; phylogeny; South Korea | English | 2025 | 2025 | 10.4014/jmb.2411.11065 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Comparative Analysis of Codon Optimization Tools: Advancing toward a Multi-Criteria Framework for Synthetic Gene Design | Codon optimization is an essential technique in synthetic biology and biopharmaceutical production, enhancing recombinant protein expression by fine-tuning genetic sequences to match the translational machinery and codon usage preferences of specific host organisms. This study presents a comprehensive comparative analysis of widely used codon optimization tools, focusing on their capacity to reflect host-specific codon biases, design principles, and parameters. Industrially relevant target proteins were evaluated in Escherichia coli, Saccharomyces cerevisiae, and CHO cells, uncovering significant variability in sequence design and clustering patterns across tools. Tools such as JCat, OPTIMIZER, ATGme, and GeneOptimizer demonstrated strong alignment with genomewide and highly expressed gene-level codon usage, achieving high codon adaptation index (CAI) values and efficient co don-pair utilization. Conversely, tools like TISIGNER and IDT employed different optimization strategies that frequently produced divergent results. Other key parameters, including GC content, mRNA secondary structure stability (Delta G), and codon-pair bias (CPB), were analyzed to elucidate their influence on translational efficiency. While increased GC content enhanced mRNA stability in E. coli, A/T-rich codons in S. cerevisiae minimized secondary structure formation, and moderate GC content in CHO cells balanced mRNA stability and translation efficiency. Our findings highlight the limitations of single-metric approaches and advocate for a multi-criteria framework that integrates CAI, GC content, mRNA folding energy, and co don-pair considerations. This integrative strategy enables the design of tailored genetic sequences that meet host-specific requirements, advancing synthetic gene design for biotechnological innovation and precision biopharmaceutical applications. | Demissie, Eden A.; Park, Seo-Young; Moon, Je Hun; Lee, Dong-Yup | Sungkyunkwan Univ, Sch Chem Engn, Suwon 16419, South Korea; Kyungpook Natl Univ, Sch Med, Daegu 41944, South Korea | 59753310800; 57190490203; 57216946160; 35237858900 | dongyuplee@skku.edu; | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | J MICROBIOL BIOTECHN | 1017-7825 | 1738-8872 | 35 | SCIE | MICROBIOLOGY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 3.1 | 44.4 | 0 | 2025-05-07 | 0 | 0 | Codon optimization; synthetic biology; recombinant protein production; translational efficiency; host-specific expression | RNA SECONDARY STRUCTURE; ESCHERICHIA-COLI; DNA; EXPRESSION; USAGE; BIAS; IMMUNOGENICITY | Codon optimization; host-specific expression; recombinant protein production; synthetic biology; translational efficiency | Animals; Base Composition; CHO Cells; Codon; Codon Usage; Cricetulus; Escherichia coli; Genes, Synthetic; Protein Biosynthesis; Recombinant Proteins; RNA Stability; RNA, Messenger; Saccharomyces cerevisiae; Synthetic Biology; messenger RNA; recombinant protein; synthetic DNA; Article; biotechnology; CHO cell line; codon adaptation index; codon optimization; codon pair bias; codon usage; comparative study; Escherichia coli; gene expression; genetic parameters; genome-wide association study; microbial genetics; nonhuman; pharmaceutics; protein secondary structure; protein targeting; RNA folding; RNA stability; RNA translation; Saccharomyces cerevisiae; sequence analysis; synthetic biology; synthetic gene design; animal; chemistry; codon; codon usage; Cricetulus; DNA base composition; genetics; procedures; protein synthesis; synthetic biology | English | 2025 | 2025 | 10.4014/jmb.2411.11066 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Ferroptosis-Like Death Induction in Saccharomyces cerevisiae by Gold Nanoparticles | Ferroptosis, a novel form of regulated cell death (RCD), has emerged as a promising therapeutic strategy for cancer treatment. While gold nanoparticles (AuNPs) are known to induce cell death and ferroptosis in combination with certain antibiotics, the mechanisms underlying ferroptosis in microorganisms remain poorly understood. This study aimed to investigate whether AuNPs induce ferroptosis-like cell death