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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Changes in Clinical Characteristics of Community-Acquired Acute Pyelonephritis and Antimicrobial Resistance of UropathogenicEscherichia coliin South Korea in the Past Decade | This study examined changes in the clinical characteristics of community-acquired acute pyelonephritis (CA-APN) in South Korea between the period 2010-2011 and 2017-2018. We recruited all CA-APN patients aged >= 19 years who visited eight hospitals in South Korea from September 2017 to August 2018, prospectively. Data collected were compared with those from the previous study in 2010-2012, with the same design and participation from 11 hospitals. A total of 617 patients were enrolled and compared to 818 patients' data collected in 2010-2011.Escherichia coliwas the most common causative pathogen of CA-APN in both periods (87.3% vs. 86.5%,p= 0.680).E. coliisolates showed significantly higher antimicrobial resistance against fluoroquinolone (32.0% vs. 21.6%,p< 0.001), cefotaxime (33.6% vs. 8.3%,p< 0.001), and trimethoprim/sulfamethoxazole (37.5% vs. 29.2%,p= 0.013) in 2017-2018 than in 2010-2011. Total duration of antibiotic treatment increased from 16.55 +/- 9.68 days in 2010-2011 to 19.12 +/- 9.90 days in 2017-2018 (p< 0.001); the duration of carbapenem usage increased from 0.59 +/- 2.87 days in 2010-2011 to 1.79 +/- 4.89 days in 2010-2011 (p< 0.001). The median hospitalization was higher for patients in 2017-2018 than in 2010-2011 (9 vs. 7 days,p< 0.001). In conclusion, antimicrobial resistance ofE. colito almost all antibiotic classes, especially third generation cephalosporin, increased significantly in CA-APN in South Korea. Consequently, total duration of antibiotic treatment, including carbapenem usage, increased. | Kwon, Ki Tae; Kim, Bongyoung; Ryu, Seong-yeol; Wie, Seong-Heon; Kim, Jieun; Jo, Hyun-uk; Park, Se Yoon; Hong, Kyung-Wook; Kim, Hye In; Kim, Hyun Ah; Kim, Mi-Hee; Bae, Mi Hyun; Sohn, Yong-Hak; Lee, Yangsoon; Pai, Hyunjoo | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu 41566, South Korea; Hanyang Univ, Coll Med, Dept Internal Med, Seoul 04763, South Korea; Keimyung Univ, Dept Internal Med, Dongsan Med Ctr, Daegu 41931, South Korea; Catholic Univ Korea, Coll Med, St Vincent Hosp, Div Infect Dis,Dept Internal Med, Seoul 06591, South Korea; Eulji Univ, Sch Med, Dept Urol, Daejeon 34824, South Korea; Soonchunhyang Univ, Dept Internal Med, Div Infect Dis, Seoul Hosp,Coll Med, Seoul 04401, South Korea; Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Dept Internal Med, Div Infect Dis,Sch Med, Jinju 52727, South Korea; Daegu Fatima Hosp, Dept Internal Meidcine, Daegu 41199, South Korea; Hanyang Univ, Coll Med, Dept Lab Med, Seoul 04763, South Korea; Seegene Med Fdn, Seoul 04805, South Korea; Soonchunhyang Univ, Dept Lab Med, Seoul Hosp, Coll Med, Seoul 04401, South Korea | ; Kim, Bongyoung/H-3409-2018; Hong, Kyung-Wook/T-3067-2018; Pai, Hyunjoo/M-7492-2018; Kim, Jong/K-3445-2013; Kim, Woo/AAG-1822-2019; Lee, Yangsoon/C-9751-2015; Hwang, Soyoon/HHM-5762-2022; Kim, Ji/AAU-5043-2020 | 9733850500; 55622077200; 9733513600; 12796392700; 51963871600; 57219027371; 55259986400; 38461203300; 57208153832; 57059615500; 56001471000; 57032150100; 35270009900; 56528660800; 56107271700; 7004631730 | ktkwon@knu.ac.kr;sobakas@hanyang.ac.kr;121rsy@dsmc.or.kr;wiesh@catholic.ac.kr;jkim1220@schmc.ac.kr;hujo@eulji.ac.kr;sypark@schmc.ac.kr;resina78@gnuh.co.kr;cheonlang1@hanmail.net;hyunah1118@dsmc.or.kr;miheekim3528@gmail.com;mhbae@hanyang.ac.kr;medsohn@naver.com;yangsoon@hanyang.ac.kr;paihj@hanyang.ac.kr; | ANTIBIOTICS-BASEL | ANTIBIOTICS-BASEL | 2079-6382 | 9 | 9 | SCIE | INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY | 2020 | 4.639 | 27.4 | 1 | 2025-06-25 | 8 | 11 | pyelonephritis; urinary tract infection; antimicrobial resistance; Korea | URINARY-TRACT-INFECTIONS; ONSET ACUTE PYELONEPHRITIS; ESCHERICHIA-COLI; ANTIBIOTIC-TREATMENT; DISEASES-SOCIETY; RISK-FACTORS; SUSCEPTIBILITY; EPIDEMIOLOGY; BACTEREMIA; CARBAPENEM | Antimicrobial resistance; Korea; Pyelonephritis; Urinary tract infection | amikacin; amoxicillin plus clavulanic acid; aztreonam; cefazolin; cefepime; cefotaxime; ceftazidime; cotrimoxazole; extended spectrum beta lactamase; gentamicin; imipenem; piperacillin; piperacillin plus tazobactam; sultamicillin; tobramycin; adult; antibiotic resistance; antibiotic sensitivity; Article; bacteremia; cephalosporin resistance; Charlson Comorbidity Index; cohort analysis; colony forming unit; community acquired infection; creatinine blood level; Escherichia coli; female; fluoroquinolone resistance; human; male; prospective study; pyelonephritis; urea nitrogen blood level; urinary tract infection | English | 2020 | 2020-09 | 10.3390/antibiotics9090617 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Protection against UVB-Induced Photoaging by Nypa fruticans via Inhibition of MAPK/AP-1/MMP-1 Signaling | Ultraviolet B (UVB) irradiation is major causative factor in skin aging. The aim of the present study was to investigate the protective effect of a 50% ethanol extract fromNypa fruticans(NF50E) against UVB-induced skin aging. The results indicated that NF50E exerted potent antioxidant activity (IC50 = 17.55 +/- 1.63 and 10.78 +/- 0.63 mu g/mL for DPPH and ABTS-radical scavenging activity, respectively) in a dose-dependent manner. High-performance liquid chromatography revealed that pengxianencin A, protocatechuic acid, catechin, chlorogenic acid, epicatechin, and kaempferol were components of the extract. In addition, the extract exhibited elastase inhibitory activity (IC50 = 17.96 +/- 0.39 mu g/mL). NF50E protected against UVB-induced HaCaT cell death and strongly suppressed UVB-stimulated cellular reactive oxygen species generation without cellular toxicity. Moreover, topical application of NF50E mitigated UVB-induced photoaging lesions including skin erythema and skin thickness in BALB/C mice. NF50E treatment inhibited UVB-induced collagen degradation as well as MMP-1 and IL-1 beta expressions and significantly stimulated SIRT1 expression. Furthermore, the extract treatment markedly suppressed the activation of NF-kappa B