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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | One-step synthesis of a robust, ultrathin, stretchable antifogging copolymer film | Recent advances in wearable and embeddable displays have led to an increase in demand for functional coatings that are stretchable and also retain high optical transparency in fogging conditions. Herein, a conformal antifogging polymer thin film with exceptional stretchability was synthesized in a one-step manner using initiated chemical vapor deposition (iCVD). A series of polymer films were generated by copolymerization of a soft, hydrophilic 2-hydroxyethyl acrylate (HEA) together with a small fraction of a crosslinker 1,3,5-trivinyl-1,3,5-trimethylcyclotrisiloxane (V3D3). The composition of the film was precisely adjusted by controlling the flow rates of the input monomers in the vapor-phase deposition process to yield conformal hydrophilic antifogging films. Unlike conventional antifogging films that often lack mechanical durability due to excessive swelling, the iCVD-based antifogging polymer film offers the means to modulate the extent of crosslinking to achieve an excellent antifogging performance while imparting high elasticity with an elastic limit exceeding 300%. Detailed investigation of the antifogging performance and the mechanical properties through repeated cyclic stress-strain tests on sets of films with different compositions revealed that, in comparison to the commercial antifogging spray coating, the optimal iCVD-based antifogging copolymer film (pH8V1) maintains a high transmittance (>99%) upon exposure to hot water vapor, in the cold-fog transition test, and even in a stretched state. | Ryu, Jin; Oh, Myung Seok; Yoon, Jongsun; Kang, Minjeong; You, Jae Bem; Lee, Hyomin; Im, Sung Gap | Korea Adv Inst Sci & Technol KAIST, Dept Chem & Biomol Engn, Daejeon 34141, South Korea; Korea Res Inst Chem Technol KRICT, Interface Mat & Chem Engn Res Ctr, Daejeon 34141, South Korea; Pohang Univ Sci & Technol POSTECH, Dept Chem Engn, Pohang 37673, South Korea; Kyungpook Natl Univ, Dept Chem Engn, Daegu 41566, South Korea | ; You, Jae/C-6211-2019; Lee, Hyomin/AAW-6694-2021; Im, Sung/C-1823-2011 | 57216800251; 55620340500; 57204804345; 57204677368; 55619455300; 57131701900; 14420979700 | hyomin@postech.ac.kr;sgim@kaist.ac.kr; | JOURNAL OF MATERIALS CHEMISTRY C | J MATER CHEM C | 2050-7526 | 2050-7534 | 11 | 13 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2023 | 5.7 | 19.3 | 0.89 | 2025-06-25 | 9 | 8 | Chemical vapor deposition; Crosslinking; Hydrophilicity; Protective coatings; Semiconducting films; Strain; Thin films; Antifogging; Condition; Copolymer films; Functional coating; Hydrophilics; Initiated chemical vapor depositions; One step synthesis; Optical transparency; Performance; Ultra-thin; Polymer films | English | 2023 | 2023-03-30 | 10.1039/d2tc04838h | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | Should Airway Interstitial Fluid Be Used to Evaluate the Pharmacokinetics of Macrolide Antibiotics for Dose Regimen Determination in Respiratory Infection? | Macrolide antibiotics are important drugs to combat infections. The pharmacokinetics (PK) of these drugs are essential for the determination of their optimal dose regimens, which affect antimicrobial pharmacodynamics and treatment success. For most drugs, the measurement of their concentrations in plasma/serum is the surrogate for drug concentrations in target tissues for therapy. However, for macrolides, simple reliance on total or free drug concentrations in serum/plasma might be misleading. The macrolide antibiotic concentrations of serum/plasma, interstitial fluid (ISF), and target tissue itself usually yield very different PK results. In fact, the PK of a macrolide antibiotic based on serum/plasma concentrations alone is not an ideal predictor for the in vivo efficacy against respiratory pathogens. Instead, the PK based on drug concentrations at the site of infection or ISF provide much more clinically relevant information than serum/plasma concentrations. This review aims to summarize and compare/discuss the use of drug concentrations of serum/plasma, airway ISF, and tissues for computing the PK of macrolides. A better understanding of the PK of macrolide antibiotics based on airway ISF concentrations will help optimize the antibacterial dose regimen as well as minimizing toxicity and the emergence of drug resistance in clinical practice. | Wang, Jianzhong; Zhou, Xueying; Elazab, Sara T.; Park, Seung-Chun; Hsu, Walter H. | Shanxi Agr Univ, Coll Vet Med, Shanxi Key Lab Modernizat TCVM, Jinzhong 030810, Peoples R China; China Agr Univ, Coll Vet Med, Dept Vet Clin Sci, Beijing 100107, Peoples R China; Mansoura Univ, Fac Vet Med, Dept Pharmacol, Mansoura 35516, Egypt; Kyungpook Natl Univ, Coll Vet Med, Lab Vet Pharmacokinet & Pharmacodynam, Daegu 41566, South Korea; Iowa State Univ, Coll Vet Med, Dept Biomed Sci, Ames, IA 50011 USA | ; Elazab, Sara/L-8955-2018; Park, Seung-Chun/AAV-3388-2021; Wang, Jianzhong/AAT-2933-2021 | 57190407640; 57216962825; 57195244229; 7501832396; 7402002883 | whsu@iastate.edu; | ANTIBIOTICS-BASEL | ANTIBIOTICS-BASEL | 2079-6382 | 12 | 4 | SCIE | INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY | 2023 | 4.3 | 19.3 | 0.07 | 2025-06-25 | 1 | 1 | serum; plasma concentrations; interstitial concentrations; tissue concentrations; pharmacokinetics; macrolide antibiotics | IN-VITRO ACTIVITY; EPITHELIAL LINING FLUID; LUNG-TISSUE; BRONCHOALVEOLAR CELLS; PULMONARY DISPOSITION; ANTIMICROBIAL AGENTS; DRUG CONCENTRATIONS; RHODOCOCCUS-EQUI; BRONCHIAL FLUID; BODY-FLUIDS | interstitial concentrations; macrolide antibiotics; pharmacokinetics; serum/plasma concentrations; tissue concentrations | antibiotic agent; azithromycin; clarithromycin; macrolide; tulathromycin; airway; antibacterial activity; antibiotic resistance; clinical practice; drug bioavailability; drug delivery system; drug dose regimen; drug therapy; epithelial lining fluid; human; infectious agent; interstitial fluid; microdialysis; nonhuman; pharmacodynamics; pharmacokinetics; respiratory tract infection; Review; target