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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | Article | Frequency-specific neuromuscular adaptations: comparative effects of high- and low-frequency neuromuscular electrical stimulation on muscle function and quality | This study investigated the frequency-specific effects of high-and low-frequency neuromuscular electrical stimulation (NMES) on neuromuscular function and muscle quality. Sixteen healthy young males were randomly assigned to either a high-frequency stimulation group (HFES, 100 Hz; n= 8) or a low-frequency stimulation group (LFES, 50 Hz; n= 8) for 6 weeks of NMES intervention. Neuromuscular function was assessed using maximum voluntary isometric contraction (MVIC), while muscle quality of the rectus femoris (RF) and vastus lateralis (VL) was evaluated via ultrasound echo intensity (EI). Assessments were taken at baseline, midintervention (week 3), and postintervention (weeks 6, 8 and 10). HFES significantly increased MVIC during the intervention, indicating an immediate neuromuscular improvement. In contrast, LFES showed delayed effects, with significant EI improvements in RF and VL emerging only after the intervention ended. Statistical analysis revealed significant interaction effect between time and intervention for MVIC and EI, highlighting the frequency-dependent nature of NMES adaptations. These results suggest that NMES induces neuromuscular adaptations in healthy adult males, with HFES promoting immediate gains and LFES leading to delayed benefits. Thus, frequency selection is critical in designing effective NMES protocols. | Jo, Hyeon-Deok; Kim, Maeng-Kyu | Kyungpook Natl Univ, Sports Sci Res Inst, Daegu, South Korea; Kyungpook Natl Univ, Sports Med Lab, Dept Phys Educ, Daegu, South Korea | kimmk@knu.ac.kr; | JOURNAL OF EXERCISE REHABILITATION | J EXERC REHABIL | 2288-176X | 2288-1778 | 21 | 3 | ESCI | REHABILITATION | 2024 | 1.6 | 43.1 | 0 | Neuromuscular electrical stimulation; Stimulation frequency; Neuromuscular function; Muscle quality; Echo intensity | HUMAN SKELETAL-MUSCLE; CONTRACTIONS; STRENGTH | English | 2025 | 2025-06 | 10.12965/jer.2550222.111 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Serum 25-Hydroxyvitamin D Levels and Survival Outcomes in Advanced Biliary Tract Cancer: Results From the NIFTY Trial | BackgroundNumerous studies have explored the role of vitamin D in various cancers; however, its impact on advanced biliary tract cancers (BTC) within a prospective cohort remains to be investigated. This preplanned subgroup analysis of the NIFTY trial evaluated the prognostic implications of serum vitamin D levels in patients with advanced BTC undergoing second-line chemotherapy.MethodsFrom the 174 patients in the NIFTY trial, a total of 173 patients (99.4%) were included in this analysis comparing a liposomal irinotecan plus 5-FU/leucovorin group (n = 87) and a 5-FU/leucovorin alone group (n = 86). Baseline serum 25-hydroxyvitamin D (25(OH)D) levels, an indicator of vitamin D status, were analyzed for their association with baseline characteristics and overall survival (OS) in patients undergoing second-line chemotherapy. Multivariable Cox proportional hazards regression and a restricted cubic spline function were used to assess the association with OS.ResultsThere were no significant associations between baseline characteristics and serum 25(OH)D levels. Baseline serum 25(OH)D levels were not associated with OS in either the multivariable Cox proportional hazard regression or restricted cubic spline analysis. In the subgroup analysis, however, higher serum 25(OH)D levels were significantly associated with poorer OS in female patients, while no significant association was observed in male patients, indicating a significant interaction by sex. Additionally, a marginally significant interaction was observed between body mass index and serum 25(OH)D levels for OS, with higher levels associated with better OS in patients who were underweight.ConclusionsOur preplanned subgroup analysis of the NIFTY trial indicates that the serum 25(OH)D levels did not have a significant effect on OS in the overall patient population with advanced BTC. However, higher serum 25(OH)D levels were associated with worse OS in female patients, underscoring the need for further investigation into the role of vitamin D in BTC. | Lee, So Heun; Cheon, Jaekyung; Kim, Ilhwan; Kim, Kyu-pyo; Ryoo, Baek-Yeol; Jeong, Jae Ho; Kang, Myoung Joo; Kang, Byung Woog; Ryu, Hyewon; Lee, Ji Sung; Yoo, Changhoon | Univ Ulsan, Coll Med, Asan Med Ctr, Dept Oncol, Seoul, South Korea; Chung Ang Univ, Gwangmyeong Hosp, Div Hematol Oncol, Coll Med, Gwangmyeong, South Korea; Inje Univ, Coll Med, Dept Internal Med, Haeundae Paik Hosp,Div Oncol, Busan, South Korea; Kyungpook Natl Univ, Sch Med, Kyungpook Natl Univ Med Ctr, Dept Oncol Hematol, Daegu, South Korea; Chungnam Natl Univ Hosp, Dept Internal Med, Div Hematol & Oncol, Daejeon, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Asan Inst Life Sci,Clin Res Ctr, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Clin Epidemiol & Biostat, Seoul, South Korea | Lee, So Heun/KHW-8032-2024 | 57695620000; 57203287161; 57202402657; 7409319176; 6603026326; 57022763500; 57190689321; 28567838500; 56075661600; 57217244570; 22954694200 | jisung.lee@amc.seoul.kr; yooc@amc.seoul.kr; | CANCER MEDICINE | CANCER MED-US | 2045-7634 | 14 | 1 | SCIE | ONCOLOGY | 2024 | 3.1 | 43.1 | 0 | 2025-05-07 | 0 | 0 | biliary tract cancer; NIFTY trial; overall survival; vitamin D | VITAMIN-D STATUS; METASTATIC COLORECTAL-CANCER; D DEFICIENCY; CHOLANGIOCARCINOMA; SUPPLEMENTATION; PREVENTION; BIOMARKER; RISK | biliary tract cancer; NIFTY trial; overall survival; vitamin D | Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neoplasms; Female; Fluorouracil; Humans; Irinotecan; Male; Middle Aged; Neoplasm Staging; Prognosis; Proportional Hazards Models; Treatment Outcome; Vitamin D; 25 hydroxyvitamin D; alpha tocopherol; cisplatin; fluorouracil; folinic acid; irinotecan; levoleucovorin; oxaliplatin; vitamin D receptor; 25-hydroxyvitamin D; antineoplastic agent; fluorouracil; irinotecan; vitamin