and AP-1 (p-c-Jun) by deactivating the p38 and JNK proteins. Taken together, current data suggest that NF50E exhibits potent antioxidant potential and protection against photoaging by attenuating MMP-1 activity and collagen degradation possibly through the downregulation of MAPK/NF-kappa B/AP-1 signaling and SIRT1 activation. | Choi, Hee-Jeong; Alam, Md Badrul; Baek, Mi-Eun; Kwon, Yoon-Gyung; Lim, Ji-Young; Lee, Sang-Han | Kyungpook Natl Univ, Grad Sch, Dept Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Inner Beauty Antiaging Ctr, Food & Bioind Res Inst, Daegu 41566, South Korea; Knu BnC, Daegu 41566, South Korea | Alam, Md Badrul/AAK-7176-2021; Lee, Seung Eun/ABG-1607-2021 | 57201125608; 56706777100; 57201398003; 59102005400; 57203527486; 57221453703 | sang@knu.ac.kr; | OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | OXID MED CELL LONGEV | 1942-0900 | 1942-0994 | 2020 | SCIE | CELL BIOLOGY | 2020 | 6.543 | 27.4 | 1.73 | 2025-06-25 | 49 | 55 | I PROCOLLAGEN SYNTHESIS; HUMAN SKIN; MATRIX METALLOPROTEINASES; ULTRAVIOLET-RADIATION; EXTRACT; EXPRESSION; CASCADES; ELASTASE; COLLAGEN | Activation; Aging; Chlorogenic Acid; Collagen; Degradation; Ethanol; Processing; Ultraviolet Radiation; Animals; Disease Models, Animal; Humans; Matrix Metalloproteinase 1; Mice; Plant Extracts; Signal Transduction; Skin Aging; Ultraviolet Rays; Antioxidants; Cell death; Chemical activation; Collagen; Flavonoids; High performance liquid chromatography; Mammals; antioxidant; ascorbic acid; catechin; chlorogenic acid; collagenase 3; elastase; elastase inhibitor; epicatechin; epigallocatechin gallate; immunoglobulin enhancer binding protein; interleukin 1beta; interstitial collagenase; kaempferol; messenger RNA; mitogen activated protein kinase 1; mitogen activated protein kinase 3; mitogen activated protein kinase p38; neutrophil collagenase; Nypa fruticans extract; pengxianencin A; phytochemical; plant extract; protein c jun; protocatechuic acid; radioprotective agent; reactive oxygen metabolite; sirtuin 1; skin protective agent; stress activated protein kinase; transcription factor AP 1; unclassified drug; interstitial collagenase; plant extract; Cellular reactive oxygen species; Cellular toxicities; Collagen degradations; Dose-dependent manner; Potent antioxidants; Protocatechuic acid; Radical scavenging activity; Topical application; ABTS radical scavenging assay; animal experiment; animal model; animal tissue; antioxidant activity; Arecaceae; Article; Bagg albino mouse; cell protection; collagen degradation; controlled study; down regulation; DPPH radical scavenging assay; drug efficacy; drug mechanism; drug potency; enzyme inhibition; erythema; ethnopharmacology; HaCat cell line; human; human cell; IC50; in vitro study; in vivo study; liquid chromatography-mass spectrometry; mouse; mRNA expression level; nonhuman; Nypa fruticans; oxidative stress; photoaging; phytochemistry; protein expression level; protein phosphorylation; radiation protection; signal transduction; skin defect; skin protection; skinfold thickness; topical treatment; ultraviolet B radiation; adverse event; animal; chemistry; cutaneous parameters; disease model; drug effect; metabolism; signal transduction; ultraviolet radiation; Plants (botany) | English | 2020 | 2020-06-23 | 10.1155/2020/2905362 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Quadrella incana (Capparaceae) Leaf Extract Enhances Proliferation and Maintenance of Neural Stem/Progenitor Cells through Upregulating Glycolytic Flux and Redox Potential | Neural stem/progenitor cells (NSPCs) are self-renewing, multipotent cells located in the embryonic and adult central nervous system (CNS). Extensive preclinical and clinical studies have shed light on the potential of stem cell replacement therapy for various neurodegenerative diseases. The key prerequisite for the success of these clinical applications is the procurement of a sufficient number of high-quality NSPCs. In this study, we explored the biological activity of Quadrella incana leaf in NSPC homeostasis. We showed that the leaf extract of Quadrella incana upregulated NSPC marker and proliferative potential. On the other hand, Quadrella incana leaf suppressed spontaneous unintended NSPC differentiation. Mechanistically, Quadrella incana leaf contributed to the maintenance of NSPCs by upregulating glycolytic flux and redox potential. | Kang, Mingyu; Cho, Jin-Hwa; Kim, Tae-Jun; Lee, Sang Min; Kim, Hyeon Ji; Coronado, Indiana; Yi, Dong-Keun; Kim, Do-Yeon | Kyungpook Natl Univ, Sch Dent, Dept Pharmacol, Daegu 41940, South Korea; Natl Univ Autonomous Nicaragua Leon, Herbarium HULE, Leon 68, Nicaragua; Korea Res Inst Biosci & Biotechnol, Int Biol Mat Res Ctr, Daejeon 34141, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Sch Dent, Dept Pharmacol, Daegu 41940, South Korea | ; Kim, Do-Yeon/AET-3021-2022; Kim, Yong-Tae/HQZ-0240-2023; Kim, Hee/AAU-6368-2021 | 57204540968; 24167566000; 57200911346; 57213176293; 57216816929; 15758943600; 35726304700; 57203012542 | alsrb5788@naver.com;cjinhwa@knu.ac.kr;toy5988@naver.com;leeyang2324@naver.com;guswl1634@naver.com;indiana.6coronado@gmail.com;lydian78@kribb.re.kr;dykim82@knu.ac.kr; | OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | OXID MED CELL LONGEV | 1942-0900 | 1942-0994 | 2020 | SCIE | CELL BIOLOGY | 2020 | 6.543 | 27.4 | 0 | 2025-06-25 | 1 | 0 | NEWBORN NEURONS; SELF-RENEWAL; STEM-CELLS; DIFFERENTIATION; TRANSPLANTATION; PATHWAYS; BALANCE | Cells; Cytology; Differentiation; Light; Maintenance; Redox Potential; Redox Reactions; Replacement; Animals; Capparaceae; Cell Differentiation; Cell Proliferation; Glycolysis; Homeostasis; Lactic Acid; Mice; Neural Stem Cells; Oxidation-Reduction; Oxidative Stress; Plant Extracts; Plant Leaves; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Up-Regulation; Bioactivity; Cytology; Disease control; Neurodegenerative diseases; Redox reactions; beta tubulin; beta2 tubulin; BMI1 protein; cell protein; fubp1 protein; glucose transporter 1; glucose transporter 3; glutathione; glutathione disulfide; hexokinase 1; histone H3; hk2 protein; lactate dehydrogenase A; lactic acid; mammalian target of rapamycin; messenger RNA; peroxiredoxin 3; phytochemical; pkm1 