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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Characteristics of long COVID and the impact of COVID-19 vaccination on long COVID 2 years following COVID-19 infection: prospective cohort study | This prospective cohort study aimed to identify characteristics of long COVID and any potential mitigating effects of COVID-19 vaccinations in patients 24 months following COVID-19 infection. Adult patients diagnosed with COVID-19 between February 17, 2020, and March 24, 2020, were scheduled to visit the study hospital four times (6, 12, 18, and 24 months after infection) to assess their symptoms, quality of life, and mental health. Among the 235 patients, 121 (51.5%) completed the study visits. Of these, 59.5% were female, with a median age of 52 years. Mild to moderate disease severity were identified in 101 (83.4%) patients. A total of 75 participants (62.0%) were still experiencing long COVID symptoms 24 months after acute infection. Fatigue, amnesia, difficulty concentrating, and insomnia were the most common symptoms. The frequency of neuropsychiatric symptoms did not differ based on vaccination status or the number of doses received. Quality of life improved over time for the participants, but 32.2% of respondents still reported anxiety/depression at the end of the study. Overall, our cohort demonstrates that long COVID can persist up to 24 months after COVID-19 infection, affecting mental health and quality of life. | Kim, Yoonjung; Bae, Sohyun; Chang, Hyun-Ha; Kim, Shin-Woo | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Internal Med, Sch Med,Div Infect Dis, 130 Dongdeok Ro, Daegu 41944, South Korea | ; Kim, Ji Hoon/AAB-4602-2022; Kim, Sooyeon/AAA-8521-2022 | 57203160508; 57219699506; 7407521688; 57189703358 | ksw2kms@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 6.13 | 2025-05-07 | 15 | 17 | Adult; COVID-19; COVID-19 Vaccines; Female; Humans; Male; Middle Aged; Post-Acute COVID-19 Syndrome; Prospective Studies; Quality of Life; Vaccination; SARS-CoV-2 vaccine; adult; coronavirus disease 2019; female; human; long COVID; male; middle aged; prospective study; quality of life; vaccination | English | 2024 | 2024-01-09 | 10.1038/s41598-023-50024-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Characterization of TGFβ1-induced tendon-like structure in the scaffold-free three-dimensional tendon cell culture system | The biological mechanisms regulating tenocyte differentiation and morphological maturation have not been well-established, partly due to the lack of reliable in vitro systems that produce highly aligned collagenous tissues. In this study, we developed a scaffold-free, three-dimensional (3D) tendon culture system using mouse tendon cells in a differentially adherent growth channel. Transforming Growth Factor-beta (TGF beta) signaling is involved in various biological processes in the tendon, regulating tendon cell fate, recruitment and maintenance of tenocytes, and matrix organization. This known function of TGF beta signaling in tendon prompted us to utilize TGF beta 1 to induce tendon-like structures in 3D tendon constructs. TGF beta 1 treatment promoted a tendon-like structure in the peripheral layer of the constructs characterized by increased thickness with a gradual decrease in cell density and highly aligned collagen matrix. TGF beta 1 also enhanced cell proliferation, matrix production, and morphological maturation of cells in the peripheral layer compared to vehicle treatment. TGF beta 1 treatment also induced early tenogenic differentiation and resulted in sufficient mechanical integrity, allowing biomechanical testing. The current study suggests that this scaffold-free 3D tendon cell culture system could be an in vitro platform to investigate underlying biological mechanisms that regulate tenogenic cell differentiation and matrix organization. | Koo, Bon-hyeock; Lee, Yeon-Ju; Park, Na Rae; Heo, Su Chin; Hudson, David M.; Fernandes, Aysel A.; Friday, Chet S.; Hast, Michael W.; Corr, David T.; Keene, Douglas R.; Tufa, Sara F.; Dyment, Nathaniel A.; Joeng, Kyu Sang | Univ Penn, Perelman Sch Med, Dept Orthopaed Surg, McKay Orthopaed Res Lab, Philadelphia, PA 19104 USA; BioBricks Co Ltd, Res & Dev Div, Pohang 37673, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Mol Med, Daegu 41944, South Korea; Univ Washington, Dept Orthopaed & Sports Med, Seattle, WA 98195 USA; Rensselaer Polytech Inst, Ctr Modeling Simulat & Imaging Med CeMSIM, Dept Biomed Engn, Troy, NY 12180 USA; Shriners Childrens, Microimaging Ctr, Portland, OR 97239 USA | Dyment, Nathaniel/AAD-6747-2021 | 57200570109; 59000732600; 24492053700; 35233308000; 7202892777; 57223219499; 58000343500; 57090260900; 57210675224; 7006115456; 15741844300; 36068831700; 36828282800 | joeng@pennmedicine.upenn.edu; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0.82 | 2025-05-07 | 3 | 4 | IN-VITRO; TGF-BETA; DIFFERENTIATION; SCLERAXIS; FATE; REGENERATION; TENOMODULIN; EXPRESSION; REPAIR | Animals; Cell Culture Techniques; Cell Culture Techniques, Three Dimensional; Cell Differentiation; Cell Proliferation; Cells, Cultured; Collagen; Extracellular Matrix; Mice; Tendons; Tenocytes; Tissue Engineering; Transforming Growth Factor beta1; collagen; transforming growth factor beta1; animal; cell culture; cell culture technique; cell differentiation; cell proliferation; cytology; drug effect; extracellular matrix; metabolism; mouse; procedures; tendon; tenocyte; three dimensional cell culture; tissue engineering | English | 2024 | 2024-04-25 | 10.1038/s41598-024-60221-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Comparative associations of MASLD and MAFLD with the presence and severity of coronary artery calcification | We aimed to compare the associations of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated fatty liver disease (MAFLD) with coronary artery calcification (CAC). Patients who simultaneously underwent ultrasonography to diagnose hepatic steatosis and cardiac computed tomography to detect CAC were included. The presence and severity of CAC were defined with CAC-score thresholds of > 0 and > 300, respectively, and patients were divided into the following groups: no MASLD