연구성과로 돌아가기
2024 연구성과 (109 / 286)
※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ○ | ○ | Article | Thirty two port super wideband diversity antenna for indoor communications | This paper introduces a novel design featuring a thirty-two port diversity antenna with an elliptical shape, fed by an asymmetric coplanar waveguide (CPW). The antenna incorporates uneven meander lines, tailored for super-wideband (SWB) applications. The structure of the unit cell is of an elliptical patch with an elliptical slot, and it is connected to a rectangular stub and asymmetric meander line. The size of the single element is 22 mm x 20 mm, and it operates from 3 to 40 GHz. The bandwidth dimension ratio of the unit cell is 3911, bandwidth ratio is 13.33:1, and fractional bandwidth is 172.09%. The single element is developed into a 3-D thirty-two port diverse antenna, composed of a horizontal plane and four planes perpendicular to it. The diverse antenna has a peak gain of 12.5 dBi and an efficiency of 94%. The computed envelope correlation coefficient (ECC), as determined using S-parameters and far-field measurements, is less than 0.1. The attained diversity gains (DGs) of the developed MIMO antenna are above 9.9 dB in terms of both S-parameter and far-field computations. The obtained thirty-two port diverse antenna channel capacity loss (CCL) is below 0.25 bits/s/Hz. The mean effective gain (MEG) of the constructed thirty-two port antenna is below 2. To validate the appropriateness of the developed thirty-two port antenna for wireless indoor environment, an enclosure made of acrylonitrile butadiene styrene (ABS) is crafted and fabricated, and the characteristics of the proposed diverse antenna are investigated. | Joy, J. Annal; Palaniswamy, Sandeep Kumar; Kumar, Sachin; Kanagasabai, Malathi; Choi, Hyun Chul; Kim, Kang Wook | SRM Inst Sci & Technol, Fac Engn & Technol, Dept Elect & Commun Engn, Kattankulathur 603203, India; Galgotias Coll Engn & Technol, Dept Elect & Commun Engn, Greater Noida 201310, India; Anna Univ, Coll Engn, Dept Elect & Commun Engn, Chennai 600025, India; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | Kumar, Sachin/W-2211-2019; Kanagasabai, Malathi/ABH-5331-2020; Palaniswamy, Sandeep Kumar/AAF-2240-2021 | 59384765100; 56158830800; 56907994000; 55511179300; 57193342681; 57204432422 | vrpchs@gmail.com;kang_kim@ee.knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0.41 | 2025-05-07 | 1 | 2 | MIMO ANTENNA; DESIGN | 1,3 butadiene; acrylonitrile; styrene; article; bandwidth; clinical article; correlation coefficient; DNA transposon; indoor environment; therapy | English | 2024 | 2024-10-23 | 10.1038/s41598-024-76008-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Traumatic spinal cord injury in South Korea for 13 years (2008-2020) | Traumatic spinal cord injury (TSCI) has significant physical, psychological, and socioeconomic impacts. However, the epidemiological characteristics and treatment patterns of TSCI in South Korea remain unclear. This study aimed to investigate TSCI incidence and treatment behaviors in South Korea from 2008 to 2020. We included data from 30,979 newly diagnosed TSCI patients obtained from the Health Insurance Review and Assessment Service (HIRA). Treatment trends, location of surgery, surgical method, comorbidities, factors affecting hospital stay, and risk factors affecting readmission were analyzed. Patients were divided into the surgery group [n = 7719; (25%)] and the non-surgery group [n = 23,260; (75%)]. Surgical cases involved cervical (64%), thoracic (17%), and lumbar/sacral (19%) lesions. Anterior fusion (38%), posterior fusion (54%), and corpectomy (8%) were the surgical methods. Surgical treatments increased annually. Factors influencing hospital stay included male sex, older age, and higher Charlson comorbidity index (CCI). Female sex and higher CCI scores were associated with readmission. In conclusion, a quarter of all TSCI patients underwent surgery, with an upward trend. Risk factors for longer hospital stays were thoracic spine injury, older age, higher CCI, and male sex. Risk factors for readmission included age range of 40-59 years, lumbar/sacral spine injuries, CCI score of 2, and female sex. | Noh, Sung Hyun; Lee, Eunyoung; Kim, Kyoung-Tae; Kim, Sang Hyun; Cho, Pyung Goo | Ajou Univ, Ajou Univ Hosp, Dept Neurosurg, Sch Med, Suwon 164, South Korea; Yonsei Univ, Dept Neurosurg, Coll Med, Seoul, South Korea; UTHealth, Dept Neurol, McGovern Med Sch, Houston, TX USA; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Neurosurg, Daegu, South Korea | 57194978247; 57221419503; 57201369790; 57202337309; 56366637100 | ulove07@ajou.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0.41 | 2025-05-07 | 1 | 1 | EPIDEMIOLOGY | Adult; Back Injuries; Comorbidity; Female; Humans; Length of Stay; Male; Middle Aged; Retrospective Studies; Spinal Cord Injuries; Spinal Diseases; adult; comorbidity; complication; female; human; injury; length of stay; male; middle aged; retrospective study; spinal cord injury; spine disease | English | 2024 | 2024-04-09 | 10.1038/s41598-024-57965-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Ultra-thin flexible rectenna integrated with power management unit for wireless power harvester/charging of smartwatch/wristband | This paper proposes a circularly polarized ultra-thin flexible antenna with a flexible rectifier and power management unit (PMU) for smartwatch/wristband applications. The flexible antenna is compact (0.17 lambda 0 x 0.20 lambda 0 x 0.0004 lambda 0) and has a stepped ground plane. A parasitic element is used at the substrate bottom to reduce the specific absorption rate (SAR) and enhance the gain up to 3.2 dBi, at the resonating frequency of WLAN/Wi-Fi (2.45 GHz). The SAR of the proposed design is also analysed at the resonating frequency, and it satisfies the guidelines of the International Commission on Non-Ionizing Radiation Protection (ICNIRP) and IEEE C95.1-2019 human safety standards. An impedance matching circuit is used between the antenna and the RF energy harvester to improve conversion efficiency. Polarization mismatch is avoided with the help of circular polarization, achieved by tuning stubs of size 0.02 lambda 0 x 0.044 lambda 0. The integration of the antenna and rectenna results in a good conversion efficiency of 78.2% at - 5 dBm of input power with a load resistance of 2 K