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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | The benefit of planned dialysis to early survival on hemodialysis versus peritoneal dialysis: a nationwide prospective multicenter study in Korea | Optimal preparation is recommended for patients with advanced chronic kidney disease to minimize complications during dialysis initiation. This study evaluated the effects of planned dialysis initiation on survival in patients undergoing incident hemodialysis and peritoneal dialysis. Patients newly diagnosed with end-stage kidney disease who started dialysis were enrolled in a multicenter prospective cohort study in Korea. Planned dialysis was defined as dialysis therapy initiated with permanent access and maintenance of the initial dialysis modality. A total of 2892 patients were followed up for a mean duration of 71.9 +/- 36.7 months and 1280 (44.3%) patients initiated planned dialysis. The planned dialysis group showed lower mortality than the unplanned dialysis group during the 1st and 2nd years after dialysis initiation (1st year: adjusted hazard ratio [aHR] 0.51; 95% confidence interval [CI] 0.37-0.72; P < 0.001; 2nd year: aHR 0.71; 95% CI 0.52-0.98, P = 0.037). However, 2 years after dialysis initiation, mortality did not differ between the groups. Planned dialysis showed a better early survival rate in hemodialysis patients, but not in peritoneal dialysis patients. Particularly, infection-related mortality was reduced only in patients undergoing hemodialysis with planned dialysis initiation. Planned dialysis has survival benefits over unplanned dialysis in the first 2 years after dialysis initiation, especially in patients undergoing hemodialysis. It improved infection-related mortality during the early dialysis period. | Lim, Jeong-Hoon; Kim, Ji Hye; Jeon, Yena; Kim, Yon Su; Kang, Shin-Wook; Yang, Chul Woo; Kim, Nam-Ho; Jung, Hee-Yeon; Choi, Ji-Young; Park, Sun-Hee; Kim, Chan-Duck; Kim, Yong-Lim; Cho, Jang-Hee | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, 130 Dongdeok ro, Daegu 41944, South Korea; Clin Res Ctr End Stage Renal Dis, Daegu, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea; Chonnam Natl Univ, Med Sch, Dept Internal Med, Gwangju, South Korea | Kim, Yong-Lim/AGK-3172-2022; Lim, Jeong-Hoon/ABE-6003-2020; Cho, Jang-hee/ABD-3534-2020; Jung, Hee-Yeon/AFB-8578-2022; Kim, Hyoungnae/JXN-1329-2024; Park, Sun-Hee/LMN-0033-2024 | 55360244300; 59643141000; 57209909350; 7410205767; 34768359700; 7407743404; 56605215700; 57196396467; 7501393222; 7501831741; 8558530700; 55633533600; 7403536291 | ylkim@knu.ac.kr;jh-cho@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0.94 | 2025-06-25 | 6 | 8 | EARLY MORTALITY; SUBOPTIMAL INITIATION; INCIDENT HEMODIALYSIS; PRACTICE PATTERNS; KIDNEY-DISEASE; OUTCOMES; PREDICTORS; COMPLICATIONS; EPIDEMIOLOGY; PREVALENCE | Humans; Kidney Failure, Chronic; Peritoneal Dialysis; Prospective Studies; Renal Dialysis; Republic of Korea; chronic kidney failure; clinical trial; epidemiology; hemodialysis; human; multicenter study; peritoneal dialysis; prospective study; South Korea | English | 2023 | 2023-04-13 | 10.1038/s41598-023-33216-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | The effects of muscle mass and quality on mortality of patients with acute kidney injury requiring continuous renal replacement therapy | This study examined the effects of muscle mass on mortality in patients with acute kidney injury requiring continuous renal replacement therapy. It was conducted in eight medical centers between 2006 and 2021. The data of 2200 patients over the age of 18 years with acute kidney injury who required continuous renal replacement therapy were retrospectively collected. Skeletal muscle areas, categorized into normal and low attenuation muscle areas, were obtained from computed tomography images at the level of the third lumbar vertebra. Cox proportional hazards models were used to investigate the association between mortality within 1, 3, and 30 days and skeletal muscle index. Sixty percent of patients were male, and the 30-day mortality rate was 52%. Increased skeletal muscle areas/body mass index was associated with decreased mortality risk. We also identified a 26% decreased risk of low attenuation muscle area/body mass index on mortality. We established that muscle mass had protective effects on the mortality of patients with acute kidney injury requiring continuous renal replacement therapy. This study showed that muscle mass is a significant determinant of mortality, even if the density is low. | Jung, Jiyun; Lee, Jangwook; Lim, Jeong-Hoon; Kim, Yong Chul; Ban, Tae Hyun; Park, Woo Yeong; Kim, Kyeong Min; Kim, Kipyo; Lee, Sung Woo; Shin, Sung Joon; Han, Seung Seok; Kim, Dong Ki; Ko, Yousun; Kim, Kyung Won; Kim, Hyosang; Park, Jae Yoon | Dongguk Univ, Clin Trial Ctr, Ilsan Hosp, Goyang, South Korea; Dongguk Univ, Res Ctr Chron Dis & Environm Med, Coll Med, Gyeongju, South Korea; Dongguk Univ, Dept Internal Med, Ilsan Hosp, Goyang, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Catholic Univ Korea, Eunpyeong St Marys Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Keimyung Univ, Dongsan Hosp, Dept Internal Med, Sch Med, Daegu, South