tissue; volume of distribution | English | 2023 | 2023-04 | 10.3390/antibiotics12040700 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Anti-Cancer Effect of Neural Stem Cells Transfected with Carboxylesterase and sTRAIL Genes in Animals with Brain Lesions of Lung Cancer | A metastatic brain tumor is the most common type of malignancy in the central nervous system, which is one of the leading causes of death in patients with lung cancer. The purpose of this study is to evaluate the efficacy of a novel treatment for metastatic brain tumors with lung cancer using neural stem cells (NSCs), which encode rabbit carboxylesterase (rCE) and the secretion form of tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL). rCE and/or sTRAIL were transduced in immortalized human fetal NSCs, HB1.F3. The cytotoxic effects of the therapeutic cells on human lung cancer cells were evaluated in vitro with the ligands and decoy receptor expression for sTRAIL in the presence of CPT-11. Human NSCs encoding rCE (F3.CE and F3.CE.sTRAIL) significantly inhibited the growth of lung cancer cells in the presence of CPT-11 in vitro. Lung cancer cells were inoculated in immune-deficient mice, and therapeutic cells were transplanted systematically through intracardiac arterial injection and then treated with CPT-11. In resting state, DR4 expression in lung cancer cells and DcR1 in NSCs increased to 70% and 90% after CPT-11 addition, respectively. The volumes of the tumors in immune-deficient mice were reduced significantly in mice with F3.CE.sTRAIL transplantation and CPT-11 treatment. The survival was also significantly prolonged with treatment with F3.sTRAIL and F3.CE plus CPT-11 as well as F3.CE.sTRAIL plus CPT-11. NSCs transduced with rCE and sTRAIL genes showed a significant anti-cancer effect on brain metastatic lung cancer in vivo and in vitro, and the effect may be synergistic when rCE/CPT-11 and sTRAIL are combined. This stem-cell-based study using two therapeutic genes of different biological effects can be translatable to clinical application. | Kim, Jung Hak; Ahn, Jae Sung; Lee, Dong-Seok; Hong, Seok Ho; Lee, Hong J. | Humetacell Inc, Res Inst, Bucheon Si 14786, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Neurosurg, Seoul 05505, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat Biores Grp, Daegu 41566, South Korea; Chungbuk Natl Univ, Coll Med, Cheongju 28644, South Korea; Chungbuk Natl Univ, Med Res Inst, Cheongju 28644, South Korea | lee, wj/JNR-4926-2023 | 55671187300; 57195917471; 57210068061; 57203319535; 35215736300 | hongsound@gmail.com;leehj71@gmail.com; | PHARMACEUTICALS | PHARMACEUTICALS-BASE | 1424-8247 | 16 | 8 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2023 | 4.3 | 19.4 | 0.32 | 2025-06-25 | 2 | 2 | brain metastatic lung cancer; cell-based gene therapy; carboxylesterase (CE); secreted tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL) | ENZYME/PRODRUG THERAPY; ANTITUMOR-ACTIVITY; APOPTOSIS; METASTASES; IRINOTECAN; TARGET; CPT-11; APO2L/TRAIL; DELIVER; LIGAND | brain metastatic lung cancer; carboxylesterase (CE); cell-based gene therapy; secreted tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL) | carboxylesterase; death receptor 4; death receptor 5; DNA topoisomerase inhibitor; irinotecan; tumor necrosis factor related apoptosis inducing ligand; A-549 cell line; animal experiment; animal model; animal tissue; antineoplastic activity; apoptosis; Article; brain damage; cell survival; coculture; comparative effectiveness; controlled study; cytotoxicity; enzyme linked immunosorbent assay; gene; human; human cell; in vitro study; in vivo study; intraarterial drug administration; lung cancer; mouse; NCI-H460 cell line; neural stem cell; nonhuman; reverse transcription polymerase chain reaction; sTRAIL Gene | English | 2023 | 2023-08 | 10.3390/ph16081156 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Antiplatelet Aggregation Properties of Cirsilineol: A Novel Inhibitor of Blood Coagulation Factor Xa | A small natural substance called cirsilineol (CSL), which was discovered in the plant Artemisia vestita, is lethal to many cancer cells and has antioxidant, anticancer, and antibacterial properties. Here, we investigated the underlying mechanisms of the antithrombotic action of CSL. We demonstrated that CSL has antithrombotic efficacy comparable to rivaroxaban, a direct blood coagulation factor Xa (FXa) inhibitor employed as a positive control, in inhibiting the enzymatic activity of FXa and the platelet aggregation induced by adenosine diphosphate (ADP) and U46619, a thromboxane A2 analog. The expression of P-selectin, the phosphorylation of myristoylated alanine-rich C kinase substrate by U46619 or ADP, and the activation of PAC-1 in platelets were inhibited by CSL. Nitric oxide production was increased by CSL in ADP- or U46619-treated human umbilical vein endothelial cells (HUVECs), although excessive endothelin-1 secretion was suppressed. CSL demonstrated strong anticoagulant and antithrombotic effects in a mouse model of arterial and pulmonary thrombosis. Our findings suggest that CSL is a potential pharmacological candidate for a novel class of anti-FXa and antiplatelet medications. | Kim, Go Oun; Heo, Jong Beom; Park, Dong Ho; Song, Gyu Yong; Bae, Jong-Sup | Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu 41566, South Korea; Chungnam Natl Univ, Coll Pharm, 99 Daehak Ro, Daejon 34134, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Ophthalmol, Daegu 41944, South Korea | Bae, Jong-Sup/AAU-9724-2020 | 57896809800; 57414219300; 36676632900; 7402253074; 16021543200 | rhdns9231@gmail.com;songmeom@gmail.com;dongho_park@knu.ac.kr;gysong@cnu.ac.kr;baejs@knu.ac.kr; | PHARMACEUTICALS | PHARMACEUTICALS-BASE | 1424-8247 | 16 | 4 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2023 | 4.3 | 19.4 | 0.97 | 2025-06-25 | 4 | 6 | cirsilineol; FXa; platelet aggregation; thrombosis | ORAL ANTICOAGULANTS; PLATELET ACTIVATION; P-SELECTIN; IN-VITRO; ANTI-IIA; RIVAROXABAN; METAANALYSIS; ENDOTHELIN; THROMBOSIS | cirsilineol; FXa; platelet aggregation; thrombosis | 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid; adenosine diphosphate; blood clotting