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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Review | Role of epithelial splicing regulatory protein 1 in cancer progression | As aberrant alternative splicing by either dysregulation or mutations of splicing factors contributes to cancer initiation and progression, splicing factors are emerging as potential therapeutic targets for cancer therapy. Therefore, pharmacological modulators targeting splicing factors have been under development. Epithelial splicing regulatory protein 1 (ESRP1) is an epithelial cell-specific splicing factor, whose downregulation is associated with epithelial-mesenchymal transition (EMT) by regulating alternative splicing of multiple genes, such as CD44, CTNND1, ENAH, and FGFR2. Consistent with the downregulation of ESRP1 during EMT, it has been initially revealed that high ESRP1 expression is associated with favorable prognosis and ESRP1 plays a tumor-suppressive role in cancer progression. However, ESRP1 has been found to promote cancer progression in some cancers, such as breast and ovarian cancers, indicating that it plays a dual role in cancer progression depending on the type of cancer. Furthermore, recent studies have reported that ESRP1 affects tumor growth by regulating the metabolism of tumor cells or immune cell infiltration in the tumor microenvironment, suggesting the novel roles of ESRP1 in addition to EMT. ESRP1 expression was also associated with response to anticancer drugs. This review describes current understanding of the roles and mechanisms of ESRP1 in cancer progression, and further discusses the emerging novel roles of ESRP1 in cancer and recent attempts to target splicing factors for cancer therapy. | Kwon, Mi Jeong | Kyungpook Natl Univ, Coll Pharm, Vessel Organ Interact Res Ctr MRC, Daegu, South Korea; Kyungpook Natl Univ, Coll Pharm, Based Intelligent Novel Drug Discovery Educ Unit, BK21 FOUR KNU Community, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, 80 Daehak Ro, Daegu 41566, South Korea | 35278164800 | mjkwon94@knu.ac.kr; | CANCER CELL INTERNATIONAL | CANCER CELL INT | 1475-2867 | 23 | 1 | SCIE | ONCOLOGY | 2023 | 5.3 | 19.1 | 0.37 | 2025-06-25 | 6 | 6 | Epithelial splicing regulatory protein 1; Alternative splicing; Splicing factor; Epithelial-mesenchymal transition; Dual role; Cancer progression | MESENCHYMAL TRANSITION; TUMOR-SUPPRESSOR; BINDING-PROTEIN; SR PROTEIN; ESRP1; TRANSCRIPTOME; METASTASIS; EVOLUTION; PROGRAM; CELLS | Alternative splicing; Cancer progression; Dual role; Epithelial splicing regulatory protein 1; Epithelial–mesenchymal transition; Splicing factor | epithelial splicing regulatory protein 1; ESRP2 protein; gemcitabine; oligonucleotide; paclitaxel; protein kinase inhibitor; RNA splicing factor; tamoxifen; tg 003; unclassified drug; alternative RNA splicing; cancer growth; cancer prognosis; cancer survival; down regulation; drug sensitivity; drug targeting; epithelial mesenchymal transition; ESRP1 gene; estrogen receptor positive breast cancer; gene; human; nonhuman; protein function; protein processing; Review; RNA processing; treatment response; tumor microenvironment | English | 2023 | 2023-12-18 | 10.1186/s12935-023-03180-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Synergistic apoptosis by combination of metformin and an O-GlcNAcylation inhibitor in colon cancer cells | BackgroundAlthough autophagy is an important mediator of metformin antitumor activity, the role of metformin in the crosstalk between autophagy and apoptosis remains unclear. The aim was to confirm the anticancer effect by inducing apoptosis by co-treatment with metformin and OSMI-1, an inhibitor of O-GlcNAcylation, in colon cancer cells.MethodsCell viability was measured by MTT in colon cancer cell lines HCT116 and SW620 cells. Co-treatment with metformin and OSMI-1 induced autophagy and apoptosis, which was analyzed using western blot, reverse transcription-polymerase chain reaction (RT-PCR) analysis, and fluorescence-activated cell sorting (FACS). Combined treatment with metformin and OSMI-1 synergistically inhibit the growth of HCT116 was confirmed by xenograft tumors.ResultsWe showed that metformin inhibited mammalian target of rapamycin (mTOR) activity by inducing high levels of C/EBP homologous protein (CHOP) expression through endoplasmic reticulum (ER) stress and activating adenosine monophosphate-activated protein kinase (AMPK) to induce autophagy in HCT116 cells. Interestingly, metformin increased O-GlcNAcylation and glutamine:fructose-6-phosphate amidotransferase (GFAT) levels in HCT116 cells. Thus, metformin also blocks autophagy by enhancing O-GlcNAcylation, whereas OSMI-1 increases autophagy via ER stress. In contrast, combined metformin and OSMI-1 treatment resulted in continuous induction of autophagy and disruption of O-GlcNAcylation homeostasis, resulting in excessive autophagic flux, which synergistically induced apoptosis. Downregulation of Bcl2 promoted apoptosis via the activation of c-Jun N-terminal kinase (JNK) and CHOP overexpression, synergistically inducing apoptosis. The activation of IRE1 alpha/JNK signaling by OSMI-1 and PERK/CHOP signaling by metformin combined to inhibit Bcl2 activity, ultimately leading to the upregulation of cytochrome c release and activation of caspase-3.ConclusionsIn conclusion, combinatorial treatment of HCT116 cells with metformin and OSMI-1 resulted in more synergistic apoptosis being induced by enhancement of signal activation through ER stress-induced signaling rather than the cell protective autophagy function. These results in HCT116 cells were also confirmed in xenograft models, suggesting that this combination strategy could be utilized for colon cancer treatment. | Lee, Da Eun; Lee, Geun Yong; Lee, Hae Min; Choi, Soo Young; Lee, Su Jin; Kwon, Oh-Shin | Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea; Hallym Univ, Dept Biomed Sci, Chunchon 24252, South Korea; Hallym Univ, Res Inst Biosci & Biotechnol, Chunchon 24252, South Korea | 57192806145; 58299828900; 58299440000; 56912545700; 57213176234; 7402195859 | oskwon@knu.ac.kr; | CANCER CELL INTERNATIONAL | CANCER CELL INT | 1475-2867 | 23 | 1 | SCIE | ONCOLOGY | 2023 | 5.3 | 19.1 | 2.29 | 2025-06-25 | 17 | 16 | Apoptosis; Autophagy; Colon cancer; ER stress; Metformin; OSMI-1 | ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; ER STRESS; CISPLATIN RESISTANCE; GLCNAC-MODIFICATION; UP-REGULATION; AUTOPHAGY; PHOSPHORYLATION; TRANSCRIPTION; ACTIVATION | Apoptosis; Autophagy; Colon cancer; ER stress; Metformin; OSMI-1 | caspase 3; cytochrome c; glutamine fructose 6 phosphate aminotransferase; glycosyltransferase inhibitor; hydroxymethylglutaryl coenzyme A reductase kinase kinase; mammalian target of rapamycin; metformin; n acetylglucosaminyltransferase; osmi 1; protein IRE1; stress activated protein kinase; unclassified drug; animal cell; animal experiment; animal model; animal tissue; antineoplastic activity; apoptosis; Article; autophagy (cellular); cancer combination chemotherapy; cancer tissue; cell activation; cell protection; cell viability; colon cancer cell line; combination drug therapy; controlled study; cytotoxicity; down regulation; endoplasmic reticulum stress; enzyme activity; female; fluorescence activated cell sorting; gene overexpression; glycosylation; HCT 116 cell line; human; human cell; human tissue; mouse; nonhuman; protein blood level; protein expression; protein homeostasis; reverse transcription polymerase chain reaction; signal transduction; SW620 cell line; synergistic effect; tumor xenograft; upregulation; Western blotting | English | 2023 | 2023-06-02 | 10.1186/s12935-023-02954-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Continuum contact process and influence of impurity on the critical behavior in absorbing-state phase transitions in two dimensions | We study via Monte Carlo simulations the influence of quenched and mobile impurities in the contact process (CP) on two-dimensional lattice and continuum systems. In the lattice system, the effect of mobile impurity was studied for the density ni = 0.2 and two selected values of hopping probability for impurity particles, w = 0.5 and 1. In the continuum system, the CP was defined by distributing spherical impurity particles of diameter cri and number density ni = 0.2 and active particles of diameter unity and number density 1 - ni on a square substrate with periodic boundaries. In each dynamic process, a particle is selected at random; the active particle either creates with a rate lambda an offspring at a distance r (1 r 1.5) from the active particle or annihilates with a unit rate, and the impurity particle hops a distance r (0 r 1), both along randomly selected directions. We found that the lattice CP shows power-law behaviors with varying critical exponents depending on the values of w. For the continuum CP with quenched impurity, the critical behavior followed the activated scaling scenario, whereas with mobile impurity usual power-law behaviors were observed but the critical exponents varied depending on the values of cri. | Lee, Sang Bub; Kim, Jin Min | Soongsil Univ, Dept Phys, Seoul 06978, South Korea; Soongsil Univ, OMEG Inst, Seoul 06978, South Korea; Kyungpook Natl Univ, Daegu 41566, South Korea | 57196249242; 57191681790 | sblee@knu.ac.kr;jmkim@ssu.ac.kr; | PHYSICAL REVIEW E | PHYS REV E | 2470-0045 | 2470-0053 | 108 | 6 | SCIE | PHYSICS, FLUIDS & PLASMAS;PHYSICS, MATHEMATICAL | 2023 | 2.2 | 19.2 | 0 | 2025-06-25 | 0 | 0 | 2-PHASE DISORDERED MEDIA; CELLULAR-AUTOMATA; FIELD-THEORY; MODEL; UNIVERSALITY; RENORMALIZATION; EXTINCTION; SYSTEMS; LATTICE | Intelligent systems; Absorbing-state phase transitions; Active particles; Contact process; Continuum systems; Critical behaviour; Critical exponent; Impurity particles; Lattice system; Number density; Power law behaviour; adult; article; controlled study; Humulus; Monte Carlo method; phase transition; probability; progeny; Monte Carlo methods | English | 2023 | 2023-12-28 | 10.1103/physreve.108.064135 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | How the physical inactivity is affected by social-, economic- and physical-environmental factors: an exploratory study using the machine learning approach | Previous studies have utilized regression models to investigate the impact of environmental factors on physical activity. However, such approaches are inadequate for data-driven analysis seeking to identify robust associations from the intricate and multi-variable interactions between physical activity and environmental factors. With the emergence of the concept of the exposome, which encompasses the totality of exposures, this paper explores machine learning models for predicting the percentage of physical inactivity in U.S. counties, while considering 28 social-, economic-, and physical-environmental factors. The aim of this study is to address the research gap and gain insight into the complex associations between environmental exposures and physical activity. Five machine learning models were tested, and the performances were compared to select the best classifier for further investigation. This study used data from the Behavioral Risk Factor Surveillance System (BRFSS) of the Centers for Disease Control and Prevention. The mean population of all counties was 102,841, and the mean percentage of population below 18 years was 22.3%. The partial dependence plot analysis indicated that only one feature - bachelor's degree - exhibited a close-to-linear relationship with physical inactivity. Motor-vehicle crash death rate and mean temperature showed nonlinear and non-monotonic relationships with the predicted percentage of physical inactivity. | Lee, Kangjae; Wang, Jue; Heo, Joon | Kyungpook Natl Univ, Dept Locat Based Informat Syst, Sangju Si 37224, Gyeongsangbuk D, South Korea; Univ Toronto Mississauga, Dept Geog Geomat & Environm, Mississauga, ON, Canada; Yonsei Univ, Dept Civil & Environm Engn, Seoul, South Korea | ; Heo, Joon/J-8399-2012; Wang, Jue/S-4523-2019 | 56040328200; 56095607400; 8876844400 | kasbiss@knu.ac.kr; | INTERNATIONAL JOURNAL OF DIGITAL EARTH | INT J DIGIT EARTH | 1753-8947 | 1753-8955 | 16 | 1 | SCIE | GEOGRAPHY, PHYSICAL;REMOTE SENSING | 2023 | 3.7 | 19.2 | 0.48 | 2025-06-25 | 5 | 4 | Physical inactivity; environmental effects; machine learning; GIS | BUILT ENVIRONMENT; ADULTS PARTICIPATION; RISK-FACTORS; URBAN FORM; NEIGHBORHOOD; ASSOCIATIONS; CLASSIFICATION; BEHAVIORS; EXPOSOME; EXERCISE | environmental effects; GIS; machine learning; Physical inactivity | United States; Disease control; Geographic