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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Network analysis of trauma in patients with early-stage psychosis | Childhood trauma (ChT) is a risk factor for psychosis. Negative lifestyle factors such as rumination, negative schemas, and poor diet and exercise are common in psychosis. The present study aimed to perform a network analysis of interactions between ChT and negative lifestyle in patients and controls. We used data of patients with early-stage psychosis (n = 500) and healthy controls (n = 202). Networks were constructed using 12 nodes from five scales: the Brief Core Schema Scale (BCSS), Brooding Scale (BS), Dietary Habits Questionnaire, Physical Activity Rating, and Early Trauma Inventory Self Report-Short Form (ETI). Graph metrics were calculated. The nodes with the highest predictability and expected influence in both patients and controls were cognitive and emotional components of the BS and emotional abuse of the ETI. The emotional abuse was a mediator in the shortest pathway connecting the ETI and negative lifestyle for both groups. The negative others and negative self of the BCSS mediated emotional abuse to other BCSS or BS for patients and controls, respectively. Our findings suggest that rumination and emotional abuse were central symptoms in both groups and that negative others and negative self played important mediating roles for patients and controls, respectively. Trial Registration: ClinicalTrials.gov identifier: CUH201411002. | Chung, Young-Chul; Yun, Je-Yeon; Thong Ba Nguyen; Rami, Fatima Zahra; Piao, Yan Hong; Li, Ling; Lee, Bomi; Kim, Woo-Sung; Sui, Jing; Kim, Sung-Wan; Lee, Bong Ju; Kim, Jung Jin; Yu, Je-Chun; Lee, Kyu Young; Won, Seung-Hee; Lee, Seung-Hwan; Kim, Seung-Hyun; Kang, Shi Hyun; Kim, Eui Tae | Jeonbuk Natl Univ, Dept Psychiat, Med Sch, 20 Geonji Ro, Jeonju 54907, South Korea; Jeonbuk Natl Univ, Res Inst Clin Med, Jeonbuk Natl Univ Hosp, Biomed Res Inst, Jeonju 54907, South Korea; Jeonbuk Natl Univ Hosp, Dept Psychiat, Jeonju 54907, South Korea; Seoul Natl Univ Hosp, Seoul 03080, South Korea; Seoul Natl Univ, Yeongeon Student Support Ctr, Coll Med, Seoul 03080, South Korea; Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China; Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China; Univ Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing 100049, Peoples R China; Chonnam Natl Univ, Dept Psychiat, Med Sch, Gwangju 61469, South Korea; Inje Univ, Haeundae Paik Hosp, Dept Psychiat, Coll Med, Busan 48108, South Korea; Catholic Univ Korea, Dept Psychiat, Seoul St Marys Hosp, Seoul 07345, South Korea; Eulji Univ, Eulji Univ Hosp, Dept Psychiat, Sch Med, Daejeon 35233, South Korea; Eulji Univ, Eulji Gen Hosp, Dept Psychiat, Sch Med, Seoul 01830, South Korea; Kyungpook Natl Univ, Dept Psychiat, Sch Med, Daegu 41944, South Korea; Inje Univ, Dept Psychiat, Coll Med, Goyang 10380, South Korea; Korea Univ, Guro Hosp, Dept Psychiat, Coll Med, Seoul 08308, South Korea; Natl Ctr Mental Hlth, Dept Psychosocial Rehabil, Seoul 04933, South Korea; Seoul Natl Univ, Dept Psychiat, Bundang Hosp, Seongnam 13620, South Korea | Lee, Yo Han/IUN-3410-2023; Rami, Fatima/ABS-5222-2022; Sui, Jing/B-3455-2018; Kim, Jungjin/MTF-3196-2025; Kim, Woo-Sung/L-9560-2017; Nguyen, Ba Thong/ADQ-2780-2022; Lee, Jungmin/KHT-2438-2024; Chung, Young/AAB-8242-2022 | 55712695800; 55271657400; 56956064000; 57231663300; 57205143111; 57232581000; 57352457900; 57205973432; 56579803600; 47962371200; 59053777300; 36079817200; 56022915400; 24376890800; 35278955600; 56739411100; 57196226681; 36523091800; 55756823600 | chungyc@jbnu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 0.49 | 2025-07-30 | 10 | 11 | CHILDHOOD TRAUMA; PSYCHOMETRIC PROPERTIES; DEPRESSIVE SYMPTOMS; NEGATIVE SYMPTOMS; SELF-ESTEEM; SCHIZOPHRENIA; RUMINATION; SUICIDALITY; EXPERIENCES; DISORDER | Adult; Cross-Sectional Studies; Female; Humans; Longitudinal Studies; Male; Middle Aged; Neural Networks, Computer; Psychiatric Status Rating Scales; Psychotic Disorders; Risk Factors; Self Report; Surveys and Questionnaires; Wounds and Injuries; Young Adult; adult; complication; cross-sectional study; female; human; injury; longitudinal study; male; middle aged; pathology; psychological rating scale; psychology; psychosis; questionnaire; risk factor; self report; young adult | English | 2021 | 2021-11-23 | 10.1038/s41598-021-01574-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Ni-Fe phosphide deposited carbon felt as free-standing bifunctional catalyst electrode for urea electrolysis | A free-standing catalyst electrode for the urea oxidation reaction (UOR) and hydrogen evolution reaction (HER) in a urea electrolysis cell was synthesized by electroplating a Ni-Fe alloy onto carbon felt, followed by phosphidation (P-NiFe@CF). The prepared P-NiFe@CF catalyst consisted of Ni5P4, NiP2, and FeP with 3D flower-like P-NiFe architecture on CF. P-NiFe@CF exhibited excellent electrocatalytic activity for the UOR (demanding only 1.39 V (vs. RHE) to achieve 200 mA cm(-2)), and for the HER with a low overpotential of 0.023 V (vs. RHE) at 10 mA cm(-2), indicating its feasibility as a bifunctional catalyst electrode for urea electrolysis. A urea electrolysis cell with P-NiFe@CF as both the free-standing anode and cathode generated a current density of 10 mA cm(-2) at a cell potential of 1.37 V (vs. RHE), which is considerably lower than that of water electrolysis, and also lower than previously reported values. The results indicate that the P-NiFe@CF catalyst electrodes can be used as free-standing bifunctional electrodes for urea electrolyzers. | Yun, Woo Hyun; Das, Gautam; Kim, Bohyeon; Park, Bang Ju; Yoon, Hyon Hee; Yoon, Young Soo | Gachon Univ, Dept Chem & Biol Engn, Seongnam 461701, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Dept Polymer Sci & Engn, Daegu, South Korea; Gachon Univ, Dept Elect Engn, Seongnam 461701, Gyeonggi Do, South Korea; Gachon Univ, Dept Mat Sci & Engn, Seongnam 461701, Gyeonggi Do, South Korea | Yoon, Hyon/AAW-7807-2020; Yoon, Young Soo/LYO-5503-2024 | 57213590320; 24358918500; 57207967054; 57191754554; 55663131500; 55647164856 | hhyoon@gachon.ac.kr;benedicto@gachon.