protein; plant extract; protein kinase B; Quadrella incana extract; reactive oxygen metabolite; transcription factor FKHR; transcription factor FKHRL1; transcription factor Sox2; unclassified drug; lactic acid; plant extract; protein kinase B; target of rapamycin kinase; Central nervous systems; Clinical application; Clinical study; Glycolytic flux; Leaf extracts; Multipotent cells; Neural stem/progenitor cells; Redox potentials; animal cell; Article; Capparaceae; cell differentiation; cell proliferation; controlled study; down regulation; drug isolation; glycolysis; mouse; mouse embryonic stem cell; mRNA expression level; multipotent stem cell; neural stem cell; nonhuman; oxidation reduction potential; oxidative stress; phytochemistry; plant leaf; protein expression level; Quadrella incana; signal transduction; stem cell self-renewal; upregulation; animal; Capparaceae; cell proliferation; chemistry; cytology; drug effect; homeostasis; metabolism; neural stem cell; oxidation reduction reaction; plant leaf; Stem cells | English | 2020 | 2020-04-27 | 10.1155/2020/5963037 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Synergy between Florfenicol and Aminoglycosides against Multidrug-Resistant Escherichia coli Isolates from Livestock | The increasing prevalence of antimicrobial resistance and the laborious development of novel antimicrobial agents have limited the options for effective antimicrobial therapy. The combination of previously used antimicrobial agents represents an alternative therapy for multidrug-resistant (MDR) pathogens. The objective of this study was to investigate the synergistic effect of a florfenicol (FFL)-based combination with other antimicrobial agents against MDR Escherichia coli isolates from livestock using checkerboard assays and murine infection models. The FFL/amikacin (AMK) and FFL/gentamicin (GEN) combinations showed synergy against 10/11 and 6/11 MDR E. coli isolates in vitro, respectively. The combination of FFL with aminoglycosides (AMK or GEN) exhibited a better synergistic effect against MDR E. coli isolates than the cephalothin (CEF)/GEN or FFL/CEF combinations. The combination of FFL with AMK or GEN could reduce the emergence of resistant mutants in vitro. The FFL/AMK combination showed a higher survival rate of mice infected with MDR E. coli isolates than FFL or AMK alone. In summary, the combination of FFL with aminoglycosides (AMK or GEN) is highly effective against MDR E. coli isolates both in vitro and in vivo. Our findings may contribute to the discovery of an effective combination regimen against MDR E. coli infections in veterinary medicine. | Kim, Shukho; Woo, Jung Hwa; Jun, So Hyun; Moon, Dong Chan; Lim, Suk-Kyung; Lee, Je Chul | Kyungpook Natl Univ, Sch Med, Dept Microbiol, Daegu 41944, South Korea; Anim & Plant Quarantine Agcy, Bacterial Dis Div, Gimcheon Si 39660, Gyeongsangbuk D, South Korea | ; Kim, Shukho/AGG-1087-2022 | 24341187900; 57211502461; 55181641700; 56657095700; 35086548900; 25930392000 | shukhokim@knu.ac.kr;dasomi999@naver.com;kkk016@nate.com;ansehdcks@korea.kr;imsk0049@korea.kr;leejc@knu.ac.kr; | ANTIBIOTICS-BASEL | ANTIBIOTICS-BASEL | 2079-6382 | 9 | 4 | SCIE | INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY | 2020 | 4.639 | 27.4 | 0.7 | 2025-06-25 | 7 | 11 | antimicrobial agent; combination therapy; synergy; florfenicol; aminoglycosides | COMBINATION; PHARMACOKINETICS; GENTAMICIN | Aminoglycosides; Antimicrobial agent; Combination therapy; Florfenicol; Synergy | amikacin; aminoglycoside; antiinfective agent; ceftiofur; chloramphenicol; ciprofloxacin; clavulanic acid; cotrimoxazole; extended spectrum beta lactamase; florfenicol; gentamicin; kanamycin; nalidixic acid; sulfamethoxazole; trimethoprim; animal experiment; antibiotic resistance; antibiotic sensitivity; Article; bacterial strain; bacterial virulence; bacterium isolate; broth dilution; controlled study; female; gene mutation; in vitro study; livestock; mouse; multidrug resistant Escherichia coli; nonhuman; priority journal; synergistic effect | English | 2020 | 2020-04 | 10.3390/antibiotics9040185 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Suppression of cathepsin a inhibits growth, migration, and invasion by inhibiting the p38 MAPK signaling pathway in prostate cancer | Prostate cancer has the highest incidence among men in advanced countries, as well as a high mortality rate. Despite the efforts of numerous researchers to identify a gene-based therapeutic target as an effective treatment of prostate cancer, there is still a need for further research. The cathepsin gene family is known to have a close correlation with various cancer types and is highly expressed across these cancer types. This study aimed at investigating the correlation between the cathepsin A (CTSA) gene and prostate cancer. Our findings indicated a significantly elevated level of CTSA gene expression in the tissues of patients with prostate cancer when compared with normal prostate tissues. Furthermore, the knockdown of the CTSA gene in the representative prostate cancer cell lines PC3 and DU145 led to reduced proliferation and a marked reduction in anchorage-independent colony formation, which was shown to be caused by cell cycle arrest in the S phase. In addition, CTSA gene-knockdown prostate cancer cell lines showed a substantial decrease in migration and invasion, as well as a decrease in the marker genes that promote epithelial mesenchymal transition (EMT). Such phenotypic changes in prostate cancer cell lines through CTSA gene suppression were found to be mainly caused by reduced p38 MAPK protein phosphorylation; i.e. the inactivation of the p38 MAPK cell signaling pathway. Tumorigenesis was also found to be inhibited in CTSA gene-knockdown prostate cancer cell lines when a xenograft assay was carried out using Balb/c nude mice, and the p38 MAPK phosphorylation was inhibited in tumor tissues. Thus, the CTSA gene is presumed to play a key role in human prostate cancer tissues through high-level expression, and the suppression of the CTSA gene leads to the inhibition of prostate cancer cell proliferation, colony formation, and metastasis. The mechanism, by which these effects occur, was