information systems; Machine learning; Regression analysis; Data-driven analysis; Environmental factors; Exploratory studies; Machine learning approaches; Machine learning models; Machine-learning; Physical activity; Physical inactivity; Regression modelling; Social-economic; environmental effect; environmental factor; GIS; machine learning; performance assessment; physical activity; Association reactions | English | 2023 | 2023-12-31 | 10.1080/17538947.2023.2230944 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | A review on diverse streams of interface engineering for organic thin-film transistors | Organic thin-film transistors (OTFTs) offer a promising solution for facile, low-cost, and large-area fabrication of electronic circuitry. In the development of OTFTs, interface engineering has been essential for modulating the properties of the interfaces between the semiconductor and gate insulator and between the semiconductor and source-drain electrodes. It is worth noting that advancements in OTFTs have accompanied the dynamic subdivision of the field, with diverse technological streams focused on interface engineering. These streams include interface engineering for conventional OTFTs, memory OTFTs, sensor OTFTs, and others. As the differentiation and progress of interface engineering can, in turn, play a pivotal role in enhancing the applicability of OTFTs, it is informative to discern the diverse technological streams of multidimensional interface engineering. In this review article, we provide a critical overview of interface engineering for OTFTs, highlighting the technological diversity and varied purposes of interface engineering for different OTFT applications. We also explain the principles and mechanisms behind controlling the performance of OTFTs through interface engineering. This review will contribute to building useful insights into the design and improvement of OTFTs, as well as deepening understanding of molecular interactions and charge-carrier behaviours in these devices. This review article provides a critical overview of the diverse technological streams of interface engineering formed in the field of OTFTs. | Kwon, Jin-Hyuk; Kim, Min-Hoi; Bae, Jin-Hyuk | Hanbat Natl Univ, Res Inst Printed Elect & 3D Printing, Ind Univ Cooperat Fdn, Daejeon 34158, South Korea; Hanbat Natl Univ, Dept Creat Convergence Engn, Daejeon 34158, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | 7202469243; 38260922200; 35326180700 | mhkim8@hanbat.ac.kr;jhbae@ee.knu.ac.kr; | JOURNAL OF MATERIALS CHEMISTRY C | J MATER CHEM C | 2050-7526 | 2050-7534 | 12 | 1 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2023 | 5.7 | 19.3 | 0.3 | 2025-06-25 | 7 | 8 | FIELD-EFFECT TRANSISTORS; CHARGE-TRANSPORT; HIGH-MOBILITY; CONTACT RESISTANCE; SEMICONDUCTOR; GENERATION; 6,13-BIS(TRIISOPROPYLSILYLETHYNYL)-PENTACENE; SPECTROSCOPY; TEMPERATURE; MODULATION | Field effect transistors; Thin film circuits; Thin films; Electronic circuitry; Gate insulator; Interface engineering; Low-costs; Organic thin film transistors; Performance; Property; Source/drain electrodes; Thin-film transistor memory; Transistor sensors; Thin film transistors | English | 2023 | 2023-12-21 | 10.1039/d3tc02712k | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Acinetobacter baumannii under Acidic Conditions Induces Colistin Resistance through PmrAB Activation and Lipid A Modification | Colistin is a last-resort antimicrobial agent for treating carbapenem-resistant Acinetobacter baumannii infections. The activation of PmrAB by several environmental signals induces colistin resistance in Gram-negative bacteria. This study investigated the molecular mechanisms of colistin resistance in A. baumannii under acidic conditions using wild-type (WT) A. baumannii 17978, Delta pmrA and Delta pmrB mutants, and pmrA-complemented strains. The pmrA or pmrB deletion did not affect the growth of A. baumannii under acidic or aerobic conditions. A. baumannii under acidic (pH 5.5) and high-iron (1 mM) conditions showed 32- and 8-fold increases in the minimum inhibitory concentrations (MICs) of colistin, respectively. The Delta pmrA and Delta pmrB mutants at pH 5.5 showed a significant decrease in colistin MICs compared to the WT strain at pH 5.5. No difference in colistin MICs was observed between WT and mutant strains under high-iron conditions. The pmrCAB expression significantly increased in the WT strain at pH 5.5 compared to the WT strain at pH 7.0. The pmrC expression significantly decreased in two mutant strains at pH 5.5 compared to the WT strain at pH 5.5. The PmrA protein was expressed in the Delta pmrA strain carrying ppmrAFLAG plasmids at pH 5.5 but not at pH 7.0. Lipid A modification by the addition of phosphoethanolamine was observed in the WT strain at pH 5.5. In conclusion, this study demonstrated that A. baumannii under acidic conditions induces colistin resistance via the activation of pmrCAB operon and subsequent lipid A modification. | Ko, Seo-Yeon; Kim, Nayeong; Park, Seong-Yong; Kim, Seong-Yeop; Shin, Minsang; Lee, Je-Chul | Kyungpook Natl Univ, Sch Med, Dept Microbiol, Daegu 41944, South Korea | 57959870800; 57211500281; 57958559800; 59782772500; 7401536650; 25930392000 | sygogo97@knu.ac.kr;tbc02021@knu.ac.kr;psyseongyong@knu.ac.kr;dgsk0207@knu.ac.kr;shinms@knu.ac.kr;leejc@knu.ac.kr; | ANTIBIOTICS-BASEL | ANTIBIOTICS-BASEL | 2079-6382 | 12 | 5 | SCIE | INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY | 2023 | 4.3 | 19.3 | 1.43 | 2025-06-25 | 7 | 7 | PmrAB; Acinetobacter baumannii; lipopolysaccharide; lipid A; colistin | LIPOPOLYSACCHARIDE; VIRULENCE; SYSTEM | Acinetobacter baumannii; colistin; lipid A; lipopolysaccharide; PmrAB | bacterial protein; carbapenem; epitope; iron; lipid A; monoclonal antibody; phosphoethanolamine; acidity; Acinetobacter baumannii; Acinetobacter baumannii infection; Article; bacterial growth; bacterial strain; bacterium culture; colistin resistance; environment; matrix assisted laser desorption ionization time of flight mass spectrometry; minimum inhibitory concentration; nonhuman; operon; pH; polyacrylamide gel electrophoresis; polymerase chain reaction; protein expression; real time polymerase chain reaction; Western blotting; wild type | English | 2023 | 2023-04-26 | 10.3390/antibiotics12050813 