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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Neutron-γ discrimination with organic scintillator crystal: 9-Phenylcarbazole (9-PCz) grown by Bridgman - Stockbarger method | Organic scintillator crystal 9-Phenylcarbazole (9-PCz) has been grown using Bridgman-Stockbarger technique. The crystal structure, lattice parameter and bond angle values are measured from single-crystal X-ray diffraction (SXRD) analysis. C-H inplane bending and out of plane bending and skeletal vibrations of 9-PCz molecule were identified from vibrational spectral analysis. UV-visible NIR spectral study shows that the crystal exhibits around 50% of transmittance in the infrared region and the direct optical bandgap energy is calculated to be 3.36 eV. Thermal properties of grown 9-PCz material were measured using thermogravimetric and differential thermal analyses (TG-DTA). The photoluminescence (PL) measurements show two emission bands with a maximum peak at 365 nm and a shoulder peak at 381 nm. X-ray induced luminescence spectrum of 9-PCz crystal exhibits a maximum emission peak at 381 nm. Scintillation decay time measurement shows the major component of 18 ns decay time. The pulse shape discrimination (PSD) capability of the grown crystal sample was studied for the signals induced by alpha-particles and gamma-rays from Am-241 and Cs-137 sources, respectively. The figure of merit (FOM) is found to be 2.69. The preliminary results showed that the present studied organic crystal (9-PCz) scintillator can be considered in the field of fast neutron detection application. | Ramachandran, K.; Raja, A.; Phan, Q., V; Daniel, D. Joseph; Kim, H. J.; Pandian, Muthu Senthil; Ramasamy, P. | Sri Sivasubramaniya Nadar Coll Engn, SSN Res Ctr, Chennai 603110, Tamil Nadu, India; Univ Salerno, CNR SPIN, I-84084 Salerno, Italy; Kyungpook Natl Univ, Ctr High Energy Phys, Daegu 41566, South Korea | ramachandran, krithikadevi/ABC-3128-2020; Ramasamy, Prakash/AGT-2329-2022; Pandian, Senthil/JZE-1955-2024; Raja, Arumugam/Q-1781-2019; Kim, Hong Joo/AAE-1178-2022 | 58647715500; 57189505213; 57202820686; 55235066800; 59051568100; 58702968600; 36014318600 | joseph@knu.ac.kr;senthilpandianm@ssn.edu.in; | OPTICAL MATERIALS | OPT MATER | 0925-3467 | 1873-1252 | 126 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;OPTICS | 2022 | 3.9 | 27.5 | 0.29 | 2025-06-25 | 3 | 3 | Crystal growth; Organic; Scintillator; Decay time | BENZIMIDAZOLE SINGLE-CRYSTALS | Crystal growth; Decay time; Organic; Scintillator | Crystal growth; Crystal structure; Gamma rays; Luminescence; Scintillation counters; Single crystals; Spectroscopic analysis; Spectrum analysis; Vibration analysis; Bond angle; Bridgman-Stockbarger method; Bridgman-Stockbarger Techniques; Crystals structures; Decay time; Organic scintillator; Organics; Scintillator; Scintillator crystals; Single crystal X-ray diffraction analysis; Differential thermal analysis | English | 2022 | 2022-04 | 10.1016/j.optmat.2022.112242 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Organic Light-Dependent Resistors with Near Infrared Light-Absorbing Conjugated Polymer Films | Here we demonstrate near-infrared (NIR) light-sensing organic light-dependent resistors (OLDRs), so-called organic photoresistors (OPRTs), which consist of solution-processed NIR light-absorbing films of poly[{2,5-bis(2-octyldodecyl)-3,6-bis(thien-2-yl)-pyrrolo[3,4-c]pyrrole- 1,4-diyl}-co-{2,2'-(2,1,3-benzothiadiazole)-5,5'-diyl}] (PODTPPD-BT). The present NIR-OPTRs were fabricated in a planar geometry by forming two aluminum electrodes in parallel on the PODTPPD-BT films with three different thicknesses (40, 100, and 160 nm). The sensing characteristics of NIR-OLDRs were examined using a NIR laser diode featuring a wavelength (lambda) of lambda = 905 nm that is one of the popular wavelengths employed for light detection and ranging (LiDAR) systems. In the dark condition, the electrical resistance (R-H) of devices in the horizonal direction was marginally changed with the thickness of PODTPPD-BT films. However, the R-H values were remarkably reduced upon the NIR light illumination for all devices and were strongly dependent on the NIR light intensity. Thermal annealing of devices delivered greatly improved current responses leading to a huge R-H reduction (by ca. 80%) and excellent sensing stability, even though only 49% improvement in R-H was achieved by thermal annealing of films. | Kim, Taehoon; Lee, Chulyeon; Lee, Woongki; Kim, Hwajeong; Kim, Youngkyoo | Kyungpook Natl Univ, KNU Inst Nanophoton Applicat KINPA, Organ Nanoelect Lab, Dept Chem Engn,Sch Appl Chem Engn, Daegu 41566, South Korea | 57218650958; 56354831300; 59041346100; 15520531700; 10340424400 | ykimm@knu.ac.kr; | ACS APPLIED ELECTRONIC MATERIALS | ACS APPL ELECTRON MA | 2637-6113 | 4 | 1 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2022 | 4.7 | 27.5 | 0.89 | 2025-06-25 | 12 | 11 | organic light-dependent resistors; photoresistors; near infrared; conjugated polymers; electrical resistance | HIGH-PERFORMANCE; CADMIUM SELENIDE; PHOTODETECTORS; PHOTOSENSITIVITY; FABRICATION; ULTRAVIOLET; INTERFACE; ARRAYS; LAYER; CDS | conjugated polymers; electrical resistance; near infrared; organic light-dependent resistors; photoresistors | Electric resistance; Geometry; Infrared devices; Optical radar; Polymer films; Resistors; Electrical resistances; Light sensing; Light-dependent resistors; Near Infrared; Near infrared light; Near-infrared; Organic light-dependent resistor; Organics; Solution-processed; Thermal-annealing; Conjugated polymers | English | 2022 | 2022-01-25 | 10.1021/acsaelm.1c00810 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Preparation of PVA/CMC/PVP blended polymer loaded with ZnS1-xCux; investigation of structural and linear/nonlinear optical properties | Nonstoichiometric ZnS1-xCux powders have been loaded to 0.5PVA/0.25CMC/0.25PVP