Korea; Eulji Univ, Daejeon Eulji Med Ctr, Dept Internal Med, Daejeon, South Korea; Inha Univ, Inha Univ Hosp, Dept Internal Med, Coll Med, Incheon, South Korea; Eulji Univ, Uijeongbu Eulji Med Ctr, Dept Internal Med, Gyeonggi Do, South Korea; Dongguk Univ, Dept Internal Med, Coll Med, Gyeongju, South Korea; Asan Med Ctr, Asan Inst Life Sci, Biomed Res Ctr, Seoul, South Korea; Univ Ulsan, Asan Med Ctr, Dept Radiol, Coll Med, Seoul, South Korea; Univ Ulsan, Asan Med Ctr, Dept Internal Med, Div Nephrol,Coll Med, Seoul, South Korea | Kim, Il Young/LLK-4732-2024; Kim, Kyunghoon/AGO-0079-2022; Han, Seung/W-8825-2019; Kim, Hyungduk/CAH-5630-2022; Kim, Ho/G-2712-2011; Kim, Kyung-Min Kim/C-7007-2014; Park, Woo Yeong/AGK-9140-2022; Lim, Jeong-Hoon/ABE-6003-2020 | 57211813518; 57223232128; 55360244300; 57026583000; 56119751700; 36344980100; 57199438486; 57164118000; 56708181900; 55662651000; 35242581200; 23479259100; 56030047400; 56128365800; 57190118848; 56603383500 | mateus@amc.seoul.kr;nephrojyp@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0.47 | 2025-06-25 | 4 | 4 | SKELETAL-MUSCLE; SARCOPENIA DIAGNOSIS; FAILURE | Acute Kidney Injury; Adult; Continuous Renal Replacement Therapy; Female; Humans; Male; Middle Aged; Muscle, Skeletal; Renal Replacement Therapy; Retrospective Studies; acute kidney failure; adult; continuous renal replacement therapy; female; human; male; middle aged; procedures; renal replacement therapy; retrospective study; skeletal muscle | English | 2023 | 2023-05-05 | 10.1038/s41598-023-33716-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | The prediction of sagittal chin point relapse following two-jaw surgery using machine learning | The study aimed to identify critical factors associated with the surgical stability of pogonion (Pog) by applying machine learning (ML) to predict relapse following two-jaw orthognathic surgery (2 J-OGJ). The sample set comprised 227 patients (110 males and 117 females, 207 training and 20 test sets). Using lateral cephalograms taken at the initial evaluation (T0), pretreatment (T1), after (T2) 2 J-OGS, and post treatment (T3), 55 linear and angular skeletal and dental surgical movements (T2-T1) were measured. Six ML modes were utilized, including classification and regression trees (CART), conditional inference tree (CTREE), and random forest (RF). The training samples were classified into three groups; highly significant (HS) (>= 4), significant (S) (>= 2 and < 4), and insignificant (N), depending on Pog relapse. RF indicated that the most important variable that affected relapse rank prediction was ramus inclination (RI), CTREE and CART revealed that a clockwise rotation of more than 3.7 and 1.8 degrees of RI was a risk factor for HS and S groups, respectively. RF, CTREE, and CART were practical tools for predicting surgical stability. More than 1.8 degrees of CW rotation of the ramus during surgery would lead to significant Pog relapse. | Kim, Young Ho; Kim, Inhwan; Kim, Yoon-Ji; Ki, Minji; Cho, Jin-Hyoung; Hong, Mihee; Kang, Kyung-Hwa; Lim, Sung-Hoon; Kim, Su-Jung; Kim, Namkug; Shin, Jeong Won; Sung, Sang-Jin; Baek, Seung-Hak; Chae, Hwa Sung | Ajou Univ, Sch Med, Inst Oral Hlth Sci, Dept Orthodont, Suwon, South Korea; Univ Ulsan, Asan Med Inst Convergence Sci & Technol, Asan Med Ctr, Dept Convergence Med,Coll Med, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Orthodont, Seoul, South Korea; Ewha Womans Univ, Coll Med, Dept Orthodont, Seoul, South Korea; Chonnam Natl Univ, Sch Dent, Dept Orthodont, Gwangju, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Orthodont, Daegu 41940, South Korea; Wonkwang Univ, Sch Dent, Dept Orthodont, Iksan, South Korea; Chosun Univ, Coll Dent, Dept Orthodont, Gwangju, South Korea; Kyung Hee Univ, Sch Dent, Dept Orthodont, Seoul, South Korea; Seoul Natl Univ, Dent Res Inst, Sch Dent, Dept Orthodont, Seoul, South Korea; Chung Ang Univ, Gwangmyeong Hosp, Dept Orthodont, Gwangmyeong, South Korea | ; KIM, SUHWAN/GSE-0120-2022; Baek, Seung-Hak/NOE-8444-2025; Kim, Namkug/E-3843-2012; Sung, Sang Jin/KBQ-4217-2024 | 57207443980; 57222816092; 57221435554; 58638186800; 15764519700; 57190379016; 35285868600; 36793499100; 57039799500; 16550058300; 57210164233; 7202731963; 35090967400; 57203779388 | hwasungchae@cauhs.or.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0.47 | 2025-06-25 | 5 | 4 | LONG-TERM STABILITY | Cephalometry; Chin; Female; Follow-Up Studies; Humans; Male; Malocclusion, Angle Class III; Mandible; Maxilla; Orthognathic Surgical Procedures; Recurrence; Retrospective Studies; angle class III malocclusion; cephalometry; chin; diagnostic imaging; female; follow up; human; male; mandible; maxilla; orthognathic surgery; recurrent disease; retrospective study | English | 2023 | 2023-10-09 | 10.1038/s41598-023-44207-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | The role of dexamethasone in mediating the contradictory effects of Wnt antagonists SFRP2 and SFRP3 on human hair follicle growth | Stress can be one of the leading causes of hair loss. Stress related hormones, glucocorticoids (GCs), secretion by hair follicle have been mentioned in literature and proven to exert an inhibitory effect on hair follicle cells growth by modulating the expression of target