D; adult; aged; apoptosis; Article; biliary tract cancer; body mass; bone metabolism; breast cancer; cancer mortality; cancer prognosis; cell proliferation; clinical outcome; colon cancer; CpG island; diet supplementation; drug efficacy; drug interaction; female; gallbladder cancer; gene expression; human; immunomodulation; intracellular signaling; liquid chromatography-mass spectrometry; liver metastasis; lung cancer; major clinical study; male; metastasis; obesity; overall survival; postmenopause; progression free survival; prospective study; radiation exposure; radiosensitivity; risk factor; stomach cancer; Student t test; tumor growth; vitamin blood level; biliary tract tumor; blood; cancer staging; drug therapy; middle aged; mortality; prognosis; proportional hazards model; treatment outcome | English | 2025 | 2025-01 | 10.1002/cam4.70560 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Guillain-Barre syndrome during the COVID-19 era: A nationwide study of hospitalized cases in South Korea | This study aimed to analyze the trends and characteristics of hospitalized Guillain-Barre syndrome (GBS) incidence and management in South Korea before and during the coronavirus disease 2019 pandemic, assessing potential impacts of nonpharmaceutical interventions and shifts in public health dynamics. We conducted a retrospective analysis using data from the Health Insurance Review and Assessment Service database from 2013 to 2021, divided into prepandemic (2013-2019) and pandemic (2020-2021) periods. Incident GBS cases were identified based on the G61.0 code with hospital admissions. A total of 10,596 hospitalized patients with GBS were identified, with 8537 cases in the prepandemic period and 2059 during the pandemic. While the overall GBS incidence did not show a statistically significant change during the pandemic (P = .056), the mean age of patients increased. Notably, a significant rise in the proportion of patients receiving intravenous immunoglobulin was observed during the pandemic (P < .001), with older patients showing higher mean ages (P = .007). However, the proportion of patients requiring mechanical ventilation remained stable (P = .240). The findings suggest that while hospitalized GBS incidence remained stable amidst the pandemic and reduced respiratory infection admissions, the increase in intravenous immunoglobulin use points to more severe presentations, particularly among older patients. This highlights the multifactorial nature of GBS triggers and the need for continued investigation into how evolving public health measures and infectious disease patterns influence GBS incidence and management. | Park, Jin-Mo; Bae, Jong-Sup | Kyungpook Natl Univ, Pharmaceut Sci Res Inst, CMRI, Coll Pharm, 80 Daehak Ro, Taegu 41566, South Korea; Dongguk Univ, Gyeongju Hosp, Dept Neurol, Coll Med, Gyeongju, South Korea | 55569003000; 16021543200 | neuropjm@gmail.com; baejs@knu.ac.kr; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 104 | 8 | SCIE | MEDICINE, GENERAL & INTERNAL | 2024 | 1.4 | 43.2 | 0 | 2025-05-07 | 0 | 0 | COVID-19; Guillain-Barre syndrome; GBS; HIRA; Korea | COVID-19; GBS; Guillain-Barré syndrome; HIRA; Korea | Adolescent; Adult; Aged; Aged, 80 and over; COVID-19; Female; Guillain-Barre Syndrome; Hospitalization; Humans; Immunoglobulins, Intravenous; Incidence; Male; Middle Aged; Republic of Korea; Respiration, Artificial; Retrospective Studies; SARS-CoV-2; Young Adult; immunoglobulin; immunoglobulin; adult; age distribution; Article; artificial ventilation; cohort analysis; controlled study; coronavirus disease 2019; female; Guillain Barre syndrome; hospital admission; hospital patient; human; incidence; major clinical study; male; middle aged; pandemic; public health; respiratory tract infection; retrospective study; sex difference; South Korea; adolescent; aged; coronavirus disease 2019; epidemiology; Guillain Barre syndrome; hospitalization; Severe acute respiratory syndrome coronavirus 2; very elderly; young adult | English | 2025 | 2025-02-21 | 10.1097/md.0000000000041677 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Hydrogen-rich electrolyzed water is a useful mouthwash due to its biofilm-control properties: an in vitro and in vivo study | Background: Previous studies have demonstrated the inhibitory effect of hydrogen-rich water on biofilm formation. However, hydrogen-rich electrolyzed water (HEW) has not been evaluated as mouthwash, despite being economical, convenient, and biologically safe. We assessed the antibiofilm effects of HEW on Streptococcus mutans and its potential as a mouthwash. Methods: The effect of HEW on S. mutans growth was assessed by measuring bacterial colony-forming units, and biofilm formation capacity was examined by crystal violet staining after culturing on a polystyrene plate. The effect of HEW on biofilm formation-related gene expression in S. mutans was assessed by real-time polymerase chain reaction. Finally, the effect of HEW on salivary S. mutans and plaque maturation was evaluated in 24 participants; after gargling with HEW twice daily, the salivary S. mutans count was quantified using a Caries Risk Test bacteria kit (Ivoclar Vivadent AG), and plaque maturation was compared using quantitative light-induced fluorescence imaging. Results: Exposure to HEW resulted in no significant changes in S. mutans growth but a significant reduction in biofilm formation in vitro (p<0.001). Furthermore, the gene expression of glucosyltransferases (gtfB, gtfC) was significantly lower than that in the control group treated with tap water (p<0.05, p<0.01). S. mutans counts and plaque maturation were significantly lower in participants who gargled with HEW than in those who gargled with tap water (p<0.01). Conclusion: Our data suggest that oral rinsing with HEW exerts antibiofilm effects on S. mutans, indicating that it can be used as a mouthwash to treat dental biofilm-dependent diseases. © 2025 Yeungnam University College of Medicine, Yeungnam University Institute of Medical Science. | Youn, Ha-Young; Kim, Ji-Hye; Cho, Min-Jeong; Hong, Su-Hyung; Kim, Eun-Kyong | Department of