blended polymers using casting method. X-ray diffraction Rietveld analysis was performed for accurate quantification and structural parameters determination of the phases developed in the ZnS1-xCux nanofiller for different content of Cu (x). The surface morphology and chemical composition of the formed polymer blends were investigated using SEM and EDS analysis. The influence of loading the nanofiller with different (x) on the linear and nonlinear optical properties was explored utilizing the UV-vis diffuse reflectance. The variation in the absorption, transmittance, refractive index, extinction coefficient, dielectric constant, energy loss functions, the refractive index dispersion and optical conductivity of the obtained composites was tracked. The determined direct and indirect optical band gap energies of the unloaded blend are 5.16 and 4.92 eV, respectively, which were reduced nonlinearly attaining the lowest values (4.71, 3.5) eV for x = 0.1. The variation in the intensity of fluorescence (FL) and the colors emitted was investigated applying two excitation wavelengths, 317 and 380 nm. | El-naggar, A. M.; Heiba, Zein. K.; Kamal, A. M.; Lakshminarayana, G.; Abd-Elkader, Omar. H.; Mohamed, Mohamed. Bakr | King Saud Univ, Coll Sci, Phys & Astron Dept, POB 2455, Riyadh 11451, Saudi Arabia; Ain Shams Univ, Fac Sci, Phys Dept, Cairo, Egypt; Kyungpook Natl Univ, Intelligent Construct Automat Ctr, 80 Daehak Ro, Daegu 41566, South Korea; King Saud Univ, Coll Sci, Res Chair Exploitat Renewable Energy Applicat Saud, Phys & Astron Dept, POB 2455, Riyadh 11451, Saudi Arabia | Mohamed, Mohamed Bakr/P-2194-2014; El-Naggar, Ahmed/H-9098-2018; Abd Elkader, omar/J-1804-2015; Abd Elkader, Omar/AAQ-2892-2020; Mohamed, Mohamed/P-2194-2014 | 7201947258; 6602591867; 36719759500; 57194637883; 57192277362; 37018029400 | zein_kh@yahoo.com;mbm1977@yahoo.com; | OPTICAL MATERIALS | OPT MATER | 0925-3467 | 1873-1252 | 133 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;OPTICS | 2022 | 3.9 | 27.5 | 1.82 | 2025-06-25 | 19 | 19 | PVA; CMC; PVP; Nano ZnS 1-x Cu x; Structure; Linear and nonlinear optical | X-RAY-DIFFRACTION; ELECTRICAL-PROPERTIES; POLY(VINYL ALCOHOL); BEHAVIOR; CRYSTALLIZATION | Linear and nonlinear optical; Nano ZnS<sub>1-x</sub>Cu<sub>x</sub>; PVA/CMC/PVP; Structure | Chemical analysis; Energy dissipation; Energy gap; Morphology; Nonlinear optics; Polymer blends; Refractive index; Rietveld analysis; Surface morphology; Blended polymers; Casting method; Linear optical; Nano ZnS1-xcux; Nanofiller; Non-linear optical; Nonlinear optical properties; Nonstoichiometric; PVA/CMC/PVP; X- ray diffractions; Blending | English | 2022 | 2022-11 | 10.1016/j.optmat.2022.113066 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Synthesis and elemental analysis of gadolinium halides (GdX3) in glass matrix for radiation detection applications | Numerous researchers were intrigued to glasses for radiation detection and scintillation applications in nuclear and high-energy physics research. To mitigate the requirements of density and luminescence enhancement, gadolinium (Gd) compounds are widely practiced. Gd halides (GdX3) are hygroscopic salts that can function as excellent sensitizers in a glass network to improve activator (Ce) luminescence. To ensure the elemental abundance of the constituents in glass samples after high temperature combustion, EDX reports at both the intermediate and final phases of the glass samples can be useful. However, EDX analysis was unable to detect halogens in glass substances in their intermediate and final forms. The implications were examined on the basis of prior literature indicating the feasibility of high temperature combustion in an air environment. Nevertheless, it was discovered that transmittance spectra are essential for the performance of radioluminescence and scintillation features. Two samples that were previously enriched with GdI3 had transmittance values more than 55% at the X-ray generated emission peak point. alpha-peaks with an energy resolution (FWHM) of 29% and 31% were obtained utilizing these samples. The scintillation decay projections from these two samples were fitted with three exponential decay components, with the shortest components being 30.6 ns and 29.5 ns, contributing 38% and 37.4%, respectively. | Saha, Sudipta; Ntarisa, Amos V.; Quang, Nguyen Duy; Kim, H. J.; Kothan, S.; Kaewkhao, J. | Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Chiang Mai Univ, Fac Associated Med Sci, Ctr Radiat Res & Med Imaging, Dept Radiol Technol, Chiang Mai 50200, Thailand; Nakhon Pathom Rajabhat Univ, Fac Sci & Technol, Phys Program, Nakhon Pathom 73000, Thailand; Nakhon Pathom Rajabhat Univ, Ctr Excellence Glass Technol & Mat Sci CEGM, Nakhon Pathom 73000, Thailand | Kim, Hong Joo/AAE-1178-2022; Ntarisa, Amos/JWO-6086-2024; Ntarisa, Amos Vincent/JWO-6086-2024 | 55935496600; 57160289700; 57223004024; 59051568100; 6507017165; 23974520300 | hongjoo@knu.ac.kr; | OPTICAL MATERIALS | OPT MATER | 0925-3467 | 1873-1252 | 129 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;OPTICS | 2022 | 3.9 | 27.5 | 0.57 | 2025-06-25 | 5 | 6 | Gadolinium halide; Energy dispersive X-ray spectroscopy (EDX); Transmittance; Scintillation; Decay-time | EARTH-METAL CHLORIDES; OPTICAL BASICITY; ENERGY-TRANSFER; LUMINESCENCE; WATER | Decay-time; Energy dispersive X-ray spectroscopy (EDX); Gadolinium halide; Scintillation; Transmittance | Combustion; Energy dispersive spectroscopy; Glass; High energy physics; Scintillation; Decay time; Energy dispersive X ray spectroscopy; Energy dispersive X-ray spectroscopy; Gadolinia; Gadolinia halide; Glass matrices; Glass samples; High-temperature combustion; Radiation detection; Transmittance; Gadolinium compounds | English | 2022 | 2022-07 | 10.1016/j.optmat.2022.112490 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Correction | The effect of concentration of nano