ohm. The availability of RF signals allows the user to charge the smartwatch/wristband by connecting the PMU circuit with the RF energy harvester. | Singh, Neeta; Khan, Taimoor; Kumar, Sachin; Kanaujia, Binod Kumar; Choi, Hyun Chul; Kim, Kang Wook; Rambabu, Karumudi; Rengarajan, Sembiam R.; Kishk, Ahmed A. | Guru Gobind Singh Indraprastha Univ, Univ Sch Automat & Robot, East Delhi Campus, Delhi, India; Natl Inst Technol Silchar, Dept Elect & Commun Engn, Silchar, India; Galgotias Coll Engn & Technol, Dept Elect & Commun Engn, Greater Noida, Uttar Pradesh, India; Dr BR Ambedkar Natl Inst Technol, Dept Elect & Commun, Jalandhar, India; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu, South Korea; Univ Alberta, Dept Elect & Comp Engn, Edmonton, AB, Canada; Calif State Univ Northridge, Dept Elect & Comp Engn, Northridge, CA 93063 USA; Concordia Univ, Dept Elect & Comp Engn, Montreal, PQ, Canada | Kanaujia, Binod/L-6484-2019; Khan, Taimoor/ACS-6543-2022; Kumar, Sachin/T-8715-2019 | 57202433135; 55189263800; 56907994000; 56962785800; 57193342681; 57204432422; 24171880600; 56219429900; 7004922524 | gupta.sachin0708@gmail.com;kang_kim@ee.knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 2.86 | 2025-05-07 | 6 | 9 | ANTENNA; COMPACT; RADIATION; PLATFORM; FILTER | absorption; article; DNA transposon; human; impedance; polarization; radiation protection | English | 2024 | 2024-03-28 | 10.1038/s41598-024-57639-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Validation of the 2022 European LeukemiaNet risk stratification for acute myeloid leukemia | This study aimed to validate the 2022 European LeukemiaNet (ELN) risk stratification for acute myeloid leukemia (AML). A total of 624 newly diagnosed AML patients from 1998 to 2014 were included in the analysis. Genetic profiling was conducted using targeted deep sequencing of 45 genes based on recurrent driver mutations. In total, 134 (21.5%) patients had their risk classification reassessed according to the 2022 ELN risk stratification. Among those initially classified as having a favorable risk in 2017 (n = 218), 31 and 3 patients were reclassified as having intermediate risk or adverse risk, respectively. Among the three subgroups, the 2022 ELN favorable-risk group showed significantly longer survival outcomes than the other groups. Within the 2017 ELN intermediate-risk group (n = 298), 21 and 46 patients were reclassified as having favorable risk or adverse risk, respectively, and each group showed significant stratifications in survival outcomes. Some patients initially classified as having adverse risk in 2017 were reclassified into the intermediate-risk group (33 of 108 patients), but no prognostic improvements were observed in this group. A multivariable analysis identified the 2022 ELN risk stratification, age, and receiving allogeneic hematopoietic cell transplantation as significant prognostic factors for survival. The 2022 ELN risk stratification enables more precise decisions for proceeding with allogeneic hematopoietic cell transplantation for AML patients. | Song, Ga-Young; Kim, Hyeon-Jong; Kim, Taehyung; Ahn, Seo-Yeon; Jung, Sung-Hoon; Kim, Mihee; Yang, Deok-Hwan; Lee, Je-Jung; Kim, Mi Yeon; Cheong, June-Won; Jung, Chul Won; Jang, Jun Ho; Kim, Hee- Je; Moon, Joon Ho; Sohn, Sang Kyun; Won, Jong-Ho; Park, Seong Kyu; Kim, Sung-Hyun; Choi, Chang Kyun; Kim, Hyeoung-Joon; Ahn, Jae-Sook; Kim, Dennis Dong Hwan | Chonnam Natl Univ, Chonnam Natl Univ Hwasun Hosp, Dept Hematol Oncol, Med Sch, Gwangju, Jeollanam Do, South Korea; Univ Toronto, Princess Margaret Canc Ctr, Dept Med Oncol & Hematol, Toronto, ON, Canada; Univ Toronto, Dept Comp Sci, Toronto, ON, Canada; Univ Toronto, Donnelly Ctr Cellular & Biomol Res, Toronto, ON, Canada; Chonnam Natl Univ, Hwasun Hosp, Genom Res Ctr Hematopoiet Dis, Gwangju, Jeollanam Do, South Korea; Yonsei Univ, Coll Med, Dept Internal Med, Div Hematol, Seoul, South Korea; Samsung Med Ctr, Div Hematol Oncol, Seoul, South Korea; Catholic Univ Korea, Dept Hematol, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Hematol Oncol, Daegu, South Korea; Soonchunhyang Univ, Coll Med, Dept Internal Med, Div Hematol & Oncol,Soonchunhyang Univ Hosp, Seoul, South Korea; Dong A Univ, Coll Med, Dept Hematol Oncol, Busan, South Korea; Natl Canc Ctr, Natl Canc Control Inst, Div Canc Registrat & Surveillance, Goyang, South Korea; Chonnam Natl Univ, Dept Internal Med, Hwasun Hosp, 322 Seoyang Ro, Hwasun Gun 58128, Jeollanam Do, South Korea | ; Won, Jongho/AAM-8322-2021; Lee, Sang-Jun/A-3892-2015; Park, Jung Hyun/HJA-3755-2022; Kim, Hee-Je/O-3501-2019; Kim, Dennis/AAH-8499-2019 | 57193027251; 7410128739; 55763792349; 55945078500; 55511978300; 57218694093; 8701758000; 7601478211; 57904806900; 7004933294; 56405934800; 56470133700; 7410130758; 56568642700; 13310226800; 26434081600; 57077159400; 56547959500; 58981029300; 7410127473; 22984055900; 58630764800 | f0115@chonnam.ac.kr;dr.dennis.kim@uhn.ca; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 2.86 | 2025-05-07 | 8 | 8 | Acute myeloid leukemia; Hematopoietic stem cell transplantation; Prognosis | PROGNOSTIC IMPACT; ALLELIC RATIO; MUTATIONS; TRANSPLANTATION; RECOMMENDATIONS; MANAGEMENT; DIAGNOSIS; SECONDARY; FLT3-ITD; OUTCOMES | Acute myeloid leukemia; Hematopoietic stem cell transplantation; Prognosis | Genetic Profile; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid, Acute; Risk Assessment; acute myeloid leukemia; genetic profile; genetics; hematopoietic stem cell transplantation; human; risk assessment | English | 2024 | 2024-04-12 | 10.1038/s41598-024-57295-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Wing geometric morphometrics and COI barcoding of Culex pipiens subgroup in the Republic of Korea | Two members of the Culex pipiens subgroup, Culex pallens and Culex pipiens f. molestus, are known to occur in the Republic of Korea (ROK). These species exhibit morphologically similar features and are challenging to distinguish below the species level. Therefore, this study utilized wing geometric morphometrics (GM) on the right wing of the Culex pipiens subgroup, alongside sequencing of the cytochrome c oxidase subunit I (COI) region. Mosquitoes were collected from 11 locations between June and October (2020-2022) to minimize regional and seasonal variations. Additionally, Culex pipiens f. pipiens, which is not native to the ROK, was included in the