or MAFLD (reference), MASLD-only, MAFLD-only, and overlapping groups. Overall, 1,060/2,773 (38.2%) patients had CAC, of which 196 (18.5%) had severe CAC. The MASLD and MAFLD prevalence rates were 32.6% and 45.2%, respectively, with an overlap of 30.7%. In an ASCVD risk score-adjusted model, both MASLD (adjusted odd ratios [aOR], 1.21; 95% confidence interval [CI], 1.02-1.44; p = 0.033) and MAFLD (aOR 1.20; 95% CI 1.01-1.42, p = 0.034) were associated with CAC, whereas only MASLD (aOR 1.38; 95% CI 1.01-1.89, p = 0.041) was associated with severe CAC. Compared to the reference group, the overlapping group showed an association with CAC (aOR 1.22; 95% CI 1.01-1.47; p = 0.038); however, the MASLD and MAFLD subgroups did not differ in their association with CAC. MASLD may predict a higher risk of ASCVD more effectively than MAFLD. | Kang, Min Kyu; Song, Jeong Eun; Loomba, Rohit; Park, Soo Young; Tak, Won Young; Kweon, Young Oh; Lee, Yu Rim; Park, Jung Gil | Yeungnam Univ, Coll Med, Dept Internal Med, Daegu, South Korea; Univ Calif San Diego, MASLD Res Ctr, Dept Med, Div Gastroenterol & Hepatol, San Diego, CA USA; Daegu Catholic Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea | Kang, Min/U-8050-2018; Loomba, Rohit/AAE-7831-2019 | 59142854300; 57189097150; 12751805200; 57191674344; 7004074582; 7004694832; 57194094753; 57216816399 | deblue00@naver.com;gsnrs@naver.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 1.63 | 2025-05-07 | 6 | 5 | Metabolic dysfunction-associated steatotic liver disease; Metabolic dysfunction-associated fatty liver disease; Coronary artery calcification; Cardiovascular disease | FATTY LIVER-DISEASE; DELPHI CONSENSUS STATEMENT; ALL-CAUSE; RISK; ULTRASOUND; STEATOSIS; FIBROSIS | Cardiovascular disease; Coronary artery calcification; Metabolic dysfunction-associated fatty liver disease; Metabolic dysfunction-associated steatotic liver disease | Aged; Coronary Artery Disease; Coronary Vessels; Fatty Liver; Female; Humans; Male; Middle Aged; Prevalence; Risk Factors; Severity of Illness Index; Tomography, X-Ray Computed; Vascular Calcification; aged; blood vessel calcification; comparative study; complication; coronary artery disease; coronary blood vessel; diagnostic imaging; epidemiology; fatty liver; female; human; male; middle aged; pathology; prevalence; risk factor; severity of illness index; x-ray computed tomography | English | 2024 | 2024-10-02 | 10.1038/s41598-024-74287-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Comparing deep learning and handcrafted radiomics to predict chemoradiotherapy response for locally advanced cervical cancer using pretreatment MRI | Concurrent chemoradiotherapy (CRT) is the standard treatment for locally advanced cervical cancer (LACC), but its responsiveness varies among patients. A reliable tool for predicting CRT responses is necessary for personalized cancer treatment. In this study, we constructed prediction models using handcrafted radiomics (HCR) and deep learning radiomics (DLR) based on pretreatment MRI data to predict CRT response in LACC. Furthermore, we investigated the potential improvement in prediction performance by incorporating clinical factors. A total of 252 LACC patients undergoing curative chemoradiotherapy are included. The patients are randomly divided into two independent groups for the training (167 patients) and test datasets (85 patients). Contrast-enhanced T1- and T2-weighted MR scans are obtained. For HCR analysis, 1890 imaging features are extracted and a support vector machine classifier with a five-fold cross-validation is trained on training dataset to predict CRT response and subsequently validated on test dataset. For DLR analysis, a 3-dimensional convolutional neural network was trained on training dataset and validated on test dataset. In conclusion, both HCR and DLR models could predict CRT responses in patients with LACC. The integration of clinical factors into radiomics prediction models tended to improve performance in HCR analysis. Our findings may contribute to the development of personalized treatment strategies for LACC patients. | Jeong, Sungmoon; Yu, Hosang; Park, Shin-Hyung; Woo, Dongwon; Lee, Seoung-Jun; Chong, Gun Oh; Han, Hyung Soo; Kim, Jae-Chul | Kyungpook Natl Univ, Sch Med, Dept Med Informat, Daegu, South Korea; Kyungpook Natl Univ Hosp, Res Ctr Artificial Intelligence Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiat Oncol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Radiat Oncol, Daegu, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Gynecol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Clin Omics Res Ctr, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Physiol, Daegu, South Korea | Park, Shinhyung/LNQ-6428-2024 | 23100090400; 57205199961; 57203275843; 58738349500; 57204661287; 23099068000; 7401969388; 55719981700 | shinhyungpark@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 2.86 | 2025-05-07 | 9 | 9 | HUMAN-PAPILLOMAVIRUS; SURVIVAL | Chemoradiotherapy; Deep Learning; Female; Humans; Magnetic Resonance Imaging; Radiomics; Retrospective Studies; Uterine Cervical Neoplasms; chemoradiotherapy; controlled study; deep learning; diagnostic imaging; female; human; nuclear magnetic resonance imaging; procedures; radiomics; randomized controlled trial; retrospective study; uterine cervix tumor | English | 2024 | 2024-01-12 | 10.1038/s41598-024-51742-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Continuity of primary care and avoidable hospitalization in a young population with asthma: a population-based cohort study | Existing evidence regarding the impact of continuity of care (COC) in asthma patients is limited, and its quality is low to moderate. This study aimed to investigate associations between relational COC within primary care and asthma-related hospitalizations in children using a robust methodology. This study is a population-based cohort study that utilized a national claims database in South Korea. The study comprised 136,296 individuals under 20 years old who were newly diagnosed with asthma between 2015 and 2016. These were classified into high, medium, and low continuity groups based on the continuity of care index (COCI). The primary outcome measure was