demonstrated to be the inactivation of the p38 MAPK signaling pathway. | Park, Song; Kwon, Wookbong; Park, Jin-Kyu; Baek, Su-Min; Lee, Seoung-Woo; Cho, Gil-Jae; Ha, Yun-Sok; Lee, Jun Nyung; Kwon, Tae Gyun; Kim, Myoung Ok; Ryoo, Zae Young; Han, Se-Hyeon; Han, Jee Eun; Choi, Seong-Kyoon | DGIST, Div Biotechnol, Daegu, South Korea; DGIST, Dept Brain & Cognit Sci, Daegu, South Korea; DGIST, Core Prot Resources Ctr, Daegu, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 Plus KNU Creat Biores Grp, Daegu, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Hanyang Univ, Sch Media Commun, Wangsibri Ro 222, Seoul, South Korea; Dept News Team, SBS Seoul Broadcasting Stn, Mokdongseo Ro 161, Seoul, South Korea; Kyungpook Natl Univ, Sch Anim BT Sci, Sangju Si 37224, Gyeongsangbuk D, South Korea; Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu, South Korea | ; RYOO, ZAEYOUNG/AAQ-1573-2020 | 57139047900; 57139843600; 35213723500; 57207938426; 57218827581; 7201438083; 35487226400; 16301364600; 15073765400; 8934745900; 16937104900; 57210915063; 57214671240; 55505432500 | jehan@knu.ac.kr;cskbest@dgist.ac.kr; | ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | ARCH BIOCHEM BIOPHYS | 0003-9861 | 1096-0384 | 688 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOPHYSICS | 2020 | 4.013 | 27.5 | 1.18 | 2025-06-25 | 32 | 31 | Cathepsin A; Prostate cancer; Cell cycle; Metastasis; p38 MAPK | EPITHELIAL-MESENCHYMAL TRANSITION; EXPRESSION; PROLIFERATION; METASTASIS; PROGRESSION; ACTIVATION; PROTEASES; KINASES | Cathepsin A; Cell cycle; Metastasis; p38 MAPK; Prostate cancer | Animals; Base Sequence; Cathepsin A; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Knockdown Techniques; Humans; Male; Mice, Inbred BALB C; Neoplasm Metastasis; p38 Mitogen-Activated Protein Kinases; Prostate; Prostatic Neoplasms; Signal Transduction; activating transcription factor 2; carboxypeptidase C; cyclin B1; cyclin dependent kinase 2; mitogen activated protein kinase 1; mitogen activated protein kinase 14; mitogen activated protein kinase 3; mitogen activated protein kinase kinase 3; mitogen activated protein kinase kinase 6; stress activated protein kinase; transcription factor Slug; transcription factor Snail; transcription factor ZEB1; Twist related protein 1; carboxypeptidase C; CTSA protein, human; mitogen activated protein kinase p38; 22Rv1 cell line; animal experiment; animal model; Article; cancer patient; cancer tissue; cell cycle arrest; cell cycle S phase; cell growth; cell invasion; cell migration; cell proliferation; colony formation; controlled study; DU145 cell line; epithelial mesenchymal transition; gene expression; gene knockdown; gene repression; human; human cell; human tissue; immunohistochemistry; in vitro study; male; MAPK signaling; marker gene; mouse; nonhuman; phenotype; priority journal; prostate cancer; prostate tissue; protein expression; protein phosphorylation; RWPE-1 cell line; S phase cell cycle checkpoint; survival rate; tumor xenograft; Western blotting; animal; Bagg albino mouse; cell motion; genetics; metabolism; metastasis; nucleotide sequence; pathology; pathophysiology; physiology; prostate; prostate tumor; signal transduction; tumor cell line | English | 2020 | 2020-07-30 | 10.1016/j.abb.2020.108407 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Toluene Inhalation Causes Early Anxiety and Delayed Depression with Regulation of Dopamine Turnover, 5-HT1A Receptor, and Adult Neurogenesis in Mice | Inhaled solvents such as toluene are of particular concern due to their abuse potential that is easily exposed to the environment. The inhalation of toluene causes various behavioral problems, but, the effect of short-term exposure of toluene on changes in emotional behaviors over time after exposure and the accompanying pathological characteristics have not been fully identified. Here, we evaluated the behavioral and neurochemical changes observed over time in mice that inhaled toluene. The mice were exposed to toluene for 30 min at a concentration of either 500 or 2,000 ppm. Toluene did not cause social or motor dysfunction in mice. However, increased anxiety-like behavior was detected in the short-term after exposure, and depression-like behavior appeared as delayed effects. The amount of striatal dopamine metabolites was significantly decreased by toluene, which continued to be seen for up to almost two weeks after inhalation. Additionally, an upregulation of serotonin 1A (5-HT1A) receptor in the hippocampus and the substantia nigra, as well as reduced immunoreactivity of neurogenesis markers in the dentate gyrus, was observed in the mice after two weeks. These results suggest that toluene inhalation, even single exposure, mimics early anxiety-and delayed depression-like emotional disturbances, underpinned by pathological changes in the brain. | Kim, Jinhee; Lim, Juhee; Moon, Seong-Hee; Liu, Kwang-Hyeon; Choi, Hyun Jin | CHA Univ, Coll Pharm, Seongnam 13488, South Korea; CHA Univ, Inst Pharmaceut Sci, Seongnam 13488, South Korea; Kyungpook Natl Univ, Coll Pharm, BK21 Plus KNU Multiom Based Creat Drug Res Team, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu 41566, South Korea | Choi, Hyun/Y-7144-2018 | 58382024000; 24166710700; 57216882946; 55768214700; 58817298500 | dstlkh@knu.ac.kr;hjchoi3@cha.ac.kr; | BIOMOLECULES & THERAPEUTICS | BIOMOL THER | 1976-9148 | 2005-4483 | 28 | 3 | SCIE | PHARMACOLOGY & PHARMACY | 2020 | 4.634 | 27.7 | 0.86 | 2025-06-25 | 14 | 16 | Anxiety; Depression; Dopamine; Neurogenesis; Serotonin 5-HT1A receptor; Toluene | DENTATE GYRUS; EXPOSURE; SEROTONIN; ADOLESCENT; BEHAVIOR; HIPPOCAMPUS; SENSITIVITY; INCREASE; DEFICITS; NUCLEUS | Anxiety; Depression; Dopamine; Neurogenesis; Serotonin 5-HT<sub>1A</sub> receptor; Toluene | antidepressant agent; dopamine; serotonin 1A receptor; toluene; animal experiment; animal model; animal tissue; antidepressant activity; anxiety disorder; Article; behavior assessment; brain cortex; chemoluminescence; circadian rhythm; controlled study; cytotoxicity; dentate gyrus; depression; dorsal striatum; electrochemical analysis; elevated plus maze test; experimental behavioral test; forced swim test; high performance liquid