genes related to cell proliferation and cycling. The gene modulating effect of the synthetic GC, dexamethasone (DEX), in human dermal papilla (DP) cells has been outlined in this study by mediating a contradictory effect on the expression of secreted frizzled related protein 2 (SFRP2) and SFRP3. The SFRP2 and SFRP3 possess a regulating effect on wnt signaling pathway. Their structural similarities to the cysteine-rich-domain of the frizzled receptors (FZD) allow their binding to the wnt ligands causing the blocking of the wnt ligands-receptors complex. The SFRP family members have been known as inhibitors of the wnt signaling modulating the proliferation and development of various cells. In hair follicle cells, SFRP2 activity has been reported positively on the proliferation of keratinocytes. However, the SFRP3 effect hasn't been well addressed. Under stress, the investigation of the mRNA and protein expressions of SFRP members in human DP cells revealed opposite expressions where SFRP2 decreased while SFRP3 increased by DEX. The proliferation rate of hair keratinocytes outer root sheath was detected via immunofluorescence highlighting the stimulatory effect of SFRP2 and the inhibitory effect of SFRP3. Here, we sought to determine the effect of GC agonist on SFRPs expression and their effect on hair follicle growth. | Hamida, Ons Ben; Kim, Moon Kyu; Kwack, Mi Hee | Kyungpook Natl Univ, Sch Med, Dept Immunol, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Hair Transplantat Ctr, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu, South Korea | 58628712100; 57199748390; 6507685557 | moonkim@knu.ac.kr;go3004@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0 | 2025-06-25 | 0 | 0 | CELLS; DICKKOPF-1; MODULATORS; STRESS; TARGET; SKIN | Dexamethasone; Hair; Hair Follicle; Humans; Keratinocytes; Membrane Proteins; Wnt Signaling Pathway; dexamethasone; membrane protein; SFRP2 protein, human; genetics; hair; hair follicle; human; keratinocyte; metabolism; Wnt signaling | English | 2023 | 2023-10-02 | 10.1038/s41598-023-43688-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Three-dimensional vertical structural electrochemical random access memory for high-density integrated synapse device | Three-terminal (3T) structured electrochemical random access memory (ECRAM) has been proposed as a synaptic device based on improved synaptic characteristics. However, the proposed 3T ECRAM has a larger area requirement than 2T synaptic devices; thereby limiting integration density. To overcome this limitation, this study presents the development of a high-density vertical structure for the 3T ECRAM. In addition, complementary metal-oxide semiconductor (CMOS)-compatible materials and 8-inch wafer-based CMOS fabrication processes were utilized to verify the feasibility of mass production. The achievements of this work demonstrate the potential for high-density integration and mass production of 3T ECRAM devices. | Kim, Hyejin; Seo, Jongseon; Cho, Seojin; Jeon, Seonuk; Woo, Jiyong; Lee, Daeseok | Kwangwoon Univ, Dept Elect Mat Engn, Seoul 01897, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | 57558641700; 57221853306; 58557810700; 57955098300; 53985749100; 36604679100 | leeds@kw.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0.47 | 2025-06-25 | 4 | 4 | MEMRISTOR | English | 2023 | 2023-08-31 | 10.1038/s41598-023-41202-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Transcranial focused ultrasound-mediated unbinding of phenytoin from plasma proteins for suppression of chronic temporal lobe epilepsy in a rodent model | The efficacy of many anti-epileptic drugs, including phenytoin (PHT), is reduced by plasma protein binding (PPB) that sequesters therapeutically active drug molecules within the bloodstream. An increase in systemic dose elevates the risk of drug side effects, which demands an alternative technique to increase the unbound concentration of PHT in a region-specific manner. We present a low-intensity focused ultrasound (FUS) technique that locally enhances the efficacy of PHT by transiently disrupting its binding to albumin. We first identified the acoustic parameters that yielded the highest PHT unbinding from albumin among evaluated parameter sets using equilibrium dialysis. Then, rats with chronic mesial temporal lobe epilepsy (mTLE) received four sessions of PHT injection, each followed by 30 min of FUS delivered to the ictal region, across 2 weeks. Two additional groups of mTLE rats underwent the same procedure, but without receiving PHT or FUS. Assessment of electrographic seizure activities revealed that FUS accompanying administration of PHT effectively reduced the number and mean duration of ictal events compared to other conditions, without damaging brain tissue or the blood-brain barrier. Our results demonstrated that the FUS technique enhanced the anti-epileptic efficacy of PHT in a chronic mTLE rodent model by region-specific PPB disruption. | Kim, Evgenii; Kim, Hyun-Chul; Van Reet, Jared; Boehlke, Mark; Yoo, Seung-Schik; Lee, Wonhye | Harvard Med Sch, Brigham & Womens Hosp, Dept Radiol, 75 Francis St, Boston, MA 02115 USA; Massachusetts Coll Pharm & Hlth Sci Univ, Boston, MA USA; Kyungpook Natl Univ, Dept Artificial Intelligence, Daegu, South