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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Efficacy of soil drench and foliar application of iron nanoparticles on the growth and physiology of Solanum lycopersicum L. exposed to cadmium stress | Cadmium (Cd) can harm the yield and quality of vegetables, threatening food safety. Essential microelements such as iron are crucial for plant growth and can help alleviate heavy metal stress. Recently, nanoparticles have been studied as eco-friendly solutions for mitigating heavy metal stress in plants. In the present study, iron nanoparticles (FeNPs) at 0, 100, and 300 mg/L were applied as soil drenches and foliar sprays to tomato plants under cadmium stress. A comparison was made between the application methods of FeNPs by evaluating the growth parameters of tomato plants, including shoot length (SL), root length (RL), number of branches (NB), number of leaves per plant (NL), and leaf area (LA), as well as by assessing biochemical and antioxidant enzyme parameters. In the Cd stress treatment, the protein content decreased by 24.71%, and the phenolic and flavonoid content of the tomato plants also decreased due to cadmium stress, with levels decreasing from 16.07 to 6.9 mu g and from 0.36 to 0.16 mu g, respectively. Compared with the soil drench, 100 mg/L FeNPs significantly improved the parameters of Cd-stressed plants when used as a foliar spray, leading to increases in shoot length, root length, fruit weight, number of fruits, number of leaves, and number of branches by 42%, 66%, 24%, 66%, 173%, and 45%, respectively. Tomato plants treated with this spray presented increased carotenoid and lycopene contents. FeNP foliar spray also reduced Cd accumulation in plant tissues. This technique shows promise in alleviating Cd stress in vulnerable vegetable plants such as tomatoes. | Ahmad, Asma; Javad, Sumera; Iqbal, Sumera; Shahid, Tayyaba; Naz, Shagufta; Shah, Anis Ali; Shaffique, Shifa; Gatasheh, Mansour K. | Lahore Coll Women Univ, Dept Bot, Lahore, Pakistan; Lahore Coll Women Univ, Dept Biotechnol, Lahore, Pakistan; Univ Educ, Dept Bot, Div Sci & Technol, Lahore, Pakistan; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, 80 Daehak Ro, Daegu 41566, South Korea; King Saud Univ, Coll Sci, Dept Biochem, POB 2455, Riyadh 11451, Saudi Arabia | Shah, Dr. Anis/AAV-2232-2020; Gatasheh, Mansour/AAP-9414-2021; Javad, Sumera/ADB-7547-2022; shaffique, shifa/KUC-7102-2024 | 57219597553; 35344711200; 26023190000; 59412008400; 24544753800; 57211606140; 57203898867; 15742571400 | zif_4@yahoo.com;anisalibot@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 1.23 | 2025-05-07 | 5 | 6 | Antioxidant enzymes; Cadmium stress; Iron nanoparticles; Lycopene; Tomato plant (Solanum lycopersicum L.); Stress | INDUCED OXIDATIVE STRESS; OXIDE NANOPARTICLES; ANTIOXIDANT ENZYMES; PLANTS; PHOTOSYNTHESIS; SELENIUM; SATIVA; GREEN; ACCUMULATION; TOLERANCE | Antioxidant enzymes; Cadmium stress; Iron nanoparticles; Lycopene; Stress; Tomato plant (Solanum lycopersicum L.) | Antioxidants; Cadmium; Iron; Metal Nanoparticles; Plant Leaves; Plant Roots; Soil; Soil Pollutants; Solanum lycopersicum; Stress, Physiological; antioxidant; cadmium; iron; metal nanoparticle; chemistry; drug effect; growth, development and aging; metabolism; physiological stress; plant leaf; plant root; soil; soil pollutant; tomato; toxicity | English | 2024 | 2024-11-13 | 10.1038/s41598-024-79270-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Enhancing salt tolerance in rice genotypes through exogenous melatonin application by modulating growth patterns and antistress agents | Melatonin is a bioactive molecule with an important role in plants responding to various abiotic and biotic stresses. This study aims to determine the role of melatonin in rice under salt stress. This study used a factorial completely randomized design. The first factor was local rice varieties (IR64 and Silaun), and the second factor was plant treatments (control, 1 mu M melatonin, 150 mM NaCl, 150 mM NaCl + 1 mu M melatonin). This study shows that exogenous melatonin can increase plant growth, such as plant height, root length, stem length, leaf length, leaf area, and plant biomass under salt stress compared to treatment without melatonin. Exogenous melatonin can increase the total chlorophyll content, relative water content, and proline content, reduce the total sodium content, and increase potassium absorption under conditions of salinity stress. Melatonin is also able to scavenge ROS in plants, resulted the decrease in ROS and MDA content. In terms of gene expression, OsAPX1 and cytosolic APX exhibited the highest expression in IR64 under combined salt and melatonin treatment, while GPOD, Mn-SOD, and Cu/Zn-SOD were upregulated under various conditions in both varieties. Additionally, OsLEA showed high expression in both varieties under control conditions, and CAT was significantly upregulated under salt stress. Our findings indicate that exogenous melatonin has the potential to enhance various factors under salt stress and helping in the recovery of rice plants from sodium (Na+) damage. | Ubaidillah, Mohammad; Farooq, Muhammad; Kim, Kyung-Min | Univ Jember, Study program Agrotechnol, Fac Agr, JI Kalimantan,37 Kampus Tegal Boto, Jember, East Java, Indonesia; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea | Kim, Kyung-Min Kim/C-7007-2014; Ubaidillah, Mohammad/HRD-1784-2023 | 56011434400; 57215544380; 34868260300 | kkm@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 2.45 | 2025-05-07 | 6 | 6 | Salt stress; Antioxidant genes; Melatonin; Rice; Oxidative stress | ABIOTIC STRESS; PLANTS | Antioxidant genes; Melatonin; Oxidative stress; Rice; Salt stress | Chlorophyll; Gene Expression Regulation, Plant; Genotype; Melatonin; Oryza; Plant Leaves; Reactive Oxygen Species; Salt Stress; Salt Tolerance; Sodium; Stress, Physiological; chlorophyll; melatonin; reactive oxygen metabolite; sodium; drug effect; gene expression regulation; genetics; genotype; growth, development and aging; metabolism; Oryza; physiological stress; plant leaf; salt stress; salt tolerance | English | 2024 | 2024-10-24 | 10.1038/s41598-024-77161-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Evaluation of exhaust emissions of agricultural tractors using portable emissions measurement