the incidence of asthma-related hospitalizations. During a two-year follow-up period, 10,922 patients (8.01%) were hospitalized: 2520 (5.59%) in the high-continuity group, 3188 (6.98%) in the medium-continuity group, and 3867 (8.48%) in the low-continuity group. After adjusting for confounding covariates, patients in the low- and medium-continuity groups exhibited significantly higher risks of hospital admission (adjusted hazard ratio (aHR) = 1.30 [95% confidence interval = 1.24-1.37] and aHR = 1.14 [1.08-1.20], than those in the high-continuity group. Sensitivity and subgroup analyses findings were consistent. In a young population with asthma increased continuity of primary care was associated with less hospitalization. | Lee, Iyn-Hyang; Kim, Sangwan; Choo, Eunjung; Jang, Eun Jin; Je, Nam Kyung | Yeungnam Univ, Coll Pharm, 280 Daehak Ro, Gyongsan 38541, Gyeongbuk, South Korea; Univ York, Dept Hlth Sci, York, England; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Seoul Natl Univ, Med Res Ctr, Inst Hlth Policy & Management, Seoul, South Korea; Ajou Univ, Coll Pharm, Suwon, South Korea; Andong Natl Univ, Dept Data Sci, Andong, South Korea; Pusan Natl Univ, Coll Pharm, Busandaehakro 63 Bungil 2, Busan 46241, South Korea | 54780158300; 59320974600; 57218497400; 37861741600; 56431162500 | leeiynhyang@ynu.ac.kr;jenk@pusan.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0 | 2025-05-07 | 0 | 0 | Asthma; Continuity of care; Relational continuity; Primary care; Hospitalization | ASSOCIATION; COSTS | Asthma; Continuity of care; Hospitalization; Primary care; Relational continuity | Adolescent; Asthma; Child; Child, Preschool; Cohort Studies; Continuity of Patient Care; Female; Hospitalization; Humans; Infant; Infant, Newborn; Male; Primary Health Care; Republic of Korea; Young Adult; adolescent; asthma; child; cohort analysis; epidemiology; female; hospitalization; human; infant; male; newborn; patient care; preschool child; primary health care; South Korea; therapy; young adult | English | 2024 | 2024-11-18 | 10.1038/s41598-024-78057-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Erratum | Correction to: Importance of dialysis specialists in early mortality in elderly hemodialysis patients: a multicenter retrospective cohort study (Scientific Reports, (2024), 14, 1, (1927), 10.1038/s41598-024-52170-9) | Correction to: Scientific Reportshttps://doi.org/10.1038/s41598-024-52170-9, published online 22 January 2024 The Funding section in the original version of this Article was incomplete. "This study was supported by the Konyang University Myunggok Research Fund (2021-02) and the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. RS-2022-00166592). This manuscript is a researcher-led paper with no specific participation by funders.” now reads: "This study was supported by the Konyang University Myunggok Research Fund (2021-02), the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. RS-2022-00166592), and the Cooperative Research Grant 2019 from the Korean Society of Nephrology. This manuscript is a researcher-led paper with no specific participation by funders.” The original Article has been corrected. © The Author(s) 2024. | Park, Yohan; Lee, Ji Won; Yoon, Se-Hee; Yun, Sung-Ro; Kim, Hyunsuk; Bae, Eunjin; Hyun, Young Youl; Chung, Sungjin; Kwon, Soon Hyo; Cho, Jang-Hee; Yoo, Kyung Don; Park, Woo Yeong; Sun, In O; Yu, Byung Chul; Ko, Gang-Jee; Yang, Jae Won; Song, Sang Heon; Shin, Sung Joon; Hong, Yu Ah; Hwang, Won Min | Division of Nephrology, Department of Internal Medicine, Konyang University Hospital, Daejeon, South Korea, Konyang University Myunggok Medical Research Institute, Daejeon, South Korea; Division of Nephrology, Department of Internal Medicine, Konyang University Hospital, Daejeon, South Korea; Division of Nephrology, Department of Internal Medicine, Konyang University Hospital, Daejeon, South Korea; Division of Nephrology, Department of Internal Medicine, Konyang University Hospital, Daejeon, South Korea; Division of Nephrology, Department of Internal Medicine, Hallym University Medical Center, Chuncheon Sacred Heart Hospital, Chuncheon, South Korea; Division of Nephrology, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, South Korea; Division of Nephrology, Department of Internal Medicine, Kangbuk Samsung Hospital, Seoul, South Korea; Division of Nephrology, Department of Internal Medicine, Yeouido St. Mary’s Hospital, Seoul, South Korea; Division of Nephrology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, South Korea; Division of Nephrology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, South Korea; Division of Nephrology, Department of Internal Medicine, Ulsan University Hospital, Ulsan, South Korea; Division of Nephrology, Department of Internal Medicine, Keimyung University Dongsan Hospital, Daegu, South Korea; Division of Nephrology, Department of Internal Medicine, Presbyterian Medical Center, Jeonju, South Korea; Division of Nephrology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea; Division of Nephrology, Department of Internal Medicine, Korea University Guro Hospital, Seoul, South Korea; Division of Nephrology, Department of Internal Medicine, Yonsei University Wonju Severance Christian Hospital, Wonju, South Korea; Division of Nephrology, Department of Internal Medicine, Pusan National University Hospital, Busan, South Korea; Division of Nephrology, Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, South Korea; Division of Nephrology, Department of Internal Medicine, Daejeon St. Mary’s Hospital, Daejeon, South Korea; Division of Nephrology, Department of Internal Medicine, Konyang University Hospital, Daejeon, South Korea | 57216616078; 58827113400; 55285801300; 36097271300; 57194217507; 55880508000; 57037163300; 23388171000; 57204097241; 7403536291; 56603636300; 36344980100; 36994821600; 57203908496; 8310760600; 59285795300; 36162581500; 55662651000; 55125210000; 55568773500 | hwangwm@kyuh.ac.kr; | Scientific Reports | SCI REP-UK | 2045-2322 | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0 | 2025-05-07 | 0 | aged; article; cohort analysis; dialysis; drug therapy; government; hemodialysis patient; human; Korea; medical specialist; mortality; nephrology; participation; retrospective