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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Finite horizon portfolio selection problem with a drawdown constraint on consumption | In this paper we investigate the consumption and portfolio selection problem of a finitely-lived agent who faces drawdown constraint on consumption: the agent does not accept falling in her consumption below a fixed proportion of the historically highest level. We utilize the dual martingale method and study the dual problem, which can be transformed into an infinite series of optimal stopping problems. Based on a theory of partial differential equation (PDE), we analytically characterize a variational inequality arising from the optimal stopping problem. We provide a verification theorem that the value function for the original agent's problem is the Legendre-Fenchel transform of the integral of the value functions for the optimal stopping problems. Moreover, we derive integral equation representations for the optimal strategies and provide some numerical implications for the optimal strategies. (c) 2021 Elsevier Inc. All rights reserved. | Jeon, Junkee; Oh, Jehan | Kyung Hee Univ, Dept Appl Math, Yongin, South Korea; Kyung Hee Univ, Inst Nat Sci, Yongin, South Korea; Kyungpook Natl Univ, Dept Math, Daegu, South Korea | 57056929900; 56673305300 | junkeejeon@khu.ac.kr;jehan.oh@knu.ac.kr; | JOURNAL OF MATHEMATICAL ANALYSIS AND APPLICATIONS | J MATH ANAL APPL | 0022-247X | 1096-0813 | 506 | 1 | SCIE | MATHEMATICS, APPLIED;MATHEMATICS | 2022 | 1.3 | 25.3 | 1.19 | 2025-06-25 | 7 | 7 | Drawdown constraint; Optimal consumption and; investment; Singular control problem; Variational inequality; Free boundary | Drawdown constraint; Free boundary; Optimal consumption and investment; Singular control problem; Variational inequality | English | 2022 | 2022-02-01 | 10.1016/j.jmaa.2021.125542 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Infinitely many segregated vector solutions of Schrodinger system | We consider the following system of Schrodinger equations {-Delta U + lambda U = alpha U-0(3) + beta UV2 -Delta V + mu(y)V = alpha V-1(3) + beta(UV)-V-2 in R-N, N = 2, 3, where lambda, alpha(0), alpha(1)> 0 are positive constants, beta is an element of R is the coupling constant, and mu : R-N -> R is a potential function. Continuing the work of Lin and Peng [6], we present a solution of the type where one species has a peak at the origin and the other species has many peaks over a circle, but as seen in the above, coupling terms are nonlinear. (C) 2022 Elsevier Inc. All rights reserved. | Kwon, Ohsang; Lee, Min-Gi; Lee, Youngae | Chungbuk Natl Univ, Dept Math, Cheongju, South Korea; Kyungpook Natl Univ, Dept Math, Daegu, South Korea; Ulsan Natl Inst Sci & Technol UNIST, Coll Nat Sci, Dept Math Sci, Ulsan, South Korea | Lee, Youngae/GPG-2128-2022 | 57218663165; 36704125500; 58239646700 | ohsangkwon@chungbuk.ac.kr;leem@knu.ac.kr;youngaelee@unist.ac.kr; | JOURNAL OF MATHEMATICAL ANALYSIS AND APPLICATIONS | J MATH ANAL APPL | 0022-247X | 1096-0813 | 512 | 2 | SCIE | MATHEMATICS, APPLIED;MATHEMATICS | 2022 | 1.3 | 25.3 | 0.34 | 2025-06-25 | 2 | 2 | Coupled Schrodinger system; Segregation; Vector solution; Distribution of bump; Energy expansion | POSITIVE SOLUTIONS; EQUATIONS | Coupled Schrodinger system; Distribution of bump; Energy expansion; Segregation; Vector solution | English | 2022 | 2022-08-15 | 10.1016/j.jmaa.2022.126094 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Correction | Photoacoustic tomography with line detector: Exact inversion formula (vol 500, 125119, 2021) | Kim, Juyeon; Moon, Sunghwan; Hristova, Yulia | Kyungpook Natl Univ, Coll Nat Sci, Dept Math, Daegu 41566, South Korea; Univ Michigan, Dept Math & Stat, Dearborn, MI 48128 USA | 57222359278; 56063426100; 25624736700 | sunghwan.moon@knu.ac.kr; | JOURNAL OF MATHEMATICAL ANALYSIS AND APPLICATIONS | J MATH ANAL APPL | 0022-247X | 1096-0813 | 506 | 2 | SCIE | MATHEMATICS, APPLIED;MATHEMATICS | 2022 | 1.3 | 25.3 | 0 | 2025-06-25 | 0 | 0 | English | 2022 | 2022-02-15 | 10.1016/j.jmaa.2021.125655 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Anti-Itching and Anti-Inflammatory Effects of Kushenol F via the Inhibition of TSLP Production | Atopic dermatitis (AD) is a chronic inflammatory skin disease that results from eczema, itching, disrupted barrier function and aberrant cutaneous immune responses. The aim of the present study was to assess the efficacy of kushenol F as an effective treatment for AD via the suppression of thymic stromal lymphopoietin (TSLP) production. The results of the present study demonstrated that the clinical symptoms of AD were less severe and there was reduced ear thickening and scratching behavior in kushenol F-treated Dermatophagoides farinae extract (DFE)/1-chloro-2,4-dinitrochlorobenzene (DNCB)-induced AD mice. Histopathological analysis demonstrated that kushenol F decreased the DFE/DNCB-induced infiltration of eosinophil and mast cells and TSLP protein expression levels. Furthermore, kushenol F-treated mice exhibited significantly lower concentrations of serum histamine, IgE and IgG2a compared with the DFE/DNCB-induced control mice. Kushenol F also significantly decreased phosphorylated NF-kappa B and IKK levels and the mRNA expression levels of IL-1 beta and IL-6 in cytokine combination-induced human keratinocytes. The results of the present study suggested that kushenol F may be a potential therapeutic candidate for the treatment of AD via reducing TSLP levels. | Jo, Seongyea; Gong, Eun-Yeung; Yoo, Wonbeak; Choi, Hyunji; Jung, Dana; Noh, Kyung Hee; Kim, Seokho; Kim, Sang-Hyun; Lee, Hyeong-Kyu | Korea Res Inst Biosci & Biotechnol, Ind Biomat Res Ctr, Daejeon 34141, South Korea; Korea Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Lab Stem Cell & Tissue Generat, Sci Campus, Seoul 02481, South Korea; Dong A Univ, Dept Med Biotechnol, Coll Hlth Sci, Busan 49315, South Korea; Korea Res Inst Biosci & Biotechnol, Environm Dis Res Ctr, Daejeon 34141, South Korea; Korea Res Inst Biosci & Biotechnol, Daejeon 34141, South Korea; Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu 41944, South Korea; Korea Res Inst Biosci & Biotechnol, Nat Med Res Ctr, Cheongju 28116, South Korea | Yoo, Wonbeak/HTO-6919-2023 | 57190687792; 7005376870; 57220705444; 56970043100; 57211230583; 57207703348; 59783437700; 57210450420; 16240660700 | cvaccine@dau.ac.kr;shkim72@knu.ac.kr;hykylee@kribb.re.kr; | PHARMACEUTICALS | PHARMACEUTICALS-BASE | 1424-8247 | 15 | 11 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2022 | 4.6 | 25.4 | 0.61 | 2025-06-25 | 4 | 6 | kushenol F; atopic dermatitis; thymic stromal lymphopoietin (TSLP); itching; inflammation | THYMIC STROMAL LYMPHOPOIETIN; MEDIATED ALLERGIC INFLAMMATION; NF-KAPPA-B; ATOPIC-DERMATITIS; SOPHORA-FLAVESCENS; SOPHORAFLAVANONE G; EXPRESSION; KERATINOCYTES; INSIGHTS; PATHOGENESIS | atopic dermatitis; inflammation; itching; kushenol F; thymic stromal lymphopoietin (TSLP) | 1 chloro 2 4 dinitrochlorobenzene; chemical agent; chemical compound; cytokine; dust mite extract; flagellin; I kappa B kinase; immunoglobulin E; immunoglobulin G2a; interleukin 13; interleukin 1beta; interleukin 4; interleukin 6; kushenol F; thymic stromal lymphopoietin; tumor necrosis factor; unclassified drug; animal experiment; animal model; anti Inflammatory effect; anti Itching effect; Article; atopic dermatitis; behavior; biochemical analysis; blood biochemistry; blood sampling; cell culture; cell infiltration; cell viability; chemical procedures; controlled study; drug activity; enzyme linked immunosorbent assay; eosinophil; female; hematological parameters; histamine blood level; histology; histopathology; human; human cell; immunohistochemistry; in vivo study; keratinocyte; liquid chromatography-mass spectrometry; mast cell; mouse; mRNA expression level; MTT assay; NF kB signaling; nonhuman; nuclear magnetic resonance spectroscopy; protein expression; reverse transcription polymerase chain reaction; scratching behavior; thymic stromal lymphopoietin production; Western blotting | English | 2022 | 2022-11 | 10.3390/ph15111347 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Appropriateness of antibiotic prescriptions during hospitalization and ambulatory care: a multicentre prevalence survey in Korea | Objectives: Antimicrobial resistance is one of the most urgent global health threats. The need for the qualitative evaluation of antibiotic use at the national level is increasing. To identify areas for improvement, we aimed to assess the prevalence and appropriateness of antibiotic prescriptions during hospitalization and ambulatory care in Korea.Methods: The prevalence and appropriateness of antibiotic prescriptions on 29 August 2018 were assessed for 20 hospitals in Korea. Infectious disease specialists determined appropriateness. Except for antiviral and anti-tuberculosis agents, all antibacterial or antifungal agent prescriptions during hospitalization or ambulatory care were evaluated.Results: The prevalence of antibiotic prescription was 14.1% (8,400/59 216 patients) on the study date. Antibiotics were prescribed for 50.8% of inpatients (6557/12 902), with two or more antibiotics prescribed for 27.4% (1798/6557) of patients. A total of 10 948 prescriptions (7999 therapeutic, 2105 surgical prophylaxes, and 844 medical prophylaxes) were included in the final analysis, and 27.7% of these were inappropriate. Surgical prophylaxis was inadequately prescribed most frequently (54.4%), followed by medical prophylaxis (29.5%) and therapeutic antibiotics (20.5%). The most common indications for therapeutic antibiotics were respiratory (29.1%, n = 2332), gastrointestinal (22.4%, n = 1791), and urinary tract infec-tions (13.1%, n = 1050). The most frequently prescribed antibiotics were cephalosporins (52.0%, n = 5490), followed by beta lactam/beta lactamase inhibitors (13.7%, n = 1373), fluoroquinolones (9.1%, n = 957), and metronidazole (6.6%, n = 699).Conclusion: This was the first nationwide qualitative antibiotic prescription adequacy evaluation in Korea. A significant proportion of antibiotic prescriptions were inappropriate. Therefore, interventions for high-frequency infections and prescription antibiotics are needed.(c) 2022 The Author(s). Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ) | Park, Se Yoon; Moon, Song Mi; Kim, Bongyoung; Lee, Myung Jin; Park, Ji Young; Hwang, Soyoon; Yu, Shi Nae; Lee, Yu-Mi; Lee, Ho Jin; Hong, Kyung-Wook; Park, Kyung-Hwa; Kwak, Yee Gyung; Moon, Chisook; Jeon, Min Hyok; Park, Sun Hee; Kim, Young Keun; Song, Kyoung-Ho; Kim, Eu Suk; Kim, Tae Hyong; Kim, Hong Bin | Soonchunhyang Univ, Coll Med, Dept Internal Med, Div Infect Dis,Seoul Hosp, Seoul, South Korea; Yonsei Univ, Dept Hosp Med, Yongin Severance Hosp, Coll Med, Yongin, South Korea; Yonsei Univ Hlth Syst, Yongin Severance Hosp, Ctr Digital Hlth, Yongin, South Korea; Seoul Natl Univ, Coll Med, Dept Internal Med, Div Infect Dis,Bundang Hosp, Seongnam, South Korea; Hanyang Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Inje Univ, Dept Internal Med, Sanggye Paik Hosp, Seoul, South Korea; Chung Ang Univ Hosp, Dept Pediat, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Chilgok Hosp, Sch Med, Dept Internal Med,Div Infect Dis, Daegu, South