analysis. Culex tritaeniorhynchus, Aedes albopictus, and Anopheles sinensis, the primary vectors in the ROK, were used as outgroups for comparison. All three taxa in the Culex pipiens subgroup could be identified with an 82.4%-97.0% accuracy using GM. However, a comparison of the COI regions of the Culex pipiens subgroup revealed no clear differences between the taxa. These data can be used for accurate identification, contributing to effective mosquito control, in addition to providing a foundation for evolutionary and ecological studies on wing shape differences. | Jeon, Jiseung; Lee, Dong Yeol; Jo, Yewon; Ryu, Jihun; Kim, Eunjeong; Choi, Kwang Shik | Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat Biores Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Dok Do & Ulleung Do Isl, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Phylogen & Evolut, Daegu 41566, South Korea | ; Ryu, Jihun/MSY-6008-2025; Jeon, Jiseung/NRB-6964-2025 | 58673027200; 57377518800; 58798667000; 57210884178; 56892981600; 36602283400 | ksc@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0.82 | 2025-05-07 | 2 | 3 | DIPTERA-CULICIDAE; R PACKAGE; SEXUAL-DIMORPHISM; COMPLEX; MOSQUITO; VECTOR; SHAPE; IDENTIFICATION; TRANSMISSION; ENCEPHALITIS | Aedes albopictus; Animals; Culex pipiens; Culex tritaeniorhynchus; Mosquito Vectors; Republic of Korea; Aedes albopictus; animal; Culex pipiens; Culex tritaeniorhynchus; mosquito vector; South Korea | English | 2024 | 2024-01-09 | 10.1038/s41598-024-51159-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Case report: Management of recurrent pupillary optic capture with sutureless surgical technique using 7-0 polypropylene flange | Background To report a novel surgical technique for recurrent pupillary optic capture after flanged intraocular lens (IOL) fixation.Methods In this retrospective case series, we detail our use of two parallel 7-0 polypropylene sutures passed between the iris plane and the optic of scleral-fixated IOL to address pupillary optic capture. Flanges were created using ophthalmic cautery to secure it to the sclera without suture.Results Two eyes with pupillary optic capture underwent a sutureless surgical technique using 7-0 polypropylene flanges. No recurrences of pupillary optic capture were observed during the 1-year follow-up.Conclusion Our sutureless surgical technique using a 7-0 polypropylene flange was an effective, efficient, and less invasive approach for treating recurrent pupillary optic capture. | Kim, Dong Hyeon; Moon, Da Ru Chi; Kang, Yong Koo; Park, Dong Ho; Shin, Jae Pil; Kim, Dai Woo; Do, Jae Rock | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Ophthalmol, Daegu, South Korea; Nune Eye Hosp, Daegu, South Korea | KANG, YONG KOO/IVH-8723-2023 | 58922682300; 58923125000; 57204703736; 36676632900; 56517350400; 57095192800; 58600232100 | doojr@hanmail.net; | FRONTIERS IN MEDICINE | FRONT MED-LAUSANNE | 2296-858X | 11 | SCIE | MEDICINE, GENERAL & INTERNAL | 2024 | 3 | 18.2 | 0 | 2025-04-16 | 0 | 0 | flanged intraocular lens fixation; intraocular lens dislocation; pupillary optic capture; sutureless | PIGMENT DISPERSION SYNDROME; CHAMBER INTRAOCULAR-LENS; PARS-PLANA VITRECTOMY; SCLERAL FIXATION; DISLOCATION; SAFETY; RISK | 7–0 polypropylene flange; flanged intraocular lens fixation; intraocular lens dislocation; pupillary optic capture; sutureless | levofloxacin; pilocarpine; silicone oil; adult; anterior eye segment; Article; best corrected visual acuity; blunt trauma; blurred vision; case report; case study; cauterization; clinical article; eye pain; follow up; human; implant complication; intraocular pressure; iridectomy; iris; lens implantation; lens luxation; lens subluxation; male; middle aged; operation duration; optical coherence tomography; pars plana vitrectomy; phacoemulsification; photopsia; pupil disease; pupillary optic capture; recurrent disease; retina detachment; retrospective study; sclera; slit lamp microscopy; sutureless technique; vitreous hemorrhage | English | 2024 | 2024-02-22 | 10.3389/fmed.2024.1367905 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Comparative Effects of Calcium, Boron, and Zinc Inhibiting Physiological Disorders, Improving Yield and Quality of Solanum lycopersicum | Simple Summary The tomato is the 2nd major vegetable crop consumed after the potato. It is constantly grown throughout the world, and there is an increasing global demand for it in food industries. Moreover, tomatoes are nutritious vegetables and help to reduce the attack of cancer and cardiovascular diseases. In addition, it remains an economic crop and an important source of income for farmers. Hence, there is a need to meet all the requirements of plant cultivation to obtain greater productivity with good-quality fruits, such as preventing physiological diseases, i.e., blossom end rot and fruit cracking disorders, which reduce marketable tomato yield. More attention should be paid to the factors affecting production to ensure the highest productivity and highest quality. Improving plant nutrition such as calcium, boron, and zinc is one reliable strategy to increase productivity and quality.Abstract Localized calcium deficiency at the tomato flower end causes a physiological disorder called blossom end rot, resulting in yield losses of up to 50 percent. Fruit cracking is another physiological disorder of tomatoes that most often occurs when the movement of water and solutes to the tomato is protracted or rapid, but the underlying cause of fruit cracking is, again, calcium deficiency. Therefore, the present field experiment was conducted with the aim of increasing yield and reducing physiological disorders in tomatoes with a foliar application of calcium and micronutrients (zinc and boron). Four levels of calcium (0, 0.3, 0.6, and 0.9%), three levels of boron (0, 0.25, and 0.5%), and three levels of Zinc (0, 0.25, and 0.5%) were applied foliarly three times (starting at flowering, the 2nd application was repeated when the fruits set, and the 3rd after a period of 15 days from the fruits set). An addition of 0.6% calcium increased yield and associated traits with a decreased flower drop. Likewise, a 0.9% calcium addition increased fruit Ca content and decreased blossom end rot, fruit cracking, and Zn content. Foliar spraying with 0.25% boron (compound B) improved flowering and production while reducing flower drop and tomato