in the eukaryotic microbe Saccharomyces cerevisiae. Our findings revealed that AuNPs significantly reduced cell viability in S. cerevisiae, suggesting their ability to trigger cell death. Ferroptosis-related precursors, including intracellular iron overload and depletion of glutathione (GSH), were observed, leading to the inactivation of glutathione peroxidase (GPx). These changes were associated with the accumulation of reactive oxygen species (ROS) and lipid peroxidation, which amplified oxidative stress within the cells. Elevated ROS levels and lipid peroxidation further resulted in membrane rupture and the formation of 8-hydroxydeoxyguanosine, indicating DNA damage. Mitochondrial dysfunction, a hallmark of ferroptosis, was also evident. AuNP treatment caused mitochondrial membrane potential hyperpolarization and a reduction in mitochondrial membrane density. Unlike previously characterized forms of RCD, ferroptosis-like death in S. cerevisiae did not involve chromatin condensation, DNA fragmentation, or metacaspase activation. Finally, ferroptosis-like characteristics were confirmed using Liperfluo, a lipid ROSspecific probe. In conclusion, this study demonstrated that AuNPs can induce ferroptosis-like cell death in S. cerevisiae. These findings highlight the potential of AuNPs as antifungal agents and contribute to the broader understanding of ferroptosis in eukaryotic microbes. | Kwun, Min Seok; Lee, Dong Gun | Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat Biores Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Life Sci & Biotechnol, Daegu 41566, South Korea | 57212491555; 55668060900 | dglee222@knu.ac.kr; | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | J MICROBIOL BIOTECHN | 1017-7825 | 1738-8872 | 35 | SCIE | MICROBIOLOGY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 3.1 | 44.4 | N/A | 0 | 0 | Ferroptosis-like death; gold nanoparticle; Saccharomyces cerevisiae; lipid peroxidation | OXIDATIVE STRESS; CELL-DEATH; MEDIATED GENERATION; LIPID-PEROXIDATION; GLUTATHIONE; APOPTOSIS; CASPASE; MITOCHONDRIA; SUPEROXIDE; MECHANISMS | Ferroptosis-like death; gold nanoparticle; lipid peroxidation; Saccharomyces cerevisiae | Cell Death; DNA Damage; Ferroptosis; Glutathione; Glutathione Peroxidase; Gold; Lipid Peroxidation; Membrane Potential, Mitochondrial; Metal Nanoparticles; Microbial Viability; Mitochondria; Oxidative Stress; Reactive Oxygen Species; Saccharomyces cerevisiae; 8 hydroxydeoxyguanosine; glutathione; glutathione peroxidase; gold nanoparticle; reactive oxygen metabolite; glutathione; glutathione peroxidase; gold; metal nanoparticle; reactive oxygen metabolite; Article; cell viability; cell viability assay; chromatin condensation; controlled study; depletion; disorders of mitochondrial functions; DNA damage; DNA fragmentation; enzyme activity; ferroptosis; fungal cell; fungal cell culture; fungal strain; iron overload; lipid peroxidation; membrane rupture; mitochondrial membrane potential; nonhuman; oxidative stress; Saccharomyces cerevisiae; cell death; chemistry; drug effect; metabolism; microbial viability; mitochondrion | English | 2025 | 2025 | 10.4014/jmb.2501.01029 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Folate Production by Streptococcus thermophilus IDCC 2201 and Its Impact on Human Gut Microbiota | Probiotics have been extensively investigated as potential food supplements for human health benefits. Metabolites derived from probiotics are the primary factors that characterize each strain's functionality and play a crucial role in shaping their effects on the human host. In this study, we characterized the secreted metabolite profiles of sixteen commercial probiotic strains and identified Streptococcus thermophilus IDCC 2201 as a major folate producer. To investigate its effects on gut microbiota, S. thermophilus was co-cultured with individual species comprising the human gut microbial community. Specific bacteria, such as Bacteroides thetaiotaomicron, Veilonella parvula, and Ruminococcus faecis, grew dependently on both folate and S. thermophilus. These bacteria exhibited greater growth in the presence of folate than in its absence, with 2.8-, 3.6-, and 3.9-fold increases, respectively. Additionally, they showed relatively higher growth when cocultured with S. thermophilus compared to other bacterial species, with 1.2-, 1.3-, and 1.9-fold