Korea | ; Lee, Wonhye/J-5166-2016; Kim, Leehyung/AAN-6760-2020 | 59845978800; 57194876917; 57823770600; 15838830100; 7401970708; 35755741800 | wonhye@bwh.harvard.edu; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0.83 | 2025-06-25 | 7 | 8 | BOVINE SERUM-ALBUMIN; BRAIN-BARRIER DISRUPTION; KAINIC ACID INJECTION; MULTI-SPECTROSCOPY; STIMULATION; BINDING; NEUROMODULATION; SEIZURES; RATS; POTENTIALS | Animals; Anticonvulsants; Blood Proteins; Epilepsy, Temporal Lobe; Phenytoin; Rats; Rodentia; anticonvulsive agent; phenytoin; plasma protein; animal; metabolism; rat; rodent; temporal lobe epilepsy | English | 2023 | 2023-03-13 | 10.1038/s41598-023-31383-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Triphenylphosphonium conjugated gold nanotriangles impact Pi3K/AKT pathway in breast cancer cells: a photodynamic therapy approach | Although gold nanoparticles based photodynamic therapy (PDT) were reported to improve efficacy and specificity, the impact of surface charge in targeting cancer is still a challenge. Herein, we report gold nanotriangles (AuNTs) tuned with anionic and cationic surface charge conjugating triphenylphosphonium (TPP) targeting breast cancer cells with 5-aminoleuvinic acid (5-ALA) based PDT, in vitro. Optimized surface charge of AuNTs with and without TPP kill breast cancer cells. By combining, 5-ALA and PDT, the surface charge augmented AuNTs deliver improved cellular toxicity as revealed by MTT, fluorescent probes and flow cytometry. Further, the 5-ALA and PDT treatment in the presence of AuNTs impairs cell survival Pi3K/AKT signaling pathway causing mitochondrial dependent apoptosis. The cumulative findings demonstrate that, cationic AuNTs with TPP excel selective targeting of breast cancer cells in the presence of 5-ALA and PDT. | Vinita, Nadar Manimaran; Devan, Umapathy; Durgadevi, Sabapathi; Anitha, Selvaraj; Prabhu, Dhamodharan; Rajamanikandan, Sundarraj; Govarthanan, Muthusamy; Yuvaraj, Ananthanarayanan; Biruntha, Muniyandi; Antony Joseph Velanganni, Arockiam; Jeyakanthan, Jeyaraman; Prakash, Pitchan Arul; Mohamed Jaabir, Mohamed Sultan; Kumar, Ponnuchamy | Alagappa Univ, Dept Anim Hlth & Management, Food Chem & Mol Canc Biol Lab, Karaikkudi 630003, Tamil Nadu, India; Bharathidasan Univ, Dept Biochem, Mol Oncol Lab, Tiruchirappalli 620024, Tamil Nadu, India; BIHER, SBMCH, Res & Dev Wing, Chennai 600044, Tamil Nadu, India; Karpagam Acad Higher Educ, Dept Biochem, Ctr Drug Design, Coimbatore 641021, Tamil Nadu, India; Kyungpook Natl Univ, Dept Environm Engn, Deagu 41566, South Korea; Saveetha Inst Med & Tech Sci, Dept Biomat, Saveetha Dent Coll & Hosp, Chennai 600077, Tamil Nadu, India; Periyar Univ, Dept Zool, Salem 636011, Tamil Nadu, India; Alagappa Univ, Dept Bioinformat, Karaikkudi 630003, Tamil Nadu, India; Natl Coll, PG & Res Dept Biotechnol & Microbiol, Tiruchirappalli 620001, Tamil Nadu, India | Ponnuchamy, Kumar/D-3470-2013; Govarthanan, Muthusamy/C-1491-2014; S, Anitha/AAL-5756-2020; Muthusamy, Govarthanan/C-1491-2014; Prabhu, Dhamodharan/GLT-5308-2022; Yuvaraj, Ananthanarayanan/B-2040-2019; Muniyandi, BIRUNTHA/G-2438-2019 | 57211994283; 57209471851; 57209773271; 57957509000; 57190883650; 38562006800; 54881927600; 57202376867; 57203752025; 57219711804; 8885182100; 57204707431; 35774748100; 55173720800 | kumarp@alagappauniversity.ac.in; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 1.42 | 2025-06-25 | 13 | 12 | DRUG-DELIVERY; NANOPARTICLES; APOPTOSIS; PERFORMANCE; MECHANISMS; INHIBITION; EXPRESSION; SURVIVAL; RELEASE; TARGET | Aminolevulinic Acid; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Female; Gold; Humans; Metal Nanoparticles; Phosphatidylinositol 3-Kinases; Photochemotherapy; Photosensitizing Agents; Proto-Oncogene Proteins c-akt; aminolevulinic acid; gold; metal nanoparticle; phosphatidylinositol 3 kinase; photosensitizing agent; protein kinase B; apoptosis; breast tumor; female; human; photochemotherapy; tumor cell line | English | 2023 | 2023-02-08 | 10.1038/s41598-023-28678-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Visual field prediction using a deep bidirectional gated recurrent unit network model | Although deep learning architecture has been used to process sequential data, only a few studies have explored the usefulness of deep learning algorithms to detect glaucoma progression. Here, we proposed a bidirectional gated recurrent unit (Bi-GRU) algorithm to predict visual field loss. In total, 5413 eyes from 3321 patients were included in the training set, whereas 1272 eyes from 1272 patients were included in the test set. Data from five consecutive visual field examinations were used as input; the sixth visual field examinations were compared with predictions by the Bi-GRU. The performance of Bi-GRU was compared with the performances of conventional linear regression (LR) and long short-term memory (LSTM) algorithms. Overall prediction error was significantly lower for Bi-GRU than for LR and LSTM algorithms. In pointwise prediction, Bi-GRU showed the lowest prediction error among the three models in most test locations. Furthermore, Bi-GRU was the least affected model in terms of worsening reliability indices and glaucoma severity. Accurate prediction of visual field loss using