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 1.14 | 2025-07-30 | 31 | 24 | TRANSITION-METAL PHOSPHIDE; OXYGEN EVOLUTION REACTION; LAYERED DOUBLE HYDROXIDE; HIGH-PERFORMANCE; HIGHLY EFFICIENT; HYDROGEN-PRODUCTION; ORGANIC FRAMEWORKS; NANOSHEET ARRAYS; NANOWIRE ARRAYS; DOPED CARBON | English | 2021 | 2021-11-09 | 10.1038/s41598-021-01383-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Opioid use may be associated with postoperative complications in myotonic dystrophy type 1 with high-grade muscular impairment | Individuals with myotonic dystrophy type 1 (DM1) reportedly have a higher risk of postoperative complications than those without DM1; however, factors related to perioperative complications in DM1 patients remain unclear. We aimed to identify the risk factors that may be associated with postoperative complications in DM1 patients. We reviewed medical records of 256 patients with DM1 from 1998 to 2018, among whom 42 (16.4%) had previously undergone 51 surgeries under general and regional anaesthesia. Among the 42 patients, 11 (21.5%) had 13 postoperative complications including respiratory complications, sustained hypotension, wound infection and dehiscence, artery thrombosis and occlusion, and delayed recovery from anaesthesia. There were significant inter-group differences between the non-complicated and complicated groups considering the following parameters: high-grade (>= 3) muscular impairment rating scale (MIRS), extubation time, postoperative opioid use, and hospital length of stay. Furthermore, univariate analysis revealed that an MIRS score >= 3 (odds ratio [OR] 9.346, confidence interval [CI] 1.761-49.595, p=0.009) and postoperative opioid use (OR 8.000, CI 1.772-36.127, p=0.007) were the only statistically significant factors. Therefore, clinicians should be cautious in administering opioids, particularly in patients with a high-grade MIRS score during the perioperative period. | Kim, Chan-Sik; Park, Jin-Mo; Park, Donghwi; Kim, Doo-Hwan; Park, Jin-Sung | Univ Ulsan, Asan Med Ctr, Coll Med, Dept Anesthesiol & Pain Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea; Dongguk Univ, Coll Med, Dept Neurol, Gyeongju, South Korea; Univ Ulsan, Ulsan Univ Hosp, Coll Med, Dept Phys Med & Rehabil, Ulsan, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, 807 Hoguk Ro, Daegu 41404, South Korea | Kim, Chan-Sik/KUC-8389-2024; Park, Donghwi/GYQ-6185-2022 | 57193329925; 55569003000; 56606561400; 56109791900; 44061744500 | knaaddict@gmail.com;jinforeva@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 0.38 | 2025-07-30 | 8 | 7 | Adolescent; Adult; Analgesics, Opioid; Anesthetics; Asian Continental Ancestry Group; Child; Child, Preschool; Female; Humans; Male; Myotonic Dystrophy; Pain, Postoperative; Postoperative Complications; Respiratory Insufficiency; Risk Factors; Severity of Illness Index; Young Adult; anesthetic agent; narcotic analgesic agent; adolescent; adult; Asian continental ancestry group; child; complication; female; human; male; myotonic dystrophy; pathophysiology; postoperative complication; postoperative pain; preschool child; respiratory failure; risk factor; severity of illness index; young adult | English | 2021 | 2021-01-11 | 10.1038/s41598-020-76217-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Osmotically balanced, large unilamellar liposomes that enable sustained bupivacaine release for prolonged pain relief in in vivo rat models | To efficiently prolong analgesic effects, we developed osmotically balanced, large unilamellar liposomes (similar to 6 mu m in diameter) in which highly concentrated bupivacaine (up to 30 mg/mL) was encapsulated, and their sustained bupivacaine release was highly effective in relieving postoperative pain over 24 h in a rat model. Our reverse-phase evaporation method based on non-toxic alcohol, ethanol, enabled simple and cost-effective production of bupivacaine-loaded liposomes, of which osmotic pressure was readily balanced to improve the structural stability of the enlarged unilamellar liposomes along with extension of their shelf life (>a month). The in vitro release profile verified that the release duration of the bupivacaine-loaded liposomes extended up to 6 days. For the in vivo study, male Sprague-Dawley rats were used for the incisional pain model, simulating postoperative pain, and the mechanical withdrawal threshold (MWT) was measured using a von Frey filament. Compared to the control group that received intraplantar administration of normal saline, the group of liposomal bupivacaine showed that the initially increased MWT gradually decreased up to 24 h, and importantly, the analgesic effect of the liposomal bupivacaine was maintained 6 times longer than that of bupivacaine only, proving the potential of effective long-acting anesthetics. | Yoo, Hyebin; Park, Jun Seok; Oh, Seung Soo; Kang, Hyun | Pohang Univ Sci & Technol POSTECH, Dept Mat Sci & Engn, Pohang, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Surg, Sch Med, Daegu, South Korea; Chung Ang Univ, Coll Med, Dept Anesthesiol & Pain Med, Seoul, South Korea | Oh, Seung Soo/N-6315-2016; Park, Joonhong/AAZ-9885-2020; Kang, Hyun/AAE-7872-2020; Oh, Seung/AAV-2496-2021 | 57224458425; 35226761100; 58298388900; 36126616500 | seungsoo@postech.ac.kr;roman00@naver.