CdS/Fe prepared under different conditions on the structural, optical absorption and linear/nonlinear parameters of PVA/PVP polymer blend (vol 122, 111788, 2022) | Heiba, Zein K.; El-naggar, A. M.; Mohamed, Mohamed Bakr; Kamal, A. M.; Osman, M. M.; Albassam, A. A.; Lakshminarayana, G. | Ain Shams Univ, Fac Sci, Phys Dept, Cairo, Egypt; King Saud Univ, Coll Sci, Phys & Astron Dept, POB 2455, Riyadh 11451, Saudi Arabia; Kyungpook Natl Univ, Intelligent Construct Automat Ctr, 80 Daehak Ro, Daegu 41566, South Korea | Mohamed, Mohamed/P-2194-2014; El-Naggar, Ahmed/H-9098-2018; Osman, Muhammad/ABB-1026-2021 | 6602591867; 7201947258; 37018029400; 36719759500; 57225724020; 59823186100; 57194637883 | mbm1977@yahoo.com; | OPTICAL MATERIALS | OPT MATER | 0925-3467 | 1873-1252 | 134 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;OPTICS | 2022 | 3.9 | 27.5 | 2.39 | 2025-06-25 | 0 | 1 | English | 2022 | 2022-12 | 10.1016/j.optmat.2022.113207 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | Article | Tunable Magnetism and Morphology of Ferromagnetic Nanocups in Perovskite Ferroelectric Films via Co Exsolution of Transition Metals | In complex oxides, delicate tuning of the dimension, scale, shape, and stability of nanostructures is essential to obtain the emergent properties, which are not commonly attained when using the typical thin film growth process. Herein, we demonstrate that the exsolution process, which is modulated by simple doping control, is an efficient method to achieve tunable magnetism and the morphology of nanocups in perovskite ferroelectric Bi3.25La0.75Ti3O12 (BLT) thin films. The multimodal structural and magnetic analyses verify that the codoping of Co and Fe reinforces the phase-separated unique nanocup formation, which is revealed to be a CoFe2O4 spinel ferrimagnet. By employing density functional theory calculations, we show that different doping combinations change the relative exsolution energies of Co and Fe, which may result in the selective formation of nanocup structures. Our study presents a simple and effective methodology for the engineering of nanostructure and multifunctionality in nanocomposite films. © 2022 American Chemical Society. | An, Hyunji; Kim, Jeong-Kyu; Jung, Soon-Gil; Kim, Sangmo; Na, Kyeongho; Yang, Jiwoong; Song, Jaesun; Park, Tuson; Bark, Chung Wung; Kim, Sooran; Ko, Kyung-Tae; Kim, Bongjae; Lee, Sanghan | School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea; Max Planck POSTECH, Hsinchu Center for Complex Phase Materials, Department of Physics, Pohang University of Science and Technology, Pohang, 37673, South Korea; Center for Quantum Materials and Superconductivity (CQMS), Department of Physics, Sungkyunkwan University, Suwon, 16419, South Korea; School of Intelligent Mechatronics Engineering, Sejong University, Seoul, 05006, South Korea; School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea; School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea; School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea; Center for Quantum Materials and Superconductivity (CQMS), Department of Physics, Sungkyunkwan University, Suwon, 16419, South Korea; Department of Electrical Engineering, Gachon University, Seongnam, 13120, South Korea; Department of Physics Education, Kyungpook National University, Daegu, 41566, South Korea; Research Center for Materials Analysis, Korea Basic Science Institute, Daejeon, 34133, South Korea; Department of Physics, Kunsan National University, Gunsan, 54151, South Korea; School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, South Korea | 57189868807; 57219918202; 15128724200; 8928068500; 57780152200; 57222997555; 57189876123; 8251575700; 8316177200; 55146733200; 26026021900; 55650566000; 55716521500 | sanghan@gist.ac.kr;bongjae.kim@kunsan.ac.kr; | ACS Applied Electronic Materials | ACS APPL ELECTRON MA | N/A | 2637-6113 | 4 | 9 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2022 | 4.7 | 27.5 | 0.08 | 2025-06-25 | 1 | exsolution; multiferroic; nanocomposite film; perovskite oxides; tunable magnetism | Bismuth compounds; Cobalt; Density functional theory; Ferroelectric films; Ferroelectricity; Film growth; Iron compounds; Lanthanum compounds; Magnetism; Morphology; Nanocomposite films; Nanocomposites; Nanostructures; Perovskite solar cells; Semiconductor doping; Thin films; Complex oxides; Emergent property; Exsolution; Ferromagnetics; Multiferroics; Perovskite oxides; Simple++; Thin films growth; Tunable magnetism; Tunables; Perovskite | English | Final | 2022 | 10.1021/acsaelm.2c00738 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Persistent serotype 3 and 19A invasive pneumococcal diseases in adults in vaccine era: Serotype-dependent difference in ceftriaxone susceptibility | Background: Invasive pneumococcal disease (IPD) is associated with substantial morbidity and mortality in children and elderly populations. Serotype distribution and antibiotic susceptibility of IPD isolates are changing with the implementation of pneumococcal vaccination and increasing antibiotic use worldwide. We aimed to determine serotype distribution, antibiogram, and molecular epidemiology of pneumococci in the late stage of PCV13 era. Methods: Prospective multicenter IPD surveillance study was conducted for adults aged >= 19 years from July 2019 to June 2021. Clinical and epidemiologic data were collected. In addition, antibiotic susceptibility test, serotype identification and multi-locus sequence typing (MLST) was taken for pneumococcal isolates. Results: A total of 160 IPD cases were collected with mean age of 65.1 years (male, 72.5%). Serotyping was taken for 116 available pneumococcal isolates. PCV13 and PPSV23 serotypes were 32.8% (n = 38) and 56.0% (n = 65), respectively. Serotype 3 (13.8%) and 19A (9.5%) were the most common causative agents of IPD, followed by serogroup 11 (6.9%), 23A (6.9%), 10A (4.3%), and 15B (4.3%). Notably, 