factor 10a; blood clotting factor 10a inhibitor; calcium; cirsilineol; collagen; dual specificity phosphatase 2; endothelin 1; epinephrine; ferric chloride; flavone; nitric oxide; PADGEM protein; rivaroxaban; unclassified drug; activated partial thromboplastin time; acute disease; adult; amidolytic activity; animal experiment; animal model; antiplatelet aggregation; artery thrombosis; Article; bioassay; blood clotting time; cell viability assay; coagulation assay; controlled study; drug activity; enzyme activity; enzyme kinetics; enzyme linked immunosorbent assay; female; ferric chloride-induced thrombosis; flow cytometry; fluorescence intensity; human; human cell; human experiment; HUVEC cell line; lung parenchyma; male; mouse; MTT assay; nonhuman; normal human; platelet aggregation assay; polyacrylamide gel electrophoresis; protein expression; protein phosphorylation; prothrombin time; pulmonary thrombosis; spectrophotometry; thrombocyte aggregation; thrombocyte poor plasma; Western blotting | English | 2023 | 2023-04 | 10.3390/ph16040588 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Efficient identification of palatability-related genes using QTL mapping in rice breeding | The gelatinization temperature of rice is an important factor in determining the eating and cooking quality, and it affects consumer preference. The alkali digestion value (ADV) is one of the main methods used to test the quality of rice and has a high correlation with the gelatinization temperature. For the development of high-quality rice, it is important to understand the genetic basis of palatability-related traits, and QTL analysis is a statistical method linking phenotypic data and genotype data and is an effective method to explain the genetic basis of variation in complex traits. QTL mapping related to the ADV of brown and milled rice was performed using the 120 Cheongcheong/Nagdong double haploid (CNDH) line. As a result, 12 QTLs related to ADV were detected, and 20 candidate genes were selected from the RM588-RM1163 region of chromosome 6 through screening by gene function analysis. The comparison of the relative expression level of candidate genes showed that OsSS1q6 is highly expressed in CNDH lines with high ADV in both brown rice and milled rice. In addition, OsSS1q6 has high homology with the starch synthase 1 protein and interacts with various starch biosynthesis-related proteins, such as GBSSII, SBE, and APL. Therefore, we suggest that OsSS1q6 identified through QTL mapping could be one of the various genes involved in the gelatinization temperature of rice by regulating starch biosynthesis. This study can be used as basic data for breeding high-quality rice and provides a new genetic resource that can increase the palatability of rice. | Jang, Yoon-Hee; Park, Jae-Ryoung; Kim, Eun-Gyeong; Jan, Rahmatullah; Asif, Saleem; Farooq, Muhammad; Zhao, Dan-Dan; Kim, Kyung-Min | Kyungpook Natl Univ, Coastal Agr Res Inst, Daegu 41566, South Korea; Rural Dev Adm, Natl Inst Crop Sci, Crop Breeding Div, Wonju 55365, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Rural Dev Adm, Natl Inst Crop Sci, Crop Fdn Res Div, Wonju 55365, South Korea | ; Kim, Kyung-Min Kim/C-7007-2014; ZHAO, DANDAN/HIK-2130-2022; Jan, Rahmatullah/AIC-3439-2022 | 57219901992; 57211205505; 57221496070; 57201981969; 57396413700; 57215544380; 57459517300; 34868260300 | uniunnie@naver.com;icd0192@korea.kr;dkqkxk632@naver.com;rehmatbot@yahoo.com;mfarooqsr@gmail.com;zhaodandan@korea.kr;kkm@knu.ac.kr; | MOLECULAR BREEDING | MOL BREEDING | 1380-3743 | 1572-9788 | 43 | 5 | SCIE | AGRONOMY;GENETICS & HEREDITY;HORTICULTURE;PLANT SCIENCES | 2023 | 2.6 | 19.4 | 0.15 | 2025-06-25 | 1 | 1 | Rice; Eating and cooking quality; Alkali digestion value; QTL; Breeding | QUANTITATIVE TRAIT LOCI; STARCH SYNTHASE; EATING QUALITY; GRAIN QUALITY; GELATINIZATION TEMPERATURE; PHYSICOCHEMICAL PROPERTIES; PASTING PROPERTIES; AMYLOPECTIN; AMYLOSE; COOKING | Alkali digestion value; Breeding; Eating and cooking quality; QTL; Rice | Biochemistry; Biosynthesis; Gelation; Mapping; Proteins; Quality control; Starch; Alkali digestion; Alkali digestion value; Breeding; Cooking quality; Eating quality; Gelatinization temperature; High quality; QTL; QTL mapping; Rice; Genes | English | 2023 | 2023-05 | 10.1007/s11032-023-01392-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Established Immortalized Cavernous Endothelial Cells Improve Erectile Dysfunction in Rats with Cavernous Nerve Injury | The main cause of erectile dysfunction (ED) is the damage in penile cavernous endothelial cells (EC). Murine primary ECs have a limited growth potential, and the easy availability of murine ECs will facilitate the study of cavernous endothelial dysfunction in rats. This study was performed to establish immortalized rat penile cavernous ECs (rEC) and investigate how they could repair erectile dysfunction in rats with cavernous nerve injury (CNI). rEC was isolated enzymatically by collagenase digestion and were cultured. An amphotropic replication-incompetent retroviral vector encoding v-myc oncogene was used to transfect rEC for immortalization (vREC). Morphological and immunohistochemical properties of vREC were examined. Eight-week-old male Sprague-Dawley rats were divided into three groups of five rats each, including group 1 = sham operation, group 2 = bilateral CN injury, group 3 = vREC (1 x 10(6) cells) treatment after CNI. Erectile response was assessed at 2, 4 weeks after transplantation of vREC., Penile tissue were harvested at 4 weeks after transplantation and immune-histochemical examination was performed. vREC showed the expression of CD31, vWF, cell type-specific markers for EC by RT-PCR and flowcytometry. At 2, 4 weeks after transplantation, rats with CNI had significantly lower erectile function than control group (p < 0.05). The group transplanted with vREC showed higher erectile function than the group without vRECs (p < 0.05). vREC was established and repaired erectile dysfunction in rats with CNI. This cell line may be useful for studying mechanisms and drug screening of erectile dysfunction of rats. | Bak, Sang Hong; Kim, Jae Heon; Kim, Seung