increases, respectively. Our results indicate that the interaction between probiotics and the human gut microbiota can influence changes in ecological balance through nutrient cross-feeding, and understanding this interaction can be applied to precision probiotic therapies. | Nam, Eoun Ho; Lee, Minjee; Kim, Donggyu; Jung, Young Hoon; Yang, Jungwoo; Shin, Minhye | Inha Univ, Coll Med, Dept Microbiol, Incheon 22212, South Korea; Inha Univ, Program Biomed Sci & Engn, Incheon 22212, South Korea; Ildong Biosci, Pyeongtaek Si 17957, South Korea; Kyungpook Natl Univ, Food & Bioind Res Inst, Coll Agr & Life Sci, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Dongguk Univ, Coll Med, Dept Microbiol, Gyeongju 38066, South Korea | Jung, YoungHoon/LCE-3750-2024 | 58035371200; 57221979843; 58032283400; 55550063700; 56076383700; 57208401604 | db13jwy@dongguk.ac.kr; mhshin@inha.ac.kr; | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | J MICROBIOL BIOTECHN | 1017-7825 | 1738-8872 | 35 | SCIE | MICROBIOLOGY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 3.1 | 44.4 | 0 | 2025-06-11 | 0 | 0 | Probiotics; Streptococcus thermophilus; B vitamins; folate; gut microbial community | CHAIN FATTY-ACIDS; ONE-CARBON; METABOLISM; BACTERIA; HOST; BACTEROIDES; NUTRITION; DISEASE | B vitamins; folate; gut microbial community; Probiotics; Streptococcus thermophilus | Bacteria; Coculture Techniques; Folic Acid; Gastrointestinal Microbiome; Humans; Probiotics; Streptococcus thermophilus; folic acid; probiotic agent; short chain fatty acid; probiotic agent; Article; bacterial growth; bacterium culture; bacterium identification; Bacteroides thetaiotaomicron; coculture; comparative study; controlled study; drug manufacture; human; intestine flora; metabolic fingerprinting; metabolome; microbial community; nonhuman; Ruminococcus; Ruminococcus faecis; Streptococcus thermophilus; Veillonella parvula; bacterium; biosynthesis; classification; growth, development and aging; metabolism; Streptococcus thermophilus | English | 2025 | 2025 | 10.4014/jmb.2502.02045 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Inhibitory Effects of Compounds Isolated from Morinda citrifolia L. (Noni) Seeds against Particulate Matter-Induced Injury | Morinda citrifolia L. (noni) is native to the tropical and semitropical areas and has been commercially available in health food stores and chain grocery stores specializing in natural foods, recently. Noni seeds are discarded as waste products through the industrial production of noni juice even though their bioactivity components might be a potential source of functional foods. Not many studies of phytochemistry and biological activity have been investigated on noni seeds until now. In this study, the phytochemical investigation of M. citrifolia seeds led to the isolation of eight compounds (1-8) including four lignans (5-8). Their chemical structures were elucidated based on extensive spectroscopic analysis as well as the comparison with those reported in the literature. The isolated lignans were then evaluated for their anti-inflammatory activity by the 3-(4,5-dimethylthiazol-2-yl)2,5-diphynyltetrazolium bromide (MTT) assay in human bronchial epithelium BEAS-2B cells stimulated by 1-nitropyrene. As results, both four isolated lignans displayed high effects on the viability of BEAS-2B cells, indicating promising anti-inflammatory role in the airway disease. | Cao, Thao Quyen; Eom, Hyeongjin; Kim, Hyukjin; Kang, Ha Yeong; Park, Young Min; Jung, Sung Keun; Hahn, Dongyup | Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Integrat Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Tailored Food Technol, Daegu 41566, South Korea | Jung, SUNG KEUN/AGR-2623-2022; Quyen, Cao/AAP-9678-2020 | 56937820500; 58865595800; 59531064100; 57733176700; 59531064200; 35310491400; 36554163400 | skjung04@knu.ac.kr; dohahn@knu.ac.kr; | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | J MICROBIOL BIOTECHN | 1017-7825 | 1738-8872 | 35 | SCIE | MICROBIOLOGY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 3.1 | 44.4 | 0 | 2025-05-07 | 1 | 1 | Morinda citrifolia; noni; inflammation; particulate matter; lignans; BEAS-2B cells | CHEMICAL-CONSTITUENTS; FRUIT; LIGNANS; PROTEIN; HEALTH; CELLS; JUICE; ACID; OIL | BEAS-2B cells; inflammation; lignans; Morinda citrifolia; noni; particulate matter | Anti-Inflammatory Agents; Cell Line; Cell Survival; Epithelial Cells; Humans; Lignans; Morinda; Particulate Matter; Phytochemicals; Plant Extracts; Seeds; 1 nitropyrene; antiinflammatory agent; lignan; Morinda citrifolia extract; antiinflammatory agent; lignan; phytochemical; plant extract; antiinflammatory activity; antiproliferative activity; Article; BEAS-2B cell line; biological activity; cell viability; chemical structure; cytotoxicity test; human; human cell; isolation procedure; lung injury; Morinda citrifolia; MTT assay; nonhuman; particulate matter exposure; phytochemistry; spectroscopy; cell line; cell survival; chemistry; drug effect; epithelium cell; isolation and purification; Morinda; particulate matter; plant seed; toxicity | English | 2025 | 2025 | 10.4014/jmb.2407.07062 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Investigation of microbial contamination of commercial Romanowsky stain variant solutions used in veterinary clinics | Background: Diff-Quik (DQ) staining is widely used in clinical practice for its ease of use and rapid results. However, its potential contamination remains a concern. Hypothesis/Objectives: This study aimed to investigate DQ solution contamination in veterinary hospitals and identify factors affecting it through a questionnaire on stain usage practices. Materials and Methods: A survey was conducted to assess the use of DQ staining in local animal clinics. Samples of DQ solution II collected from each hospital participating in the survey were cultured and analysed microscopically for contamination. Results: A total of 67 DQ stain samples were collected from veterinary hospitals, of which 10 (14.92%) were found to be contaminated with pathogens. Bacterial cultures were positive in six of the samples (8.95%); four were contaminated with Staphylococcus pseudintermedius, one with Stenotrophomonas maltophilia and one with Bacillus haynesii. Malassezia pachydermatis was found in the remaining contaminated samples (n = 4, 5.97%). Statistical analysis revealed that the significant factors associated with DQ stain contamination were the use of a dropper, direct immersion of slides in the dye, average weekly usage and periodic replacement of the solution (p < 0.05). Conclusions and Clinical Relevance: This study confirms DQ solution contamination in general veterinary practice. To minimise contamination risk, using a dropper for stain application instead of direct specimen immersion in the stain is recommended. Furthermore, in hospitals where DQ solutions are frequently employed, the stain should be periodically replaced or examined under a microscope. © 2025 ESVD and ACVD. | Cho, Minji; Bae, Seulgi | Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, South Korea; Department of Veterinary Internal Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, South Korea | 59925385200; 59461572500 | sgbae@knu.ac.kr; | Veterinary Dermatology | VET DERMATOL | 0959-4493 | 1365-3164 | SCIE | DERMATOLOGY;VETERINARY SCIENCES | 2024 | 1.4 | 44.4 | 0 | 2025-06-11 | 0 | contamination; Diff-Quik staining; Malassezia; Staphylococcus; veterinary hospital | English | Article in press | 2025 | 10.1111/vde.13362 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | The Inhibitory Effects of Cordyceps militaris ARA301 Extract on LipopolysaccharideInduced Lung Injury in vivo | Lung injury is a critical health concern associated with severe inflammatory responses and tissue damage that can weaken respiratory function and potentially become life-threatening in severe cases. This study aimed to establish a mouse model of lung injury induced by lipopolysaccharides (LPS) derived from Klebsiella pneumoniae and to evaluate whether Cordyceps militaris ARA301 extract (CME) can prevent lung injury. CME was orally administered to mice for three consecutive days, followed by intranasal LPS administration. Mice were sacrificed 24 h later to analyze immune cell alterations and inflammatory responses through bronchoalveolar lavage fluid (BALF) and tissue analyses. CME administration inhibited immune cell infiltration, tissue fibrosis, and excessive mucus deposition induced by intranasal LPS administration. Furthermore, CME suppressed the expression of mucin 5AC (MUC5AC), a protein involved in mucus production, as well as the expression of inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) in lung tissues. In BALF, CME reduced