study; diagnosis; drug withdrawal; erratum; multicenter study | English | Final | 2024 | 10.1038/s41598-024-55894-w | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Deciphering the ABA and GA biosynthesis approach of Bacillus pumilus, mechanistic approach, explaining the role of metabolic region as an aid in improving the stress tolerance | Bacillus pumilus plays an essential role in agricultural applications as a beneficial microbe and for sustainable agriculture production. However, the underlying mechanisms of B. pumilus strains remain unclear as to how they are beneficial for plants as stress tolerant and growth promoters. Bacillus pumilus was isolated from the rhizosphere soil of Artemisia vulgaris. NGS (next-generation sequencing) was performed for the strain to gain new insights into the molecular mechanisms underlying plant-microbial interactions. NGS revealed 3,910 genes, 3294 genes with protein-coding, and 11 functional genomic regions related to diverse agronomic traits including stress tolerance. We identified the two possible phytohormone biosynthesis approaches from metabolic regions1(terpense -> diterpense -> betacarotene -> xanthoxin -> ABA)2(terpense -> diterpense -> geranyl diphosphate -> C20 -> GA). Several gene clusters related to the biosynthesis of phytohormones, stress tolerance, and agricultural diversification were predicted. The genome provides insights into the possible mechanisms of this bacterium for stress tolerance and its future applications. The genomic organization of B. pumilus revealed several hallmarks of its plant growth promotion and pathogen suppression activities. Our results provide detailed genomic information for the strain and reveal its potential stress tolerance mechanisms, laying the foundation for developing effective stress tolerance strategies against abiotic stress. | Shaffique, Shifa; Shah, Anis Ali; Odongkara, Peter; Elansary, Hosam O.; Khan, Abdul Latif; Adhikari, Arjun; Kang, Sang-Mo; Lee, In-Jung | Kyungpook Natl Univ, Sch Appl Biosci, Daegu, South Korea; Univ Educ, Dept Bot, Div Sci & Technol, Lahore, Pakistan; King Saud Univ, Prince Sultan Bin Abdulaziz Int Prize Water Chair, Prince Sultan Inst Environm Water & Desert Res, Riyadh 11451, Saudi Arabia; Univ Houston, Dept Biol & Biochem, Houston, TX USA; Univ Houston, Dept Engn Technol, Sugar Land, TX USA | Kang, Sang-Mo/MBG-7823-2025; Adhikari, Arjun/JCO-3306-2023; Elansary, Hosam/E-3684-2019; Lee, In-Jung/GLS-0432-2022; Khan, Sher/H-2958-2012; shaffique, shifa/KUC-7102-2024; Shah, Dr. Anis/AAV-2232-2020 | 57203898867; 57211606140; 58514830500; 35388049900; 26639372800; 57195601415; 56189696900; 16425830900 | ijlee@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0.82 | 2025-05-07 | 2 | 2 | Bacillus pumilus; NGS; Food security; Secondary metabolites | OXIDATIVE STRESS; PLANT; MANAGEMENT; RESPONSES; HORMONES; GROWTH | Bacillus pumilus; Food security; NGS; Secondary metabolites | Abscisic Acid; Bacillus pumilus; Genome, Bacterial; High-Throughput Nucleotide Sequencing; Multigene Family; Plant Growth Regulators; Rhizosphere; Soil Microbiology; Stress, Physiological; abscisic acid; phytohormone; Bacillus pumilus; bacterial genome; biosynthesis; genetics; high throughput sequencing; metabolism; microbiology; multigene family; physiological stress; rhizosphere | English | 2024 | 2024-11-22 | 10.1038/s41598-024-78227-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Deep learning-based, fully automated, pediatric brain segmentation | The purpose of this study was to demonstrate the performance of a fully automated, deep learning-based brain segmentation (DLS) method in healthy controls and in patients with neurodevelopmental disorders, SCN1A mutation, under eleven. The whole, cortical, and subcortical volumes of previously enrolled 21 participants, under 11 years of age, with a SCN1A mutation, and 42 healthy controls, were obtained using a DLS method, and compared to volumes measured by Freesurfer with manual correction. Additionally, the volumes which were calculated with the DLS method between the patients and the control group. The volumes of total brain gray and white matter using DLS method were consistent with that volume which were measured by Freesurfer with manual correction in healthy controls. Among 68 cortical parcellated volume analysis, the volumes of only 7 areas measured by DLS methods were significantly different from that measured by Freesurfer with manual correction, and the differences decreased with increasing age in the subgroup analysis. The subcortical volume measured by the DLS method was relatively smaller than that of the Freesurfer volume analysis. Further, the DLS method could perfectly detect the reduced volume identified by the Freesurfer software and manual correction in patients with SCN1A mutations, compared with healthy controls. In a pediatric population, this new, fully automated DLS method is compatible with the classic, volumetric analysis with Freesurfer software and manual correction, and it can also well detect brain morphological changes in children with a neurodevelopmental disorder. | Kim, Min-Jee; Hong, Eunpyeong; Yum, Mi-Sun; Lee, Yun-Jeong; Kim, Jinyoung; Ko, Tae-Sung | Ulsan Univ, Coll Med, Dept Pediat, Asan Med Ctr,Childrens Hosp, 88 Olymp Ro 43-Gil, Seoul 05505, South Korea; Vuno Inc, Seoul 06541, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Pediat, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea | 57203241386; 57887680400; 21735652500; 55978748900; 56903729400; 7201681358 | misun.yum@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 1.23 | 2025-05-07 | 4 | 3 | Dravet syndrome; Deep learning-based segmentation; Convolutional neural network; VUNO Med-DeepBrain | SURFACE-BASED ANALYSIS; MRI SEGMENTATION; IMAGES; CHILDREN | Convolutional neural network; Deep learning-based segmentation; Dravet syndrome; VUNO Med-DeepBrain | Brain; Child; Deep Learning; Hippocampus; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Software; brain; child; deep learning; diagnostic imaging; hippocampus; human; image processing; nuclear magnetic resonance imaging; procedures; software | English | 2024 | 2024-02-22 | 