Preventive Dentistry, School of Dentistry, Kyungpook National University, Daegu, South Korea; Department of Preventive Dentistry, School of Dentistry, Kyungpook National University, Daegu, South Korea; Department of Preventive Dentistry, School of Dentistry, Kyungpook National University, Daegu, South Korea; Department of Oral Microbiology and Immunology, School of Dentistry, Kyungpook National University, Daegu, South Korea; Department of Preventive Dentistry, School of Dentistry, Kyungpook National University, Daegu, South Korea | 59949003900; 58099706300; 57201842940; 8691449100; 55915892100 | ekkim99@knu.ac.kr; | Journal of Yeungnam Medical Science | J YEUNGNAM MED SCI | N/A | 2799-8010 | 42 | ESCI | MEDICINE, GENERAL & INTERNAL | 2024 | 1.4 | 43.2 | N/A | 0 | Biofilms; Dental caries; Electrolysis; Hydrogen; Mouthwashes | English | Final | 2025 | 10.12701/jyms.2025.42.34 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Incarcerated hiatal hernia with afferent loop syndrome after laparoscopic total gastrectomy with Roux-en-Y reconstruction: A rare case report | Rationale: Hiatal hernia is one of the rarest types of internal herniation that can occur after gastrectomy. We present a case of hiatal hernia accompanied with afferent loop syndrome. Patient concerns: An 82-year-old male, who had undergone laparoscopic total gastrectomy and D2 lymphadenectomy with Roux-en-Y reconstruction 10 months prior was admitted to the emergency room with acute abdominal pain. Diagnoses: A computed tomography revealed a hiatal hernia containing efferent and left-sided small bowel loops, dilation of the afferent limb, and dilation of the extrahepatic biliary duct due to afferent limb obstruction. Interventions: Laparoscopic reduction was significantly hindered by bowel edema. To ease the reduction of the small bowel, an incision was made to the diaphragm to ensure a bigger hiatal opening. After the reduction was complete, the hiatal opening was sutured to reduce the size of the diaphragmatic hiatus. Outcomes: Reduced small bowels were in viable condition. The patient was discharged eleven days after surgery without any complications. Lessons: The case demonstrates that hiatal hernia with afferent loop syndrome can occur after total gastrectomy with Roux-en-Y reconstruction. And, in such cases, incision of the diaphragm may be necessary for a safer bowel reduction. | Shin, Hyun Wook; Park, Ki Bum | Kyungpook Natl Univ, Dept Surg, Chilgok Hosp, 807 Hoguk Ro, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea | 57721030500; 57220965452 | ronhshin@gmail.com; parkeagle82@knu.ac.kr; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 104 | 22 | SCIE | MEDICINE, GENERAL & INTERNAL | 2024 | 1.4 | 43.2 | 0 | 2025-06-11 | 0 | 0 | afferent loop syndrome; gastrectomy; hiatal hernia | INTERNAL HERNIA | afferent loop syndrome; gastrectomy; hiatal hernia | Afferent Loop Syndrome; Aged, 80 and over; Anastomosis, Roux-en-Y; Gastrectomy; Hernia, Hiatal; Humans; Laparoscopy; Male; Postoperative Complications; Tomography, X-Ray Computed; abdominal pain; acute abdomen; afferent loop syndrome; aged; Article; cancer surgery; case report; clinical article; computer assisted tomography; emergency ward; follow up; hiatus hernia; hospital admission; human; incision; intensive care unit; jejunojejunostomy; laparoscopic total gastrectomy; lymph node dissection; male; postoperative period; Roux-en-Y gastric bypass; small intestinal loop; stomach cancer; thorax radiography; tumor recurrence; very elderly; adverse event; afferent loop syndrome; diagnostic imaging; etiology; gastrectomy; hiatus hernia; laparoscopy; postoperative complication; procedures; Roux Y anastomosis; surgery; x-ray computed tomography | English | 2025 | 2025-05-30 | 10.1097/md.0000000000042525 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Ischemic monomelic neuropathy following arteriovenous fistula surgery: a case report | Ischemic monomelic neuropathy (IMN) is an uncommon complication of arteriovenous fistula (AVF) surgery that presents with pain, motor weakness, and sensory changes without critical ischemia. This report describes a rare case of successful IMN treatment after AVF surgery. A 61-year-old man with diabetic end-stage kidney disease was admitted for left brachiocephalic AVF surgery. Postoperatively, the patient complained of pain, motor weakness, and numbness in the left hand. However, the radial pulse remained palpable, and the overlying skin remained intact. A nerve conduction study above the wrist revealed reduced compound muscle action potential (CMAP) of the left ulnar nerve and no CMAP of the left median nerve. This study also showed the absence of sensory amplitude in both the left median and left ulnar nerves. Therefore, the patient was diagnosed with IMN. Proximalization of the arterial inflow surgery was performed to redistribute blood flow while maintaining the AVF. The patient's neurological symptoms resolved postoperatively. Various conditions can cause hand pain after AVF surgery; however, IMN has rarely been reported. A multidisciplinary approach is needed to avoid this rare complication in patients presenting with hand pain after AVF surgery. | Kim, Da Woon; Jeon, You Hyun; Bae, Miju; Song, Sang Heon | Pusan Natl Univ Hosp, Dept Internal Med, 179 Gudeok Ro, Pusan 49241, Guam, South Korea; Pusan Natl Univ Hosp, Biomed Res Inst, Pusan, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Nephrol, Daegu, South Korea; Pusan Natl Univ Hosp, Dept Thorac & Cardiovasc Surg, Pusan, South Korea; Pusan Natl Univ, Sch Med, Dept Internal Med, Yangsan, South Korea | 57214248568; 57820096000; 59761456500; 59710844300 | shsong0209@gmail.com; | JOURNAL OF YEUNGNAM MEDICAL SCIENCE | J YEUNGNAM MED SCI | 2799-8010 | 42 | ESCI | MEDICINE, GENERAL & INTERNAL | 2024 | 1.4 | 43.2 | N/A | 0 | 0 | Arteriovenous fistula; Ischemic monomelic neuropathy; Steal phenomenon; Vascular access | Arteriovenous fistula; Ischemic monomelic neuropathy; Steal phenomenon; Vascular access | English | 2025 | 2025 | 10.12701/jyms.2024.00948 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Nasopharyngeal tuberculosis