the Bi-GRU algorithm may facilitate decision-making regarding the treatment of patients with glaucoma. | Kim, Hwayeong; Lee, Jiwoong; Moon, Sangwoo; Kim, Sangil; Kim, Taehyeong; Jin, Sang Wook; Kim, Jung Lim; Shin, Jonghoon; Lee, Seung Uk; Jang, Geunsoo; Hu, Yuanmeng; Park, Jeong Rye | Pusan Natl Univ, Coll Med, Dept Ophthalmol, Busan, South Korea; Pusan Natl Univ Hosp, Biomed Res Inst, Busan, South Korea; Pusan Natl Univ, Dept Math, Busan, South Korea; Dong A Univ, Coll Med, Dept Ophthalmol, Busan, South Korea; Inje Univ, Busan Paik Hosp, Coll Med, Dept Ophthalmol, Busan, South Korea; Pusan Natl Univ, Yangsan Hosp, Sch Med, Dept Ophthalmol, Yangsan, South Korea; Kosin Univ, Coll Med, Dept Ophthalmol, Busan, South Korea; Kyungpook Natl Univ, Nonlinear Dynam & Math Applicat Ctr, Daegu, South Korea; Kyungpook Natl Univ, Dept Math, 80 Daehak ro, Daegu 41566, South Korea | Lee, Jiwoong/AAA-5837-2022; Jin, Sangwook/HLW-0610-2023; Kim, taehyeong/AAC-4335-2022; Kim, SOOCHI/AAD-6959-2020; KIM, SUNG/ADF-8559-2022; Park, Jeong Rye/MDS-8129-2025 | 57219125703; 56031087100; 57219335649; 34978723300; 57216457235; 56048687000; 54398894600; 36912100400; 57203301114; 57471384400; 58479367000; 56471031400 | parkjr@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 1.53 | 2025-06-25 | 10 | 13 | GRU NETWORK; GLAUCOMA; PROGRESSION; RELIABILITY | Algorithms; Eye; Glaucoma; Humans; Reproducibility of Results; Visual Fields; algorithm; eye; glaucoma; human; reproducibility; visual field | English | 2023 | 2023-07-10 | 10.1038/s41598-023-37360-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | WOx channel engineering of Cu-ion-driven synaptic transistor array for low-power neuromorphic computing | The multilevel current states of synaptic devices in artificial neural networks enable next-generation computing to perform cognitive functions in an energy-efficient manner. Moreover, considering large-scale synaptic arrays, multiple states programmed in a low-current regime may be required to achieve low energy consumption, as demonstrated by simple numerical calculations. Thus, we propose a three-terminal Cu-ion-actuated CuOx/HfOx/WO3 synaptic transistor array that exhibits analogously modulated channel current states in the range of tens of nanoamperes, enabled by WO3 channel engineering. The introduction of an amorphous stoichiometric WO3 channel formed by reactive sputtering with O gas significantly lowered the channel current but left it almost unchanged with respect to consecutive gate voltage pulses. An additional annealing process at 450 degrees C crystallized the WO3, allowing analog switching in the range of tens of nanoamperes. The incorporation of N gas during annealing induced a highly conductive channel, making the channel current modulation negligible as a function of the gate pulse. Using this optimized gate stack, Poole-Frenkel conduction was identified as a major transport characteristic in a temperature-dependent study. In addition, we found that the channel current modulation is a function of the gate current response, which is related to the degree of progressive movement of the Cu ions. Finally, the synaptic characteristics were updated using fully parallel programming and demonstrated in a 7 x 7 array. Using the CuOx/HfOx/WO3 synaptic transistors as weight elements in multilayer neural networks, we achieved a 90% recognition accuracy on the Fashion-MNIST dataset. | Jeon, Seonuk; Kang, Heebum; Kwak, Hyunjeong; Noh, Kyungmi; Kim, Seungkun; Kim, Nayeon; Kim, Hyun Wook; Hong, Eunryeong; Kim, Seyoung; Woo, Jiyong | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Pohang Univ Sci & Technol, Dept Mat Sci & Engn, Pohang 37673, South Korea | 57955098300; 57232405900; 57203745904; 57326724000; 58634750300; 59884547500; 57557016000; 57556070800; 57211871375; 53985749100 | jiyong.woo@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0.59 | 2025-06-25 | 5 | 5 | copper ion; article; artificial neural network; controlled study; electric potential; energy consumption; nerve cell network; pharmaceutics; reactive sputtering; temperature; transistor | English | 2023 | 2023-12-13 | 10.1038/s41598-023-49251-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | YWHAZ and TBP are potential reference gene candidates for qPCR analysis of response to radiation therapy in colorectal cancer | The expression profiles of conventional reference genes (RGs), including ACTB and GAPDH, used in quantitative real-time PCR (qPCR), vary depending on tissue types and environmental conditions. We searched for suitable RGs for qPCR to determine the response to radiotherapy in colorectal cancer (CRC) cell lines, organoids, and patient-derived tissues. Ten CRC cell lines (Caco-2, COLO 205, DLD-1, HCT116, HCT-15, HT-29, RKO, SW1116, SW480, and SW620) and organoids were selected and irradiated with 2, 10 or 21 grays (Gy) based on the previous related studies conducted over the last decade. The expression stability of 14 housekeeping genes (HKGs; ACTB, B2M, G6PD, GAPDH, GUSB, HMBS, HPRT1, IPO8, PGK1, PPIA, TBP, TFRC, UBC, and YWHAZ) after irradiation was evaluated using RefFinder using raw quantification cycle (Cq) values obtained from samples before and after irradiation. The expression stability of HKGs