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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | Meeting Abstract | Importance of pharyngeal residue as a marker of treatment in Korean spinal and bulbar muscular atrophy patients | Park, J.; Kang, M.; Cho, H. | Kyungpook Natl Univ, Daegu, South Korea; Dong A Univ, Busan, South Korea | NEUROMUSCULAR DISORDERS | NEUROMUSCULAR DISORD | 0960-8966 | 1873-2364 | 30 | SCIE | CLINICAL NEUROLOGY;NEUROSCIENCES | 2020 | 4.296 | 30.1 | 0 | English | 2020 | 2020-10 | 10.1016/j.nmd.2020.08.088 | 바로가기 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Review | Proteomic examination of the neuroglial secretome: lessons for the clinic | Introduction: Glial cells are closely associated with neurons located throughout the nervous system and regulate neuronal activity and function through various mechanisms including the secretion of proteins and other signaling molecules. Glia-secreted proteins play crucial roles in modulating neuronal function in physiological and pathological conditions. Aberrant activation of glial cells leading to neuroinflammation is a common phenomenon observed in various neurological disorders. Aberrantly activated glial cells secrete proteins in disease-specific manner and can be exploited as a repository for novel biomarker discovery. Areas covered: In this review, we describe the recent advances in proteomic techniques, highlighting the need for their application to the secretomic field. Studies regarding the secretome profile of glial cells published within the last 5 years are discussed in detail. The use of glia-based biomarkers in various neuroinflammatory and neurodegenerative diseases is also discussed. Expert opinion: Precise diagnosis and timely treatment of neurological disorders remains a challenge and glia-focused research to identify specific biomarkers appears to be a promising approach to combat these disorders. Recent technological advancement in proteomic research would open new frontiers for more rigorous analysis of glial secretome variations over time and the discovery/development of novel biomarkers for neurological disorders. | Kim, Jong-Heon; Afridi, Ruqayya; Lee, Won-Ha; Suk, Kyoungho | Kyungpook Natl Univ, Sch Med, Brain Sci & Engn Inst, Daegu, South Korea; Kyungpook Natl Univ, BK21 Plus KNU Biomed Convergence Program, Brain Sci & Engn Inst, Dept Pharmacol,Sch Med, Daegu, South Korea; Kyungpook Natl Univ, BK21 Plus KNU Creat BioRes Grp, Sch Life Sci, Daegu, South Korea | 57203324811; 57200759784; 57205609794; 7005114595 | ksuk@knu.ac.kr; | EXPERT REVIEW OF PROTEOMICS | EXPERT REV PROTEOMIC | 1478-9450 | 1744-8387 | 17 | 3 | SCIE | BIOCHEMICAL RESEARCH METHODS | 2020 | 3.94 | 30.1 | 0.11 | 2025-06-25 | 5 | 6 | Glia; secretome; neuroinflammation | CENTRAL-NERVOUS-SYSTEM; PROGRESSIVE MULTIPLE-SCLEROSIS; TRAUMATIC BRAIN-INJURY; SCHWANN-CELLS REVEALS; ALZHEIMERS-DISEASE; EPENDYMAL CELLS; NEUROTROPHIC FACTOR; NEURONAL INJURY; MICROGLIA; ASTROCYTES | Glia; neuroinflammation; secretome | Biomarkers; Humans; Neurodegenerative Diseases; Neuroglia; Neurons; Proteomics; biological marker; protein; proteome; cell culture; degenerative disease; exosome; glia cell; human; multiple sclerosis; nervous system inflammation; neurologic disease; nonhuman; proteomics; Review; secretomics; single cell analysis; genetics; glia; metabolism; nerve cell; pathology | English | 2020 | 2020-03-03 | 10.1080/14789450.2020.1745069 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Reversible Fluorescence Switching of Metal-Organic Framework Nanoparticles for Use as Security Ink and Detection of Pb²⁺ Ions in Aqueous Media | To date, numerous materials, including various quantum dots and dyes, have been widely used for the ultrasensitive detection of toxic metal ions and as security inks to hide information. Nevertheless, because of the poor dispersibility of solid-state materials, security inks based on such materials have been scarcely reported. Herein, a highly dispersible and water-stable metal-organic framework (MOF; NH2-MIL-125(Ti)) is used as an invisible security ink for data coding, encryption, and decryption via its "turn-on/off" switching by treatment with ethylenediaminetetraacetic acid and Pb2+. Notably, the concentration of the Pb2+ solution used to turn off the fluorescence of the MOF was lower than the limit established by several regulatory agencies for drinking water. The MOF was also used as a sensitive probe for the rapid and ultrasensitive detection of Pb2+ ions at a concentration of 7.7 pM which is one of the lowest detection limits reported for such a system. The MOF also shows high selectivity for various transition metal ions that can competitively bound on the ligand. Analyses using Fourier transform infrared spectroscopy,X-ray photoelectron, and UV photoemission spectroscopy clearly revealed the roles of the surface functional groups and the mechanism of the "on/off" switching behavior of the MOF. | Venkateswarlu, Sada; Reddy, Ankireddy Seshadri; Panda, Atanu; Sarkar, Debraj; Son, Younghu; Yoon, Minyoung | Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea; Gachon Univ, Dept Nanochem, Seongnam 13120, South Korea; Gachon Univ, Dept Chem & Biol Engn, Seongnam 13120, South Korea | ; Panda, Dr. Atanu/AAU-7780-2020; Son, Younghu/AAX-9531-2021; Panda, Atanu/AAU-7780-2020; venkateswarlu, sada/P-2034-2018 | 55649254900; 57197811761; 57201632042; 57213982158; 57216839175; 25222186500 | myyoon@knu.ac.kr; | ACS APPLIED NANO MATERIALS | ACS APPL NANO MATER | 2574-0970 | 3 | 4 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2020 | 5.097 | 30.1 | 2.47 | 2025-06-25 | 53 | 59 | Metal-organic framework; NH2-MIL-125(Ti); security ink; encryption; decryption; lead detection; sensor | CONVERSION; GOLD; PHOTOCATALYST; FABRICATION; REMOVAL; PB(II) | decryption; encryption; lead detection; Metal-organic framework; NH<sub>2</sub>-MIL-125(Ti); security ink; sensor | Cryptography; Ethylenediaminetetraacetic acid; Fluorescence; Fourier