32.5% of invasive pneumococcal isolates were non-susceptible to ceftriaxone. Serotypes 11A, 11E and 19A pneumococci showed high ceftriaxone non-susceptible rate (80%, 100% and 81.8% respectively), and they were related to sequence type (ST) 166 and ST320. In comparison, most serotype 3 isolates were ceftriaxone susceptible and related to ST180. Conclusions: PCV serotypes, especially 3 and 19A, are still prevalent in adult IPDs, suggesting that individual PCV13 immunization would be necessary for the elderly people and chronically ill patients. Ceftriaxone non-susceptible rate was remarkably high in invasive pneumococcal isolates. (C) 2022 Elsevier Ltd. All rights reserved. | Yoon, Jin Gu; Jang, A-Yeung; Kim, Min Ja; Bin Seo, Yu; Lee, Jacob; Choi, Young Hwa; Kim, Young Keun; Jeong, Eun Joo; Kim, Hyun Soo; Kwon, Ki Tae; Jung, Dong Sik; Choi, Won Suk; Lee, Jin Soo; Park, Kyung Hwa; Jeong, Hye Won; Baik, Seung Hee; Kang, Seong Hui; Bae, In-Gyu; Noh, Ji Yun; Cheong, Hee Jin; Kim, Woo Joo; Song, Joon Young | Korea Univ, Guro Hosp, Dept Internal Med, Div Infect Dis,Coll Med, 148 Gurodong Ro, Seoul 08308, South Korea; Korea Univ, Anam Hosp, Dept Internal Med, Div Infect Dis,Coll Med, Seoul, South Korea; Hallym Univ, Kangnam Sacred Heart Hosp, Dept Internal Med, Div Infect Dis,Coll Med, Seoul, South Korea; Ajou Univ, Dept Infect Dis, Sch Med, Suwon, South Korea; Yonsei Univ, Dept Internal Med, Div Infect Dis, Wonju Coll Med, Wonju, South Korea; Hallym Univ, Coll Med, Dept Internal Med, Div Infect Dis,Dongtan Sacred Heart Hosp, Hwaseong, South Korea; Hallym Univ, Coll Med, Dept Lab Med, Dongtan Sacred Heart Hosp, Hwaseong, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Dong A Univ, Div Infect Dis, Dept Internal Med, Coll Med, Busan, South Korea; Korea Univ, Ansan Hosp, Dept Internal Med, Div Infect Dis,Coll Med, Ansan, South Korea; Inha Univ, Dept Internal Med, Div Infect Dis, Coll Med, Incheon, South Korea; Chonnam Natl Univ Med Sch, Dept Internal Med, Div Infect Dis, Gwangju, South Korea; Chungbuk Natl Univ, Dept Internal Med, Div Infect Dis, Coll Med, Cheongju, South Korea; Cheju Halla Gen Hosp, Dept Internal Med, Div Infect Dis, Jeju, South Korea; Konyang Univ Hosp, Dept Internal Med, Div Infect Dis, Daejeon, South Korea; Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Dept Internal Med, Coll Med, Jinju, South Korea | Jeong, Hye/AET-1982-2022; Hwang, Soyoon/HHM-5762-2022; Kim, Seunghyun/AAA-3402-2022; Kim, Woo/D-2733-2015; Choi, Won Suk/V-2730-2017; Kim, Ji Hwan/JKJ-3785-2023; Choi, Won/V-2730-2017; A-yeung, Jang/HLG-4767-2023; Kim, Young/H-4235-2013; Kim, Hyunho/GQH-5608-2022; Jung, Dong Sik/HOH-5826-2023 | 57104165700; 57210289600; 57221707888; 18538511000; 13406664300; 27167708700; 35322538300; 57189642478; 58105873600; 9733850500; 14023089600; 56718971800; 56162297100; 57219637574; 13103042700; 57220658376; 57547373500; 7004882611; 24587375200; 7102495865; 27171770800; 57214400146 | infection@korea.ac.kr; | VACCINE | VACCINE | 0264-410X | 1873-2518 | 40 | 15 | SCIE | IMMUNOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2022 | 5.5 | 27.6 | 1.08 | 2025-06-25 | 9 | 8 | Pneumococcal Infections; Serotype; Pneumococcal Vaccines; Multi-locus Sequence Typing | RESISTANT STREPTOCOCCUS-PNEUMONIAE; CONJUGATE VACCINE; BURDEN; EPIDEMIOLOGY; CHILDREN; 11A | Multi-locus Sequence Typing; Pneumococcal Infections; Pneumococcal Vaccines; Serotype | Adult; Aged; Ceftriaxone; Child; Humans; Infant; Male; Multilocus Sequence Typing; Pneumococcal Infections; Pneumococcal Vaccines; Prospective Studies; Serogroup; Serotyping; Young Adult; ceftriaxone; Pneumococcus vaccine; ceftriaxone; Pneumococcus vaccine; adult; aged; antibiotic sensitivity; Article; bacterial strain; bacterium isolate; chronic disease; controlled study; disease surveillance; epidemiological data; female; human; immunization; major clinical study; male; middle aged; minimum inhibitory concentration; molecular epidemiology; multicenter study; multilocus sequence typing; nonhuman; patient information; pneumococcal infection; prospective study; serotype; Streptococcus pneumoniae; very elderly; young adult; child; clinical trial; infant; pneumococcal infection; serotype; serotyping | English | 2022 | 2022-04-01 | 10.1016/j.vaccine.2022.03.004 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Volume of parapharyngeal fat pad in obstructive sleep apnea syndrome: prognostic role for multilevel sleep surgery | Study Objectives: To evaluate the prognostic role of volume of parapharyngeal fat pad (VPPFP) after multilevel sleep surgery in patients with obstructive sleep apnea syndrome.Methods: This retrospective cohort study was conducted in 50 patients with moderate to severe obstructive sleep apnea syndrome who underwent polysomnography (preoperative and postoperative 6 months) and preoperative facial computed tomography with multilevel sleep surgery between May 2010 and February 2019. All patients had failed or refused positive airway pressure treatment. Results: Of the 50 patients with moderate to severe obstructive sleep apnea syndrome who underwent multilevel sleep surgery, 46 were male (92.0%) with mean & PLUSMN; standard deviation age of 41.2 & PLUSMN; 12.5 years. On the preoperative polysomnography, mean & PLUSMN; standard deviation of apnea-hypopnea index and CT90 (cumulative percentage of time spent at oxygen saturation less than 90%) were 43.4 & PLUSMN; 19.3 events/h and 5.6 & PLUSMN; 9.6%, respectively. The average VPPFP measured by facial computed tomography scan was 4.9 & PLUSMN; 1.9 cm3. Multiple linear regression analysis showed that VPPFP was significantly correlated (R2 = 0.38) with age (b = 0.05; 95% confidence interval [CI], 0.01-0.09) and body mass index (b = 0.31; 95% CI, 0.16-0.45). Surgical success rate was 38%, and VPPFP higher than 5.1 cm3 was significantly associated with surgical failure after covariate adjustment (P = .01; odds ratio = 