Korea; Soonchunhyang Univ, Coll Med, Dept Internal Med, Cheonan Hosp, Cheonan, South Korea; Kyung Hee Univ, Kyung Hee Univ Hosp, Dept Internal Med, Div Infect Dis,Sch Med, Seoul, South Korea; Dong A Univ, Div Infect Dis, Coll Med, Pusan, South Korea; Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Dept Internal Med, Coll Med, Jinju, South Korea; Chonnam Natl Univ, Chonnam Natl Univ Hosp, Dept Infect Dis, Med Sch, Gwangju, South Korea; Inje Univ, Dept Internal Med, Ilsan Paik Hosp, Goyang, South Korea; Inje Univ, Dept Infect Dis, Busan Paik Hosp, Pusan, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Div Infect Dis, Seoul, South Korea; Yonsei Univ, Wonju Severance Christian Hosp, Dept Internal Med, Wonju Coll Med, Wonju, South Korea; Soonchunhyang Univ, Dept Internal Med, Seoul Hosp, Coll Med, 59 Daesagwan Ro,Yongsan Gu, Seoul, South Korea | Kim, Woo/AAG-1822-2019; Kim, Young/H-4235-2013; Park, Ji Young/KDO-4256-2024; Hong, Kyung-Wook/T-3067-2018; Hwang, Soyoon/HHM-5762-2022; Kim, Eu/J-5424-2012; Kim, Hee/AAU-6368-2021; Kim, Hong Bin/J-5452-2012 | 55259986400; 36554757200; 55622077200; 55520467500; 57022396700; 57203160675; 57203755478; 57203798842; 55706782600; 38461203300; 57219637574; 7103120454; 22980995800; 10439278500; 57208684295; 35322538300; 23398486700; 22938086900; 55927274000; 35307429400 | geuncom@schmc.ac.kr;hbkimmd@snu.ac.kr; | JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE | J GLOB ANTIMICROB RE | 2213-7165 | 2213-7173 | 29 | SCIE | INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY | 2022 | 4.6 | 25.4 | 1.63 | 2025-06-25 | 19 | 18 | Point prevalence survey; Appropriateness; Anti-bacterial agents; Antibiotic prophylaxis; Bacterial infection | Anti-bacterial agents; Antibiotic prophylaxis; Appropriateness; Bacterial infection; Point prevalence survey | Ambulatory Care; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Drug Prescriptions; Hospitalization; Humans; Prevalence; Republic of Korea; aminoglycoside antibiotic agent; antibiotic agent; beta lactam antibiotic; beta lactamase inhibitor; carbapenem; cefazedone; cefazolin; ceftriaxone; cephalosporin derivative; flomoxef; glycopeptide; lincosamide; macrolide; metronidazole; monobactam derivative; oxazolidinone derivative; penicillin derivative; piperacillin plus tazobactam; polymyxin; quinoline derived antiinfective agent; rifampicin; sulfonamide; tetracycline derivative; tigecycline; trimethoprim; antiinfective agent; adult; ambulatory care; antibiotic prophylaxis; Article; bacteremia; cardiovascular infection; central nervous system infection; controlled study; cross-sectional study; drug indication; febrile neutropenia; female; gastrointestinal infection; hospitalization; human; infectious disease specialist; Korea; major clinical study; male; musculoskeletal infection; otitis media; prescribing error; prescription; prevalence; protozoal infection; respiratory tract infection; sexually transmitted disease; skin infection; soft tissue infection; tick borne disease; urinary tract infection; ambulatory care; clinical trial; epidemiology; hospitalization; multicenter study; South Korea | English | 2022 | 2022-06 | 10.1016/j.jgar.2022.03.021 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Chalcone: A Promising Bioactive Scaffold in Medicinal Chemistry | Chalcones are a class of privileged scaffolds with high medicinal significance due to the presence of an alpha,beta-unsaturated ketone functionality. Numerous functional modifications of chalcones have been reported, along with their pharmacological behavior. The present review aims to summarize the structures from natural sources, synthesis methods, biological characteristics against infectious and non-infectious diseases, and uses of chalcones over the past decade, and their structure-activity relationship studies are detailed in depth. This critical review provides guidelines for the future design and synthesis of various chalcones. In addition, this could be highly supportive for medicinal chemists to develop more promising candidates for various infectious and non-infectious diseases. | Rajendran, Gayathri; Bhanu, Deepu; Aruchamy, Baladhandapani; Ramani, Prasanna; Pandurangan, Nanjan; Bobba, Kondapa Naidu; Oh, Eun Jung; Chung, Ho Yun; Gangadaran, Prakash; Ahn, Byeong-Cheol | Amrita Vishwa Vidyapeetham, Dept Sci, Dhanvanthri Lab, Amrita Sch Phys Sci, Coimbatore 641112, Tamil Nadu, India; Amrita Vishwa Vidyapeetham, Amrita Sch Engn, Ctr Excellence Adv Mat & Green Technol CoE AMGT, Coimbatore 641112, Tamil Nadu, India; Amrita Vishwa Vidyapeetham, Dept Sci, Amrita Sch Arts & Sci, Mysuru Campus, Mysuru 570026, India; Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Plast & Reconstruct Surg,CMRI, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Nucl Med, Daegu 41944, South Korea | ; Ramani, Prasanna/ABZ-7862-2022; Gangadaran, Prakash/AAV-3102-2021 | 58108087300; 58108087400; 57265189600; 55761773500; 56338977800; 56902497500; 35746789300; 7404007181; 54393130400; 7202791511 | r_prasanna1@cb.amrita.edu;abc2000@knu.ac.kr; | PHARMACEUTICALS | PHARMACEUTICALS-BASE | 1424-8247 | 15 | 10 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2022 | 4.6 | 25.4 | 2.9 | 2025-06-25 | 74 | 77 | chalcones; natural sources; Claisen-Schmidt condensation; infectious diseases; non-infectious diseases; structure-activity relationship | CLAISEN-SCHMIDT CONDENSATION; TRIAZOLE-LINKED CHALCONE; INDOLE-BASED CHALCONES; BIOLOGICAL EVALUATION; IN-VITRO; ANTICANCER ACTIVITY; ANTIBACTERIAL ACTIVITY; ANGELICA-KEISKEI; POTENTIAL ANTIMALARIAL; METHOXYLATED CHALCONES | chalcones; Claisen–Schmidt condensation; infectious diseases; natural sources; non-infectious