suspected of malignancy: A case report | Rationale:Nasopharyngeal tuberculosis (TB), a rare form of tuberculosis outside the lungs, can affect any organ or tissue in the body. It is difficult to diagnose because of nonspecific symptoms, often leading to delayed confirmation after the initial patient visit. Clinical manifestations such as cervical lymphadenopathy and irregular mucosal surfaces can be challenging to distinguish from nasopharyngeal cancer or malignant lymphoma.Patient concerns:In this case report, we present a patient initially suspected of having a malignant disease based on abnormal nasopharyngeal imaging findings.Diagnoses:Further examination revealed chronic granulomatous inflammation, and subsequent tuberculosis polymerase chain reaction (TB-PCR) confirmed the diagnosis of tuberculosis.Interventions:The patient is currently receiving anti-TB treatment with a 4-drug regimen, which has shown a good response with continuous reduction in lesion size.Outcomes:After anti-TB treatment, the lesion size gradually decreased and continued to decrease, showing a significant response.Lessons:Awareness and precise evaluation are key to avoiding misdiagnosis, particularly when confronted with diverse clinical presentations. Extrapulmonary tuberculosis, although relatively rare, presents unique diagnostic challenges. Nasopharyngeal tuberculosis, in particular, lacks a definitive diagnostic method, often necessitating a combination of clinical suspicion, imaging studies, microbiological tests, and histopathological examination for confirmation. The absence of specific symptoms and the variability in presentation further compound the diagnostic dilemma. Given the potential consequences of misdiagnosis, further exploration and discussion on this issue are warranted. Enhanced awareness among healthcare providers, coupled with advancements in diagnostic modalities, are essential in ensuring timely and accurate differentiation between nasopharyngeal malignancies and tuberculosis, thereby facilitating appropriate management and improving patient outcomes. | Chung, Da Hyun; Lee, Gil Joon | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Daegu, South Korea | 59185055300; 57193082568 | sidsira@naver.com; giljoon.lee@gmail.com; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 104 | 2 | SCIE | MEDICINE, GENERAL & INTERNAL | 2024 | 1.4 | 43.2 | 0 | 2025-05-07 | 0 | 0 | lymph node; lymphoma; nasopharyngeal cancer; nasopharyngeal disease; nasopharyngeal neoplasm; nasopharynx; TB-PCR; tuberculosis | lymph node; lymphoma; nasopharyngeal cancer; nasopharyngeal disease; nasopharyngeal neoplasm; nasopharynx; TB-PCR; tuberculosis | Antitubercular Agents; Diagnosis, Differential; Humans; Male; Middle Aged; Nasopharyngeal Diseases; Nasopharyngeal Neoplasms; Tuberculosis; ethambutol; fluorodeoxyglucose f 18; pyrazinamide; pyridoxine; rifampicin; tuberculostatic agent; adult; Article; bronchoscopy; case report; cervical lymph node; clinical article; computer assisted tomography; extrapulmonary tuberculosis; fine needle aspiration biopsy; follow up; granulomatous inflammation; histopathology; human; human tissue; hypertrophy; immunohistochemistry; laryngoscopy; male; middle aged; nasopharyngoscopy; nasopharynx cancer; needle biopsy; nested polymerase chain reaction; palatine tonsil; pharynx disease; polymerase chain reaction; positron emission tomography-computed tomography; treatment response; diagnosis; differential diagnosis; drug therapy; microbiology; nasopharynx tumor; pharynx disease; tuberculosis | English | 2025 | 2025-01-10 | 10.1097/md.0000000000040920 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Surgical removal of ingested magnets in children: A retrospective clinical analysis of 16 patients and review of the literature | Foreign body ingestion is a common pediatric emergency. Notably, the inadvertent ingestion of magnets is frequently initially asymptomatic, only to be detected days later when gastrointestinal damage has already manifested. We conducted a retrospective review of the medical records of 16 pediatric patients who underwent surgical removal of ingested magnets at our hospital between January 2018 and December 2023. This review encompassed the patients' demographic characteristics, the interval from ingestion to admission, clinical presentation, diagnostic techniques, the type and number of ingested magnets, location of injury, surgical interventions, and postoperative outcomes. The study sample comprised 11 boys and 5 girls, with a median age of 3.6 years (range, 1-14 years). The predominant presenting symptoms were abdominal pain (n = 6), abdominal pain accompanied by vomiting (n = 3), and a combination of fever, diarrhea, and seizure (n = 1); 6 patients were asymptomatic. Neodymium bead magnets were the most commonly ingested type, noted in 13 patients. All 16 patients underwent either laparoscopic exploration or laparotomy due to clinical deterioration or confirmed complications. For 13 patients, magnet removal with primary bowel repair was performed, whereas in 3 patients, magnet removal combined with segmental resection and primary bowel repair was necessary. Fifteen of the 16 patients recovered without complications; however, wound infections occurred in 2 patients, and 1 patient required adhesiolysis and segmental resection of the jejunum due to intestinal obstruction. One patient died of septic shock. The 15 surviving patients are currently in excellent condition. Magnet ingestion by children, particularly when multiple magnets are involved, constitutes a surgical emergency. Timely identification and prompt surgical intervention are critical to preventing severe complications. Improved educational and preventive strategies (including public awareness initiatives regarding the hazards of small magnets) are essential to reducing the frequency of these incidents. | Kwon, Hyung Jun; Park, Jinyoung | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Surg, Daegu, South Korea | 57199757347; 57190865032 | kwonhj95@knu.ac.kr; kpnugs@knu.ac.kr; | MEDICINE | MEDICINE | 0025-7974 | 1536-5964 | 104 | 24 | SCIE | MEDICINE, GENERAL & INTERNAL | 2024 | 1.4 | 43.2 | 0 | 0 | children; magnet ingestion; surgery | MANAGEMENT | children; magnet ingestion; surgery | Abdominal Pain; Adolescent; Child; Child, Preschool; Female; Foreign Bodies; Humans; Infant; Laparoscopy; Magnets; Male; Retrospective Studies; abdominal pain; adolescent; adverse event; child; complication; etiology; female; foreign body; human; infant; laparoscopy; magnet; male; preschool child; procedures; retrospective study; surgery | English | 2025 | 2025-06-13 | 10.1097/md.0000000000042903 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | Novel insights into Bacillus thuringiensis: Beyond its role as a bioinsecticide | This review explores the diverse applications of Bacillus thuringiensis (Bt) beyond its traditional role as a bioinsecticide. Bt produces a variety of compounds with distinct chemical structures and biological activities. These include antimicrobial agents effective against plant pathogens and bioactive compounds that promote plant growth through the production of siderophores, hormones, and enzymes. Additionally, Bt's industrial potential is highlighted, encompassing biofuel production, bioplastics, nanoparticle synthesis, food preservation, anticancer therapies, and heavy metal bioremediation. This critical analysis emphasizes recent advancements and applications, providing insights into Bt's role in sustainable agriculture, biotechnology, and environmental management. | Jouzani, Gholamreza Salehi; Sharafi, Reza; Argentel-Martinez, Leandris; Penuelas-Rubio, Ofelda; Ozkan, Ceyda; Incegul, Bengisu; Goksu, Rana; Hayta, Zehra; Yilki, Deniz; Yazici, Beyza; Hancer, Vildan; Sansinenea, Estibaliz; Shin, Jae-Ho; El-Shabasy, A.; Azizoglu, Ugur | Agr Res Educ & Extens Org AREEO, Agr Biotechnol Res Inst Iran ABRII, Microbial Biotechnol Dept, Fahmideh Blvd, Karaj, Iran; Agr Res Educ & Extens Org AREEO, Natl Ctr Genet Resources Agr & Nat Resources, Crop & Hort Sci Res Dept, Fahmideh Blvd, Karaj, Iran; Natl Technol Inst Mexico, Technol Inst Yaqui Valley, Dept Engn, Bacum, Sonora, Mexico; Abdullah Gul Univ, Fac Life & Nat Sci, Mol Biol & Genet Dept, Kayseri, Turkiye; Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, Puebla 72570, Pue, Mexico; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, Daegu 41566, South Korea; Jazan Univ, Coll Sci, Dept Biol, POB 114, Jazan 45142, Saudi Arabia; Kayseri Univ, Safiye Cikrikcioglu Vocat Coll, Dept Crop & Anim Prod, Kayseri, Turkiye; Erciyes Univ, Genome & Stem Cell Res Ctr, Kayseri, Turkiye | El-shabasy, Ahmed/AAM-7532-2021; Sansinenea, Estibaliz/M-6871-2019; Argentel, Leandris/AAQ-7171-2021; Peñuelas-Rubio, Ofelda/GQB-5410-2022; sharfi, reza/NBX-2659-2025; shin, Jaeho/K-6792-2013; Azizoglu, Ugur/ABC-7831-2020 | 57395958100; 57218789290; 57202038750; 57194395312; 59477307700; 59477307800; 59476659300; 59476784300; 59477307900; 59476659400; 59476659500; 56013605400; 57224125922; 57220153839; 52363128100 | gsalehi@abrii.ac.ir; azizoglugur@gmail.com; azizogluugur@hotmail.com; | RESEARCH IN MICROBIOLOGY | RES MICROBIOL | 0923-2508 | 1769-7123 | 176 | 3-4 | SCIE | MICROBIOLOGY | 2024 | 3.4 | 43.3 | 0 | 2025-05-07 | 0 | 0 | Anticancer activities; Bacillus thuringiensis; Bioplastic; Food preservation; Nanoparticles biosynthesis; Plant growth-promoting bacteria (PGPB) | BACTERIUM; BIOREMEDIATION; PERSPECTIVE; INSECTICIDE | Anticancer activities; Bacillus thuringiensis; Bioplastic; Food preservation; Nanoparticles biosynthesis; Plant growth-promoting bacteria (PGPB) | Agriculture; Anti-Infective Agents; Bacillus thuringiensis; Biodegradation, Environmental; Biological Control Agents; Biotechnology; Pest Control, Biological; antiinfective agent; butyric acid; heavy metal; nanoparticle; siderophore; antiinfective agent; antineoplastic activity; Bacillus thuringiensis; biofuel production; biological activity; bioremediation; biosynthesis; cancer inhibition; chemical structure; controlled study; drug development; drug toxicity; food preservation; nonhuman; phytopathogen; plant growth; plant growth-promoting bacterium; review; sustainable agriculture; synthesis; agriculture; biological control agent; biological pest control; biotechnology; metabolism; pharmacology; procedures | English | 2025 | 2025 (MAR-JUN) | 10.1016/j.resmic.2024.104264 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Identification of zoonotic pathogens in zoo animals in the Republic of Korea | Zoo animals may harbor various zoonotic pathogens and may pose a potential risk to humans through close contact. Nevertheless, epidemiological data on zoonotic diseases are scarce. Here, we conducted an epidemiological investigation and genetic characterization of Coxiella burnetii, Cryptosporidium species, Enterocytozoon bieneusi, and Giardia duodenalis in zoo animals in the Republic of Korea (ROK) and evaluated their zoonotic potential. A total of 261 fecal samples were collected from 27 animal species at one zoo between July 2022 and December 2023. Out of the four pathogens tested, one (0.4 %), twelve (4.5 %), and one (0.4 %) animals were found positive for C. burnetii, E. bieneusi, and G. duodenalis, respectively. Cryptosporidium species were not detected in zoo animals. Sequence analysis of C. burnetii based on the IS1111 gene revealed that one sequence obtained from a black goat (Capra hircus) exhibited 100 % homology with those reported from a rodent in the ROK. A zoonotic assemblage B (n = 1) of G. duodenalis was identified in Patagonian mara (Dolichotis patagonum). Of the 12 E. bieneusi-positive samples, eleven novel genotypes (KRZB1-4 and KRZS2-8) were identified in four Asian black bears (Ursus thibetanus ussuricus) and eight squirrel monkeys (Saimiri sciureus). Phylogenetically, ten novel genotypes belonged to group 1 with zoonotic potential, and one novel genotype, KRZB4, was assigned to group 10. This study showed that C. burnetii, E. bieneusi, and G. duodenalis infections were identified in zoo animals in the ROK. Our findings highlight the need for ongoing monitoring and effective strategies to prevent and control these zoonotic pathogens. | Um, Jinho; Kim, Jeongho; Cho, Seok-Jin; Park, Min-ho; Cho, Hyung-Chul; Park, Yu-Jin; Choi, Kyoung-Seong | Kyungpook Natl Univ, Coll Ecol & Environm Sci, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; CheongjuZoo, Cheongju 28542, South Korea; Kyungpook Natl Univ, Coll Ecol & Environm Sci, Dept Ecol Sci, Sangju 37224, South Korea | 59729819900; 57222670540; 59395536300; 57194724289; 57219427000; 57219426539; 7403949556 | kschoi3@knu.ac.kr; | INTERNATIONAL JOURNAL FOR PARASITOLOGY-PARASITES AND WILDLIFE | INT J PARASITOL-PAR | 2213-2244 | 27 | SCIE | ECOLOGY;PARASITOLOGY | 2024 | 2.2 | 43.6 | 0 | 2025-05-07 | 0 | 0 | Coxiella burnetii; Enterocytozoon bieneusi; Giardia duodenalis; Zoo animals; Zoonotic potential | ENTEROCYTOZOON-BIENEUSI; COXIELLA-BURNETII; GIARDIA-DUODENALIS; MOLECULAR CHARACTERIZATION; WATERBORNE TRANSMISSION; CRYPTOSPORIDIUM SPP.; WORLDWIDE OUTBREAKS; CAPTIVE WILDLIFE; PANTHERA-LEO; Q-FEVER | Coxiella burnetii; Enterocytozoon bieneusi; Giardia duodenalis; Zoo animals; Zoonotic potential | animal experiment; Article; blood analysis; bootstrapping; controlled study; Coxiella burnetii; Cryptosporidium; DNA extraction; Enterocytozoon bieneusi; epidemiological data; feces analysis; genotype; Giardia intestinalis; goat; infectious agent; lagomorph; nonhuman; Perissodactyla; phylogenetic tree; phylogeny; polymerase chain reaction; prevalence; rodent; Saimiri sciureus; sequence analysis; South Korea; zoo animal; zoonosis; zoonotic pathogen | English | 2025 | 2025-08 | 10.1016/j.ijppaw.2025.101067 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | A Preemptive Scan Speed Control Strategy Based on Topographic Data for Optimized Atomic Force Microscopy Imaging | Rapid advancement in the nanotechnology and semiconductor industries has driven the demand for fast, precise measurement systems. Atomic force microscopy (AFM) is a standout metrology technique due to its high precision and wide applicability. However, when operated at high speeds, the quality of AFM images often deteriorates, especially in areas where sharp topographic features are present. This occurs because the feedback speed of the Z-scanner cannot keep up with the sample height changes during raster scanning. This study presents a simple variable scan speed control strategy for improving AFM imaging speed while maintaining the image quality obtained at low scan speeds. The proposed strategy aims to leverage the similarity in the height profiles between successive scan lines. The topographic information collected from the previous line scan is used to assess the surface complexity and to adjust the scan speed for the following line scan. The AFM system with this variable speed control algorithm was found to reduce the scan time needed for one AFM image by over 50% compared to the fixed-speed scanning while maintaining the similar level of accuracy. The calculated mean square errors (MSEs) show that the combination of speed adjustments and preemptive surface topography prediction has successfully allowed us to suppress the potential oscillations during the speed adjustment process, thereby enhancing the stability of the adaptive AFM system as well. | Nguyen, Thi Thu; Juma, Oyoo Michael; Otieno, Luke Oduor; Nguyen, Thi Ngoc; Lee, Yong Joong | Kyungpook Natl Univ, Sch Mech Engn, 80 Daehakro, Bukgu 41566, Daegu, South Korea; Dedan Kimathi Univ Technol, Dept Elect & Elect Engn, Nyeri 10143, Kenya; Kyungpook Natl Univ, Dept Smart Mobil Engn, 80 Daehakro, Bukgu 41566, Daegu, South Korea | Otieno, Luke/KHW-8698-2024 | 58811314600; 58553964600; 57205578290; 57216184573; 57183248500 | thunt@knu.ac.kr; michaeljuma@knu.ac.kr; luke.otieno@dkut.ac.ke; 2022226280@knu.ac.kr; yjlee76@knu.ac.kr; | ACTUATORS | ACTUATORS | 2076-0825 | 14 | 6 | SCIE | ENGINEERING, MECHANICAL;INSTRUMENTS & INSTRUMENTATION | 2024 | 2.3 | 43.7 | 0 | 0 | atomic force microscopy (AFM); high-speed atomic force microscopy (HS-AFM); adaptive control; real-time control; fast scanning | DESIGN; AFM | adaptive control; atomic force microscopy (AFM); fast scanning; high-speed atomic force microscopy (HS-AFM); real-time control | English | 2025 | 2025-05-26 | 10.3390/act14060262 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Green Synthesis of Luminescent Silver Nanoparticles Using Annona reticulata Fruit: Evaluation of Biological and Environmental Applications | Green metal nanoparticles are used as building blocks for nanomedicine because they are safe, cheap, and last a long time. Natural products combined with silver nanoparticles (AgNPs) were identified by researchers to have applications in medicine and the environment. Our study focused on creating Annona reticulata fruit-based luminescent silver nanoparticles (ARF-AgNPs) and their antioxidant, antibacterial, and photocatalytic potential. The A. reticulata fruit-based luminescent silver nanoparticles (ARF-AgNPs) were characterized by UV-visible spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), and field emission scanning electron microscopy with energy dispersive X-ray spectroscopy (FESEM-EDX). The antioxidant action of ARF-AgNPs against DPPH radicals was found to show that at 500 mu g/mL, their activity level ranged from up to 80.21 +/- 0.91%. As bacterial pathogens, Staphylococcus aureus and Pseudomonas aeruginosa were used to assess the bactericidal efficacy of ARF-AgNPs. Furthermore, capable of accelerating the malachite green (MG) dye responses were the green ARF-AgNPs. Therefore, these findings suggest a feasible method for producing ARF-AgNPs from A. reticulata fruit rind, which can be used in several chemical and medicinal applications. | Chinnathambi, Thangam; Selvam, Kandasamy; Sudhakar, Chinnappan; Ragu Prasath, Arunagiri; Kamala-Kannan, Seralathan; Kim, Woong; Senbagam, Duraisamy | Mahendra Arts & Sci Coll Autonomous, Dept Biotechnol, Namakkal, Tamil Nadu, India; Saveetha Univ, Saveetha Dent Coll & Hosp, Dept Biomat, Chennai, India; Jeonbuk Natl Univ, Adv Inst Environm & Biosci, Coll Environm & Bioresource Sci, Div Biotechnol, Iksan, Jeonbuk, South Korea; Kyungpook Natl Univ, Dept Environm Engn, Daegu, South Korea; SRM Inst Sci & Technol, Fac Sci & Humanities, Dept Biotechnol, Kattankulathur, Tamil