U.; Lee, Dong-Seok; Song, Yun Seob; Lee, Hong J. | Humetacell Inc, Res Inst, Bucheon 14786, Gyeonggi, South Korea; Soonchunhyang Univ, Sch Med, Dept Urol, Seoul 04401, South Korea; Univ British Columbia, UBC Hosp, Dept Med, Div Neurol, Vancouver, BC V6T 2B5, Canada; Kyungpook Natl Univ, Sch Life Sci, BK21 Plus KNU Creat BioRes Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci & Biotechnol, Daegu 41566, South Korea; Chungbuk Natl Univ, Med Res Inst, Cheongju 28644, Chungbuk, South Korea | Kim, Sun Jung/AAM-7334-2020; lee, wj/JNR-4926-2023 | 57987460000; 7601373772; 56467692500; 57210068061; 56942627900; 35215736300 | yssong@schmc.ac.kr;leehj71@gmail.com;leehj71@chungbuk.ac.kr; | PHARMACEUTICALS | PHARMACEUTICALS-BASE | 1424-8247 | 16 | 1 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2023 | 4.3 | 19.4 | 0.16 | 2025-06-25 | 1 | 1 | erectile dysfunction; endothelial cells; v-myc | NEURAL STEM-CELLS; CORPUS CAVERNOSUM; EXPRESSION; TISSUE; BRAIN; GENE; PHOSPHODIESTERASE; ANGIOPOIETINS; ANGIOGENESIS; ENDOGLIN | endothelial cells; erectile dysfunction; v-myc | endoglin; platelet endothelial cell adhesion molecule 1; vasculotropin receptor 1; vasculotropin receptor 2; von Willebrand factor; animal cell; animal experiment; animal model; animal tissue; Article; cavernous endothelial cell; cavernous nerve injury; controlled study; corpus cavernosum; endothelium cell; erectile dysfunction; flow cytometry; intracavernous pressure; keratinocyte cell line; male; nerve injury; nonhuman; penis erection; rat; reverse transcription polymerase chain reaction | English | 2023 | 2023-01 | 10.3390/ph16010123 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Heavy Metal-Based Nanoparticles as High-Performance X-ray Computed Tomography Contrast Agents | X-ray computed tomography (CT) contrast agents offer extremely valuable tools and techniques in diagnostics via contrast enhancements. Heavy metal-based nanoparticles (NPs) can provide high contrast in CT images due to the high density of heavy metal atoms with high X-ray attenuation coefficients that exceed that of iodine (I), which is currently used in hydrophilic organic CT contrast agents. Nontoxicity and colloidal stability are vital characteristics in designing heavy metal-based NPs as CT contrast agents. In addition, a small particle size is desirable for in vivo renal excretion. In vitro phantom imaging studies have been performed to obtain X-ray attenuation efficiency, which is a critical parameter for CT contrast agents, and the imaging performance of CT contrast agents has been demonstrated via in vivo experiments. In this review, we focus on the in vitro and in vivo studies of various heavy metal-based NPs in pure metallic or chemical forms, including Au, Pt, Pd, Ag, Ce, Gd, Dy, Ho, Yb, Ta, W, and Bi, and provide an outlook on their use as high-performance CT contrast agents. | Ahmad, Mohammad Yaseen; Liu, Shuwen; Tegafaw, Tirusew; Saidi, Abdullah Khamis Ali Al; Zhao, Dejun; Liu, Ying; Nam, Sung-Wook; Chang, Yongmin; Lee, Gang Ho | Kyungpook Natl Univ, Coll Nat Sci, Dept Chem, Taegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Taegu 41944, South Korea | ; Ahmad, Mohammad/AAH-2164-2020; Nam, Sung-Wook/V-5519-2019 | 57203054570; 57208926248; 55983618600; 57217492867; 57222567792; 57221731093; 16167127700; 7501840633; 7404851841 | yaseen.knu@gmail.com;liushuwen0701@gmail.com;tegafawtirusew@yahoo.com;abdullah_al_saidi@hotmail.com;djzhao.chem@gmail.com;ly1124161@gmail.com;nams@knu.ac.kr;ychang@knu.ac.kr;ghlee@mail.knu.ac.kr; | PHARMACEUTICALS | PHARMACEUTICALS-BASE | 1424-8247 | 16 | 10 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2023 | 4.3 | 19.4 | 0.84 | 2025-06-25 | 14 | 16 | heavy metal-based nanoparticles; X-ray attenuation; contrast agents; in vitro phantom imaging; in vivo imaging | COATED GOLD NANOPARTICLES; ATTENUATION PROPERTIES; OXIDE NANOPARTICLES; BISMUTH NANOPARTICLES; MESOPOROUS PLATINUM; FACILE SYNTHESIS; LARGE-SCALE; BLOOD-POOL; CT; TOXICITY | contrast agents; heavy metal-based nanoparticles; in vitro phantom imaging; in vivo imaging; X-ray attenuation | cerium oxide nanoparticle; contrast medium; gadolinium; gold nanoparticle; iodine; lanthanide; metal nanoparticle; platinum; silver nanoparticle; tantalum; attenuation; biocompatibility; biomineralization; cell viability; computer assisted tomography; contrast enhancement; cytotoxicity; drug synthesis; fluorescence imaging; histology; human; hydrophilicity; image quality; in vivo study; micro-computed tomography; mouse; multimodal imaging; nanofabrication; nonhuman; nuclear magnetic resonance imaging; particle size; photodynamic therapy; photothermal therapy; radiation attenuation; Review; systematic review; transmission electron microscopy; X ray; x-ray computed tomography | English | 2023 | 2023-10 | 10.3390/ph16101463 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Life-threatening esophageal perforation due to blister pack ingestion | Most ingested foreign bodies do not cause serious complications. In rare cases, elderly people with cognitive de-cline may unintentionally swallow a blister pack while trying to take medicine. When a blister pack is separated into individual parts, the separated parts have sharp edges that can cause serious damage if ingested. We report a case of an elderly patient who unintentionally ingested a blister pack, which led to esophageal perforation and ultimately his death.