system in Korean paddy field | Recently, diesel engine emissions have been designated as a first-class carcinogen by the World Health Organization (WHO). As such, problems with diesel engine emissions continue to increase around the world. This study aimed to analyze the emissions (CO, NOx, PM) of agricultural tractors during farming operations in order to build a reliable national inventory of air pollutant emissions. Emission data were collected using a portable emission measurement system during actual agricultural operation. The load factor (LF) of the engine was calculated using the collected engine information, the emission factor was analyzed using the LF and the measured emission. The LF was significantly different from the current standard value of 0.48, which is used in Korea to calculate exhaust emissions. The deviation ratio of the emission factor was 0.039 similar to 56.59 compared to Tier-4 emission regulation standards. Under many conditions, the calculated emission factor was higher than the emission limit. Thus, this study provides useful information for emission inventory construction through emission calculation under actual conditions and suggests the need to realize the currently applied emission factor. | Kim, Wan-Soo; Baek, Seung-Min; Baek, Seung-Yun; Jeon, Hyeon-Ho; Siddique, Md. Abu Ayub; Kim, Taek-Jin; Lim, Ryu-Gap; Kim, Yong-Joo | Kyungpook Natl Univ, Dept Bioind Machinery Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Upland Field Machinery Res Ctr, Daegu 41566, South Korea; Chungnam Natl Univ, Dept Smart Agr Syst, Daejeon 34134, South Korea; Chungnam Natl Univ, Dept Biosyst Machinery Engn, Daejeon 34134, South Korea; TYM R&D Ctr, Dept Drive Syst Team, Iksan 54576, South Korea; Korea Agr Technol Promot Agcy, Dept Smart Agr, Iksan 54667, South Korea | Siddique, PhD, Md. Abu Ayub/AAB-6607-2021; Kim, Yong-Joo/AAK-1840-2021 | 57192918810; 57204040500; 57216612175; 57204036949; 57192431042; 57211191417; 57216499874; 57204759454 | babina@cnu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 2.45 | 2025-05-07 | 6 | 6 | VEHICLES; TESTS | agricultural worker; air pollutant; article; controlled study; diesel engine; human; paddy field; World Health Organization | English | 2024 | 2024-02-12 | 10.1038/s41598-024-53995-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Exogenous melatonin induces salt and drought stress tolerance in rice by promoting plant growth and defense system | Due to global climate change, crops are certainly confronted with a lot of abiotic and biotic stress factors during their growth that cause a serious threat to their development and overall productivity. Among different abiotic stresses, salt and drought are considered the most devastating stressors with serious impact on crop's yield stability. Here, the current study aimed to elucidate how melatonin works in regulating plant biomass, oxidative stress, antioxidant defense system, as well as the expression of genes related to salt and drought stress in rice plants. Eight groups of rice plants (3 replicates, 5 plants each) underwent varied treatments: control, melatonin, salt, drought, salt + drought, salt + melatonin, drought + melatonin, and salt + drought + melatonin. Melatonin (100 mu M) was alternately applied a week before stress exposure; salt stress received 100 mM NaCl every 3 days for 3 weeks, and drought stress involved 10% PEG. Young leaves were randomly sampled from each group. The results showed that melatonin treatment markedly reduces salt and drought stress damage by promoting root, shoot length, fresh and dry weight, increasing chlorophyll contents, and inhibiting excessive production of oxidative stress markers. Salt and drought stress significantly decreased the water balance, and damaged cell membrane by reducing relative water contents and increasing electrolyte leakage. However, melatonin treated rice plants showed high relative water contents and low electrolyte leakage. Under salt and drought stress conditions, exogenous application of melatonin boosted the expression level of salt and drought stress responsive genes like OsSOS, OsNHX, OsHSF and OsDREB in rice plants. Taken together, our results reveal that melatonin treatment significantly increases salt and drought tolerance of rice plants, by increasing plant biomass, suppressing ROS accumulation, elevating antioxidants defense efficiency, and up-regulating the expression of salt and drought stress responsive genes. | Khan, Zakirullah; Jan, Rahmatullah; Asif, Saleem; Farooq, Muhammad; Jang, Yoon-Hee; Kim, Eun-Gyeong; Kim, Nari; Kim, Kyung-Min | Kyungpook Natl Univ, Grad Sch, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Coastal Agr Res Inst, Daegu 41566, South Korea | Jan, Rahmatullah/AIC-3439-2022; Kim, Kyung-Min Kim/C-7007-2014; Farooq, Muhammad/JFS-9859-2023 | 58810294300; 57201981969; 57396413700; 57215544380; 57219901992; 57221496070; 57395985700; 34868260300 | rehmatbot@yahoo.com;kkm@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 19.62 | 2025-05-07 | 48 | 52 | ORYZA-SATIVA L.; TRANSCRIPTION FACTOR; OXIDATIVE STRESS; ANTIOXIDANT ENZYMES; ABIOTIC STRESS; CLIMATE-CHANGE; HEAT-STRESS; SALINITY; WHEAT; GENE | Antioxidants; Drought Resistance; Droughts; Electrolytes; Melatonin; Oryza; Plant Proteins; Stress, Physiological; Water; antioxidant; electrolyte; melatonin; plant protein; water; drought; drought resistance; genetics; metabolism; Oryza; physiological stress | English | 2024 | 2024-01-12 | 10.1038/s41598-024-51369-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | External archive guided radial-grid multi objective differential evolution | Differential evolution (DE) is a robust evolutionary algorithm for solving single-objective and multi-objective optimization problems (MOPs). While numerous multi-objective DE (MODE) variants exist, prior research has primarily focused on parameter control and mutation operators, often neglecting the issue of inadequate population distribution across the objective space. This paper proposes an external archive-guided radial-grid-driven differential evolution for multi-objective optimization (Ar-RGDEMO) to address these challenges. The proposed Ar-RGDEMO incorporates three key components: a novel mutation operator that integrates a radial-grid-driven strategy with a performance metric derived from