chromatography; hippocampus; immobility time; immunoprecipitation; immunoreactivity; male; Morris water maze test; mouse; nervous system development; nonhuman; novel object recognition test; passive avoidance test; protein expression; rotarod test; social interaction; social interaction test; substantia nigra; tail suspension test; upregulation; Western blotting | English | 2020 | 2020-05 | 10.4062/biomolther.2020.055 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | β-Amyrin Ameliorates Alzheimer's Disease-Like Aberrant Synaptic Plasticity in the Mouse Hippocampus | Alzheimer's disease (AD) is a progressive and most frequently diagnosed neurodegenerative disorder. However, there is still no drug preventing the progress of this disorder. beta-Amyrin, an ingredient of the surface wax of tomato fruit and dandelion coffee, is previously reported to ameliorate memory impairment induced by cholinergic dysfunction. Therefore, we tested whether beta-amyrin can prevent AD-like pathology. beta-Amyrin blocked amyloid beta (A beta)-induced long-term potentiation (LTP) impairment in the hippocampal slices. Moreover, beta-amyrin improved A beta-induced suppression of phosphatidylinositol-3-kinase (PI3K)/Akt signaling. LY294002, a PI3K inhibitor, blocked the effect of li-amyrin on A beta-induced LTP impairment. In in vivo experiments, we observed that beta-amyrin ameliorated object recognition memory deficit in A beta-injected AD mice model. Moreover, neurogenesis impairments induced by A beta was improved by beta-amyrin treatment. Taken together, beta-amyrin might be a good candidate of treatment or supplement for AD patients. | Park, Hye Jin; Kwon, Huiyoung; Lee, Ji Hye; Cho, Eunbi; Lee, Young Choon; Moon, Minho; Jun, Mira; Kim, Dong Hyun; Jung, Ji Wook | Dong A Univ, Dept Med Biotechnol, Coll Hlth Sci, Busan 49315, South Korea; Kyungpook Natl Univ, Div Endocrinol, Sch Med, Daegu 41944, South Korea; Dong A Univ, Inst Convergence BioHlth, Busan 49315, South Korea; Konyang Univ, Dept Biochem, Coll Med, Daejeon 35365, South Korea; Dong A Univ, Coll Hlth Sci, Dept Food Sci & Nutr, Busan 49315, South Korea; Daegu Haany Univ, Coll Herbal Bioind, Dept Herbal Med Pharmacol, Kyungsan 38610, South Korea | Kim, Dong Hyun/AEC-4494-2022; Lee, Sangyeop/M-8307-2017 | 56477581700; 57195999296; 57269039200; 57202281620; 36067817200; 57199644732; 16230761800; 57222647956; 57199983943 | mose79@dau.ac.kr;jwjung@dhu.ac.kr; | BIOMOLECULES & THERAPEUTICS | BIOMOL THER | 1976-9148 | 2005-4483 | 28 | 1 | SCIE | PHARMACOLOGY & PHARMACY | 2020 | 4.634 | 27.7 | 1.1 | 2025-06-25 | 23 | 23 | beta-amyrin; Amyloid beta; Alzheimer's disease; Synaptic plasticity | LONG-TERM POTENTIATION; PENTACYCLIC TRITERPENE; SIGNALING PATHWAY; NEUROGENESIS; MEMORY; MODELS; LTP; DYSFUNCTIONS; ACTIVATION; IMPAIRMENT | Alzheimer’s disease; Amyloid β; Synaptic plasticity; β-amyrin | 2 morpholino 8 phenylchromone; beta amyrin; doublecortin; Ki 67 antigen; minocycline; mitogen activated protein kinase inhibitor; u 0125; unclassified drug; Alzheimer disease; animal experiment; animal model; animal tissue; Article; cerebrospinal fluid; cholinergic activity; electric potential; habituation; hippocampus; immunohistochemistry; male; memory disorder; mouse; nerve cell plasticity; nerve cell stimulation; nervous system development; nonhuman; novel object recognition test; passive avoidance test; Pi3K/Akt signaling; protein phosphorylation; upregulation; Western blotting | English | 2020 | 2020-01 | 10.4062/biomolther.2019.024 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Nurses' Experiences with Disclosure of Patient Safety Incidents: A Qualitative Study | Background: Patient safety incidents trigger conflict between healthcare providers and patients. Patients and families want to hear detailed explanations and apologies from medical staff, but nurses may face difficulties with disclosure of patient safety incidents. Purpose: To identify nurses' experiences with disclosure of patient safety incidents. Methods: Data were collected through in-depth interviews with nine clinical and five head nurses and were analyzed using Colaizzi's phenomenological method. Findings: After formulating 18 themes representing nurses' experiences with disclosure of patient safety incidents, we clustered them into four theme clusters: "mixed responses from patients and families," "caught in a swirl of negative emotions," "facing the reality that hinders disclosure," and "waiting for a breakthrough that would enable disclosure". Conclusion: Policies, systems, and culture that help both patients and healthcare professionals should be developed. | Kim, Yujeong; Lee, Haeyoung | Kyungpook Natl Univ, Coll Nursing, Res Inst Nursing Sci, Daegu 41944, South Korea; Chung Ang Univ, Red Cross Coll Nursing, Seoul 06974, South Korea | ; Lee, Haeyoung/NRA-8461-2025 | 57200941945; 57205471062 | im0202@cau.ac.kr; | RISK MANAGEMENT AND HEALTHCARE POLICY | RISK MANAG HEALTHC P | 1179-1594 | 13 | SCIE;SSCI | HEALTH CARE SCIENCES & SERVICES;HEALTH POLICY & SERVICES | 2020 | 3.2 | 27.8 | 0.78 | 2025-06-25 | 13 | 15 | disclosure; medical errors; nurses; patient safety; qualitative research | MEDICAL ERRORS; PHYSICIANS ATTITUDES; CARE; PERSPECTIVES; PERCEPTIONS; VIEWS | Disclosure; Medical errors; Nurses; Patient safety; Qualitative research | adult; article; drug safety; head nurse; human; interview; medical error; patient safety; qualitative research | English | 2020 | 2020 | 10.2147/rmhp.s253399 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Time varying integration of European stock markets and monetary drivers | This study analyzes time-varying integration of stock markets among fourteen European countries and its monetary drivers relevant to the two contrasting events - the introduction of Euro in 1999 and banking crisis of GHPS in 2011. Our panel analysis reports evidence that monetary performance convergence, lower differentials in interest rates and inflation among EU countries, has been a key driver for the increase in integration of EU stock markets post EMU. Our qualitative analysis indicates that post EMU, the GDP differences among the EU countries have reverse relations with monetary performance convergence. This