10.1038/s41598-024-54663-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Development of deoxidation process for off-grade titanium sponge using magnesium metal with wire mesh strainer type of crucible | In this study, the deoxidation process for off-grade titanium (Ti) sponge using magnesium (Mg) metal with a wire mesh strainer type of crucible was developed. Ti hydride (TiH2) feedstock, which was prepared by hydrogenating off-grade Ti sponge, was deoxidized using Mg in a molten magnesium chloride-potassium chloride salt at 933 K under an argon and 20% hydrogen (H2) mixed gas atmosphere. After deoxidation, the residual Mg-containing salt was separated in situ from the crucible to investigate the feasibility of minimizing salt loss during the leaching and production of pure TiH2. The results showed that the presence of residual Mg-containing salt inside the crucible strongly influenced whether a mixture of Ti and TiH2 or pure TiH2 was produced. When the salt was not sufficiently separated, a mixture of Ti and TiH2 was obtained and its oxygen (O) concentration was 0.121 mass% under certain conditions. Meanwhile, pure TiH2 was obtained by increasing the H2 gas flow rate during deoxidation. Therefore, these results demonstrate that the decrease of O concentration to below 0.180 mass% and the minimal loss of the salt are feasible. | Park, Sung-Hun; Jeoung, Hyeong-Jun; Lee, Tae-Hyuk; Sohn, Ho-Sang; Kang, Jungshin | Seoul Natl Univ, Res Inst Energy & Resources, 1 Gwanak Ro, Seoul 08826, South Korea; Seoul Natl Univ, Dept Mat Sci & Engn, 1 Gwanak Ro, Seoul 08826, South Korea; Korea Inst Geosci & Mineral Resources, Resources Utilizat Res Div, 124 Gwahak Ro, Daejeon 34132, South Korea; Kyungpook Natl Univ, Sch Mat Sci & Engn, 80 Daehak Ro, Daegu 41566, South Korea; Seoul Natl Univ, Dept Energy Resources Engn, 1 Gwanak Ro, Seoul 08826, South Korea | Park, Sung-Hun/JZS-8726-2024 | 57208205988; 57218880377; 37122229800; 7201426373; 55637737500 | kangjs@snu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 1.63 | 2025-05-07 | 5 | 4 | LOW-OXYGEN; ELECTROCHEMICAL DEOXIDATION; THERMODYNAMIC PROPERTIES; SOLID-SOLUTION; POWDER; ALLOY; REDUCTION; DEOXYGENATION; REMOVAL; MG | argon; hydrogen; magnesium; magnesium chloride; metal; oxygen; potassium chloride; sodium chloride; titanium; article; controlled study; flow rate; gas flow; leaching; sodium depletion | English | 2024 | 2024-01-04 | 10.1038/s41598-023-50765-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Article | Different diabetogenic effect of statins according to intensity and dose in patients with acute myocardial infarction: a nationwide cohort study | Statin is crucial for acute myocardial infarction (AMI) patients. However, the risk of new-onset diabetes mellitus (NODM) associated with statin is a concern. This study aimed to determine the incremental diabetogenic effects of statins according to their intensity and dose in AMI patients undergoing percutaneous coronary intervention (PCI). Among 13,104 patients enrolled in the Korea AMI Registry between 2011 and 2015, 6152 patients without diabetes mellitus (DM) who underwent PCI and received moderate-to-high-intensity atorvastatin and rosuvastatin were selected for the study. The endpoints were NODM and major adverse cardiovascular events (MACE), composite of all-cause mortality, recurrent MI, and revascularization up to 3 years. Among the participants, 3747 and 2405 received moderate- and high-intensity statins, respectively. The Kaplan–Meier curves demonstrated a higher incidence of NODM in patients with high-intensity statins than those with moderate-intensity. High-intensity statin was a significant predictor of NODM after adjusting for other co-variables (HR = 1.316, 95% CI 1.024–1.692; P < 0.032). Higher dose of rosuvastatin was associated with a higher cumulative incidence of NODM, but this dose-dependency was not apparent with atorvastatin. Cumulative incidence of MACE decreased dose-dependently only with atorvastatin. High-intensity statin was associated with a higher cumulative incidence of NODM in AMI patients, and this association was more evident in rosuvastatin. The different diabetogenic effects of the two statins provide supporting evidence for understanding the nuanced nature of statin treatment in relation to NODM. © The Author(s) 2024. | Lee, Jieun; Choi, Jah Yeon; Choi, Byoung Geol; Choi, You-Jung; Park, Soohyung; Kang, Dong Oh; Park, Eun Jin; Kim, Ji Bak; Roh, Seung Young; Na, Jin Oh; Choi, Cheol Ung; Kim, Eung Ju; Park, Chang Gyu; Jeong, Myung Ho; Hwang, Jin-Yong; Hur, Seung-Ho; Jeong, Jin-Ok; Oh, SeokKyu; Rha, Seung-Woon; Rha, Seung-Woon; Ahn, Tae Hoon; Yoon, Junghan; Kim, Hyo-Soo; Seung, Ki-Bae; Gwon, Hyeon-Cheol; Chae, Shung Chull; Kim, Chong-Jin; Cha, Kwang Soo; Lee, Jung-Hee; Chae, Jei Keon; Joo, Seung-Jae; Yoon, Chang-Hwan; Seong, In-Whan; Hwang, Kyung-Kuk; Kim, Doo-Il | Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, 148, Gurodong-Ro, Guro-Gu, Seoul, 08308, South Korea; Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, 148, Gurodong-Ro, Guro-Gu, Seoul, 08308, South Korea; Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, 148, Gurodong-Ro, Guro-Gu, Seoul, 08308, South Korea; Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, 148, Gurodong-Ro, Guro-Gu, Seoul, 08308, South Korea; Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, 148, Gurodong-Ro, Guro-Gu, Seoul, 08308, South Korea; Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, 148, Gurodong-Ro, Guro-Gu, Seoul, 08308, South Korea; Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, 148, Gurodong-Ro, Guro-Gu, Seoul, 08308, South Korea; Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, 148, Gurodong-Ro, Guro-Gu, Seoul, 08308, South Korea; Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, 148, Gurodong-Ro, Guro-Gu, Seoul, 08308, South Korea; Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, 148, Gurodong-Ro, Guro-Gu, Seoul, 08308, South Korea; Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, 148, Gurodong-Ro, Guro-Gu, Seoul, 08308, South Korea; Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, 148, Gurodong-Ro, Guro-Gu, Seoul, 08308, South Korea; Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, 148, Gurodong-Ro, Guro-Gu, Seoul, 