Pareto front estimation, a truncation procedure that employs Pareto dominance in conjunction with a ranking strategy based on shifted similarity distances between candidate solutions, and an external archive that preserves elite individuals using a clustering approach. Experimental results on four sets of benchmark problems demonstrate that the proposed Ar-RGDEMO exhibits competitive or superior performance compared to seven state-of-the-art algorithms in the literature. | Palakonda, Vikas; Ghorbanpour, Samira; Kang, Jae-Mo; Jung, Heechul | Kyungpook Natl Univ, Dept Artificial Intelligence, Daegu, South Korea; Laurentian Univ, Bharti Sch Engn & Comp Sci, Sudbury, ON, Canada | 57193028485; 57207109590; 56024930400; 55652175200 | heechul@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0.82 | 2025-05-07 | 2 | 2 | ALGORITHM; OPTIMIZATION | algorithm; article; benchmarking; controlled study; evolution; evolutionary algorithm; human; multiobjective optimization; population distribution | English | 2024 | 2024-11-22 | 10.1038/s41598-024-76877-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Feasibility of images acquired using smartphone camera for marginal and internal fit of fixed dental prosthesis: comparison and correlation study | This study aimed to measure marginal and internal fit using images captured with both an optical microscope and a smartphone camera, comparing the fit measurement performance of these devices and analyzing their correlation. Working casts (with 10 posterior and 10 anterior teeth) created to fabricate fixed dental prostheses were used. These working casts were scanned using a desktop scanner (E1) to design an interim crown, and the designed interim crown was fabricated using a three-dimensional (3D) printer. Utilizing the silicone replica technique, the fabricated interim crown replicated the fit, which was then captured using both an optical microscope and a smartphone camera. The captured images were used to measure the marginal and internal fit according to the imaging device. Intraclass correlation coefficients (ICC) were used for reliability analysis according to the imaging device. Furthermore, the Wilcoxon signed-rank test was adopted for the comparative evaluation of the marginal and internal fit between the imaging devices (alpha = 0.05). The measurement results of the marginal and internal fit according to the optical microscope and smartphone camera did exhibit a significant difference (P < 0.05). The ICC between the two devices showed an "excellent" agreement of over 0.9 at all measurement points (P < 0.001). A smartphone camera could be used to obtain images for evaluating the marginal and internal fit. | Son, Young-Tak; Son, Keunbada; Eo, Gyeong-o; Lee, Kyu-Bok | Kyungpook Natl Univ, Grad Sch, Dept Dent Sci, Daegu, South Korea; Kyungpook Natl Univ, Adv Dent Device Dev Inst, 2177 Dalgubuldaero, Daegu 41940, South Korea; Yonam Inst Technol, Dept Smart Software, Jinju, Gyeongsangnam D, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, Daegu, South Korea | Son, Keunbada/AAG-8089-2019; SON, Keunbada/AAG-8089-2019 | 57219111205; 57202916520; 58918267500; 15925571200 | kblee@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0 | 2025-05-07 | 0 | 0 | Smartphone camera; Optical microscope; Intraclass correlation coefficients; Marginal and internal fit | INTRACLASS CORRELATION-COEFFICIENTS; RELIABILITY; MICROSCOPE; LENS | Intraclass correlation coefficients; Marginal and internal fit; Optical microscope; Smartphone camera | Correlation of Data; Dental Prosthesis; Feasibility Studies; Reproducibility of Results; Smartphone; data correlation; feasibility study; reproducibility | English | 2024 | 2024-03-04 | 10.1038/s41598-024-55711-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Genetic characterization and phylogenetic analysis of the Nigella sativa (black seed) plastome | In this study, the complete plastome sequence of Nigella sativa (black seed), was analyzed for the first time. The plastome spans approximately 154,120 bp, comprising four sections: the Large Single-Copy (LSC) (85,538 bp), the Small Single-Copy (SSC) (17,984 bp), and two Inverted Repeat (IR) regions (25,299 bp). A comparative study of N. sativa's plastome with ten other species from various genera in the Ranunculaceae family reveals substantial structural variations. The contraction of the inverted repeat region in N. sativa influences the boundaries of single-copy regions, resulting in a shorter plastome size than other species. When comparing the plastome of N. sativa with those of its related species, significant divergence is observed, particularly except for N. damascena. Among these, the plastome of A. glaucifolium displays the highest average pairwise sequence divergence (0.2851) with N. sativa, followed by A. raddeana (0.2290) and A. coerulea (0.1222). Furthermore, the study identified 12 distinct hotspot regions characterized by elevated Pi values (> 0.1). These regions include trnH-GUG-psbA, matK-trnQ-UUG, psbK-trnR-UCU, atpF-atpI, rpoB-psbD, ycf3-ndhJ, ndhC-cemA, petA-psaJ, trnN-GUU-ndhF, trnV-GAC-rps12, ycf2-trnI-CAU, and ndhA-ycf1. Approximately, 24 tandem and 48 palindromic and forward repeats were detected in N. sativa plastome. The analysis revealed 32 microsatellites with the majority being mononucleotide repeats. In the N. sativa plastome, phenylalanine had the highest number of codons (1982 codons), while alanine was the least common amino acid with 260 codons. A phylogenetic tree, constructed using protein-coding genes, revealed a distinct monophyletic clade comprising N. sativa and N. damascene, closely aligned with the Cimicifugeae tribe and exhibiting robust support. This plastome provides valuable genetic information for precise species identification, phylogenetic resolution, and evolutionary studies of N. sativa. | Asaf, Sajjad; Khan, Ibrahim; Jan, Rahmatullah; Asif, Saleem; Bilal, Saqib; Kim, Kyung-Min; AL-Harrasi, Ahmed | Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa 616, Oman; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea | Asaf, Sajjad/ABA-3647-2021; Kim, Kyung-Min Kim/C-7007-2014; Jan, Rahmatullah/AIC-3439-2022; Ul-Hamid, Anwar/B-7297-2015 | 57200621537; 56595059900; 57191379139; 57201981969; 57396413700; 57031617400; 34868260300; 6506093146 | sajadasif2000@gmail.com;kkm@knu.ac.kr;aharrasi@unizwa.edu.om; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 1.23 | 2025-05-07 | 0 | 3 | N. sativa; Plastome; Divergence; Hotspot regions; Phylogenetic study | COMPLETE CHLOROPLAST GENOME; INVERTED REPEAT COPIES; STRUCTURAL ORGANIZATION; INVERSION VARIATION; COMPLETE SEQUENCE; DNA INVERSION; RANUNCULACEAE; RECOMBINATION; SOFTWARE; L. | Divergence; Hotspot regions; N. sativa; Phylogenetic study; Plastome | Genome, Plastid; Nigella sativa; Phylogeny; black cumin; chemistry; genetics; phylogeny; plastid genome | English | 2024 | 2024-06-24 | 10.1038/s41598-024-65073-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Global intracranial arterial tortuosity is associated with intracranial atherosclerotic burden | The effect of arterial tortuosity on intracranial atherosclerosis (ICAS) is not well understood. This study aimed to evaluate the effect of global intracranial arterial tortuosity on intracranial atherosclerotic burden in patients with ischemic stroke. We included patients with acute ischemic stroke who underwent magnetic resonance angiography (MRA) and classified them into three groups according to the ICAS burden. Global tortuosity index (GTI) was defined as the standardized mean curvature of the entire intracranial arteries, measured by in-house vessel analysis software. Of the 516 patients included, 274 patients had no ICAS, 140 patients had a low ICAS burden, and 102 patients had a high ICAS burden. GTI increased with higher ICAS burden. After adjustment for age, sex, vascular risk factors, and standardized mean arterial area, GTI was independently associated with ICAS burden (adjusted odds ratio [adjusted OR] 1.33; 95% confidence interval [CI] 1.09-1.62). The degree of association increased when the arterial tortuosity was analyzed limited to the basal arteries (adjusted OR 1.48; 95% CI 1.22-1.81). We demonstrated that GTI is associated with ICAS burden in patients with ischemic stroke, suggesting a role for global arterial tortuosity in ICAS. | Eun, Mi-Yeon; Song, Ha-Na; Choi, Jong-Un; Cho, Hwan-Ho; Kim, Hyung Jun; Chung, Jong-Won; Song, Tae-Jin; Jung, Jin-Man; Bang, Oh-Young; Kim, Gyeong-Moon; Park, Hyunjin; Liebeskind, David S.; Seo, Woo-Keun | Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu, South Korea; Korea Univ, Grad Sch, Dept Neurol, Seoul, South Korea; Sungkyunkwan Univ, Dept Neurol, Sch Med, 81,Irwon Ro, Seoul 06351, South Korea; Sungkyunkwan Univ, Stroke Ctr, Samsung Med Ctr, Sch Med, 81,Irwon Ro, Seoul 06351, South Korea; Sungkyunkwan Univ, Dept Digital Hlth, SAIHST, Sch Med, Seoul, South Korea; Incheon Natl Univ, Dept Elect Engn, Incheon, South Korea; Ewha Womans Univ, Coll Med, Seoul Hosp, Dept Neurol, Seoul, South Korea; Korea Univ, Coll Med, Dept Neurol, Ansan Hosp, Ansan, South Korea; Sungkyunkwan Univ, Dept Elect & Comp Engn, Suwon, South Korea; Inst Basic Sci IBS, Ctr Neurosci Imaging Res, Suwon, South Korea; Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA USA | Liebeskind, David/B-1991-2008; Bang, Ole/E-6158-2010; Jung, Jin-Man/LJL-8037-2024; Eun, Mi-Yeon/AAV-2877-2021; Park, Hyunjin/A-1164-2007 | 36463396500; 59133897800; 59133109000; 59132708000; 55635231700; 55553751200; 55507164200; 15755814800; 7006620221; 59132708100; 56512679000; 7004045734; 22981667600 | mcastenosis@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0 | 2025-05-07 | 0 | 0 | Tortuosity; Intracranial atherosclerosis; Stroke | VASCULAR TORTUOSITY; CAROTID-ARTERY; HEMODYNAMICS; BIFURCATION; KINKING; RISK | Intracranial atherosclerosis; Stroke; Tortuosity | Aged; Arterial Tortuosity Syndrome; Arteries; Cerebral Arteries; Female; Humans; Intracranial Arteriosclerosis; Ischemic Stroke; Joint Instability; Magnetic Resonance Angiography; Male; Middle Aged; Risk Factors; Skin Diseases, Genetic; Vascular Malformations; aged; artery; brain artery; cerebral atherosclerosis; complication; congenital blood vessel malformation; diagnostic imaging; female; human; ischemic stroke; joint instability; magnetic resonance angiography; male; middle aged; pathology; risk factor; skin disease | English | 2024 | 2024-05-17 | 10.1038/s41598-024-61527-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Gut microbiome perturbation and its correlation with tylosin pharmacokinetics in healthy and infected pigs | Tylosin, an antibiotic with a long history in treating respiratory bacterial infections, has unknown effects on the gut microbiota of healthy and infected pigs. The study aimed to investigate the effect of a therapeutic dose of tylosin on swine gut microbiota and explored the relationship between this effect and tylosin pharmacokinetics (PK). We also assessed whether changes in gut microbiota after tylosin administration differ between healthy animals (n = 7) and animals intranasally co-infected (n = 7) with Actinobacillus pleuropneumoniae and Pasteurella multocida. Both groups were intramuscularly administered with tylosin (20 mg/kg). The 16S rRNA gene analyses revealed a significantly lower species richness and diversity, after tylosin treatment, in the infected than the healthy pigs, with infected pigs having lower levels of Bacteroidetes and Firmicutes and higher levels of Proteobacteria. Greater tylosin exposure (greater area under curve (AUC) and maximum plasma concentration (C-max), and slower elimination (longer terminal half-life, T-1/2) were observed in healthy than infected pigs. Relative abundance of Lactobacillus, Oscillibacter, Prevotella, and Sporobacter was positively and significantly correlated with AUC and C-max, whereas the abundance of Acinetobacter, Alishewanella, and Pseudomonas was positively and significantly correlated with T-1/2 and mean residence time (MRT) of tylosin. Our findings, for the first time, demonstrated significant changes in swine gut microbiota after a single therapeutic dose of tylosin was administered, whereas the effect of these changes on tylosin PK was not evident. | Lee, Eon-Bee; Lee, Ga-Yeong; Hossain, Md Akil; Awji, Elias Gebru; Park, Seung-Chun | Kyungpook Natl Univ, Inst Vet Biomed Sci, Coll Vet Med, Lab Vet Pharmacokinet & Pharmacodynam, Daegu 41566, South Korea; Univ Illinois, Inst TB Res, Coll Pharm, 833 S Wood St, Chicago, IL 60612 USA; NCI, Rockville, MD 20852 USA; Kyungpook Natl Univ, Cardiovasc Res Inst, Daegu 41566, South Korea | Lee, Jung