finding is in line with those of our quantitative study with a price-based indicator for integration. | Lee, Hyunchul; Kim, Heeho | Chosun Univ, Div Business Adm, Gwang Ju, South Korea; London Sch Econ & Polit Sci, Dept Econ Hist, London, England; Kyungpook Natl Univ, Sch Econ, Daegu, South Korea | Kim, Heeho/AAO-8809-2021 | 55706798700; 36727893700 | chul72@chosun.ac.kr; | JOURNAL OF EMPIRICAL FINANCE | J EMPIR FINANC | 0927-5398 | 1879-1727 | 58 | SSCI | BUSINESS, FINANCE;ECONOMICS | 2020 | 2.779 | 27.8 | 0.69 | 2025-06-25 | 11 | 11 | Stock market integration; Realized correlation; EMU; Monetary performance convergence | FINANCIAL DEVELOPMENT; VOLATILITY; UNION; SPECIFICATION; DETERMINANTS; TESTS; EMU | EMU; Monetary performance convergence; Realized correlation; Stock market integration | English | 2020 | 2020-09 | 10.1016/j.jempfin.2020.07.004 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Electronic Cigarette Themes on Twitter: Dissemination Patterns and Relations with Online News and Search Engine Queries in South Korea | This study examines multiple aspects of e-cigarette mentions on different online media channels during the announcement and implementation of a cigarette tax increase policy in South Korea. It consists of three parts. First, a Naive Bayes classifier was used to sort 59,147 tweets about e-cigarettes into five pre-designated themes - promotion, health, policy, product evaluation, and price - and to determine their relative prevalence. Second, social network analysis was used to identify the themes' dissemination patterns. Third, the themes were examined for their associations with e-cigarette mentions in two other media channels - online news articles (n = 580) and search engine queries (64 weeks of Google Trends data). Results show that the most prevalent tweet theme was product evaluation, and the theme with the largest increase during the data collection period was promotion. Promotion-themed tweets were the least connected with tweets about the other five themes, while health-themed tweets were the most connected. Finally, product evaluation-themed tweets exhibited the strongest correlation with search engine query count and had the largest explanatory power. | Paek, Hye-Jin; Baek, Hyunmi; Lee, Saerom; Hove, Thomas | Hanyang Univ, Dept Advertising & Publ Relat, Seoul, South Korea; Korea Univ, Sch Media & Commun, 145 Anam Ro, Seoul 02841, South Korea; Kyungpook Natl Univ, Sch Business Adm, Daegu, South Korea | Baek, Hye/T-2076-2019 | 10642131000; 57543501600; 56023428700; 15757311200 | lotus1225@korea.ac.kr; | HEALTH COMMUNICATION | HEALTH COMMUN | 1041-0236 | 1532-7027 | 35 | 1 | SSCI | COMMUNICATION;HEALTH POLICY & SERVICES | 2020 | 3.198 | 27.9 | 0.6 | 2025-06-25 | 7 | 7 | WORD-OF-MOUTH; MEDIA; SMOKING; TWEETS; SALES; US | Data Collection; Electronic Nicotine Delivery Systems; Humans; Information Dissemination; Marketing; Public Policy; Republic of Korea; Search Engine; Social Media; Social Network Analysis; electronic cigarette; human; information dissemination; information processing; marketing; public policy; search engine; social media; South Korea | English | 2020 | 2020-01-02 | 10.1080/10410236.2018.1536952 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Non-intrusive detection of gas-water interface in circular pipes inclined at various angles | A new method for detecting a gas water interface in a circular pipe is proposed. In the method, ultrasonic signals are used for non-intrusive measurement and three types of signal analyses are conducted: time of-flight (TOF), local amplitude, and global amplitude analyses. Horizontal, 45 inclined, and vertical pipe configurations were used to verify the applicability of the proposed detection method. In the case of a horizontal pipe with an acoustic beam directed perpendicular to the water surface, TOF and amplitude analyses detect the water level. In the cases of a horizontal pipe with an acoustic beam directed parallel to the water surface, a 45 inclined pipe, and a vertical pipe, when the pipes were filled with water. TOF analysis was not applicable and amplitude analysis detects the water level. In conclusion, the gas liquid interface in circular pipes could be analyzed qualitatively and quantitatively through the proposed non intrusive acoustic method. (C) 2019 Elsevier Ltd. All rights reserved. | Jo, Hongrae; Song, Yong Jae; Jo, Daeseong | Kyungpook Natl Univ, Sch Mech Engn, 80 Daehak Ro, Daegu 41566, South Korea; FNC Technol Co Ltd, 44 Tapsil Ro, Yongin 17084, Gyeonggi Do, South Korea | 57194614170; 57203764343; 16424303000 | djo@knu.ac.kr; | ANNALS OF NUCLEAR ENERGY | ANN NUCL ENERGY | 0306-4549 | 139 | SCIE | NUCLEAR SCIENCE & TECHNOLOGY | 2020 | 1.776 | 27.9 | 0.21 | 2025-06-25 | 2 | 3 | Non-intrusive detection; Gas-water interface; Acoustic analysis; Gas accumulation | THICKNESS MEASUREMENT | Acoustic analysis; Gas accumulation; Gas-water interface; Non-intrusive detection | Acoustic waves; Acoustics; Gases; Ultrasonic applications; Water levels; Acoustic analysis; Amplitude analysis; Detection methods; Gas accumulation; Gas-water interface; Non-intrusive; Non-intrusive measurements; Ultrasonic signals; Phase interfaces | English | 2020 | 2020-05 | 10.1016/j.anucene.2019.107267 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | A Synthesis Inversion to Constrain Global Emissions of Two Very Short Lived Chlorocarbons: Dichloromethane, and Perchloroethylene | Dichloromethane (CH2Cl2) and perchloroethylene (C2Cl4) are chlorinated very short lived substances (Cl-VSLS) with anthropogenic sources. Recent studies highlight the increasing influence of such compounds, particularly CH2Cl2, on the stratospheric chlorine budget and therefore on ozone depletion. Here, a multiyear global-scale synthesis inversion was performed to optimize CH2Cl2(2006-2017) and C2Cl4(2007-2017) emissions. The approach combines long-term surface observations from global monitoring networks, output from a three-dimensional chemical transport model (TOMCAT), and novel bottom-up information on prior industry emissions. Our posterior results show an increase in global CH(2)Cl(2)emissions from 637 +/- 36 Gg yr(-1)in 2006 to 1,171 +/- 45 Gg yr(-1)in 