were also evaluated for paired fresh frozen tissues or formalin-fixed, paraffin-embedded samples obtained from CRC patients before and after chemoradiotherapy. The expression of YWHAZ and TBP encoding 14-3-3-zeta protein and TATA-binding protein were more stable than the other 12 HKGs in CRC cell lines, organoids, and patient-derived tissues after irradiation. The findings suggest that YWHAZ and TBP are potential RG candidates for normalizing qPCR results in CRC radiotherapy experiments. | Kim, Shin; Park, Jee Young; Lee, Hye Won; Bae, Sung Uk; Kim, Kyeong Eui; Byun, Sang Jun; Seo, Incheol | Keimyung Univ, Dept Immunol, Sch Med, Daegu, South Korea; Keimyung Univ, Inst Canc Res, Daegu, South Korea; Keimyung Univ, Inst Med Sci, Daegu, South Korea; Keimyung Univ, Dept Pathol, Dongsan Med Ctr, Daegu, South Korea; Keimyung Univ, Dept Surg, Dongsan Med Ctr, Daegu, South Korea; Keimyung Univ, Dept Radiat Oncol, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Immunol, 680 Gukchaebosang Ro, Daegu 41944, South Korea | Park, Jung Hwan/AAA-1951-2022; Kim, Shin/D-1669-2013; Bae, Sung/W-1915-2019 | 57210866288; 59871973400; 57907713300; 55748167300; 57743294300; 55446661100; 56022683900 | kryph@dsmc.or.kr;iseo@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 13 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 3.8 | 18.3 | 0.47 | 2025-06-25 | 4 | 4 | SUITABLE REFERENCE GENES; HOUSEKEEPING GENES; EXPRESSION; NORMALIZATION; CELLS; PCR; IDENTIFICATION; STABILITY; GAPDH | 14-3-3 Proteins; Caco-2 Cells; Colorectal Neoplasms; Gene Expression Profiling; Genes, Essential; Humans; Real-Time Polymerase Chain Reaction; Reference Standards; protein 14 3 3; YWHAZ protein, human; Caco-2 cell line; colorectal tumor; essential gene; gene expression profiling; genetics; human; procedures; real time polymerase chain reaction; standard | English | 2023 | 2023-08-09 | 10.1038/s41598-023-39488-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Information Provision, Decision Self-efficacy, and Decisional Conflict in Adopting Health Behaviors Among Patients Treated for Colorectal Cancer A Cross-sectional Study | BackgroundHealth promotion is necessary to mitigate the negative consequences of colorectal cancer and its treatment. Rates of behavior modification are low in populations of cancer patients. Studies are needed to determine the factors, such as decisional conflict, which influence adoption of healthy behaviors following a cancer diagnosis.ObjectiveTo examine the effects of information provision, decision self-efficacy, and decisional conflict on the adoption of healthy behaviors among patients with colorectal cancer.MethodsThis cross-sectional study focused on 251 patients with colorectal cancer in South Korea. Information provision, decision self-efficacy, and decisional conflict were measured using validated instruments. Patients rated their decisional conflict related to the adoption of behaviors that include regular exercise and a balanced diet.ResultsMost participants (73%) reported low satisfaction with the amount of information received. Of the participants, 64% had low decision self-efficacy, and 80% experienced decisional conflict. The perception of a higher level of information provision was associated with greater decision self-efficacy (odds ratio, 4.63; 95% confidence interval, 1.61-13.35). Higher decision self-efficacy was associated with lower decisional conflict (odds ratio, 5.19; 95% confidence interval, 2.33-11.59).ConclusionReceiving adequate information is important for promoting patients' confidence in making decisions about their health and reducing decisional conflict in the adoption of healthy lifestyle changes following a cancer diagnosis.Implication for PracticeOncology nurses should assess patient information needs and promote decision self-efficacy, thus empowering patients diagnosed with colorectal cancer to make lifestyle decisions that improve their health and quality of life. | Lee, Myung Kyung; Bryant-Lukosius, Denise | Kyungpook Natl Univ, Res Inst Nursing Sci, Coll Nursing, Daegu, South Korea; McMaster Univ, Canadian Ctr Adv Practice Nursing Res, Sch Nursing, Hamilton, ON, Canada; McMaster Univ, Dept Oncol, Canadian Ctr Adv Practice Nursing Res, Hamilton, ON, Canada; Res Inst Nursing Sci, Coll Nursing, 680 Gukchabosangro, Daegu 41944, South Korea | 40661513200; 8095565000 | mlee@knu.ac.kr;bryantl@mcmaster.ca; | CANCER NURSING | CANCER NURS | 0162-220X | 1538-9804 | 46 | 1 | SCIE;SSCI | NURSING;ONCOLOGY | 2023 | 2.4 | 18.4 | 2.29 | 2025-06-25 | 9 | 11 | Cancer; Decisional conflict; Decision making; Decision self-efficacy; Information provision | QUALITY-OF-LIFE; PHYSICAL-ACTIVITY; PROSTATE-CANCER; DIAGNOSIS; ASSOCIATION; SURVIVORS; DISEASE; STYLE; STAGE; RISK | Cancer; Decision making; Decision self-efficacy; Decisional conflict; Information provision | Colorectal Neoplasms; Conflict, Psychological; Cross-Sectional Studies; Decision Making; Health Behavior; Humans; Quality of Life; Self Efficacy; antineoplastic agent; aged; Article; colorectal cancer; conflict; controlled study; cross-sectional study; diet; exercise; female; health behavior; healthy lifestyle; human; major clinical study; male; medical information; patient decision making; patient