0.09; 95% CI, 0.02-0.48). Postoperative apnea-hypopnea index was positively correlated (R2 = 0.40) with CT90 (b = 1.33; 95% CI, 0.74-1.92) and VPPFP (b = 3.52; 95% CI, 0.30-6.74).Conclusions: VPPFP correlated with age and body mass index, and high VPPFP and CT90 were associated with high postoperative apnea-hypopnea index. VPPFP larger than 5.1 cm3 was a possible risk factor for surgical failure, which may inform a decision on multilevel sleep surgery as salvage therapy for positive airway pressure treatment. | Kim, Byung Kil; Park, Song I.; Hong, Sang Duk; Jung, Yong Gi; Kim, Hyo Yeol | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Daegu, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Sch Med, 81 Irwon ro, Seoul 06351, South Korea | Kim, Hyo Yeol/HLP-5150-2023 | 57469397400; 57202418734; 24072844200; 23025412600; 7410127775 | ent.jyg@gmail.com;siamkhy@gmail.com; | JOURNAL OF CLINICAL SLEEP MEDICINE | J CLIN SLEEP MED | 1550-9389 | 1550-9397 | 18 | 12 | SCIE | CLINICAL NEUROLOGY | 2022 | 4.3 | 27.6 | 0 | 2025-06-25 | 0 | 0 | sleep apnea; obstructive; parapharyngeal space; adipose tissue; prognosis; surgical procedures; operative | UPPER AIRWAY STIMULATION; UVULOPALATOPHARYNGOPLASTY SUCCESS; TISSUE DISTRIBUTION; PATIENT SELECTION; RISK-FACTORS; OBESITY; IMPACT; ADULTS; PATHOGENESIS; ENDOSCOPY | adipose tissue; obstructive; operative; parapharyngeal space; prognosis; sleep apnea; surgical procedures | Adipose Tissue; Adult; Female; Humans; Male; Middle Aged; Prognosis; Retrospective Studies; Sleep; Sleep Apnea, Obstructive; adipose tissue; adult; complication; female; human; male; middle aged; prognosis; retrospective study; sleep; sleep disordered breathing | English | 2022 | 2022-12-01 | 10.5664/jcsm.10230 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Accelerated Synthetic MRI with Deep Learning-Based Reconstruction for Pediatric Neuroimaging | BACKGROUND AND PURPOSE: Synthetic MR imaging is a time-efficient technique. However, its rather long scan time can be challenging for children. This study aimed to evaluate the clinical feasibility of accelerated synthetic MR imaging with deep learning-based reconstruction in pediatric neuroimaging and to investigate the impact of deep learning-based reconstruction on image quality and quantitative values in synthetic MR imaging. MATERIALS AND METHODS: This study included 47 children 2.3-14.7 years of age who underwent both standard and accelerated synthetic MR imaging at 3T. The accelerated synthetic MR imaging was reconstructed using a deep learning pipeline. The image quality, lesion detectability, tissue values, and brain volumetry were compared among accelerated deep learning and accelerated and standard synthetic data sets. RESULTS: The use of deep learning-based reconstruction in the accelerated synthetic scans significantly improved image quality for all contrast weightings (P .05). The tissue values and brain tissue volumes obtained with accelerated deep learning and the other 2 scans showed excellent agreement and a strong linear relationship (all, R-2 > 0.9). The difference in quantitative values of accelerated scans versus accelerated deep learning scans was very small (tissue values, < 0.5%; volumetry, -1.46%-0.83%). CONCLUSIONS: The use of deep learning-based reconstruction in synthetic MR imaging can reduce scan time by 42% while maintaining image quality and lesion detectability and providing consistent quantitative values. The accelerated deep learning synthetic MR imaging can replace standard synthetic MR imaging in both contrast-weighted and quantitative imaging. | Kim, E.; Cho, H. -H.; Cho, S. H.; Park, B.; Hong, J.; Shin, K. M.; Hwang, M. J.; You, S. K.; Lee, S. M. | Kyungpook Natl Univ, Sch Med, Dept Med & Biol Engn, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea; Korea Inst Radiol & Med Sci, Korea Radioisotope Ctr Pharmaceut, Seoul, South Korea; Ewha Womans Univ, Coll Med, Dept Radiol, Seoul, South Korea; Ewha Womans Univ, Med Res Inst, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Radiol, Daegu, South Korea; GE Healthcare Korea, Seoul, South Korea; Chungnam Natl Univ, Chungnam Natl Univ Hosp, Coll Med, Dept Radiol, Daejeon, South Korea; Kyungpook Natl Univ, Dept Radiol, Chilgok Hosp, 807 Hoguk Ro, Daegu 41404, South Korea | 57215273419; 56544900900; 55686242700; 57211532915; 57215858314; 7402410737; 57200114449; 56710939300; 56824903400 | amour7230@knu.ac.kr; | AMERICAN JOURNAL OF NEURORADIOLOGY | AM J NEURORADIOL | 0195-6108 | 1936-959X | 43 | 11 | SCIE | CLINICAL NEUROLOGY;NEUROIMAGING;RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2022 | 3.5 | 27.8 | 2.05 | 2025-06-25 | 22 | 18 | BRAIN | Brain; Child; Deep Learning; Humans; Magnetic Resonance Imaging; Neuroimaging; adolescent; article; brain tissue; child; clinical article; controlled study; deep learning; feasibility study; female; human; image quality; male; neuroimaging; nuclear magnetic resonance imaging; pipeline; quantitative analysis; volumetry; brain; diagnostic imaging; neuroimaging; nuclear magnetic resonance imaging; pathology; procedures | English | 2022 | 2022-11 | 10.3174/ajnr.a7664 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Accumulation patterns of intracellular salts in a new halophilic amoeboflagellate, Euplaesiobystra salpumilio sp. nov., (Heterolobosea; Discoba) under hypersaline conditions | Halophilic microbial eukaryotes are present in many eukaryotic lineages and major groups; however, our knowledge of their diversity is still limited. Furthermore, almost nothing is known about the intracellular accumulation of salts in most halophilic eukaryotes. Here, we isolate a novel halophilic microbial eukaryote from hypersaline water of 134 practical salinity units (PSU) in a solar saltern. This species is an amoeboflagellate (capable of the amoeba-flagellate-cyst transformation) in the heterolobosean group and belongs to the genus Euplaesiobystra