Bok/HHZ-3200-2022; Park, Seung-Chun/AAV-3388-2021; Hossain, Akil/AAY-7229-2020 | 57216526135; 58413330500; 55754133800; 55429715100; 7501832396 | parksch@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0 | 2025-05-07 | 0 | 0 | Tylosin; Gut microbiota; Pharmacokinetics; Pharmacomicrobiomics; Actinobacillus pleuropneumoniae; Pasteurella multocida | INTESTINAL MICROBIOTA; SWINE; SUSCEPTIBILITY; MICROORGANISMS; IDENTIFICATION; METABOLISM; PATHOGENS; CYTOKINES; BACTERIA | Actinobacillus pleuropneumoniae; Gut microbiota; Pasteurella multocida; Pharmacokinetics; Pharmacomicrobiomics; Tylosin | Actinobacillus pleuropneumoniae; Animals; Anti-Bacterial Agents; Gastrointestinal Microbiome; Pasteurella multocida; RNA, Ribosomal, 16S; Swine; Swine Diseases; Tylosin; antiinfective agent; RNA 16S; tylosin; Actinobacillus pleuropneumoniae; animal; drug effect; drug therapy; genetics; intestine flora; microbiology; Pasteurella multocida; pig; swine disease | English | 2024 | 2024-08-12 | 10.1038/s41598-024-69566-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | HSPA9 reduction exacerbates symptoms and cell death in DSS-Induced inflammatory colitis | Inflammatory bowel disease (IBD) is a chronic inflammatory condition that is influenced by various factors, including environmental factors, immune responses, and genetic elements. Among the factors that influence IBD progression, macrophages play a significant role in generating inflammatory mediators, and an increase in the number of activated macrophages contributes to cellular damage, thereby exacerbating the overall inflammatory conditions. HSPA9, a member of the heat shock protein 70 family, plays a crucial role in regulating mitochondrial processes and responding to oxidative stress. HSPA9 deficiency disrupts mitochondrial dynamics, increasing mitochondrial fission and the production of reactive oxygen species. Based on the known functions of HSPA9, we considered the possibility that HSPA9 reduction may contribute to the exacerbation of colitis and investigated its relevance. In a dextran sodium sulfate-induced colitis mouse model, the downregulated HSPA9 exacerbates colitis symptoms, including increased immune cell infiltration, elevated proinflammatory cytokines, decreased tight junctions, and altered macrophage polarization. Moreover, along with the increased mitochondrial fission, we found that the reduction in HSPA9 significantly affected the superoxide dismutase 1 levels and contributed to cellular death. These findings enhance our understanding of the intricate mechanisms underlying colitis and contribute to the development of novel therapeutic approaches for this challenging condition. | Jang, Soyoung; Jang, Soyeon; Ko, Jiwon; Bae, Ji-Eun; Hyung, Hyejin; Park, Ji Yeong; Lim, Su-Geun; Park, Sijun; Park, Song; Yi, Junkoo; Kim, Seonggon; Kim, Myoung Ok; Cho, Dong-Hyung; Ryoo, Zae Young | Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat Biores Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, KNU Inst Basic Sci, Coll Nat Sci, KNU LAMP Res Ctr, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Life Sci & Biotechnol, Daegu 41566, South Korea; Gyeongsang Natl Univ, Dept Anim Sci, Jinju 52828, South Korea; Gyeongsang Natl Univ, Inst Agr & Life Sci IALS, Jinju 52828, South Korea; Hankyong Natl Univ, Sch Anim Life Convergence Sci, Anseong 17579, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Preclin Res Ctr, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Innovat Anim Sci, Dept Anim Sci & Biotechnol, Sangju Si 37224, Gyeongsang Buk, South Korea; Kyungpook Natl Univ, Organelle Inst, Daegu 41566, South Korea; ORGASIS Corp, Suwon 16229, Gyeonggido, South Korea | Choi, Hye Rin/JDV-9065-2023; RYOO, ZAEYOUNG/AAQ-1573-2020 | 57139360300; 57226661947; 57226659428; 57190605352; 57247294000; 57247511800; 56044587400; 54682212300; 57139047900; 56182537200; 55718780800; 8934745900; 35093684400; 16937104900 | jangsy@knu.ac.kr;dhcho@knu.ac.kr;jaewoong64@hanmail.net; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0.82 | 2025-05-07 | 1 | 2 | MITOCHONDRIAL; MORTALIN; MACROPHAGES | Animals; Cell Death; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Inflammatory Bowel Diseases; Macrophages; Mice; Mice, Inbred C57BL; Oxidative Stress; cytokine; dextran sulfate; animal; C57BL mouse; cell death; colitis; colon; disease model; inflammatory bowel disease; macrophage; metabolism; mouse; oxidative stress | English | 2024 | 2024-03-11 | 10.1038/s41598-024-56216-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Identification of novel therapeutic targets for head and neck squamous cell carcinoma through bioinformatics analysis | Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous cancer with limited therapeutic options. Using publicly available datasets, we identified the WD repeat domain 54 (WDR54) gene as a potential therapeutic target in HNSCC. Gene expression profiling interactive analysis version 2 (GEPIA2) was used to identify genes differentially overexpressed in HNSCC. Our results showed that WDR54, a member of the WD40 repeat domain family, was overexpressed in HNSCC tumor samples. Analysis of three gene expression omnibus datasets showed that WDR54 was overexpressed in tumor samples. Using the UALCAN database, we showed that WDR54 expression in patients with HNSCC at different tumor stages gradually increased with disease progression. We confirmed the association between WDR54 and metastasis using TNMplot.com. WDR54 was overexpressed in metastatic samples compared to that in normal and tumor samples. Kaplan-Meier analysis showed that patients with high WDR54 levels had a poorer prognosis. Additionally, WDR54 expression was correlated with the epidermal growth factor receptor, which is frequently overexpressed in HNSCC. Our findings suggest that WDR54 is a promising biomarker and therapeutic target in HNSCC. | Jeong, Eun-jeong; Kim, Eunjeong; Kim, Yeon Soo | Konyang Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Daejeon, South Korea; Kyungpook Natl Univ, FOUR KNU Creat Biores Grp BK21, KNU G LAMP Res Ctr, Dept Biol,Coll Nat Sci,Inst Basic Sci,KNU, Daegu 41566, South Korea; Korea Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul 35365, South Korea | 57205177104; 56892981600; 57207443122 | ionskim@korea.