satisfaction; self concept; sociodemographics; South Korea; colorectal tumor; decision making; health behavior; quality of life | English | 2023 | 2023 (JAN-FEB) | 10.1097/ncc.0000000000001040 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Constant Association between Low High-Density Lipoprotein Cholesterol and Gastric Cancer Regardless of Site | Background: Some epidemiologic factors and body mass index (BMI) have site-specific effects on gastric cancer. The site-specific effect of high-density lipoprotein cholesterol (HDL-C) and hyperglycemia on gastric cancer has not been reported.Methods: This study included adults who underwent national gastric cancer screening in 2011 (n=5.49 million). The validation set included gastric cancer patients (n=3,262) and gastric cancer-free persons who underwent health screening (n=14,121) in a single hospital. The site-specific effects of metabolic components and epidemiologic factors on gastric cancer were investigated.Results: Among 5.49 million individuals, 10,417 gastric cancer cases (6,764 non-cardiac gastric cancer [NCGC] and 152 cardiac gastric cancer [CGC]) were detected. BMI was inversely associated with NCGC (P for trend <0.001) but not with CGC. Low HDL-C was associated with both CGC (adjusted odds ratio [aOR], 1.90; 95% confidence interval [CI], 1.34 to 2.71) and NCGC (aOR, 1.41; 95% CI, 1.34 to 1.49). Fasting glucose & GE;110 mg/dL was associated with NCGC (aOR, 1.19) and CGC (aOR, 1.50). Men predominance was larger in CGC (aOR, 3.28) than in NCGC (aOR, 1.98). Smoking, alcohol drinking, and family history were associated with NCGC but not with CGC. In the validation set, low HDL-C was associated with CGC (aOR, 2.80) and NCGC (aOR, 2.32). BMI was inversely associated with NCGC (P for trend <0.001), and hyperglycemia was positively associated with both NCGC and CGC.Conclusion: Many epidemiologic factors had site-specific effects on gastric cancer, whereas low HDL-C and hyperglycemia were constantly associated with gastric cancer regardless of the site in two independent sets. | Nam, Su Youn; Jeong, Jihyeon; Jeon, Seong Woo | Kyungpook Natl Univ, Chilgok Hosp, Dept Gastroenterol, Daegu, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Gastroenterol, 807 Hoguk-ro, Daegu 41404, South Korea | Jeon, Seongwoo/AAU-4618-2020 | 55617028500; 57209972988; 9733636500 | nam20131114@gmail.com; | JOURNAL OF OBESITY & METABOLIC SYNDROME | J OBES METAB SYNDR | 2508-6235 | 2508-7576 | 32 | 2 | ESCI | ENDOCRINOLOGY & METABOLISM | 2023 | 4.7 | 18.5 | 0.53 | 2025-06-25 | 3 | 3 | Stomach neoplasms; Location; Lipoproteins; Body mass index; Hyperglycemia | BODY-MASS INDEX; COLORECTAL-CANCER; RISK; POPULATION; INSULIN; ADENOCARCINOMA; METAANALYSIS; EXERCISE; GHRELIN | Body mass index; Hyperglycemia; Lipoproteins; Location; Stomach neoplasms | glucose; high density lipoprotein cholesterol; adult; alcohol consumption; Article; body mass; cancer patient; cancer screening; confidence interval; controlled study; disease association; family history; female; glucose blood level; heart; human; hyperglycemia; major clinical study; male; mass screening; middle aged; odds ratio; smoking; stomach cancer | English | 2023 | 2023-06 | 10.7570/jomes22045 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The Task Decomposition and Dedicated Reward-System-Based Reinforcement Learning Algorithm for Pick-and-Place | This paper proposes a task decomposition and dedicated reward-system-based reinforcement learning algorithm for the Pick-and-Place task, which is one of the high-level tasks of robot manipulators. The proposed method decomposes the Pick-and-Place task into three subtasks: two reaching tasks and one grasping task. One of the two reaching tasks is approaching the object, and the other is reaching the place position. These two reaching tasks are carried out using each optimal policy of the agents which are trained using Soft Actor-Critic (SAC). Different from the two reaching tasks, the grasping is implemented via simple logic which is easily designable but may result in improper gripping. To assist the grasping task properly, a dedicated reward system for approaching the object is designed through using individual axis-based weights. To verify the validity of the proposed method, wecarry out various experiments in the MuJoCo physics engine with the Robosuite framework. According to the simulation results of four trials, the robot manipulator picked up and released the object in the goal position with an average success rate of 93.2%. | Kim, Byeongjun; Kwon, Gunam; Park, Chaneun; Kwon, Nam Kyu | Yeungnam Univ, Dept Elect Engn, Gyongsan 38541, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea | 58421740900; 58421741000; 57001658700; 55902868000 | slim7928@ynu.ac.kr;nineman@yu.ac.kr;chaneun@knu.ac.kr;namkyu@yu.ac.kr; | BIOMIMETICS | BIOMIMETICS-BASEL | 2313-7673 | 8 | 2 | SCIE | ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, BIOMATERIALS | 2023 | 3.4 | 18.5 | 0.5 | 2025-06-25 | 4 | 4 | deep reinforcement learning; Soft Actor-Critic; Pick-and-Place; task decomposition; robot manipulator | ROBOTS | deep reinforcement learning; Pick-and-Place; robot manipulator; Soft Actor-Critic; task decomposition | English | 2023 | 2023-06 | 