diseases; structure–activity relationship | adiponectin; antiparkinson agent; chalcone; Glycyrrhiza glabra root; imidazole; indole; molecular scaffold; pyrimidine; thiazole; tuberculostatic agent; Alpinia; Alzheimer disease; Angelica keiskei; antibacterial activity; antidiabetic activity; antifungal activity; antimalarial activity; antineoplastic activity; antiviral activity; breast cancer; chemical reaction; chemical structure; colon cancer; diabetes mellitus; liver cell carcinoma; lung cancer; malaria; Mallotus philippinensis; medicinal chemistry; microwave radiation; non communicable disease; nonhuman; ovary carcinoma; oxidative stress; pancreas carcinoma; prostate cancer; Review; structure activity relation; synthesis; tuberculosis; ultrasound; uterine cervix cancer | English | 2022 | 2022-10 | 10.3390/ph15101250 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Discovery of Kinase and Carbonic Anhydrase Dual Inhibitors by Machine Learning Classification and Experiments | A multi-target small molecule modulator is advantageous for treating complicated diseases such as cancers. However, the strategy and application for discovering a multi-target modulator have been less reported. This study presents the dual inhibitors for kinase and carbonic anhydrase (CA) predicted by machine learning (ML) classifiers, and validated by biochemical and biophysical experiments. ML trained by CA I and CA II inhibitor molecular fingerprints predicted candidates from the protein-specific bioactive molecules approved or under clinical trials. For experimental tests, three sulfonamide-containing kinase inhibitors, 5932, 5946, and 6046, were chosen. The enzyme assays with CA I, CA II, CA IX, and CA XII have allowed the quantitative comparison in the molecules' inhibitory activities. While 6046 inhibited weakly, 5932 and 5946 exhibited potent inhibitions with 100 nM to 1 mu M inhibitory constants. The ML screening was extended for finding CAs inhibitors of all known kinase inhibitors. It found XMU-MP-1 as another potent CA inhibitor with an approximate 30 nM inhibitory constant for CA I, CA II, and CA IX. Differential scanning fluorimetry confirmed the direct interaction between CAs and small molecules. Cheminformatics studies, including docking simulation, suggest that each molecule possesses two separate functional moieties: one for interaction with kinases and the other with CAs. | Kim, Min-Jeong; Pandit, Sarita; Jee, Jun-Goo | Kyungpook Natl Univ, Pharmaceut Sci Res Inst, Coll Pharm, 80 Daehak ro, Daegu 41566, South Korea | 57215818497; 57458852000; 7004327823 | dns01185@naver.com;saritapandit94@gmail.com;jjee@knu.ac.kr; | PHARMACEUTICALS | PHARMACEUTICALS-BASE | 1424-8247 | 15 | 2 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2022 | 4.6 | 25.4 | 0.1 | 2025-06-25 | 1 | 1 | carbonic anhydrase; cheminformatics; docking simulation; dual inhibitor; fingerprint; kinase; machine learning; polypharmacology | SMALL-MOLECULE INHIBITORS; ACCURATE DOCKING; PREDICTION; BINDING; DRUGS; DATABASE; POLYPHARMACOLOGY; IDENTIFICATION; LIGANDS; ANALOGS | Carbonic anhydrase; Cheminformatics; Docking simulation; Dual inhibitor; Fingerprint; Kinase; Machine learning; Polypharmacology | acetazolamide; carbonate dehydratase I; carbonate dehydratase II; carbonate dehydratase inhibitor; carbonate dehydratase IX; carbonate dehydratase XII; casein kinase; cyclin dependent kinase 2; diclofenamide; ethoxzolamide; hydrochlorothiazide; hydroflumethiazide; jnj 7706621; methazolamide; pazopanib; phosphotransferase inhibitor; protein kinase Syk; sulfonamide; sulpiride; unclassified drug; valdecoxib; xmu mp 1; zinc 13804313; zinc 28127722; zinc 28389402; zinc 28470844; zonisamide; Article; Bayesian learning; binding affinity; cheminformatics; controlled study; decision tree; drug potency; drug protein binding; drug screening; drug structure; drug targeting; enzyme inhibition; extreme gradient boosting; IC50; inhibition constant; k nearest neighbor; logistic regression analysis; machine learning; measurement accuracy; molecular docking; molecular fingerprinting; multilayer perceptron; prediction; random forest; receiver operating characteristic | English | 2022 | 2022-02 | 10.3390/ph15020236 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Identification of Angiogenic Cargoes in Human Fibroblasts-Derived Extracellular Vesicles and Induction of Wound Healing | A complete redevelopment of the skin remains a challenge in the management of acute and chronic wounds. Recently, the application of extracellular vesicles (EVs) for soft tissue wound healing has received much attention. As fibroblasts are fundamental cells for soft tissues and skin, we investigate the proangiogenic factors in human normal fibroblast-derived EVs (hNF-EVs) and their effects on wound healing. Normal fibroblasts were isolated from human skin tissues and characterized by immunofluorescence (IF) and Western blotting (WB). hNF-EVs were isolated by ultracentrifugation and characterized using transmission electron microscopy and WB. The proangiogenic cargos in hNF-EVs were identified by a TaqMan assay and a protein array. Other in vitro assays, including internalization assays, cell counting kit-8 analysis, scratch wound assays, WBs, and tube formation assays were conducted to assess the effects of hNF-EVs on fibroblasts and endothelial cells. A novel scaffold-free noninvasive delivery of hNF-EVs with or without fibrin glue was applied onto full-thickness skin wounds in mice. The wound healing therapeutical effect of hNF-EVs was assessed by calculating the rate of wound closure and through histological analysis. Isolated hNF was confirmed by