the production of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor- alpha (TNF-alpha), and C-X-C motif chemokine ligand 1 (CXCL1), which were elevated due to LPS administration. Additionally, CME decreased the total immune cell, neutrophil, monocyte, and eosinophil numbers in BALF. The anti-inflammatory activity ofCME was evaluated in vitro using RAW 264.7 cells. CME treatment reduced the secretion of pro-inflammatory cytokines induced by LPS and inhibited the phosphorylation of p65, inhibitor of kappa B alpha (I kappa B alpha), and I kappa B kinase alpha (IKK alpha). These findings suggest that CME has potential as a functional health supplement effective in preventing lung injury. | Seong, Hye Kang; Kim, Min Jeong; Fauziah, Ardina Nur; Jeong, Hyeon Su; Kim, Hyo Jeong; Yang, Chung Yeol; Park, Su Jin; Bae, Soo Yeon; Jung, Sung Keun | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Bioara Co Ltd, Seoul 08375, South Korea; Kyungpook Natl Univ, Tailored Food Technol, Daegu 41566, South Korea | Jung, SUNG KEUN/AGR-2623-2022 | 59254751900; 57215818497; 59505841700; 59696162700; 59697455300; 59697455400; 58029038100; 59697024900; 35310491400 | skjung04@knu.ac.kr; | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | J MICROBIOL BIOTECHN | 1017-7825 | 1738-8872 | 35 | SCIE | MICROBIOLOGY;BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 3.1 | 44.4 | 0 | 2025-05-07 | 1 | 1 | Health functional food; respiratory health; Cordyceps militaris; ARA301; inflammation; bronchoalveolar lavage fluid | CELLS | ARA301; bronchoalveolar lavage fluid; Cordyceps militaris; Health functional food; inflammation; respiratory health | Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Cordyceps; Cytokines; Disease Models, Animal; Klebsiella pneumoniae; Lipopolysaccharides; Lung; Lung Injury; Male; Mice; Mice, Inbred BALB C; NF-kappa B; RAW 264.7 Cells; bacterium lipopolysaccharide; Cordyceps militaris ara301 extract; CXCL1 chemokine; cyclooxygenase 2; fungal extract; I kappa B kinase alpha; inducible nitric oxide synthase; interleukin 1beta; interleukin 6; mucin 5AC; phosphate buffered saline; transcription factor RelA; tumor necrosis factor; unclassified drug; antiinflammatory agent; cytokine; immunoglobulin enhancer binding protein; lipopolysaccharide; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; bronchoalveolar lavage fluid; cell count; cell infiltration; Cordyceps militaris; cytokine production; cytokine release; diet supplementation; drug dose comparison; drug efficacy; drug megadose; eosinophil count; histopathology; immunocompetent cell; in vitro study; in vivo study; inflammation; inhibition kinetics; Klebsiella pneumoniae; lipopolysaccharide-induced acute lung injury; low drug dose; lung parenchyma; male; monocyte count; mouse; mouse model; mucus secretion; multicenter study; neutrophil count; nonhuman; protein expression; protein phosphorylation; RAW 264.7 cell line; treatment duration; animal; Bagg albino mouse; bronchoalveolar lavage fluid; chemistry; Cordyceps; cytology; disease model; drug effect; drug therapy; lung; lung injury; metabolism; pathology; prevention and control | English | 2025 | 2025 | 10.4014/jmb.2412.12043 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Topical dexamethasone decelerates epithelial migration on the canine tympanic membrane | Background: Epithelial migration (EM) is integral to normal ear structure and function. Glucocorticoids are considered the first-line therapy for various external ear disorders; however, their effects on EM on the tympanic membrane (TM) and the external auditory canal (EAC) are understudied. Hypothesis/Objectives: To test the hypothesis that topical dexamethasone decelerates EM on the TM, this study aimed to evaluate the effects of topical dexamethasone on EM on the TMs of dogs. Animals: Seven ears of four healthy dogs. Materials and Methods: The migration distance of an ink drop deposited on the posterior quadrant of the pars tensa (TM EM rate) of dogs was calculated over 3 weeks from images captured with a video-otoscope. The results were compared by paired Student's t-test to those obtained from a subsequent experiment in which the same dogs were administered a fresh ink drop at the same position as previously (control group), yet additionally administered 0.1% dexamethasone (0.2 mL/ear) daily for the first 14 days (treatment