based on morphological data and 18S rDNA sequences. However, the isolate is distinct from any of the described Euplaesiobystra species. Especially, it is the smallest Euplaesiobystra to date, has a distinct cytostome, and grows optimally at 75-100 PSU. Furthermore, the phylogenetic tree of the 18S rDNA sequences demonstrates that the isolate forms a strongly supported group, sister to Euplaesiobystra hypersalinica. Thus, we propose that the isolate, Euplaesiobystra salpumilio, is a novel species. E. salpumilio displays a significantly increased influx of the intracellular Na+ and K+ at 50, 100, and 150 PSU, compared to freshwater species. However, the intracellular retention of the Na+ and K+ at 150 PSU does not significantly differ from 100 PSU, suggesting that E. salpumilio can extrude the Na+ and K+ from cells under high-salinity conditions. Interestingly, actively growing E. salpumilio at 100 and 150 PSU may require more intracellular accumulation of Na+ than the no-growth but-viable state at 50 PSU. It seems that our isolate displays two salt metabolisms depending on the tested salinities. E. salpumilio shows a salt-in strategy for Na+ at lower salinity of 100 PSU, while it displays a salt-out strategy for Na+ at higher salinity of 150 PSU. Our results suggest that the novel halophilic E. salpumilio fundamentally uses a salt-out strategy at higher salinities, and the accumulation patterns of intracellular salts in this species are different from those in other halophilic microbial eukaryotes. | Lee, Hyeon Been; Jeong, Dong Hyuk; Park, Jong Soo | Kyungpook Natl Univ, Dept Oceanog, Daegu, South Korea | Park, Jong/AAJ-3576-2020 | 57337671100; 57338712200; 23486274100 | jongsoopark@knu.ac.kr; | FRONTIERS IN MICROBIOLOGY | FRONT MICROBIOL | 1664-302X | 13 | SCIE | MICROBIOLOGY | 2022 | 5.2 | 27.8 | 0.39 | 2025-06-25 | 4 | 4 | halophile; Heterolobosea; hypersaline; intracellular salt; osmoregulation; protozoa | N. SP.; MOLECULAR SYSTEMATICS; HALOTOLERANT; EVOLUTIONARY; MORPHOLOGY; AMEBA; DIVERSITY; STRATEGY; LINEAGE; FUNGUS | halophile; Heterolobosea; hypersaline; intracellular salt; osmoregulation; protozoa | DNA 18S; potassium; sodium; sodium ion; amoeba (life cycle stage); Article; controlled study; DNA extraction; Euplaesiobystra salpumilio; flagellate; freshwater species; halophile; Heterolobosea; killer cell; metabolism; nonhuman; osmoregulation; phylogenetic tree; phylogeny; protozoon; salinity; scanning electron microscopy; sequence analysis | English | 2022 | 2022-08-05 | 10.3389/fmicb.2022.960621 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Antibacterial Effects of Recombinant Endolysins in Disinfecting Medical Equipment: A Pilot Study | Nosocomial infections caused by multidrug-resistant (MDR) bacteria are severe life-threatening factors. Endolysins (lysins) degrade the bacterial cell wall peptidoglycan and may help control pathogens, especially MDR bacteria prevalent in hospital settings. This study was conducted to verify the potential of lysin as disinfectant to kill bacteria contaminating medical devices that cause hospital infections. Eight catheters removed from hospitalized patients were collected and tested for their ability to kill bacteria contaminating the catheters using two lysins, LysSS and CHAP-161. Catheter-contaminating bacterial species were isolated and identified by 16s rRNA sequencing. From the eight catheters, bacteria were cultured from seven catheters, and five bacterial species (Bacillus megaterium, Bacillus muralis, Corynebacterium striatum, Enterococcus faecium, and Staphylococcus epidermidis) were identified. LysSS could inhibit catheter-contaminating bacteria, including C. striatum and S. epidermidis, compared with untreated controls but could not inhibit the growth of E. faecium. CHAP-161 showed more bactericidal effects than LysSS, but could not inhibit the growth of S. epidermidis. This study showed the potential of lysin as an alternative disinfectant for hazardous chemical disinfectants used in hospitals. | Choi, Yoon-Jung; Kim, Shukho; Bae, Sohyun; Kim, Yoonjung; Chang, Hyun-Ha; Kim, Jungmin | Kyungpook Natl Univ, Sch Med, Dept Microbiol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Allergy & Infect Dis, Daegu, South Korea | Kim, Shukho/AGG-1087-2022 | 57220082311; 24341187900; 57219699506; 57203160508; 7407521688; 57211297681 | minkim@knu.ac.kr; | FRONTIERS IN MICROBIOLOGY | FRONT MICROBIOL | 1664-302X | 12 | SCIE | MICROBIOLOGY | 2022 | 5.2 | 27.8 | 0.69 | 2025-06-25 | 7 | 7 | nosocomial infection; catheter; endolysin; drug resistance; disinfectant | ACINETOBACTER-BAUMANNII; BIOFILM; BACTERIOPHAGES; INFECTIONS; VIRULENCE | catheter; disinfectant; drug resistance; endolysin; nosocomial infection | disinfectant agent; RNA 16S; Acinetobacter baumannii; antibacterial activity; antibiotic resistance; antibiotic sensitivity; antimicrobial activity; Article; Bacillus cereus; Bacillus megaterium; Bacillus muralis; bacterial cell wall; bacterial growth; bacterial strain; bactericidal activity; bacteriophage; Candida albicans; colony forming unit; controlled study; corpus striatum; Corynebacterium striatum; device infection; disk diffusion; Enterococcus faecium; Escherichia coli; hospital infection; minimum bactericidal concentration; minimum inhibitory concentration; MTT assay; nonhuman; pilot study; protein purification; quality control; seasonal variation; Staphylococcus aureus; Staphylococcus epidermidis; Western blotting | English | 2022 | 2022-03-02 | 10.3389/fmicb.2021.773640 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Comparative analysis of scalp and gut microbiome in androgenetic alopecia: A Korean cross-sectional study | Androgenetic alopecia (AGA) is a non-scarring and progressive form of hair loss occurring in both men and women. Although genetic predisposition and sex steroid hormones are the main causes, many factors remain unknown, and various