(C) 2022 Elsevier Inc. All rights reserved. | Yu, Byunghyuk; Yeo, In Hwan; Park, Ji Yeon | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Intens Care Unit, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Emergency Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Gastr Canc Ctr, Sch Med,Dept Surg, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Emergency Med, 807 Hoguk Ro, Daegu 41404, South Korea | Park, Ji Yeon/AAV-2471-2020; Yeo, Inhwan/GXZ-7024-2022; Yu, Byunghyuk/HGB-0950-2022 | 57208745241; 57216816807; 57196405216 | inani1113@gmail.com; | AMERICAN JOURNAL OF EMERGENCY MEDICINE | AM J EMERG MED | 0735-6757 | 1532-8171 | 65 | SCIE | EMERGENCY MEDICINE | 2023 | 2.7 | 19.4 | 0.76 | 2025-06-25 | 3 | 2 | Foreign body; Esophagus; Esophageal perforations | MANAGEMENT | Esophageal perforations; Esophagus; Foreign body | Aged; Cognitive Dysfunction; Eating; Esophageal Perforation; Foreign Bodies; Humans; Medicine; abdominal pain; accidental injury; aged; Article; artificial ventilation; brain infarction; case report; clinical article; cognitive defect; computer assisted tomography; death; debridement; diabetes mellitus; drug packaging; drug use; emergency surgery; emergency ward; enteric feeding; esophagus perforation; extubation; foreign body aspiration; hemodialysis; hospital readmission; human; hypertension; ingestion; intensive care unit; jejunostomy; kidney injury; laparotomy; lavage; life sustaining treatment; male; melena; multiple organ failure; patient referral; pleura effusion; postoperative period; retroperitoneal abscess; surgeon; swallowing; thorax radiography; treatment withdrawal; cognitive defect; complication; eating; esophagus perforation; foreign body; medicine | English | 2023 | 2023-03 | 10.1016/j.ajem.2022.12.031 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Manganese (II) Complex of 1,4,7-Triazacyclononane-1,4,7-Triacetic Acid (NOTA) as a Hepatobiliary MRI Contrast Agent | Magnetic resonance imaging (MRI) is increasingly used to diagnose focal and diffuse liver disorders. Despite their enhanced efficacy, liver-targeted gadolinium-based contrast agents (GBCAs) raise safety concerns owing to the release of toxic Gd3+ ions. A pi-conjugated macrocyclic chelate, Mn-NOTA-NP, was designed and synthesized as a non-gadolinium alternative for liver-specific MRI. Mn-NOTA-NP exhibits an r(1) relaxivity of 3.57 mM(-1) s(-1) in water and 9.01 mM(-1) s(-1) in saline containing human serum albumin at 3 T, which is significantly greater than the clinically utilized Mn2+-based hepatobiliary drug, Mn-DPDP (1.50 mM(-1) s(-1)), and comparable with that of GBCAs. Furthermore, the in vivo biodistribution and MRI enhancement patterns of Mn-NOTA-NP were similar to those of the Gd3+-based hepatobiliary agent, Gd-DTPA-EOB. Additionally, a 0.05 mmol/kg dose of Mn-NOTA-NP facilitated high-sensitivity tumor detection with tumor signal enhancement in a liver tumor model. Ligand-docking simulations further indicated that Mn-NOTA-NP differed from other hepatobiliary agents in their interactions with several transporter systems. Collectively, we demonstrated that Mn-NOTA-NP could be a new liver-specific MRI contrast agent. | Islam, Md. Kamrul; Baek, Ah-Rum; Yang, Byeong-Woo; Kim, Soyeon; Hwang, Dong Wook; Nam, Sung-Wook; Lee, Gang-Ho; Chang, Yongmin | Kyungpook Natl Univ, Inst Biomed Engn Res, Daegu 41405, South Korea; Kyungpook Natl Univ, Sch Med, Dept Med & Biol Engn, Daegu 41944, South Korea; Korea Inst Radiol & Med Sci, Div RI Convergence Res, Seoul 01812, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Chem, 80,Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ Hosp, Dept Radiol, Daegu 41944, South Korea | ; Nam, Sung-Wook/V-5519-2019; Islam, Md. Kamrul/AAE-3221-2021; Islam, Md Kamrul/AAE-3221-2021; Yang, Byeong Woo/HII-8624-2022 | 57193930944; 57194601711; 57195807615; 57203773250; 57749644800; 16167127700; 7404851841; 7501840633 | ychang@knu.ac.kr; | PHARMACEUTICALS | PHARMACEUTICALS-BASE | 1424-8247 | 16 | 4 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2023 | 4.3 | 19.4 | 1.29 | 2025-06-25 | 9 | 8 | magnetic resonance imaging; manganese; contrast agent; naphthalene; liver imaging | GD-EOB-DTPA; GADOLINIUM; ENHANCEMENT; TRANSPORTERS; REPLACEMENT; CONJUGATE; STABILITY; FIBROSIS; PROTEIN | contrast agent; liver imaging; magnetic resonance imaging; manganese; naphthalene | 1 4 7 triazacyclononane 1 4 7 triacetic acid; contrast medium; gadolinium pentetate; human serum albumin; mangafodipir; manganese; metal complex; multidrug resistance associated protein 2; naphthalene; organic compound; sodium chloride; unclassified drug; water; animal cell; animal experiment; animal model; animal tissue; Article; carbon nuclear magnetic resonance; cell viability; cell viability assay; column chromatography; controlled study; cytotoxicity; electrospray mass spectrometry; elemental analysis; Hep-G2 cell line; hepatobiliary system; high performance liquid chromatography; human; human cell; hydrogen bond; image analysis; in vivo study; inductively coupled plasma atomic emission spectrometry; lipophilicity; mouse; nonhuman; nuclear magnetic resonance imaging; pH; proton nuclear magnetic resonance; RAW 264.7 cell line; signal noise ratio; simulation; T1 weighted imaging; thin layer chromatography | English | 2023 | 2023-04 | 10.3390/ph16040602 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Prediction of the Drug-Drug Interaction Potential between Tegoprazan and Amoxicillin/Clarithromycin Using the Physiologically Based Pharmacokinetic and Pharmacodynamic Model | Tegoprazan is a novel potassium-competitive acid blocker. This study investigated the effect of drug-drug interaction on the pharmacokinetics and pharmacodynamics of tegoprazan co-administered with amoxicillin and clarithromycin, the first-line therapy for the eradication of Helicobacter pylori, using physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) modeling. The previously reported tegoprazan PBPK/PD model was modified and applied. The clarithromycin PBPK model was developed based on the model provided by the SimCYP(R) compound library. The amoxicillin model was constructed using the middle-out approach. All of the observed concentration-time profiles were covered well by the predicted profiles with the 5th and 95th percentiles. The mean ratios of predicted to observed PK parameters, including the area under the curve (AUC), maximum plasma drug concentration (C-max), and clearance, were within the 30% intervals for the developed models. Two-fold ratios of predicted fold-changes of C-max and AUC from time 0 to 24 h to observed data were satisfied. The predicted PD endpoints, including median intragastric pH and percentage holding rate at pH above 4 or 6 on day 1 and day 7, were close to the corresponding observed data. This investigation allows evaluation of the effects of CYP3A4 perpetrators on tegoprazan PK and PD changes, thus