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 0.27 | 2025-07-30 | 5 | 6 | ABDOMINIS PLANE BLOCK; POSTOPERATIVE PAIN; LAPAROSCOPIC HYSTERECTOMY; NERVE BLOCKS; INFILTRATION; LIDOCAINE; SURGERY; IMPACT; LENGTH | Animals; Bupivacaine; Disease Models, Animal; Male; Osmosis; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Unilamellar Liposomes; bupivacaine; liposome; animal; disease model; male; osmosis; pathophysiology; postoperative pain; rat; Sprague Dawley rat | English | 2021 | 2021-06-08 | 10.1038/s41598-021-91624-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Overexpression of cathepsin S exacerbates lupus pathogenesis through upregulation TLR7 and IFN-α in transgenic mice | Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs. Recent studies suggest relevance between cysteine protease cathepsin S (CTSS) expression and SLE. To investigate the mechanism of CTSS in SLE, CTSS-overexpressing transgenic (TG) mice were generated, and induced lupus-like symptoms. Eight months later, the TG mice spontaneously developed typical SLE symptoms regardless of the inducement. Furthermore, we observed increased toll-like receptor 7 (TLR7) expression with increased monocyte and neutrophil populations in the TG mice. In conclusion, overexpression of CTSS in mice influences TLR7 expression, autoantibodies and IFN-alpha, which leads to an autoimmune reaction and exacerbates lupus-like symptoms. | Lee, Jinhee; Jang, Soyoung; Choi, Minjee; Kang, Mincheol; Lim, Su-Geun; Kim, SI-Yong; Jang, Soyeon; Ko, Jiwon; Kim, Eungyung; Yi, Junkoo; Choo, Yeonsik; Kim, Myoung Ok; Ryoo, Zae Young | Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea; DGIST, Core Prot Resources Ctr, Daegu, South Korea; Univ Nevada Reno, Sch Med, Dept Physiol & Cell Biol, Reno, NV 89557 USA; Gyeongsangbukdo Livestock Res Inst, Yeongju, South Korea; Kyungpook Natl Univ, Dept Biol, Daegu, South Korea; Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju Si 37224, Gyeongsangbuk D, South Korea | ; Yi, Junkoo/JBR-8507-2023; RYOO, ZAEYOUNG/AAQ-1573-2020 | 57190743495; 57139360300; 56374516800; 57214378634; 56044587400; 57212197751; 57226661947; 57226659428; 57217871658; 56182537200; 26040458100; 8934745900; 16937104900 | ok4325@knu.ac.kr;jaewoong64@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 0.54 | 2025-07-30 | 11 | 12 | I INTERFERON; AUTOANTIBODIES; ERYTHEMATOSUS; MECHANISMS; INDUCTION; PRISTANE; DISEASE; MODELS; CELLS | Animals; Autoantibodies; Cathepsins; Female; Humans; Interferon-alpha; Lupus Erythematosus, Systemic; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Transgenic; Monocytes; Neutrophils; Toll-Like Receptor 7; Up-Regulation; alpha interferon; autoantibody; cathepsin; cathepsin S; membrane protein; Tlr7 protein, mouse; toll like receptor 7; animal; C57BL mouse; female; human; Institute for Cancer Research mouse; metabolism; monocyte; mouse; neutrophil; physiology; systemic lupus erythematosus; transgenic mouse; upregulation | English | 2021 | 2021-08-11 | 10.1038/s41598-021-94855-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | Peritumoral edema in breast cancer at preoperative MRI: an interpretative study with histopathological review toward understanding tumor microenvironment | Peritumoral edema (PE) of breast cancer at T2-weighted MR images is considered a poor prognostic sign and may represent the microenvironment surrounding the tumor; however, its histopathological mechanism remains unclear. The purpose of the study was to identify and describe detailed histopathological characteristics associated with PE at preoperative breast MRI in breast cancer patients. This retrospective study included breast cancer patients who had undergone preoperative MRI and surgery between January 2011 and December 2012. Two radiologists determined the presence of PE in consensus based on the signal intensity surrounding the tumor at T2-weighted images. The following detailed histopathological characteristics were reviewed by two breast pathologists using four-tiered grades; lymphovascular invasion, vessel ectasia, stromal fibrosis, growth pattern, and tumor budding. Tumor necrosis and tumor infiltrating lymphocytes were assessed using a percent scale. Baseline clinicopathological characteristics, including age and histologic grade, were collected. The associations between detailed histopathologic characteristics and PE were examined using multivariable logistic regression with odds ratio (OR) calculation. A total of 136 women (median age, 49 +/- 9 years) were assessed; among them 34 (25.0%) had PE. After adjustment of baseline clinicopathological characteristics that were significantly associated with PE (age, T stage, N stage, histologic grade, and subtype, all Ps<0.05), lymphovascular invasion (P=0.009), vessel ectasia (P=0.021), stromal fibrosis (P=0.024), growth pattern (P=0.036), and tumor necrosis (P<0.001) were also associated with PE. In comparison with patients without PE, patients with PE were more likely to have a higher degree of lymphovascular invasion (OR, 2.9), vessel ectasia (OR, 3.3), stromal fibrosis (OR, 2.5), lesser degree of