transform infrared spectroscopy; Metal ions; Metal nanoparticles; Metal-Organic Frameworks; Organometallics; Photoelectron spectroscopy; Potable water; Semiconductor quantum dots; Toxic materials; Transition metal compounds; Transition metals; Dispersibilities; Fluorescence switching; Regulatory agencies; Solid-state materials; Surface functional groups; Switching behaviors; Toxic metal ions; Ultrasensitive detection; Lead removal (water treatment) | English | 2020 | 2020-04-24 | 10.1021/acsanm.0c00392 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Meeting Abstract | Symptomatic female carrier of Duchenne muscular dystrophy with a novel single-base deletion mutation mimicking exon deletion in MLPA | Lee, G.; Lee, Y.; Lee, J. | Kyungpook Natl Univ Hosp, Daegu, South Korea | NEUROMUSCULAR DISORDERS | NEUROMUSCULAR DISORD | 0960-8966 | 1873-2364 | 30 | SCIE | CLINICAL NEUROLOGY;NEUROSCIENCES | 2020 | 4.296 | 30.1 | 0 | English | 2020 | 2020-10 | 10.1016/j.nmd.2020.08.135 | 바로가기 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | Article | Dark Matter benchmark models for early LHC Run-2 Searches: Report of the ATLAS/CMS Dark Matter Forum | This document is the final report of the ATLAS-CMS Dark Matter Forum, a forum organized by the ATLAS and CMS collaborations with the participation of experts on theories of Dark Matter, to select a minimal basis set of dark matter simplified models that should support the design of the early LHC Run-2 searches. A prioritized, compact set of benchmark models is proposed, accompanied by studies of the parameter space of these models and a repository of generator implementations. This report also addresses how to apply the Effective Field Theory formalism for collider searches and present the results of such interpretations. (C) 2019 The Authors. Published by Elsevier B.V. | Abercrombie, Daniel; Akchurin, Nural; Akilli, Ece; Alcaraz Maestre, Juan; Allen, Brandon; Gonzalez, Barbara Alvarez; Andrea, Jeremy; Arbey, Alexandre; Azuelos, Georges; Azzi, Patrizia; Backovic, Mihailo; Bai, Yang; Banerjee, Swagato; Beacham, James; Belyaev, Alexander; Boveia, Antonio; Brennan, Amelia Jean; Buchmueller, Oliver; Buckley, Matthew R.; Busoni, Giorgio; Buttignol, Michael; Cacciapaglia, Giacomo; Caputo, Regina; Carpenter, Linda; Castro, Nuno Filipe; Ceballos, Guillelmo Gomez; Cheng, Yangyang; Chou, John Paul; Cortes Gonzalez, Arely; Cowden, Chris; D'Eramo, Francesco; De Cosa, Annapaola; De Gruttola, Michele; De Roeck, Albert; De Simone, Andrea; Deandrea, Aldo; Demiragli, Zeynep; DiFranzo, Anthony; Doglioni, Caterina; du Pree, Tristan; Erbacher, Robin; Erdmann, Johannes; Fischer, Cora; Flaecher, Henning; Fox, Patrick J.; Fuks, Benjamin; Genest, Marie-Helene; Gomber, Bhawna; Goudelis, Andreas; Gramling, Johanna; Gunion, John; Hahn, Kristian; Haisch, Ulrich; Harnik, Roni; Harris, Philip C.; Hoepfner, Kerstin; Hoh, Siew Yan; Hsu, Dylan George; Hsu, Shih-Chieh; Iiyama, Yutaro; Ippolito, Valerio; Jacques, Thomas; Ju, Xiangyang; Kahlhoefer, Felix; Kalogeropoulos, Alexis; Kaplan, Laser Seymour; Kashif, Lashkar; Khoze, Valentin V.; Khurana, Raman; Kotov, Khristian; Kovalskyi, Dmytro; Kulkarni, Suchita; Kunori, Shuichi; Kutzner, Viktor; Lee, Hyun Min; Lee, Sung-Won; Liew, Seng Pei; Lin, Tongyan; Lowette, Steven; Madar, Romain; Malik, Sarah; Maltoni, Fabio; Martinez Perez, Mario; Mattelaer, Olivier; Mawatari, Kentarou; McCabe, Christopher; Megy, Theo; Morgante, Enrico; Mrenna, Stephen; Moon, Chang-Seong; Narayanan, Siddharth M.; Nelson, Andy; Novaes, Sergio F.; Padeken, Klaas Ole; Pani, Priscilla; Papucci, Michele; Paulini, Manfred; Paus, Christoph; Pazzini, Jacopo; Penning, Bjorn; Peskin, Michael E.; Pinna, Deborah; Pazzini, Jacopo; Penning, Bjorn; Peskin, Michael E.; Pinna, Deborah; Procura, Massimiliano; Qazi, Shamona F.; Racco, Davide; Re, Emanuele; Riotto, Antonio; Rizzo, Thomas G.; Roehrig, Rainer; Salek, David; Pineda, Arturo Sanchez; Sarkar, Subir; Schmidt, Alexander; Schramm, Steven Randolph; Shepherd, William; Singh, Gurpreet; Soffi, Livia; Srimanobhas, Norraphat; Sung, Kevin; Tait, Tim M. P.; Theveneaux-Pelzer, Timothee; Thomas, Marc; Tosi, Mia; Trocino, Daniele; Undleeb, Sonaina; Vichi, Alessandro; Wang, Fuquan; Wang, Lian-Tao; Wang, Ren-Jie; Whallon, Nikola; Worm, Steven; Wu, Mengqing; Wu, Sau Lan; Yang, Hongtao; Yang, Yong; Yu, Shin-Shan; Zaldivar, Bryan; Zanetti, Marco; Zhang, Zhiqing; Zucchetta, Alberto | Oviedo Univ, Oviedo, Spain; Louisville Univ, Louisville, KY 40292 USA; Duke Univ, Durham, NC 27706 USA; CERN, Geneva, Switzerland; Heidelberg Univ, Max Planck Inst, Heidelberg, Germany; Cornell Univ, Ithaca, NY 14853 USA; INFN Padua, Padua, Italy; Boston Univ, Boston, MA 02215 USA; Rutgers State Univ, Piscataway, NJ USA; NIKHEF, Amsterdam, Netherlands; Paris LPTHE, Paris, France; Hyderabad Univ, Hyderabad, Andhra Pradesh, India; UC Irvine, Irvine, CA USA; Munich MPI, Munich, Germany; MIT, Cambridge, MA 02139 USA; INFN Rome, Rome, Italy; SISSA Trieste, Trieste, Italy; LBL, Berkeley, CA USA; Rhein Westfal TH Aachen, Aachen, Germany; Princeton Univ, Princeton, NJ 08544 USA; Delhi Univ, Delhi, India; Florida Univ, Gainesville, FL USA; Univ Maryland, College Pk, MD 20742 USA; Texas Tech Univ, Lubbock, TX 79409 USA; Univ Geneva, DPNC, Geneva, Switzerland; CIEMAT, Madrid, Spain; Univ Lyon, Lyon, France; CNRS, Ctr Rech Astrophys Lyon, Lyon, France; Ecole Normale Super Lyon, Lyon, France; CERN, Div Theory, Geneva, Switzerland; Univ Montreal, Montreal, PQ, Canada; TRIUMF, Vancouver, BC, Canada; INFN Padova, Padua, Italy; Univ Wisconsin, Madison, WI USA; Ohio State Univ, Columbus, OH 43210 USA; Rutherford Appleton Lab, Southampton, Hants, England; Univ Southampton, Southampton, Hants, England; Univ Melbourne, Melbourne, Vic, Australia; Imperial Coll London, London, England; Rutgers State Univ, Dept Phys & Astron, Piscataway, NJ USA; SISSA, Trieste, Italy; INFN, Sez Trieste, Trieste, Italy; Univ Strasbourg, Inst Pluridisciplinaire Hubert Curien, Dept Rech Subatom, CNRS IN2P3, Strasbourg, France; Univ Calif Santa Cruz, Santa Cruz Inst Particle Phys, Dept Phys, Santa Cruz, CA 95064 USA; Univ Calif Santa Cruz, Dept Astron & Astrophys, Santa Cruz, CA 95064 USA; LIP Minho, Braga, Portugal; Univ Porto, Fac Ciencias, Dept Fis & Astron, Porto, Portugal; Univ Chicago, Chicago, IL 60637 USA; Rutgers State Univ, Piscataway, NJ USA; IFAE Barcelona, Barcelona, Spain; Univ Calif Berkeley, Berkeley, CA 94720 USA; LBNL, Berkeley, CA USA; Univ Zurich, Zurich, Switzerland; Univ Lyon, Lyon, France; Univ Lyon 1, CNRS, IN2P3, UMR5822, Lyon, France; Univ Calif Irvine, Dept Phys & Astron, Irvine, CA USA; Dept Theoret Phys, Irvine, CA USA; Lund Univ, Lund, Sweden; San Diego Univ, San Diego, CA USA; Louvain CP3, Louvain, Belgium; Osaka Univ, Osaka, Japan; Kings Coll London, London, England; Freiburg Univ, Freiburg, Germany; DESY, Hamburg, Germany; Kyungpook Natl Univ, Daegu, South Korea; Vanderbilt Univ, 221 Kirkland Hall, Nashville, TN 37235 USA; Brandeis Univ, Waltham, MA 02254 USA; Perimeter, Atlanta, GA USA; Annecy LAPTH, Annecy, France; Rhein Westfal TH Aachen, Aachen, Germany; Mainz Univ, Mainz, Germany; Univ Ghent, Ghent, Belgium; LPHE Lausanne, Lausanne, Switzerland; Univ Birmingham, Birmingham, W Midlands, England; Beijing IHEP, Beijing, Peoples R China; Shanghai Jiao Tong Univ, Shanghai, Peoples R China; LAPTh, Annecy, France; Zurich Univ, Zurich, Switzerland; Univ Calif Davis, Davis, CA USA; Tech Univ Dortmund, Inst Expt Phys 4, Dortmund, Germany; Univ Bristol, HH Wills Phys Lab, Bristol, Avon, England; Fermilab Natl Accelerator Lab, Batavia, IL USA; Univ Strasbourg, Inst Pluridisciplinaire Hubert Curien, Dept Rech Subatom, CNRS IN2P3, Strasbourg, France; Univ Grenoble Alpes, LPSC, CNRS, IN2P3, Grenoble, France; Austrian Acad Sci, Inst Hochenergiephys, Vienna, Austria; Univ Geneva, DPNC, Geneva, Switzerland; Northwestern Univ, Evanston, IL 60208 USA; Univ Oxford, Rudolf Peierls Ctr Theoret Phys, Oxford, England; Fermilab Natl Accelerator Lab, Dept Theoret Phys, Batavia, IL USA; Univ Malaya, Natl Ctr Particle Phys, Kuala Lumpur, Malaysia; Harvard Univ, Lab Particle Phys & Cosmol, Cambridge, MA 02138 USA; Univ Geneva, Dept Theoret Phys, Geneva, Switzerland; Univ Durham, Inst Particle Phys Phenomenol, Durham, England; Natl Cent Univ, Taoyuan, Taiwan; Rhein Westfal TH Aachen, Phys Inst A 3, Aachen, Germany; Chung Ang Univ, Dept Phys, Seoul, South Korea; Univ Tokyo, Dept Phys, Tokyo, Japan; Univ Chicago, Kavli Inst Cosmol Phys, Chicago, IL 60637 USA; Vrije Univ Brussel IIHE, Brussels, Belgium; Lab Phys Corpusculaire, Clermont Ferrand, France; Catholic Univ Louvain, Ctr Cosmol Particle Phys & Phenomenol CP3, Louvain, Belgium; IPPP Durham, Durham, England; Vrije Univ Brussel, Theoret Nat Kunde, Brussels, Belgium; Vrije Univ Brussel, IIHE ELEM, Brussels, Belgium; Int Solvay Inst, Brussels, Belgium; Univ Amsterdam, GRAPPA, Amsterdam, Netherlands; FNAL, Batavia, IL USA; Univ Estadual Paulista, Sao Paulo, Brazil; Univ Calif Irvine, Irvine, CA USA; Stockholm Univ, Stockholm, Sweden; Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Theoret Phys Grp, Berkeley, CA 94720 USA; Univ Calif Berkeley, Berkeley Ctr Theoret Phys, Berkeley, CA 94720 USA; Carnegie Mellon Univ, Pittsburgh, PA 15213 USA; Stanford Univ, SLAC, Stanford, CA 94305 USA; Univ Wien, Vienna, Austria; Quaid I Azam Univ, Natl Ctr Phys, Islamabad, Pakistan; Univ Oxford, Rudolf Peierls Ctr Theoret Phys, Oxford, England; SLAC, Menlo Pk, CA USA; Max Planck Inst Phys & Astrophys, Munich, Germany; Nikhef, Amsterdam, Netherlands; GRAPPA, Haarlem, Netherlands; INFN, Sez Napoli, Naples, Italy; Univ Napoli, Dipartimento Fis, Naples, Italy; Univ Oxford, Rudolf Peierls Ctr Theoret Phys, Oxford, England; Niels Bohr Inst, Copenhagen, Denmark; Univ Hamburg, Hamburg, Germany; Univ Calif Santa Cruz, Dept Phys, Santa Cruz, CA 95064 USA; Santa Cruz Inst Particle Phys, Santa Cruz, CA USA; Univ Copenhagen, Niels Bohr Int Acad, Copenhagen, Denmark; Chulalongkorn Univ, Bangkok, Thailand; Cornell Univ, Ithaca, NY 14853 USA; Chulalongkorn Univ, Fac Sci, Dept Phys, Bangkok, Thailand; Northwestern Univ, Evanston, IL 60208 USA; Univ Calif Irvine, Dept Phys & Astron, Irvine, CA USA; Clermont Univ, Phys Corpusculaire Lab, Clermont Ferrand, France; Univ Blaise Pascal, Clermont Ferrand, France; CNRS, IN2P3, Clermont Ferrand, France; Southampton Univ, Southampton, Hants, England; Univ Padua, Padua, Italy; INFN, Padua, Italy; Northeastern Univ, Boston, MA 02115 USA; Univ Chicago, Enrico Fermi Inst, Chicago, IL 60637 USA; Univ Chicago, Dept Phys, Chicago, IL 60637 USA; Univ Chicago, Kavli Inst Cosmol Phys, Chicago, IL 60637 USA; Northeastern Univ, Dept Phys, Boston, MA 02115 USA; Univ Washington, Phys, Seattle, WA 98195 USA; Rutherford Appleton Lab, Particle Phys Dept, Chilton, England; Univ Grenoble Alpes, Lab Phys Subatom & Cosmol, CNRS, IN2P3, Grenoble, France; Univ Zurich, Zurich, Switzerland; Natl Cent Univ, Taoyuan, Taiwan; Univ Libre Bruxelles, Brussels, Belgium; Univ Paris Sud 11, Lab Accelerateur Lineaire, Paris, France; CNRS, IN2P3, Paris, France; Univ Padua, Padua, Italy | D'Eramo, Francesco/AGD-5179-2022; Vichi, Alessandro/ACE-8362-2022; Belyaev, Alexander/F-6637-2015; Re, Emanuele/P-2344-2019; Novaes, Sergio/D-3532-2012; Ciangottini, Diego/HJH-5914-2023; Lin, Tongyan/GOL-1216-2022; Hoh, Siew Yan/AAM-9562-2021; Gonzalez, Adriana/KFB-1711-2024; Zaldivar, Bryan/AAI-1332-2019; Worm, Steven/I-3575-2012; Fuks, Benjamin/KHZ-5471-2024; Parida, Bibhuti/T-3730-2018; Mrenna, Stephen/KIL-6081-2024; Paulini, Manfred/N-7794-2014; Gómez-Vargas, Juan Carlos/S-5253-2016; gunion, john/AAJ-9946-2021; Soffi, Livia/HSC-0774-2023; Moon, Chang-Seong/J-3619-2014; Morgante, Enrico/AAG-8145-2019; MAESTRE, JUAN/I-5763-2015; Banerjee, Swagato/AAN-3326-2021; tosi, mia/J-5777-2012; Castro, Nuno/AAB-3648-2019; Carpenter, Linda/M-9765-2015; ALCARAZ MAESTRE, JUAN/I-5763-2015; Peitzmann, Thomas/K-2206-2012; Hoh, Siewyan/AAM-9562-2021; Yang, Yong/D-9724-2017; Azzi, Patrizia/H-5404-2012; Iiyama, Yutaro/LXA-4378-2024; Sarkar, Subir/G-5978-2011; Ippolito, Valerio/L-1435-2016; Song, Weimin/AAJ-5415-2020; Trocino, Daniele/AGI-2155-2022; Howard, Michael/F-1587-2019; Di