fruit cracking. Similarly, an application of 0.5% B significantly increased Ca and B content with minimal blossom end rot and Zn content. Likewise, a 0.5% Zn application resulted in yield and yield-related traits with increased fruit B and Zn contents while blossom end rot, fruit cracking, and fruit Ca content were lower when 0.5% of foliar Zn was applied. Therefore, it is concluded that a foliar application of Ca, B, and Zn can be used alone or in combination to minimize the physiological disorders, increase production, and improve tomato fruit quality. | Haleema, Bibi; Shah, Syed Tanveer; Basit, Abdul; Hikal, Wafaa M.; Arif, Muhammad; Khan, Waleed; Said-Al Ahl, Hussein A. H.; Fhatuwani, Mudau | Agr Res Inst ARI, Floriculture Sect, Tarnab 25120, Pakistan; Hazara Univ, Dept Agr, Mansehra 21300, Pakistan; Kyungpook Natl Univ, Dept Hort Sci, Floricultural Biotechnol Lab, Daegu 41566, South Korea; Univ Tabuk, Fac Sci, Dept Biol, Tabuk 71491, Saudi Arabia; Univ Agr, Dept Agron, Peshawar 25120, Pakistan; Kyungpook Natl Univ, Dept Appl Biosci, Lab Crop Prod, Daegu 41566, South Korea; Natl Res Ctr NRC, Pharmaceut & Drug Ind Res Inst, Med & Aromat Plants Res Dept, 33 El Behouth St, Giza 12622, Egypt; Univ KwaZulu Natal, Sch Agr Earth & Environm Sci, Private Bag X01, ZA-3209 Pietermaritzburg, South Africa | Basit, Abdul/AAX-2414-2021; Hikal, Wafaa/N-3939-2018; Ahl, Hussein/F-6815-2018; ARIF, MUHAMMAD/B-3098-2018; Mudau, Fhatuwani/M-7788-2014 | 54400986700; 56089730700; 58696991300; 55766415500; 57619606700; 57822855200; 32868150500; 57190605476 | haleema_12@yahoo.co.in;dr.syedtanveershah@hu.edu.pk;abdulbasit97_lily@knu.ac.kr;wafaahikal@gmail.com;marifkhan75@aup.edu.pk;waleedkhan.my@gmail.com;shussein272@yahoo.com;mudauf@ukzn.ac.za; | BIOLOGY-BASEL | BIOLOGY-BASEL | 2079-7737 | 13 | 10 | SCIE | BIOLOGY | 2024 | 3.5 | 18.2 | 0 | 2025-05-07 | 2 | 4 | deficiency; physiological disorders; micronutrients; tomato; correlation | FRUIT CRACKING; PLANT-GROWTH; FOLIAR APPLICATION; TOMATO; RHIZOBACTERIA; COMBINATION; REDUCTION; STRESS | correlation; deficiency; micronutrients; physiological disorders; tomato | English | 2024 | 2024-10 | 10.3390/biology13100766 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effect of the oral examinations in the national health screening program on preventive oral health care and treatments: a 19-year follow-up study | Objectives The national health screening (NHS) program in Korea serves as primary prevention by detecting oral diseases early for easier management. Dental scaling helps prevent oral disease and treat early periodontal disease. This study evaluated the effects of national oral examinations (NOE) in NHS on preventive oral hygiene care and dental treatments for a 19-year follow-up study. Methods We conducted a longitudinal observation of Korean adults >= 19 years between 2002 and 2003 from the Korean National Health Insurance Service (n = 4,669,107; men = 2,518,704; women = 2,150,403). The independent variable involved tracking the number of people who underwent the NOE recruited between 2002 and 2003 from 2002 to 2013. The dependent variables pertained to the number of dental scaling and the presence or absence of periodontal and dental caries treatments from 2014 to 2020. Results Individuals receiving 6 to 7 dental scaling during the follow-up exhibited an adjusted odds ratio (AOR) of 2.91 in the NOE-middle (3-4 times) and 3.30 in the NOE-high (5-6 times) (p < 0.001). The adjusted rate ratios were 1.69 in the NOE-middle and 1.77 in the NOE-high (p < 0.001). The AOR for periodontal treatment was 1.23 in the NOE-middle and NOE-high (p < 0.001). Conclusion Frequent NOEs lead to undergoing dental scaling and dental treatment, highlighting the importance of encouraging NOE attendance to improve population oral health. Expanding the scope of dental coverage for preventive intervention combined with NOE could help encourage greater participation and promote preventive oral healthcare. | Go, Hyeonjeong; Kuboniwa, Masae; Choi, Youn-Hee | Kyungpook Natl Univ, Sch Dent, Dept Prevent Dent, 2177 Dalgubeol Daero, Daegu, South Korea; Osaka Univ, Dept Prevent Dent, Grad Sch Dent, 1-8 Yamadaoka, Suita, Osaka, Japan; Kyungpook Natl Univ, Inst Translat Res Dent, 2177 Dalgubeol Daero, Daegu, South Korea | 57196085646; 56089471500; 7404777239 | cyh1001@knu.ac.kr; | BMC ORAL HEALTH | BMC ORAL HEALTH | 1472-6831 | 24 | 1 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2024 | 3.1 | 18.2 | 0 | 2025-05-07 | 0 | 0 | Korean National Health Service Insurance; Cohort database; National Health Screening; Oral examination; Dental scaling; Dental treatment | COST; LIFE | Cohort database; Dental scaling; Dental treatment; Korean National Health Service Insurance; National Health Screening; Oral examination | Adult; Aged; Dental Caries; Dental Scaling; Female; Follow-Up Studies; Humans; Longitudinal Studies; Male; Mass Screening; Middle Aged; National Health Programs; Oral Health; Republic of Korea; Young Adult; adult; aged; dental caries; dental scaling; diagnosis; female; follow up; health; human; longitudinal study; male; mass screening; middle aged; prevention and control; procedures; public health; South Korea; young adult | English | 2024 | 2024-11-28 | 10.1186/s12903-024-05239-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Exploring the relationship between ultrasound parameters and muscle strength in older adults: a meta-analysis of sarcopenia-related exercise performance | Introduction: Ultrasound (US) imaging has emerged as a promising tool for assessing age-related muscle changes. This meta-analysis aimed to comprehensively evaluate the associations between US parameters and muscle strength, as well as sarcopenia-related functional performance in older adults by integrating data from multiple studies. Methods: A systematic literature search was conducted in PubMed, Web of Science, and Embase until June 2023. Studies reporting Pearson's correlation coefficients between US parameters [echo intensity (EI), muscle thickness (MT), cross-sectional area (CSA), pinnations angle (PA), fascicle length (FL)] and measures of muscle strength or physical performance in older adults were included. Effect sizes were pooled using a random-effects model and presented in forest plots. Heterogeneity was assessed using I-2, and publication bias was evaluated using Egger's test. Results: Twenty-eight studies met the inclusion criteria. Meta-analysis revealed moderate to strong correlations between EI, MT, and CSA with muscle strength. However, no significant associations were found between US parameters and gait speed. For chair stand tests, the strength of associations varied by test type, with weak correlations observed between echo intensity and muscle thickness with sit-to-stand tests. US parameters did not exhibit significant correlations with the Timed Up and Go test. Conclusion: Ultrasonographic measurements of echo intensity (EI) and muscle thickness (MT) demonstrated moderate to strong correlations with muscle strength and functional assessments related to sarcopenia. To enhance the accuracy of sarcopenia diagnosis and the effectiveness of management strategies, there is a need for larger, longitudinal studies that evaluate a comprehensive range of ultrasonographic parameters. | Yuan, Han; Kim, Maeng-Kyu | Kyungpook Natl Univ, Grad Sch, Dept Phys Educ, Daegu, South Korea; Kyungpook Natl Univ, Sports Sci Res Inst, Daegu, South Korea | 58784951600; 26021932400 | kimmk@knu.ac.kr; | FRONTIERS IN MEDICINE | FRONT MED-LAUSANNE | 2296-858X | 11 | SCIE | MEDICINE, GENERAL & INTERNAL | 2024 | 3 | 18.2 | 0 | 2025-05-07 | 1 | 2 | ultrasonography; sarcopenia; muscle strength; physical functional performance; older adult | ECHO INTENSITY; SKELETAL-MUSCLE; THICKNESS; POWER; GAIT; ARCHITECTURE; ASSOCIATION; RELIABILITY; PENNATION; DIAGNOSIS | muscle strength; older adult; physical functional performance; sarcopenia; ultrasonography | bioelectrical impedance analysis; connective tissue; echography; elasticity; exercise; functional near-infrared spectroscopy; grip strength; human; meta analysis; muscle function; muscle strength; muscle thickness; physical performance; publication bias; quality of life; Review; sarcopenia; sit-to-stand test; timed up and go test; walking speed | English | 2024 | 2024-09-27 | 10.3389/fmed.2024.1429530 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Long-term prognostic value of the GenesWell BCT score in Asian women with hormone receptor-positive/HER2-negative early breast cancer | Background Accurate prediction of the risk of recurrence is crucial for optimal treatment decisions in hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative early breast cancer. The GenesWell BCT is a molecular assay to predict the 10-year risk of distant metastasis. In this study, we evaluated the long-term prognostic value of the GenesWell BCT assay.Methods The BCT score was assessed in patients with HR-positive/HER2-negative early breast cancer who did not receive chemotherapy. We compared the 15-year distant metastasis-free survival (DMFS) between risk groups classified based on the BCT score. The risk of early (0-5 years) and late (5-15 years) recurrence was evaluated based on the BCT score classification.Results According to the BCT score, 366 patients from Japan and Korea were categorized as BCT low risk (83.6%) and high risk (16.4%) for distant metastasis. Median follow-up time was 17.4 years. The 15-year DMFS rate was significantly lower in the BCT high-risk group (63.3%) than in the BCT low-risk group (93.6%) (P 50 years, and added prognostic information to traditional clinical prognostic factors.Conclusion The BCT score can identify patients at low risk for recurrence who may not require adjuvant chemotherapy or extended endocrine therapy, regardless of age. | Fujiki, Yoshitaka; Kashiwaba, Masahiro; Sato, Mutsumi; Kawano, Junko; Teraoka, Megumi; Kanemitsu, Shuichi; Rai, Yoshiaki; Taira, Tetsuhiko; Sagara, Yoshiaki; Ohi, Yasuyo; Jo, Uiree; Lee, Young-Won; Lee, Sae Byul; Gong, Gyungyub; Shin, Young Kee; Kwon, Mi Jeong; Sagara, Yasuaki | Hakuaikai Social Med Corp, Sagara Hosp, Dept Breast & Endocrine Surg Oncol, 3-28 Matsubara, Kagoshima 8920098, Japan; Hakuaikai Social Med Corp, Sagara Hosp, Dept Med Oncol, Kagoshima, Japan; Hakuaikai Social Med Corp, Dept Radiol, Sagara Hosp, Kagoshima, Japan; Hakuaikai Social Med Corp, Sagara Hosp, Dept Pathol, Kagoshima, Japan; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol, Seoul, South Korea; Univ Ulsan, Coll Med, Dept Surg, Div Breast Surg,Asan Med Ctr, Seoul, South Korea; Seoul Natl Univ, Res Inst Pharmaceut Sci, Lab Mol Pathol & Canc Genom, Seoul, South Korea; Seoul Natl Univ, Coll Pharm, Seoul, South Korea; Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Dept Mol Med & Biopharmaceut Sci, Seoul, South Korea; Kyungpook Natl Univ, Coll Pharm, Vessel Organ Interact Res Ctr, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Pharm, BK21 FOUR Community Based Intelligent Novel Drug D, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu, South Korea | ; Sagara, Yasuaki/AAE-3747-2020; Lee, Youngwon/KEH-3755-2024 | 55353189000; 6701833562; 57483262600; 57190161734; 53364553700; 57190178104; 8947444400; 55796692000; 8947443900; 7102248837; 57221192206; 57212766550; 56556623100; 7103214892; 26428533000; 35278164800; 14825706100 | mjkwon94@knu.ac.kr;yas794@mail.harvard.edu; | BREAST CANCER | BREAST CANCER-TOKYO | 1340-6868 | 1880-4233 | 31 | 1 | SCIE | OBSTETRICS & GYNECOLOGY;ONCOLOGY | 2024 | 2.9 | 18.2 | 0 | 2025-04-16 | 1 | 1 | GenesWell BCT score; Hormone receptor-positive/HER2-negative breast cancer; Prognostic value; Late recurrence; Asian women | LATE DISTANT RECURRENCE; ENDOCRINE THERAPY; PAM50 RISK; COMBINATION; PREDICTION; TAMOXIFEN; PROFILE; ASSAY | Asian women; GenesWell BCT score; Hormone receptor-positive/HER2-negative breast cancer; Late recurrence; Prognostic value | Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Humans; Neoplasm Recurrence, Local; Prognosis; Receptor, ErbB-2; Risk Factors; antineoplastic agent; epidermal growth factor receptor 2; adult; age; aged; Article; Asian; cancer classification; cancer genetics; cancer grading; cancer patient; cancer prognosis; cancer recurrence; cohort analysis; confidence interval; controlled study; distant metastasis; distant metastasis free survival; female; follow up; GenesWell Breast Cancer Test; hazard ratio; high risk patient; histology; hormone receptor-positive, HER2-negative breast cancer; human; Japan; Korea; low risk patient; major clinical study; molecular diagnosis; retrospective study; tumor volume; adjuvant chemotherapy; breast tumor; genetics; metabolism; prognosis; risk factor; tumor recurrence | English | 2024 | 2024-01 | 