verifying the expression of the fibroblast markers vimentin, alpha SMA, Hsp70, and S100A4. Isolated hNF-EVs showed intact EVs with round morphology, enriched in CD81 and CD63, and devoid of the cell markers GM130, Calnexin, and Cytochrome C. Our TaqMan assay showed that hNF-EVs were enriched in miR130a and miR210, and protein arrays showed enriched levels of the proangiogenic proteins' vascular endothelial growth factor (VEGF)-D and CXCL8. Next, we found that the internalization of hNF-EVs into hNF increased the proliferation and migration of hNF, in addition to increasing the expression of bFGF, MMP2, and alpha SMA. The internalization of hNF-EVs into the endothelial cells increased their proliferation and tube formation. A scaffold-free noninvasive delivery of hNF-EVs with or without fibrin glue accelerated the wound healing rate in full-thickness skin wounds in mice, and the treatments increased the cellular density, deposition, and maturation of collagens in the wounds. Moreover, the scaffold-free noninvasive delivery of hNF-EVs with or without fibrin glue increased the VEGF and CD31 expression in the wounds, indicating that hNF-EVs have an angiogenic ability to achieve complete skin regeneration. These findings open up for new treatment strategies to be developed for wound healing. Further, we offer a new approach to the efficient, scaffold-free noninvasive delivery of hNF-EVs to wounds. | Gangadaran, Prakash; Oh, Eun Jung; Rajendran, Ramya Lakshmi; Kim, Hyun Mi; Oh, Ji Min; Kwak, Suin; Hong, Chae Moon; Choi, Kang Young; Chung, Ho Yun; Ahn, Byeong-Cheol | Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Plast & Reconstruct Surg, CMRI,Sch Med, Daegu 41944, South Korea | ; Rajendran, Ramya/AAV-6338-2021; Gangadaran, Prakash/AAV-3102-2021 | 54393130400; 35746789300; 57195318729; 57261065200; 57190370462; 57735418300; 37050876700; 57203745682; 7404007181; 7202791511 | prakashg@knu.ac.kr;fullrest74@knu.ac.kr;ramyag@knu.ac.kr;sarang7939@naver.com;ojm0366@knu.ac.kr;suin8349@naver.com;cmhong@knu.ac.kr;kychoi@knu.ac.kr;hy-chung@knu.ac.kr;abc2000@knu.ac.kr; | PHARMACEUTICALS | PHARMACEUTICALS-BASE | 1424-8247 | 15 | 6 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2022 | 4.6 | 25.4 | 1.21 | 2025-06-25 | 12 | 12 | fibroblasts; extracellular vesicles; miRNAs; wound healing; angiogenesis | MESENCHYMAL STEM-CELLS; SMOOTH MUSCLE ACTIN; IN-VIVO; MATRIX METALLOPROTEINASES; PROLIFERATION; MIGRATION; EXOSOMES; EXPRESSION; MICRORNA | angiogenesis; extracellular vesicles; fibroblasts; miRNAs; wound healing | alpha smooth muscle actin; angiogenic factor; biological marker; calnexin; calvasculin; CD63 antigen; CD81 antigen; collagen; complementary DNA; cytochrome c; fibroblast growth factor 2; gelatinase A; heat shock protein 70; interleukin 8; microRNA; microRNA 130a; microRNA 210; monocyte chemotactic protein 1; platelet endothelial cell adhesion molecule 1; unclassified drug; vasculotropin; vimentin; angiogenesis; animal experiment; animal model; antiangiogenic activity; Article; bioassay; cell culture; cell isolation; cell migration; cell migration assay; cell proliferation; cell proliferation assay; cell structure; endothelium cell; exosome; extracellular vesicles labeling and Internalization assay; female; fibroblast; fibrogenesis; histology; human; human cell; immunofluorescence; immunofluorescence assay; immunohistochemistry; in vitro study; internalization assay; mouse; nonhuman; plasma skin regeneration; protein expression; protein microarray; real time polymerase chain reaction; skin culture; TaqMan assay; transmission electron microscopy; tubulogenesis; ultracentrifugation; Western blotting; wound closure; wound healing; wound healing assay | English | 2022 | 2022-06 | 10.3390/ph15060702 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Lineage Differentiation Potential of Different Sources of Mesenchymal Stem Cells for Osteoarthritis Knee | Tissue engineering and regenerative medicine (TERM) have paved a way for treating musculoskeletal diseases in a minimally invasive manner. The regenerative medicine cocktail involves the usage of mesenchymal stem/stromal cells (MSCs), either uncultured or culture-expanded cells along with growth factors, cytokines, exosomes, and secretomes to provide a better regenerative milieu in degenerative diseases. The successful regeneration of cartilage depends on the selection of the appropriate source of MSCs, the quality, quantity, and frequency of MSCs to be injected, and the selection of the patient at an appropriate stage of the disease. However, confirmation on the most favorable source of MSCs remains uncertain to clinicians. The lack of knowledge in the current cellular treatment is uncertain in terms of how beneficial MSCs are in the long-term or short-term (resolution of pain) and improved quality of life. Whether MSCs treatments have any superiority, exists due to sources of MSCs utilized in their potential to objectively regenerate the cartilage at the target area. Many questions on source and condition remain unanswered. Hence, in this review, we discuss the lineage differentiation potentials of various sources of MSCs used in the management of knee osteoarthritis and emphasize the role of tissue engineering in cartilage regeneration. | Prajwal, Gollahalli Shivashankar; Jeyaraman, Naveen; Kanth, Krishna, V; Jeyaraman, Madhan; Muthu, Sathish; Rajendran, Sree Naga Sowndary; Rajendran, Ramya Lakshmi; Khanna, Manish; Oh, Eun Jung; Choi, Kang Young; Chung, Ho Yun; Ahn, Byeong-Cheol; Gangadaran, Prakash | Dr Ram Manohar Lohiya Natl Law Univ, Fellowship Orthopaed Rheumatol FEIORA, Lucknow 226010, Uttar Pradesh, India; Indian Stem