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0.41 | 2025-05-07 | 2 | 2 | Head and neck squamous cell carcinoma; WD repeat domain 54; Gene expression profiling interactive analysis web server; Gene expression omnibus | WD40 REPEAT PROTEIN; GENE-EXPRESSION; CANCER; PHOSPHORYLATION; BIOMARKERS; TUMOR; TOOL | Gene expression omnibus; Gene expression profiling interactive analysis web server; Head and neck squamous cell carcinoma; WD repeat domain 54 | Biomarkers, Tumor; Computational Biology; ErbB Receptors; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Kaplan-Meier Estimate; Male; Molecular Targeted Therapy; Prognosis; Squamous Cell Carcinoma of Head and Neck; epidermal growth factor receptor; tumor marker; bioinformatics; female; gene expression profiling; gene expression regulation; genetics; head and neck squamous cell carcinoma; head and neck tumor; human; Kaplan Meier method; male; metabolism; molecularly targeted therapy; pathology; procedures; prognosis | English | 2024 | 2024-12-30 | 10.1038/s41598-024-83680-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Importance of dialysis specialists in early mortality in elderly hemodialysis patients: a multicenter retrospective cohort study | The early mortality rate in elderly patients undergoing hemodialysis is more than twice that in young patients, requiring more specialized healthcare. We investigated whether the number of professional dialysis specialists affected early mortality in elderly patients undergoing hemodialysis. This multicenter retrospective cohort study analyzed data from 1860 patients aged >= 70 years who started hemodialysis between January 2010 and December 2017. Study regions included Seoul, Gyeonggi-do, Gangwon-do, Daejeon/Chungcheong-do, Daegu/Gyeongsangbuk-do, and Busan/Ulsan/Gyeongsangnam-do. The number of patients undergoing hemodialysis per dialysis specialist was calculated using registered data from each hemodialysis center. Early mortality was defined as death within 6 months of hemodialysis initiation. Gangwon-do (28.3%) and Seoul (14.5%) showed the highest and lowest early mortality rate, respectively. Similarly, Gangwon-do (64.6) and Seoul (43.9) had the highest and lowest number of patients per dialysis specialist, respectively. Relatively consistent results were observed for the regional rankings of early mortality rate and number of patients per dialysis specialist. Multivariate Cox regression analysis-adjusted for previously known significant risk factors-revealed that the number of patients per dialysis specialist was an independent risk factor for early mortality (hazard ratio: 1.031, p < 0.001). This study underscores the growing need for dialysis specialists for elderly hemodialysis patients in Korea. | Park, Yohan; Lee, Ji Won; Yoon, Se-Hee; Yun, Sung-Ro; Kim, Hyunsuk; Bae, Eunjin; Hyun, Young Youl; Chung, Sungjin; Kwon, Soon Hyo; Cho, Jang-Hee; Yoo, Kyung Don; Park, Woo Yeong; Sun, In O.; Yu, Byung Chul; Ko, Gang-Jee; Yang, Jae Won; Song, Sang Heon; Shin, Sung Joon; Hong, Yu Ah; Hwang, Won Min | Konyang Univ Hosp, Dept Internal Med, Div Nephrol, Daejeon, South Korea; Konyang Univ, Myunggok Med Res Inst, Daejeon, South Korea; Hallym Univ, Chuncheon Sacred Heart Hosp, Med Ctr, Dept Internal Med,Div Nephrol, Chunchon, South Korea; Gyeongsang Natl Univ Hosp, Dept Internal Med, Div Nephrol, Jinju, South Korea; Kangbuk Samsung Hosp, Dept Internal Med, Div Nephrol, Seoul, South Korea; Yeouido St Marys Hosp, Dept Internal Med, Div Nephrol, Seoul, South Korea; Soonchunhyang Univ, Seoul Hosp, Dept Internal Med, Div Nephrol, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Div Nephrol, Daegu, South Korea; Ulsan Univ Hosp, Dept Internal Med, Div Nephrol, Ulsan, South Korea; Keimyung Univ, Dongsan Hosp, Dept Internal Med, Div Nephrol, Daegu, South Korea; Presbyterian Med Ctr, Dept Internal Med, Div Nephrol, Jeonju, South Korea; Soonchunhyang Univ, Bucheon Hosp, Dept Internal Med, Div Nephrol, Bucheon, South Korea; Korea Univ, Guro Hosp, Dept Internal Med, Div Nephrol, Seoul, South Korea; Yonsei Univ, Wonju Severance Christian Hosp, Dept Internal Med, Div Nephrol, Wonju, South Korea; Pusan Natl Univ Hosp, Dept Internal Med, Div Nephrol, Busan, South Korea; Dongguk Univ, Ilsan Hosp, Dept Internal Med, Div Nephrol, Goyang, South Korea; Daejeon St Marys Hosp, Dept Internal Med, Div Nephrol, Daejeon, South Korea | ; 이, 지원/HTO-1175-2023; Hong, Yu/AAB-7055-2020; Chung, Sungjin/AAJ-8836-2020; Cho, Jang-hee/ABD-3534-2020; Yoo, Kyung/AAK-8096-2020; Park, Woo Yeong/AGK-9140-2022 | 57216616078; 58827113400; 55285801300; 36097271300; 57194217507; 55880508000; 57037163300; 23388171000; 57204097241; 7403536291; 56603636300; 36344980100; 36994821600; 57203908496; 8310760600; 59285795300; 36162581500; 55662651000; 55125210000; 55568773500 | hwangwm@kyuh.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0.41 | 2025-05-07 | 0 | 2 | 6-MONTH MORTALITY; PRACTICE PATTERNS; DECISION-MAKING; INITIATION; ASSOCIATION; PREDICTORS; OUTCOMES; DISEASE; SCORE | Aged; Cognition; Health Facilities; Humans; Multivariate Analysis; Renal Dialysis; Retrospective Studies; aged; clinical trial; cognition; health care facility; hemodialysis; human; multicenter study; multivariate analysis; retrospective study | English | 2024 | 2024-01-22 | 10.1038/s41598-024-52170-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Increased cardiovascular risk in Korean patients with systemic lupus erythematosus: a population-based cohort study | To determine the increased risk of major adverse cardiovascular events (MACE) in patients with systemic lupus erythematosus (SLE) compared to the general population in Korea. Using data from the National Health Insurance Service database spanning 2008 to 2018, incident SLE patients aged 18 years and above were selected along with a 1:4 age- and sex-matched control group. The crude incidence rate (IR) of MACE was calculated as the number of events per 1000 person-years and the IR ratio (IRR) for MACE was adjusted using generalized estimating equations. Subgroup analysis was conducted to evaluate the risk differences of overall MACE and its composites based on age and sex stratification. The study included 8568 SLE patients and 34,272 controls. The cumulative IR of MACE per 1000 person-years in SLE patients and controls were 4.08 and 1.30, respectively. After adjusting for confounders, SLE patients had a higher risk of MACE compared to the general