Nadu, India | Duraisamy, Senbagam/K-2475-2019; Sudhakar, Chinnappan/Y-8277-2019 | 59544623300; 57197362853; 56480308500; 58922748500; 55664148800; 55581636400; 58956978800 | ksk.selvam@gmail.com; | LUMINESCENCE | LUMINESCENCE | 1522-7235 | 1522-7243 | 40 | 6 | SCIE | CHEMISTRY, ANALYTICAL | 2024 | 3 | 43.7 | N/A | 0 | 0 | <fixed-case>Annona reticulata</fixed-case>; antibacterial action; antioxidant test; catalytic applications; silver nanoparticles | ANTIMICROBIAL ACTIVITY; ANTIOXIDANT; EXTRACT | Annona reticulata; antibacterial action; antioxidant test; catalytic applications; silver nanoparticles | Annona; Anti-Bacterial Agents; Antioxidants; Fruit; Green Chemistry Technology; Luminescence; Metal Nanoparticles; Microbial Sensitivity Tests; Pseudomonas aeruginosa; Silver; Staphylococcus aureus; Atomic emission spectroscopy; Green Synthesis; Medical nanotechnology; Near infrared spectroscopy; Pathogens; Silver nanoparticles; antiinfective agent; antioxidant; metal nanoparticle; silver; Annona reticulata; Antibacterial action; Antibacterials; Antioxidant test; Biological applications; Building blockes; Catalytic applications; Environmental applications; Green synthesis; Natural products; Annona; chemistry; drug effect; fruit; green chemistry; luminescence; microbial sensitivity test; Pseudomonas aeruginosa; Staphylococcus aureus; synthesis; Fourier transform infrared spectroscopy | English | 2025 | 2025-06 | 10.1002/bio.70230 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Investigating the Power Extraction of Applying Hybrid Pitching Motion on a Wing with Leading and Trailing Flaps | This research utilized a hybrid trajectory on a wing incorporating a dual flap with the goal of enhancing performance. The hybrid profiles initiate with a non-sinusoidal pattern during the interval 0.0 <= t/T <= 0.25, evolving toward a sinusoidal pattern within the range 0.25 < t/T <= 0.5. Similarly, the hybrid motion follows a non-sinusoidal pattern in the range 0.5 < t/T <= 0.75, before shifting back to a sinusoidal pattern within the range 0.75 < t/T <= 1.0. The effectiveness of using a hybrid trajectory on a wing with leading and trailing flaps in enhancing the energy harvesting performance is examined through numerical simulations. The results demonstrate that hybrid trajectories applied to a two-flap wing configuration outperform a single flat plate and a wing with leading and trailing flaps both operating under a sinusoidal trajectory. The wing length spans from 45% to 55%, with the leading flap length ranging from 25% to 35%. The trailing flap lengths adjust accordingly to ensure the combined total matches the flat plate's full length, which is 100%. The wing pitch angle was fixed at 85 degrees while the leading flap's pitch angle varied between 40 degrees and 55 degrees and the pitch angle of the trailing flap ranged from 0 degrees to 20 degrees. The findings reveal that utilizing hybrid motion on a wing fitted with leading and trailing flaps notably improves power output in comparison to configurations with either one plate or three plates. The power output is achieved at particular dimensions: a leading flap length of 30%, a wing length of 55%, and a trailing flap length of 15%. The corresponding pitch angles are 50 degrees for the leading flap, 85 degrees for the wing, and 10 degrees for the trailing flap. The aforementioned configuration results in a 34.06% increase in output power in comparison to one plate. The maximum efficiency for this setup reaches 44.21%. This underscores the superior performance of hybrid trajectories over sinusoidal trajectories in enhancing energy extraction performance. | Saleh, Suleiman; Sohn, Chang-Hyun | Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea | 59170922100; 36806852600 | suleiman@knu.ac.kr; chsohn@knu.ac.kr; | ACTUATORS | ACTUATORS | 2076-0825 | 14 | 2 | SCIE | ENGINEERING, MECHANICAL;INSTRUMENTS & INSTRUMENTATION | 2024 | 2.3 | 43.7 | 0 | 2025-05-07 | 1 | 1 | energy harvester; leading flaps; trailing flaps; hybrid motion; flapping flat plate | PERFORMANCE; AIRFOIL; FOIL | energy harvester; flapping flat plate; hybrid motion; leading flaps; trailing flaps | English | 2025 | 2025-02 | 10.3390/act14020062 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Effectiveness of an app-based walking program for obese patients with inflammatory bowel disease in Korea: a single-blind parallel-group randomized clinical trial | BackgroundObesity in patients with inflammatory bowel disease (IBD) not only exacerbates symptoms but also interferes with treatment and leads to additional complications. Therefore, managing weight loss and preventing obesity are crucial. This study was designed to develop and implement a 10-week walking exercise program, facilitated by a mobile application, to evaluate its effectiveness in managing weight in obese IBD patients.MethodsThis study was designed as a single-blind parallel-group randomized clinical trial. We enrolled 54 participants, randomly allocating 27 to the intervention group and 27 to the control group. The intervention group received educational materials, such as videos, and participants were instructed to walk a minimum of 7,000 steps on at least five days each week for a duration of 10 weeks. Additionally, they were required to submit weekly updates on weight-related information to the researchers. The primary outcomes measured were body mass index (BMI), body fat percentage, and skeletal muscle mass. Secondary outcomes included perceived stress, fatigue, and quality of life.ResultsA total of 49 participants were included in the data collection (intervention group: n = 24, control group: n = 25). Post-intervention, the intervention group demonstrated significant reductions in BMI (t = 3.57, p =.001) and body fat percentage (Z = 3.11, p =.002) compared to the control group. Furthermore, perceived stress (t = 2.20, p =.038) and fatigue (t = 2.10, p =.047) significantly decreased in the intervention group, but no significant differences were observed when compared to the control group.ConclusionsThe 10-week walking program utilizing a mobile app effectively