Cell Study Grp ISCSG Assoc, Lucknow 110048, Uttar Pradesh, India; Mallika Spine Ctr, Dept Orthopaed, Guntur 522001, Andhra Pradesh, India; Atlas Hosp, Dept Orthopaed, Tiruchirappalli 620002, Tamil Nadu, India; Govt Med Coll, Dept Orthopaed, Mahabubabad 506104, Telangana, India; Sri Lalithambigai Med Coll & Hosp, Dr MGR Educ & Res Inst, Dept Orthopaed, Fac Med, Chennai 600095, Tamil Nadu, India; Sharda Univ, Sch Engn & Technol, Dept Biotechnol, Greater Noida 201306, Uttar Pradesh, India; Orthopaed Res Grp, Coimbatore 641001, Tamil Nadu, India; Sri Venkateshwaraa Med Coll Hosp & Res Ctr, Dept Med, Pondicherry 605102, India; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Govt Med Coll & Hosp, Dept Orthopaed, Dindigul 624001, Tamil Nadu, India; Prasad Inst Med Sci, Dept Orthopaed, Lucknow 226010, Uttar Pradesh, India; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Plast & Reconstruct Surg,CMRI, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu 41944, South Korea | Gangadaran, Prakash/AAV-3102-2021; KRISHNA KANTH, V/GQH-6909-2022; Muthu, Sathish/G-5756-2018; Rajendran, Ramya/AAV-6338-2021; Jeyaraman, Madhan/ABB-8464-2020 | 57226062500; 57219306833; 57563753300; 57216926503; 57217850874; 57432957800; 57195318729; 57220576074; 35746789300; 57203745682; 7404007181; 7202791511; 54393130400 | prajwalgs1894@gmail.com;naveenjeyaraman@yahoo.com;krishna_kanth42@yahoo.com;madhanjeyaraman@gmail.com;drsathishmuthu@gmail.com;sowndaryasreeraj8@gmail.com;ramyag@knu.ac.kr;manishvenus@rediffmail.com;fullrest74@hanmail.net;kychoi@knu.ac.kr;hy-chung@knu.ac.kr;abc2000@knu.ac.kr;prakashg@knu.ac.kr; | PHARMACEUTICALS | PHARMACEUTICALS-BASE | 1424-8247 | 15 | 4 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2022 | 4.6 | 25.4 | 0.39 | 2025-06-25 | 11 | 10 | mesenchymal stem cells; chondrogenesis; tissue engineering; cartilage; osteoarthritis | HUMAN DENTAL-PULP; BONE-MARROW; HEMATOPOIETIC STEM; OSTEOGENIC DIFFERENTIATION; PERIPHERAL-BLOOD; ADIPOSE-TISSUE; CHONDROGENIC DIFFERENTIATION; STROMAL CELLS; IN-VITRO; REGENERATIVE MEDICINE | cartilage; chondrogenesis; mesenchymal stem cells; osteoarthritis; tissue engineering | cytokine; growth factor; adipose-derived mesenchymal stem cell; amniotic fluid cell; bone marrow mesenchymal stem cell; cell differentiation; cell lineage; clinical effectiveness; dental tissue derived mesenchymal stem cell; endometrium derived mesenchymal stem cell; exosome; hematopoietic stem cell; human; induced pluripotent stem cell; knee osteoarthritis; mesenchymal stem cell; mesenchymal stem cell transplantation; mesenchymal stroma cell; nonhuman; outcome assessment; periosteum derived mesenchymal stem cell; peripheral blood stem cell; quality of life; regenerative medicine; Review; secretome; stem cell; synovium derived mesenchymal stem cell; tissue engineering | English | 2022 | 2022-04 | 10.3390/ph15040386 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Modeling of Intelligent Sensor Duty Cycling for Smart Home Automation | The advancement of wireless sensor networks (WSNs) improves various smart home automation services and home users' living standards. However, efficiently collecting data and automating smart home services require the extensive deployment of the sensors. Thus, one of the crucial and challenging tasks is to minimize the sensors' energy consumption for monitoring and automating various activities in a smart home. In this article, we present a solution to control the excessive energy consumption of sensors used to detect various activities of daily living (ADL) of a smart home resident. The sensors within a smart home network are divided into various groups employing the recurrent neural network (RNN) and dynamic time warping (DTW) techniques to predict the activities with high accuracy and less energy consumption. The smart home users' future activities are forecast with bidirectional long short-term memory (BLSTM) RNN model to select those sensors that are likely to predict the upcoming activities. Similarly, to predict the home users' unusual activities, a guard sensor is elected among sensors with high similarities with each other using DTW. The sensor's role is evenly switched between different modes to maintain a fair tradeoff between energy and accuracy. An extensive set of simulations is performed to validate the proposed scheme's work integrating datasets from authentic sources. Finally, the proposed system significantly reduces the sensors' energy consumption and prolongs the battery lifetime to approximately 137 days. | Khan, Murad; Seo, Junho; Kim, Dongkyun | Kyungpook Natl Univ, Sch Comp Sci, Daegu 41566, South Korea | Khan, Turyalai/HPH-0061-2023 | 56151971600; 57208740581; 35753648800 | mkhan@knu.ac.kr;jhseo@knu.ac.kr;dongkyun@knu.ac.kr; | IEEE TRANSACTIONS ON AUTOMATION SCIENCE AND ENGINEERING | IEEE T AUTOM SCI ENG | 1545-5955 | 1558-3783 | 19 | 3 | SCIE | AUTOMATION & CONTROL SYSTEMS | 2022 | 5.6 | 25.4 | 0.98 | 2025-06-25 | 8 | 14 | Sensors; Intelligent sensors; Smart homes; Wireless sensor networks; Energy consumption; Batteries; Hidden Markov models; Duty cycling; home automation; recurrent neural networks (RNNs); smart homes; wireless sensor networks (WSNs) | SENTRY SELECTION; WIRELESS; NETWORKS | Duty cycling; home automation; recurrent neural networks (RNNs); smart homes; wireless sensor networks (WSNs) | Automation; Bayesian networks; Brain; Electric batteries; Energy efficiency; Energy utilization; Forecasting; Intelligent buildings; Duty-cycling; Dynamic time warping; Energy; Energy-consumption; High-accuracy; Home automation; Home users; Recurrent neural network; Smart homes; Wireless sensor network; Wireless