2017, with Asian emissions accounting for 68% and 89% of these totals, respectively. In absolute terms, Asian CH(2)Cl(2)emissions increased annually by 51 Gg yr(-1)over the study period, while European and North American emissions declined, indicating a continental-scale shift in emission distribution since the mid-2000s. For C2Cl4, we estimate a decrease in global emissions from 141 +/- 14 Gg yr(-1)in 2007 to 106 +/- 12 Gg yr(-1)in 2017. The time-varying posterior emissions offer significant improvements over the prior. Utilizing the posterior emissions leads to modeled tropospheric CH(2)Cl(2)and C(2)Cl(4)abundances and trends in good agreement to those observed (including independent observations to the inversion). A shorter C(2)Cl(4)lifetime, from including an uncertain Cl sink, leads to larger global C(2)Cl(4)emissions by a factor of similar to 1.5, which in some places improves model-measurement agreement. The sensitivity of our findings to assumptions in the inversion procedure, including CH(2)Cl(2)oceanic emissions, is discussed. Plain Language Summary The 1987 Montreal Protocol banned production for dispersive uses of major ozone-depleting gases, such as chlorofluorocarbons, due to their role in depletion of the stratospheric ozone layer. In consequence, the ozone layer is expected to recover in coming decades, as stratospheric chlorine from banned substances slowly declines. However, chlorinated very short lived substances (Cl-VSLS), not controlled by the Montreal Protocol, represent a small, but growing, source of atmospheric chlorine that could potentially slow ozone recovery. It is thus important that the magnitude of emissions of these compounds, their spatial distribution, and changes with time are quantified. Here, we combined observations of Cl-VSLS, prior estimates of their emissions, and a chemical transport model to produce an optimized set of emission estimates on a region-by-region basis between 2006 and 2017. We show that industrial emissions of dichloromethane, the most abundant Cl-VSLS, increased by similar to 84% within this period, predominately due to an increase in Asian emissions, while European and North American emissions decreased. Over 2007-2017, emissions of perchloroethylene, a less abundant Cl-VSLS, decreased, particularly in Europe and North America. We show that our new emission estimates lead to better agreement with observational data compared to previous estimates. | Claxton, Tom; Hossaini, Ryan; Wilson, Chris; Montzka, Stephen A.; Chipperfield, Martyn P.; Wild, Oliver; Bednarz, Ewa M.; Carpenter, Lucy J.; Andrews, Stephen J.; Hackenberg, Sina C.; Muhle, Jens; Oram, David; Park, Sunyoung; Park, Mi-Kyung; Atlas, Elliot; Navarro, Maria; Schauffler, Sue; Sherry, David; Vollmer, Martin; Schuck, Tanja; Engel, Andreas; Krummel, Paul B.; Maione, Michela; Arduini, Jgor; Saito, Takuya; Yokouchi, Yoko; O'Doherty, Simon; Young, Dickon; Lunder, Chris | Univ Lancaster, Lancaster Environm Ctr, Lancaster, England; Univ Leeds, Sch Earth & Environm, Leeds, W Yorkshire, England; Univ Leeds, Natl Ctr Earth Observat, Leeds, W Yorkshire, England; NOAA, Boulder, CO USA; Univ York, Dept Chem, Wolfson Atmospher Chem Labs, York, N Yorkshire, England; Univ Calif San Diego, Scripps Inst Oceanog, San Diego, CA 92103 USA; Univ East Anglia, Sch Environm Sci, Natl Ctr Atmospher Sci, Norwich, Norfolk, England; Kyungpook Natl Univ, Kyungpook Inst Oceanog, Daegu, South Korea; Univ Miami, Rosenstiel Sch Marine & Atmospher Sci, 4600 Rickenbacker Causeway, Miami, FL 33149 USA; Natl Ctr Atmospher Res, POB 3000, Boulder, CO 80307 USA; Nolan Sherry & Associates, London, England; Empa, Swiss Fed Labs Mat Sci & Technol, Lab Air Pollut & Environm Technol, Dubendorf, Switzerland; Goethe Univ Frankfurt, Inst Atmospher & Environm Sci, Frankfurt, Germany; CSIRO Oceans & Atmosphere, Climate Sci Ctr, Aspendale, Vic, Australia; Univ Urbino, Dept Pure & Appl Sci, Urbino, Italy; Natl Inst Environm Studies, Tsukuba, Ibaraki, Japan; Univ Bristol, Sch Chem, Bristol, Avon, England; Norwegian Inst Air Res, Kjeller, Norway; Eurofins Dr Specht Int GmbH, Neulander Gewerbepk 2, Hamburg, Germany | ; Schuck, Tanja/F-2941-2010; Chipperfield, Martyn/H-6359-2013; Krummel, Paul/A-4293-2013; Muhle, Jens/GPX-3244-2022; montzka, stephen/V-6162-2019; Hossaini, Ryan/F-7134-2015; arduini, jgor/N-2798-2016; Wild, Oliver/A-4909-2009; Wilson, Chris/AGL-9477-2022; Carpenter, Lucy/E-6742-2013; Young, Dickon/AFO-7065-2022; Engel, Andreas/E-3100-2014; Atlas, Elliot/AAE-4605-2021; Park, Mi-Kyung/J-9643-2017 | 57208885380; 35364271200; 57200952551; 6603786703; 7004402705; 6701636816; 57191369528; 7102689176; 55520327700; 56613191200; 55917306500; 7005733107; 57085459500; 7404491155; 16206263100; 55960205400; 6603689569; 57196045736; 56668474200; 8623052000; 57218945689; 6602579613; 7005182425; 7801467546; 55628558157; 7004855166; 6603729725; 22837436400; 15835085000 | t.claxton@lancaster.ac.uk;r.hossaini@lancaster.ac.uk; | JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES | J GEOPHYS RES-ATMOS | 2169-897X | 2169-8996 | 125 | 12 | SCIE | METEOROLOGY & ATMOSPHERIC SCIENCES | 2020 | 4.261 | 28.2 | 1.23 | 2025-06-25 | 31 | 29 | vsls</AUTHOR_KEYWORD>; inversion</AUTHOR_KEYWORD>; emissions</AUTHOR_KEYWORD>; dichloromethane</AUTHOR_KEYWORD>; perchloroethylene</AUTHOR_KEYWORD>; montreal protocol</AUTHOR_KEYWORD> | CHLORINE EMISSIONS; REACTIVE CHLORINE; TRANSPORT MODEL; TETRACHLOROETHENE; VARIABILITY; BROMOFORM; BROMINE; GASES; AIR; TRICHLOROETHENE | dichloromethane; emissions; inversion; montreal protocol; perchloroethylene; vsls | air quality; atmospheric chemistry; atmospheric pollution; atmospheric transport; carbon emission; chlorinated hydrocarbon; ethane; industrial emission; methane; ozone; three-dimensional modeling; trend analysis | English | 2020 | 2020-06-27 | 10.1029/2019jd031818 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Performance Evaluation of CMIP5 and CMIP6 Models on Heatwaves in Korea and Associated Teleconnection Patterns | This study assesses the performance of the Coupled Model Intercomparison Project (CMIP) models for simulating summer heatwaves in Korea during a historical simulation period (1979-2014) using four diagnostic indices that represent the teleconnection mechanism of summer heatwaves in Korea. Four skill metrics are used for the model evaluation, namely, relative error (RE), interannual variability skill-score (IVS), correlation coefficient (CC), and total ranking (TR) based on daily maximum temperature (TMAX) in Korea and the four diagnostic indices. The results show that the REs of CMIP5 models do not differ significantly from those of the CMIP6 models while the IVSs in the CMIP6 models are significantly improved compared with the CMIP5 models. Observations show that the heatwave circulation index (HWCI) contributes more to the interannual variability in TMAX in Korea than that of the Indian Monsoon Rainfall Index (IMRI), indicating that the teleconnection from the northwestern Pacific is more important than that from northwestern India. Interestingly, the CMIP6 models simulate this property better than the CMIP5 ensemble. The higher TR of CMIP6 models than CMIP5 supports that CMIP6 models are better overall in simulating heatwaves in Korea and the associated diagnostic indices. | Kim, Maeng-Ki; Yu, Dae-Geun; Oh, Ji-Seon; Byun, Young-Hwa; Boo, Kyung-On; Chung, Il-Ung; Park, Jeong-Soo; Park, Doo-Sun R.; Min, Seung-Ki; Sung, Hyun Min | Kongju Natl Univ, Dept Atmospher Sci, Gongju, South Korea; Natl Inst Meteorol Sci, Innovat Meteorol Res Dept, Seogwipo, South Korea; Gangneung Wonju Natl Univ, Dept Atmospher & Environm Sci, Gangneung Si, South Korea; Chonnam Natl Univ, Dept Stat, Gwangju, South Korea; Kyungpook Natl Univ, Dept Earth Sci Educ, Daegu, South Korea; Pohang Univ Sci & Technol POSTECH, Div Environm Sci & Engn, Pohang, South Korea | Byun, Young-Hwa/JCO-1048-2023; Park, Doo-Sun/U-9448-2019; Park, JeongSoo/LVR-8624-2024; Min, Seung-Ki/B-1431-2010; BYUN, Young-Hwa/JCO-1048-2023 | 7406091975; 57220788475; 57199948582; 34568038900; 7003459696; 7201868003; 35171145500; 37117659000; 57192273006; 57210809003 | mkkim@kongju.ac.kr; | JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES | J GEOPHYS RES-ATMOS | 2169-897X | 2169-8996 | 125 | 23 | SCIE | METEOROLOGY & ATMOSPHERIC SCIENCES | 2020 | 4.261 | 28.2 | 1.81 | 2025-06-25 | 28 | 30 | heatwave; Coupled Model Intercomparison Project 6; metrics; model performance; diagnostic index; Korea | HEAT-WAVE; CIRCUMGLOBAL TELECONNECTION; FUTURE PROJECTIONS; REGIONAL CLIMATE; PACIFIC-JAPAN; EAST-ASIA; SUMMER; IMPACT; PRECIPITATION; TEMPERATURE | Coupled Model Intercomparison Project 6; diagnostic index; heatwave; Korea; metrics; model performance | India; Korea; Pacific Ocean; Pacific Ocean (Northwest); annual variation; atmospheric circulation; climate modeling; CMIP; heat wave; monsoon; performance assessment; ranking; seasonality; teleconnection | English | 2020 | 2020-12-16 | 10.1029/2020jd032583 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Refractive Index for Asian Dust in the Ultraviolet - Visible Region Determined From Compositional Analysis 3 and Validated With OMI Observations | Asian dust aerosols consist of various minerals, such as quartz, clay minerals, feldspars, and calcite. Complex refractive index of Asian dust is determined for a spectral range from 0.2 to 1.0 mu m, assuming that the particles are an internal mixture of the component minerals in dust samples reported in previous literature. The derived optical constants for Asian dust are quite different from the refractive indices for other desert dusts. The imaginary refractive index for Asian dust is much smaller than that of the "mineral" model in Optical Properties of Aerosols and Clouds (OPAC) across the whole range. At wavelengths shorter than 650 nm, the present imaginary index is smaller than the index for Saharan dust, determined from mineralogical compositions of dust samples at Tinfou, Morocco, during the Saharan Mineral Dust Experiment (SAMUM). The simulated spectrum for an Asian dust event on 15 March 2009 in north-east China using the present optical constants agree well with the spectrum measured by the Ozone Monitoring Instrument (OMI) on board the Aura spacecraft. | Lee, Kwang-Mog; Choi, Haklim; Kim, Jhoon | Kyungpook Natl Univ, Dept Astron & Atmospher Sci, Daegu, South Korea; Yonsei Univ, Dept Atmospher Sci, Seoul, South Korea | Kim, Jhoon/F-6635-2013 | 35412373800; 57215186877; 9233714800 | kmlee@knu.ac.kr; | JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES | J GEOPHYS RES-ATMOS | 2169-897X | 2169-8996 | 125 | 4 | SCIE | METEOROLOGY & ATMOSPHERIC SCIENCES | 2020 | 4.261 | 28.2 | 0.16 | 2025-06-25 | 6 | 6 | ABSORPTION CROSS-SECTIONS; OZONE UV SPECTROSCOPY; SAHARAN-MINERAL-DUST; OPTICAL-CONSTANTS; TROPOSPHERIC AEROSOLS; RADIATIVE PROPERTIES; PARTICLES; SCATTERING; APPLICABILITY; COEFFICIENTS | Asian dust; dust minerals; OMI spectra; optical constants; refractive index | China; Draa-Tafilalet; Morocco; Tinfou; aerosol; dust; mineral; optical property; refractive index | English | 2020 | 2020-02-27 | 10.1029/2019jd030629 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | The small N=4 superconformal W∞ algebra | The symmetric orbifold of T-4 is the CFT dual of string theory on ADS(3) x S-3 x T-4 with minimal NS-NS flux. We study its symmetry algebra and provide evidence that it does not have any deformation parameter. This suggests that the symmetric orbifold is (at least locally) the most symmetrical CFT in its moduli space. | Ahn, Changhyun; Gaberdiel, Matthias R.; Kim, Man Hea | Kyungpook Natl Univ, Dept Phys, Taegu 41566, South Korea; Swiss Fed Inst Technol, Inst Theoret Phys, CH-8093 Zurich, Switzerland; Asia Pacific Ctr Theoret Phys, Pohang 37673, South Korea | ; KIM, MAN HEA/GNN-0026-2022 | 7201986707; 7004636079; 57190220753 | ahn@knu.ac.kr;gaberdiel@itp.phys.ethz.ch;manhea.kim@apctp.org; | JOURNAL OF PHYSICS A-MATHEMATICAL AND THEORETICAL | J PHYS A-MATH THEOR | 1751-8113 | 1751-8121 | 53 | 39 | SCIE | PHYSICS, MATHEMATICAL;PHYSICS, MULTIDISCIPLINARY | 2020 | 2.132 | 28.2 | 0.42 | 2025-06-25 | 6 | 6 | CFT; higher spin symmetry; AdS/CFT | HIGHER SPIN CURRENTS; STRINGS | AdS/CFT; CFT; higher spin symmetry | English | 2020 | 2020-10-02 | 10.1088/1751-8121/aba5ba | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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