providing clinicians with the rationale for co-administration dosing adjustment. | Wei, Zhuodu; Jeong, Hyeon-Cheol; Kim, Min-Gul; Shin, Kwang-Hee | Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, 80, Daehak ro, Daegu 41566, South Korea; Jeonbuk Natl Univ, Med Sch, Dept Pharmacol, Jeonju 54907, South Korea | 57764624700; 57196346934; 38260938400; 35216279300 | kshin@knu.ac.kr; | PHARMACEUTICALS | PHARMACEUTICALS-BASE | 1424-8247 | 16 | 3 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2023 | 4.3 | 19.4 | 0.32 | 2025-06-25 | 2 | 2 | tegoprazan; clarithromycin; amoxicillin; PBPK; pharmacodynamics; drug interactions | HELICOBACTER-PYLORI ERADICATION; REGULATORY DECISION-MAKING; COMPETITIVE ACID BLOCKER; THERAPY | amoxicillin; clarithromycin; drug interactions; PBPK; pharmacodynamics; tegoprazan | amoxicillin; clarithromycin; cytochrome P450 3A4; tegoprazan; area under the curve; Article; concentration response; drug absorption; drug clearance; drug distribution; drug elimination; drug interaction; drug metabolism; drug solubility; human; maximum concentration; pH; pharmacodynamics; prediction; single drug dose | English | 2023 | 2023-03 | 10.3390/ph16030360 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Profiling of Secondary Metabolites of Optimized Ripe Ajwa Date Pulp (Phoenix dactylifera L.) Using Response Surface Methodology and Artificial Neural Network | The date palm (Phoenix dactylifera L.) is a popular edible fruit consumed all over the world and thought to cure several chronic diseases and afflictions. The profiling of the secondary metabolites of optimized ripe Ajwa date pulp (RADP) extracts is scarce. The aim of this study was to optimize the heat extraction (HE) of ripe Ajwa date pulp using response surface methodology (RSM) and artificial neural network (ANN) modeling to increase its polyphenolic content and antioxidant activity. A central composite design was used to optimize HE to achieve the maximum polyphenolic compounds and antioxidant activity of target responses as a function of ethanol concentration, extraction time, and extraction temperature. From RSM estimates, 75.00% ethanol and 3.7 h (extraction time), and 67 degrees C (extraction temperature) were the optimum conditions for generating total phenolic content (4.49 +/- 1.02 mgGAE/g), total flavonoid content (3.31 +/- 0.65 mgCAE/g), 2,2-diphenyl-1-picrylhydrazyl (11.10 +/- 0.78 % of inhibition), and cupric-reducing antioxidant capacity (1.43 mu M ascorbic acid equivalent). The good performance of the ANN was validated using statistical metrics. Seventy-one secondary metabolites, including thirteen new bioactive chemicals (hebitol II, 1,2-di-(syringoyl)-hexoside, naringin dihydrochalcone, erythron-guaiacylglycerol-beta-syringaresinol ether hexoside, erythron-1-(4 '-O-hexoside-3,5-dimethoxyphenyl)-2-syrngaresinoxyl-propane-1,3-diol, 2-deoxy-2,3-dehydro-N-acetyl-neuraminic acid, linustatin and 1-deoxynojirimycin galactoside), were detected using high-resolution mass spectroscopy. The results revealed a significant concentration of phytoconstituents, making it an excellent contender for the pharmaceutical and food industries. | Alshammari, Fanar; Alam, Md Badrul; Naznin, Marufa; Javed, Ahsan; Kim, Sunghwan; Lee, Sang-Han | Kyungpook Natl Univ, Grad Sch, Dept Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Food & Bioind Res Inst, Inner Beauty Antiaging Ctr, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Mass Spectrometry Converging Res Ctr, Daegu 41566, South Korea; Green Nano Mat Res Ctr, Daegu 41566, South Korea | Lee, Seung Eun/ABG-1607-2021; Kim, Sunghwan/HKN-9812-2023; Javed, Ahsan/ABK-2648-2022; Alam, Md Badrul/AFL-7668-2022; ALAM, MD BADRUL/AFL-7668-2022 | 57191860948; 56706777100; 57195955389; 57204433098; 57203772967; 57221453703 | sunghwank@knu.ac.kr;sang@knu.ac.kr; | PHARMACEUTICALS | PHARMACEUTICALS-BASE | 1424-8247 | 16 | 2 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2023 | 4.3 | 19.4 | 1.45 | 2025-06-25 | 8 | 9 | Ajwa dates; antioxidant; artificial neural network; polyphenolics; response surface methodology | ULTRASONIC-ASSISTED EXTRACTION; ANTIOXIDANT ACTIVITY; PHENOLIC-COMPOUNDS; MODEL SELECTION; FRUIT; RSM; ANN; PREVENTION; PREDICTION; GLYCOSIDES | Ajwa dates; antioxidant; artificial neural network; polyphenolics; response surface methodology | 1 deoxynojirimycin galactoside; 1 deoxynojirimycin hexoside; 1,2 di (syringoyl) hexoside; 2 deoxy 2,3 dehydro n acetyl neuraminic acid; 2 hydroxyglutaric acid; 3 methylglutaconic acid; 3 methylglutaric acid; 6' sialyllactose; afzelin gallate; alcohol; allysine; apigenin 8 c (pentosyl) hexoside; aspartic acid; caffeic acid derivative; caffeic acid hexoside; caffeoylshikimic acid; carbohydrate derivative; carboxylic acid; chrysoeriol; chrysoeriol hexosyl sulfate; chrysoeriol rhamnosyl dihexoside; chrysoeriol rhamnosyl hexoside; citric acid; coumalic acid; coumaroyl hexose; dicaffeoyl shikimic acid; dihydrokaempferol hexoside; dihydroxy octadecadienoic acid; dihydroxy octadecenoic acid; erythron 1 (4' o hexoside 3,5 dimethoxyphenyl) 2 syrngaresinoxyl propane 1,3 diol; erythron guaiacylglycerol beta syringaresinol ether hexoside; flavonoid; fumaric acid; galactose; gluconic acid; glutaconic acid; glutaric acid; hebitol II; hexose; hydroxy octadecatrienoic acid; hydroxy octadecenoic acid; hydroxybenzoylhexose; hydroxymethyl glutaric acid; isoquercetin; isoquercitrin sulfate; isorhamnetin diglucoside; isorhamnetin hexoside; isorhamnetin rhamnosyl glucoside; lignan; linoleic acid; linolenic acid; linustatin; luteolin dihexosyl sulfate; luteolin hexosyl sulfate; luteolin rhamnosyl dihexoside; luteolin rhamnosyl hexoside; maltitol; mannitol; n acetyl alpha neuraminic acid; naringin dihydrochalcone; norbellidifodin; oleic acid; oxycoumarin 4 acetic acid methyl ester hexoside; palmitic acid; plant medicinal product; polyphenol; proline; pyroglutamic acid; quercetin; quercetin diglucoside; quercetin rhamnosyl glucoside; ribonic acid; sedoheptulose; sialic acid derivative; trihydroxy octadecadienoic acid; trihydroxy octadecenoic acid; unclassified drug; unsaturated digalacturonate; xylosmaloside; antioxidant activity; Article; artificial