infiltrative growth pattern (OR, 0.4), and higher portion of tumor necrosis (OR, 1.4). PE of breast cancer at MRI is associated with detailed histopathological characteristics of lymphovascular invasion, vessel ectasia, stromal fibrosis, growth pattern, and tumor necrosis, suggesting a relevance for tumor microenvironment. | Park, Nora Jee-Young; Jeong, Ji Yun; Park, Ji Young; Kim, Hye Jung; Park, Chan Sub; Lee, Jeeyeon; Park, Ho Yong; Jung, Jin Hyang; Kim, Wan Wook; Chae, Yee Soo; Lee, Soo Jung; Kim, Won Hwa | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Pathol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Surg, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Oncol Hematol, Daegu, South Korea | Park, Jin-Young/HDN-0483-2022; PARK, JUN-YOUNG/P-5981-2015 | 57226185359; 57205472984; 57210160197; 57203506201; 57208483662; 37079213100; 56564377200; 57209310173; 26023273400; 57190793908; 57203597252; 36081886500 | greenoaktree9@gmail.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 1.89 | 2025-07-30 | 49 | 44 | EXTRACELLULAR-MATRIX; TARGETING HYPOXIA; IMAGING FEATURES; PROGNOSIS; CARCINOMA; RECOMMENDATIONS | Aged; Biomarkers, Tumor; Breast Neoplasms; Disease Management; Edema; Female; Humans; Magnetic Resonance Imaging; Middle Aged; Neoplasm Grading; Neoplasm Staging; Preoperative Period; Tumor Microenvironment; tumor marker; aged; breast tumor; cancer grading; cancer staging; diagnostic imaging; disease management; edema; female; human; middle aged; nuclear magnetic resonance imaging; pathology; preoperative period; procedures; tumor microenvironment | English | 2021 | 2021-06-21 | 10.1038/s41598-021-92283-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | pH-controlled synthesis of sustainable lauric acid/SiO2 phase change material for scalable thermal energy storage | Lauric acid (LA) has been recommended as economic, eco-friendly, and commercially viable materials to be used as phase change materials (PCMs). Nevertheless, there is lack of optimized parameters to produce microencapsulated PCMs with good performance. In this study, different amounts of LA have been chosen as core materials while tetraethyl orthosilicate (TEOS) as the precursor solution to form silicon dioxide (SiO2) shell. The pH of precursor solution was kept at 2.5 for all composition of microencapsulated LA. The synthesized microencapsulated LA/SiO2 has been characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), X-Ray photoelectron spectroscopy (XPS), Scanning electron microscopy (SEM), and Transmission electron microscopy (TEM). The SEM and TEM confirm the microencapsulation of LA with SiO2. Thermogravimetric analysis (TGA) revealed better thermal stability of microencapsulated LA/SiO2 compared to pure LA. PCM with 50% LA i.e. LAPC-6 exhibited the highest encapsulation efficiency (96.50%) and encapsulation ratio (96.15%) through Differential scanning calorimetry (DSC) as well as good thermal reliability even after 30th cycle of heating and cooling process. | Ishak, Shafiq; Mandal, Soumen; Lee, Han-Seung; Singh, Jitendra Kumar | Hanyang Univ, Dept Architectural Engn, 1271 Sa 3 Dong, Ansan 15588, South Korea; Kyungpook Natl Univ, Intelligent Construct Automat Ctr, 80 Daehak Ro, Daegu 41566, South Korea; Hanyang Univ, Innovat Durable Bldg & Infrastruct Res Ctr, Dept Architectural Engn, 1271 Sa 3 Dong, Ansan 15588, South Korea | ; Mandal, Soumen/AAB-3917-2021; Ishak, Shafiq/ABC-3063-2020; Singh, Jitendra/AAU-6579-2021; Lee, Han-Seung/E-9087-2013; Lee, HanSeung/E-9087-2013 | 57218951467; 57214752240; 57956643400; 57197846307 | ercleehs@hanyang.ac.kr;jk200386@hanyang.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 1.46 | 2025-07-30 | 30 | 35 | MICROENCAPSULATED PARAFFIN; INTERFACIAL POLYMERIZATION; MESOPOROUS SILICA; HEAT-STORAGE; FABRICATION; COMPOSITE; MICROCAPSULES; SHELL; OCTADECANE; PCM | English | 2021 | 2021-07-22 | 10.1038/s41598-021-94571-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Physicochemical properties and structural dynamics of organic-inorganic hybrid [NH3(CH2)3NH3]ZnX4 (X=Cl and Br) crystals | The physical properties of the organic-inorganic hybrid crystals having the formula [NH3(CH2)(3)NH3]ZnX4 (X=Cl, Br) were investigated. The phase transition temperatures (T-C; 268K for Cl and 272K for Br) of the two crystals bearing different halogen atoms in their skeletons were determined through differential scanning calorimetry. The thermodynamic properties of the two crystals were investigated through thermogravimetric analysis. The structural dynamics, particularly the role of the [NH3(CH2)(3)NH3] cation, were probed through H-1 and C-13 magic-angle spinning nuclear magnetic resonance spectroscopy as a function of temperature. The H-1 and C-13 NMR chemical shifts did not show any changes near T-C. In addition, the H-1 spin-lattice relaxation time (T-1 rho) varied with temperature, whereas the C-13 T-1 rho values remained nearly constant at different temperatures. The T-1 rho values of the atoms in [NH3(CH2)(3)NH3]ZnCl4 were higher than those in [NH3(CH2)(3)NH3]ZnBr4. The observed differences in the structural dynamics obtained from the chemical shifts and T-1 rho values of the two compounds can be attributed to the differences in the bond lengths and halogen atoms. These findings can provide important insights or potential applications of these crystals. | Lim, Ae Ran; Ha Kim, Sun; Joo, Yong Lak | Jeonju Univ, Dept Carbon Convergence Engn, Jeonju 55069, South Korea; Jeonju Univ, Dept Sci Educ, Jeonju 55069, South Korea; Korea Basic Sci Inst, Seoul Western Ctr, Seoul 03759, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Cornell Univ, Robert Fredrick Smith Sch Chem & Biomol Engn, Ithaca, NY 14853 USA | Joo, Yong/AAA-8616-2019 | 7202659025; 54386953600; 7102315465 | arlim@jj.