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Analysis of Changes in Antibiotic Use Patterns in Korean Hospitals during the COVID-19 Pandemic | With the onset of the coronavirus disease 2019 (COVID-19) pandemic, changes in patient care and antibiotic use have occurred in hospitals. The data of the National Health Insurance System's claims of inpatients from all hospitals in Korea between January 2019 and December 2020 were obtained from the Health Insurance Review & Assessment Service and analyzed. The trend in the use of all antibacterial agents in both hospitals declined for the total number of COVID-19 patients at the bottom 10% and those in the top 10%. Specifically, a decreasing trend in the use of broad-spectrum antibacterial agents predominantly prescribed for community-acquired cases and narrow-spectrum beta-lactam agents were observed in both hospitals. In the aftermath of the COVID-19 pandemic, the total use of antibacterial agents has gradually decreased among patients with pneumonia and those with severe COVID-19. In contrast, its use has increased gradually among those with mild to moderate COVID-19. A decreasing trend in overall antibiotic use was observed during the COVID-19 pandemic, and an increasing trend in antibiotic use was observed in patients with mild to moderate COVID-19 in Korean hospitals. | Kim, Bongyoung; Hwang, Hyeonjun; Chae, Jungmi; Kim, Yun Seop; Kim, Dong-Sook | Hanyang Univ, Dept Internal Med, Coll Med, Seoul 04763, South Korea; Kyungpook Natl Univ, Grad Sch Data Sci, Daegu 41566, South Korea; Hlth Insurance Review & Assessment Serv, Wonju 26465, South Korea; Korea Univ, Off Res Strategy, Med Ctr, Seoul 06014, South Korea | ; Kim, Woo/AAG-1822-2019; Kim, Hyuk Soon/IQW-9348-2023; Kim, Bongyoung/H-3409-2018 | 55622077200; 57202335911; 57700552500; 57758042300; 56109775000 | sttone@hira.or.kr; | ANTIBIOTICS-BASEL | ANTIBIOTICS-BASEL | 2079-6382 | 12 | 2 | SCIE | INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY | 2023 | 4.3 | 19.3 | 0.61 | 2025-06-25 | 3 | 3 | COVID-19; antibiotics; antibiotic use; Korea | antibiotic use; antibiotics; COVID-19; Korea | antibiotic agent; antiinfective agent; beta lactam; carbapenem; metronidazole; quinoline derived antiinfective agent; adult; antibiotic resistance; Article; community acquired pneumonia; coronavirus disease 2019; extracorporeal oxygenation; health care cost; health insurance; high flow nasal cannula therapy; human; Korean (people); low income country; major clinical study; oxygen therapy; pandemic; renal replacement therapy; retrospective study; virus pneumonia | English | 2023 | 2023-02 | 10.3390/antibiotics12020198 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Assessment of Plasma Tylosin Concentrations: A Comparative Study of Immunoassay, Microbiological Assay, and Liquid Chromatography/Mass Spectrometry | Employing affordable and uncomplicated sample preparation techniques to recommend the most efficient antibacterial therapy could help reduce antibiotic-resistant bacteria. This study evaluated the suitability of immunoassays and microbiological assays as alternatives for liquid chromatography/mass spectrometry (LC/MS) in determining plasma tylosin concentrations after intramuscular administration at a dose of 20 mg/kg to both healthy and diseased pigs in clinical veterinary practice. The diseased pigs were confirmed using the target genes Actinobacillus pleuropneumoniae (apxIVA) and Pasteurella multocida (kmt1). The methods showed good linearity, precision, and accuracy. In both healthy and diseased pigs, a significant correlation was observed between LC/MS and the microbiological assay (Pearson correlation coefficient: 0.930, p < 0.001 vs. Pearson correlation coefficient: 0.950, p < 0.001) and between LC/MS and the enzyme-linked immunosorbent assay (ELISA) (Pearson correlation coefficient: 0.933; p < 0.001 vs. Pearson correlation coefficient: 0.976, p < 0.001). A strong correlation was observed between the microbiological assay and the ELISA in both healthy and diseased pigs (Pearson correlation coefficient: 0.911; p < 0.001 vs. Pearson correlation coefficient: 0.908, p < 0.001). A Bland-Altman analysis revealed good agreement between the methods, i.e., 95% of the differences were within the limits of agreement. Therefore, the microbiological assay and the ELISA, which demonstrated sufficient precision and accuracy, can be viable alternatives to LC/MS when it is unavailable. | Lee, Eon-Bee; Sayem, Syed Al Jawad; Lee, Ga-Yeong; Kim, Tae-Won; Hossain, Md Akil; Park, Seung-Chun | Kyungpook Natl Univ, Coll Vet Med, Lab Vet Pharmacokinet & Pharmacodynam, Daegu 41566, South Korea; Chungnam Natl Univ, Inst Vet Sci, Coll Vet Med, 99 Daehak Ro, Daejeon 34134, South Korea; Univ Illinois, Coll Dent, Dept Oral Biol, 801 S, Chicago, IL 60612 USA; Kyungpook Natl Univ, Cardiovasc Res Inst, Daegu 41566, South Korea | Lee, Jung Bok/HHZ-3200-2022; Hossain, Akil/AAY-7229-2020; Kim, Tae Won/GRX-7323-2022; Park, Seung-Chun/AAV-3388-2021 | 57216526135; 57221340236; 58413330500; 57208587045; 55754133800; 7501832396 | eonbee@knu.ac.kr;aljawadsayem@knu.ac.kr;ga7464@naver.com;taewonkim@cnu.ac.kr;mdakil@uic.edu;parksch@knu.ac.kr; | ANTIBIOTICS-BASEL | ANTIBIOTICS-BASEL | 2079-6382 | 12 | 6 | SCIE | INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY | 2023 | 4.3 | 19.3 | 0.41 | 2025-06-25 | 2 | 2 | tylosin; plasma concentration; liquid chromatography; mass spectrometry; microbiological assay; enzyme-linked immunosorbent assay | TANDEM MASS-SPECTROMETRY; ANTIBIOTICS; ELISA; SERUM; PHARMACOKINETICS; STAPHYLOCOCCI; ANTIBODIES | enzyme-linked immunosorbent assay; liquid chromatography/mass spectrometry; microbiological assay; plasma concentration; tylosin | antibiotic agent; nicotinamide adenine dinucleotide; tylosin; Actinobacillus pleuropneumoniae; animal experiment; antibiotic resistance; antibiotic therapy; apxIVA gene; Article; blood sampling; coinfection; comparative study; controlled study; correlation analysis; correlation coefficient; diagnostic accuracy; electrospray mass spectrometry; enzyme linked immunosorbent assay; gene; high performance liquid chromatography; immunoassay; kmt1 gene; limit of detection; limit of quantitation; liquid chromatography-mass spectrometry; microbiology; Micrococcus luteus; minimum inhibitory