10.1007/s12282-023-01509-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | NKG2D (Natural Killer Group 2, Member D) ligand expression and ameloblastoma recurrence: a retrospective immunohistological pilot study | Background/PurposeThis retrospective immunohistological pilot study aimed to investigate the influence of natural killer group 2, member D (NKG2D) ligand expression on ameloblastoma recurrence after surgical resection. It also aimed to elucidate additional clinical factors that could serve as predictors of ameloblastoma recurrence.Materials and methodsThis study included 96 patients who were histologically diagnosed with ameloblastoma after surgical resection. The expression of NKG2D ligands, including UL16-binding proteins (ULBPs) 1-3 and major histocompatibility complex class I chain-related molecule (MIC) A/B, was evaluated in formalin-fixed paraffin-embedded tumor tissues via immunohistochemistry assays. Furthermore, the patients' electronic medical records were reviewed. Multivariate Cox regression analysis was conducted, and data were expressed as adjusted hazard ratios [HRs] with 95% confidence intervals [95% CIs].ResultsMultivariate analysis revealed that recurrent tumors (ref.: primary; adjusted HR [95% CI]: 2.780 [1.136, 6.803], p = 0.025) and positive MICA/B expression (ref.: negative; adjusted HR [95% CI]: 0.223 [0.050, 0.989], p = 0.048) independently affected recurrence-free survival in ameloblastoma.ConclusionThis study identified recurrent cases and loss of MICA/B expression as independent predictors of early ameloblastoma recurrence following surgical resection. The findings suggest that decreased MICA/B expression might undermine NKG2D-mediated tumor immunosurveillance, thereby influencing early recurrence. | Kim, Mee-seon; Jeon, Soeun; Lee, Hyeon Jeong; Ri, Hyun-Su; Cho, Ah-Reum; Park, Eun Ji; Yeo, Jin Song; Kim, Jae-Han; Lee, Jiyoun | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Dent, Dept Pathol, Daegu, South Korea; Kyungpook Natl Univ, Inst Translat Res Dent, Sch Dent, Dept Anesthesia & Pain Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Chilgok Hosp, Sch Med, Dept Anesthesia & Pain Med, Daegu, South Korea; Pusan Natl Univ, Sch Med, Dept Anesthesia & Pain Med, Busan, South Korea; Pusan Natl Univ Hosp, Biomed Res Inst, Busan, South Korea; Kyungpook Natl Univ, Sch Med, Dept Anesthesia & Pain Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Daegu, South Korea; Seoul Natl Univ Bundang Hosp, Dept Anesthesiol & Pain Med, Seongnam, South Korea | 59510682600; 57190426433; 38061496500; 42462457900; 37030745800; 57218404061; 58559264400; 58819790400; 57208715584 | jseanes@knu.ac.kr; | BMC ORAL HEALTH | BMC ORAL HEALTH | 1472-6831 | 24 | 1 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2024 | 3.1 | 18.2 | 0 | 2025-05-07 | 0 | 0 | Ameloblastoma; Odontogenic tumors; Killer cells, natural; Cytotoxicity, immunologic | FOLLOW-UP; JAWS | Ameloblastoma; Cytotoxicity, immunologic; Killer cells, natural; Odontogenic tumors | Adolescent; Adult; Aged; Ameloblastoma; Female; Humans; Immunohistochemistry; Jaw Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; NK Cell Lectin-Like Receptor Subfamily K; Pilot Projects; Retrospective Studies; Young Adult; KLRK1 protein, human; natural killer cell lectin like receptor subfamily K; adolescent; adult; aged; ameloblastoma; female; human; immunohistochemistry; jaw tumor; male; metabolism; middle aged; pathology; pilot study; retrospective study; surgery; tumor recurrence; young adult | English | 2024 | 2024-09-17 | 10.1186/s12903-024-04873-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Regulatory Dynamics of Plant Hormones and Transcription Factors under Salt Stress | Simple Summary The current review article focused on the complex interaction between plant hormones and transcription factors in the response to salt stress, a pressing global issue that has a considerable effect on agricultural productivity. The study unveils the effect of salt stress on the ion equilibrium and triggers a cascade of molecular reactions that have a response to plant growth and development. Transcription factors are essential in regulating gene expression under salt stress. The transcription factors function in collaboration with hormones to regulate environmental stress responses. The study sheds light on the underlying regulatory networks, thus providing crucial knowledge for cultivating salt-tolerant crops through selective breeding and genetic engineering. This review significantly contributes to the establishment of sustainable agricultural techniques, which are essential in addressing the increasing problem of soil salinization and securing global food security.Abstract The negative impacts of soil salinization on ion homeostasis provide a significant global barrier to agricultural production and development. Plant physiology and biochemistry are severely affected by primary and secondary NaCl stress impacts, which damage cellular integrity, impair water uptake, and trigger physiological drought. Determining how transcriptional factors (TFs) and hormone networks are regulated in plants in response to salt stress is necessary for developing crops that tolerate salt. This study investigates the complex mechanisms of several significant TF families that influence plant responses to salt stress, involving AP2/ERF, bZIP, NAC, MYB, and WRKY. It demonstrates how these transcription factors (TFs) help plants respond to the detrimental effects of salinity by modulating gene expression through mechanisms including hormone signaling, osmotic stress pathway activation, and ion homeostasis. Additionally, it explores the hormonal imbalances triggered by salt stress, which entail complex interactions among phytohormones like jasmonic acid (JA), salicylic acid (SA), and abscisic acid (ABA) within the hormonal regulatory networks. This review highlights the regulatory role of key transcription factors in salt-stress response, and their interaction with plant hormones is crucial for developing genome-edited crops that can enhance agricultural sustainability and address global food security challenges. | Aizaz, Muhammad; Jan, Rahmatullah; Asaf, Sajjad; Bilal, Saqib; Kim, Kyung-Min; AL-Harrasi, Ahmed | Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa 616, Oman; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea | ; Jan, Rahmatullah/AIC-3439-2022; Kim, Kyung-Min