Simone, Andrea/K-6609-2013; Lowette, Steven/HKV-3341-2023; de gruttola, michele/AAN-7271-2020; Lee, Hyun/B-5268-2013; YU, SHIN-SHAN/JPW-8635-2023; Bai, Yang/JVN-9175-2024; Khurana, Raman/IUN-3205-2023; Wang, Zijian/IQU-2128-2023; Racco, Davide/HZJ-8429-2023; Demiragli, Zeynep/IZE-1919-2023; Caputo, Riccardo/I-5558-2014; Busoni, Giorgio/AAE-2286-2020; McCabe, Christopher/G-5705-2014; Gonzalez, Barbara/ABG-7021-2020 | boveia.1@osu.edu; | PHYSICS OF THE DARK UNIVERSE | PHYS DARK UNIVERSE | 2212-6864 | 27 | SCIE | ASTRONOMY & ASTROPHYSICS | 2020 | 4.243 | 30.2 | 164 | Dark Matter; Simplified models; EFT; LHC | EFFECTIVE-FIELD THEORY; TRANSVERSE-MOMENTUM; FINAL-STATES; COLLISIONS; PHYSICS | English | 2020 | 2020-01 | 10.1016/j.dark.2019.100371 | 바로가기 | 바로가기 | 바로가기 | |||||||||||
| ○ | ○ | Article | Adsorptive removal of bulky dye molecules from water with mesoporous polyaniline-derived carbon | Polyaniline-derived carbon (PDC) was obtained via pyrolysis of polyaniline under different temperatures and applied for the purification of water contaminated with dye molecules of different sizes and charge by adsorption. With increasing pyrolysis temperature, it was found that the hydrophobicity, pore size and mesopore volume increased. A mesoporous PDC sample obtained via pyrolysis at 900 degrees C showed remarkable performance in the adsorption of dye molecules, irrespective of dye charge, especially in the removal of bulky dye molecules, such as acid red 1 (AR1) and Janus green B (JGB). For example, the most competitive PDC material showed a Q(0) value (maximum adsorption capacity) 8.1 times that of commercial, activated carbon for AR1. The remarkable adsorption of AR1 and JGB over KOH-900 could be explained by the combined mechanisms of hydrophobic, pi-pi, electrostatic and van der Waals interactions. | An, Hyung Jun; Park, Jong Min; Khan, Nazmul Abedin; Jhung, Sung Hwa | Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea | ; Jhung, Sung/AAO-6683-2021 | 57200991496; 57193995796; 35170042700; 6701659467 | sung@knu.ac.kr; | BEILSTEIN JOURNAL OF NANOTECHNOLOGY | BEILSTEIN J NANOTECH | 2190-4286 | 11 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2020 | 3.649 | 30.3 | 0.79 | 2025-06-25 | 15 | 15 | acid red 1; adsorption; bulky dye molecules; Janus green B; polyaniline-derived carbon; water purification | METAL-ORGANIC FRAMEWORKS; PERSONAL CARE PRODUCTS; DOPED POROUS CARBONS; AQUEOUS-SOLUTION; EFFICIENT ADSORBENT; HAZARDOUS ORGANICS; ACTIVATED CARBONS; MALACHITE GREEN; METHYLENE-BLUE; CLOFIBRIC ACID | Acid red 1; Adsorption; Bulky dye molecules; Janus green B; Polyaniline-derived carbon; Water purification | Activated carbon; Adsorption; Azo dyes; Hydrophobicity; Pore size; Potassium hydroxide; Pyrolysis; Van der Waals forces; Adsorption capacities; Adsorptive removal; Combined mechanisms; Different sizes; Mesopore volume; Purification of water; Pyrolysis temperature; Van Der Waals interactions; Molecules | English | 2020 | 2020-04-08 | 10.3762/bjnano.11.47 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Allithiamine Exerts Therapeutic Effects on Sepsis by Modulating Metabolic Flux during Dendritic Cell Activation | Recent studies have highlighted that early enhancement of the glycolytic pathway is a mode of maintaining the pro inflammatory status of immune cells. Thiamine, a wellknown co-activator of pyruvate dehydrogenase complex, a gatekeeping enzyme, shifts energy utilization of glucose from glycolysis to oxidative phosphorylation. Thus, we hypothesized that thiamine may modulate inflammation by alleviating metabolic shifts during immune cell activation. First, using allithiamine, which showed the most potent anti-inflammatory capacity among thiamine derivatives, we confirmed the inhibitory effects of allithiamine on the lipopolysaccharide (LPS)-induced pro-inflammatory cytokine production and maturation process in dendritic cells. We applied the LPS-induced sepsis model to examine whether allithiamine has a protective role in hyper-inflammatory status. We observed that allithiamine attenuated tissue damage and organ dysfunction during endotoxemia, even when the treatment was given after the early cytokine release. We assessed the changes in glucose metabolites during LPS-induced dendritic cell activation and found that allithiamine significantly inhibited glucose-driven citrate accumulation. We then examined the clinical implication of regulating metabolites during sepsis by performing a tail bleeding assay upon allithiamine treatment, which expands its capacity to hamper the coagulation process. Finally, we confirmed that the role of allithiamine in metabolic regulation is critical in exerting anti-inflammatory action by demonstrating its inhibitory effect upon mitochondrial citrate transporter activity. In conclusion, thiamine could be used as an alternative approach for controlling the immune response in patients with sepsis. | Choi, Eun Jung; Jeon, Chang Hyun; Park, Dong Ho; Kwon, Tae-Hwan | Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu 41566, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Ophthalmol, Daegu 41944, South Korea | ; Kwon, Tae-Hwan/ABA-1981-2020 | 57218919440; 57219950349; 36676632900; 7202206089 | thkwon@knu.ac.kr; | MOLECULES AND CELLS | MOL CELLS | 1016-8478 | 0219-1032 | 43 | 11 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CELL BIOLOGY | 2020 | 5.034 | 30.3 | 0.56 | 2025-06-25 | 12 | 11 | allithiamine; citrate accumulation; lipid droplet formation; lipopolysaccharides; metabolic flux | DYSFUNCTION; SHOCK | Allithiamine; Citrate accumulation; Lipid droplet formation; Lipopolysaccharides; Metabolic flux | Animals; Dendritic Cells; Humans; Male; Mice; Sepsis; Thiamine; allithiamine; anticoagulant agent; citric acid; glucose; lipopolysaccharide; prostaglandin E2; thiamine derivative; unclassified drug; allithiamine; thiamine; animal