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 0.76 | 2025-07-30 | 16 | 16 | MAGNETIC-SUSCEPTIBILITY; PHASE-TRANSITIONS; X-RAY; PEROVSKITE; 1,3-PROPANEDIAMMONIUM; CATIONS; ENERGY; STATE | English | 2021 | 2021-04-16 | 10.1038/s41598-021-87940-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Placental Transfer and Composition of Perfluoroalkyl Substances (PFASs): A Korean Birth Panel of Parent-Infant Triads | Exposure to perfluoroalkyl substances (PFASs) is of public concern due to their persistent exposure and adverse health effects. Placental transfer of PFASs is an important excretion pathway of these chemicals in pregnant women and exposure route in fetuses. We measured PFAS concentrations in maternal, paternal, and umbilical cord serum collected from 62 pregnant Korean women and matched biological fathers of the fetuses. Placental transfer rates (cord to maternal serum ratio) of PFASs were also calculated. Demographics and pregnancy-related factors determining the placental transfer rates were identified using linear regression models. Maternal, paternal, and cord serum showed different PFASs compositions. Among the PFASs, perfluorooctane sulfonate (PFOS) showed the highest concentrations in maternal and paternal serum, while perfluorooctanoic acid (PFOA) showed the highest concentration in cord serum. There was a higher proportion of perfluoroalkyl carboxylic acids (PFCAs) with 9-12 carbon chains than those with 13-14 carbon chains in maternal and paternal serum, but this proportion was in the opposite direction in cord serum. PFOA and perfluorohexane sulfonate (PFHxS) had higher placental transfer rates (means of 0.32 and 0.36, respectively) than PFOS (mean of 0.12), which is in line with the results of previous studies. Gestational age and birth weight were positively associated with placental transfer rate of PFOA, PFHxS, and PFOS, while pre-pregnant BMI and weight were inversely associated with PFOS. This study showed that placental transfer of PFASs differs by compounds and is associated with pregnancy-related factors. Further studies on novel PFASs are warranted for Korean pregnant women. | Kang, Habyeong; Kim, Hee-Sun; Yoon, Yeong Sook; Lee, Jeongsun; Kho, Younglim; Lee, Jisun; Chang, Hye Jin; Cho, Yoon Hee; Kim, Young Ah | Seoul Natl Univ, Sch Publ Hlth, Dept Environm Hlth Sci, Seoul 08826, South Korea; Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA; Dongguk Univ, Ilsan Hosp, Dept Obstet & Gynecol, Goyang Si 10326, South Korea; Inje Univ, Ilsan Paik Hosp, Dept Family Med, Ctr Hlth Promot, Goyang Si 10380, South Korea; Eulji Univ, Sch Human & Environm Serv, Dept Hlth Environm & Safety, Seongnam Si 13135, South Korea; Kyungpook Natl Univ, Sch Med, Kyungpook Natl Univ Hosp, Dept Obstet & Gynecol, Daegu 41944, South Korea; Ajou Univ, Sch Med, Ajou Univ Hosp, Dept Obstet & Gynecol, Suwon 16499, South Korea; Univ Montana, Dept Biomed & Pharmaceut Sci, Missoula, MT 59812 USA; Inje Univ, Ilsan Paik Hosp, Dept Obstet & Gynecol, Goyang Si 10380, South Korea | ; Kang, Habyeong/AAA-7001-2020; Cho, Yoon/AAN-6560-2021 | 57437611000; 57195511578; 8659033200; 57205622281; 36546062200; 57216463710; 56656804100; 55472222600; 57205628180 | habyeonk@umich.edu;smallkong7@gmail.com;ysyoon@paik.ac.kr;dlwjdtjs2121@naver.com;ylkho@eulji.ac.kr;vmariagnes@gmail.com;zzanga-94@ajou.ac.kr;yoonhee.cho@umontana.edu;camanbal@paik.ac.kr; | TOXICS | TOXICS | 2305-6304 | 9 | 7 | SCIE | ENVIRONMENTAL SCIENCES;TOXICOLOGY | 2021 | 4.472 | 25.0 | 2.03 | 2025-07-30 | 30 | 33 | perfluoroalkyl acids; cord blood; placenta; pregnancy; prenatal exposure | POLYFLUOROALKYL SUBSTANCES; PERFLUORINATED COMPOUNDS; SERUM CONCENTRATIONS; PERFLUOROOCTANE SULFONATE; CORD SERA; TRANSPLACENTAL TRANSFER; PREGNANT-WOMEN; FETAL ORGANS; EXPOSURE; HEALTH | Cord blood; Perfluoroalkyl acids; Placenta; Pregnancy; Prenatal exposure | carbon; carboxylic acid derivative; organofluorine derivative; perfluoroalkyl substance; perfluorobutane sulfonate; perfluorodecanoic acid; perfluorododecanoic acid; perfluorohexanesulfonic acid; perfluorohexanoic acid; perfluorononanoic acid; perfluorooctanesulfonic acid; perfluorooctanoic acid; perfluoropentanoic acid; perfluorotetradecanoic acid; perfluorotridecanoic acid; perfluoroundecanoic acid; sulfonic acid derivative; unclassified drug; adult; Article; birth weight; blood level; blood sampling; body mass; body weight; chemical composition; cord serum; father; female; fetus; gestational age; human; male; maternal serum; newborn; placental transfer; pregnancy; pregnant woman; prenatal exposure; South Korean | English | 2021 | 2021-07 | 10.3390/toxics9070168 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Poly[2-(methacryloyloxy)ethyl phosphorylcholine]-Stabilized graphene-iron oxide composites for water splitting | The electrolysis of water is considered as a potentially realistic technology for the massive production of hydrogen. The use of graphene composites in electrocatalytic water splitting has been extensively investigated. Graphene-iron oxide composites were prepared via in situ polymerization of 2-(methacryloyloxy)ethyl phosphorylcholine (MPC) and poly (ethylene glycol) monomethacrylate (PEG) on graphene surface (non-oxidative graphite-HOPG/G) in presence of iron oxide nanoparticles (IONPs) and