08308, South Korea; Chonnam National University Hospital, Gwangju, South Korea; Department of Internal Medicine, Gyeongsang National University School of Medicine, Gyeongsang National University Hospital, Jinju, South Korea; Keimyung University Dongsan Medical Center, Cardiovascular Medicine, Deagu, South Korea; Department of Internal Medicine, College of Medicine, Chungnam National University Hospital, Chungnam National Univeresity, Daejeon, South Korea; Division of Cardiology, Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, South Korea; Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, 148, Gurodong-Ro, Guro-Gu, Seoul, 08308, South Korea; Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, 148, Gurodong-Ro, Guro-Gu, Seoul, 08308, South Korea; Gachon University Gil Medical Center, Incheon, South Korea; Wonju Severance Christian Hospital, Wonju, South Korea; Seoul National University Hospital, Seoul, South Korea; Seoul St. Mary’s Hospital, Seoul, South Korea; Samsung Medical Center, Seoul, South Korea; Kyungpook National University Hospital, Daegu, South Korea; Kyunghee University Hospital At Gangdong, Seoul, South Korea; Pusan National University Hospital, Busan, South Korea; Yeungnam University Medical Center, Daegu, South Korea; Chonbuk National University Hospital, Jeongju, South Korea; Jeju National University Hospital, Jeju, South Korea; Seoul National University Bundang Hospital, Bundang, South Korea; Department of Internal Medicine, College of Medicine, Chungnam National University Hospital, Chungnam National Univeresity, Daejeon, South Korea; Chungbuk National University Hospital, Cheongju, South Korea; Inje University Haeundae Paik Hospital, Busan, South Korea | 57222092116; 56706628900; 59032367500; 57203086905; 57719909900; 57209310106; 57200596461; 35783188500; 35783384000; 23987318500; 15046409800; 7404507139; 33767951400; 56485157500; 55892914700; 34570274500; 57210973601; 24734336000; 8569030400; 59968334300; 57222278496; 35760728900; 33567809200; 7003964208; 6603262426; 7101962036; 35229511500; 7102837700; 55969086000; 26029709000; 9236504200; 7202882965; 35254371300; 58842870300; 8635545900 | swrha617@yahoo.co.kr; | Scientific Reports | SCI REP-UK | 2045-2322 | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0.41 | 2025-05-07 | 1 | Acute myocardial infarction; New-onset diabetes mellitus; Statin intensity | Aged; Atorvastatin; Cohort Studies; Diabetes Mellitus; Dose-Response Relationship, Drug; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Registries; Republic of Korea; Rosuvastatin Calcium; atorvastatin; hydroxymethylglutaryl coenzyme A reductase inhibitor; rosuvastatin; adverse event; aged; cohort analysis; diabetes mellitus; dose response; drug therapy; epidemiology; female; heart infarction; human; incidence; male; middle aged; percutaneous coronary intervention; register; South Korea | English | Final | 2024 | 10.1038/s41598-024-67585-7 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Differential gene expression in the kidneys of SHR and WKY rats after intravenous administration of Akkermansia muciniphila-derived extracellular vesicles | Although Akkermansia muciniphila (Am) plays a beneficial role as a probiotic in the treatment of metabolic syndrome, the mechanisms remain elusive. We tested the hypothesis that Am extracellular vesicles (AmEVs) protect against hypertension through modulation of gene expression in the kidneys of spontaneously hypertensive rats (SHRs). Extracellular vesicles purified from anaerobically cultured Am (1.0 x 10(8) or 1.0 x 10(9) particles/kg) or vehicles were injected into the tail veins of Wistar-Kyoto rats (WKYs) and SHRs weekly for 4 weeks. Renal cortical tissues isolated from both rat strains were analyzed by trichrome stain and RT-qPCR. AmEVs protect against the development of hypertension in SHRs without a serious adverse reaction. AmEVs increased the expression of vasocontracting Agt and At1ar as well as vasodilating At2r, Mas1 and Nos2 in the kidneys of both strains. These results indicate that AmEVs have a protective effect against hypertension without a serious adverse reaction. Therefore, it is foreseen that AmEVs may be utilized as a novel therapeutic for the treatment of hypertension. | Olarinoye, Zainab Yetunde; Kim, Cheong-Wun; Kim, Jee Young; Jang, Sungmin; Kim, Inkyeom | Kyungpook Natl Univ, Sch Med, Dept Pharmacol, 680 Gukchaebosang St, Daegu 41944, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Daegu 41944, South Korea; Kyungpook Natl Univ, BK21 Plus KNU Biomed Convergence Program, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, Daegu 41944, South Korea | 58925215900; 56662531400; 57222261625; 57897824500; 7404144630 | inkim@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0.41 | 2025-05-07 | 1 | 1 | Akkermansia muciniphila; Hypertension; Extracellular vesicles; Differential Gene Expression; Spontaneous hypertensive rats | RENIN-ANGIOTENSIN SYSTEM; CONVERTING ENZYME; IMMUNE-SYSTEM; HYPERTENSION; CAPTOPRIL | Akkermansia muciniphila; Differential Gene Expression; Extracellular vesicles; Hypertension; Spontaneous hypertensive rats | Administration, Intravenous; Akkermansia; Akkermansia muciniphila; Animals; Extracellular Vesicles; Gene Expression Regulation; Hypertension; Kidney; Male; Probiotics; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Verrucomicrobia; probiotic agent; Akkermansia; Akkermansia muciniphila; animal; exosome; gene expression regulation; genetics; hypertension; intravenous drug administration; kidney; male; metabolism; rat; spontaneously hypertensive rat; Verrucomicrobia; Wistar Kyoto rat | English | 2024 | 2024-08-29 | 10.1038/s41598-024-69757-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Direct oral anticoagulants for oral anticoagulants-naïve Asian patients with atrial fibrillation and end-stage renal disease undergoing dialysis | In Asian patients with atrial fibrillation (AF) and end-stage renal disease (ESRD) undergoing dialysis, the use of direct oral anticoagulants (DOACs) remains debatable. From the national health insurance claims data in South Korea, we included 425 new users of OAC among patients with non-valvular AF and ESRD undergoing dialysis between 2013 and 2020. Patients were