Kim/C-7007-2014; Asaf, Sajjad/ABA-3647-2021; Ul-Hamid, Anwar/B-7297-2015 | 57224641342; 57200621537; 57201981969; 56595059900; 57031617400; 34868260300; 6506093146 | rehmatbot@yahoo.com;sajadasif2000@gmail.com;kkm@knu.ac.kr;aharrasi@unizwa.edu.om; | BIOLOGY-BASEL | BIOLOGY-BASEL | 2079-7737 | 13 | 9 | SCIE | BIOLOGY | 2024 | 3.5 | 18.2 | 2.44 | 2025-05-07 | 12 | 12 | salinity; plant response; hormones; ABA; JA; signaling | RESPONSIVE GENE-EXPRESSION; ABSCISIC-ACID; ABIOTIC STRESS; FUNCTIONAL-ANALYSIS; SIGNAL-TRANSDUCTION; DROUGHT TOLERANCE; SALINITY STRESS; LOW-TEMPERATURE; ARABIDOPSIS-THALIANA; DISEASE RESISTANCE | ABA; hormones; JA; plant response; salinity; signaling | English | 2024 | 2024-09 | 10.3390/biology13090673 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | The clinical course of hospitalized COVID-19 patients and aggravation risk prediction models: a retrospective, multi-center Korean cohort study | BackgroundUnderstanding the clinical course and pivotal time points of COVID-19 aggravation is critical for enhancing patient monitoring. This retrospective, multi-center cohort study aims to identify these significant time points and associate them with potential risk factors, leveraging data from a sizable cohort with mild-to-moderate symptoms upon admission.MethodsThis study included data from 1,696 COVID-19 patients with mild-to-moderate clinical severity upon admission across multiple hospitals in Daegu-Kyungpook Province (Daegu dataset) between February 18 and early March 2020 and 321 COVID-19 patients at Seoul Boramae Hospital (Boramae dataset) collected from February to July 2020. The approach involved: (1) identifying the optimal time point for aggravation using survival analyses with maximally selected rank statistics; (2) investigating the relationship between comorbidities and time to aggravation; and (3) developing prediction models through machine learning techniques. The models were validated internally among patients from the Daegu dataset and externally among patients from the Boramae dataset.ResultsThe Daegu dataset showed a mean age of 51.0 +/- 19.6 years, with 8 days for aggravation and day 5 being identified as the pivotal point for survival. Contrary to previous findings, specific comorbidities had no notable impact on aggravation patterns. Prediction models utilizing factors including age and chest X-ray infiltration demonstrated promising performance, with the top model achieving an AUC of 0.827 in external validation for 5 days aggravation prediction.ConclusionOur study highlights the crucial significance of the initial 5 days period post-admission in managing COVID-19 patients. The identification of this pivotal time frame, combined with our robust predictive models, provides valuable insights for early intervention strategies. This research underscores the potential of proactive monitoring and timely interventions in enhancing patient outcomes, particularly for those at risk of rapid aggravation. Our findings offer a meaningful contribution to understanding the COVID-19 clinical course and supporting healthcare providers in optimizing patient care and resource allocation. | Moon, Min Kyong; Ham, Hyeonjung; Song, Soo Min; Lee, Chanhee; Goo, Taewan; Oh, Bumjo; Lee, Seungyeoun; Kim, Shin-Woo; Park, Taesung | Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; SMG SNU Boramae Med Ctr, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Interdisciplinary Program Bioinformat, Seoul, South Korea; Seoul Natl Univ, Dept Family Med, Coll Med, Seoul, South Korea; SMG SNU Boramae Med Ctr, Dept Family Med, Seoul, South Korea; Sejong Univ, Dept Math & Stat, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Seoul Natl Univ, Dept Stat, Seoul, South Korea | Goo, Taewan/HZJ-5608-2023; Moon, Min/J-5466-2012; Oh, Bumjo/GWN-2776-2022 | ksw2kms@knu.ac.kr;tspark@stats.snu.ac.kr; | FRONTIERS IN MEDICINE | FRONT MED-LAUSANNE | 2296-858X | 10 | SCIE | MEDICINE, GENERAL & INTERNAL | 2024 | 3 | 18.2 | 1 | COVID-19; disease progression; case fatality rate; statistical model; clinical decision support | INHALED CORTICOSTEROIDS; DISEASE; OUTCOMES | English | 2024 | 2024-01-04 | 10.3389/fmed.2023.1239789 | 바로가기 | 바로가기 | 바로가기 | |||||||||||
| ○ | ○ | Article | Trastuzumab deruxtecan versus treatment of physician's choice in previously treated Asian patients with HER2-low unresectable/metastatic breast cancer: subgroup analysis of the DESTINY-Breast04 study | Background In the global phase 3 DESTINY-Breast04 study (NCT03734029), the anti-human epidermal growth factor 2 (HER2) antibody-drug conjugate trastuzumab deruxtecan (T-DXd) demonstrated a statistically significant improvement in progression-free survival (PFS) and overall survival (OS), with manageable safety compared with treatment of physician's choice (TPC) in patients with HER2-low metastatic breast cancer (mBC) who had received 1-2 prior lines of chemotherapy. Methods This subgroup analysis examined the efficacy and safety of T-DXd versus TPC in 213 patients from Asian countries and regions who were enrolled in the DESTINY-Breast04 trial and randomized to T-DXd (n = 147) or TPC (n = 66). Results Median PFS with T-DXd and TPC was 10.9 and 5.3 months, respectively, in Asian patients with hormone receptor-positive mBC, and 10.9 and 4.6 months, respectively, in the overall Asian population. In both populations, median OS was not reached with T-DXd and was 19.9 months with TPC. The objective response rate was higher with T-DXd versus TPC in all Asian patients. Median treatment duration was 8.4 months with T-DXd and 3.5 months with TPC. The most common grade >= 3 drug-related treatment-emergent adverse events in Asian patients treated with T-DXd were neutropenia (16.3%), anemia (12.9%), and leukopenia (11.6%); the incidences of neutropenia and leukopenia were higher with TPC versus T-DXd. Adjudicated drug-related interstitial lung disease or pneumonitis with T-DXd was 14.3%; the majority of events were grade 1-2. Conclusions T-DXd demonstrated clinically meaningful survival benefits versus TPC in Asian HER2-low mBC patients, regardless of hormone receptor status, with no new safety signals. | Yamashita, Toshinari; Sohn, Joo Hyuk; Tokunaga, Eriko; Niikura, Naoki; Park, Yeon Hee; Lee, Keun Seok; Chae, Yee Soo; Xu, Binghe; Wang, Xiaojia; Im, Seock-Ah; Li, Wei; Lu, Yen-Shen; Aguilar, Cecilia