sensor networks | English | 2022 | 2022-07 | 10.1109/tase.2021.3084631 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Physiological Tremor Filtering Without Phase Distortion for Robotic Microsurgery | All existing physiological tremor filtering algorithms, developed for robotic microsurgery, use nonlinear phase prefilters to isolate the tremor signal. Such filters cause phase distortion to the filtered tremor signal and limit the filtering accuracy. We revisited this long-standing problem to enable filtering of the physiological tremor without any phase distortion. We developed a combined estimation-prediction paradigm that offers zero-phase type filtering. The estimation is achieved with the mathematically modified recursive singular spectrum analysis algorithm, and the prediction is delivered with the standard extreme learning machine. In addition, to limit the computational cost, we developed two moving window versions of this structure, which are appropriate for real-time implementation. The proposed paradigm preserved the natural phase of the filtered tremor. It achieved the key performance index of error limitation below 10 mu m, yielding the estimation accuracy larger than 70%, at a time delay of 36 ms only. Both moving window versions of the proposed approach restricted the computational cost considerably while offering the same performance. It is the first time that the effective estimation of the physiological tremor is achieved, without any prefiltering and phase distortion. This proposed method is feasible for real-time implantation. Clinical translation of the proposed paradigm can significantly enhance the outcome in hand-held surgical robotics. Note to Practitioners-The imprecision caused by physiological hand tremor in microsurgeries has motivated researchers to innovate an efficient tremor compensating technique that can improve surgical performance. Yet, all the existing tremor filtering algorithms, implemented in hand-held surgical instruments, use nonlinear phase prefilters to separate the tremor signal. The inherent phase distortion caused by such prefilters restricts the filtering performance significantly and renders the existing methods inadequate for hand-held robotic surgery. Motivated by this, we proposed a novel estimator-predictor-based framework, by adopting the modified recursive singular spectrum analysis estimator and the extreme learning machine predictor. The proposed framework filters the tremor signal accurately, without distorting it, but at a small fixed lag. In a set of rigorous testing performed by emulating real-time processing, the proposed algorithm showed higher performance compared with the state-of-the-art algorithms. This validates not only its suitability for real-time implantation but also its potential to improve surgical performance, which has been limited by the distorted filtering. Nonetheless, we have presented a proof-of-principle framework for distortion-free filtering, but its full implementation in a real surgical instrument, such as Micron or ITrem, requires a substantial amount of experimental testing and verification. It can be also applicable in a wide range of areas, including health-care, digital manufacturing, smart automation and control, and various other robotic technologies where efficient filtering of advanced sensor data is highly desirable. In the future, we will develop the multidimensional model of the proposed framework to enable filtering of tremor in the xyz-axes simultaneously. | Adhikari, Kabita; Tatinati, Sivanagaraja; Veluvolu, Kalyana C.; Chambers, Jonathon A. | Newcastle Univ, Sch Engn, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England; Nanyang Technol Univ, Sch Elect & Elect Engn, Singapore 639798, Singapore; Kyungpook Natl Univ, Sch Elect Engn, Daegu 702701, South Korea | Tatinati, Sivanagaraja/D-5729-2011; Veluvolu, Kalyana Chakravarthy/C-6366-2011; Adhikari, Kabita/JGG-6936-2023; Veluvolu, Kalyana/C-6366-2011 | 56808983400; 54947284700; 8703318200; 7402475745 | kabita.adhikari@newcastle.ac.uk; | IEEE TRANSACTIONS ON AUTOMATION SCIENCE AND ENGINEERING | IEEE T AUTOM SCI ENG | 1545-5955 | 1558-3783 | 19 | 1 | SCIE | AUTOMATION & CONTROL SYSTEMS | 2022 | 5.6 | 25.4 | 0.76 | 2025-06-25 | 11 | 12 | Extreme learning machine (ELM); physiological tremor; recursive singular spectrum analysis (RSSA); robotic microsurgery | EXTREME LEARNING-MACHINE; MULTISTEP PREDICTION; SENSING SYSTEM; HAND MOTION; COMPENSATION; DESIGN | Extreme learning machine (ELM); physiological tremor; recursive singular spectrum analysis (RSSA); robotic microsurgery | Machine learning; Physiology; Real time control; Robotics; Signal distortion; Signal processing; Spectrum analysis; Surgery; Clinical translation; Computational costs; Extreme learning machine; Filtering accuracies; Filtering algorithm; Key performance index; Real-time implementations; Singular spectrum analysis; Robotic surgery | English | 2022 | 2022-01 | 10.1109/tase.2020.3041427 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The Synthesis, Characterization, Molecular Docking and In Vitro Antitumor Activity of Benzothiazole Aniline (BTA) Conjugated Metal-Salen Complexes as Non-Platinum Chemotherapeutic Agents | Here, we describe the synthesis, characterization, and in vitro biological evaluation of a series of transition metal complexes containing benzothiazole aniline (BTA). We employed BTA, which is known for its selective anticancer activity, and a salen-type Schiff-based ligand to coordinate several transition metals to achieve selective and synergistic cytotoxicity. The compounds obtained were characterized by NMR