10.3390/biomimetics8020240 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | Weight Loss Prediction after Metabolic and Bariatric Surgery | Metabolic/bariatric surgery is currently the most effective measure to treat morbid obesity and obesity-related comorbidities such as type 2 diabetes. It has proven effective not only in terms of short-term weight loss, but also in maintaining the lower body weight for several decades. Such weight loss improves patient quality of life and extends life expectancy. It is crucial for patients to understand the likely results of a given bariatric procedure so that they can make an informed decision about whether to undergo surgery. The amount of weight loss after metabolic/bariatric surgery is usually the most important outcome of interest to patients considering surgical treatment. It is also the most common primary endpoint for healthcare providers. Patients undergoing surgery want tangible and realistic expectations about how much weight they could lose after surgery, and healthcare professionals need to determine at each follow-up visit after surgery whether patients are on track to reach their weight loss target so they can provide timely intervention to patients with insufficient weight loss or weight re-gain. Weight loss after metabolic/bariatric surgery is influenced by many clinical variables, including initial body mass index, age, gender, ethnicity, and type of surgery. A well-validated chronological weight loss prediction model would enable patient-centered counseling and goal setting. This review summarizes and compares sev-eral publicly available prediction models. | Park, Ji Yeon | Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea; Kyungpook Natl Univ, Dept Surg, Chilgok Hosp, 807 Hoguk Ro, Daegu 41404, South Korea | Park, Ji Yeon/AAV-2471-2020 | 57196405216 | jybark99@hanmail.net; | JOURNAL OF OBESITY & METABOLIC SYNDROME | J OBES METAB SYNDR | 2508-6235 | 2508-7576 | 32 | 1 | ESCI | ENDOCRINOLOGY & METABOLISM | 2023 | 4.7 | 18.5 | 1.23 | 2025-06-25 | 17 | 16 | Bariatric surgery; Obesity; morbid; Weight loss | Y GASTRIC BYPASS; LAPAROSCOPIC SLEEVE GASTRECTOMY; CONVENTIONAL MEDICAL THERAPY; BINGE-EATING DISORDER; CLINICAL FACTORS; LOSS OUTCOMES; ASSOCIATION | Bariatric surgery; morbid; Obesity; Weight loss | age; bariatric surgery; body mass; body weight gain; body weight loss; diabetes mellitus; ethnicity; follow up; human; mental disease; prediction; Review | English | 2023 | 2023-03 | 10.7570/jomes23008 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Vacuum-powered soft actuator with oblique air chambers for easy detachment of artificial dry adhesive by coupled contraction and twisting | A gecko foot-inspired, mushroom-shaped artificial dry adhesive exploiting intermolecular forces between microstructure and surface has drawn research attention for its strong adhesive force. However, the high pull-off strength corresponding to the adhesive force matters when detaching fragile substrates. In this study, we report a vacuum-powered soft actuator having oblique air chambers and a dry adhesive. The soft actuator performs coupled contraction and twisting by applying negative pneumatic pressure inward and exhibits not only high pull-off strength but also easy detachment. This effective detachment can be achieved thanks to the twisting motion of the soft actuator. The detachment performances of the actuator models are assessed using a 6-degrees-of-freedom robot arm. Results show that the soft actuators exhibit remarkable pull-off strength decrement from similar to 20 N cm(-2) to similar to 2 N cm(-2) due to the twisting. Finally, to verify a feasible application of this study, we utilize the inherent compliance of the actuators and introduce a glass transfer system for which a glass substrate on a slope is gripped by the flexibility of the soft actuators and delivered to the destination without any fracture. [GRAPHICS] . | Yoo, Seung Hoon; Kim, Minsu; Park, Han Jun; Lee, Ga In; Lee, Sung Ho; Kwak, Moon Kyu | Kyungpook Natl Univ, Dept Mech Engn, Daegu, South Korea; Dong A Univ, Dept Mech Engn, Busan, South Korea; Kyungpook Natl Univ, Dept Mech Engn, Daegu 41566, South Korea; Dong A Univ, Dept Mech Engn, Busan 49315, South Korea | Kwak, Moon/F-2786-2012; Yoo, Seung-Hoon/F-1048-2010 | 57871736100; 57212315616; 57455185400; 58184185700; 56195582600; 57203947984 | sunghol@dau.ac.kr;mkkwak@knu.ac.kr; | SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS | SCI TECHNOL ADV MAT | 1468-6996 | 1878-5514 | 24 | 1 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2023 | 7.4 | 18.6 | 0.52 | 2025-06-25 | 5 | 5 | Soft actuator; dry adhesive; gecko; robot arm; glass transportation systems | FABRICATION; SURFACES; ROBOTICS; DESIGN | dry adhesive; gecko; glass transportation systems; robot arm; Soft actuator | Adhesives; Chemical bonds; Compliance control; Glass substrates; Robotic arms; Adhesive force; Air chambers; Dry adhesive; Gecko; Gecko feet; Glass transportation system; Pull off strengths; Robot arms; Soft actuators; Transportation system; Glass | English | 2023 | 2023-12-31 | 10.1080/14686996.2023.2274818 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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