cell; animal experiment; animal model; antiinflammatory activity; Article; cell activation; controlled study; cytokine production; cytokine release; dendritic cell; glycolysis; immune response; immunocompetent cell; in vitro study; in vivo study; inflammation; lipogenesis; lipopolysaccharide-induced endotoxemia; lipopolysaccharide-induced sepsis; male; metabolic regulation; mitochondrion; mouse; neutrophil; nonhuman; seahorse; therapy effect; tissue injury; animal; dendritic cell; human; metabolism; sepsis | English | 2020 | 2020-11 | 10.14348/molcells.2020.0198 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Cellular Contributors to Hypothalamic Inflammation in Obesity | The hypothalamus is a crucial organ for the maintenance of appropriate body fat storage. Neurons in the hypothalamic arcuate nucleus (ARH) detect energy shortage or surplus via the circulating concentrations of metabolic hormones and nutrients, and then coordinate energy intake and expenditure to maintain energy homeostasis. Malfunction or loss of hypothalamic ARH neurons results in obesity. Accumulated evidence suggests that hypothalamic inflammation is a key pathological mechanism that links chronic overconsumption of a high-fat diet (HFD) with the development of obesity and related metabolic complications. Interestingly, overnutrition-induced hypothalamic inflammation occurs specifically in the ARH, where microglia initiate an inflammatory response by releasing proinflammatory cytokines and chemokines in response to excessive fatty acid flux. Upon more prolonged HFD consumption, astrocytes and perivascular macrophages become involved and sustain hypothalamic inflammation. ARH neurons are victims of hypothalamic inflammation, but they may actively participate in hypothalamic inflammation by sending quiescence or stress signals to surrounding glia. In this mini-review, we describe the current state of knowledge regarding the contributions of neurons and glia, and their interactions, to HFD-induced hypothalamic inflammation. | Lee, Chan Hee; Suk, Kyoungho; Yu, Rina; Kim, Min-Seon | Univ Ulsan, Asan Med Ctr, Asan Inst Life Sci, Coll Med, Seoul 05505, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Coll Med, Daegu 41944, South Korea; Univ Ulsan, Dept Food Sci & Nutr, Ulsan 44610, South Korea; Univ Ulsan, Asan Med Ctr, Div Endocrinol & Metab, Coll Med, Seoul 05505, South Korea | 57207257659; 7005114595; 7401436447; 36066824400 | rinayu@ulsan.ac.kr;mskim@amc.seoul.kr; | MOLECULES AND CELLS | MOL CELLS | 1016-8478 | 0219-1032 | 43 | 5 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CELL BIOLOGY | 2020 | 5.034 | 30.3 | 0.65 | 2025-06-25 | 47 | 46 | glia; hypothalamus; inflammation; neurons; obesity | NEURON-ASTROCYTE INTERACTIONS; BETA/NF-KAPPA-B; DIET; MICROGLIA; CONSUMPTION; PLASTICITY; RESISTANCE; SIGNALS; INJURY; CNS | glia; hypothalamus; inflammation; neurons; obesity | Adipose Tissue; Animals; Cytokines; Diet, High-Fat; Energy Metabolism; Humans; Hypothalamus; Immunity, Cellular; Inflammation; Macrophages; Microglia; Neurogenic Inflammation; Neurons; Obesity; chemokine; cytokine; fatty acid; arcuate nucleus; astrocyte; body fat; caloric intake; controlled study; diagnosis; glia; homeostasis; hypothalamus; inflammation; lipid diet; lipid storage; macrophage; microglia; nerve cell; nonhuman; obesity; overnutrition; review; adipose tissue; animal; cellular immunity; energy metabolism; human; hypothalamus; immunology; inflammation; metabolism; nerve cell; neurogenic inflammation; obesity | English | 2020 | 2020-05 | 10.14348/molcells.2020.0055 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Fat Mass and Obesity-Associated (FTO) Stimulates Osteogenic Differentiation of C3H10T1/2 Cells by Inducing Mild Endoplasmic Reticulum Stress via a Positive Feedback Loop with p-AMPK | Fat mass and obesity-associated (FTO) gene helps to regulate energy homeostasis in mammals by controlling energy expenditure. In addition, FTO functions in the regulation of obesity and adipogenic differentiation; however, a role in osteogenic differentiation is unknown. This study investigated the effects of FTO on osteogenic differentiation of C3H10T1/2 cells and the underlying mechanism. Expression of osteogenic and endoplasmic reticulum (ER) stress markers were characterized by reverse-transcriptase polymerase chain reaction and western blotting. Alkaline phosphatase (ALP) staining was performed to assess ALP activity. BMP2 treatment increased mRNA expression of osteogenic genes and FTO. Overexpression of FTO increased expression of the osteogenic genes distal-less homeobox5 (Dlx5) and runt-related transcription factor 2 (Runx2). Activation of adenosine monophosphate-activated protein kinase (AMPK) increased FTO expression, and there was a positive feedback loop between FTO and p-AMPK. p-AMPK and FTO induced mild ER stress; however, tunicamycin-induced severe ER stress suppressed FTO expression and AMPK activation. In summary, FTO induces osteogenic differentiation of C3H10T1/2 cells upon BMP2 treatment by inducing mild ER stress via a positive feedback loop with p-AMPK. FTO expression and AMPK activation induce mild ER stress. By contrast, severe ER stress inhibits osteogenic differentiation by suppressing FTO expression and AMPK activation. | Son, Hyo-Eun; Min, Hyeon-Young; Kim, Eun-Jung; Jang, Won-Gu | Daegu Univ, Sch Engn, Dept Biotechnol, Gyongsan 38453, South Korea; Daegu Univ, Res Inst AntiAging, Gyongsan 38453, South Korea; Kyungpook Natl Univ, Sch Med, Dept Immunol, Daegu 41944, South Korea | KIM, EUNJUNG/KFC-0377-2024 | 57194542768; 57190981561; 57213014281; 36948705500 | ejkim4164@knu.ac.kr;jangwg@daegu.ac.kr; | MOLECULES AND CELLS | MOL CELLS | 1016-8478 | 0219-1032 | 43 | 1 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CELL BIOLOGY | 2020 | 5.034 | 30.3 | 1 | 2025-06-25 | 26 | 27 | adenosine monophosphate-activated protein kinase; C3H10T1/2 cells; endoplasmic reticulum stress; fat mass and obesity-associated; osteoblast | BONE MORPHOGENETIC PROTEINS; OSTEOBLAST DIFFERENTIATION; EXPRESSION; GENE; RUNX2; BMP2; ACCUMULATION; OSTEOCALCIN; LIPOGENESIS; ACTIVATION | adenosine monophosphate-activated protein kinase; C3H10T1/2 cells; endoplasmic reticulum stress; fat mass and obesity-associated; osteoblast | Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Bone Morphogenetic Protein 2; Cell Differentiation; Cell Line; Core Binding Factor Alpha 1 Subunit; Endoplasmic Reticulum Stress; Feedback, Physiological; Gene Expression Regulation; Homeodomain Proteins; Humans; Mice; Obesity; Osteogenesis; Phosphorylation; Protein Kinases; RNA, Small Interfering; alpha ketoglutarate dependent dioxygenase FTO; AMP-activated protein kinase kinase; Bmp2 protein, mouse; bone morphogenetic protein 2; Dlx5 protein, mouse; FTO protein, mouse; homeodomain protein; protein kinase; small interfering RNA; transcription factor RUNX2; animal; bone development; cell differentiation; cell line; endoplasmic reticulum stress; gene expression regulation; genetics; human; metabolism; mouse; obesity; phosphorylation; physiological feedback | English | 2020 | 2020-01 | 10.14348/molcells.2019.0136 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | march5 Governs the Convergence and Extension Movement for Organization of the Telencephalon and Diencephalon in Zebrafish Embryos | MARCH5 is a RING finger E3 ligase involved in mitochondrial integrity, cellular protein homeostasis, and the regulation of mitochondrial fusion and fission. To determine the function of MARCH5 during development, we assessed transcript expression in zebrafish embryos. We found that march5 transcripts were of maternal origin and evenly distributed at the 1-cell stage, except for the mid-blastula transition, with expression predominantly in the developing central nervous system at later stages of embryogenesis. Overexpression of march5 impaired convergent extension movement during gastrulation, resulting in reduced patterning along the dorsoventral axis and alterations in the ventral cell types. Overexpression and knockdown of march5 disrupted the organization of the developing telencephalon and diencephalon. Lastly, we found that the transcription of march5 was tightly regulated by the transcriptional regulators CHOP, C/EBP alpha, Staf, Znf143a, and Znf76. These results demonstrate the essential role of March5 in the development of zebrafish embryos. | Jung, Jangham; Choi, Issac; Ro, Hyunju; Huh, Tae-Lin; Choe, Joonho; Rhee, Myungchull | Chungnam Natl Univ, Grad Sch, Dept Life Sci, BK21 Plus Program, Daejeon 34134, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci & Biotechnol, Daegu 41566, South Korea; Korea Adv Inst Sci & Technol, Dept Biol Sci, Daejeon 34141, South Korea | 57206894285; 58324011900; 7005589399; 7007119367; 56252921800; 7102347645 | mrhee@cnu.ac.kr; | MOLECULES AND CELLS | MOL CELLS | 1016-8478 | 0219-1032 | 43 | 1 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CELL BIOLOGY | 2020 | 5.034 | 30.3 | 0.38 | 2025-06-25 | 6 | 6 | convergence and extension movement; diencephalon; March5/MITOL; telencephalon; ubiquitin proteasome system | ENDOPLASMIC-RETICULUM; MITOCHONDRIAL FISSION; WILD-TYPE; EXPRESSION; GENE; PROTEIN; TRANSCRIPTION; CHOP; RNA; HINDBRAIN | convergence and extension movement; diencephalon; March5/MITOL; telencephalon; ubiquitin proteasome system | Animals; Central Nervous System; Diencephalon; Embryonic Development; Gene Knockdown Techniques; HEK293 Cells; Homeostasis; Humans; Mitochondria; Telencephalon; Ubiquitin-Protein Ligases; Ubiquitination; Zebrafish; Zebrafish Proteins; ubiquitin protein ligase; zebrafish protein; animal; central nervous system; diencephalon; embryo development; embryology; gene knockdown; genetics; HEK293 cell line; homeostasis; human; metabolism; mitochondrion; physiology; telencephalon; ubiquitination; zebra fish | English | 2020 | 2020-01 | 10.14348/molcells.2019.0210 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Mitophagy and Innate Immunity in Infection | Mitochondria have several quality control mechanisms by which they maintain cellular homeostasis and ensure that the molecular machinery is protected from stress. Mitophagy, selective autophagy of mitochondria, promotes mitochondrial quality control by inducing clearance of damaged mitochondria via the autophagic machinery. Accumulating evidence suggests that mitophagy is modulated by various microbial components in an attempt to affect the innate immune response to infection. In addition, mitophagy plays a key role in the regulation of inflammatory signaling, and mitochondrial danger signals such as mitochondrial DNA translocated into the cytosol can lead to exaggerated inflammatory responses. In this review, we present current knowledge on the functional aspects of mitophagy and its crosstalk with innate immune signaling during infection. A deeper understanding of the role of mitophagy could facilitate the development of more effective therapeutic strategies against various infections. | Cho, Dong-Hyung; Kim, Jin Kyung; Jo, Eun-Kyeong | Kyungpook Natl Univ, Sch Life Sci, Daegu 41566, South Korea; Chungnam Natl Univ, Sch Med, Dept Microbiol, Daejeon 35015, South Korea; Chungnam Natl Univ, Infect Control Convergence Res Ctr, Sch Med, Daejeon 35015, South Korea | ; Choi, Hye Rin/JDV-9065-2023 | 35093684400; 57214428258; 7003663754 | hayoungj@cnu.ac.kr; | MOLECULES AND CELLS | MOL CELLS | 1016-8478 | 0219-1032 | 43 | 1 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CELL BIOLOGY | 2020 | 5.034 | 30.3 | 5.47 | 2025-06-25 | 76 | 75 | infection; inflammation; innate immunity; mitochondria; mitophagy | MITOCHONDRIAL QUALITY-CONTROL; I INTERFERON; SELECTIVE AUTOPHAGY; PROTEIN; VIRUS; PROMOTES; ACTIVATION; RECEPTORS; FISSION; REPLICATION | Infection; Inflammation; Innate immunity; Mitochondria; Mitophagy | Animals; Autophagy; Homeostasis; Humans; Immunity, Innate; Infections; Inflammation; Mitochondria; Mitophagy; Signal Transduction; inflammasome; parkin; pink1 