categorized into DOAC (n = 106) and warfarin group (n = 319). Clinical outcomes, including ischemic stroke, myocardial infarction (MI), intracranial hemorrhage (ICH), and gastrointestinal (GI) bleeding, were compared between the two groups using inverse probability of treatment weighting (IPTW) analysis. During the median follow-up of 3.2 years, the incidence of ischemic stroke was significantly reduced in the DOAC compared to the warfarin group [Hazard ratio (HR) 0.07; P = 0.001]. However, the incidence of MI (HR 1.32; P = 0.41) and GI bleeding (HR 1.78; P = 0.06) were not significantly different between the two groups. No ICH events occurred in the DOAC group, although the incidence rate did not differ significantly between the two groups (P = 0.17). In Asian patients with AF and ESRD undergoing dialysis, DOACs may be associated with a reduced risk of ischemic stroke compared with warfarin. The MI, ICH, and GI bleeding rates may be comparable between DOACs and warfarin. | Roh, Jae-Hyung; Kim, Yong-Giun; Kim, Doyeon; Park, Sangwoo; Park, Kyung Sun; Kim, Minsu; Hwang, Ki Won; Hwang, Wonmook; Park, Gyung-Min; Lee, Jae-Hwan | Chungnam Natl Univ, Sejong Hosp, Sch Med, Div Cardiol, Sejong, South Korea; Univ Ulsan, Ulsan Univ Hosp, Coll Med, Dept Cardiol, Ulsan, South Korea; Kyungpook Natl Univ, Grad Sch Data Sci, Daegu, South Korea; Univ Ulsan, Ulsan Univ Hosp, Coll Med, Dept Nephrol, Ulsan, South Korea; Pusan Natl Univ, Pusan Natl Univ Med, Yangsan Hosp, Div Cardiol, Yangsan, South Korea | ; Park, M.J./Y-5611-2019; Park, Sangwoo/ADD-6552-2022 | 57216309871; 57207444006; 57813354300; 57197715007; 57188649178; 59073010000; 36122965400; 57218441906; 25924423800; 36066387900 | apollo0822@naver.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0 | 2025-05-07 | 0 | 0 | INTRACRANIAL HEMORRHAGE; WARFARIN USE; HEMODIALYSIS; STROKE; APIXABAN; RISK; METAANALYSIS; RIVAROXABAN; EFFICACY; SAFETY | Administration, Oral; Aged; Aged, 80 and over; Anticoagulants; Asian People; Atrial Fibrillation; Female; Gastrointestinal Hemorrhage; Humans; Incidence; Ischemic Stroke; Kidney Failure, Chronic; Male; Middle Aged; Myocardial Infarction; Renal Dialysis; Republic of Korea; Warfarin; anticoagulant agent; warfarin; adverse event; aged; Asian; atrial fibrillation; chronic kidney failure; complication; drug therapy; epidemiology; etiology; female; gastrointestinal hemorrhage; heart infarction; hemodialysis; human; incidence; ischemic stroke; male; middle aged; oral drug administration; prevention and control; South Korea; therapy; very elderly | English | 2024 | 2024-06-25 | 10.1038/s41598-024-65541-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Disease progression associated cytokines in COVID-19 patients with deteriorating and recovering health conditions | Understanding the immune response to COVID-19 is challenging due to its high variability among individuals. To identify differentially expressed cytokines between the deteriorating and recovering phases, we analyzed the Electronic Health Records (EHR) and cytokine profile data in a COVID-19 cohort of 444 infected patients and 145 non-infected healthy individuals. We categorized each patient's progression into Deterioration Phase (DP) and Recovery Phase (RP) using longitudinal neutrophil, lymphocyte and lactate dehydrogenase levels. A random forest model was built using healthy and severe patients to compute the contribution of each cytokine toward disease progression using Shapley Additive Explanations (SHAP). SHAP values were used for supervised clustering to identify DP and RP-related samples and their associated cytokines. The identified clusters effectively discriminated DP and RP samples, suggesting that the cytokine profiles differed between deteriorating and recovering health conditions. Especially, CXCL10, GDF15, PTX3, and TNFSF10 were differentially expressed between the DP and RP samples, which are involved in the JAK-STAT, NF-kappa\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\kappa$$\end{document}B, and MAPK signaling pathways contributing to the inflammatory response. Collectively, we characterized the immune response in terms of disease progression of COVID-19 with deteriorating and recovering health conditions. | Han, Eonyong; Youn, Sohyun; Kwon, Ki Tae; Kim, Sang Cheol; Jo, Hye-Yeong; Jung, Inuk | Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Chilgok Hosp, 807 Hoguk Ro, Daegu 41404, South Korea; Korea Dis Control & Prevent Agcy, Korea Natl Inst Hlth, Dept Precis Med, Div Healthcare & Artificial Intelligence, Cheongju 28159, South Korea | Kim, So-Young/JFS-7698-2023; Kim, Sungjae/AAB-4750-2022 | 58144883400; 59347828200; 9733850500; 55989489800; 57158666600; 56067575500 | jhy1227@korea.kr;inukjung@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0 | 2025-05-07 | 2 | 2 | Cytokine; Disease progression; Longitudinal; Severity; COVID-19 | SENSITIVE K+ CHANNELS; INSULIN-SECRETION; MICROFLUIDIC DEVICE; PANCREATIC-ISLETS; CYTOPLASMIC CA2+; SINGLE-MOUSE; GLUCOSE; CELLS; OSCILLATIONS; STIMULATION | COVID-19; Cytokine; Disease progression; Longitudinal; Severity | Adult; Aged; COVID-19; Cytokines; Disease Progression; Female; Humans; Male; Middle Aged; SARS-CoV-2; cytokine; adult; aged; coronavirus disease 2019; disease exacerbation; female; human; immunology; isolation and purification; male; metabolism; middle aged; pathology; Severe acute respiratory syndrome coronavirus 2; virology | English | 2024 | 2024-10-21 | 10.1038/s41598-024-75924-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial | Irritable bowel syndrome is a chronic disorder affecting the gastrointestinal tract, negatively impacting patients' quality of life. Here, we aimed to evaluate the effects of Lacticaseibacillus rhamnosus IDCC 3201 (RH 3201) on irritable bowel syndrome with constipation (IBS-C). In this randomised, double-blind, placebo-controlled trial, a total of 30 subjects with IBS-C were randomly assigned (1:1) to receive 8 weeks of probiotics administration or placebo. Concerning bowel activities, both irritant bowel movements and discomfort caused by constipation showed significant improvement with RH 3201 at 8 weeks. Symptoms including severity of abdominal bloating, frequency of abdominal