extrinsic factors can negatively affect the lifespan of hair. We investigated skin-gut axis microorganisms as potential exogenous factors causing AGA, through comparative analyses of the scalp and gut microbiome in individuals with and without AGA in a Korean cohort. Using 16S rRNA gene sequencing, we characterized the scalp and gut microbiomes of 141 individuals divided into groups by sex and presence of AGA. Alpha diversity indices in the scalp microbiome were generally higher in individuals with AGA than in healthy controls. These indices showed a strong negative correlation with scalp-inhabitant bacteria (Cutibacterium and Staphylococcus), indicating that the appearance of non-inhabitant bacteria increases as hair loss progresses. No significant differences in diversity were observed between the gut microbiomes. However, bacterial functional differences, such as bile acid synthesis and bacterial invasion of epithelial cells, which are related to intestinal homeostasis, were observed. The networks of the scalp and gut microbiome were more complex and denser with higher values of the network topology statistic coefficient values (i.e., transitivity, density, and degree centrality) and more unique associations in individuals with AGA than in healthy controls. Our findings reveal a link between skin-gut microorganisms and AGA, indicating the former's potential involvement in the latter's development. Additionally, these results provide evidence for the development of cosmetics and therapeutics using microorganisms and metabolites involved in AGA. | Jung, Da-Ryung; Yoo, Hye-Young; Kim, Min-Ji; Singh, Vineet; Park, Sung-Ha; Jeong, Minsoo; Park, Byoung-Jun; Shin, Jae-Ho | Kyungpook Natl Univ, Dept Appl Biosci, Daegu, South Korea; Kolmar Korea Co Ltd, Skin & Nat Prod Lab, Seoul, South Korea; Kyungpook Natl Univ, Dept Integrat Biotechnol, Daegu, South Korea; Kyungpook Natl Univ, NGS Core Facil, Daegu, South Korea | ; Kim, Min-Ji/Z-5205-2019; Singh, Vineet/ABC-7000-2021; shin, Jaeho/K-6792-2013 | 57221116102; 57539450400; 57127351600; 57211642447; 57827004100; 57292954900; 57199829184; 57224125922 | A2001@kolmar.co.kr;jhshin@knu.ac.kr; | FRONTIERS IN MICROBIOLOGY | FRONT MICROBIOL | 1664-302X | 13 | SCIE | MICROBIOLOGY | 2022 | 5.2 | 27.8 | 1.27 | 2025-06-25 | 13 | 15 | androgenetic alopecia; scalp microbiome; gut microbiome; amplicon sequencing; network | PATTERN HAIR LOSS; EXOGENOUS FACTORS; SKIN; MECHANISMS; BIFIDOBACTERIA; UPDATE; BIOTIN | amplicon sequencing; androgenetic alopecia; gut microbiome; network; scalp microbiome | RNA 16S; adult; alopecia; amplicon; Article; Bacteroides; Bifidobacterium; Butyricicoccus; clinical assessment; clinical evaluation; cohort analysis; comparative study; controlled study; Corynebacterium; cross-sectional study; DNA extraction; DNA sequencing; epithelium cell; female; human; human experiment; intestine flora; Korean (people); Lachnoclostridium; Lawsonella; major clinical study; male; male type alopecia; Massilia; microbial community; microbiome; nonhuman; Oscillospiraceae; Paenibacillus; Parabacteroides; Prevotella; Propionibacterium; Pseudomonas; RNA sequencing; Ruminococcaceae; scalp microbiome; Staphylococcus | English | 2022 | 2022-12-12 | 10.3389/fmicb.2022.1076242 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Differential roles of reflection and brooding on the relationship between perceived stress and life satisfaction during the COVID-19 pandemic: A serial mediation study | Perceived stress is associated with low life satisfaction; however, the underlying mechanism is relatively underexplored. This study investigated whether rumination might mediate this link during the highly stressful COVID-19 pandemic. Building on the distinction between the subtypes of rumination, we predicted that reflection and brooding would sequentially mediate this relationship and that maladaptive brooding would negatively influence life satisfaction. A representative sample of 316 adults was recruited from the greater Daegu area, where the first massive outbreak occurred in South Korea. After informed consent was obtained, they completed a package of questionnaires that included demographics, COVID-19-related experiences, perceived stress, life satisfaction, and rumination. A serial mediation analysis showed that reflection and brooding sequentially mediated the relationship between perceived stress and life satisfaction. As predicted, only brooding was negatively related to life satisfaction. In contrast, reflection per se was positively related to life satisfaction, and it negatively affected life satisfaction only through brooding. Our results extended the negative effect of brooding, as compared to reflection, in the pandemic. Given that reflection may easily turn into brooding under stress, it will be necessary to develop ways to guide people to counteract brooding while maintaining a reflective self-focus to preserve their well-being. | Kim, Bin-Na; Kang, Hyo Shin | Gachon Univ, Dept Psychol, Seongnam, South Korea; Kyungpook Natl Univ, Dept Psychol, 80 Daehak Ro, Daegu 41566, South Korea | 56125185200; 57219595147 | hyoshin.kang@knu.ac.kr; | PERSONALITY AND INDIVIDUAL DIFFERENCES | PERS INDIV DIFFER | 0191-8869 | 1873-3549 | 184 | SSCI | PSYCHOLOGY, SOCIAL | 2022 | 4.3 | 27.8 | 1.66 | 2025-06-25 | 13 | 14 | Rumination; Reflection; Brooding; Perceived stress; Life satisfaction; COVID-19 | PRIVATE SELF-CONSCIOUSNESS; RUMINATION; DEPRESSION; REACTIVITY; PREDICTORS; HEALTH; IMPACT; FOCUS; MODEL | Brooding; COVID-19; Life satisfaction; Perceived stress; Reflection; Rumination | English | 2022 | 2022-01 | 10.1016/j.paid.2021.111169 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Editorial Material | Editorial: Microorganisms for Consolidated 2nd Generation Biorefining | Kim, Soo Rin; Eckert, Carrie A.; Mazzoli, Roberto | Kyungpook Natl Univ, Res Inst Tailored Food Technol, Sch Food Sci & Biotechnol, Daegu, South Korea; Oak Ridge Natl Lab, Biosci Div, Synthet Biol Grp, Oak Ridge, TN USA; Univ Turin, Dept Life Sci & Syst Biol, Lab Prote & Metab Engn Prokaryotes, Struct & Funct Biochem, Turin, Italy | ECKERT, CARRIE/V-8199-2017; Kim, Soo Rin/X-2192-2019 | 36659584200; 28067800000; 36837832500 | roberto.mazzoli@unito.it; | FRONTIERS IN MICROBIOLOGY | FRONT MICROBIOL | 1664-302X | 13 | SCIE | MICROBIOLOGY | 2022 | 5.2 | 27.8 | 0.29 | 2025-06-25 | 0 | 1 | biomass pre-treatment; recombinant cellulolytic strategy; native cellulolytic strategy; metabolic engineering; cellulase; solvent tolerance; metabolic burden | CLOSTRIDIUM-CELLULOVORANS; METABOLIC BURDEN; FERMENTATION; BUTANOL; THERMOCELLUM; BIOBUTANOL; CHALLENGES; SECRETION; BACTERIA; FUSANTS | biomass pre-treatment; cellulase; metabolic burden; metabolic engineering; native cellulolytic strategy; recombinant cellulolytic strategy; solvent tolerance | acid; alcohol; amylase; cellulose; furan derivative; glucan 1,4 alpha glucosidase; heat shock protein; hemicellulose; lignin; lignocellulose; lipid; protein; protein serine threonine kinase; biodegradation; biomass; biomass production; Clostridium acetobutylicum; Clostridium cellulolyticum; Clostridium cellulovorans; Clostridium thermocellum; Editorial; fermentation; food industry; gene overexpression; genome analysis; herbivore; homeostasis; lipid storage; liquid; metabolic engineering; microbial community; microbial growth; microorganism; Myceliophthora thermophila; nonhuman; pH; physiological stress; protein degradation; protein expression; RNA translation; saccharification; Saccharomyces cerevisiae; Yarrowia lipolytica | English | 2022 | 2022-06-17 | 10.3389/fmicb.2022.940610 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Engineering of lysin by fusion of antimicrobial peptide (cecropin A) enhances its antibacterial properties against multidrug-resistant Acinetobacter baumannii | Most clinical isolates of Acinetobacter baumannii, a nosocomial pathogen, are multidrug-resistant (MDR), fueling the search for alternative therapies. Bacteriophage-derived endolysins have potent antibacterial activities and are considered as alternatives to antibiotics against A. baumannii infection. Gram-negative bacteria possess outer lipid membrane that prevents direct contact between the endolysins and the cell wall. We hypothesized that the fusion of antimicrobial peptide (AMP) with endolysin could help to reduce bacterial endolysin resistance and increase antimicrobial activity by membrane permeability action. Accordingly, we fused cecropin A, a commonly used AMP, with the N-terminus of AbEndolysin, which enhances the bactericidal activity of the chimeric endolysin. The bactericidal activity of cecropin A-fused AbEndolysin increased by at least 2-8 fold for various MDR A. baumannii clinical isolates. The in vitro bactericidal activity results also showed higher bacterial lysis by the chimeric endolysin than that by the parental lysin. The engineered AbEndolysin (eAbEndolysin) showed synergistic effects with the beta-lactam antibiotics cefotaxime, ceftazidime, and aztreonam, and an additive effect with meropenem and imipenem. eAbEndolysin had no cytotoxic effect on A549 cell line and rescued mice (40% survival rate) from systemic A. baumannii infection. Together, these findings suggest the potential of lysin therapy and may prompt its use as an alternative to antibiotics. | Islam, Md Maidul; Kim, Dooyoung; Kim, Kyeongmin; Park, Su-Jin; Akter, Samia; Kim, Jeongah; Bang, Seunghyeok; Kim, Shukho; Kim, Jungmin; Lee, Je Chul; Hong, Chang-Won; Shin, Minsang | Kyungpook Natl Univ, Sch Med, Dept Microbiol, Daegu, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Funct Biomat Res Ctr, Jeongeup, South Korea; Kyungpook Natl Univ, Sch Med, Dept Physiol, Daegu, South Korea | Kim, Shukho/AGG-1087-2022; Islam, Md. Maidul/AAX-1696-2021 | 57216605059; 57270622500; 57216604095; 7501829452; 57920188500; 57920359700; 57920536600; 24341187900; 57211297681; 25930392000; 55567018400; 7401536650 | shinms@knu.ac.kr; | FRONTIERS IN MICROBIOLOGY | FRONT MICROBIOL | 1664-302X | 13 | SCIE | MICROBIOLOGY | 2022 | 5.2 | 27.8 | 2.06 | 2025-06-25 | 24 | 21 | Acinetobacter baumannii; cecropin A; endolysin; antibacterial activity; synergistic effect | PHAGE LYSIN; ENDOLYSINS; PROTEINS | Acinetobacter baumannii; antibacterial activity; cecropin A; endolysin; synergistic effect | ampicillin; antibiotic agent; antiinfective agent; aztreonam; beta lactam antibiotic; carbapenem; cecropin A; cefepime; cefotaxime; ceftazidime; ceftriaxone; clavulanic acid; colistin; endolysin; extended spectrum beta lactamase; imipenem; lysine; meropenem; neutralizing antibody; polypeptide antibiotic agent; tazobactam; ticarcillin; trimethoprim; unclassified drug; A-549 cell line; Acinetobacter baumannii; amino terminal sequence; animal cell; animal experiment; animal model; animal tissue; antibacterial activity; antibiotic resistance; antibiotic sensitivity; antimicrobial activity; Article; bacterial growth; bacterial strain; bactericidal activity; bacteriophage; bacterium isolate; bacterium isolation; broth dilution; colony forming unit; controlled study; cytotoxicity assay; enzyme activity; Escherichia coli; female; field emission scanning electron microscopy; fractional inhibitory concentration index; gene overexpression; membrane permeability; minimum bactericidal concentration; minimum inhibitory concentration; mouse; multidrug resistant Acinetobacter baumannii; nonhuman; optical density; pH measurement; plasmid; polymerase chain reaction; protein expression; protein purification; protein synthesis; Pseudomonas aeruginosa; quality control; salinity; Sanger sequencing; survival rate; synergistic effect; temperature | English | 2022 | 2022-09-26 | 10.3389/fmicb.2022.988522 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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