denoted as G-INSCP. Co-polymers PMPC-co-PEG (CP) and block copolymer PMPC-b-PEG (BCP) were prepared and their structures were thoroughly characterized. These polymers were used to prepare G-INSCP, G-CP, and G-BCP, their stabilities were compared and their morphologies were studied. HOPG, G-CP, and G-INSCP were used in the hydrogen evolution reaction (HER) as effective platinum catalyst alternatives. G-BCP composite was excluded owing to its very low stability. To evaluate the performance of these electrocatalysts in acidic media, linear sweep voltammetry and electrochemical impedance spectroscopy were employed. Results revealed that, compared with HOPG and G-CP, G-INSCP exhibited a significantly improved catalytic activity with respect to HER in an acidic electrolyte. Additionally, at a current density of 10 mA cm(-2), G-INSCP demonstrated a lower overpotential and Tafel slope of 95 mVRHE and 67 mV dec(-1), respectively. These observations were attributed to the synergistic effect between the magnetic IONPs and PMPC polymer along with the increase in the electron transfer rate owing to the conductive graphene in the catalyst. Thus G-INSCP catalyst can be a potential candidate for HER and paving the way for the advancement of new and similar catalysts for other applications. (C) 2021 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved. | Perumal, Suguna; Atchudan, Raji; Cheong, In Woo | Kyungpook Natl Univ, Sch Engn, Dept Appl Chem, Daegu 41566, South Korea; Yeungnam Univ, Sch Chem Engn, Gyongsan 38541, South Korea | RAJI, ATCHUDAN/C-9904-2017; perumal, suguna/N-9075-2017 | 56673798900; 26648054700; 7006733373 | suguna.perumal@gmail.com;inwoo@knu.ac.kr; | INTERNATIONAL JOURNAL OF HYDROGEN ENERGY | INT J HYDROGEN ENERG | 0360-3199 | 1879-3487 | 46 | 18 | SCIE | CHEMISTRY, PHYSICAL;ELECTROCHEMISTRY;ENERGY & FUELS | 2021 | 7.139 | 25.0 | 0.81 | 2025-07-30 | 13 | 15 | PMPC polymer; Iron oxide nanoparticles; Graphene-polymer composite; Water splitting; Hydrogen evolution reaction | HYDROGEN EVOLUTION REACTION; PARTIAL OXIDATION; BLOCK-COPOLYMERS; CARBON NANOTUBE; EFFICIENT; ELECTROCATALYST; PERFORMANCE; STORAGE; DISPERSIONS; GLUCOSE | Graphene-polymer composite; Hydrogen evolution reaction; Iron oxide nanoparticles; PMPC polymer; Water splitting | Block copolymers; Catalyst activity; Electrocatalysts; Electrochemical impedance spectroscopy; Electrolytes; Electron transport properties; Hydrogen evolution reaction; Hydrogen production; Iron oxides; Magnetic nanoparticles; Polyethylene glycols; Polyethylene oxides; Acidic electrolytes; Electrolysis of waters; Electron transfer rates; Graphene composites; In-situ polymerization; Iron oxide nanoparticles (IONPs); Linear sweep voltammetry; Synergistic effect; Graphene | English | 2021 | 2021-03-11 | 10.1016/j.ijhydene.2020.12.156 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Predictive value of pre-arrest albumin level with GO-FAR score in patients with in-hospital cardiac arrest | We investigated whether combining the pre-arrest serum albumin level could improve the performance of the Good Outcome Following Attempted Resuscitation (GO-FAR) score for predicting neurologic outcomes in in-hospital cardiac arrest patients. Adult patients who were admitted to a tertiary care hospital between 2013 and 2017 were assessed. Their pre-arrest serum albumin levels were measured within 24 h before the cardiac arrest. According to albumin levels, the patients were divided into quartiles and were assigned 1, 0, 0, and, -2 points. Patients were allocated to the derivation (n=419) and validation (n=444) cohorts. The proportion of favorable outcome increased in a stepwise manner across increasing quartiles (p for trend <0.018). Area under receiver operating characteristic curve (AUROC) of the albumin-added model was significantly higher than that of the original GO-FAR model (0.848 vs. 0.839; p=0.033). The results were consistent in the validation cohort (AUROC 0.799 vs. 0.791; p=0.034). Net reclassification indices of the albumin-added model were 0.059 (95% confidence interval [CI] -0.037 to 0.094) and 0.072 (95% CI 0.013-0.132) in the derivation and validation cohorts, respectively. An improvement in predictive performance was found by adding the ordinal scale of pre-arrest albumin levels to the original GO-FAR score. | Hong, Seok-In; Kim, Youn-Jung; Cho, Yeon Joo; Huh, Jin Won; Hong, Sang-Bum; Kim, Won Young | Univ Ulsan, Dept Emergency Med, Asan Med Ctr, Coll Med, Seoul 05505, South Korea; Kyungpook Natl Univ, Dept Emergency Med, Sch Med, Daegu 41404, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pulm & Crit Care Med, Seoul 05505, South Korea | Huh, Jin/AAN-5652-2020; Kim, Yong Won/AAA-2134-2022 | 56763081800; 35280110200; 57219251787; 7102258542; 10439962800; 55661654200 | wonpia73@naver.com; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 0.59 | 2025-07-30 | 11 | 12 | SERUM-ALBUMIN; CARDIOPULMONARY-RESUSCITATION; SURVIVAL; VALIDATION | Aged; Albumins; Area Under Curve; Cardiopulmonary Resuscitation; Cohort Studies; Female; Heart Arrest; Hospitals; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Patient Discharge; Predictive Value of Tests; Reproducibility of Results; ROC Curve; Treatment Outcome; albuminoid; aged; area under the curve; blood; cohort analysis; female; heart arrest; hospital; hospital discharge; human; male; metabolism; middle aged; multivariate analysis; predictive value; receiver operating characteristic; reproducibility; resuscitation; statistical model; treatment outcome | English | 2021 | 2021-05-20 | 10.1038/s41598-021-90203-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Proteomic profile and morphological characteristics of skeletal muscle from the fast- and slow-growing yellow perch (Perca flavescens) | The objective of the present study was to compare skeletal muscle proteomic profiles, histochemical characteristics, and expression levels of myogenic regulatory factors (MRFs) between fast- versus slow-growing yellow perch Perca flavescens and identify the proteins/peptides that might play a crucial role in the muscle growth dynamic. Yellow perch were nursed in ponds for 6 weeks from larval stage and cultured in two meter diameter tanks thereafter. The fingerlings were graded to select the top 10% and bottom 10% fish which represented fast- and slow-growing groups (31 yellow perch per each group). Our statistical analyses showed 18 proteins that had different staining intensities between fast- and slow-growing yellow perch. From those proteins 10 showed higher expression in slow-growers, and 8 demonstrated higher expression in fast-growers. Fast-growing yellow perch with a greater body weight was influenced by both the muscle fiber hypertrophy and mosaic hyperplasia compared to slow-growing fish. These hyperplastic and hypertrophic growth in fast-grower were associated with not only metabolic enzymes, including creatine kinase, glycogen phosphorylase, and aldolase, but also myoD and myogenin as MRFs. Overall, the results of the present study contribute to the identification of different expression patterns of gene products in fast- and slow-growing fish associated with their muscle growth. | Kwasek, Karolina; Choi, Young Min; Wang, Hanping; Lee, Kichoon; Reddish, John Mark; Wick, Macdonald | Southern Illinois Univ, Sch Biol Sci, Ctr Fisheries Aquaculture & Aquat Sci, Carbondale, IL USA; Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju, South Korea; Ohio State Univ South Ctr, Ohio Ctr Aquaculture Res & Dev, Piketon, OH USA; Ohio State Univ, Dept Anim Sci, Columbus, OH 43210 USA; Ohio State Univ, Sch Vet Med, Columbus, OH 43210 USA | ; Choi, Young/J-6027-2014; Lee, Kichoon/G-2234-2012 | 24758971300; 57226673843; 57223721557; 14123395400; 6602237927; 7202397110 | wick.13@osu.edu; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 0.38 | 2025-07-30 | 9 | 9 | MYOGENIC REGULATORY FACTORS; QUANTITATIVE EXPRESSION; GROWTH; PROTEINS; MYOD; HYPERPLASIA; PATTERNS; TROUT; GENE; MASS | Animals; Creatine Kinase; Fructose-Bisphosphate Aldolase; Gene Expression; Glycogen Phosphorylase; Muscle, Skeletal; Myogenic Regulatory Factors; Perches; Proteomics; creatine kinase; fructose bisphosphate aldolase; glycogen phosphorylase; myogenic factor; anatomy and histology; animal; gene expression; genetics; growth, development and aging; metabolism; perch; proteomics; skeletal muscle | English | 2021 | 2021-08-11 | 10.1038/s41598-021-95817-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Quantitative gait analysis of idiopathic normal pressure hydrocephalus using deep learning algorithms on monocular videos | A vision-based gait analysis method using monocular videos was proposed to estimate temporo-spatial gait parameters by leveraging deep learning algorithms. This study aimed to validate vision-based gait analysis using GAITRite as the reference system and analyze relationships between Frontal Assessment Battery (FAB) scores and gait variability measured by vision-based gait analysis in idiopathic normal pressure hydrocephalus (INPH) patients. Gait data from 46 patients were simultaneously collected from the vision-based system utilizing deep learning algorithms and the GAITRite system. There was a strong correlation in 11 gait parameters between our vision-based gait analysis method and the GAITRite gait analysis system. Our results also demonstrated excellent agreement between the two measurement systems for all parameters except stride time variability after the cerebrospinal fluid tap test. Our data showed that stride time and stride length variability measured by the vision-based gait analysis system were correlated with FAB scores. Vision-based gait analysis utilizing deep learning algorithms can provide comparable data to GAITRite when assessing gait dysfunction in INPH. Frontal lobe functions may be associated with gait variability measurements using vision-based gait analysis for INPH patients. | Jeong, Sungmoon; Yu, Hosang; Park, Jaechan; Kang, Kyunghun | Kyungpook Natl Univ, Sch Med, Dept Med Informat, Daegu, South Korea; Kyungpook Natl Univ Hosp, Res Ctr Artificial Intelligence Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu, South Korea | 23100090400; 57205199961; 44661451000; 55365592200 | jparkmd@hotmail.com;kangkh@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 0.49 | 2025-07-30 | 9 | 11 | CEREBRAL-BLOOD-FLOW; FRONTAL ASSESSMENT BATTERY; OLDER-ADULTS; TAP TEST; RELIABILITY; VALIDITY; SPECT; DISTURBANCE; PARAMETERS; VARIABILITY | Aged; Aged, 80 and over; Algorithms; Deep Learning; Female; Gait Analysis; Humans; Hydrocephalus, Normal Pressure; Male; Prospective Studies; Republic of Korea; Vision, Monocular; aged; algorithm; female; gait; human; male; monocular vision; normotensive hydrocephalus; pathophysiology; prospective study; South Korea; very elderly | English | 2021 | 2021-06-11 | 10.1038/s41598-021-90524-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Radioiodine labeling and in vivo trafficking of extracellular vesicles | Biodistribution and role of extracellular vesicles (EVs) are still