bloating, and satisfaction of bowel habits based on the irritable bowel syndrome-severity scoring system also ameliorated in the probiotic group. Analysis of the fecal microbiome revealed that the abundance of Bacteroides cellulosilyticus and Akkermansia muciniphila was higher during the period of RH 3201 administration compared to the placebo. Untargeted metabolome analysis further suggested a correlation between specific metabolites, such as N-acetylornithine, xanthine, and 3-phenylpropionic acid, and the improvement of clinical symptoms. These results indicate that RH 3201 was effective in ameliorating IBS-C, potentially by enriching beneficial microbes and associated metabolites in the gut environment. | Kwon, Hyeji; Nam, Eoun Ho; Kim, Hayoung; Jo, Haneul; Bang, Won Yeong; Lee, Minjee; Shin, Hyeonmin; Kim, Dana; Kim, Jeongho; Kim, Hyejin; Lee, Jongkyun; Jung, Young Hoon; Yang, Jungwoo; Won, Daeyoun David; Shin, Minhye | Seoul Song Colorectal Hosp, Immunol Lab, Canc Genom Res Inst, Seoul 04597, South Korea; Inha Univ, Coll Med, Dept Microbiol, Incheon 22212, South Korea; Inha Univ, Dept Biomed Sci, Program Biomed Sci & Engn, Incheon 22212, South Korea; Ildong Biosci, Pyeongtaek Si 17957, Gyeonggi Do, South Korea; Seoul Song Do Colorectal Hosp, Digest Endoscop Ctr, Seoul 04597, South Korea; Seoul Song Do Colorectal Hosp, Pelv Floor Ctr, Dept Surg, Seoul 04597, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Fermentat Biotechnol, Daegu 41566, South Korea; Dongguk Univ, Dept Microbiol, Coll Med, 123 Dongdae Ro, Gyeongju 38066, South Korea | Jung, YoungHoon/LCE-3750-2024 | 59079919800; 58035371200; 57451681800; 59348110200; 57208701768; 57221979843; 57350858700; 59348121500; 59348121600; 59348134600; 56121052500; 55550063700; 56076383700; 36115835000; 57208401604 | dbl3jwy@dongguk.ac.kr;greatsongdo@gmail.com;mhshin@inha.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0.82 | 2025-05-07 | 3 | 4 | GUT MICROBIOTA; PROBIOTICS; QUESTIONNAIRE; VALIDATION; DIET | Adult; Constipation; Double-Blind Method; Feces; Female; Gastrointestinal Microbiome; Humans; Irritable Bowel Syndrome; Lacticaseibacillus rhamnosus; Male; Middle Aged; Probiotics; Treatment Outcome; probiotic agent; adult; complication; constipation; controlled study; double blind procedure; drug effect; drug therapy; feces; female; human; intestine flora; irritable colon; Lactobacillus rhamnosus; male; microbiology; middle aged; randomized controlled trial; therapy; treatment outcome | English | 2024 | 2024-09-27 | 10.1038/s41598-024-72887-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Effect of magnetic microbeads on sustained and targeted delivery of transforming growth factor-beta-1 for rotator cuff healing in a rat rotator cuff repair model | Structural failure is a well-established complication of rotator cuff repair procedures. To evaluate the effect of magnetic microbeads, designed for precise drug delivery via magnetic force, on sustained transforming growth factor-beta-1 (TGF-beta 1) release and rotator cuff healing in a rat rotator cuff repair model. TGF-beta 1 laden microbeads were prepared, and baseline in vitro experiments included the magnetization of the microbeads and TGF-beta 1 release tests. In an in vivo experiment using a rat rotator cuff repair model on both shoulders, 72 rats were randomly assigned to three groups (24 per group): group A, conventional repair; group B, repair with and simple TGF-beta 1 injection; and group C, repair with magnet insertion into the humeral head and TGF-beta 1 laden microbead injection. Delivery of TGF-beta 1 was evaluated at 1 and 7 days after the intervention using PCR, Western blot, and immunohistochemistry. At 6 weeks post-intervention, rotator cuff healing was assessed using biomechanical and histological analysis. The in vitro experiments confirmed the magnetization property of the microbeads and sustained delivery of TGF-beta 1 for up to 10 days. No difference in the TGF-beta 1 expression was found at day 1 in vivo. However, at day 7, group C exhibited a significantly elevated expression of TGF-beta 1 in both PCR and Western blot analyses compared to groups A and B (all P < 0.05). Immunohistochemical analysis revealed a higher expression of TGF-beta 1 at the repair site in group C on day 7. At 6 weeks, biomechanical analysis demonstrated a significantly higher ultimate failure load in group C than in groups A and B (P < 0.05) and greater stiffness than in group A (P = 0.045). In addition, histological analysis showed denser and more regular collagen fibers with complete continuity to the bone in group C than in groups A and B, a statistically significant difference according to the semi-quantitative scoring system (all P < 0.05). The use of the TGF-beta 1 laden magnetic microbeads demonstrated sustained delivery of TGF-beta 1 to the repair site, improving rotator cuff healing. | Lee, Jeongkun; Park, Jinwoo; Chang, Yeongjun; Yoon, Jong Pil; Chung, Seok Won | Konkuk Univ, Dept Orthopaed Surg, Sch Med, 120-1 Neungdong Ro Hwayang Dong, Seoul 143729, South Korea; Biot Korea Inc, 43-26 Chemdangwagi Ro 208 Beon Gil, Gwangju 61001, South Korea; Kyungpook Natl Univ, Sch Med, Dept Orthopaed Surg, Daegu, South Korea | 58496864100; 59240500700; 59240822600; 36098548400; 37065938600 | smilecsw@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 14 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 3.9 | 18.1 | 0.41 | 2025-05-07 | 2 | 2 | Magnetic microbead; TGF beta 1; Rotator cuff tear repair; Sustained drug delivery | TEAR; POPULATION; SHOULDER; BEAD | Magnetic microbead; Rotator cuff tear repair; Sustained drug delivery; TGF beta 1 | Animals; Disease Models, Animal; Drug Delivery Systems; Male; Microspheres; Rats; Rats, Sprague-Dawley; Rotator Cuff; Rotator Cuff Injuries; Transforming Growth Factor beta1; Wound Healing; microsphere; transforming growth factor beta1; animal; disease model; drug delivery system; drug effect; drug therapy; male; metabolism; pathology; rat; rotator cuff; rotator cuff injury; Sprague Dawley rat; surgery; wound healing | English | 2024 | 2024-07-31 | 10.1038/s41598-024-67572-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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