population (adjusted IRR of 2.40 [95% confidence interval [CI] 1.88-3.05]), with no gender differences observed. The increased risk of MACE in SLE patients was highest in the 18-39 age group (IRR 11.70, 95% CI 5.95-23.01) and gradually decreased with age. The increased risk of ischemic stroke (IRR 2.41, 95% CI 1.84-3.15) and myocardial infarction (IRR 2.19, 95% CI 1.30-3.68) in SLE patients was comparable. The risk of MACE in SLE patients is 2.40 times higher than that of the general population, with a higher relative risk observed in younger individuals. | Han, Jung-Yong; Cho, Soo-Kyung; Kim, Hyoungyoung; Jeon, Yena; Kang, Gaeun; Jung, Sun-Young; Jang, Eun Jin; Sung, Yoon-Kyoung | Hanyang Univ, Hosp Rheumat Dis, Dept Rheumatol, Seoul, South Korea; Hanyang Univ, Inst Rheumatol Res, Seoul, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Chung Ang Univ, Coll Pharm, Seoul, South Korea; Andong Natl Univ, Dept Informat Stat, Andong, South Korea | 57220065429; 35185890800; 57202108695; 57209909350; 58808701500; 57207445502; 37861741600; 15754508900 | sungyk@hanyang.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 1.23 | 2025-05-07 | 4 | 4 | MYOCARDIAL-INFARCTION; REVISED CRITERIA; ATHEROSCLEROSIS; EVENTS; CLASSIFICATION; PREDICTORS; MORTALITY; DISEASE; STROKE; LUMINA | Adolescent; Adult; Cardiovascular Diseases; Cohort Studies; Heart Disease Risk Factors; Humans; Incidence; Lupus Erythematosus, Systemic; Republic of Korea; Risk Factors; Young Adult; adolescent; adult; cardiovascular disease; cohort analysis; complication; heart disease risk factor; human; incidence; risk factor; South Korea; systemic lupus erythematosus; young adult | English | 2024 | 2024-01-11 | 10.1038/s41598-024-51546-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | Article | Intravascular ultrasound-guided versus angiography-guided percutaneous coronary intervention for acute myocardial infarction with cardiogenic shock | The benefits of intravascular ultrasonography (IVUS)-guided percutaneous coronary intervention (PCI) in the clinical context of cardiogenic shock (CS) complicating acute myocardial infarction are lacking. We aimed to investigate the impact of IVUS-guided PCI in patients with AMI and CS. From the pooled data based on a series of Korean AMI registries during 2011–2020, we identified 1418 consecutive patients who underwent PCI with second generation drug-eluting stent (DES) for AMI and CS. The primary endpoint was the 1-year rate of target lesion failure (TLF), defined as the composite of cardiac death, target vessel myocardial infarction, and ischemic-driven target lesion revascularization. In total, 294 (20.7%) and 1124 (79.3%) underwent IVUS-guided and angiography-guided PCI with second generation DES implantation, respectively. The 1-year TLF was not significantly different between groups after IPTW analysis (hazard ratio 0.93, 95% confidence interval 0.65–1.34, p = 0.70). Additionally, the adjusted landmark analysis for TLF at 30 days and between 30 days and 1 year after PCI demonstrated no significant difference between the groups. In conclusion, in patients with AMI and CS who underwent PCI with second-generation DES, IVUS-guided PCI did not improve the 1-year TLF compared with angiography-guided PCI. Registration: URL: http://cris.nih.go.kr. KCT0000863 and KCT0008355. © The Author(s) 2024. | Lee, Oh-Hyun; Heo, Seok-Jae; Johnson, Thomas W.; Kim, Yongcheol; Cho, Deok-Kyu; Kim, Jung-Sun; Kim, Byeong-Keuk; Choi, Donghoon; Hong, Myeong-Ki; Jang, Yangsoo; Jeong, Myung Ho; Ahn, Tae Hoon; Seung, Ki Bae; Rha, Seung-Woon; Kim, Hyo-Soo; Yoon, Chang-Hwan; Gwon, Hyeon-Cheol; Kim, Chong-Jin; Yoon, Junghan; Seong, In-Whan; Hwang, Kyung-Kuk; Chae, Jei Keon; Oh, Seok Kyu; Lee, Jung-Hee; Chae, Shung Chull; Hur, Seung-Ho; Cha, Kwang Soo; Hwang, Jin-Yong; Kim, Doo-Il; Joo, Seung-Jae; Chang, KiYuk; Kim, Hee-Yeol; Yoo, Ki-Dong; Yoo, Sang-Yong; Kim, Weon; Rha, Seung-Woon; Nah, Deuk-Young; Yoon, Chang-Hwan; Kim, Hyo-Soo; Gwon, Hyeon-Cheol; Cho, Jang Hyun; Park, Jong-Seon; Lee, Kyu-Sun; Rhew, Jay-Young; Yang, Yong-Mo; Kim, Sang-Hyun; Park, Yong Hwan; Kwon, Sung Uk; Kim, Dong-Bin; Cho, Byung Ryul; Lee, Seung-Uk; Bae, Jang Ho; Lim, Sang Yup; Kim, Kee Sik; Kim, Moo Hyun; Park, Sang-Ho; Tak, Seung Je; Woo, Sung-Il; Kim, Byung Ok | Yonsei University College of Medicine and Cardiovascular Center, Yongin Severance Hospital, 363 Dongbaekjukjeon-Daero, Giheung-Gu, Yongin, 16995, South Korea; Division of Biostatistics, Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, South Korea; Bristol Heart Institute, Bristol, United Kingdom; Yonsei University College of Medicine and Cardiovascular Center, Yongin Severance Hospital, 363 Dongbaekjukjeon-Daero, Giheung-Gu, Yongin, 16995, South Korea; Yonsei University College of Medicine and Cardiovascular Center, Yongin Severance Hospital, 363 Dongbaekjukjeon-Daero, Giheung-Gu, Yongin, 16995, South Korea; Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, South Korea; Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, South Korea; Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, South Korea; Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, South Korea; Department of Cardiology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South Korea; Chonnam National University Hospital and Medical School, Gwangju, South Korea, Department of Cardiology, Principal investigator of the Korea Acute Myocardial Infarction Registry, Chonnam National University Hospital, 42 Jebong-Ro, Dong-Gu, Gwangju, 61469, South Korea, Chonnam National University Hospital, Gwangju, South Korea; Gachon University Gil Medical Center, Incheon, South Korea; Seoul St. Mary’s Hospital, Seoul, South Korea; Korea University Guro Hospital, Seoul, South Korea; Seoul National University Hospital, Seoul, South Korea; Seoul National University Bundang Hospital, Seongnam-si, South Korea; Samsung Medical Center, Seoul, South Korea; Gangdong Kyunghee University Hospital, Seoul, South Korea; Wonju Severance Christian Hospital, Wonju, South Korea; Chungnam National University Hospital, Daejeon, South Korea; Chungbuk National University Hospital, Cheongju-si, South Korea; Chonbuk National University Hospital, Jeonju-si, South Korea; Wonkwang University Hospital, Iksan-si, South Korea; Yeungnam University Medical Center, Daegu, South Korea; Kyungpook National University