concentration; nonhuman; Pasteurella multocida; pig; polymerase chain reaction; veterinary medicine | English | 2023 | 2023-06 | 10.3390/antibiotics12061023 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Carbapenem Use in the Last Days of Life: A Nationwide Korean Study | The appropriate use of carbapenem is a critical concern for patient safety and public health, and is a national priority. We investigated the nationwide status of carbapenem prescription in patients within their last 14 days of life to guide judicious-use protocols from the previous study comprised of 1350 decedents. Carbapenem use was universally controlled through computerised authorisation system at all centres during the study period. Carbapenem prescribing patterns and their optimality were evaluated. A total of 1201 patients received antimicrobial agents within the last two weeks of their lives, of whom 533 (44.4%) received at least one carbapenem. The median carbapenem treatment duration was seven days. Of the 533 patients receiving carbapenems, 510 (95.7%) patients had microbiological samples drawn and 196 (36.8%) yielded carbapenem-resistant pathogens. A total of 200 (37.5%) patients were referred to infectious disease (ID) specialists. Of the 333 patients (62.5%) who did not have ID consultations, 194 (58.2%) were assessed as "not optimal", 79 (23.7%) required escalation, 100 (30.0%) required de-escalation, and 15 (4.5%) were discontinued. Notwithstanding the existing antibiotic restriction program system, carbapenems are commonly prescribed to patients in their last days of life. | Wi, Yu Mi; Kwon, Ki Tae; Jeon, Cheon-Hoo; Kim, Si-Ho; Hwang, Soyoon; Bae, Sohyun; Kim, Yoonjung; Chang, Hyun-Ha; Kim, Shin-Woo; Cheong, Hae Suk; Lee, Shinwon; Jung, Dong Sik; Sohn, Kyung Mok; Moon, Chisook; Heo, Sang Taek; Kim, Bongyoung; Lee, Mi Suk; Hur, Jian; Kim, Jieun; Yoon, Young Kyung; Korean Soc Antimicrobial Therapy | Sungkyunkwan Univ, Samsung Changwon Hosp, Dept Internal Med, Sch Med, Chang Won 51353, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med,Div Infect Dis, Daegu 41404, South Korea; Kyungpook Natl Univ Hosp, Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Div Infect Dis,Sch Med, Seoul 03181, South Korea; Pusan Natl Univ, Pusan Natl Univ Hosp, Dept Internal Med, Sch Med, Busan 50612, South Korea; Pusan Natl Univ Hosp, Med Res Inst, Busan 50612, South Korea; Dong A Univ, Dept Internal Med, Coll Med, Busan 49201, South Korea; Chungnam Natl Univ, Sch Med, Dept Internal Med, Daejeon 35015, South Korea; Inje Univ, Dept Internal Med, Div Infect Dis, Coll Med, Pusan 47392, South Korea; Jeju Natl Univ, Coll Med, Dept Internal Med, Div Infect Dis, Jeju 63241, South Korea; Hanyang Univ, Dept Internal Med, Coll Med, Seoul 04763, South Korea; Kyung Hee Univ, Kyung Hee Univ Hosp, Dept Internal Med, Div Infect Dis,Coll Med, Seoul 02447, South Korea; Yeungnam Univ, Dept Internal Med, Med Ctr, Daegu 42415, South Korea; Korea Univ, Dept Internal Med, Div Infect Dis, Coll Med, Seoul 02841, South Korea | Kim, Woo/AAG-1822-2019; Jung, Dong Sik/HOH-5826-2023; Lee, Yoojin/AAB-9799-2022; Kim, Bongyoung/H-3409-2018; Kim, Wonhee/AAA-1074-2021; Kim, Ji/J-5440-2012; Kim, Hanjin/KYP-2633-2024; Kyung, Yoon/AAS-3428-2020; Kim, Heui-Soo/ABF-3773-2021 | 23013143100; 9733850500; 57542401200; 57194288787; 57203160675; 57219699506; 57203160508; 7407521688; 57189703358; 57233155100; 24479446100; 14023089600; 16310477200; 22980995800; 9737963500; 55622077200; 55759244100; 19934047300; 51963871600; 25947937900 | yumi.wi@samsung.com;ktkwon@knu.ac.kr;cheonhoo144.jun@samsung.com;siho.kim@samsung.com;sy13111@knu.ac.kr;meditwo@knu.ac.kr;kimyj@knu.ac.kr;changhha@knu.ac.kr;ksw2kms@knu.ac.kr;philliper@naver.com;ebenezere@pusan.ac.kr;dsjung@dau.ac.kr;medone@cnuh.co.kr;csmoon@paik.ac.kr;cadevar@jejunu.ac.kr;sobakas@hanyang.ac.kr;mslee7@khu.ac.kr;sarang7529@yu.ac.kr;quidam76@hanyang.ac.kr;young7912@korea.ac.kr; | ANTIBIOTICS-BASEL | ANTIBIOTICS-BASEL | 2079-6382 | 12 | 6 | SCIE | INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY | 2023 | 4.3 | 19.3 | 0.2 | 2025-06-25 | 1 | 1 | handshake; carbapenem; antimicrobial stewardship programs | ANTIMICROBIAL USE; CONSULTATION; RESISTANCE | antimicrobial stewardship programs; carbapenem; handshake | antibiotic agent; carbapenem; aged; antimicrobial stewardship; Article; cohort analysis; consultation; drug use; female; follow up; human; male; medical record; methicillin resistant Staphylococcus aureus; multicenter study; patient safety; prescription; public health; retrospective study; treatment duration; vancomycin resistant Enterococcus | English | 2023 | 2023-06 | 10.3390/antibiotics12060964 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | CNT-functionalized electrospun fiber mat for a stretchable moisture-driven power generator | With recent demand for next-generation wearable and stretchable electronics, development of reliable power systems that can accommodate the flexibility and stretchability of devices is necessary. Recently, a moisture-driven power generator (MPG) has been considered as one of the powerful candidates for providing energy to the next-generation wearable and stretchable devices. However, so far, currently developed MPG systems do not meet the stretchability requirements. Here, we report a stretchable MPG formed by layer-by-layer coating of carbon nanotubes on a stretchable electrospun fiber mat. By adding water to the stretchable MPG, an electrical double layer is developed at the interface between the carbon nanotubes and water. Transport of protons (H3O+) in water induces the movement of electrons in the carbon nanotubes, inducing a pseudostreaming current. The MPG of 1 cm x 2 cm with 10 mu L of deionized water generates a maximum open-circuit voltage (V-OC) of 419 mV, a maximum short-circuit (I-SC) current of 1.5 mu A, and a maximum power output of 320 nW, depending on the loading of the carbon nanotubes. In addition, 0.6 M NaCl solution enhances the generated V-OC (similar to 800 mV), maximum I-SC (13 mu A), and maximum power output of 10.4 mu W by supplying additional Na+ ions to the carbon nanotube surface and reducing the resistance of the device, respectively. Furthermore, MPG can generate a V-OC of 600 mV and an I-SC of 0.7 mu A even when stretched with a strain of 60%. The MPG reported here has the potential to be used as a reliable power generator for wearable and stretchable electronic devices. | Faramarzi, Paniz; Kim, Byeunggon; You, Jae Bem; Jeong, Soo-Hwan | Kyungpook Natl Univ, Dept Hydrogen & Renewable Energy, Daegu 41566, South Korea; Kyungpook Natl Univ, KNU Inst Nanophoton Applicat KINPA, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Chem Engn, Daegu 41566, South Korea | ; Kim, Byeunggon/LXW-3860-2024; , SooHwanJeong/JOJ-6732-2023; You, Jae Bem/C-6211-2019; You, Jae/C-6211-2019 | 58089703600; 57850996900; 55619455300; 7402425359 | jb.you@knu.ac.kr;shjeong@knu.ac.kr; | JOURNAL OF MATERIALS CHEMISTRY C | J MATER CHEM C | 2050-7526 | 2050-7534 | 11 | 6 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2023 | 5.7 | 19.3 | 1.33 | 2025-06-25 | 13 | 12 | INDUCED ELECTRICITY; WATER-EVAPORATION; HUMIDITY; ENERGY; MEMBRANE; STRAIN | Carbon nanotubes; Deionized water; Electrospinning; Open circuit voltage; Sodium chloride; Wearable technology; %moisture; 'current; Electrospun fibers; Energy; Fibermat; Functionalized; Generator systems; Maximum power output; Power; Stretchable electronics; Moisture | English | 2023 | 2023-02-09 | 10.1039/d2tc04654g | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Differentiation of Escherichia fergusonii and Escherichia coli Isolated from Patients with Inflammatory Bowel Disease/Ischemic Colitis and Their Antimicrobial Susceptibility Patterns | Genotypically, 16S rRNA gene sequence analysis clearly differentiates between species. However, species delineation between Escherichia fergusonii and Escherichia coli is much more difficult and cannot be distinguished by 16S rRNA gene sequences alone. Hence, in this study, we attempted to differentiate E. fergusonii and E. coli isolated from faecal samples of disease-associated Korean individuals with inflammatory bowel disease (IBD)/ischemic colitis (IC) and test the antimicrobial susceptibility patterns of isolated strains. Phylogenetic analysis was performed using the adenylate kinase (adk) housekeeping gene from the E. coli multi locus sequence typing (MLST) scheme. Antimicrobial susceptibility and minimum inhibitory concentration (MIC) of all disease-associated strains in addition to healthy control isolates to 14 antibiotics were determined by broth microdilution-based technique. Next, 83 isolates from 11 disease-associated faecal samples were identified as E. fergusonii using 16S rRNA gene sequence analysis. Phylogenetic analysis using the adk gene from E. coli MLST scheme revealed that most of the strains (94%) were E. coli. A total of 58 resistance patterns were obtained from 83 strains of disease-associated (IBD/IC) isolates. All isolates were resistant to at least one tested antimicrobial agent, with the highest resistance against erythromycin (88.0%), ampicillin (86.7%), ciprofloxacin (73.5%), cephalothin (72.3%), gentamicin (59%), trimethoprim-sulfamethoxazole (53%), cefotaxime (49.4%), and ceftriaxone (48.2%). A total of 90.7% of isolates were extended-spectrum beta-lactamase (ESBL)-producers among the resistant strains to third-generation cephalosporins (cefotaxime or ceftriaxone). ESBL-producing E. coli isolates from patients with Crohn's disease (CD), ulcerative colitis (UC), and ischemic colitis (IC) were 92.3%, 82.4%, and 100%, respectively. In conclusion, adk-based phylogenetic analysis may be the most accurate method for distinguishing E. coli and E. fergusonii from Escherichia genus. We identified four loci in adk gene sequences which makes it easier to discriminate between E. coli and E. fergusonii. Additionally, we believe that gut colonization by multidrug-resistant ESBL-producing E. coli may play a significant role in IBD/IC pathogenesis. | Dahal, Ram Hari; Choi, Yoon-Jung; Kim, Shukho; Kim, Jungmin | Kyungpook Natl Univ, Sch Med, Dept Microbiol, Daegu 41944, South Korea | Dahal, Ram Hari/H-8673-2016; Kim, Shukho/AGG-1087-2022 | 57110097800; 57220082311; 24341187900; 57211297681 | minkim@knu.ac.kr; | ANTIBIOTICS-BASEL | ANTIBIOTICS-BASEL | 2079-6382 | 12 | 1 | SCIE | INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY | 2023 | 4.3 | 19.3 | 1.23 | 2025-06-25 | 6 | 6 | gut microbiome; gut colonization; inflammatory bowel disease (IBD); ischemic colitis (IC); antimicrobial resistance (AMR); multidrug resistance (MDR); ESBL-producing E; coli | MULTIPLE SEQUENCE ALIGNMENT; DISEASE; ENTEROBACTERIACEAE; RESISTANCE; PATHOGENESIS; MICROBIOTA; GUT | antimicrobial resistance (AMR); ESBL-producing E. coli; gut colonization; gut microbiome; inflammatory bowel disease (IBD); ischemic colitis (IC); multidrug resistance (MDR) | adenylate kinase; amikacin; amoxicillin plus clavulanic acid; bacterial DNA; carbapenemase; cefalotin; cefotaxime; ceftriaxone; cephalosporin derivative; chloramphenicol; ciprofloxacin; colistin; cotrimoxazole; erythromycin; extended spectrum beta lactamase; gentamicin; RNA 16S; tetracycline; antibiotic sensitivity; Article; bootstrapping; broth dilution; Crohn disease; Escherichia coli; Escherichia fergusonii; feces analysis; feces microflora; gene amplification; gene sequence; genotype; human; inflammatory bowel disease; ischemic colitis; minimum inhibitory concentration; multilocus sequence typing; nucleotide sequence; phylogeny; ulcerative colitis | English | 2023 | 2023-01 | 10.3390/antibiotics12010154 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Engineered current path of vertical organic phototransistors for smart optoelectronic applications | As the demands for smart optoelectronics, including photosensor and photomemory, are increasing, multifunctional organic field-effect transistors have been considered as useful candidates for these complex systems. In particular, the vertical-type organic phototransistor (VOPT) is considered more promising for practical optoelectronic applications than the typical lateral-structured devices in terms of electro-optical characteristics and integration density. However, the on/off current ratio and photosensitivity of VOPTs are inherently constrained because of the presence of leakage current that flows along the structurally uncontrollable charge paths. Although considerable effort has been exerted to reduce the leakage current in VOPTs, developing VOPT with a high on/off ratio and photosensitivity remains challenging for practical applications of photosensor and photomemory. In this paper, we proposed a promising strategy for precisely engineering the current path of VOPTs. A charge blocking layer (CBL) is introduced at the interface between the source electrode and organic semiconductor. Its geometrical structure is simply optimized using a self-alignment process to effectively limit the paths of the leakage current. The developed VOPT with CBL presents a highly enhanced on/off current ratio and photosensitivity compared with the typical device. Moreover, our device demonstrates high potential as photodetector and photomemory for smart optoelectronic systems. This novel concept of realizing VOPTs to function as superior photosensor and photomemory can potentially become a fundamental platform for the advancement of next-generation optoelectronics in Internet-of-Things systems. | An, Hye-Min; Jang, Hyowon; Kim, Hyeok; Lee, Sin-Doo; Lee, Sin-Hyung; Park, Hea-Lim | Seoul Natl Univ Sci & Technol, Dept Mat Sci & Engn, Seoul 01811, South Korea; Univ Seoul, Ctr Smart Sensor Syst Seoul CS4, Sch Elect & Comp Engn, 163 Seoulsiripdaero, Seoul 02504, South Korea; Seoul Natl Univ, Sch Elect Engn, Seoul 151600, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, 80 Daehak Ro, Daegu 702701, South Korea | ; Lee, Sin-Hyung/ABD-6425-2022 | 58670706600; 57640445300; 57191718658; 34974364800; 57226880204; 55735654600 | sinhlee@knu.ac.kr;parkhl21@seoultech.ac.kr; | JOURNAL OF MATERIALS CHEMISTRY C | J MATER CHEM C | 2050-7526 | 2050-7534 | 11 | 42 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2023 | 5.7 | 19.3 | 1.44 | 2025-06-25 | 12 | 13 | FIELD-EFFECT TRANSISTORS; ULTRAHIGH RESPONSIVITY; THIN-FILMS; PHOTODETECTOR | Leakage currents; Light sensitive materials; Optical sensors; Optoelectronic devices; Organic field effect transistors; Phototransistors; Blocking layers; Current paths; Electro-optical characteristics; ON/OFF current ratio; On/off-current ratios; Optoelectronic applications; Organic field-effect transistors; Organic phototransistors; Photosensor; Vertical-type; Photosensitivity | English | 2023 | 2023-11-02 | 10.1039/d3tc02571c | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Evaluating Biofilm Inhibitory Potential in Fish Pathogen, Aeromonas hydrophila by Agricultural Waste Extracts and Assessment of Aerolysin Inhibitors Using In Silico Approach | Aeromonas hydrophila, an opportunistic bacteria, causes several devastating diseases in humans and animals, particularly aquatic species. Antibiotics have been constrained by the rise of antibiotic resistance caused by drug overuse. Therefore, new strategies are required to prevent appropriate antibiotic inability from antibiotic-resistant strains. Aerolysin is essential for A. hydrophila pathogenesis and has been proposed as a potential target for inventing drugs with anti-virulence properties. It is a unique method of disease prevention in fish to block the quorum-sensing mechanism of A. hydrophila. In SEM analysis, the crude solvent extracts of both groundnut shells and black gram pods exhibited a reduction of aerolysin formation and biofilm matrix formation by blocking the QS in A. hydrophila. Morphological changes were identified in the extracts treated bacterial cells. Furthermore, in previous studies, 34 ligands were identified with potential antibacterial metabolites from agricultural wastes, groundnut shells, and black gram pods using a literature survey. Twelve potent metabolites showed interactions between aerolysin and metabolites during molecular docking analysis, in that H-Pyran-4-one-2,3 dihydro-3,5 dihydroxy-6-methyl (-5.3 kcal/mol) and 2-Hexyldecanoic acid (-5.2 kcal/mol) showed promising results with potential hydrogen bond interactions with aerolysin. These metabolites showed a better binding affinity with aerolysin for 100 ns in molecular simulation dynamics. These findings point to a novel strategy for developing drugs using metabolites from agricultural wastes that may be feasible pharmacological solutions for treating A. hydrophila infections for the betterment of aquaculture. | Arumugam, Manikandan; Manikandan, Dinesh Babu; Marimuthu, Sathish Kumar; Muthusamy, Govarthanan; Kari, Zulhisyam Abdul; Tellez-Isaias, Guillermo; Ramasamy, Thirumurugan | Bharathidasan Univ, Sch Life Sci, Dept Anim Sci, Lab Aquabiot Nanosci, Tiruchirappalli 620024, India; Anna Univ, Bharathidasan Inst Technol, Univ Coll Engn, Dept Pharmaceut Technol, BIT Campus, Tiruchirappalli 620024, India; Kyungpook Natl Univ, Dept Environm Engn, Daegu 41566, South Korea; Univ Malaysia Kelantan, Fac Agrobased Ind, Dept Agr Sci, Jeli Campus, Jeli 17600, Malaysia; Univ Malaysia Kelantan, Fac Agrobased Ind, Adv Livestock & Aquaculture Res Grp, Jeli Campus, Jeli 17600, Malaysia; Univ Arkansas, Dept Poultry Sci, Fayetteville, AR 72701 USA | Abdul Kari, Zulhisyam/A-2475-2014; Ramasamy, Thirumurugan/JCE-4858-2023; Marimuthu, Sathish/AAQ-7230-2021; Govarthanan, Muthusamy/C-1491-2014; Abdul Kari, Dr Zulhisyam/ITT-1080-2023; Muthusamy, Govarthanan/C-1491-2014 | 57219547966; 57202944985; 57197831432; 54881927600; 37103229800; 40861825800; 6701646486 | ramthiru72@bdu.ac.in; | ANTIBIOTICS-BASEL | ANTIBIOTICS-BASEL | 2079-6382 | 12 | 5 | SCIE | INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY | 2023 | 4.3 | 19.3 | 1.23 | 2025-06-25 | 6 | 6 | aerolysin; agri-waste; antimicrobial metabolites; molecular docking and dynamics; quorum sensing | QUORUM-SENSING SYSTEMS; ANTIMICROBIAL ACTIVITIES; ANTIBIOTIC-RESISTANCE; MOLECULAR DOCKING; MEDICINAL-PLANTS; VIRULENCE; BINDING; WATER; ANTIOXIDANT; REDUCTION | aerolysin; agri-waste; antimicrobial metabolites; molecular docking and dynamics; quorum sensing | aerolysin; antibiotic agent; petroleum ether; streptomycin; Aeromonas; Aeromonas hydrophila; agricultural waste; amino acid sequence; Anacardiaceae; antibiotic resistance; Apiaceae; aquaculture; aquatic species; Article; bacterial cell; biofilm; biofilm matrix; biomass; Burseraceae; Cupressaceae; drug overdose; Euphorbiaceae; Fabaceae; hydrogen bond; minimum inhibitory concentration; molecular docking; molecular dynamics; nonhuman; phylogeny; quorum sensing; scanning electron microscopy; simulation | English | 2023 | 2023-05-11 | 10.3390/antibiotics12050891 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Initiatives for biodiversity conservation and utilization in crop protection: A strategy for sustainable crop production | A major challenge for mankind is how to increase agricultural productivity while preserving and increasing biodiversity. The competition between humans, weeds, pests, and diseases has led to significant losses in agricultural products, highlighting the ecological and financial necessity of making efficient and sustainable use of limited resources such as land, water, and soil. Because biodiversity offers a variety of ecosystem services that can be used to boost agricultural production and encourage sustainability, it is crucial to use it for crop protection. Biodiversity forms the very foundation for the development of effective biological management techniques utilizing natural enemies to regulate the populations of undesirable organisms, thereby improving crop health and yield. However, inadequate management and protection of biodiversity have led to the fundamental functions that ecosystems provide to humans being threatened. To effectively address and prevent the challenges posed by biodiversity, plant protection products must be used safely and properly by farmers and land managers. This review explores how biodiversity can be used to manage pests and diseases, including soil fertility and plant resilience, using various cutting-edge techniques, including biotechnology and organic improvement. It also examines crop losses caused by insect pests, providing valuable insights for crop protection. | Yadav, Shubh Pravat Singh; Adhikari, Riya; Bhatta, Dibya; Poudel, Anju; Subedi, Subash; Shrestha, Suraj; Shrestha, Jiban | Purbanchal Univ, GP Koirala Coll Agr & Res Ctr, Gothgaun, Morang, Nepal; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Tennessee State Univ, Otis L Floyd Nursery Res Ctr, Dept Agr & Environm Sci, 472 Cadillac Lane, Mcminnville, TN 37110 USA; Nepal Agr Res Council, Oilseed Res Program, Nawalpur, Sarlahi, Nepal; Agr & Forestry Univ, Rampur, Chitwan, Nepal; Nepal Agr Res Council, Natl Plant Breeding & Genet Res Ctr, Khumaltar, Lalitpur, Nepal | Shrestha, Jiban/AAD-1778-2020; Yadav, Shubh Pravat/GNH-2091-2022; Poudel, Anju/HLG-3959-2023; Shrestha, Suraj/JPL-6413-2023 | 57984455200; 58615089100; 59325593600; 58059925700; 57221762732; 58073564600; 57221769055 | sushantpy8500@gmail.com;riyaadhikari280@gmail.com;divine@knu.ac.kr;anjupoudel65@gmail.com;subedi.subash1@gmail.com;suraz.stha07@gmail.com;jibshrestha@gmail.com; | BIODIVERSITY AND CONSERVATION | BIODIVERS CONSERV | 0960-3115 | 1572-9710 | 32 | 14 | SCIE | BIODIVERSITY CONSERVATION;ECOLOGY;ENVIRONMENTAL SCIENCES | 2023 | 3 | 19.3 | 0.92 | 2025-06-25 | 7 | 14 | Biological diversity; Ecofriendly approach; Conservation; Indigenous; Sustainable crop production | ORGANIC AGRICULTURE; ECOSYSTEM SERVICES; FOOD-PRODUCTION; DIVERSITY; BIOPESTICIDES; LOSSES | Biological diversity; Conservation; Ecofriendly approach; Indigenous; Sustainable crop production | biodiversity; biotechnology; crop production; soil fertility; sustainable development | English | 2023 | 2023-12 | 10.1007/s10531-023-02718-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | NIR-sensing ambipolar organic phototransistors with conjugated terpolymer layers based on diketopyrrolopyrrole-benzothiadiazole-naphthalenediimide comonomer units | Here we report ambipolar organic phototransistors (OPTRs), which can be operated in both p-channel and n-channel modes, with sensing channel layers of a conjugated terpolymer, poly[4-(5-(4-(5-(6-methoxy-7 methyl-5-(octyloxy)benzo[c][1,2,5]thiadiazol-4-yl)thiophen-2-yl)-2-(2-methyldodecyl)-5-(2-octyldodecyl) 3,6-dioxo-2,3,5,6-tetrahydropyrrolo[3,4-c]pyrrol-1-yl)thiophen-2-yl)-9-methyl-2,7-bis(2-octyldodecyl)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone] (PDPP-8OBT-NDI) that was synthesized by Stille coupling reaction of three comonomers. The PDPP-8OBT-NDI films showed a broadband optical absorption up to 1100 nm and good thermal stability. The organic field-effect transistors (OFETs) with PDPP-8OBT-NDI layers exhibited quite well-balanced ambipolar characteristics at the gate and drain voltage range of +/- 10 V in the dark, as supported by the drain current ratio (DCR) of 1.09-1.2. Upon illumination with NIR light (wavelength (lambda) = 810 and 905 nm), the drain current of the devices was sensitively changed with the incident NIR light in the presence of a noticeable threshold voltage shift, even though the ambipolar characteristics of the OPTRs were marginally increased up to DCR = 1.27. The photosensitivity of the OPTRs with 80 nm-thick PDPP-8OBT-NDI layers reached ca. 665% (p-channel) and 622% (n-channel) at lambda = 810 nm, while slightly lower photosensitivity of ca. 413% (p-channel) and 373% (n-channel) was measured at lambda = 905 nm. The flexible OPTRs with 80 nm-thick PDPP-8OBT-NDI layers delivered good ambipolar characteristics upon continuous NIR light illumination and reproducible photocurrent responses upon optical on/off modulations of NIR light (lambda = 905 nm). | Cho, Yeonhwa; Kim, Taehoon; Lee, Woongki; Kim, Hwajeong; Kim, Youngkyoo | Kyungpook Natl Univ, Dept Chem Engn, Organ Nanoelecron Lab, Daegu 41566, South Korea; Kyungpook Natl Univ, KNU Inst Nanophoton Applicat KINPA, Dept Chem Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Environm Sci &Technol, Prior Res Ctr, Daegu 41566, South Korea | 57542729800; 57218650958; 59041346100; 15520531700; 10340424400 | ykimm@knu.ac.kr; | JOURNAL OF MATERIALS CHEMISTRY C | J MATER CHEM C | 2050-7526 | 2050-7534 | 11 | 8 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2023 | 5.7 | 19.3 | 1.11 | 2025-06-25 | 10 | 10 | FIELD-EFFECT TRANSISTORS; CHANNEL; PERFORMANCE; TRANSPORT; POLYMERS; ACCEPTOR; GATE; BAND | Drain current; Incident light; Infrared devices; Light absorption; Light sensitive materials; Organic field effect transistors; Phototransistors; Threshold voltage; Ambipolar; Ambipolar characteristics; Benzothiadiazoles; Comonomer units; Current ratios; Diketopyrrolopyrroles; N-channel; Organic phototransistors; P channels; Sensing channels; Photosensitivity | English | 2023 | 2023-02-23 | 10.1039/d2tc04889b | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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