protein; protein; unclassified drug; fungus; Hepatitis B virus; Hepatitis C virus; human; immunoregulation; infection; inflammation; innate immunity; mitophagy; nonhuman; protein function; Short Survey; signal transduction; animal; autophagy; homeostasis; immunology; innate immunity; metabolism; mitochondrion; mitophagy | English | 2020 | 2020-01 | 10.14348/molcells.2020.2329 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Oleoylethanolamide Exhibits GPR119-Dependent Inhibition of Osteoclast Function and GPR119-Independent Promotion of Osteoclast Apoptosis | Oleoylethanolamide (OEA), a bioactive lipid in bone, is known as an endogenous ligand for G protein-coupled receptor 119 (GPR119). Here, we explored the effects of OEA on osteoclast differentiation, function, and survival. While OEA inhibits osteoclast resorptive function by disrupting actin cytoskeleton, it does not affect receptor activator of nuclear factor-.B ligand ( RANKL)-induced osteoclast differentiation. OEA attenuates osteoclast spreading, blocks actin ring formation, and eventually impairs bone resorption. Mechanistically, OEA inhibits Rac activation in response to macrophage colony-stimulating factor (M-CSF), but not RANKL. Furthermore, the OEA-mediated cytoskeletal disorganization is abrogated by GPR119 knockdown using small hairpin RNA (shRNA), indicating that GPR119 is pivotal for osteoclast cytoskeletal organization. In addition, OEA induces apoptosis in both control and GPR119 shRNA-transduced osteoclasts, suggesting that GPR119 is not required for osteoclast apoptosis. Collectively, our findings reveal that OEA has inhibitory effects on osteoclast function and survival of mature osteoclasts via GPR119-dependent and GPR119-independent pathways, respectively. | Kim, Hyun-Ju; Lee, Dong-Kyo; Jin, Xian; Che, Xiangguo; Choi, Je-Yong | Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Biochem & Cell Biol,BK21 Plus KNU Biomed Con, Daegu 41944, South Korea | Choi, Je-Yong/AAR-7334-2021 | 57208650339; 57216603928; 57204810645; 54792660600; 7501391068 | biohjk@knu.ac.kr;jechoi@knu.ac.kr; | MOLECULES AND CELLS | MOL CELLS | 1016-8478 | 0219-1032 | 43 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CELL BIOLOGY | 2020 | 5.034 | 30.3 | 0.38 | 2025-06-25 | 6 | 6 | apoptosis; cytoskeleton; G protein-coupled receptor 119; oleoylethanolamide; osteoclast | PROTEIN-COUPLED RECEPTOR; CANNABINOID RECEPTOR; BONE MASS; IN-VITRO; DIFFERENTIATION; GLUCOCORTICOIDS; ORGANIZATION; INVOLVEMENT; ACTIVATION; RESORPTION | Apoptosis; Cytoskeleton; G protein-coupled receptor 119; Oleoylethanolamide; Osteoclast | Apoptosis; Cell Differentiation; Endocannabinoids; Humans; Oleic Acids; Osteoclasts; colony stimulating factor 1; G protein coupled receptor; G protein coupled receptor 119; n oleoylethanolamine; osteoclast differentiation factor; Rac protein; short hairpin RNA; unclassified drug; endocannabinoid; n oleoylethanolamine; oleic acid; actin filament; animal cell; apoptosis; Article; cell function; cell survival; controlled study; cytoskeleton; enzyme activation; gene knockdown; genetic transduction; mouse; nonhuman; osteoclast; osteoclastogenesis; osteolysis; apoptosis; cell differentiation; drug effect; human; metabolism; osteoclast | English | 2020 | 2020-04 | 10.14348/molcells.2020.2260 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | PRP4 Kinase Domain Loss Nullifies Drug Resistance and Epithelial-Mesenchymal Transition in Human Colorectal Carcinoma Cells | We have investigated the involvement of the pre-mRNA processing factor 4B (PRP4) kinase domain in mediating drug resistance. HCT116 cells were treated with curcumin, and apoptosis was assessed based on flow cytometry and the generation of reactive oxygen species (ROS). Cells were then transfected with PRP4 or pre-m RNA-processing-splicing factor 8 (PRP8), and drug resistance was analyzed both in vitro and in vivo. Furthermore, we deleted the kinase domain in PRP4 using Gateway (TM) technology. Curcumin induced cell death through the production of ROS and decreased the activation of survival signals, but PRP4 overexpression reversed the curcumin-induced oxidative stress and apoptosis. PRP8 failed to reverse the curcumin-induced apoptosis in the HCT116 colon cancer cell line. In xenograft mouse model experiments, curcumin effectively reduced tumour size whereas PRP4 conferred resistance to curcumin, which was evident from increasing tumour size, while PRP8 failed to regulate the curcumin action. PRP4 overexpression altered the morphology, rearranged the actin cytoskeleton, triggered epithelial-mesenchymal transition (EMT), and decreased the invasiveness of HCT116 cells. The loss of E-cadherin, a hallmark of EMT, was observed in HCT116 cells overexpressing PRP4. Moreover, we observed that the EMT-inducing potential of PRP4 was aborted after the deletion of its kinase domain. Collectively, our investigations suggest that the PRP4 kinase domain is responsible for promoting drug resistance to curcumin by inducing EMT. Further evaluation of PRP4-induced inhibition of cell death and PRP4 kinase domain interactions with various other proteins might lead to the development of novel approaches for overcoming drug resistance in patients with colon cancer. | Ahmed, Muhammad Bilal; Ul Islam, Salman; Sonn, Jong Kyung; Lee, Young Sup | Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Dept Biol, Daegu 41566, South Korea | 58689879600; 56985186700; 35580853300; 36013628200 | yselee@knu.ac.kr; | MOLECULES AND CELLS | MOL CELLS | 1016-8478 | 0219-1032 | 43 | 7 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CELL BIOLOGY | 2020 | 5.034 | 30.3 | 0.44 | 2025-06-25 | 9 | 9 | colorectal cancer; curcumin; EMT; HCT116; kinase domain; PRP4; PRP8 | CHEMORESISTANCE; CONTRIBUTES; METASTASIS; EXPRESSION; APOPTOSIS; GENES | Colorectal cancer; Curcumin; EMT; HCT116; Kinase domain; PRP4; PRP8 | Actin Cytoskeleton; Animals; Apoptosis; Cadherins; Catalytic Domain; Colorectal Neoplasms; Curcumin; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; HCT116 Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Oxidative Stress; Protein-Serine-Threonine Kinases; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Ribonucleoprotein, U4-U6 Small Nuclear; RNA-Binding Proteins; Up-Regulation; Xenograft Model Antitumor Assays; blood clotting factor 8; curcumin; messenger RNA precursor; phosphotransferase; processing factor 4B kinase; reactive oxygen metabolite; unclassified drug; uvomorulin; cadherin; curcumin; protein serine threonine kinase; PRPF4B protein, human; PRPF8 protein, human; reactive oxygen metabolite; RNA binding protein; small nuclear ribonucleoprotein; actin filament; adult; animal experiment; animal model; animal tissue; apoptosis; Article; cancer resistance; cancer size; cancer survival; colorectal carcinoma; controlled study; deletion mutant; epithelial mesenchymal transition; flow cytometry; gene deletion; gene overexpression; gene rearrangement; HCT 116 cell line; human; human cell; in vitro study; in vivo study; male; mouse; nonhuman; oxidative stress; protein domain; protein expression; RNA splicing; signal transduction; tumor xenograft; animal; Bagg albino mouse; colorectal tumor; drug effect; drug resistance; drug screening; enzyme active site; epithelial mesenchymal transition; genetics; metabolism; nude mouse; real time polymerase chain reaction; upregulation | English | 2020 | 2020-07 | 10.14348/molcells.2020.2263 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Deep Learning Based Real-Time OCT Image Segmentation and Correction for Robotic Needle Insertion Systems | This article proposes deep learning based real-time optical coherence tomography (OCT) image segmentation and correction algorithm for vision-based robotic needle insertion systems that can be used in DALK (deep anterior lamellar keratoplasty) surgery. The proposed algorithm provides the position of the needle tip, the lower boundary of the tissue, and the marginal insertion depth solving traditional issues of OCT images like refractive error, optical noise from surgical tools, and the slow speed of volumetric scanning. Through the ex-vivo experiment using 10 porcine corneas, the performance of the proposed algorithm with a robotic system was verified. The segmentation errors were 7.4 mu m for the upper boundary, 10.5 mu m for the lower boundary, and 3.6 mu m for the needle tip. The difference in needle slope between the outside and inside of the cornea was dramatically reduced from 5.87 degree to 0.78 degree. The frame rate of the OCT image was 9.7 Hz, and the time delay of the image processing algorithm was 542.6 ms for 10 images of 512 x 512 pixels. The results of the proposed algorithm were compared with those of the previous studies. | Park, Ikjong; Kim, Hong-Kyun; Chung, Wan Kyun; Kim, Keehoon | POSTECH, Dept Mech Engn, Pohang 790784, South Korea; Kyungpook Natl Univ Hosp, Dept Ophthalmol, Daegu 700721, South Korea | 57192195676; 57218260940; 57204958534; 59475350100 | tool213@postech.ac.kr;okeye@knu.ac.kr;wkchung@postech.ac.kr;khk@postech.ac.kr; | IEEE ROBOTICS AND AUTOMATION LETTERS | IEEE ROBOT AUTOM LET | 2377-3766 | 5 | 3 | SCIE | ROBOTICS | 2020 | 3.741 | 30.4 | 0.57 | 2025-06-25 | 17 | 16 | Automation in life sciences; biotechnology; pharmaceutical and health care | OPTICAL COHERENCE TOMOGRAPHY; ANTERIOR SEGMENT; OPHTHALMIC SURGERY | Automation in life sciences: biotechnology; pharmaceutical and health care | Agricultural robots; Image segmentation; Learning systems; Needles; Optical data processing; Optical tomography; Real time systems; Robotic surgery; Robotics; Surgery; Surgical equipment; Correction algorithms; Image processing algorithm; Insertion depth; Porcine corneas; Refractive error; Robotic needle insertion; Segmentation error; Volumetric scanning; Deep learning | English | 2020 | 2020-07 | 10.1109/lra.2020.3001474 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Detecting Conditional Dependence Using Flexible Bayesian Latent Class Analysis | A fundamental assumption underlying latent class analysis (LCA) is that class indicators are conditionally independent of each other, given latent class membership. Bayesian LCA enables researchers to detect and accommodate violations of this assumption by estimating any number of correlations among indicators with proper prior distributions. However, little is known about how the choice of prior may affect the performance of Bayesian LCA. This article presents a Monte Carlo simulation study that investigates (1) the utility of priors in a range of prior variances (i.e., strongly non-informative to strongly informative priors) in terms of Type I error and power for detecting conditional dependence and (2) the influence of imposing approximate independence on model fit of Bayesian LCA. Simulation results favored the use of a weakly informative prior with large variance-model fit (posterior predictive p-value) was always satisfactory when the class indicators were either independent or dependent. Based on the current findings and the additional literature, this article offers methodological guidelines and suggestions for applied researchers. | Lee, Jaehoon; Jung, Kwanghee; Park, Jungkyu | Texas Tech Univ, Dept Educ Psychol & Leadership, Lubbock, TX 79409 USA; Kyungpook Natl Univ, Dept Psychol, Daegu, South Korea | ; Jung, Kwanghee/ABB-1639-2020 | 55319562000; 56352044200; 56206565000 | kwanghee.jung@ttu.edu;jkp@knu.ac.kr; | FRONTIERS IN PSYCHOLOGY | FRONT PSYCHOL | 1664-1078 | 11 | SSCI | PSYCHOLOGY, MULTIDISCIPLINARY | 2020 | 2.988 | 30.4 | 0.74 | 2025-06-25 | 15 | 15 | conditional dependence; Bayesian latent class analysis; approximate independence; prior variance; model fit | MIXTURE-MODELS; VARIABLES | approximate independence; Bayesian latent class analysis; conditional dependence; model fit; prior variance | English | 2020 | 2020-08-06 | 10.3389/fpsyg.2020.01987 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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