Orbegoso; Nishijima, Soichiro; Nishiyama, Yuji; Sugihara, Masahiro; Modi, Shanu; Tsurutani, Junji | Kanagawa Canc Ctr, Yokohama, Kanagawa, Japan; Yonsei Univ Hlth Syst, Seoul, South Korea; NHO Kyushu Canc Ctr, Fukuoka, Japan; Tokai Univ, Sch Med Hosp, Hiratsuka, Kanagawa, Japan; Samsung Med Ctr, Seoul, South Korea; Natl Canc Ctr, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Daegu, South Korea; Chinese Acad Med Sci, Peking Union Med Coll, Canc Hosp, Beijing, Peoples R China; Zhejiang Canc Hosp, Hangzhou, Peoples R China; Seoul Natl Univ, Seoul Natl Univ Hosp, Canc Res Inst, Coll Med, Seoul, South Korea; First Hosp Jilin Univ, Jilin, Peoples R China; Natl Taiwan Univ Hosp, Taipei, Taiwan; Daiichi Sankyo France SAS, Rueil Malmaison, France; Daiichi Sankyo Co Ltd, Tokyo, Japan; Mem Sloan Kettering Canc Ctr, New York, NY USA; Showa Univ Hosp, Innovat Ctr Translat Res & Clin Sci Canc Therapy, Tokyo, Japan; Showa Univ, Adv Canc Translat Res Inst, Tokyo, Japan | ; Shen, Yuchen/AAO-4015-2020; Im, Seock-Ah/J-5620-2012; Nishijima, Soichiro/KVA-8556-2024 | 7404185723; 15045889800; 55557484600; 28267963400; 35273175600; 17137276100; 57190793908; 7404589280; 56201175700; 34570185300; 57196305473; 7405478996; 59173400600; 58104130200; 59173400700; 35300852000; 8883149900; 6603929242 | tsurutaj@med.showa-u.ac.jp; | BREAST CANCER | BREAST CANCER-TOKYO | 1340-6868 | 1880-4233 | 31 | 5 | SCIE | OBSTETRICS & GYNECOLOGY;ONCOLOGY | 2024 | 2.9 | 18.2 | 1.32 | 2025-05-07 | 6 | 5 | Advanced breast cancer; Asia; HER2-low; Interstitial lung disease; Trastuzumab deruxtecan | OPEN-LABEL | Advanced breast cancer; Asia; HER2-low; Interstitial lung disease; Trastuzumab deruxtecan | Adult; Aged; Antineoplastic Agents, Immunological; Asian People; Breast Neoplasms; Camptothecin; Female; Humans; Immunoconjugates; Middle Aged; Progression-Free Survival; Receptor, ErbB-2; Trastuzumab; aminotransferase; capecitabine; eribulin; gemcitabine; paclitaxel; trastuzumab deruxtecan; antibody conjugate; camptothecin; epidermal growth factor receptor 2; ERBB2 protein, human; immunological antineoplastic agent; trastuzumab; trastuzumab deruxtecan; adult; adverse outcome; aged; alopecia; anemia; Article; Asian; cancer chemotherapy; cancer survival; constipation; controlled study; decreased appetite; disease severity; drug choice; drug efficacy; drug safety; fatigue; female; gastrointestinal disease; geographic distribution; hematologic disease; human; human epidermal growth factor receptor 2 low metastatic breast cancer; human epidermal growth factor receptor 2 low metastatic breast cancer; incidence; injection site reaction; interstitial lung disease; leukopenia; lymphatic system disease; major clinical study; male; metabolic disorder; metastatic breast cancer; nausea; neutropenia; nutritional disorder; overall survival; phase 3 clinical trial; physician; pneumonia; progression free survival; randomized controlled trial; side effect; skin disease; survival rate; thrombocytopenia; total quality management; treatment duration; vomiting; Asian; breast tumor; clinical trial; comparative study; drug therapy; metabolism; middle aged; mortality; multicenter study; pathology | English | 2024 | 2024-09 | 10.1007/s12282-024-01600-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Development of pH-Sensitive intelligent films incorporating betacyanin from dragon fruit peel and TiO2 nanoparticles for monitoring fish fillet freshness | This study aimed to develop novel pH-sensitive intelligent films for monitoring food freshness by incorporating betacyanin extracted from dragon fruit peel, pectin, sodium alginate, and titanium dioxide (TiO2) nanoparticles. Pectin and betacyanin were simultaneously extracted from dragon fruit peel and combined with sodium alginate and TiO2 nanoparticles to create composite and double-layer films. The films were comprehensively characterized to evaluate their physical, mechanical, structural, and functional properties. Additionally, their effectiveness in monitoring the freshness of mackerel fillets was assessed. The incorporation of TiO2 nanoparticles significantly enhanced film properties, with tensile strength increasing from 3.55-13.42 MPa to 13.85-14.90 MPa, water vapor permeability decreasing from 1.58 to 3.00 x 10-9 g/msPa to 1.54-3.00 x 10-9 g/msPa, and swelling degree reducing from 294-330% to 260-261%. TiO2 nanoparticles effectively immobilized and protected betacyanin from photodegradation, crucial for maintaining color stability. The subjected films demonstrated color changes from reddishviolet to brownish-yellow, correlating with increasing TVB-N levels in mackerel fillets. The double-layer film exhibited superior stability under both dark and light conditions compared to the composite film. This study uniquely combines dragon fruit peel-derived pectin and betacyanin with TiO2 nanoparticles, addressing the growing demand for eco-friendly packaging solutions by utilizing food waste and developing biodegradable alternatives to synthetic pH indicators. | Du, Huimin; Said, Nurul Saadah; Lee, Won-Young | Kyungpook Natl Univ, Sch Food Sci & Technol, Daegu 702701, South Korea; Kyungpook Natl Univ, Res Inst Tailored Food Technol, Daegu 41566, South Korea | ; Lee, Wonyoung/AAL-2780-2021; Said, Nurul Saadah/LFV-3208-2024; Niu, Bailin/AAA-3311-2019 | 59004196400; 57211398275; 57195940408 | wonyoung@knu.ac.kr; | SUSTAINABLE CHEMISTRY AND PHARMACY | SUSTAIN CHEM PHARM | 2352-5541 | 42 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENVIRONMENTAL SCIENCES;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2024 | 5.8 | 18.3 | 0.68 | 2025-05-07 | 2 | 3 | Betacyanin; TiO 2 nanoparticles; Composite film; Double-layer film; Color stability; Freshness indicator | MACKEREL SCOMBER-JAPONICUS; SHELF-LIFE; BARRIER PROPERTIES; TITANIUM-DIOXIDE; PECTIN; ANTHOCYANINS; BETALAINS; EXTENSION; SPOILAGE; CHITOSAN | Betacyanin; Color stability; Composite film; Double-layer film; Freshness indicator; TiO<sub>2</sub> nanoparticles | alginic acid; betacyanin; titanium dioxide; Article; cell membrane permeability; controlled study; film thickness; fish fillet; food waste; Fourier transform infrared spectroscopy; green chemistry; Hylocereus undatus; molecular weight; nonhuman; photodegradation; processed food; tensile strength; water vapor | English | 2024 | 2024-12 | 10.1016/j.scp.2024.101839 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
페이지 이동: