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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | LncRNA BRE-AS1 regulates the JAK2/STAT3-mediated inflammatory activation via the miR-30b-5p/SOC3 axis in THP-1 cells | Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators in numerous biological processes, including macrophage-mediated inflammatory responses, which play a critical role in the progress of diverse diseases. This study focuses on the regulatory function of lncRNA brain and reproductive organ-expressed protein (BRE) antisense RNA 1 (BRE-AS1) in modulating the inflammatory activation of monocytes/macrophages. Employing the THP-1 cell line as a model, we demonstrate that lipopolysaccharide (LPS) treatment significantly upregulates BRE-AS1 expression. Notably, specific knockdown of BRE-AS1 via siRNA transfection enhances LPS-induced expression of interleukin (IL)-6 and IL-1 beta, while not affecting tumor necrosis factor (TNF)-alpha levels. This selective augmentation of pro-inflammatory cytokine production coincides with increased phosphorylation of Janus kinase (JAK)2 and signal transducer and activator of transcription (STAT)3. Furthermore, BRE-AS1 suppression results in the downregulation of suppressor of cytokine signaling (SOCS)3, an established inhibitor of the JAK2/STAT3 pathway. Bioinformatics analysis identified binding sites for miR-30b-5p on both BRE-AS1 and SOCS3 mRNA. Intervention with a miR-30b-5p inhibitor and a synthetic RNA fragment that represents the miR-30b-5p binding site on BRE-AS1 attenuates the pro-inflammatory effects of BRE-AS1 knockdown. Conversely, a miR-30b-5p mimic replicated the BRE-AS1 attenuation outcomes. Our findings elucidate the role of lncRNA BRE-AS1 in modulating inflammatory activation in THP-1 cells via the miR-30b-5p/SOCS3/JAK2/STAT3 signaling pathway, proposing that manipulation of macrophage BRE-AS1 activity may offer a novel therapeutic avenue in diseases characterized by macrophage-driven pathogenesis. | Shin, Jae-Joon; Suk, Kyoungho; Lee, Won-Ha | Kyungpook Natl Univ, Sch Life Sci, BK21 Plus KNU Creat Biores Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Dept Pharmacol, BK21 Plus KNU Biomed Convergence Program,Sch Med, Daegu 41944, South Korea | 58662949200; 7005114595; 57205609794 | whl@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0.41 | 2025-05-07 | 1 | 1 | LncRNA; miRNA; SOCS3; JAK2; STAT3 | LIPOPOLYSACCHARIDE; MECHANISMS; STAT3; BINDS; RNAS | JAK2; LncRNA; miRNA; SOCS3; STAT3 | Gene Expression Regulation; Humans; Inflammation; Janus Kinase 2; Lipopolysaccharides; Macrophages; MicroRNAs; RNA, Long Noncoding; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; THP-1 Cells; JAK2 protein, human; Janus kinase 2; lipopolysaccharide; long untranslated RNA; microRNA; MIRN30b microRNA, human; SOCS3 protein, human; STAT3 protein; STAT3 protein, human; suppressor of cytokine signaling; suppressor of cytokine signaling 3; gene expression regulation; genetics; human; inflammation; macrophage; metabolism; pathology; signal transduction; THP-1 cell line | English | 2024 | 2024-10-28 | 10.1038/s41598-024-77265-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Long-term air pollution exposure is associated with higher incidence of ST-elevation myocardial infarction and in-hospital cardiogenic shock | Previous studies have reported the association between myocardial infarction (MI) and air pollution (AP). However, limited information is available regarding the long-term effects of AP on the relative incidence rates of ST-elevation MI (STEMI) and Non-ST-elevation MI (NSTEMI). We investigated the association between long-term exposure to AP and the incidence of STEMI. Between January 2006 and December 2015, a total of 45,619 eligible patients with Acute Myocardial Infarction (AMI) were enrolled in the Korea Acute MI Registry (KAMIR) and KAMIR-National Institutes of Health. Mixed-effect regression models were used to examine the association between the annual average ambient AP before MI onset and the incidence of STEMI, and to evaluate the association of AP with the incidence of in-hospital cardiogenic shock. After mixed-effect regression model analysis, particulate matter (PM) 10 µm or less in diameter (PM10) was associated with increased incidence of STEMI compared with NSTEMI (odds ratio [OR] 1.009, 95% Confidence Interval [CI] 1.002–1.016; p = 0.012). For in-hospital cardiogenic shock complication, PM10 and SO2 were associated with increased risk, PM10 (OR 1.033, 95% CI 1.018–1.050; p < 0.001), SO2 (OR 1.104, 95% CI 1.006–1.212; p = 0.037), respectively. Policy-level strategies and clinical efforts to reduce AP exposure are necessary to prevent the incidence of STEMI and severe cardiovascular complications. © The Author(s) 2024. | Cha, Jinah; Choi, Se Yeon; Rha, Seung-Woon; Choi, Byoung Geol; Byun, Jae Kyeong; Hyun, Sujin; Lee, Min Woo; Kang, Jaeho; Chu, Wonsang; Park, Eun Jin; Kang, Dong Oh; Choi, Cheol Ung; Kim, Suhng Wook; Jeong, Myung Ho; Park, Soohyung; Rha, Seung-Woon; Ahn, Tae Hoon; Yoon, Junghan; Kim, Hyo-Soo; Seung, Ki-Bae; Gwon, Hyeon-Cheol; Chae, Shung Chull; Kim, Chong-Jin; Cha, Kwang Soo; Lee, Jung-Hee; Chae, Jei Keon; Joo, Seung-Jae; Yoon, Chang-Hwan; Hur, Seung-Ho; Seong, In-Whan; Hwang, Kyung-Kuk; Kim, Doo-Il; Oh, Seok Kyu; Hwang, Jin-Yong | BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, 02841, South Korea, Department of Cardiology, Cardiovascular Center, Guro Hospital, Korea University College of Medicine, Seoul, 08308, South Korea; Cardiovascular Research Institution, Korea University College of Medicine, Seoul, 02841, South Korea; BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, 02841, South Korea; Cardiovascular Research Institution, Korea University College of Medicine, Seoul, 02841, South Korea; Cardiovascular Research Institution, Korea University College of Medicine, Seoul, 02841, South Korea; Transdisciplinary Major in Learning Health Systems, Department of Healthcare Sciences, Graduate School, Seoul, 02841, South Korea; Research Institute of Health Science, Korea University, Seoul, 02841, South Korea; Department of Cardiology, Cardiovascular Center, Guro Hospital, Korea University College of Medicine, Seoul, 08308, South Korea; Department of Cardiology, Cardiovascular Center, Guro Hospital, Korea University College of Medicine, Seoul, 08308, South Korea; Department of Cardiology, Cardiovascular Center, Guro Hospital, Korea University College of Medicine, Seoul, 08308, South Korea; Department of Cardiology, Cardiovascular Center, Guro Hospital, Korea University College of Medicine, Seoul, 08308, South Korea; Department of Cardiology, Cardiovascular Center, Guro Hospital, Korea University College of Medicine, Seoul, 08308, South Korea; School of Health and Environmental Science, College of Health Sciences, Korea University, Seoul, 02841, South Korea; Department of Cardiology, Cardiovascular Center, Chonnam National University Hospital, Gwangju, 61469, South Korea, Chonnam National University Hospital, Gwangju, South Korea; Department of Cardiology, Cardiovascular Center, Guro Hospital, Korea University College of Medicine, Seoul, 08308, South Korea; Korea University Guro Hospital, Seoul, South Korea; Gachon University Gil Medical Center, Incheon, South Korea; Wonju Severance Christian Hospital, Wonju, South Korea; Seoul National University Hospital, Seoul, South Korea; Seoul St. Mary’s Hospital, Seoul, South Korea; Samsung Medical Center, Seoul, South Korea; Kyungpook National University Hospital, Daegu, South Korea; Kyung Hee University Hospital at Gangdong, Seoul, South Korea; Pusan National University Hospital, Busan, South Korea; Yeungnam University Medical Center, Daegu, South Korea; Jeonbuk National University Hospital, Jeonju, South Korea; Jeju National University Hospital, Jeju, South Korea; Seoul National University Bundang Hospital, Seongnam, South Korea; Keimyung University Dongsan Medical Center, Daegu, South Korea; Chungnam National University Hospital, Daejeon, South Korea; Chungbuk National University Hospital, Cheongju, South Korea; Inje University Haeundae Paik Hospital, Busan, South Korea; Wonkwang University Hospital, Iksan, South Korea; Gyeongsang National University Hospital, Jinju, South Korea | 57216301506; 57199723581; 8569030400; 57192178767; 56658301600; 58481810100; 59277862300; 58489270400; 58489470300; 57200596461; 57209310106; 15046409800; 7601579891; 56485157500; 57719909900; 59968335100; 57222278496; 35760728900; 33567809200; 7003964208; 6603262426; 7101962036; 35229511500; 7102837700; 55969086000; 26029709000; 9236504200; 7202882965; 34570274500; 35254371300; 58842870300; 8635545900; 24734336000; 55892914700 | swrha617@yahoo.co.kr;shp503@naver.com; | Scientific Reports | SCI REP-UK | 2045-2322 | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 1.23 | 2025-05-07 | 3 | Air Pollution; Humans; Incidence; Myocardial Infarction; Non-ST Elevated Myocardial Infarction; Particulate Matter; Registries; Risk Factors; Shock, Cardiogenic; ST Elevation Myocardial Infarction; United States; air pollution; cardiogenic shock; complication; heart infarction; human; incidence; non ST segment elevation myocardial infarction; particulate matter; register; risk factor; ST segment elevation myocardial infarction; United States | English | Final | 2024 | 10.1038/s41598-024-55682-6 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Metabolomics study to reveal cognitive improvement with treatment of Scrophularia buergeriana | Population aging around the world is rapidly progressing; as a result, cognitive decline developing into dementia is becoming a social problem. There is no drug that can cure dementia, and though drugs that alleviate the symptoms of dementia have been developed, they also have side effects. Therefore, we conducted a study on improving cognitive function using natural products that have secured safety. We confirmed the effect of an extract of Scrophularia buergeriana on scopolamine-induced cognitive impairment through mouse behavioral experiments, and we observed metabolic changes in the cortex and hippocampus via brain tissue dissection after the behavioral experiment. Mitigating effects of S. buergeriana on cognitive impairment caused by scopolamine were observed in passive avoidance and Morris water maze tests. A metabolic analysis revealed biomarkers related to the alleviating effect of cognitive impairment. Niacinamide, tyrosine, uridine, and valine in the cortex and GABA, choline, creatine, formate, fumarate, hypoxanthine, leucine, myo-inositol, pyroglutamate, and taurine in the hippocampus were identified as biomarker candidates for recovering cognitive impairment. In addition to behavioral experiments, this metabolomics study using specific regions of the brain may be helpful in understanding the effects of cognitive improvement. | Yoon, Dahye; Oh, Seon Min; Na, Hyeon Seon; Choi, Bo-Ram; Kim, Kwan-Woo; Lee, Young-Seob; Lee, Dong-Ryung; Lee, Dae Young | Natl Inst Hort & Herbal Sci, Dept Herbal Crop Res, RDA, Eumseong 27709, South Korea; KRIBB, Nat Prod Res Ctr, Ochang 28116, South Korea; KRIBB, Nat Prod Cent Bank, Ochang 28116, South Korea; NUON Co Ltd, Seongnam 13201, South Korea; Kyungpook Natl Univ, Sch Life Sci, FOUR KNU Creat Biores Grp BK21, Daegu 41566, South Korea | Lee, Dae Young/ADO-9686-2022 | 55855383700; 58404032700; 57212602549; 57194340567; 57188988057; 37030914700; 56449546600; 57750904900 | dylee80@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0 | 2025-05-07 | 1 | 1 | ALZHEIMERS-DISEASE; INCREASES; ACID | Animals; Behavior, Animal; Biomarkers; Cognition; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Male; Maze Learning; Metabolome; Metabolomics; Mice; Plant Extracts; Scopolamine; Scrophularia; biological marker; plant extract; scopolamine; animal; animal behavior; chemistry; cognition; cognitive defect; disease model; drug effect; drug therapy; hippocampus; male; maze test; metabolism; metabolome; metabolomics; mouse; procedures; Scrophularia | English | 2024 | 2024-07-23 | 10.1038/s41598-024-66371-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Microcurrent wave alleviates mouse intracranial arterial dolichoectasia development | Intracranial arterial dolichoectasia (IADE) is associated with the interaction of hypertension and inflammation, and microcurrent can be effective in hypertension. Therefore, this study aimed to investigate the therapeutic effect of microcurrent electrical stimulation in a mouse IADE model. This study randomly categorized 20 mice into five groups: group 1-C (healthy control), group 2-D (IADE model), group 3-M + D (microcurrent administration before nephrectomy and until brain surgery), group 4-D + M (microcurrent administration for 4 weeks following brain surgery), and group 5-M (microcurrent administration for 4 weeks). Cerebral artery diameter and thickness and cerebral arterial wall extracellular matrix components were assessed. Among the five groups, group 2-D showed significantly higher cerebral arterial wall diameter (117.79 +/- 17.05 mu m) and proportion of collagen (42.46 +/- 14.12%) and significantly lower arterial wall thickness (9.31 +/- 2.26 mu m) and proportion of smooth muscle cell (SMC) and elastin in the cerebral arterial wall (SMC: 38.05 +/- 10.32%, elastin: 11.11 +/- 6.97%). Additionally, group 4-D + M exhibited a non-significantly lower diameter (100.28 +/- 25.99 mu m) and higher thickness (12.82 +/- 5.17 mu m). Group 5-M demonstrated no evidence of toxicity in the liver and brain. The pilot study revealed that microcurrent is effective in preventing IADE development, although these beneficial effects warrant further investigation. | Lee, Jae Hee; Vu, Huy Duc; Park, Min Hee; Huynh, Phuong Tu; Youn, Sung Won; Kwon, Dong Rak | Daegu Catholic Univ, Sch Med, Dept Rehabil Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Radiol, Daegu, South Korea | Youn, Sung-Won/AAH-1723-2020 | 58865079900; 57280380200; 58961109700; 56829091800; 57206373939; 13205407500 | ysw24neurorad@knu.ac.kr;coolkwon@cu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0.41 | 2025-05-07 | 1 | 1 | MATRIX METALLOPROTEINASE-8; HYPERTENSION; THERAPY; ANEURYSM; PATHOGENESIS; INFLAMMATION; MANAGEMENT; EFFICACY; INFANTS; RUPTURE | Animals; Brain; Cerebral Arteries; Elastin; Hypertension; Mice; Pilot Projects; elastin; animal; brain; brain artery; hypertension; mouse; pilot study | English | 2024 | 2024-03-29 | 10.1038/s41598-024-58333-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Microneedle patch casting using a micromachined carbon master for enhanced drug delivery | For successful treatment of diseases, sufficient therapeutics must be provided to the body. Microneedle applications in therapeutic delivery and analytics sampling are restricted because of various issues, including smaller area for drug loading and analytics sampling. To achieve sufficient drug loading and analytics sampling and improve drug penetration while maintaining painless administration, patch-type microneedle arrays were designed and fabricated using polymer casting from a conical cavity mold. Microcavities were formed on a carbon plate via micromechanical machining. A porous polymer layer was coated on a microneedle patch (MNP). The pores of the porous polymer layer provided space and channels for drug delivery. A pH-sensitive polymer layer was employed to cap the porous polymer layer, which prevented drug leakage during storage and provided a stimulus drug release in response to body pH conditions. The drug can be delivered through holes connected to both sides of the patch. The drug release of the MNP was investigated in vitro and in vivo and showed conceptual proof that these MNs have the potential to enhance treatment protocols for various diseases with the flexibility of coating and therapeutic materials and offer significant scope for further variations and advancement. | Choi, Hye Jin; Ullah, Asad; Jang, Mi Jin; Lee, Ui Seok; Shin, Min Chul; An, Sang Hyun; Kim, Dongseon; Kim, Bo Hyun; Kim, Gyu Man | Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Univ Engn & Technol, Dept Mech Engn, Mardan 23200, Khyber Pakhtunk, Pakistan; Daegu Gyeongbuk Med Innovat Fdn, Preclin Res Ctr, Daegu 41061, South Korea; Soongsil Univ, Grad Sch, Dept Mech Engn, 369 Sangdo Ro, Seoul 06978, South Korea; Soongsil Univ, Sch Mech Engn, Seoul 06978, South Korea | Kim, Bo-Hyun/HHN-3181-2022; Shin, Min/AAU-6206-2021; Kim, Bo Hyun/GPT-0710-2022 | 57203969417; 57226132377; 57222997201; 57221131563; 57226714930; 57102583100; 58291623700; 57208727671; 55664733000 | bhkim@ssu.ac.kr;gyuman.kim@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0 | 2025-05-07 | 0 | 0 | Microneedles; Porous polymer coating; Stimulus release; Micromechanical machining | POLYMER MICRONEEDLES; PH | Micromechanical machining; Microneedles; Porous polymer coating; Stimulus release | Animals; Carbon; Drug Delivery Systems; Drug Liberation; Hydrogen-Ion Concentration; Mice; Microinjections; Needles; Polymers; Porosity; carbon; polymer; animal; chemistry; devices; drug delivery system; drug release; microinjection; mouse; needle; pH; porosity; procedures | English | 2024 | 2024-08-20 | 10.1038/s41598-024-70393-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Mitigating salinity stress on tomato growth, water regime, gas exchange, and yield with the application of QuitoMax | This study assessed the intensity of salt stress in the two tomato varieties by measuring variables associated with the water regime, chlorophyll content, normalized difference vegetation index, gas exchange, and yield. The cultivars Amalia and Claudia, which represent tolerance and susceptibility to salinity, were evaluated. Three treatments were established in plastic pots, using a completely randomized design: T1, saline soil (ECse = 6.9 dS m-1 without QuitoMax application); T2, nonsaline soil (ECse = 0.95 dS m -1 with QuitoMax application); and T3, saline soil (ECse = 6.9 dS m-1) with QuitoMax application. The QuitoMax was applied at a rate of 300 mg L-1, during the flowering phenophase. QuitoMax caused an increase in the variables evaluated in both varieties (tolerant and susceptible) of tomato, with a lower contribution of QuitoMax to the variables related to water regime and the greatest contributions to chlorophyll content and photosynthetic activity. QuitoMax contributed positively to all variables and was superior to stress intensity for most of the variables evaluated in the tolerant variety (Amalia), except for stem thickness and the number of flowers per bunch. In the susceptible variety (Claudia), the five variables of stress intensity exceeded the contribution of QuitoMax, with the strongest effects on osmotic potential, fruit mass, and yield per plant. The present work demonstrates the feasibility of using this biostimulant to increase the tolerance of tolerant varieties and maintain tolerance in tomato varieties susceptible to salinity, reducing the intensity of saline stress and increasing plant performance under salinity conditions. | Argentel-Martinez, Leandris; Penuelas-Rubio, Ofelda; Amador, Carlos avila; Steiner, Fabio; Aguilera, Jorge Gonzalez; Shin, Jae-Ho; Zuffo, Alan Mario; Ratke, Rafael Felippe; Teodoro, Paulo Eduardo; Azizoglu, Ugur | Tecnol Nacl Mexico, Inst Tecnol Valle Yaqui, Bacum 85260, Sonora, Mexico; Univ Estadual Mato Grosso Do Sul UEMS, Dept Agron, BR-79540000 Cassilandia, MS, Brazil; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, Daegu 41566, South Korea; Univ Estadual Maranhao, Agron Dept, Campus Balsas, BR-65800000 Balsas, MA, Brazil; Fed Univ Mato Grosso Do Sul UFMS, Agron Dept, BR-79650000 Chapadao, MS, Brazil; Kayseri Univ, Safiye Cikrikcioglu Vocat Coll, Dept Crop & Anim Prod, Kayseri, Turkiye; Erciyes Univ, Genome & Stem Cell Res Ctr, Kayseri, Turkiye | ; Argentel, Leandris/AAQ-7171-2021; Ratke, Rafael Felippe/F-7702-2015; Zuffo, Alan/AAY-6828-2020; Steiner, Fábio/AAH-5522-2019; Azizoglu, Ugur/ABC-7831-2020; Ratke, Rafael/F-7702-2015; Peñuelas-Rubio, Ofelda/GQB-5410-2022; shin, Jaeho/K-6792-2013; Gonzalez Aguilera, Jorge/G-9077-2014; Teodoro, Paulo/IUM-1884-2023; Steiner, Fabio/E-8171-2016; Aguilera, Jorge/M-6216-2019 | 57202038750; 57194395312; 59495610900; 37049309200; 49860933500; 57224125922; 54950089300; 57227000000; 55992461900; 52363128100 | azizoglu@kayseri.edu.tr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0.41 | 2025-05-07 | 1 | 1 | Contribution; Salinity; Amalia; Claudia; Chitosan; NaCl | FOLIAR APPLICATION; PLANT-GROWTH; CHITOSAN; QUALITY; L. | Amalia; Chitosan; Claudia; Contribution; NaCl; Salinity | Chlorophyll; Photosynthesis; Salinity; Salt Stress; Soil; Solanum lycopersicum; Water; chlorophyll; water; chemistry; growth, development and aging; metabolism; photosynthesis; physiology; salinity; salt stress; soil; tomato | English | 2024 | 2024-12-30 | 10.1038/s41598-024-82211-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Mobile monitoring system detects the disease activity pattern and shows the association with clinical outcomes in patients with newly diagnosed Crohn's disease | We aimed to determine whether Crohn's disease (CD) activity patterns assessed via a web-based symptom diary can help predict clinical outcomes in patients with newly diagnosed CD. Patients diagnosed with CD within the preceding 3 months were prospectively enrolled at four tertiary centers. All patients recorded their symptoms on a website using a smartphone at least once a week. The index outcomes were disease-related admission and surgery during follow-up. The disease activity from enrollment to outcome or last follow-up was reviewed for pattern analysis. Cox regression analysis was used to identify the predictors of disease outcomes. A total of 102 patients were enrolled. During a median follow-up period of 42 months, 25 (24.5%) and 6 (5.9%) patients required admission and surgery, respectively. Poor activity pattern was an independent predictor of disease-related hospitalization (adjusted hazard ratio [aHR], 3.96; 95% confidence interval [CI] 1.5-10.45; p = 0.005). A poor activity pattern (aHR, 19.48; 95% CI 1.86-203.95; p = 0.013) and female sex (aHR, 11.28; 95% CI 1.49-85.01; p = 0.018) were found to be independent predictors of bowel resection. CD disease activity patterns monitored through the mobile monitoring system may help predict clinical outcomes, such as disease-related hospitalization and surgery, in patients with newly diagnosed CD. | Lee, Yoo Jin; Kwak, Sang Gyu; Kim, Eun Soo; Kim, Sung Kook; Lee, Hyun Seok; Chung, Yun Jin; Jang, Byung Ik; Kim, Kyeong Ok; Kim, Jeongseok; Jo, Hyeong Ho; Kim, Eun Young | Keimyung Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Catholic Univ Daegu, Sch Med, Dept Med Stat, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, 130 Dongdeuk Ro, Daegu, South Korea; Yeungnam Univ, Coll Med, Dept Internal Med, 317-1 Daemyung 5 Dong, Daegu 705703, South Korea; Catholic Univ Daegu, Sch Med, Dept Internal Med, Daegu, South Korea | Kim, Sang/J-5398-2012; Lee, Jong-Seok/J-5603-2012; kim, Seok-jun/E-7924-2015; Kim, Sun/C-2026-2011; Kim, Eun Young/JCE-3602-2023; Jo, Hyeong Ho/LFU-2981-2024; Kwak, Sang Gyu/AAG-4341-2021 | 55531365900; 56645812600; 57203086704; 34770060400; 36647886100; 57199411938; 22953491400; 53363798100; 55636277000; 57544016800; 58889004100 | dandy813@knu.ac.kr;jbi@med.yu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0.41 | 2025-05-07 | 1 | 1 | INFLAMMATORY-BOWEL-DISEASE; RANDOMIZED CONTROLLED-TRIAL; ULCERATIVE-COLITIS; HEALTH; CHILDREN; CARE; MANAGEMENT; SURGERY; INDEX; RISK | Adolescent; Adult; Crohn Disease; Female; Follow-Up Studies; Hospitalization; Humans; Male; Middle Aged; Mobile Applications; Prospective Studies; Smartphone; Telemedicine; Young Adult; adolescent; adult; Crohn disease; female; follow up; hospitalization; human; male; middle aged; procedures; prospective study; telemedicine; young adult | English | 2024 | 2024-04-24 | 10.1038/s41598-024-59914-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Novel electroporation microchip with field constriction enhances transfection efficiency and survival rates of feline embryos | This study introduces a low-voltage electroporation microchip designed for transfection in cat embryos, featuring real-time impedance monitoring. The microchip uses a field constriction strategy, which localises the electric field to the membrane region in contact with the micro-orifice, enhancing electroporation efficiency while minimising damage. Embryos were positioned on the orifice, and a series of voltage pulses (10, 15, and 20 V) were applied. Electroporation efficacy was assessed using fluorescent dyes, followed by real-time impedance measurements to monitor the membrane resealing time. It provided valuable insights into membrane recovery times, essential for optimizing gene editing conditions to ensure efficient delivery and maintain cell integrity. The results demonstrated that the microchip with 15 V achieved a 69.5% higher electroporation rate and 100% of survival compared to conventional devices (p < 0.05). Additionally, the microchip successfully facilitated the transfer of green fluorescent protein genes into embryos, achieving a 78.5% success rate significantly greater compared to 53.6% with the conventional device (p < 0.05). This innovative microchip provides transformative transfection technology for safer and more efficient genomic modifications in embryos. It holds promising applications across species and therapeutic interventions, paving the way for future studies in advanced genomic research. | Kallayanathum, Wirakan; Techaumnat, Boonchai; Panklang, Nitipong; Sripumkhai, Witsaroot; Jeamsaksiri, Wutthinan; Koo, Okjae; Jang, Goo; Tharasanit, Theerawat | Chulalongkorn Univ, Fac Vet Sci, Dept Obstet Gynaecol & Reprod, Bangkok 10330, Thailand; Chulalongkorn Univ, Ctr Excellence Vet Clin Stem Cells & Bioengn, Bangkok 10330, Thailand; Chulalongkorn Univ, Fac Engn, Dept Elect Engn, Bangkok 10330, Thailand; Chulalongkorn Univ, Fac Engn, Micro Nanoelectromech Integrated Syst Res Unit, Bangkok 10330, Thailand; Rajamangala Univ Technol Thanyaburi, Fac Engn, Dept Elect Engn, Pathum Thani 12120, Thailand; Natl Sci & Technol Dev Agcy NSTDA, Thai Microelect Ctr TMEC, Chachoengsao 24000, Thailand; Kyungpook Natl Univ, Coll Vet Med, Daegu, South Korea; nSAGE Inc, Incheon, South Korea; Seoul Natl Univ, Coll Vet Med, Dept Vet Clin Sci, Seoul 08826, South Korea; Seoul Natl Univ, Res Inst Vet Sci, Seoul 08826, South Korea | Jeamsaksiri, Wutthinan/H-5422-2013; /Q-9921-2019 | 57218795023; 6603630440; 56340254300; 35362668400; 6602330442; 57197017299; 8960743100; 8606515700 | theerawat.t@chula.ac.th; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0 | 2025-05-07 | 0 | 0 | Cat; Electroporation; Embryo; Field constriction; Microchip; Resealing time | IMPEDANCE SPECTROSCOPY; MEMBRANE; DELIVERY; ORIFICE; PULSES; CELLS; CHIP; CAT | Cat; Electroporation; Embryo; Field constriction; Microchip; Resealing time | Animals; Cats; Electroporation; Embryo, Mammalian; Green Fluorescent Proteins; Lab-On-A-Chip Devices; Transfection; green fluorescent protein; animal; cat; devices; electroporation; genetic transfection; genetics; lab on a chip; mammalian embryo; metabolism; procedures | English | 2024 | 2024-11-27 | 10.1038/s41598-024-80494-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | On body and off body communication using a compact wideband and high gain wearable textile antenna | In this paper, a compact low-profile dual-band wearable textile antenna is proposed for on-body and off-body communications. The presented antenna works efficiently in the 5G n79 frequency band (4.4 - 5 GHz) and the ISM band (5.725 - 5.875 GHz). The designed antenna has an ultra-wide impedance bandwidth of 2.01 GHz and peak realized gains of 10.5 dBi and 12 dBi at 4.5 GHz and 5.8 GHz, respectively. The antenna has a small footprint (pi x 0.3 lambda 02), which is inspired by circular fractal geometry. The performance of the presented wearable antenna is evaluated at various body parts, including the arm, wrist, and chest. The link margin is evaluated in the on-body and off-body communication scenarios, i.e., communication with the implantable antenna and the outside-body antenna, which is 80 dB and 65 dB at 4.5 GHz and 5.8 GHz, respectively. The 1 gm/10 gm specific absorption rate values at 4.5 GHz and 5.8 GHz are 0.12/0.098 and 0.11/0.082, respectively, which are significantly lower than the standard values, making the proposed antenna suitable for modern wearable applications. | Sharma, Deepti; Kumar, Sachin; Tiwari, Rakesh Nath; Choi, Hyun Chul; Kim, Kang Wook | GL Bajaj Inst Technol & Management, Dept Elect & Commun Engn, Greater Noida 201306, Uttar Pradesh, India; Galgotias Coll Engn & Technol, Dept Elect & Commun Engn, Greater Noida 201310, Uttar Pradesh, India; Madanapalle Inst Technol & Sci, Dept Elect & Commun Engn, Madanapalle 517325, Andhra Prades, India; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | Sharma, Deepti/KYO-8662-2024; Tiwari, Rakesh/AAR-5945-2020; Tiwari, Dr. Rakesh Nath/AAR-5945-2020; Kumar, Sachin/W-2211-2019 | 57225937894; 56907994000; 57198002672; 57193342681; 57204432422 | gupta.sachin0708@gmail.com;kang_kim@ee.knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 2.86 | 2025-05-07 | 11 | 15 | FRACTAL ANTENNA | absorption; article; bandwidth; body regions; controlled study; female; geometry; impedance; male; respiratory gas humidifier; textile; wearable device; wrist | English | 2024 | 2024-06-24 | 10.1038/s41598-024-64932-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Peroxiredoxin 1 inhibits streptozotocin-induced Alzheimer's disease-like pathology in hippocampal neuronal cells via the blocking of Ca²⁺/Calpain/Cdk5-mediated mitochondrial fragmentation | Oxidative stress plays an essential role in the progression of Alzheimer's disease (AD), the most common age-related neurodegenerative disorder. Streptozotocin (STZ)-induced abnormal brain insulin signaling and oxidative stress play crucial roles in the progression of Alzheimer's disease (AD)-like pathology. Peroxiredoxins (Prxs) are associated with protection from neuronal death induced by oxidative stress. However, the molecular mechanisms underlying Prxs on STZ-induced progression of AD in the hippocampal neurons are not yet fully understood. Here, we evaluated whether Peroxiredoxin 1 (Prx1) affects STZ-induced AD-like pathology and cellular toxicity. Prx1 expression was increased by STZ treatment in the hippocampus cell line, HT-22 cells. We evaluated whether Prx1 affects STZ-induced HT-22 cells using overexpression. Prx1 successfully protected the forms of STZ-induced AD-like pathology, such as neuronal apoptosis, synaptic loss, and tau phosphorylation. Moreover, Prx1 suppressed the STZ-induced increase of mitochondrial dysfunction and fragmentation by down-regulating Drp1 phosphorylation and mitochondrial location. Prx1 plays a role in an upstream signal pathway of Drp1 phosphorylation, cyclin-dependent kinase 5 (Cdk5) by inhibiting the STZ-induced conversion of p35 to p25. We found that STZ-induced of intracellular Ca2+ accumulation was an important modulator of AD-like pathology progression by regulating Ca2+-mediated Calpain activation, and Prx1 down-regulated STZ-induced intracellular Ca2+ accumulation and Ca2+-mediated Calpain activation. Finally, we identified that Prx1 antioxidant capacity affected Ca2+/Calpain/Cdk5-mediated AD-like pathology progress. Therefore, these findings demonstrated that Prx1 is a key factor in STZ-induced hippocampal neuronal death through inhibition of Ca2+/Calpain/Cdk5-mediated mitochondrial dysfunction by protecting against oxidative stress. | Park, Junghyung; Won, Jinyoung; Yang, Eunyeoung; Seo, Jincheol; Cho, Jiyeon; Seong, Jung Bae; Yeo, Hyeon-Gu; Kim, Keonwoo; Kim, Yu Gyeong; Kim, Minji; Jeon, Chang-Yeop; Lim, Kyung Seob; Lee, Dong-Seok; Lee, Youngjeon | Korea Res Inst Biosci & Biotechnol KRIBB, Natl Primate Res Ctr, Cheongju, South Korea; Univ Seoul, Dept Life Sci, Seoul, South Korea; Korea Univ Sci & Technol UST, KRIBB Sch Biosci, Daejeon, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu, South Korea; Korea Adv Inst Sci & Technol KAIST, Dept Bio & Brain Engn, Daejeon, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Futurist Anim Resource & Res Ctr, Cheongju, South Korea | Lee, Youngjeon/LZH-8969-2025 | 55671747100; 56018670200; 58868611800; 57200518242; 57976410100; 57202134219; 56263762800; 57204572034; 57219109450; 57199746462; 56522472100; 36470521900; 57210068061; 57199022088 | lee1@knu.ac.kr;neurosci@kribb.re.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 1.23 | 2025-05-07 | 4 | 3 | Peroxiredoxin 1(Prx1); Oxidative stress; Alzheimer's disease (AD); Streptozotocin; Calpain; Mitochondria | CYCLIN-DEPENDENT KINASE-5; AMYLOID-BETA; OXIDATIVE STRESS; MOUSE MODEL; INTRACEREBROVENTRICULAR INJECTION; SYNAPTIC DEGENERATION; PROTECTIVE ROLE; MONKEY MODEL; ACTIVATION; CDK5 | Alzheimer’s disease (AD); Calpain; Mitochondria; Oxidative stress; Peroxiredoxin 1(Prx1); Streptozotocin | Alzheimer Disease; Animals; Apoptosis; Calcium; Calpain; Cell Line; Cyclin-Dependent Kinase 5; Dynamins; Hippocampus; Mice; Mitochondria; Neurons; Oxidative Stress; Peroxiredoxins; Phosphorylation; Signal Transduction; Streptozocin; tau Proteins; calcium; calpain; Cdk5 protein, mouse; cyclin dependent kinase 5; Dnm1l protein, mouse; dynamin; peroxiredoxin; Prdx1 protein, mouse; streptozocin; tau protein; Alzheimer disease; animal; apoptosis; cell line; etiology; genetics; hippocampus; metabolism; mitochondrion; mouse; nerve cell; oxidative stress; pathology; phosphorylation; signal transduction | English | 2024 | 2024-07-08 | 10.1038/s41598-024-66256-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Phylogenetic relationships and genetic diversity of the Korean endemic Phedimus latiovalifolius (Crassulaceae) and its close relatives | Phedimus latiovalifolius (Y.N.Lee) D.C.Son & H.J.Kim is exclusively distributed in the high mountains in the Korean Peninsula, mainly along the Baekdudaegan mountain range. Despite its morphological and distributional distinction from other Phedimus Raf. species, its taxonomic identity and phylogenetic relationship with congeneric species remain unclear. This study employs genotyping-by-sequencing-derived genome-wide single nucleotide polymorphisms to establish the monophyly of P. latiovalifolius and its relationship with closely related species. Genetic diversity and population differentiation of P. latiovalifolius are also assessed to provide baseline genetic information for future conservation and management strategies. Our phylogenetic analyses robustly demonstrate the monophyletic nature of P. latiovalifolius, with P. aizoon (L.) 't Hart identified as its closest sister lineage. There is no genetic evidence supporting a hybrid origin of P. latiovalifolius from P. aizoon involving either P. ellacombeanus (Praeger) 't Hart or P. kamtschaticus (Fisch.) 't Hart. Population genetic analyses reveal two major groups within P. latiovalifolius. A higher genetic variation is observed in P. ellacombeanus than in the congeneric species. Notably, most of the genetic variation exists within P. latiovalifolius populations. Given its distribution and the potential role of Baekdudaegan as an East Asian Pleistocene refugia, P. latiovalifolius could be considered rare and endemic, persisting in the refugium across glacial/interglacial cycles. | Cho, Myong-Suk; Kim, Yongsung; Kim, Seon-Hee; Jeon, Ji-Hyeon; Yang, Jiyoung; Kim, Seung-Chul | Sungkyunkwan Univ, Dept Biol Sci, Suwon 16419, South Korea; Honam Natl Inst Biol Resources, Mokpo 58762, South Korea; Kyoto Univ, Grad Sch Sci, Dept Bot, Sakyo Ku, Kyoto 6068502, Japan; Kyungpook Natl Univ, Inst Dok Do & Ulleung Do Isl, Daegu 41566, South Korea | Kim, Seung-Chul/AAR-6157-2020; Jeon, Ji-Hyeon/AAT-9101-2020 | 56326352700; 57204393669; 57196226213; 57204430870; 55193226000; 57214983739 | sonchus96@skku.edu; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0 | 2025-05-07 | 1 | 0 | Genetic diversity; Crassulaceae; Single nucleotide polymorphisms; Glacial refugium; Baekdudaegan; Korean | SUBGENUS AIZOON CRASSULACEAE; CHROMOSOME-NUMBERS; DNA HAPLOTYPES; TOOL SET; IQ-TREE; PHYLOGEOGRAPHY; CHINA; CHLOROPLAST; DISPERSAL; PENINSULA | Baekdudaegan; Crassulaceae; Genetic diversity; Glacial refugium; Korean; Single nucleotide polymorphisms | Genetic Variation; Phylogeny; Polymorphism, Single Nucleotide; Republic of Korea; article; controlled study; Crassulaceae; genetic analysis; genetic variability; genetic variation; genotype; genotyping; interglacial; Korean (people); monophyly; mountain ranges; nonhuman; phylogeny; Pleistocene; population differentiation; refugium; single nucleotide polymorphism; single nucleotide polymorphism; South Korea | English | 2024 | 2024-07-15 | 10.1038/s41598-024-63272-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Correction | Precise control of liposome size using characteristic time depends on solvent type and membrane properties(vol13, 4728, 2023) | Choi, Sunghak; Kang, Bongsu; Yang, Eunhye; Kim, Keesung; Kwak, Moon Kyu; Chang, Pahn-Shick; Jung, Ho-Sup | Seoul Natl Univ, Ctr Food & Bioconvergence, Dept Food & Anim Biotechnol, Seoul 08826, South Korea; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Seoul Natl Univ, Dept Agr Biotechnol, Seoul 08826, South Korea; Seoul Natl Univ, Res Inst Adv Mat RIAM, Coll Engn, Seoul 08826, South Korea; Seoul Natl Univ, Ctr Agr Microorganism & Enzyme, Seoul 08826, South Korea; Seoul Natl Univ, Res Inst Agr & Life Sci, Seoul 08826, South Korea; Nbiocell Inc, Siheung SNU Start Up Campus, Shihung 15011, Gyeonggi Do, South Korea | Kwak, Moon/F-2786-2012; Yang, Eunhye/MHQ-9506-2025; Jung, Hosup/AAB-5708-2020 | 57264013200; 55330925300; 57205348562; 35484342500; 57203947984; 35749476600; 36985354800 | mkkwak@knu.ac.kr;pschang@snu.ac.kr;jhs@snu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0 | 2025-05-07 | 0 | 0 | liposome; solvent; agriculture; article; food handling; forestry; government; international cooperation; Korea; livestock; controlled study; erratum; human; therapy | English | 2024 | 2024-03-04 | 10.1038/s41598-024-55878-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Predicting early mortality in hemodialysis patients: a deep learning approach using a nationwide prospective cohort in South Korea | Early mortality after hemodialysis (HD) initiation significantly impacts the longevity of HD patients. This study aimed to quantify the effect sizes of risk factors on mortality using various machine learning approaches. A cohort of 3284 HD patients from the CRC-ESRD (2008-2014) was analyzed. Mortality risk models were validated using logistic regression, ridge regression, lasso regression, and decision trees, as well as ensemble methods like bagging and random forest. To better handle missing data and time-series variables, a recurrent neural network (RNN) with an autoencoder was also developed. Additionally, survival models predicting hazard ratios were employed using survival analysis techniques. The analysis included 1750 prevalent and 1534 incident HD patients (mean age 58.4 +/- 13.6 years, 59.3% male). Over a median follow-up of 66.2 months, the overall mortality rate was 19.3%. Random forest models achieved an AUC of 0.8321 for first-year mortality prediction, which was further improved by the RNN with autoencoder (AUC 0.8357). The survival bagging model had the highest hazard ratio predictability (C-index 0.7756). A shorter dialysis duration (< 14.9 months) and high modified Charlson comorbidity index scores (7-9) were associated with hazard ratios up to 7.76 (C-index 0.7693). Comorbidities were more influential than age in predicting early mortality. Monitoring dialysis adequacy (KT/V), RAAS inhibitor use, and urine output is crucial for assessing early prognosis. | Noh, Junhyug; Park, Sun Young; Bae, Wonho; Kim, Kangil; Cho, Jang-Hee; Lee, Jong Soo; Kang, Shin-Wook; Kim, Yong-Lim; Kim, Yon Su; Lim, Chun Soo; Lee, Jung Pyo; Yoo, Kyung Don | Ewha Womans Univ, Dept Artificial Intelligence, Seoul, South Korea; Univ Ulsan, Ulsan Univ Hosp, Coll Med, Dept Internal Med, Ulsan, South Korea; Univ British Columbia, Vancouver, BC, Canada; Gwangju Inst Sci & Technol GIST, Sch Elect Engn & Comp Sci, Gwangju, South Korea; Kyungpook Natl Univ, Coll Med, Dept Internal Med, Daegu, South Korea; Univ Ulsan, Basic Clin Convergence Res Inst, Ulsan, South Korea; Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Boramae Med Ctr, Dept Internal Med, Div Nephrol, Seoul, South Korea | Cho, Jang-hee/ABD-3534-2020; Kim, Kangil/MHQ-0084-2025; Noh, Junhyug/ADR-6172-2022; Kim, Yong-Lim/AGK-3172-2022; Yoo, Kyung/AAK-8096-2020 | 56878320200; 58645312600; 57696326500; 36622862500; 7403536291; 57201264463; 34768359700; 55633533600; 56066702900; 57214943908; 56028990400; 56603636300 | jungpyolee@snu.ac.kr;ykd9062@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0.41 | 2025-05-07 | 0 | 1 | End-stage kidney disease; Deep learning; Machine learning; Hemodialysis; Survival analysis | PATIENTS STARTING DIALYSIS; ELDERLY-PATIENTS; DECISION-MAKING; RISK SCORE; VALIDATION; DEATH; MODELS | Deep learning; End-stage kidney disease; Hemodialysis; Machine learning; Survival analysis | Adult; Aged; Deep Learning; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Prospective Studies; Renal Dialysis; Republic of Korea; Risk Factors; Survival Analysis; adult; aged; chronic kidney failure; deep learning; epidemiology; female; hemodialysis; human; male; middle aged; mortality; prospective study; risk factor; South Korea; survival analysis; therapy | English | 2024 | 2024-11-29 | 10.1038/s41598-024-80900-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Predicting seasonal influenza outbreaks with regime shift-informed dynamics for improved public health preparedness | In this study, we propose a novel approach that integrates regime-shift detection with a mechanistic model to forecast the peak times of seasonal influenza. The key benefit of this approach is its ability to detect regime shifts from non-epidemic to epidemic states, which is particularly beneficial with the year-round presence of non-zero Influenza-Like Illness (ILI) data. This integration allows for the incorporation of external factors that trigger the onset of the influenza season-factors that mechanistic models alone might not adequately capture. Applied to ILI data collected in Korea from 2005 to 2020, our method demonstrated stable peak time predictions for seasonal influenza outbreaks, particularly in years characterized by unusual onset times or epidemic magnitudes. | Kim, Minhye; Kim, Yongkuk; Nah, Kyeongah | Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea; Natl Inst Math Sci, Busan Ctr Med Math, Busan 49241, South Korea | 59153685200; 7410204041; 36880543200 | knah@nims.re.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0.41 | 2025-05-07 | 1 | 1 | SURVEILLANCE; BURDEN; MODELS | Disease Outbreaks; Forecasting; Humans; Influenza, Human; Public Health; Republic of Korea; Seasons; epidemic; epidemiology; forecasting; human; influenza; prevention and control; procedures; public health; season; South Korea | English | 2024 | 2024-06-03 | 10.1038/s41598-024-63573-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Preoperative smoking and robot-assisted radical cystectomy outcomes & complications in multicenter KORARC database | To investigate the influence of preoperative smoking history on the survival outcomes and complications in a cohort from a large multicenter database. Many patients who undergo radical cystectomy (RC) have a history of smoking; however, the direct association between preoperative smoking history and survival outcomes and complications in patients with muscle-invasive bladder cancer (MIBC) who undergo robot-assisted radical cystectomy (RARC) remains unexplored. We conducted a retrospective analysis using data from 749 patients in the Korean Robot-Assisted Radical Cystectomy Study Group (KORARC) database, with an average follow-up duration of 30.8 months. The cohort was divided into two groups: smokers (n = 351) and non-smokers (n = 398). Propensity score matching was employed to address differences in sample size and baseline demographics between the two groups (n = 274, each). Comparative analyses included assessments of oncological outcomes and complications. After matching, smoking did not significantly affect the overall complication rate (p = 0.121). Preoperative smoking did not significantly increase the occurrence of complications based on complication type (p = 0.322), nor did it increase the readmission rate (p = 0.076). There were no perioperative death in either group. Furthermore, preoperative smoking history showed no significant impact on overall survival (OS) [hazard ratio (HR) = 0.87, interquartile range (IQR): 0.54-1.42; p = 0.589] and recurrence-free survival (RFS) (HR = 1.12, IQR: 0.83-1.53; p = 0.458) following RARC for MIBC. The extent of preoperative smoking (= 30 pack-years) had no significant influence on OS and RFS in any of the categories (all p > 0.05). Preoperative smoking history did not significantly affect OS, RFS, or complications in patients with MIBC undergoing RARC. | Choi, Joongwon; Lee, Jooyoung; Hwang, Yu Been; Jeong, Byong Chang; Lee, Sangchul; Ku, Ja Hyeon; Nam, Jong Kil; Kim, Wansuk; Lee, Ji Youl; Hong, Sung Hoo; Rha, Koon Ho; Han, Woong Kyu; Ham, Won Sik; Kang, Sung Gu; Kang, Seok Ho; Oh, Jong Jin; Lee, Young Goo; Kwon, Tae Gyun; Kim, Tae-Hwan; Jeon, Seung Hyun; Lee, Sang Hyub; Park, Sung Yul; Yoon, Young Eun; Lee, Yong Seong | Chung Ang Univ, Gwangmyeong Hosp, Dept Urol, Coll Med, Gwangmyeong, South Korea; Chung Ang Univ, Dept Appl Stat, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Urol, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Urol, Seongnam, South Korea; Seoul Natl Univ, Coll Med, Dept Urol, Seoul, South Korea; Pusan Natl Univ, Yangsan Hosp, Dept Urol, Yangsan, South Korea; Ewha Womans Univ, Mokdong Hosp, Dept Urol, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Dept Urol, Coll Med, Seoul, South Korea; Yonsei Univ, Coll Med, Severance Hosp, Dept Urol, Seoul, South Korea; Korea Univ, Coll Med, Dept Urol, Seoul, South Korea; Hallym Univ, Sch Med, Dept Urol, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu, South Korea; Kyung Hee Univ, Dept Urol, Coll Med, Seoul, South Korea; Hanyang Univ, Coll Med, Dept Urol, Seoul, South Korea | ; Choi, Joongwon/ABG-8559-2021; Ku, Ja/E-6682-2016; Lee, Hye/J-2154-2015; Yoon, Youngeun/HOC-1137-2023; Kim, Tae-Hwan/M-3962-2017; Jeon, Seung Hyun/AFN-3212-2022 | 57208742789; 57209532882; 59067544200; 7102237943; 57202327303; 36800523000; 8653467500; 57049819200; 57202074202; 37030299600; 7003388459; 7401899857; 23097952400; 35995660400; 7405684686; 24468588100; 15033760000; 15073765400; 57797823600; 7203005251; 57265524000; 57207888185; 58825663400; 36068330000 | yongslee@cau.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0 | 2025-05-07 | 0 | 0 | Bladder cancer; Smoking; Cystectomy; Survival analysis; Robot-assisted surgery | BLADDER-CANCER; TUMOR RECURRENCE; IMPACT; RISK | Bladder cancer; Cystectomy; Robot-assisted surgery; Smoking; Survival analysis | Aged; Cystectomy; Databases, Factual; Female; Humans; Male; Middle Aged; Postoperative Complications; Preoperative Period; Republic of Korea; Retrospective Studies; Robotic Surgical Procedures; Smoking; Treatment Outcome; Urinary Bladder Neoplasms; aged; bladder tumor; clinical trial; cystectomy; factual database; female; human; male; middle aged; mortality; multicenter study; pathology; postoperative complication; preoperative period; procedures; retrospective study; robot assisted surgery; smoking; South Korea; treatment outcome | English | 2024 | 2024-05-08 | 10.1038/s41598-024-61005-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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