neural network; central composite design; chemical parameters; concentration (parameter); cupric reducing antioxidant capacity; date (fruit); DPPH radical scavenging assay; experimental design; extraction temperature; extraction time; mass spectrometry; metabolic fingerprinting; metabolite; nonhuman; predictive model; reproducibility; response surface method; secondary metabolite; total flavonoid content; total phenolic content | English | 2023 | 2023-02 | 10.3390/ph16020319 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Recent Advances in Doxorubicin Formulation to Enhance Pharmacokinetics and Tumor Targeting | Doxorubicin (DOX), a widely used drug in cancer chemotherapy, induces cell death via multiple intracellular interactions, generating reactive oxygen species and DNA-adducted configurations that induce apoptosis, topoisomerase II inhibition, and histone eviction. Despite its wide therapeutic efficacy in solid tumors, DOX often induces drug resistance and cardiotoxicity. It shows limited intestinal absorption because of low paracellular permeability and P-glycoprotein (P-gp)-mediated efflux. We reviewed various parenteral DOX formulations, such as liposomes, polymeric micelles, polymeric nanoparticles, and polymer-drug conjugates, under clinical use or trials to increase its therapeutic efficacy. To improve the bioavailability of DOX in intravenous and oral cancer treatment, studies have proposed a pH- or redox-sensitive and receptor-targeted system for overcoming DOX resistance and increasing therapeutic efficacy without causing DOX-induced toxicity. Multifunctional formulations of DOX with mucoadhesiveness and increased intestinal permeability through tight-junction modulation and P-gp inhibition have also been used as orally bioavailable DOX in the preclinical stage. The increasing trends of developing oral formulations from intravenous formulations, the application of mucoadhesive technology, permeation-enhancing technology, and pharmacokinetic modulation with functional excipients might facilitate the further development of oral DOX. | Lee, Jihoon; Choi, Min-Koo; Song, Im-Sook | Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Vessel Organ Interact Res Ctr VOICE,BK21 FOUR Comm, Daegu 41566, South Korea; Dankook Univ, Coll Pharm, Cheonan 31116, South Korea | 57195979045; 8695781400; 7201564500 | legadema0905@knu.ac.kr;minkoochoi@dankook.ac.kr;isssong@knu.ac.kr; | PHARMACEUTICALS | PHARMACEUTICALS-BASE | 1424-8247 | 16 | 6 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2023 | 4.3 | 19.4 | 3.72 | 2025-06-25 | 55 | 66 | doxorubicin (DOX); formulation strategy; drug resistance; oral formulation | CELL LUNG-CANCER; MESOPOROUS SILICA NANOPARTICLES; ANTI-EGFR IMMUNOLIPOSOMES; P-GLYCOPROTEIN INHIBITOR; GLYCOL 2000 SUCCINATE; DNA TOPOISOMERASE-II; ORAL BIOAVAILABILITY; PHASE-I; DRUG-DELIVERY; LIPOSOMAL DOXORUBICIN | doxorubicin (DOX); drug resistance; formulation strategy; oral formulation | doxorubicin; excipient; liposome; long untranslated RNA; nanoparticle; polymer; polymer drug conjugate; reactive oxygen metabolite; receptor; unclassified drug; biotechnology; cancer chemotherapy; clinical trial (topic); drug bioavailability; drug delivery system; drug dosage form comparison; drug efficacy; drug formulation; drug metabolism; drug targeting; drug transport; first pass effect; gene overexpression; human; hypoglycemia; intestine mucosa permeability; Ion Trapping Phenomenon; malignant neoplasm; micelle; mucoadhesiveness; nonhuman; pH; pharmacokinetics; preclinical study; Review; tight junction; trend study; tumor cell | English | 2023 | 2023-06 | 10.3390/ph16060802 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Adsorption Phenomenon of VOCs Released from the Fiber-Reinforced Plastic Production onto Carbonaceous Surface | The manufacturing of fiber-reinforced plastics has been linked to the discharge of volatile organic compounds (VOCs), particularly toluene and benzene, which have been identified as posing substantial risks to human health and the environment. To counteract this issue, activated carbons have been suggested as a means of reducing VOC emissions through adsorption. The objective of this study was to investigate the adsorption characteristics of toluene and benzene onto activated carbons produced from coal (AC) and coconut shells (CAC). The study was carried out in an aqueous medium. The findings revealed that the AC sample with higher surface characteristics exhibited a higher adsorption capacity (toluene: 196.0784 mg g(-1) and benzene: 181.8182 mg g(-1)) in comparison to the CAC sample (toluene: 135.1351 mg g(-1) and benzene: 116.2791 mg g(-1)). The superior adsorption performance of AC on both VOCs can be attributed to its higher surface characteristics. The Langmuir model was found to be more appropriate than the Freundlich model, as indicated by the higher coefficient of determination (R-2) value of the Langmuir isotherm (avg. R-2 = 0.9669) compared to that of the Freundlich isotherm (avg. R-2 = 0.9654), suggesting the use of a monolayer adsorption mechanism. The adsorption kinetics of the samples were analyzed using the pseudo-first-order and pseudo-second-order models, and the former was found to be more fitting, indicating that the rate of adsorption is directly proportional to the concentration difference between the solution and the sample surface. The adsorption process was found to be spontaneous and favorable based on the positive value of Delta Gₐdₛ. Furthermore, the adsorption process was endothermic and disordered, as indicated by the positive values of Delta Hₐdₛ and Delta Sₐdₛ. The regeneration efficiency of all the samples was secured more than 95% upon the fifth cycle. | Lee, Joon Hyuk; Jeon, Eunkyung; Song, Jung-kun; Son, Yujin; Choi, Jaeho; Khim, Seongjun; Kim, Minju; Nam, Ki-Ho | Agcy Def Dev, POB 35, Daejeon 34186, South Korea; Kyungpook Natl Univ, Dept Text Syst Engn, Daegu 41566, South Korea | Lee, Joon Hyuk/AAS-1755-2020 | 57201905002; 57204466122; 57204465785; 58188303800; 55722492000; 58024968200; 57203466947; 55553181500 | bonbonsucre86@naver.com; | POLYMERS | POLYMERS-BASEL | 2073-4360 | 15 | 7 | SCIE | POLYMER SCIENCE | 2023 | 4.7 | 19.5 | 0.57 | 2025-06-25 | 5 | 6 | volatile organic compound; activated carbon; adsorption; isotherm; kinetics | ACTIVATED CARBON; AQUEOUS-SOLUTION; METHYLENE-BLUE; REMOVAL; BENZENE; KINETICS; IONS | activated carbon; adsorption; isotherm; kinetics; volatile organic compound | Activated carbon; Adsorption; Adsorption isotherms; Benzene; Health risks; Monolayers; Reinforcement; Toluene; Adsorption characteristic; Adsorption phenomena; Adsorption process; Carbonaceous surface; Coconut shells; Plastic production; Positive value; Risk to human health; Surface characteristics; Volatile organic compound emission; Volatile organic compounds | English | 2023 | 2023-04 | 10.3390/polym15071640 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Antibacterial Effects of a Carbon Nitride (CN) Layer Formed on Non-Woven Polypropylene Fabrics Using the Modified DC-Pulsed Sputtering Method | In the present study, the surface of non-woven polypropylene (NW-PP) fabric was modified to form CN layers using a modified DC-pulsed (frequency: 60 kHz, pulse shape: square) sputtering with a roll-to-roll system. After plasma modification, structural damage in the NW-PP fabric was not observed, and the C-C/C-H bonds on the surface of the NW-PP fabric converted into C-C/C-H, C-N(CN), and C=O bonds. The CN-formed NW-PP fabrics showed strong hydrophobicity for H2O (polar liquid) and full-wetting characteristics for CH2I2 (non-polar liquid). In addition, the CN-formed NW-PP exhibited an enhanced antibacterial characteristic compared to NW-PP fabric. The reduction rate of the CN-formed NW-PP fabric was 89.0% and 91.6% for Staphylococcus aureus (ATCC 6538, Gram-positive) and Klebsiella pneumoniae (ATCC4352, Gram-negative), respectively. It was confirmed that the CN layer showed antibacterial characteristics against both Gram-positive and Gram-negative bacteria. The reason for the antibacterial effect of CN-formed NW-PP fabrics can be explained as the strong hydrophobicity due to the CH3 bond of the fabric, enhanced wetting property due to CN bonds, and antibacterial activity due to C=O bonds. Our study presents a one-step, damage-free, mass-productive, and eco-friendly method that can be applied to most weak substrates, allowing the mass production of antibacterial fabrics. | Sohn, Young-Soo; Jung, Sang Kooun; Lee, Sung-Youp; Kim, Hong Tak | Daegu Catholic Univ, Dept Biomed Engn, Gyongsan 38439, South Korea; Econet Korea Ltd, Gumi 39373, South Korea; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea | 7201971337; 7403677056; 14830491400; 7410138212 | sohnys@cu.ac.kr;econetkorea@naver.com;physylee@knu.ac.kr;zam89blue@gmail.com; | POLYMERS | POLYMERS-BASEL | 2073-4360 | 15 | 12 | SCIE | POLYMER SCIENCE | 2023 | 4.7 | 19.5 | 0.46 | 2025-06-25 | 5 | 4 | antibacterial effect; carbon nitride; staphylococcus aureus; klebsiella pneumonia; non-woven fabric; sputtering | PLASMA; ARGON | antibacterial effect; carbon nitride; klebsiella pneumonia; non-woven fabric; sputtering; staphylococcus aureus | Bacteria; Carbon nitride; Hydrophobicity; Nonwoven fabrics; Polypropylenes; Substrates; Weaving; Wetting; Antibacterial effects; Antibacterials; Gram positive; Klebsiella pneumoniae; Nitride layers; Non-woven; Non-woven fabric; Pulsed sputtering; Staphylococcus aureus; Woven polypropylene fabrics; Sputtering | English | 2023 | 2023-06 | 10.3390/polym15122641 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Autoencoder-based anomaly detection of industrial robot arm using stethoscope based internal sound sensor | Sound and vibration analysis are prominent tools for machine health diagnosis. Especially, neural network (NN) strategies have focused on finding complex and nonlinear relationships between the sensor signal and the machine status to detect machine faults. However, it is difficult to collect enough amount of fault data as much as normal status data for training general NN models. To resolve the issue, this paper proposes the autoencoder-based anomaly detection framework for industrial robot arms using an internal sound sensor. The autoencoder uses signals in the normal state of the robots for training the model. It reconstructs the input signals as output, and anomalous states are found from high reconstruction error. Two stethoscopes were attached to the surface of the robot joint as sensors, and the sounds were recorded by USB microphone attached to the outlet of the stethoscopes. Features were extracted from STFT spectrogram images of the gathered sound, then used to train and test an autoencoder model. The reconstruction errors of the autoencoder were compared to distinguish the abnormal status from normal one. The experimental results suggest that the stethoscopes prevent the interference of noise, and the collected sound signals can be utilized for detecting machine anomalies. | Yun, Huitaek; Kim, Hanjun; Jeong, Young Hun; Jun, Martin B. G. | Purdue Univ, Sch Mech Engn, W Lafayette, IN 47906 USA; Purdue Univ, Indiana Mfg Competitiveness Ctr MaC, W Lafayette, IN 47906 USA; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea | ; Yun, Huitaek/GQP-1200-2022 | 57196328937; 57209281220; 56501196300; 24587060000 | mbgjun@purdue.edu; | JOURNAL OF INTELLIGENT MANUFACTURING | J INTELL MANUF | 0956-5515 | 1572-8145 | 34 | 3 | SCIE | COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;ENGINEERING, MANUFACTURING | 2023 | 5.9 | 19.5 | 5.47 | 2025-06-25 | 51 | 58 | Sound spectrogram; Autoencoder; Neural network; Stethoscope; Industrial robot arm | FAULT-DIAGNOSIS; WAVELET TRANSFORM; VIBRATION; SYSTEM; CLASSIFICATION; IDENTIFICATION | Autoencoder; Industrial robot arm; Neural network; Sound spectrogram; Stethoscope | Anomaly detection; Fault detection; Industrial robots; Learning systems; Palmprint recognition; Spectrographs; Anomaly detection; Auto encoders; Industrial robot arms; Neural-networks; Reconstruction error; Sound analysis; Sound sensors; Sound spectrogram; Stethoscope; Vibrations analysis; Vibration analysis | English | 2023 | 2023-03 | 10.1007/s10845-021-01862-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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