spectroscopy, mass spectrometry, Fourier transform infrared spectroscopy, and elemental analysis. The compounds L, MnL, FeL, CoL, and ZnL showed promising in vitro cytotoxicity against cancer cells, and they had a lower IC50 than that of the clinically used cisplatin. In particular, MnL had synergistic cytotoxicity against liver, breast, and colon cancer cells. Moreover, MnL, CoL, and CuL promoted the production of reactive oxygen species in HepG2 tumor cell lines. The lead compound of this series, MnL, remained stable in physiological settings, and docking results showed that it interacted rationally with the minor groove of DNA. Therefore, MnL may serve as a viable alternative to platinum-based chemotherapy. | Islam, Md. Kamrul; Ha, Seongmin; Baek, Ah-Rum; Yang, Byeong-Woo; Kim, Yeoun-Hee; Park, Hyun-Jin; Kim, Minsup; Nam, Sung-Wook; Lee, Gang-Ho; Chang, Yongmin | Kyungpook Natl Univ, Inst Biomed Engn Res, 680,Gukchaebosang ro, Daegu 41944, South Korea; R&D Ctr Etnova Therapeut Corp, 124,Sagimakgol ro, Seongnam Si 13207, South Korea; InCerebro Drug Discovery Inst, Seoul 01811, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, 680,Gukchaebosang ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Chem, 80,Daehak ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Med & Biol Engn, 80,Daehak ro, Daegu 41566, South Korea; Kyungpook Natl Univ Hosp, Dept Radiol, 130 Dongdeok ro, Daegu 41944, South Korea | Nam, Sung-Wook/V-5519-2019; Yang, Byeong Woo/HII-8624-2022; Islam, Md. Kamrul/AAE-3221-2021; Islam, Md Kamrul/AAE-3221-2021; Park, Hyun-Jin/HPE-8152-2023 | 57193930944; 57239556900; 57194601711; 57195807615; 57576538700; 57203526784; 56122945800; 16167127700; 7404851841; 7501840633 | mkislam2008@yahoo.com;zx996574@gmail.com;baxun@naver.com;byungwoo1128@naver.com;bigeye38@naver.com;phj0808@etnova.co.kr;minsupkim.bio@gmail.com;nams@knu.ac.kr;ghlee@knu.ac.kr;ychang@knu.ac.kr; | PHARMACEUTICALS | PHARMACEUTICALS-BASE | 1424-8247 | 15 | 6 | SCIE | CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2022 | 4.6 | 25.4 | 0.71 | 2025-06-25 | 7 | 7 | benzothiazole aniline; transition metals; salen ligands; DNA; anticancer; Schiff-based | CANCER-THERAPY; DNA; 2-(4-AMINOPHENYL)BENZOTHIAZOLES; POTENT; CELLS; NEUROTOXICITY; COPPER | anticancer; benzothiazole aniline; DNA; salen ligands; Schiff-based; transition metals | aniline; antiinfective agent; antineoplastic agent; benzothiazole; carbon monoxide; cisplatin; copper; insulin; lead; lipid; manganese; metal complex; n (4 benzothiazole 2 yl phenyl) 2,3 bis [(2 hydroxy benzylidene) amino] propionamide; nickel; protein; reactive oxygen metabolite; selenium; transferrin; unclassified drug; zinc; animal cell; antineoplastic activity; antiproliferative activity; Article; breast adenocarcinoma cell line; breast cancer; cancer cell; cell metabolism; cell viability assay; chemotherapy; colon cancer; controlled study; cytotoxicity; cytotoxicity assay; drug synthesis; Fourier transform infrared spectroscopy; Hep-G2 cell line; HT-29 cell line; human; human cell; liver cell carcinoma; mass spectrometry; MCF-7 cell line; molecular docking; mouse; nonhuman; nuclear magnetic resonance spectroscopy; proton nuclear magnetic resonance; ultraviolet visible spectroscopy | English | 2022 | 2022-06 | 10.3390/ph15060751 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Meeting Abstract | Intense ALK5 inhibition facilitates progression and metastasis of mouse melanoma | Jeonghwan, Yoon; Bae, Eunjin; Lee, Inkyu; Han, Jinsoo; Ju, Jihyun; Kuroda, Masahiko; Mamura, Mizuko | Tokyo Med Univ, Dept Mol Pathol, Tokyo, Japan; Kyungpook Natl Univ Hosp, Biomed Res Inst, Daegu, South Korea; Konkuk Univ, Lab Anim Med, Coll Vet Med, Seoul, South Korea; Catholic Univ, St Mary Hosp, Dept Rheumatol, Seoul, South Korea | CANCER SCIENCE | CANCER SCI | 1347-9032 | 1349-7006 | 113 | SCIE | ONCOLOGY | 2022 | 5.7 | 25.5 | 0 | English | 2022 | 2022-02 | 바로가기 | 바로가기 | |||||||||||||||||
| ○ | Meeting Abstract | Linker-phosphorylated SMAD2 induces resistance to tyrosine kinase inhibition in EGFR-mutated lung adenocarcinoma | Eunjin, Bae; Yoon, Jeonghwan; Makino, Yojiro; Tamura, Atsumi; Lee, Inkyu; Han, Jinsoo; Ju, Jihyun; Sukeda, Aoi; Nagao, Toshitaka; Ohira, Tatsuo; Ikeda, Norihiko; Miyazawa, Keiji; Kato, Mitsuyasu; Kuroda, Masahiko; Mamura, Mizuko | Tokyo Med Univ, Dept Mol Pathol, Tokyo, Japan; Kyungpook Natl Univ Hosp, Biomed Res Inst, Daegu, South Korea; Konkuk Univ, Coll Vet Med, Lab Anim Med, Seoul, South Korea; Tokyo Med Univ, Dept Surg, Tokyo, Japan; Catholic Univ, Dept Rheumatol, St Mary Hosp, Seoul, South Korea; Tokyo Med Univ, Dept Anat Pathol, Tokyo, Japan; Univ Yamanashi, Dept Biochem, Kofu, Yamanashi, Japan; Univ Tsukuba, Dept Expt Pathol, Grad Sch Comprehens Human Sci, Tsukuba, Ibaraki, Japan; Univ Tsukuba, Fac Med, Tsukuba, Ibaraki, Japan | MIYAZAWA, KEIJI/I-9713-2014 | CANCER SCIENCE | CANCER SCI | 1347-9032 | 1349-7006 | 113 | SCIE | ONCOLOGY | 2022 | 5.7 | 25.5 | 0 | English | 2022 | 2022-02 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | Meeting Abstract | REGULATION OF MDM2 E3 LIGASE-DEPENDENT VASCULAR CALCIFICATION BY MSX1/2 | Kwon, D. -H.; Choe, N.; Shin, S.; Ryu, J.; Lee, Y.; Jeong, A.; Lee, Y. -G.; Kim, E. -M.; Kim, Y. -K.; Kook, H. | Chonnam Natl Univ, Sch Med, Pharmacol, Hwasun, South Korea; Kyungpook Natl Univ, Coll Pharm, Daegu, South Korea; Chonnam Natl Univ, Sch Med, Biochem, Hwasun, South Korea | ATHEROSCLEROSIS | ATHEROSCLEROSIS | 0021-9150 | 1879-1484 | 355 | SCIE | CARDIAC & CARDIOVASCULAR SYSTEMS;PERIPHERAL VASCULAR DISEASE | 2022 | 5.3 | 25.7 | 0 | English | 2022 | 2022-08 | 바로가기 | 바로가기 |
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