group). Results: One of eight ears was excluded because of an anatomical problem. The TM EM rate of the remaining seven ears decreased by 46.74% in the treatment group compared with the control group (p < 0.05). Conclusions and Clinical Relevance: Topical dexamethasone decelerates EM on the TM of normal dogs' ears. In turn, it is extrapolated that debris removal from the EAC may be slowed, negatively impacting the EAC environment. Consequently, when dogs with otitis receive topical dexamethasone treatment, additional treatment, such as ear canal cleaning, may be required to minimise the effects of impaired TM EM. | Kim, Jihyun; Oh, Taeho; Bae, Seulgi | Kyungpook Natl Univ, Coll Vet Med, Dept Vet Internal Med, Daegu 41566, South Korea | 59861569000; 8251199600; 59461572500 | sgbae@knu.ac.kr; | VETERINARY DERMATOLOGY | VET DERMATOL | 0959-4493 | 1365-3164 | 36 | 2 | SCIE | DERMATOLOGY;VETERINARY SCIENCES | 2024 | 1.4 | 44.4 | 0 | 2025-05-07 | 0 | 0 | dexamethasone; dog; epithelial migration; glucocorticoid; tympanic membrane | GROWTH-FACTOR; PERFORATIONS; PHYSIOLOGY; ANATOMY | dexamethasone; dog; epithelial migration; glucocorticoid; tympanic membrane | Administration, Topical; Animals; Anti-Inflammatory Agents; Dexamethasone; Dog Diseases; Dogs; Female; Glucocorticoids; Male; Tympanic Membrane; alfaxalone; alfaxan; dexamethasone; glucocorticoid; medetomidine; antiinflammatory agent; dexamethasone; glucocorticoid; animal experiment; Article; Canis; controlled study; dog; eardrum; epithelial migration; male; migration; nonhuman; animal; dog disease; drug effect; drug therapy; female; topical drug administration | English | 2025 | 2025-04 | 10.1111/vde.13314 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Fabrication of Mastic Gum Resin Tethered Phospholipid Nanocarriers for the Evaluation and Enhancement of Anti-inflammatory and Anti-bacterial Effects | Introduction The objective of the present study was to improve the anti-inflammatory and antibacterial activities of mastic gum resin (MGR). MGR was loaded into a phospholipid nanocarrier with or without partially hydrolyzed ginsenoside, followed by dispersion into distilled water.Methods The phospholipid nanocarrier dispersion showed significantly enhanced in-vitro release, porcine skin/intestine permeation, and retention. When the ratio of the MGR versus partially hydrogenated ginsenoside reached 1:1 w/w in the nanocarrier composition, the in-vitro release increased 54.8-fold compared to the MGR powder suspended in the release media.Results Permeation of the nanocarrier dispersion through the porcine skin and intestine increased 160-fold and 42-fold, respectively, compared to permeation of the MGR powder suspension. Furthermore, the nanocarrier dispersion reduced NO production and iNOS mRNA expression in the LPS-stimulated RAW264.7 cells. MIC and MBC of the nanocarrier dispersion against P. gingivalis were 4.11 +/- 1.17 and 8.22 +/- 2.35 mu g/mL, respectively.Conclusion In conclusion, the anti-inflammatory and antibacterial activities of MGR were remarkably enhanced when the MGR was loaded into the nanocarrier with partially hydrolyzed ginsenoside. | Selvaraj, Karthikeyan; Lee, Sang-Jin; Song, Keun-Bae; Yoo, Bong-Kyu; Karuppaiah, Arjunan | Gachon Univ, Coll Pharm, 191 Hambakmoero, Incheon, South Korea; Sungkyunkwan Univ, Res Inst Aging Related Dis, Cooperat Ctr 85304, AniMusCure Inc, 2066 Seobu Ro, Gyeonggi Do 16149, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Prevent Dent, Daegu, South Korea; PSG Coll Pharm, Dept Pharmaceut, Coimbatore 600004, Tamil Nadu, India; INTI Int Univ, Fac Hlth & Life Sci, Persiaran Perdana Bbn, Nilai 71800, Negeri Sembilan, Malaysia | Karuppaiah, Dr Arjun/AAL-2615-2021 | 57395298400; 59896786400; 35105905200; 59896945800; 57211752280 | byoo@gachon.ac.kr; Dr.aj.mpharm.phd@gmail.com; | CURRENT PHARMACEUTICAL DESIGN | CURR PHARM DESIGN | 1381-6128 | 1873-4286 | 31 | 23 | SCIE | PHARMACOLOGY & PHARMACY | 2024 | 2.8 | 44.5 | 0 | 2025-06-11 | 0 | 0 | Anti-inflammation; anti-bacterial; lipid nanocarrier; mastic gum resin; ginsenoside; nanocarrier | BIOAVAILABILITY | anti-bacterial; Anti-inflammation; ginsenoside; lipid nanocarrier; mastic gum resin; nanocarrier | English | 2025 | 2025 | 10.2174/0113816128353794241225083428 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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