Hospital, Daegu, South Korea; Keimyung University Dongsan Medical Center, Daegu, South Korea; Pusan Natinoal University Hospital, Busan, South Korea, Pusan National University Hospital, Busan, South Korea; Gyeongsang National University Hospital, Jinju-si, South Korea; Inje University Haeundae Paik Hospital, Busan, South Korea; Jeju National University Hospital, Jeju-si, South Korea; Seoul St. Mary’s Hospital, Seoul, South Korea; Bucheon St. Mary’s Hospital, Bucheon-si, South Korea; St. Vincent Hospital, Darlinghurst, Australia; Gangneung Asan Hospital, Gangneung-si, South Korea; Kyunghee University Hospital, Seoul, South Korea; Korea University Guro Hospital, Seoul, South Korea; Dongguk University Gyeongju Hospital, Gyeongju-si, South Korea; Seoul National University Bundang Hospital, Seongnam-si, South Korea; Seoul National University Hospital, Seoul, South Korea; Samsung Medical Center, Seoul, South Korea; Suncheon St. Garolo Hospital, Suncheon-si, South Korea; Yeungnam University Hospital, Daegu, South Korea; Daejeon Eulji University Hospital, Daejeon, South Korea; Prebyterian Medical Center, New York, United States; Cheongju St. Mary’s Hospital, Cheongju-si, South Korea; Seoul Boramae Hospital, Seoul, South Korea; Samsung Changwon Hospital, Changwon-si, South Korea; Inje University Ilsan Paik Hospital, Goyang-si, South Korea; St. Paul’s Hospital, Vancouver, Canada; Kangwon National University Hospital, Chuncheon-si, South Korea; Kwangju Christian Hospital, Gwangju, South Korea; Konyang University Hospital, Daejeon, South Korea; Korea University Ansan Hospital, Ansan-si, South Korea; Daegu Catholic University Medical Center, Daegu, South Korea; Dong-A University Hospital, Busan, South Korea; Soonchunhyang University Cheonan Hospital, Cheonan-si, South Korea; Ajou University Hospital, Suwon-si, South Korea; Inha University Hospital, Incheon, South Korea; Inje University Sanggye Paik Hospital, Seoul, South Korea | 57192918238; 57203964055; 56418917800; 57192112249; 16068114900; 56025155100; 57221189789; 23110215500; 7402687966; 55429942500; 56485157500; 57222278496; 7003964208; 8569030400; 58843097000; 57666453500; 59464347800; 35229511500; 35760728900; 35254371300; 58842870300; 26029709000; 24734336000; 55969086000; 7101962036; 34570274500; 7102837700; 55892914700; 8635545900; 9236504200; 25521288100; 59733052700; 59844682200; 14631314800; 8570166100; 59968334100; 6507287036; 7202882965; 33567809200; 6603262426; 17136701300; 15763054600; 58085067700; 6603375779; 59732507800; 49663680000; 56799369500; 57212424081; 23090741800; 57189904025; 35798319900; 7201385490; 7404081251; 8400293100; 55686265600; 57189608309; 57195463876; 55628587057; 57199939573 | yongcheol@yuhs.ac;myungho@chollian.net; | Scientific Reports | SCI REP-UK | 2045-2322 | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0 | 2025-05-07 | 0 | Aged; Coronary Angiography; Drug-Eluting Stents; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Registries; Shock, Cardiogenic; Treatment Outcome; Ultrasonography, Interventional; aged; cardiogenic shock; comparative study; complication; coronary angiography; diagnostic imaging; female; heart infarction; human; interventional ultrasonography; male; middle aged; percutaneous coronary intervention; procedures; register; treatment outcome | English | Final | 2024 | 10.1038/s41598-024-59723-y | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Lactiplantibacillus plantarum K8 lysates regulate hypoxia-induced gene expression | Hypoxic responses have been implicated in critical pathologies, including inflammation, immunity, and tumorigenesis. Recently, efforts to identify effective natural remedies and health supplements are increasing. Previous studies have reported that the cell lysates and the cell wall-bound lipoteichoic acids of Lactiplantibacillus plantarum K8 (K8) exert anti-inflammatory and immunomodulative effects. However, the effect of K8 on cellular hypoxic responses remains unknown. In this study, we found that K8 lysates had a potent suppressive effect on gene expression under hypoxia. K8 lysates markedly downregulated hypoxia-induced HIF1 alpha accumulation in the human bone marrow and lung cancer cell lines, SH-SY5Y and H460. Consequently, the transcription of known HIF1 alpha target genes, such as p21, GLUT1, and ALDOC, was notably suppressed in the K8 lysate supplement and purified lipoteichoic acids of K8, upon hypoxic induction. Intriguingly, K8 lysates decreased the expression of PHD2 and VHL proteins, which are responsible for HIF1 alpha destabilization under normoxic conditions, suggesting that K8 may regulate HIF1 alpha stability in a non-canonical pathway. Overall, our results suggest that K8 lysates desensitize the cells to hypoxic stresses and suppress HIF1 alpha-mediated hypoxic gene activation. | Jeong, Jaehyeon; Kang, Byeong-Hee; Ju, Sangmin; Park, Na Yeon; Kim, Deukyeong; Dinh, Ngoc Thi Bao; Lee, Jeongho; Rhee, Chang Yun; Cho, Dong-Hyung; Kim, Hangeun; Chung, Dae Kyun; Bunch, Heeyoun | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea; Skin Biotechnol Ctr Co Ltd, Res & Dev Ctr, Yongin 17104, South Korea; Kyung Hee Univ, Grad Sch Biotechnol, Yongin 17104, South Korea | chung, dae/AAG-1058-2021; Bunch, Heeyoun/JAX-3215-2023; Choi, Hye Rin/JDV-9065-2023 | 57218602696; 58829058300; 58828036200; 57190609826; 57223415453; 58828550200; 58827517700; 58829058400; 35093684400; 27170094800; 7401719500; 56336812200 | heeyounbunch@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0.41 | 2025-05-07 | 1 | 1 | Hypoxic gene expression; Lactiplantibacillus plantarum K8; HIF1 alpha; Transcriptional regulation; Natural hypoxic response suppressor | INDUCIBLE FACTOR-I; LACTOBACILLUS-PLANTARUM; LIPOTEICHOIC ACID; HIF-1-ALPHA; CELLS; HIF-1; ACTIVATION; VHL; LIPOPOLYSACCHARIDE; FACTOR-1-ALPHA | HIF1α; Hypoxic gene expression; Lactiplantibacillus plantarum K8; Natural hypoxic response suppressor; Transcriptional regulation | Cell Hypoxia; Cell Line; Gene Expression; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Neuroblastoma; hypoxia inducible factor 1alpha; cell hypoxia; cell line; gene expression; genetics; human; hypoxia; metabolism; neuroblastoma | English | 2024 | 2024-03-15 | 10.1038/s41598-024-56958-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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