largely unknown. Reliable tracking methods for EVs are needed. In this study, nuclear imaging using radioiodine were developed and applied for tracking EVs derived from cell lines. EVs were obtained from supernatant of thyroid cancer cell (Cal62) and natural killer cells (NK92-MI) using sequential ultracentrifuges. Sulfosuccinimidyl-3-(4-hydroxypheynyl) propionate were labeled to membrane of Cal62 and NK92-MI cell derived EVs, then the EVs were labeled with radioiodine (I-131 and I-125) using pre-coated iodination tubes (RI-EVs). In vivo gamma camera images were obtained after intravenous injection of the RI-EVs, and ex vivo biodistribution study was also performed. EVs were labeled with radioiodine and radiochemical purity of the RI-EV was more than 98%. Results of nanoparticle tracking analysis and electron microscopy showed that there was no significant difference in EVs before and after the radioiodine labeling. After intravenous injection of RI-EVs to mice, gamma camera imaging well visualized the real-time biodistribution of the RI-EVs. RI-EVs were mainly visualized at liver, spleen, and lung. Nuclear imaging system of EVs derived from thyroid cancer and NK cells using radioiodine labeling of the EVs was established. Thus, this system might be helpful for in vivo tracking of EVs. | Hong, Chae Moon; Gangadaran, Prakash; Oh, Ji Min; Rajendran, Ramya Lakshmi; Gopal, Arunnehru; Zhu, Liya; Ahn, Byeong-Cheol | Kyungpook Natl Univ, Sch Med, Dept Nucl Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu, South Korea | Rajendran, Ramya/AAV-6338-2021; Gangadaran, Prakash/AAV-3102-2021 | 37050876700; 54393130400; 57190370462; 57195318729; 57203278478; 57190870383; 7202791511 | abc2000@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 0.81 | 2025-07-30 | 16 | 16 | MESENCHYMAL STEM-CELLS; BIODISTRIBUTION; NANOPARTICLES | Animals; Cell Line, Tumor; Extracellular Vesicles; Female; Humans; Injections, Intravenous; Iodine Radioisotopes; Killer Cells, Natural; Liver; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron; Nanoparticles; Radionuclide Imaging; Spleen; Staining and Labeling; Thyroid Neoplasms; Tissue Distribution; Iodine-125; Iodine-131; nanoparticle; radioactive iodine; animal; Bagg albino mouse; electron microscopy; exosome; female; human; intravenous drug administration; liver; metabolism; mouse; natural killer cell; nude mouse; pathology; procedures; scintiscanning; spleen; staining; thyroid tumor; tissue distribution; tumor cell line | English | 2021 | 2021-03-03 | 10.1038/s41598-021-84636-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Reappraisal of bone scintigraphy as a new tool for the evaluation of disease activity in patients with rheumatoid arthritis | We aimed to compare the reliability of bone scintigraphy (BS) and fluorine-18-fluorodeoxyglucose (F-18-FDG) positron emission tomography (PET)-derived parameters in the detection of active arthritis in 28-joint areas and evaluate the reliability of joint counts between BS and clinical assessment in patients with rheumatoid arthritis (RA). We enrolled 106 patients (67 in the development group and 39 in the validation groups) with active RA who underwent BS, F-18-FDG PET/computed tomography (CT), and clinical evaluation of disease activity. We compared the results of BS-derived joint assessment with those of PET-derived and clinical joint assessments. Subsequently we developed a disease activity score (DAS) using BS-positive joints and validated it in an independent group. The number of BS-positive joints in 28-joint areas significantly correlated with the swollen /tender joint counts (SJC/TJC) and PET-derived joint counts. A BS uptake score of 2 (strong positive) was significantly more sensitive compared with a BS uptake score of 1 (weak positive) in detecting a PET-positive joint among the 28-joints. After conducting multivariate analyses including erythrocyte sediment rate (ESR) and patient global assessment (PGA) in addition to BS-derived parameters, BS/DAS was obtained as follows: 0.056 x number of BS-positive joints in 28 joints + 0.012 x ESR + 0.030 x PGA. A significant correlation between BS/DAS and DAS28-ESR was confirmed in the validation group. Strong positive uptake of BS is sensitive and reproducible for the detection of active joints, and can complement the clinical assessment of disease activity in RA. | Lee, Sang Jin; Hong, Chae Moon; Cho, Il; Ahn, Byeong-Cheol; Eun, Jung Su; Kim, Na Ri; Kang, Jong Whan; Kang, Young Mo | Kyungpook Natl Univ, Dept Internal Med Rheumatol, Sch Med, Kyungpook Natl Univ Hosp, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Korea, South Korea | Li, Shaofu/O-2241-2019 | 57192516055; 37050876700; 57325415700; 7202791511; 57271176000; 58113116000; 59068856600; 26221798000 | ymkang@knu.ac.kr; | SCIENTIFIC REPORTS | SCI REP-UK | 2045-2322 | 11 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 4.997 | 25.0 | 0.11 | 2025-07-30 | 3 | 3 | JOINT COUNTS; GREY-SCALE; ULTRASONOGRAPHY; RELIABILITY; AGREEMENT; DIAGNOSIS; FUTURE | Aged; Arthritis, Rheumatoid; Bone and Bones; Female; Humans; Joints; Male; Positron Emission Tomography Computed Tomography; Radionuclide Imaging; Reproducibility of Results; aged; bone; diagnostic imaging; female; human; joint; male; pathology; positron emission tomography-computed tomography; procedures; reproducibility; rheumatoid arthritis; scintiscanning | English | 2021 | 2021-11-08 | 10.1038/s41598-021-01104-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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