reduced body fat among participants, indicating its potential to improve health management in clinical settings. Further research is necessary to explore changes in muscle mass and psychological variables.Trial registrationKorea Clinical Trials Registry number KCT0009461, 24/05/2024. | Lee, Young Jin; Kwon, Eun Ja; Park, Da-In; Park, Sang Hyoung; Hwang, Sung Wook; Ye, Byong Duk | Eulji Univ, Coll Nursing, 712 Dongil Ro, Uijongbu 11759, Gyeonggi Do, South Korea; Asan Med Ctr, Dept Nursing, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea; Asan Med Ctr, Inflammatory Bowel Dis Ctr, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea; Kyungpook Natl Univ, Res Inst Nursing Innovat, Coll Nursing, 80 Daehak Ro, Daegu 41566, South Korea; Univ Ulsan, Asan Med Ctr, Dept Gastroenterol, Coll Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea; Univ Ulsan, Inflammatory Bowel Dis Ctr, Asan Med Ctr, Coll Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea | Ye, Byong/AAF-4955-2020 | 57205689493; 57193314602; 56883531300; 59445080400; 59445552800; 59445321600 | youngjin@eulji.ac.kr; kej88000@hanmail.net; dain.park@knu.ac.kr; shpark78@amc.seoul.kr; snow903@gmail.com; bdyemd@gmail.com; | BMC GASTROENTEROLOGY | BMC GASTROENTEROL | 1471-230X | 25 | 1 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2024 | 2.6 | 43.9 | 0 | 2025-06-11 | 0 | 0 | App-based exercise; Walking; Inflammatory bowel disease; Body mass index; Body fat | QUALITY-OF-LIFE; PHYSICAL-ACTIVITY; EXERCISE; CROHNS; RISK; MANAGEMENT; COLITIS; IMPACT | App-based exercise; Body fat; Body mass index; Inflammatory bowel disease; Walking | Adult; Body Mass Index; Exercise Therapy; Female; Humans; Inflammatory Bowel Diseases; Male; Middle Aged; Mobile Applications; Obesity; Quality of Life; Republic of Korea; Single-Blind Method; Treatment Outcome; Walking; Weight Loss; adult; app based walking program; Article; body composition; body fat; body mass; body weight loss; breast cancer; controlled study; Crohn disease; depression; fatigue; female; follow up; human; inflammatory bowel disease; major clinical study; male; mental disease; musculoskeletal disease; obese patient; physical activity; quality of life; questionnaire; randomized controlled trial; remission; single blind procedure; total body fat; ulcerative colitis; walking; complication; kinesiotherapy; middle aged; mobile application; obesity; procedures; South Korea; therapy; treatment outcome | English | 2025 | 2025-05-30 | 10.1186/s12876-025-03962-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A Comparative Study on the Effects of Repeated Subacromial Injections of Parecoxib and Triamcinolone in a Rat Model of Normal Rotator Cuff | Background: This study aimed to investigate changes after repeated subacromial drug injections in a rat model of normal rotator cuff. Methods: Thirty-nine male Sprague-Dawley rats were divided into groups 1 (no injection, n = 3), 2 (parecoxib, n = 18; 6 subgroups, n = 3 each; 0.5 mg/kg), and 3 (triamcinolone, n = 18; 6 subgroups, n = 3 each; 0.3 mg/kg). Groups 2 and 3 received subacromial injections 1-6 times once weekly for 6 weeks. The supraspinatus and infraspinatus tendons and muscles were used for biomechanical and histological evaluation. The subacromial bursa was used to analyze the prostaglandin E2 (PEG2) level. Results: In the biomechanical test, load-to-failure and ultimate stress decreased in groups 2 and 3 with repeated injections and the values were significantly lower in group 3 than in group 1 only at the sixth injection (p = 0.007 and p = 0.008, respectively). On the Bonar score, the cellularity, ground substance, and total score were significantly different among the 3 groups at the fifth and sixth injections (cellularity: p = 0.028 and p = 0.033, ground substance: p = 0.018 and p = 0.006, and total score: p = 0.029 and p = 0.027, respectively). The myocyte cross-sectional area of the infraspinatus muscle showed a significant difference among the 3 groups at the third and fourth injections (p = 0.031 and p = 0.020, respectively). The PEG2 level in the subacromial bursa was significantly different among the 3 groups at the third, fifth, and sixth injections (p = 0.019, p = 0.004, and p = 0.004, respectively). Conclusions: In the rat model of normal rotator cuff, repeated local injections of the cyclooxygenase-2 inhibitor showed fewer negative effects on the biomechanical and histological properties of the normal tendon than triamcinolone. | Yoon, Jong Pil; Kim, Dong Hyun; Park, Sung-Jin; Choi, Yoon Seong; Lee, Hyun Joo; Chung, Seok Won; Lee, Kang-San; Lee, Jeoung Wook | Kyungpook Natl Univ, Sch Med, Dept Orthoped Surg, Daegu, South Korea; Kyungpook Natl Univ, Dept Carbon Hybrid Fiber Sci, Daegu, South Korea; Konkuk Univ, Sch Med, Med Ctr, Dept Orthoped Surg, Seoul, South Korea | 36098548400; 57198637188; 58527890700; 57013770300; 58838750100; 37065938600; 58967020700; 59721018700 | oskdh87090@gmail.com; | CLINICS IN ORTHOPEDIC SURGERY | CLIN ORTHOP SURG | 2005-291X | 2005-4408 | 17 | 2 | SCIE | ORTHOPEDICS | 2024 | 2 | 44.2 | 0 | 2025-05-07 | 0 | 0 | Rotator cuff; Cyclooxygenase 2 inhibitors; Triamcinolone; Injections | STEROID INJECTIONS; SKELETAL-MUSCLE; IMPINGEMENT SYNDROME; TENDON REPAIR; APOPTOSIS; CELECOXIB; EXERCISE; INHIBITION; TENOXICAM; BONE | Cyclooxygenase 2 inhibitors; Injections; Rotator cuff; Triamcinolone | Animals; Biomechanical Phenomena; Cyclooxygenase 2 Inhibitors; Isoxazoles; Male; Rats; Rats, Sprague-Dawley; Rotator Cuff; Triamcinolone; parecoxib; prostaglandin E2; triamcinolone; cyclooxygenase 2 inhibitor; isoxazole derivative; parecoxib; triamcinolone; animal experiment; animal model; Article; biomechanics; comparative effectiveness; controlled study; enzyme immunoassay; histology; infraspinatus muscle; infraspinatus tendon; male; nonhuman; rat; rat model; rotator cuff; Sprague Dawley rat; subacromial bursa; supraspinatus muscle; synovial bursa; tendon; animal; comparative study; drug effect; Sprague Dawley rat | English | 2025 | 2025-04 | 10.4055/cios23417 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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